DOCSLIB.ORG

Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Hemorrhoids

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Hemorrhoids Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Hemorrhoids Chemical Activity Count (+)-ALLOMATRINE 1 (+)-ALPHA-VINIFERIN 2 (+)-CATECHIN 4 (+)-CYANIDANOL-3 1 (+)-EUDESMA-4(14),7(11)-DIENE-3-ONE 1 (+)-GALLOCATECHIN 1 (+)-HERNANDEZINE 1 (+)-ISOCORYDINE 1 (+)-PSEUDOEPHEDRINE 1 (-)-16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 (-)-ALPHA-BISABOLOL 2 (-)-ARGEMONINE 1 (-)-BETONICINE 1 (-)-BORNYL-CAFFEATE 1 (-)-BORNYL-FERULATE 1 (-)-BORNYL-P-COUMARATE 1 (-)-DICENTRINE 1 (-)-EPIAFZELECHIN 1 (-)-EPICATECHIN 1 (-)-EPIGALLOCATECHIN-GALLATE 2 (1'S)-1'-ACETOXYCHAVICOL-ACETATE 1 (15:1)-CARDANOL 1 (E)-4-(3',4'-DIMETHOXYPHENYL)-BUT-3-EN-OL 2 1,7-BIS-(4-HYDROXYPHENYL)-1,4,6-HEPTATRIEN-3-ONE 1 1,8-CINEOLE 3 10-ACETOXY-8-HYDROXY-9-ISOBUTYLOXY-6-METHOXYTHYMOL 2 10-DEHYDROGINGERDIONE 1 Chemical Activity Count 10-GINGERDIONE 1 11-DEHYDROPAPYRIOGENIN 1 11-DEOXYGLYCYRRHETINIC-ACID 1 11-HYDROXY-DELTA-8-THC 1 11-HYDROXY-DELTA-9-THC 1 12,118-BINARINGIN 1 12-ACETYLDEHYDROLUCICULINE 1 13',II8-BIAPIGENIN 2 13-OXYINGENOL-ESTER 1 16,17-DIHYDROXY-16BETA-KAURAN-19-OIC 1 16-HYDROXYINGENOL-ESTER 1 2'-HYDROXY-FLAVONE 1 2'-O-GLYCOSYLVITEXIN 1 2-BETA,3BETA-27-TRIHYDROXYOLEAN-12-ENE-23,28-DICARBOXYLIC-ACID 1 20-DEOXYINGENOL-ESTER 1 22BETA-ESCIN 1 24-METHYLENE-CYCLOARTANOL 2 3,3'-DIMETHYLELLAGIC-ACID 1 3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER 2 3,4-SECOTRITERPENE-ACID-20-EPI-KOETJAPIC-ACID 1 3-ACETYLACONITINE 3 3-BETA-ACETOXY-20,25-EPOXYDAMMARANE-24-OL 1 3-BETA-HYDROXY-2,3-DIHYDROWITHANOLIDE-F 1 3-HYDROXY-FLAVONE 2 3-N-BUTYL-PHTHALIDE 1 3-O-ACETYLOLEANOLIC-ACID 1 3-OXO-11-ALPHA-HYDROXYOLEAN-12-ENE-30-OIC-ACID 1 2 Chemical Activity Count 3-OXO-11-ALPHA-METHOXYOLEAN-12-ENE-30-OIC-ACID 1 3-OXO-OLEAN-9(11),12-DIENE-30-OIC-ACID 1 4'-DIMETHYLPODOPHYLLOTOXIN 1 4'-HYDROXY-FLAVONE 1 4-VINYL-GUAIACOL 2 5,6-DEHYDROKAWAIN 1 5,7-DIHYDROXY-FLAVONE 1 5,7-DIMETHOXYFLAVONE 1 5-BETA-HYDROXYECDYSTERONE 1 5-DEOXYINGENOL-ESTER 1 5-HYDROXY-FLAVONE 1 6,7-DIMETHOXYCOUMARIN 1 6,7-DIMETHYLAESCULETIN 3 6,7-DIMETHYLESCULETIN 2 6-(ALPHA-APIOFURANOSYL)-(1->6)-O-BETA-D-GLUCOPYRANOSYL-OXY)-RUBROFUSARIN 1 6-DEHYDROGINGERDIONE 1 6-DEOXYJACAREUBIN 1 6-GINGERDIONE 1 6-GINGEROL 3 6-HYDROXY-FLAVONE 1 6-HYDROXY-FLAVONE-GLUCOSIDE 1 6-O-(2''-ACETYL-3'',4''-O-DI-P-METHOXYCINNAMOYL-ALPHA-L-RHAMNOPYRANOSYL)-CATALPOL 1 6-O-(4''-ACETYL-2'',3''-O-DI-P-METHOXYCINNAMOYL-ALPHA-L-RHAMNOPYRANOSYL)-CATALPOL 1 6-SHOGAOL 2 7,8-DIHYDROXYFLAVONE 1 7-HYDROXY-FLAVONE 1 7-HYDROXY-FLAVONE-GLUCOSIDE 1 3 Chemical Activity Count 7-METHOXYCOUMARIN 2 7-O-ANGELYLHELIOTRIDINE 1 8-ACETYLHARPAGIDE 1 8-O-CINNAMOYLHARPAGIDE 2 ABRIN 1 ABRINE 1 ACACETIN 1 ACANTHOIC-ACID 2 ACETYL-11-KETO-BETA-BOSWELLIC-ACID 2 ACETYL-BETA-BOSWELLIC-ACID 1 ACETYL-CHOLINE 1 ACETYLALEURITOLIC-ACID 1 ACETYLCYSTEINE 1 ACETYLDELGRANDINE 1 ACETYLSALICYLIC-ACID 2 ACETYLSHIKONIN 2 ACONINE 2 ACONITINE 4 ACTEOSIDE 1 ACTINIDOLES 2 ADENOSINE 2 AESCIN 4 AESCULETIN 4 AESCULETOL 1 AESCULIN 3 AESCULOSIDE 1 AFFINISINE 1 4 Chemical Activity Count AGARIC-ACID 1 AGATHISFLAVONE 1 AIPHANOL 1 AJMALICINE 1 AJOENE 3 AKUAMMIDINE 1 AKUAMMINE 1 ALANTOLACTONE 1 ALISOL-A-MONOACETATE 1 ALISOL-B-MONOACETATE 1 ALISOL-C-MONOACETATE 1 ALIZARIN 1 ALIZARIN-3-METHYLIMINO-DIACETIC-ACID 1 ALKANNIN 2 ALLANTOIN 1 ALLICIN 2 ALLIIN 1 ALLITHIAMIN 1 ALLOCRYPTOPINE 1 ALOCUTIN-A 1 ALPHA-AMYRIN 5 ALPHA-AMYRIN-ACETATE 2 ALPHA-AMYRIN-PALMITATE 1 ALPHA-BISABOLOL 2 ALPHA-BOSWELLIC-ACID 2 ALPHA-CURCUMENE 1 ALPHA-LINOLENIC-ACID 1 5 Chemical Activity Count ALPHA-PELTATIN 1 ALPHA-PEROXYACHIFOLIDE 1 ALPHA-PINENE 1 ALPHA-SPINASTEROL 1 ALPHA-TERPINEOL 1 AMARALIN 1 AMAROGENTIN 1 AMBELLINE 1 AMENTOFLAVONE 3 AMERICANIN 1 AMURENSINE 1 AMURINE 1 AMYGDALIN 1 ANAGYRINE 1 ANANDAMIDE 1 ANDROGRAPHOLIDE 2 ANDROGRAPHOSIDE 1 ANETHOLE 1 ANGELICIN 1 ANISATIN 1 ANISODAMINE 2 ANISODINE 1 ANNOMONTINE 2 ANTHOCYANINS 2 ANTHOCYANOSIDE 2 ANTHRANILIC-ACID 1 ANTIRRHINOSIDE 1 6 Chemical Activity Count APIGENIN 3 APIGENIN-7-GLYCOSIDE 1 APIGENIN-7-O-GLUCOSIDE 1 APIGENIN-DIMETHYL-ETHER 1 APOCYNIN 1 AR-TURMERONE 2 ARACHIDONIC-ACID 1 ARBORININE 1 ARBUTIN 1 ARCAPILLIN 1 ARGEMONINE 1 ARISTOLOCHIC-ACID 2 ARMILLARIEN-A 1 AROMATICIN 1 ARTABSIN 1 ARTECANIN 1 ARTEMETIN 2 ARVENOSIDE-A 1 ASCARIDOLE 1 ASCORBIC-ACID 4 ASIATICOSIDE 2 ASPERULOSIDE 1 ASPIRIN 2 ASPIRIN (ACETYLSALICYLIC-ACID; NOT NATURAL) 2 ASTRAMEMBRANIN-I 1 ASTRINGENIN 2 ATRACTYLENOLIDE 2 7 Chemical Activity Count ATRACTYLENOLIDE-I 2 ATRACTYLENOLIDE-II 2 ATRACTYLENOLIDE-III 2 ATRACTYLOCHROMENE 2 ATRACTYLON 2 ATROPINE 2 AUCUBIN 3 AXILLARIN 1 AZULENE 1 BACOSINE 2 BAICALEIN 5 BAICALEIN-5,6,7-TRIHYDROXY-FLAVONE 1 BAICALIN 3 BAOHUOSIDE-1 1 BARBATOSIDE-A 2 BARBATOSIDE-B 2 BARTSIOSIDE 1 BASSIC-ACID 1 BAVACHININ 2 BAYACHININE 2 BEIWUTINE 1 BELLIDIFOLIN 1 BELLIDIFOLINE 1 BENZALDEHYDE 1 BENZOIC-ACID 1 BENZOIN 1 BENZOXAZINOIDS 1 8 Chemical Activity Count BENZOYLACONINE 2 BENZOYLCATALPOL 1 BENZYL-ALCOHOL 1 BERBAMINE 2 BERBERASTINE 6 BERBERINE 7 BERBERINE-SULFATE 1 BERGAPTEN 1 BERGENIN 1 BETA-AESCIN 2 BETA-AMYRIN 5 BETA-AMYRIN-ACETATE 2 BETA-BOSWELLIC-ACID 2 BETA-CAROTENE 1 BETA-DAMASCENONE 2 BETA-ECDYSTERONE 1 BETA-ESCIN 2 BETA-EUDESMOL 1 BETA-HIMACHALINE 1 BETA-PELTATIN 1 BETA-PINENE 1 BETA-SANTALENE 1 BETA-SITOSTEROL 3 BETA-SITOSTEROL-3-O-BETA-D-GLUCOPYRANOSIDE 1 BETA-TURMERONE 2 BETAINE 1 BETONICINE 1 9 Chemical Activity Count BETULIN 1 BETULINIC-ACID 3 BIS-(4-HYDROXY-CINNAMOYL)-METHANE 1 BIS-DESMETHOXYCURCUMIN 1 BISABOLOXIDE 1 BOCCONINE 1 BOEHMEROL-ACETATE 2 BOLDINE 3 BORJATRIOL 1 BORNEOL 3 BORRECAPINE 1 BORRELINE 1 BOSWELLIC-ACID 5 BOWDICHIONE 1 BRADYKININASE 3 BRAZILIN 2 BREVIFOLIN 1 BROMELAIN 4 BROUSSOAURONE-A 1 BROUSSOCHALCONE-A 2 BROUSSOFLAVONOL-F 1 BRYONOLIC-ACID 1 BUDMUNCHIAMINES 1 BULLEYACONITINE-A 2 BUPLEURIN 2 BUTEIN 1 BUTYLIDENE-PHTHALIDE 2 10 Chemical Activity Count CACTISIN 1 CAFESTOL 1 CAFFEIC-ACID 5 CAFFEOYLMARIC-ACID 1 CAFFEOYLTARTARIC-ACID 1 CALOPHYLLIN-B 1 CALOPHYLLOLIDE 1 CAMPHOR 2 CANNABICHROMENE 1 CANNABIDIOL 2 CANNABIGEROL 1 CANNABINOL 1 CANNFLAVIN 1 CANNIPRENE 1 CAPILLARISIN 1 CAPSAICIN 5 CARANINE 1 CARBENOXOLONE 1 CARBOXYATRACTYLOSIDE 1 CARDOL 1 CARNOSINE 1 CARNOSOL 2 CARPESTEROL 1 CARVACROL 4 CARYOPHYLLENE 3 CARYOPHYLLENE-OXIDE 2 CASSAIDINE 2 11 Chemical Activity Count CASSAINE 1 CASSAMINE 2 CATECHIN 5 CATHINE 1 CATHINONE 2 CEPAENE 1 CEPHARAMINE 2 CEPHARANOLINE 2 CEPHARANTHINE 3 CHAKSINE 1 CHAMAZULENE 2 CHELERYTHRINE 2 CHELIDONINE 1 CHIKUSETSUSAPONIN 1 CHIKUSETSUSAPONIN-V 1 CHLOROGENIC-ACID 3 CHLOROGENIN 1 CHOLINE 2 CHOLINE-SALICYLATE 1 CHONDROCURINE 1 CHRYSANTHEMOL 1 CHRYSIN 1 CHRYSIN-5,7-DIHYDROXYFLAVONE 1 CHRYSOSPLENIN 1 CHRYSOSPLENOL 1 CHYMOTRYPSIN 1 CINCHOPHYLLAMINE 2 12 Chemical Activity Count CINCHOPHYLLINE 1 CINNAMALDEHYDE 4 CINNAMIC-ACID 2 CINNAMIC-ACID-BORNYL-ESTER 2 CINNAMOYLHISTAMINE 1 CIRSILINEOL 2 CIRSIMARITIN 2 CIS-COMMUNIC-ACID 1 CIS-METHYLSULPHINOTHIOIC-ACID-S-1-PROPENYLESTER 1 CIS-N-PROPYLSULPHINOTHIOIC-ACID-S-1-PROPENYLESTER 1 CIS-SPIROETHER 2 CITRAL 1 CLITORIACETAL 1 CNICIN 1 CNIDILIDE 1 COCAINE 1 CODEINE 2 COIXENOLIDE 1 COIXOL 1 COLCHICINE 2 COLCHICOSIDE 1 CONDURANGIN 1 CONESSINE 1 CONIFERYL-ALDEHYDE 2 CONJUGATED-LINOLEIC-ACID 1 COPPER 2 COPPER-SALICYLATE 2 13 Chemical Activity Count COPTISINE 1 CORILAGIN 1 CORNINE 1 CORONARIDINE 1 CORYBULBINE 1 CORYDALINE 1 CORYNANTHINE 1 COUMARIN 5 COUMINGINE 2 CREOSOTE 1 CROTALOBURINE 3 CRYOGENINE 1 CRYPTOAESCIN 1 CRYPTOLEPINE 1 CUCURBITACIN-B 1 CULARINE 1 CUPARENE 1 CURCUMIN 6 CURCUMINOIDS 1 CYANIDIN-3-O-GLUCOSIDE 2 CYCLEANINE 3 CYCLOALLIIN 1 CYCLOARTENOL 1 CYCLOBUXINE-D 1 CYCLOSADOL 1 CYNARIN 1 CYTISINE 1 14 Chemical Activity Count D-NORPSEUDOEPHEDRINE 1 DAIDZEIN 1 DAIJISON 1 DAMASCEINE 1 DAMASCENINE 1 DAPHNETIN 1 DAURICINE 3 DEHYDROCURDIONE 3 DEHYDROCYCLOGUANANDIN 1 DELAVACONITINE 1 DELTA-3-CARENE 1 DELTA-8-THC 1 DELTA-9-THC 1 DEMETHOXYCURCUMIN 1 DEMETHYLTETRANDRINE 1 DENDROBINE 1 DEOXYGOMOSIN-A 1 DESMETHOXYANGONIN 2 DESMODIN 1 DESOXYPODOPHYLLOTOXIN 1 DI-P-COUMAROYL-METHANE 1 DIANOSIDE 1 DIANOSIDE-A 1 DIAZEPAM 1 DICENTRINE 1 DIGITOXIN 1 DIHYDROCANTHINE 1 15 Chemical Activity Count DIHYDROHELENALIN 2 DIHYDROHELENALIN-ESTERS 1 DIHYDROKAWAIN 4 DIHYDROMETHYSTICIN 4 DIMETHYLAMINE-SALICYLATE 1 DIOSCINE 2 DIOSCORINE 2 DIOSGENIN 2 DIOSMIN 5 DIRCA-PHENOLIC-GLUCOSIDE-5 1 DITETRAHYDROPALMATINE 1 DL-TETRAHYDROPALMATINE 1 DREGAMINE 1 ECDYSTERONE 1 ECGONINE 1 EDPETILINE 1 EICOSAPENTAENOIC-ACID 2 ELAEOCARPIDINE 1 ELAEOCARPINE 2 ELAIDIC-ACID 1 ELLAGIC-ACID 3 EMETINE 1 EMODIN 2 EN-YN-DICYCLOETHER 1 ENT-16A-,17-DIHYDROXY-KAURAN-19-OIC-ACID 1 EPHEDRINE 3 EPHEDROXANE 2 16 Chemical Activity Count EPI-PROCURCUMENOL 1 EPICATECHIN 1 EPSILON-VINIFERIN 1 ERIODICTYOL 1 ERYTHROPHLAMINE 2 ERYTHROPHLEINE 1 ESCIN 4 ESCULETIN 4 ESCULIN 3 ESTRAGOL 1 ETHANOL 1 ETHYL-SALICYLATE 1 ETHYLENE 1 EUCALYPTOL 1 EUGENOL 6 EUGENYL-ACETATE 1 EUGLOBAL 1 EUPAFORMOSANIN 1 EUPAHYSSOPIN 2 EUPATOLIDE 1 EUXANTHONE 1 EVODIAMINE 3 EVODOL 2 FAGARAMIDE 1 FALCARINDIOL 1 FALCARINOL 1 FANGCHINOLINE 1 17 Chemical Activity Count FARADIOL 2 FARADIOL-MONOESTER 2 FENUGREEKINE 1 FERULIC-ACID 3 FERULOYL-4-HYDROXYCINNAMOYL-METHANE 1 FERULOYLHISTAMINE 1 FETIDINE 1 FICIN 1 FINACONITINE 1 FISETIN 1 FLAVOKAWAIN-B 2 FLAVONE 3 FORMALDEHYDE 1 FORMIC-ACID 1 FORSKOLIN 1 FRAXIN 1 FRIEDELAN-3-BETA-OL 2 FRIEDELIN 1 FRITILLARINE 1 FUMARILINE 1 FUMOFICINALNE 1 GALANGIN 2 GALANGIN-3,5,7-TRIHYDROXYFLAVONE 1 GALANTHAMINE 1 GALLIC-ACID 5 GALLOCATECHIN-(4ALPHA->8)-EPIGALLOCATECHIN 1 GALLOCATECHIN-(4ALPHA->8)-GALLOCATECHIN 1 18 Chemical Activity Count GALLOCATECHIN-(4ALPHA->8)-GALLOCATECHIN-(4ALPHA->8)-GALLOCATECHIN 1 GAMMA-BOSWELLIC-ACID 1 GAMMA-TOCOPHEROL 2 GAULTHERIN 1 GELSEMINE 1 GENIPOSIDE 1 GENISTEIN 1 GENTIANAINE 1 GENTIANAMINE 1 GENTIANIDINE 1 GENTIANINE 3 GENTIOPICROSIDE
Load more

Recommended publications
  • Dr. Duke's Phytochemical and Ethnobotanical Databases List of Chemicals for Lyme Disease (Chronic)
    Dr.
    [Show full text]
  • INVESTIGATION of NATURAL PRODUCT SCAFFOLDS for the DEVELOPMENT of OPIOID RECEPTOR LIGANDS by Katherine M
    INVESTIGATION OF NATURAL PRODUCT SCAFFOLDS FOR THE DEVELOPMENT OF OPIOID RECEPTOR LIGANDS By Katherine M. Prevatt-Smith Submitted to the graduate degree program in Medicinal Chemistry and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Doctor of Philosophy. _________________________________ Chairperson: Dr. Thomas E. Prisinzano _________________________________ Dr. Brian S. J. Blagg _________________________________ Dr. Michael F. Rafferty _________________________________ Dr. Paul R. Hanson _________________________________ Dr. Susan M. Lunte Date Defended: July 18, 2012 The Dissertation Committee for Katherine M. Prevatt-Smith certifies that this is the approved version of the following dissertation: INVESTIGATION OF NATURAL PRODUCT SCAFFOLDS FOR THE DEVELOPMENT OF OPIOID RECEPTOR LIGANDS _________________________________ Chairperson: Dr. Thomas E. Prisinzano Date approved: July 18, 2012 ii ABSTRACT Kappa opioid (KOP) receptors have been suggested as an alternative target to the mu opioid (MOP) receptor for the treatment of pain because KOP activation is associated with fewer negative side-effects (respiratory depression, constipation, tolerance, and dependence). The KOP receptor has also been implicated in several abuse-related effects in the central nervous system (CNS). KOP ligands have been investigated as pharmacotherapies for drug abuse; KOP agonists have been shown to modulate dopamine concentrations in the CNS as well as attenuate the self-administration of cocaine in a variety of species, and KOP antagonists have potential in the treatment of relapse. One drawback of current opioid ligand investigation is that many compounds are based on the morphine scaffold and thus have similar properties, both positive and negative, to the parent molecule. Thus there is increasing need to discover new chemical scaffolds with opioid receptor activity.
    [Show full text]
  • Opportunities and Pharmacotherapeutic Perspectives
    biomolecules Review Anticoronavirus and Immunomodulatory Phenolic Compounds: Opportunities and Pharmacotherapeutic Perspectives Naiara Naiana Dejani 1 , Hatem A. Elshabrawy 2 , Carlos da Silva Maia Bezerra Filho 3,4 and Damião Pergentino de Sousa 3,4,* 1 Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa 58051-900, Brazil; [email protected] 2 Department of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA; [email protected] 3 Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil; [email protected] 4 Postgraduate Program in Bioactive Natural and Synthetic Products, Federal University of Paraíba, João Pessoa 58051-900, Brazil * Correspondence: [email protected]; Tel.: +55-83-3216-7347 Abstract: In 2019, COVID-19 emerged as a severe respiratory disease that is caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The disease has been associated with high mortality rate, especially in patients with comorbidities such as diabetes, cardiovascular and kidney diseases. This could be attributed to dysregulated immune responses and severe systemic inflammation in COVID-19 patients. The use of effective antiviral drugs against SARS-CoV-2 and modulation of the immune responses could be a potential therapeutic strategy for Citation: Dejani, N.N.; Elshabrawy, COVID-19. Studies have shown that natural phenolic compounds have several pharmacological H.A.; Bezerra Filho, C.d.S.M.; properties, including anticoronavirus and immunomodulatory activities. Therefore, this review de Sousa, D.P. Anticoronavirus and discusses the dual action of these natural products from the perspective of applicability at COVID-19.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,692,728 B2 Weipert Et Al
    USOO6692728B2 (12) United States Patent (10) Patent No.: US 6,692,728 B2 Weipert et al. (45) Date of Patent: Feb. 17, 2004 (54) POLYESTERS BASED ON HYDROXY FATTY (52) U.S. Cl. ......................... 424/59; 424/497; 424/489; ACDS AND LOWER HYDROXY ALKYL 424/70.11; 424/78.37; 424/78.08; 514/785; ACDS AND USES THEREOF 560/171; 560/172; 560/176; 560/183; 525/400 (58) Field of Search .......................... 424/59, 497, 489, (75) Inventors: Paul David Weipert, High Point, NC 424/70.11, 78.37; 514/785; 560/172,176, (US); Bharat B. Desai, Spartanburg, 183; 525/400 SC (US) (73) Assignee: Ethox Chemicals LLC, Greenville, SC ") References Cited (US) U.S. PATENT DOCUMENTS ( c: ) Notice: Subject to any disclaimer, the term of this 5,502,116 A 3/1996 Noda ......................... 525/415 patent is extended or adjusted under 35 5,614,576 A * 3/1997 Rutherford et al. ......... 524/270 U.S.C. 154(b) by 0 days. 5,851,937 A * 12/1998 Wu et al. ................... 442/394 * cited by examiner (21) Appl. No.: 10/388,426 (22) Filed: Mar 17, 2003 Primary Examiner Sabiha Qazi 9 (74) Attorney, Agent, or Firm-Isaac A. Angres (65) Prior Publication Data (57) ABSTRACT US 2003/0175222 A1 Sep. 18, 2003 The present invention provides biodegradable polyesters Related U.S. Application Data based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for (62) Division of application No. 09/805,894, filed on Mar. 15, Sunscreens, skin lotions and by themselves are also useful as 2001, now Pat.
    [Show full text]
  • Antioxidants and Second Messengers of Free Radicals
    antioxidants Antioxidants and Second Messengers of Free Radicals Edited by Neven Zarkovic Printed Edition of the Special Issue Published in Antioxidants www.mdpi.com/journal/antioxidants Antioxidants and Second Messengers of Free Radicals Antioxidants and Second Messengers of Free Radicals Special Issue Editor Neven Zarkovic MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editor Neven Zarkovic Rudjer Boskovic Institute Croatia Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Antioxidants (ISSN 2076-3921) from 2018 (available at: https://www.mdpi.com/journal/ antioxidants/special issues/second messengers free radicals) For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03897-533-5 (Pbk) ISBN 978-3-03897-534-2 (PDF) c 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Special Issue Editor ...................................... vii Preface to ”Antioxidants and Second Messengers of Free Radicals” ................ ix Neven Zarkovic Antioxidants and Second Messengers of Free Radicals Reprinted from: Antioxidants 2018, 7, 158, doi:10.3390/antiox7110158 ...............
    [Show full text]
  • A Review on Amentoflavone
    Indo American Journal of Pharmaceutical Research, 2017 ISSN NO: 2231-6876 A REVIEW ON AMENTOFLAVONE * Aroosa Siddique , Madiha Jabeen, Osman Ahmed Department of Pharmaceutical Chemistry, Deccan School of Pharmacy, Hyderabad, T.S. ARTICLE INFO ABSTRACT Article history Amentoflavone, is a bioflavonoid constituent of some of flora which includes ginkgo biloba, Received 06/02/2017 hypericum perforatum. It can have interaction with many medicinal drugs by using being a Available online potent inhibitor of CYP3A4 and CYP2C9 which are enzymes chargeable for the metabolism 28/02/2017 of some drugs in the body. Flavonoids exhibit a extensive variety of activities including antioxidant, antiviral, Antibacterial and anticancer pastime. As formerly we showed that Keywords amentoflavone is an activator of hPPARγ. Human PPARγ (hPPARγ) regulates the Amentoflavone, proliferation, apoptosis, and various human most cancers cells. Activated hPPARγ has both Flavonoid, tumor suppressor and tumor promoter. To affirm the mechanism of motion of amentoflavone Synthetic, in most cancers cells, we analyzed whether or not amentoflavone remedy affects the RSV, Hpparγ, appearance of hPPARy the use of opposite transcription polymerase chain response and CYP3A4 & CYP2C9. actual time quantitive PCR. Amentoflavone is synthesized with the aid of way of three techniques i.e natural, semi synthetic and synthetic methods. Among this synthetic method is widely used industrially. Application of the Suzuki-Miyaura response within the synthesis of flavonoids, is of vital magnificence of natural merchandise, is studied. Amentoflavone and three different flavonoids were separated from the ethanol extract of Selaginella sinensis. Amentoflavone show strong antiviral pastime in opposition to respiratory syncytial virus (RSV). The cytotoxic interest of amentoflavone is examined against 5 human most cancers cell strains (MCF-7, A549, HeLa, MDA-MB231, and PC3) treating with tetrazolium- primarily based colorimetric MTT assay.
    [Show full text]
  • Evidências Sobre Tratamentos Clínicos Conservadores Para Doença
    www.rbmfc.org.br ARTIGOS DE REVISÃO Evidências sobre tratamentos clínicos conservadores para doença hemorroidária Evidence on conservative clinical treatments for haemorrhoids Evidencias sobre tratamientos clínicos conservadores para la enfermedad hemorroidal Fernanda da Silva Barbosa. Universidade Federal de Santa Catarina (UFSC). Florianópolis, SC, Brasil. [email protected] (Autora correspondente) Jardel Corrêa de Oliveira. Secretaria Municipal de Saúde (SMS). Florianópolis, SC, Brasil. [email protected] Charles Dalcanale Tesser. Universidade Federal de Santa Catarina (UFSC). Florianópolis, SC, Brasil. [email protected] Resumo Objetivo: o objetivo desta avaliação de tecnologia em saúde foi analisar as evidências sobre tratamentos clínicos conservadores para doença Palavras-chave: Avaliação da Tecnologia hemorroidária utilizáveis na Atenção Primária à Saúde. Métodos: buscou-se no Embase, LILACS e MEDLINE via Pubmed por meta-análises, revisões Biomédica sistemáticas e ensaios clínicos controlados e aleatorizados, publicados até dezembro de 2012, sem limite de linguagem. Os estudos deveriam avaliar Terapêutica os efeitos dos tratamentos clínicos conservadores (fibras ou laxantes, flavonoides, analgésicos, corticosteroides, banhos de assento ou pomadas de Hemorroidas nitroglicerina) comparados a placebo ou entre si. Os desfechos considerados foram: melhora global dos sintomas, sangramento, prurido, dor, prolapso Atenção Primária à Saúde e efeitos adversos. Resultados: uma meta-análise demonstrou que fibras promovem melhora global dos sintomas e do sangramento e diminuem a recorrência após procedimentos ambulatoriais. Três meta-análises mostraram a eficácia de flavonoides para sangramento agudo e pós-operatório, melhora global dos sintomas, exsudação perianal e recorrência após episódio agudo. Não houve diferença estatística para prurido, dor, prolapso ou efeitos adversos nos dois casos. Flavonoides do tipo rutosídeos reduziram sintomas em gestantes, apesar da insuficiência dos dados para comprovar sua segurança.
    [Show full text]
  • Infraspecific Variability in the Flavonoid Composition of Artemisia Vulgaris L
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Acta Bot. Croat. 65 (1), 13–18, 2006 CODEN: ABCRA25 ISSN 0365–0588 Infraspecific variability in the flavonoid composition of Artemisia vulgaris L. MILENA NIKOLOVA* Institute of Botany, Bulgarian Academy of Sciences, 23, Acad. G. Bonchev str. 1113 Sofia, Bulgaria Surface flavonoid profiles in forty populations of Artemisia vulgaris L. (Asteraceae) were analyzed. The major constituents observed in the leaf exudates were methylated flavonoid aglycones based mainly on quercetin. Three infraspecific flavonoid chemotypes were de- termined, the chrysosplenetin (quercetagetin 3,6,7,3’-tetramethyl ether) chemotype, the artemetin (quercetagetin 3,6,7,3’,4’-pentamethyl ether) chemotype and chemotype with- out these two compounds. Most of the populations corresponded to these chemotypes. Key words: Artemisia vulgaris, Asteraceae, flavonoid aglycones, chrysosplenetin, arte- metin, chemotype Introduction Surface flavonoid aglycones are often used in chemotaxonomic studies on Asteraceae at the generic and species level (VALANT-VETSCHERA and WOLLENWEBER 1996, WOLLEN- WEBER et al. 1997, STEVENS et al. 1999). Recent articles showed that a flavonoid pattern couldalsobespecificforachemotype(REP^ÁK et al. 1999, WILLIAMS et al. 2000, MARTONFI et al. 2001, VIEIRA et al. 2003). The species of the genus Artemisia (Asreraceae) have been extensively surveyed for their surface flavonoid constituents (WOLLENWEBER et al. 1989, VALANT-VETSCHERA and WOLLENWEBER 1995, WOLLENWEBER and VALANT-VETSCHERA 1996). Artemisia vulgaris L (Asteraceae) is a perennial polymorphic species, widespread in temperate areas (South Europe, North Africa, North America and Asia). Simple flavonol methyl ethers have been reported for West-European populations (VALANT-VETSCHERA et al.
    [Show full text]
  • Supplementary Materials Evodiamine Inhibits Both Stem Cell and Non-Stem
    Supplementary materials Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70 Seung Yeob Hyun, Huong Thuy Le, Hye-Young Min, Honglan Pei, Yijae Lim, Injae Song, Yen T. K. Nguyen, Suckchang Hong, Byung Woo Han, Ho-Young Lee - 1 - Table S1. Short tandem repeat (STR) DNA profiles for human cancer cell lines used in this study. MDA-MB-231 Marker H1299 H460 A549 HCT116 (MDA231) Amelogenin XX XY XY XX XX D8S1179 10, 13 12 13, 14 10, 14, 15 13 D21S11 32.2 30 29 29, 30 30, 33.2 D7S820 10 9, 12 8, 11 11, 12 8 CSF1PO 12 11, 12 10, 12 7, 10 12, 13 D3S1358 17 15, 18 16 12, 16, 17 16 TH01 6, 9.3 9.3 8, 9.3 8, 9 7, 9.3 D13S317 12 13 11 10, 12 13 D16S539 12, 13 9 11, 12 11, 13 12 D2S1338 23, 24 17, 25 24 16 21 D19S433 14 14 13 11, 12 11, 14 vWA 16, 18 17 14 17, 22 15 TPOX 8 8 8, 11 8, 9 8, 9 D18S51 16 13, 15 14, 17 15, 17 11, 16 D5S818 11 9, 10 11 10, 11 12 FGA 20 21, 23 23 18, 23 22, 23 - 2 - Table S2. Antibodies used in this study. Catalogue Target Vendor Clone Dilution ratio Application1) Number 1:1000 (WB) ADI-SPA- 1:50 (IHC) HSP70 Enzo C92F3A-5 WB, IHC, IF, IP 810-F 1:50 (IF) 1 :1000 (IP) ADI-SPA- HSP90 Enzo 9D2 1:1000 WB 840-F 1:1000 (WB) Oct4 Abcam ab19857 WB, IF 1:100 (IF) Nanog Cell Signaling 4903S D73G4 1:1000 WB Sox2 Abcam ab97959 1:1000 WB ADI-SRA- Hop Enzo DS14F5 1:1000 WB 1500-F HIF-1α BD 610958 54/HIF-1α 1:1000 WB pAkt (S473) Cell Signaling 4060S D9E 1:1000 WB Akt Cell Signaling 9272S 1:1000 WB pMEK Cell Signaling 9121S 1:1000 WB (S217/221) MEK Cell Signaling 9122S 1:1000
    [Show full text]
  • Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant
    molecules Review Sephadex® LH-20, Isolation, and Purification of Flavonoids from Plant Species: A Comprehensive Review Javad Mottaghipisheh 1,* and Marcello Iriti 2,* 1 Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary 2 Department of Agricultural and Environmental Sciences, Milan State University, via G. Celoria 2, 20133 Milan, Italy * Correspondence: [email protected] (J.M.); [email protected] (M.I.); Tel.: +36-60702756066 (J.M.); +39-0250316766 (M.I.) Academic Editor: Francesco Cacciola Received: 20 August 2020; Accepted: 8 September 2020; Published: 10 September 2020 Abstract: Flavonoids are considered one of the most diverse phenolic compounds possessing several valuable health benefits. The present study aimed at gathering all correlated reports, in which Sephadex® LH-20 (SLH) has been utilized as the final step to isolate or purify of flavonoid derivatives among all plant families. Overall, 189 flavonoids have been documented, while the majority were identified from the Asteraceae, Moraceae, and Poaceae families. Application of SLH has led to isolate 79 flavonols, 63 flavones, and 18 flavanones. Homoisoflavanoids, and proanthocyanidins have only been isolated from the Asparagaceae and Lauraceae families, respectively, while the Asteraceae was the richest in flavones possessing 22 derivatives. Six flavones, four flavonols, three homoisoflavonoids, one flavanone, a flavanol, and an isoflavanol have been isolated as the new secondary metabolites. This technique has been able to isolate quercetin from 19 plant species, along with its 31 derivatives. Pure methanol and in combination with water, chloroform, and dichloromethane have generally been used as eluents. This comprehensive review provides significant information regarding to remarkably use of SLH in isolation and purification of flavonoids from all the plant families; thus, it might be considered an appreciable guideline for further phytochemical investigation of these compounds.
    [Show full text]
  • Index to the NLM Classification 2011
    National Library of Medicine Classification 2011 Index Disease see Tyrosinemias 1-8 5,12-diHETE see Leukotriene B4 1,2-Benzopyrones see Coumarins 5,12-HETE see Leukotriene B4 1,2-Dibromoethane see Ethylene Dibromide 5-HT see Serotonin 1,8-Dihydroxy-9-anthrone see Anthralin 5-HT Antagonists see Serotonin Antagonists 1-Oxacephalosporin see Moxalactam 5-Hydroxytryptamine see Serotonin 1-Propanol 5-Hydroxytryptamine Antagonists see Serotonin Organic chemistry QD 305.A4 Antagonists Pharmacology QV 82 6-Mercaptopurine QV 269 1-Sar-8-Ala Angiotensin II see Saralasin 7S RNA see RNA, Small Nuclear 1-Sarcosine-8-Alanine Angiotensin II see Saralasin 8-Hydroxyquinoline see Oxyquinoline 13-cis-Retinoic Acid see Isotretinoin 8-Methoxypsoralen see Methoxsalen 15th Century History see History, 15th Century 8-Quinolinol see Oxyquinoline 16th Century History see History, 16th Century 17 beta-Estradiol see Estradiol 17-Ketosteroids WK 755 A 17-Oxosteroids see 17-Ketosteroids A Fibers see Nerve Fibers, Myelinated 17th Century History see History, 17th Century Aardvarks see Xenarthra 18th Century History see History, 18th Century Abate see Temefos 19th Century History see History, 19th Century Abattoirs WA 707 2',3'-Cyclic-Nucleotide Phosphodiesterases QU 136 Abbreviations 2,4-D see 2,4-Dichlorophenoxyacetic Acid Chemistry QD 7 2,4-Dichlorophenoxyacetic Acid General P 365-365.5 Organic chemistry QD 341.A2 Library symbols (U.S.) Z 881 2',5'-Oligoadenylate Polymerase see Medical W 13 2',5'-Oligoadenylate Synthetase By specialties (Form number 13 in any NLM
    [Show full text]
  • Medical Management of Lower Extremity Chronic Venous Disease
    Medical management of lower extremity chronic venous disease Authors: Patrick C Alguire, MD, FACP Barbara M Mathes, MD, FACP, FAAD Section Editors: John F Eidt, MD Joseph L Mills, Sr, MD Deputy Editor: Kathryn A Collins, MD, PhD, FACS Contributor Disclosures All topics are updated as new evidence becomes available and our peer review process is complete. Literature review current through: Jul 2020. | This topic last updated: Apr 22, 2020. INTRODUCTION Venous hypertension is associated with histologic and ultrastructural changes in the capillary and lymphatic microcirculation that produce important physiologic changes, which include capillary leak, fibrin deposition, erythrocyte and leukocyte sequestration, thrombocytosis, and inflammation. These processes impair oxygenation of the skin and subcutaneous tissues. The clinical manifestations of severe venous hypertension and tissue hypoxia are edema, hyperpigmentation, subcutaneous fibrosis, and ulcer formation. The medical management of chronic venous disease with and without ulceration is discussed here. The etiology, presentation, and pathophysiology of chronic venous disorders are discussed elsewhere: ●(See "Classification of lower extremity chronic venous disorders".) ●(See "Clinical manifestations of lower extremity chronic venous disease".) ●(See "Pathophysiology of chronic venous disease".) ●(See "Diagnostic evaluation of lower extremity chronic venous insufficiency".) OVERVIEW Treatment goals for patients with chronic venous disease include improvement of symptoms, reduction of edema, prevention and treatment of lipodermatosclerosis (picture 1), and healing of ulcers [1,2]. An algorithm for the medical management of venous insufficiency is based upon available data and published recommendations (algorithm 1) [3-5]. Lipodermatosclerosis Picture 1 Skin induration, redness, and hyperpigmentation involving the lower third of the leg in a patient with stasis dermatitis and lipodermatosclerosis.
    [Show full text]