Muscle Hypertrophy and Muscle Strength: Dependent Or Independent Variables? a Provocative Review Carlo Reggiani (1,2), Stefano Schiaffino (3)
Muscle hypertrophy and muscle strength Eur J Transl Myol 2020; 30 (3): 9311. doi: 10.4081/ejtm.2020.9311 Muscle hypertrophy and muscle strength: dependent or independent variables? A provocative review Carlo Reggiani (1,2), Stefano Schiaffino (3) (1) Department of Biomedical Sciences of the University of Padova, Padova, Italy; (2) Science and Research Centre Koper, Institute for Kinesiology Research, Koper, Slovenia; (3) VIMM - Venetian Institute of Molecular Medicine, Padova, Italy This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (CC BY-NC 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Abstract The question whether the muscle hypertrophy induced by resistance training, hormone administration or genetic manipulation is accompanied by a proportional increase in muscle strength is still open. This review summarizes and analyses data obtained in human and rodent muscles in studies that have monitored in parallel changes in muscle size and changes in muscle force, measured in isometric contractions in vivo, in isolated muscles ex vivo (in rodents) and in single muscle fibers. Although a general positive relation exists among the two variables, a number of studies show a clear dissociation with increase of muscle size with no change or even decrease in strength and, vice versa, increase in strength without increase in size. The possible mechanisms of such dissociation, which involves neural motor control and/or cellular and molecular adaptations of muscle fibers, are briefly discussed. Key Words: skeletal muscle, hypertrophy, resistance training, contractile force. Eur J Transl Myol 2020; 30 (3): 9311.
[Show full text]