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An Introduction to the CDC Public Health Genomics Knowledge Base
Division of Public Health Information Dissemination Center for Surveillance, Epidemiology, and Laboratory Services An Introduction to the CDC Public Health Genomics Knowledge Base Marta Gwinn, Dave Dotson, Wei Yu & Ridgely Fisk Green Office of Public Health Genomics Division of Public Health Information Dissemination CDC Office of Public Health Genomics (OPHG) Effective and responsible translation of genome-based discoveries into disease prevention and population health https://www.cdc.gov/genomics 1. Identify 2. Inform 3. Integrate evidence-based applications and communicate into practice & programs OPHG, DPHID, CSELS CDC Information Database Why did we build it? . Challenge: Finding information about genomics- and family health history-related activities at CDC . Opportunity: Provide a centralized, searchable, publicly available database for CDC resources related to genomics and family health history CDC-Authored Genomics Publications Database Why did we build it? . Challenge: Finding CDC-authored publications on genomics and family health history . Opportunity: Provide a centralized, searchable, publicly available database for these CDC publications . Challenge: CDC’s work in genomics and family health history is not well known . Opportunity: Showcase CDC publications to highlight work related to genomics and family health history CDC-Authored Genomic Publications Database continued . Scientific articles and reports with at least one CDC author . CDC Science Clips: https://www.cdc.gov/library/sciclips/ . PubMed . Scopus affiliation search . Author notifications Genomics and Health Impact Scan Database Why did we build it? . Challenge: Keeping up with the latest developments in genomics and family health history relevant to public health . Opportunity: Identify the latest publications and other resources on population-based applications of genomic discoveries . -
Introduction to Nutrigenetics, Nutrigenomics and Epigenetics
Medicine, Nursing and Health Sciences Introduction to Nutrigenetics, Nutrigenomics and Epigenetics Australia n China n India n Italy n Malaysia n South Africa Introduction to Nutrigenetics, Nutrigenomics and Epigenetics The Nutrition Society of Australia (Melbourne), Monash University and MyGene are pleased to invite you to our upcoming ‘Introduction to Nutrigenetics, Nutrigenomics and Epigenetics’ symposium. Please note, numbers will be capped at 100, and delegates need to sign up for their preferred workshop sessions using the link below. Where: Level 5 of The Alfred Centre, Monash University (Go to the 1.00pm Networking coffee/tea Foyer of Lecture Theatre ‘B’ set of lifts in the The Alfred Centre), 99 Commercial Road, 1.30pm Introduction to Nutrigenetics, Michael Fenech (CSIRO) Melbourne. Nutrigenomics and Epigenetics Jeff Craig (MCRI) When: 1-5.15pm, 2.30pm Global trends in genetics: research, Graeme Smith (MyGene) Tuesday 27 August 2013 technology and practice Melissa Adamski (MyGene) RSVP: Brianna McFarlane, [email protected] 3.10pm Tea/coffee break Foyer of Lecture Theatre (by 13 August 2013) 3.30pm Workshop 1 Level 5 breakout room The workshops are a choice of two 4.15pm Changeover time from following topics (click link below to sign up): 4.30pm Workshop 2 Level 5 breakout room Workshop preference: 5.15pm Close http://www.mygene.com.au/nsa- symposium/ 1. Designing genetic research projects (including considering the data, Biographies In 2003-05, Dr Fenech proposed a novel interpreting the data and validation) disease prevention strategy based on Michael Fenech 2. Adding genetic testing to your personalised diagnosis and prevention of current research project Professor Michael Fenech is recognised DNA damage by appropriate diet/life-style internationally for his research in nutritional intervention, which has led to the Genome 3. -
DRAFT INTRODUCTION. Please Do Not Use Without Permission 1
DRAFT INTRODUCTION. Please do not use without permission Genomics and Genetic Medicine: Pathways to Global Health? This special issue of Anthropology and Medicine contributes to emerging anthropological research examining the expanding terrain of genomic research and genetic medicine as a product of and vector for globalisation (Beaudevin and Pordie 2016) and the ways it is being aligned with ‘Global Health’ (Koplan et al 2009). It builds on a growing body of literature in anthropology that observes how this arena of science and medicine is unfolding across a range of national and transnational contexts with uneven and often inequitable consequences (Whitmarsh 2008, Fullwiley 2011, Sleeboom-Faulkner 2010, Wade et al 2014, Taussig and Gibbon 2014). The papers presented here explore comparatively and transnationally the complex and somewhat paradoxical interface between genomics and/or genetic medicine and the emerging landscape of ‘Global Health’. It is important to note that the meeting point between these domains is not new, with the WHO consistently highlighting the relevance of genetics to addressing human health since the 1950s. 1 Nevertheless, the recent expansion of genomics as a global and globalising research terrain marks a particular moment in the way that a domain of genetic knowledge and technology is being used to address a range of health care challenges. This now encompasses not only ‘rare’ disease but also the growing rates of non-communicable chronic disease in low- and middle-income countries, as well as infectious disease, with genetics becoming tied to large transnational epidemiological studies to address epidemics such as Malaria (see Achidi et al 2008). -
6615 Sofiva Genomics
6615 SOFIVA GENOMICS Chairman Yi-Ning Su 2017.01.04 Company Profile SOFIVA GENOMICS Founded in July, 2012, SOFIVA GENOMICS focuses on clinical needs to develop next-generation testing models in genomic medicine Maternal-Fetal Medicine Genomic Medicine Clinical Medicine We have Asia’s leading genetic testing laboratory to provide comprehensive services to those in need Our Orientation ■ Mothers and fetuses Targets ■ Individuals with genetic diseases ■ Individuals with cancer ■ Healthy individuals ■ Mothers and fetuses: Helping mothers successfully conceive and safely give birth to healthy babies ■ Individuals with genetic diseases: Helping doctors in giving patients swift and accurate diagnoses and treatments Service Orientation ■ Individuals with cancer: Facilitating the detection, prognosis, and tracking of cancer so that doctors can treat and monitor their patients more accurately ■ Healthy individuals: Grasping their genetic health and risk of contracting disease and early planning for health promotion ■ Now: Technology and platform combining biochemical detection + gene chip Technical + next-generation sequencing to provide customers with comprehensive Development testing services ■Future: Development of comprehensive and customized testing using a single sample and a single platform ■ Business promotion: Joint promotion and hospitals, introduction to medical personnel, onsite recommendations, promotion at foreign Marketing and domestic conferences/expos Channels ■ PR promotion: online/Facebook marketing, literature and posters to -
Biostatistics and Bioinformatics
BIOSTATISTICS AND phd-health-and-biomedical-data-science-applied- biostatistics-concentration/) BIOINFORMATICS The Department of Biostatistics and Bioinformatics strives to *The MS and PhD programs in biostatistics are administered improve public health through excellence in education and jointly by the Department of Statistics in the Columbian College teaching in biostatistics and bioinformatics, transformative of Arts and Sciences (CCAS) and the Department of Biostatistics scientific research, and dedicated service to the university, and Bioinformatics in the Milken Institute School of Public profession and community. With Department faculty that have Health. The degrees are conferred by CCAS. received more research funding than any other department at the university, the Department educates the next generation The MS and PhD programs in health and biomedical data of leaders in biostatistics and bioinformatics by providing science are administered solely by the Department of opportunities for close interactions with award winning faculty Biostatistics and Bioinformatics in the Milken Institute School of and practical real-world training opportunities in clinical trials, Public Health. observational studies, diagnostic studies, and bioinformatics and computational biology studies. FACULTY Professors: K.A. Crandall, G. Diao, S.R. Evans (Chair), T. UNDERGRADUATE Hamasaki (Research), H.J. Hoffman, J.M. Lachin (Research), Y. Minor program Ma, S.J. Simmens (Research), E.A. Thom (Research) • Minor in bioinformatics (http://bulletin.gwu.edu/public- Associate Professors: I. Bebu (Research), K.L. health/biostatistics-bioinformatics/minor-bioinformatics/) Drews (Research), A. Elmi, M. Perez-Losada, M.G. Temprosa (Research), N. Younes (Research) GRADUATE Assistant Professors: N.M. Butera (Research), A. Ciarleglio, A. Master's programs Ghosh (Research), Y. -
Genomics in Public Health: Perspective from the Office of Public Health Genomics at the Centers for Disease Control and Prevention (CDC)
Healthcare 2015, 3, 830-837; doi:10.3390/healthcare3030830 OPEN ACCESS healthcare ISSN 2227-9032 www.mdpi.com/journal/healthcare Review Genomics in Public Health: Perspective from the Office of Public Health Genomics at the Centers for Disease Control and Prevention (CDC) Ridgely Fisk Green 1,*, W. David Dotson 2, Scott Bowen 2, Katherine Kolor 2 and Muin J. Khoury 2 1 Carter Consulting, Inc. and Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA 2 Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; E-Mails: [email protected] (W.D.D.); [email protected] (S.B.); [email protected] (K.K.); [email protected] (M.J.K.) * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +1-404-498-3884; Fax: +1-404-498-0140. Academic Editors: Cecelia A. Bellcross and Debra Duquette Received: 31 July 2015 / Accepted: 8 September 2015 / Published: 15 September 2015 Abstract: The national effort to use genomic knowledge to save lives is gaining momentum, as illustrated by the inclusion of genomics in key public health initiatives, including Healthy People 2020, and the recent launch of the precision medicine initiative. The Office of Public Health Genomics (OPHG) at the Centers for Disease Control and Prevention (CDC) partners with state public health departments and others to advance the translation of genome-based discoveries into disease prevention and population health. To do this, OPHG has adopted an “identify, inform, and integrate” model: identify evidence-based genomic applications ready for implementation, inform stakeholders about these applications, and integrate these applications into public health at the local, state, and national level. -
A Murine Atlas of Age-Related Changes in Intercellular Communication Inferred with the Package Scdiffcom
bioRxiv preprint doi: https://doi.org/10.1101/2021.08.13.456238; this version posted August 15, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. scAgeCom: a murine atlas of age-related changes in intercellular communication inferred with the package scDiffCom Cyril Lagger 1,*, Eugen Ursu 2,*, Anaïs Equey 3, Roberto A. Avelar 1, Angela O. Pisco 4, Robi Tacutu 2, João Pedro de Magalhães 1,# 1. Integrative Genomics of Ageing Group, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK 2. Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania 3. Department of Medicine, Karolinska Institutet, Stockholm, Sweden 4. Chan Zuckerberg Biohub, San Francisco, California, USA *These authors contributed equally #Corresponding author’s email: [email protected] Abstract Dysregulation of intercellular communication is a well-established hallmark of aging. To better understand how this process contributes to the aging phenotype, we built scAgeCom, a comprehensive atlas presenting how cell-type to cell-type interactions vary with age in 23 mouse tissues. We first created an R package, scDiffCom, designed to perform differential intercellular communication analysis between two conditions of interest in any mouse or human single-cell RNA-seq dataset. The package relies on its own list of curated ligand-receptor interactions compiled from seven established studies. We applied this tool to single-cell transcriptomics data from the Tabula Muris Senis consortium and the Calico murine aging cell atlas. -
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VOLUME 2: NO. 2 APRIL 2005 TOOLS AND TECHNIQUES Genomics and Public Health: Development of Web-based Training Tools for Increasing Genomic Awareness Jennifer Bodzin, MPH, Sharon L.R. Kardia, PhD, Aaron Goldenberg, MA, MPH, Sarah F. Raup, MPH, Janice V. Bach, MS, Toby Citrin, JD Suggested citation for this article: Bodzin J, Kardia SLR, Introduction Goldenberg A, Raup SF, Bach JV, Citrin T. Genomics and public health: development of Web-based training tools for As genomics research continues to expand and identify increasing genomic awareness. Prev Chronic Dis [serial potential applications for disease prevention, departments online] 2005 Apr [date cited]. Available from: URL: of health as well as public health practitioners will need to http://www.cdc.gov/pcd/issues/2005/apr/04_0133.htm. become increasingly aware of genomics as a public health tool. In 2001, the Centers for Disease Control and Prevention (CDC) produced a set of competencies to help Abstract integrate genomics into public health practice and training (1,2). Genomic competencies were developed for all mem- In 2001, the Centers for Disease Control and bers of the public health workforce, along with specific Prevention funded three Centers for Genomics and competencies for each functional area of public health: Public Health to develop training tools for increasing administration, clinical, epidemiology, health education, genomic awareness. Over the past three years, the cen- laboratory, and environmental health (3). These compe- ters, working together with the Centers for Disease tencies are described in detail and are available from Control and Prevention’s Office of Genomics and Disease www.cdc.gov/genomics/training/competencies/comps.htm Prevention, have developed tools to increase awareness (4). -
Genomics on Public Health Course
The impact of Genomics on public health course Why is this course necessary? Layla Jader Contents • Definitions • History of this field • The genomic impact on public health actions • The main determinants of health • Epigenetics • Final messages • “genetics” is the study of single genes & their effects • “genomics” is the study not just of single genes, but of the complete genetic material of an organism • also covers the development of genome- scale technologies and their application to ALL areas of biological investigations. Public Health Genomics (PHG) became a new public health field in 1997 “It is the responsible & effective integration of genome-based knowledge & technologies into public policy & health services for the benefit of population health” It combines & integrates insights from knowledge from population sciences genetic & & the humanities & molecular science social sciences to develop programmes & policies aimed at protecting & improving the health of the population National Office of Public Health phgfoundation Genomics 1997 1997 2005 2006 2010 2005 WHO-Collaborating Centre on Public Health Genomics So, what are the implications of genomics to Public Health? “Genomics is to the 21st century what infectious diseases were to the 20th century” Genomics is impacting the main pillars of public health Public health actions The impact of genomics 1. Health protection & . More accurate & quicker resilience diagnosis . Communicable diseases .Identifying new virulent variants . Tracking disease outbreaks . Identifying those more susceptible to infectious diseases leading to family clusters Public health The impact of genomics actions 1. Health . Biosensors to monitor protection & pollutants resilience . Biorobots to protect against • Environmental biological & chemical warfare health . Environmental clean up & land bioremediation using microbes to detoxify or remove pollutants . -
Circulating Exosomes Potentiate Tumor Malignant Properties in a Mouse Model of Chronic Sleep Fragmentation
www.impactjournals.com/oncotarget/ Oncotarget, Vol. 7, No. 34 Research Paper Circulating exosomes potentiate tumor malignant properties in a mouse model of chronic sleep fragmentation Abdelnaby Khalyfa1, Isaac Almendros1,4, Alex Gileles-Hillel1, Mahzad Akbarpour1, Wojciech Trzepizur1, Babak Mokhlesi2, Lei Huang3, Jorge Andrade3, Ramon Farré4, David Gozal1 1Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA 2Department of Medicine, Section of Pulmonary and Critical Care, Sleep Disorders Center, The University of Chicago, Chicago, IL, USA 3Center for Research Informatics, The University of Chicago, Chicago, IL, USA 4Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona-Institut Investigacions Biomediques August Pi Sunyer-CIBER Enfermedades Respiratorias, Barcelona, Spain Correspondence to: David Gozal, email: [email protected] Keywords: sleep fragmentation, obstructive sleep apnea, tumors, microenvironment, cancer biology Received: April 16, 2016 Accepted: June 30, 2016 Published: July 13, 2016 ABSTRACT Background: Chronic sleep fragmentation (SF) increases cancer aggressiveness in mice. Exosomes exhibit pleiotropic biological functions, including immune regulatory functions, antigen presentation, intracellular communication and inter- cellular transfer of RNA and proteins. We hypothesized that SF-induced alterations in biosynthesis and cargo of plasma exosomes may affect tumor cell properties. Results: SF-derived exosomes increased tumor cell proliferation (~13%), migration (~2.3-fold) and extravasation (~10%) when compared to exosomes from SC-exposed mice. Similarly, Pre exosomes from OSA patients significantly enhanced proliferation and migration of human adenocarcinoma cells compared to Post. SF- exosomal cargo revealed 3 discrete differentially expressed miRNAs, and exploration of potential mRNA targets in TC1 tumor cells uncovered 132 differentially expressed genes that encode for multiple cancer-related pathways. -
The 2010 State Public Health Genomics Resource Guide Table of Contents
The 2010 State Public Health Genomics Resource Guide Table of Contents Section 1 Overview of Public Health Genomics Today ......................................................................................... 6 Section 2 Promising Practices ............................................................................................................................ 14 Public Health Function: Assessment ................................................................................................................ 17 Public Health Function: Policy Development .................................................................................................... 24 Public Health Function: Assurance .................................................................................................................. 55 Section 3 Charting a Path for Genomics in Your State ....................................................................................... 67 Step 1: Obtaining Agency Support and Buy-In ................................................................................................ 70 Step 2: Taking Stock ....................................................................................................................................... 71 Step 3: Charting A Course .............................................................................................................................. 72 Step 4: Taking Action .................................................................................................................................... -
Lifelong Restriction of Dietary Branched-Chain Amino Acids Has Sex-Specific Benefits for Frailty and Life Span in Mice
ARTICLES https://doi.org/10.1038/s43587-020-00006-2 Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice Nicole E. Richardson 1,2,3, Elizabeth N. Konon1,2, Haley S. Schuster1,2, Alexis T. Mitchell1,2, Colin Boyle1,2, Allison C. Rodgers1, Megan Finke1,2, Lexington R. Haider1,2, Deyang Yu1,2, Victoria Flores1,2,4, Heidi H. Pak1,2,4, Soha Ahmad1,2, Sareyah Ahmed1,2, Abigail Radcliff1,2, Jessica Wu1,2, Elizabeth M. Williams1,2, Lovina Abdi1,2, Dawn S. Sherman1,2, Timothy A. Hacker1 and Dudley W. Lamming 1,2,3,4,5 ✉ Protein-restricted diets promote health and longevity in many species. While the precise components of a protein-restricted diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of protein restriction can be attributed to reduced dietary levels of the branched-chain amino acids (BCAAs) leucine, isoleucine and valine. Here, we demonstrate that restricting dietary BCAAs increases the survival of two different progeroid mouse mod- els, delays frailty and promotes the metabolic health of wild-type C57BL/6J mice when started in midlife, and leads to a 30% increase in life span and a reduction in frailty in male, but not female, wild-type mice when they undergo lifelong feeding. Our results demonstrate that restricting dietary BCAAs can increase health span and longevity in mice and suggest that reducing dietary BCAAs may hold potential as a translatable intervention to promote healthy aging. ietary interventions can robustly promote organismal both Drosophila and rodents5,19–22.