UP-regulated genes
Normal to Latent Infection Normal to Active TB Latent Infection to Active TB
Level 0
AFF4
EAF1
ELP4 LEO1 AFF1 ELL2 ELP3 SNRNP40 ZNF259 WNT11 RYK PAF1SUPT4H1 Level 0 WNT10A CDC5L RTF1 ELLCCNK LSM10 WNT9A WNT16 TXNL4A Level 0 GNG4 COBRA1 PRPF3 KREMEN1 WNT5B WNT7B CDC73 SUPT16H ELL3ELP2GTF2FLSM2 4 GNG13 BRAF RDBP NHP2L1 APCWNT9B GNB3 MLLT3 CTR9 SNRPBZMAT5BUD31 GEMIN8 PARD6A SUPT6HIKBKAP SSRP1 CPPED1 DKK2 WNT1GNAT2GNG3GNGT2 MLLTCDK71 SF3B1 POLR2F USP3CDC49 0 RBM22 DVL1 LSM7 SNRPFLSM6 WNT10BWNT8B GNB1 WDR61 WNT7AFZD5 MDM4AXIN1 CCNT1 SNRPE LSM2 GEMIN6 C1QC RPA1 SUPT5H SNRPN PRPF4 WNT6 CHEK2 PLRG1 GNG7 ARAF ESRRA CCNT2 SNRPB2 XAB2SNRNP200SNRPA1 GNB4 SNW1 SNRNP70 WNT8A RAPGEF1 POLR2B CRNKLSNRPD11 APOL1 SOST FZD1 WNT2FZDBCAR14 B ATM CDK9 POLR2SNRPAE POLR2H SNRPD2 FGD2 LRP5 DOCK1WNT3A MAPK10 CCNH POLR2APOLR2G OXSM C1R WNT3 GNAO1 KAT2B TCEA2 GOSR2 YKT6 MSRA DPM2 ROR1 DVL3 CTNNB1PTEN CDC42 SF3B3SNRPD3 GEMIN5 GEMIN7 MS4A6AC1QA NSF WNT4 PRKDC CHEK1 PCNA POLR2STRAPCPOLR2I SMN2SF3A3LSM5 C1S RCAN1 SNAP25 AGPAT6 ASRGL1 WNT2 SART1 SF3A2 SIGLEC1 CYB5R3 ST20−MTHFS DPM3 DKK4 DKK1GNG5 PYCARD GEMIN2 SLAMF7 VTI1B NFATC3GSK3B ESR1 CDK2HDAC3 DDX23 SNRPNAA3C 8 STX10 STX5 SCFD1 CALML4 TARS2 DPAGT1 LRP6 FZD9 TLN1 MDM2 PRPFEFTUD28 PRPF6 CFI CFH RAC1 PAK1MAPK8 RB1 JUNDNLRP1AR SNRPG SEC22C NAPG HLCS TRAF3PARD3 HIF1A LSM3 C1QB STX3 FPGS VAMP4 DVL2 TEERBB2K RAF1 BIRC2 PRPF31 GEMIN4 ALG5 CLEC12A USE1 FZD2 GDNF MAP3K7CREB1JUN MED13 PRPF19 BET1L C1RLCYB5R2 ATP11A PRKCI WNT5APXN FYNMAPK14AKT1 SIN3ACDKN1A MED23 RNASE6 OTC CYB5RL FARSB PAK2 ITGB3 HRAS TP53 PPARACREBBP IKBKG DDX20 FGL2 SKAP2 RAB3D IARS2 GNG2 CITED2 NR1H4 EP300 FDX1 MTRR GCSH OXNAD1 BTRC PIK3CA NCOR2 MED4 MNDA VPS53 TARSL2 FAM172A ARRB2CRK EGFR HELZ2 SRGAP2 DPYS CRMP1FTCD CYB5A VPS54 NCOA3 LY96 ACAA1 PDSS1 MTHFD2L AMY1A GOSR1 SOS1 RET BAX TICAM1SRC MYC RELMEDA 1 RXRARARA SMN1 FCRL2 ACAA2 SNX15 ENSG00000259753 ROR2 NCOR1 SUCLG1 MTR MAPK9IL2 BAK1CDKN2A NCOA6 CCL8 MTHFD1 MDH2 ACO1 PFKM ALG6 THBS1 BCL2 C1orf162 ACAT2 SDHD TPI1 RPS6KA4 TALDO1 STX6 YES1 LCKGZMA NCOA1TLR1 MAPKAPK2BIRC3 CLEC4SELPLGA IDH3G ASS1ENSG00000256407 TKLRRC4T DPYSL4PPA7 TNARS DPM1 AGL NR3C1 NCOA2 DLST CBR1 CYB5R4H2BFWTHIST1H2BDPYSL5I ITGAV PPARGC1A SERPING1TNFRSF10C MGST1 HADHASUCLG2 MTHFD2 DPYSL2IARS KDM1B AIM2NCK1 IL1R1 TLR4FABP4 APOA1 NDUFS8 C3AR1 SDHA CPS1 DPYSL3 EEF1E1 TP53BP2 JAK1 STAT3PTPRC CD33 EPRS COQ2 DARS MSRB2 FLNA IL5 MED27TLR2 MED31 MED29 ZC3H12A ACAT1 ATIC PARS2 GYS2 PRKCZITGA2B CD36 TLR6 CYC1ENSG00000258674 ACOX2TEN1 OGDH GMPSSHMT2 BST1 RASA1 STAT5A MYD88 IL1B FABP1MED2APOA28 UQCRFS1UQCRC1 WNT2B PAX5 WNT4 QDPR HSDL2 LDHAL6AIDH1SPR DHODH AIMP2 GFRA2 UBE2N LDLR PPARG ATP5B MT−CYB UQCRB AGPAT3 QARPAICSFDXRSSUCLA2 ACACB IDH3GBEB 1 AOAH C10orf11 IL4 STAT5BANGPT2 CYCS NDUFB2 P2RY13 CD163 WNT7A FAM129C ACADS RAB2PDHX4 FARSA FOS CD14 UQCRQ HP ACO2 DBTARST MDH1TYMPB YARSGPI AMY2A IL13 THRB MED10 NDUFAFNDUFS53 C3 CCL21 SCP2 IDH2MTHFD1LLARSDPYAIMPD 1 CASP1JAK3 CCL19 OXSM EHHADCS H PFKL PFKP CLEC4A RTN1 TBXAS1 IL2RB STAT1 CSF2MED18TRAFMED13L6 MED20 NDUFSPMPCB2 PDCD1 FZD2CXCL13SELL PDCD1LG2 UEVLD MARSFARS2 KARMS4A6AS DOK2 IL2RA MT−ND1 NDUFA4 CD83 ITGAL PCDH9 VDAC1 SHMT1 LDHC COX5B MT−ND4 CD46 P2RY14 CCR3 IL18BP TST ACOX3 DLAT IDH3LDHAL6BA UMPSCAD MASPHK31 IL18RAP IL18R1 STAT6 MED19 NDUFA8NDUFB9 NDUFAF6NDUFC1 CXCR1 LGALS3BP LDHBPFAS GYS1 PYGM ASGR1 SELP IL2RGIFNG NDUFA1 NDUFAF4 PARP14 STAP1 DNAJC10DHFR ACLGARLDHAGLDCYT PYGB MED11 NDUFAF1 NDUFS1 LAMP3 CCR2 ITGB2 CR1 FYB ACOX1MTHFR AMT XRCC4 UPP1 IL10RA FOXP3 IL18 APOC3 UQCR1NDUFB70 NDUFB8UQCRH NLRC4 TBX21 WNT3 NCFGRAP2 2 WNT1 PAK3 MCAT HSP90B1 ACACACANX PKLR BLVRB NDUFA1NDUFA33 NDUFC2 CXCR3 CLEC7A HESX1 HADH TKTL1SDHB C14orf15VTI1A CXADR9 AK5 FBXL5 IL15 NDUFS4 NDUFB10 CXCR5 FZD5 GRAP2 RARS RPE PNP PDSSPGM22 MAP4 ANGPT1 APOE NLRP3 MTTP NDUFA6 AIM2 TIMPPYCAR1 DHGS PCBD1 AKR7A2 HSD17B4HADHBBET1 ADAVPS52MOCSMDH13 SEC22A MSRB1 NDUFA5NDUFA12 NDUFB4 CD81 SELP GAS6 TYMS ADSPKMLDHTKD1 TKTL2 KCTD12 IL18BP IL4R ECSIT NDUFB1 CCR1 CXCL1CYBB2 VAV1 GIT1 GFPT1 PGM1 PYGL UQCRC2 NDUFS3 NDUFA11 PANX1 P2RX7 FASLGMPL CD36 CD300LF SDHC VAMP3 AMICA1 MT−ND2 NDUFA1NDUFAF20 CARD16 CCL3 IL27 GIT2 OGDHLHSPA5 STX16VPS51 DIAPH2 APOB IL1A NDUFV2 NDUFB6NDUFB3 ZAP70CPT1AACADM STX8 MAOA CD9 ENSG00000267855NDUFVNDUFA91 CXCR7 CCRANKRD225 EPOR FOSL1ERBB3 ASCL2 NAGA SELPLG NDUFV3NDUFA2 TMEM126B CXCR4 EBI3 TRAF1 DNAJB1 FASN CYB5R1 PSTPIP1 CARS2 NDUFAB1 NDUFB5 NDUFA7 TICAM1 ITGAX STAT6ITGAM ETV7 ENTPD1 LRRK2 GFPT2 AMY2B MT−ND3 NLRP1 CXCL10 WNT3ATRADDJAK3 WNT5A CDC42 STX12 IL13RA1 MT−ND5MT−ND6 FOSB NLRP3CCLPTPN5 IL186 CD40CD274 IRS2 STX7 SIGLEC7 NDUFS7 CEACAM1 THBS1 NDUFAF7 CXCL11 LAT MCM4 FYN DNA2 PRKCNT5EDERN1 USO1 GBP6 TNFRSF10B STAT4IL6R PAH RAD51 NAPA RBCK1 ULK1 PLOD1 NLRC4 LPA ACAD9 PTPN1 MMP9 ATF3 NFE2L3 MGLL GSTK1 VAV1 MOCS2 MCM5 RPA3 SLC9A9 NDUFAF5 CXCL9 CASP9 CCLIL12IFNGB HRASIGF1LEPRNGFR TSC2 MGST2 XRCC1LIG3 MAP3K7 BCL10 MS4A6A TIMMDC1NDUFB11 NDUFS6 MT−ND4L MB21D1 CASP8CASP1 FAS IGFBP1 PPARA PCNACREB1 DUT LIG4 ENSG00000255339 PARP9 TLR8 CYBAWNT2ICAM1 GHR NCF4 NFKBIA PNKP TNFSF13 C12orf44 CARD8 TNFRSF1CSF2 AMAPK9 PRLR GH1 AKT1 RAD52 TBC1D5 DIAPH1 COMT IFITTBK13 IKBKGIFNA2 PIK3CGVCAMCHUK1 CDC42 TP53BP2 MCM6 MSH2 IL1R2 TLR6 IL1ASTAT2NFATC2 PML FOS MEF2A MCM7 TP53ILK NHEJ1PYCARD ANXA6ULK2 SOCS1 WNT7BATF4ILTN8PDGFRBF MAPK8IL6 PRLSOSIGFBP31 PAK1 ORC2 WASF2 NUBPL CARD1NLRC7 5 IFITM1BST2 CD289ERBB4TLR4 BCL2 STAT5AEPO LCP2 ATXN7L3HNF1A MYD88 MS4A4E LY96 CD40LGIRF3 EGF NCOA1 FOS HDAC9 TRAF6 LY96 NOD1 IKBKB GAB1 DLL4 CFLAR KAT2A WASF3 BAIAP2 NAIP IFITGBP55 PIK3CA IL6ST DDX58 LCP2 RPA1 UBE2N NLRP3RB1CC1 NAIP IFI6 AXL IRF7 TYK2STAT3AKT1 ATM SAMHD1 PRKDC LDB1 CASP1USP22ATF6 BIRC2 ATG13 USP18 IRF1 STAT5B PTEN CDKN2A TAF9 ARHGEF6RXRA JUNKAT2B MCM2 WASF1 CASP7 ERBB2FCGR1CBL A NRAS MED1 NFKB1 MALT1 SAMD9L IRF9 TRAF6 NFKB1SOCSJUN3 CSF2RARICTOR MED20 TADA2B CREBIKBK5 G RTP4 PSMD12BCL3IFIH1 IRS1 MED1TADA29 A EP300 TRRAP IL1R1 APAF1 JAK2 CASP3 PIK3R1 MED28 PPARRBBPHIST1H2BG4 M H2AFSMARCA4V CYFIP2 PARP1RELB RELBIRCMYD82 8JAK1FOXO1 RPS6KB1SYK MAP3K7PIK3CDPTPN11 PPARGLEP FYB SUPT3H OBFC1 TAF10 PRKCBHAT1 RNF31 MX2 PSMC5 TRAF2TLR3 CREBBP FADDEGFR IGF2 CREBBP MTA2 PARVG TNFRSF13B MAVSISG20 UBE2D2NOS3 CCL11 TYMPSHC1IGF1FOXO3INSRR MED11 MED13L CEBPA NCOR2 HDAC2 NFKBPOLBCHD42 SLC22A18ANXA4 NCKAP1L IFI44L IFI27 TNFRSF10DMX1 BIRC3SKP2NFKBIIFNARA 1 MYC NCF1 MED13 MED27 CD3CEBPB6 HIST1H2BDRPA2 CARD9 ABI1 TRIM2GBP12 PSMA7IFIT1 RELA TNFRSF1IRAKTP531B MAPK1CYCS PIK3CB HIST2H2AC SUDSTLR43CHUK PARVB LIMS2 CRIM1 PSMD13 TNFSF10 UBE2N GRB2 MED4MED6 H2AFY TICAM1 NDUFS8 HERC6 NFKBCUL12 NOTCH1 NRG1 SORT1 RBBP7 RPA4 MEFV NCKAP1 NLRC4 GBP2PSMA5 PSME2 HSP90AA1HACEMTOR1 BAX MED23 MED29 MED24 HIST3H3CCNCHIST2H2AA3HIST1H2BKHIST1H2AD TRAF3 CYFIP1 BATF2 IFITXAF12 SUMO1 CEBPB MED1MED20 2NCOR1 H2AFXH2AFZ TNFRSF17 AIF1 TAB1 PIAS1 RARAHIST3H2BBHDAC3 HIST1H2AMTA1A S100A8 TNFSF13B BRK1 TRAF3 UBE2V1 EIF2AK2 MED16 HIST1H2BHIST1H2AN J LIMS1 RSAD2 XIAP CDKN1FCGR1AB MED30 CCDC101HIST1H2BJHIST2H2BE HIST1H2BA IFI35 PSMA3PSME4TRIM2SKP1FBXO35 2 FOSL2 GBPMDM24 LRRK2 MED14 CENPA SIN3A SKAP2 FZD2 IFI44 PSMB5 ISG1TNFRSF10A5 IFNGR1 MED31 LMO2 HDAC1 PSMB10 CKS1B MED9 HIST1H2BMED1HIST1H2B2 H L SIN3H2BFMB BIRC3 S100A9 HERC5 PSMB3 PSMD9OASRBX31 UBA52 KRAS MED18 CDK8 HIST1H2BO PARVA POMP PSMD8 OAS2 PSMC3OASL CDK2 RPS29 STAT1 MED15 CDK19 HIST1H2AC SSBP4HIST1H2AE FGD2 PSMD3 PSMC4IFITM3PSMD14 UBB IRAK4 H2AFY2 H2AFJ FAM105B SAMD9 FBXL3 PSMB7 PSMB9OASRBPJ1 PSMC6 EIF3A MED7 TADA3HIST1H2BFHIST1H2BBHIST2H2AB FCN1 LY6E PSMB2UBA7 PSMC2 PSMD10 RPS27A RPS14 MED21 PRAM1HIST2H2BFLDB2H2AFB1HIST1H2BARID4BE MXD1 EPSTI1 PSMDPLSCR12 TRIM63 RPS7 MED17 ENSG00000256206 PSMB8UBE2V2PSMDPSMB66PSMDPSME14 GART RPS6 HIST1H2AH HIST1H2BC RNF7 TCEB1PRKAG2 RPL35RPS4XRPS15RPS25 HIST1H2AHIST1H2BGK OXSM PSMA2UBE2L6PSMD7 PSMB1 EIF4EBP1 MED8 UBE2B UBE2RPS27LI HIST1H2AMHIST3H2A FGL2 MNDA AIM2 ADRM1PSMA8PSMD1 UBE2APSMA1PSMB1PSMA41 MDM4 RPS24RPL32 TSPO HIST1H2AB TRIM14 UMPSFBXW7 RPL26L1EIF2S3 MTA3 NFATC3 IFITM2 NFKBIPSMD11B RPL18 GNG4 GNG5 UCHL5 SHFMPSMA61 CAD EIF2AK4 RPS20RPS15A RPL37A TICAM1 PSMD5 CMPK2 EIF2S1 RPL10LRPS4Y2 NLRP1 RPS3PAICS RPL36A RPS21 GNAT2 GNG3 IL18 IL18BP PSMC1 FBXO6ANAPC11 PSMB4 RPS8EIF2S2 RPL36 FBXL19 RPS2RPS263 RPLRPL235 RPL38 MT−CYB NDUFS6 ENSG00000261884 GMPR2 RPL7RPS11 PRKAG1RPSRPL35A5 RPL3 DOCK1 NDUFB3 NDUFS8 PMSA2 USP14 RPS10 RPS16 ACAD9 TLR1 RNF213GMPS RPS27RPL13A RPL28 IL18R1 TAP1 RPS3A RPL18A RPL13RPL34 BST1 GNGT2 MAP3K7 CASP1 NLRP3 PNPT1 RPL1RPL49 RPL24 DVL1 ROR1 NDUFB7 NLRC4 IL18RAP RPL15RPS4YRPL271 RPL31 BCAR1 PXN MYD88 CPS1 RPL36AL RPL8 RPL21 RET NDUFAF1 IL4 PRKAG3 RPL11RPS2 RPL26 GNB3 UQCRHMT−ND3 CTPS1 NME4 RPS9 RPL27A RPL6 MTHFD1, CARS2, TST MAPK10 NDUFC2 IL1R2 FOS BIRC2 CMPK1 RPS19RPS12 RPL37 TLR2 TRAF3 GCHFR IMPDH2 PFAS RPL14 NDUFAF7 IL1R1 RPS28 RPL12 RPS18 RPLP2 EIF5 GNG13 LRP5 ENSG00000258674 MT−ND4 IL1A RPL10 GNB4 WNT6 NDUFA7 NDUFB9 FOXP3 IL2RA PYCARD GCH1 DPYSL3 DPYD WNT10B NDUFA13 TRAF6 ARAF LY96 UPP1 IMPDH1RPL9RPL30 NDUFB6NDUFAF6 NDUFA9NDUFS1 IL15 WARS ANXA6 GNB1 GNG2 AXIN1 UQCRB NDUFA4 IL1B SIGLEC7 WNT1 CYCS NDUFS5 IL13RA1 IL13LCK IKBKG TLR6 CRMP1 DPYSL5 SCO2 GNG7 WNT3AWNT2B WNT7A NDUFAF5 IFNG CDA WNT10A GSK3B NDUFB1 MT−ND2 CD14 CD9 TLR4 MAPK14 Level 1 BCL2PIK3CA GMPR DPYS NCK1 NDUFS7UQCRC2 STAT6 BIRC3 DPYSL4 AIMP2 CTNNB1 FZD5 NDUFA10 IL5 EEF1E1 NDUFB11 SOS1 CSF2 JUNERBB2 CDK2 DPYSL2 PSTPIP1 TARS2 GDNF WNT5B NDUFB4NDUFAF3NDUFB8 IL10RABAX DUT COMT FZD1 RYK KREMEN1 NDUFV2 ATM NT5EERN1 PARD3 MAPK9GNAO1 FZD4 UQCRFS1 IL2RG EGFR RABGAP1L WNT11MAPK8 FZD2 NDUFAB1 NDUFA5 SELP IL2RB IL2 RELA TP53 ATP11A MSRA LRP6 NDUFAF2 ITGB3 IL4R AKT1 KARS RACPARD6A1 MT−ND6 MYC STAT3 ASS1 FARSARARS IARS2MSH2 DKK1 WNT8A NDUFV1 ANGPT2 LRRC47 WNT2 NDUFA1NDUFV3 ITGAV STAT1 FZD9 WNT9A NDUFA12 ENSG00000267855 PMPCB PDSS2 NARS TYMP CHEK2RB1RAF1 MDM2 PNPMTR FARSB PRKCI CDC42 NDUFS3ENSG00000255339COX5BMT−ND4L ITGA2B STAT5B BAK1 TP53BP2 AGL TKTL1 ENTPDADA 1 NDUFB10 ENSG00000259753 HRASPTPRC UBE2N MARS PARS2 DVL2 SOST MT−ND1NDUFA2NDUFS2 UQCR10 CRK FYN PCNA PYGL AMYARST ADSL APC DKK4 NDUFB5 CYC1 CDKN1AJAK1 GZMA MDM4 LRRK2, NFE2L3 MOCS2HSP90B1 AMY2BCARS2 MTRR WNT8B HIF1A JUND DHFTARSR MSRB2 YES1 RASA1ANGPT1 SRC CREB1 GCSH LDHBMOCS3 WNT4 DOK2 AIMP1 QARS DNAJC10LDHAL6B FLNA MAPKAPK2 WNT5A ROR2DVL3 NDUFA6 ZAP70TARSL2 PFKPKML VDAC1 UQCRC1 BRAF PRKDC SPR PDSS1 HSPA5TYMS ATIC PPAOTCT TSPO DKK2 NDUFB2 ECSITTMEM126BNDUFS4NDUFA8 RAPGEF1 PAK1 QDPR TST IARS CPS1 PGM2LDHA NDUFA11NDUFAF4 SELPLG JAK3 STAT5A UPP1 UMPS TPI1 WNT16 MT−ND5 PTEN CDKN2A SAMHD1 PAICS GPI NDUFA3 APOE MTHFD2 PFASPGM1 MTHFFDX1R CYB5A ARRB2 THBS1TEK RAD51 LARSMTHFD2L EPRS SUCLG2 Level 1 WNT9B NDUFC1 MS4A4E AK5 PYGM MSRB1 UQCRQ PCDH9 MDH1RPELDHAL6AIDH3B WNT3 GFRA2 GBE1 AMY1AAGPATSHMTGFPT132 CSGFPT1SUCLA2 PAK2 NUBPL ATP5B MS4A6A SRGAP2 SHMTACOX2 MTHFD11 PKLRL ACACBDNAJB1 FTCDTKT WNT7B TIMMDC1 TLN1 CAD GART DARS IDH3ASRGL1G DPYS DLAT IDH2IDH3A PRKCZ X58, HERC5, IFI44L, SAMD9L AGPAT6 ACACA TKTL2FDXR GYS1GLDC MTHFD1 GMPS OGDHLHK3 ACAA2AMY2A ACLYFARS2DPYD HSDL2 CYB5R3 FZD2 NLRC4 HADHB HADH SUCLG1ACO2 WNT2B CPPED1 ACADS PFKP HADHASDHB MDH1EHHADHLDHBC UEVLD NDUFS8 CD300LF PYGB OXSM IDH1 CYB5R1 COQ2 DLST CRMP1 RCAN1 SCP2 DBDPYSL2T DHODHSDHC DPYSL4 EIF2AK2, DD WNT4 PCBD1 ACADM MDH2 TICAM1 FPGS TRAF3 MX2 DLL4 ACOX2 OGDHPDHX PFKM CYB5R4 SKAP2 ST20−MTHFS DHTKDTALDO11SDHA DPYSL5 HLCS ACAT1 NCF4 MGLL GYS2 ACOCBR11ACAT2 ENSG00000256407DPYSL3 MB2IDI HSD17B4 WNT7BFZD2WNT7A FASN CARD16 WNT3 ALG5 OXNAD1CYB5R2 CALML4 WNT3A SRGAP2 CPT1A CYB5RL GNG4 NDUFV1 APOE PAX5 ACOX3ACAA1MCAT GNG7 LY96 LY96 MX2 PARP14 SDHD EIF2AK2 USP18 FCRL2 FYB IKBKG IFI27 IFITM3 WNT5A WNT2 CD14 NDUFS8 STAT2 HGS AXL WNT11 TICAM1 DDX58 IFI44 PDGFRB LRRK2 NAGA NDUFS7 NOD1 TBK1 IFITM2RTP4 WNT1 CD274 IFI35 GAB1 ERBB4 EBI3 NFATC2 GNB3 IL27 CYBB ERBB3 NDUFS2 TLR6 TRAF6 CLEC7A TYK2 MAVS C1QIRF9C IFIT3 CD46 CEACAM1 ERBB2 NDUFS4 MX1 GBP1 C1S IFNGR1IL6ST JAK3 ATF4 TSC2 NDUFB8 TLR6 IFNAR1 IRF3IFIT1 IFI6 PLSCR1 LCP2 IRAK1 GNG13 TLR1 ISG20 HESX1 TIMP1VCAMCDC421 SOCS3 NRG1 TNFSF10 NOTCHJAK21 EGFRSOS1MTOR PLOD1 GNGT2 UQCRFS1 CD289 IL18 XAF1 CFI LGALS3BPPRLRPTPN6 PTPN1 NFE2L3 TBXAS1 FBXL5 UQCRH GAS6 GRB2 STAT5B MAP3K7 C10orf11 IFIH1 IRF7RSAD2 HERC5 STAT4 AKT1 Level 1 NDUFA12 AIM2 TRIM22 FAM129C MYD88 NLRC4 CD83 GBP5 BST2 C1R GHCYBA1 FOXOLEPR1 TAB1 MAPK9RICTOR NDUFS1 NDUFA5 TLR2 STAT1IFIT2 MDM4 LEPKRAS IL8 PTPN11 STAT5A ETV7 GNAT2 TLR8 IRAK4 PARP9 CFH CXCR4 FASLG CD40MAPK8PIK3CA VAV1 CXCL12STAT3 HRASHSP90AA1 TLR4 PRKAG1 GNAO1 MT−CYB MYD88 TLR3 PML IGFBP3 CASP3 PTENINSR FZD4 IL1R1 CASP1 IFITM1 IFI44L IL6R TNFRSF1A SAMD9L BATF2 PIK3R1 EIF4EBP1IL6 UQCRC1 FCGR1B TRIM25 PIAS1 IRS1 MMP9 MT−ND1 IRF1 IFNA2 SHC1NRAS EGF PIK3CBPIK3CDPIK3CGCREBBP SOCS1 CD36 MT−ND4L CYCS TLR4 CXCL10CXCL11 NGFRBCL2GHR NDUFA8 IL1R2 ITGAX CBL IFNGICAMIGF11 RPS6KB1XIAGRAP2PCCL11TBX21 TS GNG5 IL1R1 CLEC4A LAMPIL18BP3 GBP4 SERPINGIGFBP11 IL1BSTAT6MDM2JAK1 TRAF1 CCL5 GBP2 C1orf162 PDCD1LG2CEBPB EPO IKBKB CCL2 JUN FOS T PYCARD PDCD1 IRS2 CSF2 NCF2 COX5B NLRP3 MNDA GBP6 CD163 TNFRSF10A MYCMAPK1 GNG3 CCR2 PRLEPOR CDKN2A PRKAG2IKBKG GNB1 NDUFS3 ATP5B IL1B Level 2 TRIM14 FCGR1ASIGLEC1 IGF2 IGF1RITGAM SELL UQCRB CXCR3 CXCL13 NCF1 NOS3SYK APAF1 MAP3K7 CCL3 HP MPL ITGB2CYCS FOSL2 UQCRC2 BAX SDHD WNT5A IL18 FGL2 SELP CHUK FOXOPPARG3 P2RX7 COMT AMY2B P2RY14 FAS CASP9TRAF6PARP1 CFLAR PANX1CASP7 MTHFD1, CARS2 AMY1A CCL19 CXCL9 CCR3 ATF3 FOSL1 CCR5CASP8 CARD8PYCARD NAIP FDX1 GNG2 NDUFA7 CXCR5 C1QB PMPCB TP53BP2 STAP1 TNFRSF10B ENSG00000258674 CCL8 TNFRSF10D UQCRQ CASP1 FADD ATM CARD17GCH1 ST20−MTHFSCYB5A ADSL IL1A CCL21 MS4A6A CSF2RA IL1A ITGAL SELPLGNLRP1 MTHFD1 NLRP3 CCR1 BCL3 HSPA5 FZD5 P2RY13 SORT1 TRADD MTRR PDSS2 GBE1 GNB4 NDUFV2 C3 TNFRSF10C FARSA CALML4 CYC1 NDUFA4 CR1 ZC3H12AFOSB ATIC FARSB C3AR1 C1QA SCO2 ERN1 LRRC47 NDUFA9 CXCR7 MOCS3 MTHFR ACACB FZD2 APOL1 FPGS FTCD TARS AGL CD81 ASS1 GFPT2 SAMHD1 PLOD1 CARD16 MSH2 SIGLEC7 DPYS SHMT1AIMP1 TARSL2 IL18BP NLRP1 MTHFD2 IARS PYGM SHMT2 OTC RPE CXCR1 RAD51 PSTPIP1 PYGB AIM2 MTHFD2LDHFR EPRS ACACA ROR1 ENSG00000255339 CPS1 LARS ACO1 GPI PYGL FZD2 NDUFB10 UQCR10 PCDH9 AMT MARS PARS2 ASRGL1 GART DPYSL2 ATP11A TKTL2 NLRC4 MTPAICSR Level 2 DPYSL4 UMPS NARS DPYSL3 MOCS2 PPAT GMPSRARS KARS PDSS1CAD QARS LRRK2, NFE2L3 DHODHMSRA TARS2 C10orf11 HK3PGM1 TPILDHB1 NDUFS8 EIF2AK2, DDX58, HERC5, IFI44L, SAMD9L TYMS YARSFARS2 DNAJB1 IL18RAP MTHFD1L ADA DNAJC10 CS TYMP PFAS IARS2 GYS2 PFKL FGD2 DUT AK5 PNP ALG5 MDH1 MDH1B ZAP70 DARS PKLR LDHAL6APKM NFE2L3 GYS1 HSP90B1 EEF1E1 CD14 CRIM1 PRKAG2 PGM2 GNB1 NLRC4 CRMP1 TKT OGDH TYMP DPYSL5 GFPT1 LDHAPFKM AIMP2 CARS2 MAP3K7 NDUFA12 PARP9 LDHAL6B IRF3 CEACAM1 NRAS PRKAG1 QDPRANXA6 TALDO1 IFI44 EIF4EBP1 AGPAT3NT5E MDH2 SOS1 FBXL5 NDUFA9 PLSCR1 IFITM3 AGPAT6 ENTPD1 MT−ND1 IFI44L SAMD9L IRF9 UPP1 LDHC TKTL1 UQCRQ HERC5 ETV7 NCF4 HRAS PFKP APOE ERBB3 IRS1 IGFBP1 XAF1 EIF2AK2 AXL RPS6KB1 BST1 PYCARD STAT1 IFIH1MX2 INSR CPPED1 IFI6 STAT2 CDC42 RICTOR MTOR LRRK2 PCBD1 NDUFB10 NDUFS8 PIK3CD WNT5A IL1B IFI35 PARP14 HGS TSC2 FZD4 USP18 SKAP2 IRF7 GBP2 IFNA2 IGF2 FCRL2 Level 2 MB21D1 VAV1 MAPK1 PIK3R1 TST TRIM22FCGR1B IGFBP3 IFIT3 RSAD2 IGF1R ERBB2 FZD5 NDUFS4 GBP5 GRB2 KRAS NDUFA7 ISG20 MX1 IFITM1 IGF1 LCP2 SYK PTEN PIK3CA ERBB4 IL1A DDX58 IFIT1 TYK2 MGLL NDUFV2 BST2 SHC1 PDGFRBEGFR CARS2 RTP4 IRF1 CBLPIK3CB NDUFS1 IL1R2 AIM2 IFI27MAVS IRS2 TS IFITM2 NDUFA4 TRIM25GBP6 GAB1 PML IFIT2 FYB NRG1 MT−ND4L GBP1 TBK1 GRAP2 T IL18 TNFSF10 TRIM14 WNT1 FAM129C FZD2 ENSG00000258674NDUFV1 NLRP1 IFNAR1 EGF NDUFS2 SERPING1 GAS6 LGALS3BP MTHFD1 Level 3 GBP4 ROR1 BATF2 NLRC5 GYS2 IL18RAP FZD2 NLRP3 FBXL5 NDUFB8NDUFA8 NDUFA5 CASP1 CYB5A TST COMT GYS1 FARSB EIF2AK2, DDX58, HERC5, IFI44L, SAMD9L LRRK2, NFE2L3 MDH1B AMT RAD51 NARS ACO1 ENSG00000255339 NLRC4 ATIC PDSS2 MSRA LDHAL6A MTHFR YARS RPE TARS2 TKT IL18BP KARS LDHB IFITM1 PPAT LRRC47 MDH1 TKTL1 ROR1 TYMS ASRGL1 FARS2 LDHAL6B PLSCR1 HERC5 FAM129C MTHFD1L MTR MOCS2 GMPS DARS NDUFS8 PDSS1 MDH2 LDHC IFI44 FTCD RARS CARS2 CS TKTL2 PFKL FZD5 EIF2AK2 FARSA DNAJC10 NLRC4 RSAD2 MX1 PRKAG1 LRRK2 QARS STAT2 PRKAG2 RICTOR MTHFD1 DHFR USP18SAMD9L SHMT2 LARS EEF1E1 IFIH1 FPGS MOCS3 MARS AIMP1 AIMP2 Level 3 PARP14 GPI TALDO1 NDUFA5 NDUFS2 IFITM3 TSC2 MTOR ADSL IARS2 EPRS PKLR EIF4EBP1 MTHFD2L PSTPIP1 NLRP3 IFIT1 SHMT1 PARS2 PKM OGDHTPI1 ENSG00000258674 IL1B DDX58 IFI35 IARS PFKM TYMP PIK3CB MTHFD2 GFPT2 WNT5A NDUFA7 PIK3CA TARSL2 BST2 IFI6 IRS1 NFE2L3 CAD PARP9 IFIT2 INSR Level 3 MTRR LDHA PFKP PTEN FZD2 NDUFS1 TNFSF10 STAT1 IFI44L KRAS PIK3CD ASS1 UQCRQ MX2 IFI27 ST20−MTHFS XAF1 IGF1R MTHFD1 NLRC4 RPS6KB1 GFPT1 TARS NLRP1 ISG20 CPPED1 AIM2 IGFBP1 IGF1 HSP90B1
CRIM1 IRS2 CARS2 NDUFS8 Level 4 RTP4 IFITM2 IGFBP3 NDUFV2 MT−ND4L EGF
IFIT3 TS GAS6 IGF2 MOCS2 PYCARD T
NDUFB8 ENSG00000255339 EIF2AK2, DDX58, HERC5, IFI44L, SAMD9L SERPING1 MOCS3 RAD51 LGALS3BP DARS AIMP2 NDUFB10 NDUFA4 TNFSF10 LRRK2, NFE2L3 QARS PARP9 MDH1 MT−ND1 MTHFD1L ASRGL1 LDHAL6B NDUFA8 ST20−MTHFS MARS FARSA USP18 HERC5 IFIT1 PARP14 PIK3CA EIF4EBP1 TARS2 LDHAL6A FAM129C IARS TST MDH2 DNAJC10 PIK3CB MTHFD1 EEF1E1 FBXL5 PKLR RTP4 MX1 Level 4 IFIH1 DDX58 LRRK2 PPAT OGDH IARS2 KARS RARS TPI1 STAT1 PIK3CD PTEN Level 4 GPI SAMD9L FTCD MTHFD2L AIMP1 CS RSAD2 IFI44L RICTOR MTHFD2 ACO1 CARS2 PKM CRIM1 IFI44 KRAS IGF1R PLSCR1 LARS MDH1B EIF2AK2 ADSL MTHFD1 NARS RPS6KB1 NFE2L3 FARSB IRS1 INSR TS
T
CARS2 EIF2AK2, DDX58, HERC5, IFI44L, SAMD9L LRRK2, NFE2L3
HERC5 MTHFD2L TARS2 FBXL5 DDX58 EIF4EBP1 RPS6KB1 ST20−MTHFS ACO1 OGDH IFI44 PTEN IARS2 CARS2 SAMD9L IRS1 FTCD ADSL RICTOR IFI44L MTHFD2 Level 5 ASRGL1 EIF2AK2 LRRK2 LDHAL6B TST KRAS Level 5 MTHFD1 PLSCR1 FARSA FARSB IGF1R MTHFD1L LDHAL6A INSR CRIM1 NARS PPAT NFE2L3 MTHFD1 CARS2 TS
EIF2AK2, DDX58, HERC5, IFI44L, SAMD9L T NFE2L3
SAMD9L NARS LRRK2 OGDH IFI44L ADSL TARS2 EIF4EBP1 MTHFD1L
IGF1R EIF2AK2 HERC5 NFE2L3 CARS2 LRRK2 RICTOR RPS6KB1 Level 6 MTHFD1 TST Level 6 DDX58 LDHAL6B
IFI44 PTEN MTHFD2 FARSB INSR PPAT IARS2
LDHAL6A