Anti-SELS (Aa 71-120) Polyclonal Antibody (CABT- BL5610) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-SELS (aa 71-120) polyclonal antibody (CABT- BL5610) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit polyclonal antibody to Human SELS.

Antigen Description This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3 UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Immunogen Synthetic peptide designed within residues: PDVVVKRQEA LAAARLKMQE ELNAQVEKHK EKLKQLEEEK RRQKIEMWDS, corresponding to internal sequence amino acids 71-120 of Human SELS.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Cellular Localization Endoplasmic reticulum; endoplasmic reticulum membrane; single pass membrane protein.

Format Liquid

Size 50 μg

Buffer 2% Sucrose, PBS

Preservative None

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Introduction This gene encodes a member of the selenoprotein family, characterized by a selenocysteine (Sec) residue at the active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3 UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GENE INFORMATION

Entrez Gene ID 55829

Protein Refseq NP_060915

UniProt ID Q9BQE4

Pathway HRD1/SEL1 ERAD complex, organism-specific biosystem; HRD1/SEL1 ERAD complex, conserved biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem; Selenium Metabolism and Selenoproteins, organism-specific biosystem; Selenium Pathway, organism-specific biosystem;

Function antioxidant activity; enzyme binding; protein binding; receptor activity; selenium binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]