RETRACING and HEALING REACTIONS by Dr
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Pathogenesis of Relapsing Fever
Curr. Issues Mol. Biol. 42: 519-550. caister.com/cimb Pathogenesis of Relapsing Fever Job Lopez1, Joppe W. Hovius2 and Sven Bergström3 1Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston TX, USA 2Center for Experimental and Molecular Medicine, Amsterdam Medical centers, location Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands 3Department of Molecular Biology, Umeå Center for Microbial Research, Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden *Corresponding author: [email protected] DOI: https://doi.org/10.21775/cimb.042.519 Abstract outbreaks of RF. One of the best recorded Relapsing fever (RF) is caused by several species of descriptions of RF came from the physician John Borrelia; all, except two species, are transmitted to Rutty, who kept a detailed diary during his time in humans by soft (argasid) ticks. The species B. Dublin, where he described the weather and illnesses recurrentis is transmitted from one human to another in the area during the mid-1700’s (Rutty, 1770). by the body louse, while B. miyamotoi is vectored by Interestingly, the fatality rate was very low and most hard-bodied ixodid tick species. RF Borrelia have of the affected people did recover after two or three several pathogenic features that facilitate invasion relapses. and dissemination in the infected host. In this article we discuss the dynamics of vector acquisition and RF symptoms also were described in detail by field subsequent transmission of RF Borrelia to their medics during the 1788 Swedish-Russian war. The vertebrate hosts. We also review taxonomic Swedish navy conquered the Russian 74-cannon challenges for RF Borrelia as new species have been battleship Vladimir and its 783 men crew at a battle in isolated throughout the globe. -
Epidemiology of Leptospirosis in New Caledonia and Futuna
Epidemiology of leptospirosis in New Caledonia and Futuna : symptomatic infections in children, symptomatic reinfections and incidence of Jarisch-Herxheimer reactions Gilles Guerrier To cite this version: Gilles Guerrier. Epidemiology of leptospirosis in New Caledonia and Futuna : symptomatic infec- tions in children, symptomatic reinfections and incidence of Jarisch-Herxheimer reactions. Infectious diseases. Université Pierre et Marie Curie - Paris VI, 2017. English. NNT : 2017PA066012. tel- 01676711 HAL Id: tel-01676711 https://tel.archives-ouvertes.fr/tel-01676711 Submitted on 6 Jan 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Dossier de Validation des Acquis de l’Expérience En vue de l’obtention d’un doctorat Spécialité : Épidémiologie École Doctorale Pierre Louis de Santé Publique : Épidémiologie et Sciences de l'Information Biomédicale (ED 393) de l’UPMC Gilles Guerrier - 4 janvier 2017 1 Abbreviations AP-HP : Assistance Publique Hôpitaux de Paris CHT: Centre hospitalier territorial CT: Cranial traumatism CRISPR: clustered regulatory -
Pooja Kadam, Ki-Tae Mok, Cynthia Carlyn from the Department of Medicine, Albany VA Medical Center, 113 Holland Avenue, Albany, New York 12208
JOURNAL OF CASE REPORTS 2013;3(2):362-365 Jarisch – Herxheimer Reaction in a Patient with Disseminated Lyme Disease Pooja Kadam, Ki-Tae Mok, Cynthia Carlyn From the Department of Medicine, Albany VA Medical Center, 113 Holland Avenue, Albany, New York 12208. Abstract: A 61-year-old man presented with a 2 week history of intermittent fever, recurrent headaches, arthralgia’s and a non-pruritic erythematous macular rash on his right lower abdomen. The patient underwent an uncomplicated lumbar puncture and was commenced on antibiotics for suspected early disseminated Lyme disease. Few hours after the first antibiotic dose he had abrupt onset of high fevers, chills, hypotension and tachycardia requiring fluid resuscitation and antipyretics. Jarisch-Herxheimer reaction (JHR) is a transient shock-like syndrome that typically follows initiation of antibiotics and is classically associated with penicillin treatment of syphilis. We discuss a patient of disseminated Lyme disease who developed JHR after commencing antibiotic therapy. Key words: Lyme Disease, Spirochaetales, Syphilis, Arthralgia, Exanthema, Hypotension. Introduction Jarisch-Herxheimer reaction (JHR) is associated rash on his right lower abdomen. He describes with diseases caused by sphirochetes including headaches with increasing severity and frequency. syphilis, Lyme disease, tick-borne relapsing fever He also reports having diaphoresis during the and babesiosis. We present a case of patient who nighttime that makes him feel marginally better. He developed JHR after commencing antibiotic therapy recalls removing ticks off his head for the last few for disseminated Lyme disease. We trust this case years including a few days prior presentation and will be useful to physicians and students evaluating stated that it was not unusual for them to appear and managing patients with Lyme disease. -
Neurosyphilis in the Netherlands Then and Now
NEUROSYPHILIS IN THE NETHERLANDS NEUROSYPHILIS NEUROSYPHILIS UITNODIGING Ik nodig u van harte uit voor het bijwonen van de openbare IN THE NETHERLANDS verdediging van mijn proefschrift NEUROSYPHILIS THEN AND NOW IN THE NETHERLANDS THEN AND NOW op donderdag 31 oktober 2019 THEN AND NOW Ingrid Marianne Daey Ouwens om 11.30 uur precies in de Senaatszaal (A-gebouw) van het complex Woudestein Erasmus Universiteit Burgemeester Oudlaan 50 3062 PA Rotterdam Aansluitend aan de ceremonie is er een receptie voor alle aanwezigen. Ik kijk er naar uit om u op 31 oktober te zien! Ingrid Marianne Daey Ouwens Homeruslaan 51 3707 GP Zeist Paranymfen Elisabeth Lens Ingrid Marianne Daey Ouwens Ingrid Marianne Daey [email protected] Aernoud Fiolet [email protected] NB: Mocht u niet aanwezig kunnen zijn, wilt u dan zo vriendelijk zijn dat via bovenstaand emailadres te laten weten? NEUROSYPHILIS IN THE NETHERLANDS THEN AND NOW Ingrid Marianne Daey Ouwens Neurosyfilis in Nederland: toen en nu NEUROSYPHILIS IN THE NETHERLANDS: THEN AND NOW Proefschrift ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof.dr. R.C.M.E. Engels en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op 31 oktober 2019 om 11:30u door Ingrid Marianne Daey Ouwens geboren te ‘s Gravenhage ISBN: 978-94-6332-558-5 The research described in this thesis was performed at the Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands. The author gratefully acknowledges financial support for the printing of this thesis by the Research department of Stichting Epilepsie Instellingen Nederland (SEIN) and the Erasmus University Rotterdam. -
Applying Common Sense & Lessons Learned in Lyme Borreliosis Complex
Applying common sense & lessons learned in Lyme Borreliosis Complex JOSEPH G. JEMSEK MD, FACP IM/ID-BC, HIV-AIDS/Lyme Specialist Jemsek Specialty Clinic Washington, D.C. MAY 15, 2016 LIFTING THE VEIL: ACADEMY OF NUTRITIONAL MEDICINE, UK Disclosure Dr. Joseph G. Jemsek and the Jemsek Specialty Clinic have no financial relationship or any commercial interests related to the content of this presentation 2 Jemsek Specialty Clinic 23 Years background in HIV/ AIDS treatment through 2006 Dr. Jemsek diagnosed the first cases of AIDS in North Carolina in 1983 Fully dedicated treatment of tick-borne illness since 2001 Destination practice Patients from every state in America & over a dozen countries Over 10,000 Lyme Borreliosis Complex (LBC) patients seen by the practice & currently more than 3000 active patients 36 employees including 6 medical providers and researcher 3 Credits Uche R. Omabu, MD, MBA, JSC Researcher William Sweeney, VP Business Development, Danconia Media Kimberly B. Fogarty, PA-C, JSC Tara R. Fox, CPNP, JSC Rachel Markey, PA-C, JSC Lauren Shannon, FNP, JSC Kelly Lennon, AGNP-BC, JSC Leigh Kincer, special assistant, JSC Mark Pellin, journalist and media consultant John Allen, media consultant PJ Langhoff, Noted Author and Researcher 4 Thank you for this opportunity to address you today “Everything I have learned… truly learned... in the practice of medicine, I have learned from my patients.” Joseph G. Jemsek MD, FACP 5 Above All, A Physician A life and journey in the profession of Medicine is a gift from God. Compassion for his fellow man and a lifetime dedicated to learning Medicine are the measure for the physician of His gift requited.