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Assessing Prognosis in Uveal Melanoma Uveal in Prognosis Assessing cancercontroljournal.org Vol. 23, No. 2, April 2016 H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, AN NCI COMPREHENSIVE CANCER CENTER Assessing Prognosis in Uveal Melanoma Zélia M. Corrêa, MD, PhD Therapeutic Options for Retinoblastoma Pia R. Mendoza, MD, and Hans E. Grossniklaus, MD Primary Vitreoretinal Lymphoma: Management of Isolated Ocular Disease Matthew T. Witmer, MD Management of Primary Acquired Melanosis, Nevus, and Conjunctival Melanoma Andrew Kao, MD, Armin Afshar, MD, Michele Bloomer, MD, et al Sebaceous Carcinoma of the Eyelid Carlos Prieto-Granada, MD, and Paul Rodriguez-Waitkus, MD, PhD Role of Vismodegib in the Management of Advanced Periocular Basal Cell Carcinoma Kyle F. Cox, MD, and Curtis E. Margo, MD Extranodal Marginal Zone B-cell Lymphoma of the Ocular Adnexa Jean Guffey Johnson, MD, Lauren A. Terpak, MS, Curtis E. Margo, MD, et al Ophthalmic Complications Related to Chemotherapy in Medically Complex Patients Lynn E. Harman, MD Cancer Control is included in Index Medicus/MEDLINE Permit No. 4390 No. Permit Jacksonville, FL FL Jacksonville, Tampa FL 33612-9416 FL Tampa P A I D I A P 12902 Magnolia Drive Magnolia 12902 U.S. POSTAGE U.S. & RESEARCH INSTITUTE INC INSTITUTE RESEARCH & NON-PROFIT ORG NON-PROFIT CENTER CANCER MOFFITT LEE H Editorial Board Members Editor: Richard D. Kim, MD Production Team: Associate Member Veronica Nemeth Lodovico Balducci, MD Gastrointestinal Oncology Senior Member Editorial Coordinator Bela Kis, MD, PhD Program Leader, Senior Adult Oncology Program Sherri Damlo Assistant Member Moffitt Cancer Center Medical Copy Editor Diagnostic Radiology Diane McEnaney Rami Komrokji, MD Deputy Editor: Graphic Design Consultant Associate Member Julio M. Pow-Sang, MD Malignant Hematology Senior Member Associate Editor of Conor C. Lynch, PhD Chair, Department of Genitourinary Oncology Assistant Member Educational Projects Director of Moffitt Robotics Program Tumor Biology John M. York, PharmD Moffitt Cancer Center Akita Biomedical Consulting Kristen J. Otto, MD 1111 Bailey Drive Associate Member Editor Emeritus: Paso Robles, CA 93446 Head and Neck and Phone: 805-238-2485 John Horton, MB, ChB Endocrine Oncology Professor Emeritus of Medicine & Oncology Fax: 949-203-6115 Michael A. Poch, MD E-mail: [email protected] Assistant Member Guest Editor: Genitourinary Oncology For Consumer and Curtis E. Margo, MD Jeffery S. Russell, MD, PhD Professor General Advertising Assistant Member Information: Departments of Pathology and Cell Biology Endocrine Tumor Oncology and Ophthalmology Veronica Nemeth Elizabeth M. Sagatys, MD Morsani College of Medicine Editorial Coordinator Assistant Member University of South Florida Cancer Control: Pathology - Clinical Journal of the Moffitt Cancer Center Moffitt Cancer Center Saïd M. Sebti, PhD 12902 Magnolia Drive – MBC-JRNL Journal Advisory Committee: Senior Member Tampa, FL 33612 Drug Discovery Phone: 813-745-1348 Daniel A. Anaya, MD Bijal D. Shah, MD Fax: 813-449-8680 Associate Member Assistant Member E-mail: [email protected] Gastrointestinal Oncology Malignant Hematology Aliyah Baluch, MD Lubomir Sokol, MD, PhD Assistant Member Senior Member Infectious Diseases Hematology/Oncology Dung-Tsa Chen, PhD Hatem H. Soliman, MD Associate Member Assistant Member Biostatistics Breast Oncology Hey Sook Chon, MD Jonathan R. Strosberg, MD Assistant Member Assistant Member Gynecological Oncology Gastrointestinal Oncology Jasreman Dhillon, MD Jennifer Swank, PharmD Assistant Member Clinical Pharmacist - Pathology - Anatomic Medical Oncology/Internal Medicine Jennifer S. Drukteinis, MD Sarah W. Thirlwell, MSc, MSc(A), RN Associate Member Nurse Director Diagnostic Radiology Supportive Care Medicine Program Cancer Control is a member of Clement K. Gwede, PhD Eric M. Toloza, MD, PhD the Medscape Publishers’ Circle®, Associate Member Assistant Member an alliance of leading medical Health Outcomes and Behavior Thoracic Oncology publishers whose content is Sarah E. Hoffe, MD Nam D. Tran, MD featured on Medscape Associate Member Assistant Member (www.medscape.com). Radiation Oncology Neuro-Oncology John V. Kiluk, MD Jonathan S. Zager, MD Most issues and supplements of Associate Member Senior Member Cancer Control are available at Breast Oncology Cutaneous Oncology cancercontroljournal.org CANCER CONTROL: JOURNAL OF THE MOFFITT CANCER CENTER (ISSN 1073-2748) is published by H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612. Telephone: 813-745-1348. Fax: 813-449-8680. E-mail: [email protected]. Internet address: cancercontroljournal.org. Cancer Control is included in Index Medicus ®/MEDLINE® and EMBASE®/ Excerpta Medica, Thomson Reuters Science Citation Index Expanded (SciSearch®) and Journal Citation Reports/Science Edition. Copyright 2016 by H. Lee Moffitt Cancer Center & Research Institute. All rights reserved. Cancer Control: Journal of the Moffitt Cancer Center is a peer-reviewed journal that is published to enhance the knowledge needed by professionals in oncology to help them minimize the impact of human malignancy. Each issue emphasizes a specific theme relating to the detection or management of cancer. The objectives of Cancer Control are to define the current state of cancer care, to integrate recently generated information with historical practice patterns, and to enlighten readers through critical reviews, commentaries, and analyses of recent research studies. DISCLAIMER: All articles published in this journal, including editorials and letters, represent the opinions of the author(s) and do not necessarily reflect the opinions of the editorial board, the H. Lee Moffitt Cancer Center & Research Institute, Inc, or the institutions with which the authors are affiliated unless clearly specified. The reader is advised to independently verify the effective- ness of all methods of treatment and the accuracy of all drug names, dosages, and schedules. Dosages and methods of administration of pharmaceutical products may not be those listed in the package insert and solely reflect the experience of the author(s) and/or clinical investigator(s). April 2016, Vol. 23, No. 2 Cancer Control 87 Table of Contents Editorial Are Ocular and Ocular Adnexal Cancers Overdiagnosed? Historical Perspectives on Diagnosis 90 Curtis E. Margo, MD Articles Assessing Prognosis in Uveal Melanoma 93 Zélia M. Corrêa, MD, PhD Therapeutic Options for Retinoblastoma 99 Pia R. Mendoza, MD, and Hans E. Grossniklaus, MD Primary Vitreoretinal Lymphoma: Management of Isolated Ocular Disease 110 Matthew T. Witmer, MD Management of Primary Acquired Melanosis, Nevus, and 117 Conjunctival Melanoma Andrew Kao, MD, Armin Afshar, MD, Michele Bloomer, MD, and Bertil Damato, MD, PhD Sebaceous Carcinoma of the Eyelid 126 Carlos Prieto-Granada, MD, and Paul Rodriguez-Waitkus, MD, PhD Role of Vismodegib in the Management of Advanced Periocular 133 Basal Cell Carcinoma Kyle F. Cox, MD, and Curtis E. Margo, MD Extranodal Marginal Zone B-cell Lymphoma of the Ocular Adnexa 140 Jean Guffey Johnson, MD, Lauren A. Terpak, MS, Curtis E. Margo, MD, and Reza Setoodeh, MD 88 Cancer Control April 2016, Vol. 23, No. 2 Table of Contents Articles, continued Ophthalmic Complications Related to Chemotherapy in Medically 150 Complex Patients Lynn E. Harman, MD Departments Disparities Report: Disparities Among Minority Women With Breast Cancer Living in 157 Impoverished Areas of California Sundus Haji-Jama, Kevin M. Gorey, PhD, Isaac N. Luginaah, PhD, Guangyong Zou, PhD, Caroline Hamm, MD, and Eric J. Holowaty, MD Infectious Disease Report: Bordetella pertussis Infection in Patients With Cancer 163 Abraham Yacoub, MD, Sowmya Nanjappa, MD, Tyler Janz, and John N. Greene, MD Pharmacy Report: Megestrol Acetate-Induced Adrenal Insufficiency 167 Sowmya Nanjappa, MD, Christy Thai, PharmD, Sweta Shah, MD, and Matthew Snyder, PharmD Pathology Report: Presacral Noncommunicating Enteric Duplication Cyst 170 Shabnam Seydafkan, MD, David Shibata, MD, Julian Sanchez, MD, Nam D. Tran, MD, Marino Leon, MD, and Domenico Coppola, MD Symposium Report: Second Annual Moffitt Anatomic Pathology Symposium 175 Ten Best Readings Relating to Ocular Oncology 187 About the art in this issue: Lynn E. Harman, MD, is an ophthalmologist at the University of South Florida Morsani College of Medicine and the James A. Haley Veterans Affairs Hospital in Tampa, Florida. She practices general ophthalmology and specializes in the diagnosis and treatment of glaucoma. Dr Harman is an amateur photographer who enjoys her hobby when traveling. For the works included in this issue, she used a high-dynamic- range imaging technique which expands the breadth of color and luminosity that is typically captured on a single digital image. Cover: Bernese Alps Articles: Virgin River Gorge Themes at the Shard Manhattan Chicago River Half Dome From Glacier Point Hohenschwangau Castle Los Angeles Point Reyes Beach North April 2016, Vol. 23, No. 2 Cancer Control 89 Editorial Are Ocular and Ocular Adnexal Cancers Overdiagnosed? Historical Perspectives on Diagnosis Applying the term overdiagnosis to cancer reflects a of epidemiological sleuthing and certainly not in the conceptual shift in thinking about cancer as a neoplas- context of screening programs. Claims of overdiagno- tic proliferation based on histopathological criteria to sis were raised because there was a sense of incongrui- a disease that, if left untreated, becomes symptomatic ty between the lesions observed under the microscope and results in morbidity or death.1-3
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