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Genetic Analysis of the Major Tribes of Buner and Swabi Areas Through Dental Morphology and Dna Analysis
GENETIC ANALYSIS OF THE MAJOR TRIBES OF BUNER AND SWABI AREAS THROUGH DENTAL MORPHOLOGY AND DNA ANALYSIS MUHAMMAD TARIQ DEPARTMENT OF GENETICS HAZARA UNIVERSITY MANSEHRA 2017 I HAZARA UNIVERSITY MANSEHRA Department of Genetics GENETIC ANALYSIS OF THE MAJOR TRIBES OF BUNER AND SWABI AREAS THROUGH DENTAL MORPHOLOGY AND DNA ANALYSIS By Muhammad Tariq This research study has been conducted and reported as partial fulfillment of the requirements of PhD degree in Genetics awarded by Hazara University Mansehra, Pakistan Mansehra The Friday 17, February 2017 I ABSTRACT This dissertation is part of the Higher Education Commission of Pakistan (HEC) funded project, “Enthnogenetic elaboration of KP through Dental Morphology and DNA analysis”. This study focused on five major ethnic groups (Gujars, Jadoons, Syeds, Tanolis, and Yousafzais) of Buner and Swabi Districts, Khyber Pakhtunkhwa Province, Pakistan, through investigations of variations in morphological traits of the permanent tooth crown, and by molecular anthropology based on mitochondrial and Y-chromosome DNA analyses. The frequencies of seven dental traits, of the Arizona State University Dental Anthropology System (ASUDAS) were scored as 17 tooth- trait combinations for each sample, encompassing a total sample size of 688 individuals. These data were compared to data collected in an identical fashion among samples of prehistoric inhabitants of the Indus Valley, southern Central Asia, and west-central peninsular India, as well as to samples of living members of ethnic groups from Abbottabad, Chitral, Haripur, and Mansehra Districts, Khyber Pakhtunkhwa and to samples of living members of ethnic groups residing in Gilgit-Baltistan. Similarities in dental trait frequencies were assessed with C.A.B. -
The Polymerase Chain Reaction (PCR): the Second Generation of DNA Analysis Methods Takes the Stand, 9 Santa Clara High Tech
Santa Clara High Technology Law Journal Volume 9 | Issue 1 Article 8 January 1993 The olP ymerase Chain Reaction (PCR): The Second Generation of DNA Analysis Methods Takes the Stand Kamrin T. MacKnight Follow this and additional works at: http://digitalcommons.law.scu.edu/chtlj Part of the Law Commons Recommended Citation Kamrin T. MacKnight, The Polymerase Chain Reaction (PCR): The Second Generation of DNA Analysis Methods Takes the Stand, 9 Santa Clara High Tech. L.J. 287 (1993). Available at: http://digitalcommons.law.scu.edu/chtlj/vol9/iss1/8 This Comment is brought to you for free and open access by the Journals at Santa Clara Law Digital Commons. It has been accepted for inclusion in Santa Clara High Technology Law Journal by an authorized administrator of Santa Clara Law Digital Commons. For more information, please contact [email protected]. THE POLYMERASE CHAIN REACTION (PCR): THE SECOND GENERATION OF DNA ANALYSIS METHODS TAKES THE STAND Kamrin T. MacKnightt TABLE OF CONTENTS INTRODUCTION ........................................... 288 BASIC GENETICS AND DNA REPLICATION ................. 289 FORENSIC DNA ANALYSIS ................................ 292 Direct Sequencing ....................................... 293 Restriction FragmentLength Polymorphism (RFLP) ...... 294 Introduction .......................................... 294 Technology ........................................... 296 Polymerase Chain Reaction (PCR) ....................... 300 H istory ............................................... 300 Technology .......................................... -
Mittelalterliche Migrationen Als Gegenstand Der "Genetic History"
Jörg Feuchter Mittelalterliche Migrationen als Gegenstand der ‚Genetic History‘ Zusammenfassung Genetic History untersucht historische Fragen mit der Quelle DNA. Migrationen sind ihr Hauptgegenstand, woraus sich eine große Bedeutung für die Mediävistik ergibt. Doch bis vor kurzem waren Historiker nicht beteiligt. Der Beitrag gibt eine Definition der neuen Dis- ziplin (), untersucht die Rolle des Konzeptes Migration in der Populationsgenetik () und beschreibt den Stand der Migrationsforschung in der Mediävistik (). Anschließend gibt er einen kurzen Überblick über die von der Genetic History untersuchten Migrationsräu- me (), betrachtet exemplarisch zunächst eine Studie zur angelsächsischen Migration nach Britannien () und dann ein aktuelles Projekt, in dem erstmals ein Mediävist die Leitung innehat (). Der Beitrag endet mit einigen allgemeinen Beobachtungen und Postulaten (). Keywords: Genetik; DNA; Mittelalter; Angelsachsen; Langobarden; Völkerwanderung. Genetic History is the study of historical questions with DNA as a source. Migrations are its main subject. It is thus very relevant to Medieval Studies. Yet until recently historians have not been involved. The contribution provides a definition of the new discipline (), explores the role of migration as a concept in Population Genetics () and describes the state of migration studies in Medieval History (). It then sets out for an overview of medieval migratory areas studied by Genetic History () and takes an exemplary look first () at a study on Anglo-Saxon migration to Britain and later () at a current project where for the first time a medieval historian has taken the lead. The contribution ends () with some general observations and stipulations. Keywords: Genetics; DNA; Middle Ages; Anglo-Saxons; Lombards; Migration Period. Danksagung: Der Verfasser dankt Prof. Dr. Veronika Lipphardt (University College Frei- burg) und der von ihr von bis geleiteten Nachwuchsgruppe Twentieth Century Felix Wiedemann, Kerstin P. -
HUMAN MITOCHONDRIAL DNA HAPLOGROUP J in EUROPE and NEAR EAST M.Sc
UNIVERSITY OF TARTU FACULTY OF BIOLOGY AND GEOGRAPHY, INSTITUTE OF MOLECULAR AND CELL BIOLOGY, DEPARTMENT OF EVOLUTIONARY BIOLOGY Piia Serk HUMAN MITOCHONDRIAL DNA HAPLOGROUP J IN EUROPE AND NEAR EAST M.Sc. Thesis Supervisors: Ph.D. Ene Metspalu, Prof. Richard Villems Tartu 2004 Table of contents Abbreviations .............................................................................................................................3 Definition of basic terms used in the thesis.........................................................................3 Introduction................................................................................................................................4 Literature overview ....................................................................................................................5 West–Eurasian mtDNA tree................................................................................................5 Fast mutation rate of mtDNA..............................................................................................9 Estimation of a coalescence time ......................................................................................10 Topology of mtDNA haplogroup J....................................................................................12 Geographic spread of mtDNA haplogroup J.....................................................................20 The aim of the present study ....................................................................................................22 -
Ancient Mitochondrial DNA from Pre-Historic
Grand Valley State University ScholarWorks@GVSU Masters Theses Graduate Research and Creative Practice 4-30-2011 Ancient Mitochondrial DNA From Pre-historic Southeastern Europe: The rP esence of East Eurasian Haplogroups Provides Evidence of Interactions with South Siberians Across the Central Asian Steppe Belt Jeremy R. Newton Grand Valley State University Follow this and additional works at: http://scholarworks.gvsu.edu/theses Part of the Cell Biology Commons, and the Molecular Biology Commons Recommended Citation Newton, Jeremy R., "Ancient Mitochondrial DNA From Pre-historic Southeastern Europe: The rP esence of East Eurasian Haplogroups Provides Evidence of Interactions with South Siberians Across the Central Asian Steppe Belt" (2011). Masters Theses. 5. http://scholarworks.gvsu.edu/theses/5 This Thesis is brought to you for free and open access by the Graduate Research and Creative Practice at ScholarWorks@GVSU. It has been accepted for inclusion in Masters Theses by an authorized administrator of ScholarWorks@GVSU. For more information, please contact [email protected]. ANCIENT MITOCHONDRIAL DNA FROM PRE-HISTORIC SOUTH- EASTERN EUROPE: THE PRESENCE OF EAST EURASIAN HAPLOGROUPS PROVIDES EVIDENCE OF INTERACTIONS WITH SOUTH SIBERIANS ACROSS THE CENTRAL ASIAN STEPPE BELT A thesis submittal in partial fulfillment of the requirements for the degree of Master of Science By Jeremy R. Newton To Cell and Molecular Biology Department Grand Valley State University Allendale, MI April, 2011 “Not all those who wander are lost.” J.R.R. Tolkien iii ACKNOWLEDGEMENTS I would like to extend my sincerest thanks to every person who has motivated, directed, and encouraged me throughout this thesis project. I especially thank my graduate advisor, Dr. -
Final Programme
Ancient DNA: applications in human evolutionary history Organised by Professor Erika Hagelberg, Professor Michael Hofreiter and Professor Christine Keyser Wednesday 20 - Thursday 21 November 2013 DAY 1 DAY 2 SESSION 1 SESSION 2 SESSION 3 SESSION 4 Human migration Chair Erika Hagelberg Historical transformations Technical issues Human evolution debates 09.00 Welcome by Royal Society Chair Anders Götherström Chair Michael Hofreiter Chair Paul Mellars & lead organiser Agnar Helgason Paula Campos Eva-Maria Geigl Carles Lalueza-Fox Assessing the authenticity of Pleistocene humans in the Palaeogenomic analysis of Paleogenomics and the 09.05 13.30 clonal sequence reads from 09.00 13.30 Americans/East Asia and their ancient humans: Mesolithic-Neolithic transition ancient samples: a case study environment methodological issues in Europe from Iceland 09.30 Discussion 14.00 Discussion 09.30 Discussion 14.00 Discussion Pontus Skoglund David Reich Anne Stone Genomic analysis of prehistoric Erika Hagelberg The landscape of Neandertal 09.45 Impacts of colonization in the 14.15 populations in Europe: 09.45 Shall we still worry about 14.15 ancestry in present-day humans Americas authentication and population contamination? history 10.15 Discussion 14.45 Discussion 10.15 Discussion 14.45 Discussion 10.30 Coffee 15.00 Tea 10.30 Coffee 15.00 Tea Marie-France Deguilloux Concepción de la Rua Odille Loreille Where are the Caribs? Ancient The Neolithic transition in the Elena Gigli Next generation sequencing 11.00 DNA from ceramic period 15.30 Cantabrian fringe -
Profile of Alec J. Jeffreys
Profile of Alec J. Jeffreys s one of the great contributors to modern genetics, Sir Alec Jeffreys was born with curiosity in his genes as the son and Agrandson of prolific inventors. Jeffreys displayed an insatiable quest for knowl- edge, and his father fostered his son’s budding scientific interests with gifts of a microscope and chemistry set, the latter of which produced one of Jeffreys’ most memorable scientific ventures. ‘‘Those were back in the happy days of chemis- try,’’ Jeffreys points out, ‘‘where you could go down to your local pharmacist and get virtually everything you wanted.’’ The end result of that chemistry experiment was the detonation of his aunt’s apple tree and a set of scars that Jeffreys still bears to- day. ‘‘You learn science very fast that way,’’ he says, ‘‘but it was quite fun.’’ Jeffreys’ scientific curiosity only in- creased after the apple tree incident, and years later it would lead to one of the Alec J. Jeffreys most widely used applications in genetics: DNA fingerprinting. Among other uses, the DNA fingerprinting technique has freys go there, so Jeffreys entered the turn led to another groundbreaking find- helped solve numerous criminal investi- university in 1968. He was at first intent ing about the composition of eukaryotic gations, settle countless paternity dis- on pursuing a degree in biochemistry DNA: introns (3). ‘‘I was 27 at the time, putes, and spark a resurgence of interest but soon decided to alter his course. so still a real rookie, with the ability to in the forensic sciences. That achieve- ‘‘This was no criticism of the way it was detect single-copy DNA by Southern blot ment alone is worthy of merit, contrib- taught,’’ he says of biochemistry at Ox- hybridization and a nice paper on introns uting to Jeffreys’ receiving three high ford, ‘‘but rather a reflection of the fac- under my belt, which is, yeah, not a bad distinctions in 2005: the Albert Lasker ulty’s research, which leaned heavily to start,’’ he says. -
Most of the Extant Mtdna Boundaries in South and Southwest Asia Were
BMC Genetics BioMed Central Research article Open Access Most of the extant mtDNA boundaries in South and Southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans Mait Metspalu*1, Toomas Kivisild1, Ene Metspalu1, Jüri Parik1, Georgi Hudjashov1, Katrin Kaldma1, Piia Serk1, Monika Karmin1, DoronMBehar2, M Thomas P Gilbert6, Phillip Endicott7, Sarabjit Mastana4, Surinder S Papiha5, Karl Skorecki2, Antonio Torroni3 and Richard Villems1 Address: 1Institute of Molecular and Cell Biology, Tartu University, Tartu, Estonia, 2Bruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel, 3Dipartimento di Genetica e Microbiologia, Università di Pavia, Pavia, Italy, 4Department of Human Sciences, Loughborough University, Loughborough, United Kingdom, 5Department of Human Genetics, University of Newcastle-upon- Tyne, United Kingdom, 6Ecology and Evolutionary Biology, The University of Arizona, Tucson, Arizona, USA and 7Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford OX1 3PS,United Kingdom Email: Mait Metspalu* - [email protected]; Toomas Kivisild - [email protected]; Ene Metspalu - [email protected]; Jüri Parik - [email protected]; Georgi Hudjashov - [email protected]; Katrin Kaldma - [email protected]; Piia Serk - [email protected]; Monika Karmin - [email protected]; Doron M Behar - [email protected]; M Thomas P Gilbert - [email protected]; Phillip Endicott - [email protected]; Sarabjit Mastana - [email protected]; Surinder S Papiha - [email protected]; Karl Skorecki - [email protected]; Antonio Torroni - [email protected]; Richard Villems - [email protected] * Corresponding author Published: 31 August 2004 Received: 07 May 2004 Accepted: 31 August 2004 BMC Genetics 2004, 5:26 doi:10.1186/1471-2156-5-26 This article is available from: http://www.biomedcentral.com/1471-2156/5/26 © 2004 Metspalu et al; licensee BioMed Central Ltd. -
The DNA Fingerprinting Story Mark a Jobling
Jobling Investigative Genetics 2013, 4:20 http://www.investigativegenetics.com/content/4/1/20 OPINION Open Access Curiosity in the genes: the DNA fingerprinting story Mark A Jobling It is unusual for a scientific field to be associated with a The first DNA fingerprinting application was in par- single individual, but in the case of the subject of the the- entage testing [6]; normally it is the father who is in matic series now being launched in Investigative Genetics, doubt, but this unusual and challenging case was a ma- this is surely so; Alec Jeffreys (Figure 1) is DNA finger- ternity test, with paternal DNA unavailable. British nurse printing. Having invented the method, he coined the per- Christiana Sarbah’s 13-year-old son Andrew was denied fect name for it - how different things might have been if re-entry to the United Kingdom after a visit to Ghana, it had been called the tandem-repeat-based identification the immigration authorities suspecting that he was not technique (or something similarly dull). He realized its her child. Given three undisputed children for comparison, potential and immediately applied, developed and refined it was possible to reconstruct the absent father’sDNA it. He then followed his nose to unravel the mystery of fingerprint, and to strongly support the claimed maternity the madly mutable minisatellites that make up DNA over alternative relationships such as aunt-nephew - some- fingerprints, and eventually to understand the engines of thing that was not achieved with traditional protein poly- genome variability that reside in recombination hotspots. morphisms such as blood groups. -
Mitochondrial Variability in the Mediterranean Area: a Complex Stage for Human Migrations
UC Irvine UC Irvine Previously Published Works Title Mitochondrial variability in the Mediterranean area: a complex stage for human migrations. Permalink https://escholarship.org/uc/item/4p72d0rd Journal Annals of human biology, 45(1) ISSN 0301-4460 Authors De Angelis, Flavio Scorrano, Gabriele Martínez-Labarga, Cristina et al. Publication Date 2018-02-01 DOI 10.1080/03014460.2017.1416172 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Annals of Human Biology ISSN: 0301-4460 (Print) 1464-5033 (Online) Journal homepage: http://www.tandfonline.com/loi/iahb20 Mitochondrial variability in the Mediterranean area: a complex stage for human migrations Flavio De Angelis, Gabriele Scorrano, Cristina Martínez-Labarga, Giuseppina Scano, Fabio Macciardi & Olga Rickards To cite this article: Flavio De Angelis, Gabriele Scorrano, Cristina Martínez-Labarga, Giuseppina Scano, Fabio Macciardi & Olga Rickards (2018) Mitochondrial variability in the Mediterranean area: a complex stage for human migrations, Annals of Human Biology, 45:1, 5-19, DOI: 10.1080/03014460.2017.1416172 To link to this article: https://doi.org/10.1080/03014460.2017.1416172 View supplementary material Published online: 30 Jan 2018. Submit your article to this journal View related articles View Crossmark data Citing articles: 1 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=iahb20 ANNALS OF HUMAN BIOLOGY, 2018 VOL. 45, NO. 1, 5–19 https://doi.org/10.1080/03014460.2017.1416172 -
Mitochondrial DNA in Ancient Human Populations of Europe
Mitochondrial DNA in Ancient Human Populations of Europe Clio Der Sarkissian Australian Centre for Ancient DNA Ecology and Evolutionary Biology School of Earth and Environmental Sciences The University of Adelaide South Australia A thesis submitted for the degree of Doctor of Philosophy at The University of Adelaide July 2011 TABLE OF CONTENTS Abstract .................................................................................................... 10 Thesis declaration .................................................................................... 11 Acknowledgments ................................................................................... 12 General Introduction .............................................................................. 14 RECONSTRUCTING PAST HUMAN POPULATION HISTORY USING MODERN MITOCHONDRIAL DNA .................................................................... 15 Mitochondrial DNA: presentation ........................................................................ 15 Studying mitochondrial variation ......................................................................... 16 Genetic variation ........................................................................................ 16 Phylogenetics and phylogeography ........................................................... 16 Dating using molecular data, and its limits ............................................... 17 Population genetics .................................................................................... 19 The coalescent -
Past Human Migrations in East Asia: Matching Archaeology, Linguistics
16 A genetic perspective on the origins and dispersal of the Austronesians Mitochondrial DNA variation from Madagascar to Easter Island Erika Hagelberg, Murray Cox, Wulf Schiefenhövel, and Ian Frame Introduction This chapter describes the study of one genetic system, mitochondrial DNA (mtDNA), within the Austronesian-speaking world, and discusses whether the patterns of genetic variation at this genetic locus are consistent with the principal models of the settlement and linguistic diversity in this vast geographical region. Mitochondria are the seat of cellular metabolism and have their own complement of DNA. MtDNA is a tiny proportion of the genetic makeup of a human being, and has both advantages and disadvantages in population studies. It is inherited maternally, in contrast with the nuclear chromosomal DNA inherited from both parents. (Note: the mitochondria of the spermatozoon are eliminated from the egg soon after fertilization, so offspring do not inherit paternal mtDNA, although there are exceptions to this rule, as shown by Schwartz and Vissing 2002.) The maternal mode of inheritance permits the study of female lineages through time. Despite the small size of the mitochondrial genome, each mitochondrion has many thousands of copies of mtDNA, and there are many mitochondria in each cell. The abundance of mtDNA in cells has been exploited in anthropological research on ancient, rare or degraded biological samples, including archaeological bones, old hair samples, or dried blood (Hagelberg 1994). MtDNA accumulates mutations at a relatively fast rate, and so is useful for the investigation of recent evolutionary events. These features have made mtDNA an excellent marker for geneticists interested in human evolutionary history (see Wallace 1995 for review).