Supplementary Data – Table S2. Sixty-nine whose changed expression after treatment with ES-285 was found to be dose-responsive in both blood samples and skin biopsies.

Entries with no common name or description represent transcripts of unknown function.

Blood Skin Array Spot Common Gene Description P value P value Number Name 0.000 0.000 771295 0.000 0.037 127928 0.000 0.049 83129 GGCX Gamma-glutamyl carboxylase 0.001 0.006 1640691 0.001 0.000 34481 DEAF1 Deformed epidermal autoregulatory factor 1 0.002 0.019 859586 CDC42 Cell division cycle 42 0.002 0.038 203347 CLTC Clathrin, heavy polypeptide (Hc) 0.003 0.020 839374 EXTL2 Exostoses (multiple)-like 2 0.003 0.009 1644472 0.004 0.005 280262 TNFRSF21 TNF receptor superfamily, member 21 0.005 0.004 1636281 0.005 0.000 814975 WDR9 21 107 0.005 0.028 136064 MGC16169 Hypothetical MGC16169 0.006 0.001 276496 0.007 0.043 276574 FLJ36754 Hypothetical protein FLJ36754 0.008 0.000 342721 ITGB2 Integrin, beta 2 (CD18; LFA antigen 1) 0.008 0.042 681917 IL1RAP Interleukin 1 receptor accessory protein 0.008 0.050 127193 Hypothetical gene supported by BX647146 0.008 0.012 200813 UBE2V1 Ubiquitin-conjugating E2 variant 1 0.009 0.040 1604281 C21ORF5 Chromosome 21 open reading frame 5 0.010 0.031 296190 ZFYVE26 , FYVE domain containing 26 0.010 0.018 743230 TNCRNA Trophoblast-derived noncoding RNA 0.011 0.019 1708366 PDCD4 Programmed cell death 4 0.011 0.048 1752379 LIG3 III, DNA, ATP-dependent 0.011 0.000 43070 0.012 0.020 1470060 TUBA3 Tubulin, alpha 3 0.012 0.007 758491 OSBPL8 Oxysterol binding protein-like 8 0.012 0.042 233323 TMEM23 Transmembrane protein 23 0.012 0.008 195138 LPGAT1 Family with sequence similarity 34, member A 0.013 0.005 141726 0.013 0.003 242963 CDNA FLJ40173 fis, clone TESTI2016922 0.014 0.021 213575 0.014 0.003 123788 Transcribed 0.015 0.004 245067 NP Nucleoside phosphorylase 0.015 0.006 41750 NFE2L2 Transcribed locus 0.016 0.014 134995 ZBTB33 Zinc finger and BTB domain containing 33 0.018 0.005 289570 NSMAF Neutral sphingomyelinase (N-SMase) activation associated factor 0.018 0.024 450661 PPIL2 Peptidylprolyl (cyclophilin)-like 2 0.018 0.012 258991 ZFP42 Zinc finger protein 42 0.019 0.006 211940 DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.019 0.003 154379 LOC284465 Hypothetical protein LOC284465

0.023 0.037 773215 RUNX1 Runt-related transcription factor 1 (aml1 0.024 0.012 121687 CD48 CD48 antigen (B-cell membrane protein) 0.025 0.002 142468 USP53 Ubiquitin specific protease 53 0.025 0.000 795777 KIAA1466 KIAA1466 protein 0.026 0.007 741701 MRPL49 Mitochondrial ribosomal protein L49 0.027 0.017 206722 C9ORF80 open reading frame 80 0.027 0.006 429561 COL14A1 collagen, type XIV, alpha 1 (undulin) 0.028 0.000 139365 RNF138 Ring finger protein 138 0.029 0.017 738900 MUF1 MUF1 protein 0.029 0.000 45600 MVK Mevalonate Kinase (mevalonic aciduria) 0.030 0.001 273257 0.031 0.019 768299 KIAA0924 KIAA0924 protein 0.032 0.000 742711 0.032 0.000 814744 0.033 0.001 730859 CENTB2 Centaurin, beta 2 0.034 0.000 41731 AP1GBP1 AP1 gamma subunit binding protein 1 0.034 0.017 814014 ZNF184 Zinc finger protein 184 (Kruppel-like) 0.035 0.018 815501 LMNB2 Lamin B2 0.036 0.037 21515 SLC4A3 Solute carrier family 4, anion exchanger, # 3 0.038 0.014 203300 LOC284058 Hypothetical protein LOC284058 0.040 0.002 785907 FNBP1 Formin binding protein 1 0.041 0.034 769562 MCM4 minichromosome maintenance deficient 4 0.042 0.032 343180 MGC40499 Hypothetical protein MGC40499 0.044 0.046 140252 Transcribed locus 0.045 0.046 729881 DDHD1 DDHD domain containing 1 0.047 0.000 266227 0.047 0.000 80374 PDHA1 Pyruvate dehydrogenase (lipoamide) alpha 1 0.048 0.017 343987 DPP4 Dipeptidylpeptidase 4