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Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases
University of Massachusetts Medical School eScholarship@UMMS Open Access Articles Open Access Publications by UMMS Authors 2020-03-11 Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases Brett D. Story Auburn University Et al. Let us know how access to this document benefits ou.y Follow this and additional works at: https://escholarship.umassmed.edu/oapubs Part of the Animal Experimentation and Research Commons, Investigative Techniques Commons, Musculoskeletal Diseases Commons, Nervous System Diseases Commons, Translational Medical Research Commons, and the Veterinary Medicine Commons Repository Citation Story BD, Miller ME, Bradbury AM, Million ED, Duan D, Taghian T, Faissler D, Fernau D, Beecy SJ, Gray- Edwards H. (2020). Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases. Open Access Articles. https://doi.org/10.3389/fvets.2020.00080. Retrieved from https://escholarship.umassmed.edu/oapubs/4183 Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 License. This material is brought to you by eScholarship@UMMS. It has been accepted for inclusion in Open Access Articles by an authorized administrator of eScholarship@UMMS. For more information, please contact [email protected]. REVIEW published: 11 March 2020 doi: 10.3389/fvets.2020.00080 Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases Brett D. Story 1,2, Matthew E. Miller 1, Allison M. Bradbury 3, Emily D. Million 4, Dongsheng Duan 4,5,6,7, Toloo Taghian 8, Dominik Faissler 9, -
ISAG Programme Abs Am.Indd
30 S0001 – S0016 Invited Speaker Abstracts INVITED SPEAKERS S0001–S0016 31 S0001 The power of comparative genetics and genomics S0004 Finding the causal variant in selective sweeps Kerstin Linbald-Toh. Elinor Karlsson. Broad Institute, USA; Uppsala University, Sweden. Broad Institute, Cambridge, MA, USA. The human genome contains hundreds of regions with patterns of genetic variation that refl ect recent, positive natural selection, yet for most the underlying gene and S0002 Using intra-species variation to understanding basic the advantageous mutation remain unknown. We have developed a method, the biology Composite of Multiple Signals (CMS), that, by combining multiple different tests for natural selection, increases our resolution by up to 100-fold. By applying CMS to the International Haplotype Map, we localize hundred signals, reducing the candidate Ewan Birney. region for each to just ~50-100kb. In many cases, we can identify the precise gene EMBL Outstation – Hinxton, European Bioinformatics Institute, Welcome Trust Genome and polymorphism targeted by selection. This includes genes involved in infectious Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom. disease susceptibility, skin pigment, metabolism, and hair and sweat. Nearly half Quantitative genetics based on large, outbred populations has had a long history in of the ~200 regions we localized contain no genes at all, and 13 contain long, non- both animal breeding and human disease studies. It is one of the few techniques coding RNAs, which can regulate nearby genes. In several regions we signifi cantly which one can apply to understand a complex phenotype when nothing else is known associate variants under selection with the expression of nearby genes. -
Collie Eye Anomaly in Australian Kelpie Dogs in Poland Natalia Kucharczyk1, Anna Cislo-Pakuluk1 and Peter Bedford2*
Kucharczyk et al. BMC Veterinary Research (2019) 15:392 https://doi.org/10.1186/s12917-019-2143-y CASE REPORT Open Access Collie Eye Anomaly in Australian Kelpie dogs in Poland Natalia Kucharczyk1, Anna Cislo-Pakuluk1 and Peter Bedford2* Abstract Background: To report the occurrence of choroidal hypoplasia in the Australian Kelpie breed in Poland, the affected dogs testing positive for the Collie Eye Anomaly NHEJ1 gene mutation. Case presentations: Choroidal hypoplasia (CH) was initially diagnosed in a young female Australian Kelpie presented for routine ophthalmological examination prior to breeding. Indirect ophthalmoscopy revealed tigroid fundi bilaterally with areas of abnormally arranged choroidal vasculature temporal to the optic disc. These lesions had the appearance of the choroidal hypoplasia diagnostic for Collie Eye Anomaly, a genetically determined disease seen most commonly in Collie types. The DNA based test for the NHEJ1 gene mutation that is confirmatory for Collie Eye Anomaly proved the dog to be homozygous for this mutation. Twenty one other related dogs were subsequently examined genetically, the dam proving to be affected and eight others were shown to be carriers. Conclusions: This report demonstrates that Collie Eye Anomaly is present in a Polish bred Australian Kelpie line and as such breeders in this country and those importing dogs or semen internationally should be aware of other possible cases. Keywords: Australian Kelpie, Choroidal hypoplasia, Collie Eye Anomaly, NHEJ1 gene Background and intraocular haemorrhage are also described, but Collie Eye Anomaly (CEA) is a congenital canine pleo- although potentially blinding, these features are of low in- morphic ocular disease characterized by two main lesions, cidence [1–5]. -
1 Studies of the Fonni's Dogs from Sardinia Show Commonalities
Genetics: Early Online, published on August 12, 2016 as 10.1534/genetics.116.192427 Studies of the Fonni’s Dogs from Sardinia show commonalities between development of pure breeds and population isolates Dayna L. Dreger*, Brian W. Davis*, Raffaella Cocco†, Sara Sechi†, Alessandro Di Cerbo‡, Heidi G. Parker*, Michele Polli§, Stefano P. Marelli§, Paola Crepaldi§, Elaine A. Ostrander* *Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 †Dipartimento di Medicina Veterinaria, Sezione Clinica Medica, University di Sassari, Italy ‡School of Specialization in Clinical Biochemistry, G. d’Annunzio University, Chieti, Italy §Dipartimento di Medicina Veterinaria, Universita di Milano, Italy Whole-genome sequence was produced for this study from a single Fonni’s Dog, submitted to the Sequence Read Archive (PRJNA318762) for release upon manuscript acceptance. Previously published whole-genome sequence obtained from the Sequence Read Archive is listed in Table 1 with corresponding accession numbers. Genotype data from the Illumina CanineHD array has been submitted to Gene Expression Omnibus (GSE83160). 1 Copyright 2016. RUNNING TITLE Fonni’s Dog mirrors human population isolates KEY WORDS dog, whole genome sequence, demography, population structure CORRESPONDING AUTHOR Elaine A. Ostrander, Ph.D. National Human Genome Research Institute, National Institutes of Health 50 South Drive, Building 50, Room 5351, Bethesda MD, 20892 Phone: 301 594 5284 FAX 301-480-0472 [email protected] 2 ABSTRACT The island inhabitants of Sardinia have long been a focus for studies of complex human traits due to their unique ancestral background and population isolation reflecting geographic and cultural restriction. Population isolates share decreased genomic diversity, increased linkage disequilibrium, and increased inbreeding coefficients. -
Dog Breed DNA and Survey Results: What Kind of Dog Is That? the Dogs () DNA Results Survey Results
Maddie's Shelter Medicine Program College of Veterinary Medicine (https://sheltermedicine.vetmed.ufl.edu) Dog Breed DNA and Survey Results: What Kind of Dog is That? The Dogs () DNA Results Survey Results Dog 01 Top Responses 25% Toy Fox Terrier Golden Retriever 25% Harrier Pomeranian 15.33% Anatolian Shetland Sheepdog Shepherd Cocker Spaniel 14% Chinese Crested Chihuahua Dog 02 Top Responses 50% Catahoula Leopard Labrador Retriever Dog American Staffordshire 25% Siberian Husky Terrier 9.94% Briard No Predominant Breed 5.07 Airedale Terrier Border Collie Pointer (includes English Pointer) Dog 03 Top Responses 25% American Labrador Retriever Staffordshire German Shepherd Dog 25% German Shepherd Rhodesian Ridgeback 25% Lhasa Apso No Predominant Breed 25% Dandie Dinmont Terrier American Staffordshire Terrier Dog 04 Top Responses 25% Border Collie Wheaten Terrier, Soft Coated 25% Tibetan Spaniel Bearded Collie 12.02% Catahoula Leopard Dog Briard 9.28% Shiba Inu Cairn Terrier Tibetan Terrier Dog 05 Top Responses 25% Miniature Pinscher Australian Cattle Dog 25% Great Pyrenees German Shorthaired Pointer 10.79% Afghan Hound Pointer (includes English 10.09% Nova Scotia Duck Pointer) Tolling Retriever Border Collie No Predominant Breed Dog 06 Top Responses 50% American Foxhound Beagle 50% Beagle Foxhound (including American, English, Treeing Walker Coonhound) Harrier Black and Tan Coonhound Pointer (includes English Pointer) Dog 07 Top Responses 25% Irish Water Spaniel Labrador Retriever 25% Siberian Husky American Staffordshire Terrier 25% Boston -
Genomic Characterization of the Three Balkan Livestock Guardian Dogs
sustainability Article Genomic Characterization of the Three Balkan Livestock Guardian Dogs Mateja Janeš 1,2 , Minja Zorc 3 , Maja Ferenˇcakovi´c 1, Ino Curik 1, Peter Dovˇc 3 and Vlatka Cubric-Curik 1,* 1 Department of Animal Science, Faculty of Agriculture, University of Zagreb, 10000 Zagreb, Croatia; [email protected] (M.J.); [email protected] (M.F.); [email protected] (I.C.) 2 The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK 3 Biotechnical Faculty Department of Animal Science, University of Ljubljana, SI-1000 Ljubljana, Slovenia; [email protected] (M.Z.); [email protected] (P.D.) * Correspondence: [email protected]; Tel.: +385-1-239-4008 Abstract: Balkan Livestock Guardian Dogs (LGD) were bred to help protect sheep flocks in sparsely populated, remote mountainous areas in the Balkans. The aim of this study was genomic charac- terization (107,403 autosomal SNPs) of the three LGD breeds from the Balkans (Karst Shepherd, Sharplanina Dog, and Tornjak). Our analyses were performed on 44 dogs representing three Balkan LGD breeds, as well as on 79 publicly available genotypes representing eight other LGD breeds, 70 individuals representing seven popular breeds, and 18 gray wolves. The results of multivariate, phylogenetic, clustering (STRUCTURE), and FST differentiation analyses showed that the three Balkan LGD breeds are genetically distinct populations. While the Sharplanina Dog and Tornjak are closely related to other LGD breeds, the Karst Shepherd is a slightly genetically distinct population with estimated influence from German Shepard (Treemix analysis). Estimated genomic diversity was high with low inbreeding in Sharplanina Dog (Ho = 0.315, He = 0.315, and FROH>2Mb = 0.020) and Citation: Janeš, M.; Zorc, M.; Tornjak (Ho = 0.301, He = 0.301, and FROH>2Mb = 0.033) breeds. -
HERDING BREEDS ELIGIBLE to COMPETE in ASCA STOCKDOG TRIALS Ref: the Atlas of Dog Breeds of the World - Bonnie Wilcox, DVM & Chris Walkowic
ASCA STOCKDOG PROGRAM RULES – JUNE 2014 APPENDIX 6: HERDING BREEDS ELIGIBLE TO COMPETE IN ASCA STOCKDOG TRIALS Ref: The Atlas of Dog Breeds of the World - Bonnie Wilcox, DVM & Chris Walkowic Breed Country of Origin Breed Country of Origin Australian Cattle Dog Australia Greater Swiss Mountain Dog Switzerland Australian Kelpie Australia Hairy Mouth Heeler USA Australian Shepherd USA Hovawart Germany Belgian Laekenois Belgium Iceland Dog Iceland Belgian Malinois Belgium Kerry Blue Terrier Ireland Belgian Sheep Dog Lancashire Heeler Great Britain (Groenendael) Belgium Lapinporokoira Belgian Tervuren Belgium (Lapponian Herder) Finland Bouviers Des Flandres Belgium Malinois Belgian Bergamasco Italy McNab USA Bernese Mtn Dog Switzerland Miniature Australian Shepherd USA Beauceron France Mudi Hungary Briard France North American Shepherd USA Bearded Collie Great Britain Norwegian Buhund Norway Border Collie Great Britain Old English Sheep Dog Great Britain Blue Lacy USA Picardy Shepherd France Catahoula Leopard Dog USA Polish Owczarek Nizinny Poland Canaan Dog Israel Puli Hungary Cao de Serra de Aires Pumi Hungary (Portuguese Sheep Dog) Portugal Pyrenean Shepherd France Croatian Sheep Dog Croatia Rottweiler Germany Cataian Sheep Dog Spain Samoyed Scandinavia Collie Great Britain Schapendoes Corgi (Dutch Sheepdog) Netherlands Cardigan Welsh Great Britain Shetland Sheep Dog Great Britain Pembroke Welsh Great Britain Soft Coated Wheaten Terrier Ireland Dutch Shepherd: Netherlands Spanish Water Dog Spain English Shepherd USA Swedish Lapphund Sweden Entlebucher Mountain Dog Switzerland Tibetan Terrier China Finnish Lapphund Finland Vasgotaspets Sweden German Shepherd Dog Germany White Shepherd USA German Coolie/Koolie Australia 74 . -
AKC Education Webinar Series: FSS/Miscellaneous Questions and Answers
AKC Education Webinar Series: FSS/Miscellaneous Questions and Answers 1. Can an FSS Parent Club offer an ATT Test? If the Parent Club is licensed to hold any event, it may offer an ATT Test. 2. For a domestically evolving breed that started with an independent registry for 20 years, then accepted into UKC for an additional 20 years, can these two be combined to qualify for the 40 years required to be considered into FSS, or must the 40 be done within the same registry body? The history of a breed having a registry for a minimum of 40 years can be merged as described, staff will review to determine if it would meet the parameters required. 3. Does AKC have reciprocity with UKC? AKC has open registration with individual breeds with that are registered by UKC. A breed requesting to be enrolled in the AKC FSS based upon UKC recognition would have reciprocity, if it meets the number of years being in existence, until the breed becomes AKC recognized. At which time the individual breeds may request to keep the studbook open for UKC registered dogs. 4. Is it a good practice to submit all of the required data to AKC in one PDF electronically to FSS as a final submission, once all criteria is met for the ease of processing? The FSS Department keeps track of required data, meeting minutes maybe a PDF, the other requirements need to be in different formats. Breed Standard needs to be a word document, membership list needs to be in an Excel as provided. -
ACE Appendix
CBP and Trade Automated Interface Requirements Appendix: PGA August 13, 2021 Pub # 0875-0419 Contents Table of Changes .................................................................................................................................................... 4 PG01 – Agency Program Codes ........................................................................................................................... 18 PG01 – Government Agency Processing Codes ................................................................................................... 22 PG01 – Electronic Image Submitted Codes .......................................................................................................... 26 PG01 – Globally Unique Product Identification Code Qualifiers ........................................................................ 26 PG01 – Correction Indicators* ............................................................................................................................. 26 PG02 – Product Code Qualifiers ........................................................................................................................... 28 PG04 – Units of Measure ...................................................................................................................................... 30 PG05 – Scientific Species Code ........................................................................................................................... 31 PG05 – FWS Wildlife Description Codes ........................................................................................................... -
Journal of PADS 46
№46 October 2015 JOURNAL of the International Society for Preservation of Primitive Aboriginal Dogs From the Publisher... Dear members of PADS and readers of our Journal, In this 46th issue, Alikhon Latifi and Latif Latifi tells us about the origin, way of life, working purpose and future perspective of the sheepdogs of Tajikistan. It is noteworthy that these dogs still live and breed like a natural population, without a breed standard and selection for winning shows. We also publish the third part of an article by Elena Potseluyeva, in which she continues to inform us about the history of Chukotka Sleddogs. Sincerely yours, Vladimir Beregovoy 2 To preserve through education……….. In This Issue… SHEEPDOGS OF TAJIKISTAN ............................................................... 4 HISTORICAL AND CLIMATIC PREREQUISITES OF THE APPEARANCE OF THE POPULATION OF SLED DOGS OF THE SHORELINE OF THE CHUKOTKA PENINSULA (PART 3) ............ 31 LIST OF MEMBERS ................................................................................ 37 MEMBERSHIP APPLICATION ............................................................. 45 To preserve through education……….. 3 Sheepdogs of Tajikistan Alikhon Latifi and Latif Latifi Tajikistan I have created the dog, oh Zarathustra , I – Ahura Mazda, The coated in its own coat and shoed in its own shoes, Alert, with sharp teeth one, Sharing the role of man for the protection of the world. Thus I, Ahura Mazda, Appointed the dog to guard against the Turanian tribe, As long as bastion of truth remains, As long as the world exists. From Avesta Videvdad, Fragard 13. Dog. Strophe 39. Introduction The sheepdogs of Tajikistan are a distinct but not isolated population of sheepdogs of Central Asia. These dogs are characterized by a considerably large size of body (63-75 cm at the shoulders), an aggressive character, excellent guarding qualities and an unyielding perseverance in protecting property and livestock from thieves and predators. -
Gundogs Australian National Kennel Council
AUSTRALIAN NATIONAL KENNEL COUNCIL LTD NOTE: Any breed highlighted below has the Pre-1987 Standard GROUP 1 – TOYS GROUP 2 – TERRIERS GROUP 3 - GUNDOGS Affenpinscher KC Airedale Terrier KC Bracco Italiano KC Australian Silky Terrier ANKC American Hairless Terrier AKC Brittany FCI Bichon Frise KC American Staffordshire Terrier AKC Chesapeake Bay Retriever KC Cavalier King Charles Spaniel KC Australian Terrier ANKC Clumber Spaniel KC Chihuahua (Long Coat) KC Bedlington Terrier KC Cocker Spaniel KC Chihuahua (Smooth Coat) KC Border Terrier KC Cocker Spaniel (American) AKC Chinese Crested Dog KC Bull Terrier KC Curly Coated Retriever KC Coton De Tulear (show from 1/3/16) FCI Bull Terrier (Miniature) KC English Setter KC English Springer Spaniel English Toy Terrier (Black & Tan) KC Cairn Terrier KC KC Field Spaniel KC Griffon Bruxellois KC Cesky Terrier FCI Flat Coated Retriever KC Havanese KC Dandie Dinmont Terrier KC German Shorthaired Pointer FCI Italian Greyhound KC Fox Terrier (Smooth) KC German Wirehaired Pointer FCI Japanese Chin KC Fox Terrier (Wire) KC Golden Retriever KC King Charles Spaniel KC German Hunting Terrier FCI Gordon Setter KC Lowchen KC Glen of Imaal Terrier KC Hungarian Vizsla FCI Maltese Irish Terrier KC KC Hungarian Wirehaired Vizsla FCI Miniature Pinscher Jack Russell Terrier KC ANKC Irish Red & White Setter KC Papillon KC Kerry Blue Terrier KC Irish Setter KC Pekingese KC Lakeland Terrier KC Irish Water Spaniel KC Pomeranian KC Manchester Terrier KC Italian Spinone KC Pug KC Norfolk Terrier KC Labrador Retriever KC -
Commencing Implementation of a Genetic Evaluation System for Livestock Working Dogs by C
Commencing implementation of a genetic evaluation system for livestock working dogs by C. M. Wade, D. van Rooy, E. R. Arnott, J. B. Early and P. D. McGreevy June 2021 Commencing implementation of a genetic evaluation system for livestock working dogs by C. M. Wade, D. van Rooy, E. R. Arnott, J. B. Early and P. D. McGreevy June 2021 i © 2021 AgriFutures Australia All rights reserved. ISBN 978-1-76053-135-5 ISSN 1440-6845 Commencing implementation of a genetic evaluation for livestock working dogs Publication No. 20-117 Project No: PRJ-010413 The information contained in this publication is intended for general use to assist public knowledge and discussion and to help improve the development of sustainable regions. You must not rely on any information contained in this publication without taking specialist advice relevant to your particular circumstances. While reasonable care has been taken in preparing this publication to ensure that information is true and correct, the Commonwealth of Australia gives no assurance as to the accuracy of any information in this publication. The Commonwealth of Australia, AgriFutures Australia, the authors or contributors expressly disclaim, to the maximum extent permitted by law, all responsibility and liability to any person, arising directly or indirectly from any act or omission, or for any consequences of any such act or omission, made in reliance on the contents of this publication, whether or not caused by any negligence on the part of the Commonwealth of Australia, AgriFutures Australia, the authors or contributors. The Commonwealth of Australia does not necessarily endorse the views in this publication.