Journal of Clinical Medicine Article Dynamic Hyperglycemic Patterns Predict Adverse Outcomes in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy 1,2, , 2,3, 4 2,5 Giovanni Merlino * y , Carmelo Smeralda y , Massimo Sponza , Gian Luigi Gigli , Simone Lorenzut 1, Alessandro Marini 2,3 , Andrea Surcinelli 2,3, Sara Pez 2,3, Alessandro Vit 4, Vladimir Gavrilovic 4 and Mariarosaria Valente 2,3 1 Stroke Unit, Department of Neuroscience, Udine University Hospital, 33100 Udine, Italy;
[email protected] 2 Clinical Neurology, Udine University Hospital, 33100 Udine, Italy;
[email protected] (C.S.);
[email protected] (G.L.G.);
[email protected] (A.M.);
[email protected] (A.S.);
[email protected] (S.P.);
[email protected] (M.V.) 3 DAME, University of Udine, 33100 Udine, Italy 4 Division of Vascular and Interventional Radiology, Udine University Hospital, 33100 Udine, Italy;
[email protected] (M.S.);
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[email protected] (V.G.) 5 DMIF, University of Udine, 33100 Udine, Italy * Correspondence:
[email protected]; Tel.: +39-043-255-2720 These authors contributed equally to this study. y Received: 5 May 2020; Accepted: 18 June 2020; Published: 20 June 2020 Abstract: Background: Admission hyperglycemia impairs outcome in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT). Since hyperglycemia in AIS represents a dynamic condition, we tested whether the dynamic patterns of hyperglycemia, defined as blood glucose levels > 140 mg/dl, affect outcomes in these patients. Methods: We retrospectively analyzed data of 200 consecutive patients with prospective follow-up.