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Sodium Selenate Hazard Summary Identification
Common Name: SODIUM SELENATE CAS Number: 13410-01-0 RTK Substance number: 1726 DOT Number: UN 2630 Date: November 2001 ------------------------------------------------------------------------- ------------------------------------------------------------------------- HAZARD SUMMARY WORKPLACE EXPOSURE LIMITS * Sodium Selenate can affect you when breathed in and The following exposure limits are for Selenium compounds may be absorbed through the skin. (measured as Selenium): * Contact can irritate the skin and eyes. * Breathing Sodium Selenate can irritate the nose, throat OSHA: The legal airborne permissible exposure limit 3 and lungs causing coughing, wheezing and/or shortness of (PEL) is 0.2 mg/m averaged over an 8-hour breath. workshift. * High exposure can cause headache, nausea, vomiting, NIOSH: The recommended airborne exposure limit is coated tongue, metallic taste and garlic odor on the breath. 3 * Repeated exposure can cause pallor, nervousness and 0.2 mg/m averaged over a 10-hour workshift. mood changes. ACGIH: The recommended airborne exposure limit is * Sodium Selenate may damage the liver and kidneys and 3 affect the heart. 0.2 mg/m averaged over an 8-hour workshift. * The above exposure limits are for air levels only. When IDENTIFICATION skin contact also occurs, you may be overexposed, even Sodium Selenate is a white, sand-like solid. It is used as a though air levels are less than the limits listed above. medication and an insecticide. WAYS OF REDUCING EXPOSURE REASON FOR CITATION * Where possible, enclose operations and use local exhaust * Sodium Selenate is on the Hazardous Substance List ventilation at the site of chemical release. If local exhaust because it is regulated by OSHA and cited by ACGIH, ventilation or enclosure is not used, respirators should be DOT, NIOSH, DEP and EPA. -
Notice of Modification to the List of Permitted Food Enzymesto Enable
Notice of Modification to the List of Permitted Food Enzymes to Enable the Use of Lysophospholipase from Trichoderma reesei RF7206 in the Production of Sugars and Dextrins from Starch Notice of Modification – Lists of Permitted Food Additives Reference Number: NOM/ADM-0172 August 10, 2021 Summary Food additives are regulated in Canada under Marketing Authorizations (MAs) issued by the Minister of Health and the Food and Drug Regulations (Regulations). Approved food additives and their permitted conditions of use are set out in the Lists of Permitted Food Additives that are incorporated by reference in the MAs and published on the Canada.ca website. A petitioner can request that Health Canada approve a new additive or a new condition of use for an already approved food additive by filing a food additive submission with the Department's Food Directorate. Health Canada uses this premarket approval process to determine whether the scientific data support the safety of food additives when used under specified conditions in foods sold in Canada. Health Canada’s Food Directorate received a food additive submission seeking approval for the use of lysophospholipase from Trichoderma reesei RF7206 in starch used in the production of dextrins, dextrose, fructose syrups and solids, glucose (glucose syrup), glucose solids (dried glucose syrup), or maltose. The food enzyme is intended to be used at a level consistent with Good Manufacturing Practice1. Its purpose of use is to improve the efficiency of the starch processing. Lysophospholipase is a type of phospholipase. Phospholipase from other microbial sources is already permitted for use in Canada as a food enzyme in certain foods, but not in the production of sugars and dextrins from starch. -
Using Sodium and Potassium Bicarbonates in the Prevention and Treatment of All Sickness and Disease
International Journal of Complementary & Alternative Medicine Using Sodium and Potassium Bicarbonates in the Prevention and Treatment of all Sickness and Disease Abstract Mini Review This article suggests that the use sodium and potassium bicarbonates are non- Volume 9 Issue 6 - 2017 toxic primary alkalizing agents in the prevention and treatment of all cancers, kidney disease, liver disease, Type I & Type II diabetes, Lupus, heart disease, Pharmacological toxicosis, vascular surgery operation, tonsillar herniation due Universal Medical Imaging Group, USA to cerebral edema, lactic acid toxicosis, and hyponatremia or low salt or loss of salts due to excessive or over-exercise! *Corresponding author: Robert O Young, Universal Medical Imaging Group, 16390 Dia Del Sol Valley Center, California Keywords: Cancer; Diabetes; Lupus; Heart disease; Vascular surgery; 92082, USA, Tel: 760 751 8321; Herniation; Cerebral edema; Lactic acid toxicosis; Liver disease; Kidney disease; Email: Hyponatremia; Pharmacological toxicosis Received: January 10, 2016 | Published: December 08, 2017 Introduction Sodium and potassium bicarbonate increases the hydroxyl ions or electron levels through increased alkalinity to the cells Sodium and potassium bicarbonate are excellent agents for buffering the metabolic acids that can cause cancer [20]. It is a natural alkaline approach in the treatment for all sickness and also one of the most basic medicines in allopathic and alternative disease, including cancer. Sodium bicarbonate is the universal medicine we have for the treatment of kidney disease. Research by mainstream treatment of acidosis. It is used every day by British scientists at the Royal London Hospital shows that sodium oncologists to neutralize the heavy acidic nature of their chemical bicarbonate can dramatically slow the progress of chronic kidney and chemotherapeutic agents which are often quite toxic. -
Food and Drug Administration, HHS § 184.1639
Food and Drug Administration, HHS § 184.1639 (2) The ingredient is used in food at Academy Press, 2101 Constitution Ave. levels not to exceed current good man- NW., Washington, DC 20418, or may be ufacturing practice. examined at the National Archives and (d) Prior sanctions for this ingredient Records Administration (NARA). For different from the uses established in information on the availability of this this section do not exist or have been material at NARA, call 202–741–6030, or waived. go to: http://www.archives.gov/ federallregister/ [48 FR 52444, Nov. 18, 1983] codeloflfederallregulations/ § 184.1634 Potassium iodide. ibrllocations.html. (c) The ingredient is used as a dough (a) Potassium iodide (KI, CAS Reg. strengthener as defined in § 170.3(o)(6) No. 7681–11–0) is the potassium salt of of this chapter. hydriodic acid. It occurs naturally in (d) The ingredient is used in the man- sea water and in salt deposits, but can ufacture of bread in accordance with be prepared by reacting hydriodic acid § 184.1(b)(2) of this chapter in an (HI) with potassium bicarbonate amount not to exceed 0.0075 percent (KHCO ). 3 based on the weight of the flour. (b) The ingredient meets the speci- (e) Prior sanctions for this ingredient fications of the ‘‘Food Chemicals different from the uses established in Codex,’’ 3d Ed. (1981), pp. 246–247, which this section do not exist or have been is incorporated by reference. Copies waived. may be obtained from the National Academy Press, 2101 Constitution Ave. [43 FR 11699, Mar. 21, 1978, as amended at 49 NW., Washington, DC 20418, or may be FR 5613, Feb. -
Alkanoyl Lactyl Lactate Salts As Used in Cosmetics
Safety Assessment of Alkanoyl Lactyl Lactate Salts as Used in Cosmetics Status: Final Report Release Date: July 17, 2019 Panel Date: June 6-7, 2019 The 2019 Cosmetic Ingredient Review Expert Panel members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; Ronald A. Hill, Ph.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; James G. Marks, Jr., M.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. The CIR Executive Director is Bart Heldreth, Ph.D. This report was prepared by Wilbur Johnson, Jr., M.S., Senior Scientific Analyst. © Cosmetic Ingredient Review 1620 L STREET, NW, SUITE 1200 ◊ WASHINGTON, DC 20036-4702 ◊ PH 202.331.0651 ◊ FAX 202.331.0088 ◊ [email protected] ABSTRACT: The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of 10 alkanoyl lactyl lactate salts. These ingredients have the surfactant function in cosmetics in common. The Panel reviewed data relevant to the safety of these ingredients, and concluded that these 10 ingredients are safe in cosmetics in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be based on a quantitative risk assessment (QRA) or other accepted methodologies. INTRODUCTION The safety of the following 10 alkanoyl lactyl lactate salts as used in cosmetics is reviewed in this Cosmetic Ingredient Review (CIR) safety assessment. Calcium Stearoyl Lactylate Sodium Cupheoyl Lactylate Sodium Behenoyl Lactylate Sodium Isostearoyl -
(12) United States Patent (10) Patent No.: US 7,211,656 B2 Mukerji Et Al
US00721 1656B2 (12) United States Patent (10) Patent No.: US 7,211,656 B2 Mukerji et al. (45) Date of Patent: May 1, 2007 (54) DESATURASE GENES, ENZYMES ENCODED Doerks et al., TIG 14(6): 248-250, Jun. 1998.* THEREBY, AND USES THEREOF Smith et al. Nature Biotechnology 15: 1222-1223, Nov. 15, 1997.* Brenner, S.E., TIG 15(4): 132-133, Apr. 1999.* (75) Inventors: Pradip Mukerji, Gahanna, OH (US); Bork et al., TIG 12(10): 425-427, Oct. 1996.* Suzette L. Pereira, Westerville, OH Leslie, C. G. et al., “Dietary (n-9) Eicosatrienoic Acid from a (US); Yung-Sheng Huang, Upper Cultured Fungus Inhibits Leukotriene B4 Synthesis in Rats and the Arlington, OH (US) Effect Is Modified by Dietary Linoleic Acid' ', Amer Journ of Clin Nutrit, 126(6): 1534-1540 (1996). Jareonkitmongkol, S., et al., “Production of an Eicosapentaenoic (73) Assignee: Abbott Laboratories, Abbott Park, IL Acid-Containing Oil by a A12 Desaturase-Defective Mutant of (US) Mortierella alpina 1S-4”, Journ of the Amer Oil Chemists Soc. 70(2): 119-123 (1993). (*) Notice: Subject to any disclaimer, the term of this Pereira, S.L., et al., “A novel (p-fatty acid desaturase involved in the patent is extended or adjusted under 35 biosynthesis of eicosapentaenoic acid”. The Biohem Journ, U.S.C. 154(b) by 444 days. 378(2):665-671 (2004). Ziboh, V.A., et al., Metabolism of polyunsaturated fatty acids by (21) Appl. No.: 10/060,793 skin epidermal enzymes: generation of anti-inflammatory and antiproliferative metabolites 1-3, Amer Journ of Clin Nutri, (22) Filed: Jan. -
Felix Ekness
ABSTRACT A Synthetic Biology Approach to Engineering Bacterial Two- Component Systems for Sensor Development and Discovery of Anti-Virulence Agents by Felix Ekness Bacterial two-component systems (TCSs) are the largest family of signal transduction pathways that enable bacteria to sense a diversity of stimuli including small peptides, environmental pollutants, and light. Canonical TCSs are composed of a transmembrane sensor histidine kinase (SK) that converts stimulus detection into phosphorylation of a cognate response regulator (RR). Upon phosphorylation, the cytoplasmic RR binds target output promoters, hereby modulating gene expression. TCSs are valuable sensors for synthetic biology due to their diverse sensing capabilities and straightforward transduction of detected stimulus into transcriptional regulation. TCSs are also emerging targets for novel therapeutic development due to their extensive role in regulating bacterial virulence and antibiotic resistance. Although TCSs are exciting sensors for synthetic biology and targets for therapeutic applications, most TCSs remain difficult to harness for applications and study due to output promoters that are unknown, subject to cross- regulation, or silent in heterologous hosts. In the first portion of my work, I develop a method to overcome the hurdles in characterizing and utilizing TCSs as biosensors. Through the framework of synthetic biology, I demonstrate that the two largest families of RR DNA binding domains (DBDs) can be interchanged with remarkable flexibility, enabling the corresponding TCSs to be rewired to synthetic output promoters. In collaboration with Kristina Daeffler, we exploit this plasticity to eliminate cross-regulation and in collaboration with Brian Landry, we un-silence a gram-negative TCS in a gram-positive host and engineer a sensor with over 1,300-fold activation. -
RIFM Fragrance Ingredient Safety Assessment, Anisyl Alcohol, CAS Registry T Number 105-13-5 A.M
Food and Chemical Toxicology 134 (2019) 110702 Contents lists available at ScienceDirect Food and Chemical Toxicology journal homepage: www.elsevier.com/locate/foodchemtox Short Review RIFM fragrance ingredient safety assessment, anisyl alcohol, CAS registry T number 105-13-5 A.M. Apia, D. Belsitob, S. Bisertaa, D. Botelhoa, M. Bruzec, G.A. Burton Jr.d, J. Buschmanne, M.A. Cancellieria, M.L. Daglif, M. Datea, W. Dekantg, C. Deodhara, A.D. Fryerh, S. Gadhiaa, L. Jonesa, K. Joshia, A. Lapczynskia, M. Lavellea, D.C. Liebleri, M. Naa, D. O'Briena, A. Patela, T.M. Penningj, G. Ritaccoa, F. Rodriguez-Roperoa, J. Rominea, N. Sadekara, D. Salvitoa, ∗ T.W. Schultzk, F. Siddiqia, I.G. Sipesl, G. Sullivana, , Y. Thakkara, Y. Tokuram, S. Tsanga a Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA b Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA c Member Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE, 20502, Sweden d Member Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA e Member Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625, Hannover, Germany f Member Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil g Member Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. -
To FCC 11, First Supplement the Following Index Is for Convenience and Informational Use Only and Shall Not Be Used for Interpretive Purposes
Index to FCC 11, First Supplement The following Index is for convenience and informational use only and shall not be used for interpretive purposes. In addition to effective articles, this Index may also include items recently omitted from the FCC in the indicated Book or Supplement. The monographs and general tests and assay listed in this Index may reference other general test and assay specifications. The articles listed in this Index are not intended to be autonomous standards and should only be interpreted in the context of the entire FCC publication. For the most current version of the FCC please see the FCC Online. First Supplement, FCC 11 Index / Allyl Beta-phenylacrylate / I-1 Index Titles of monographs are shown in the boldface type. A 2-Acetyl Thiazole, 18 Alcohol C-8, 863 Acetyl Valeryl, 562 Alcohol C-9, 854 Abbreviations, 6, 1726 Acetyl Value, 1400 Alcohol C-10, 362 Absolute Alcohol (Reagent), 5, 1725 Achilleic Acid, 24 Alcohol C-11, 1231 Acacia, 556 Acid (Reagent), 5, 1725 Alcohol C-12, 681 ªAccuracyº, Defined, 1538 Acid-Hydrolyzed Milk Protein, 22 Alcohol C-16, 569 Acesulfame K, 9 Acid-Hydrolyzed Proteins, 22 Alcohol Content of Ethyl Oxyhydrate Acesulfame Potassium, 9 Acid Calcium Phosphate, 219 Flavor Chemicals (Other than Acetal, 10 Acid Hydrolysates of Proteins, 22 Essential Oils), 1437 Acetaldehyde, 10 Acidic Sodium Aluminum Phosphate, Alcohol, Diluted, 1524 Acetaldehyde Diethyl Acetal, 10 1065 Alcoholic Potassium Hydroxide TS, Acetaldehyde Test Paper, 1535 Acidified Sodium Chlorite 1524 Acetals (Essential Oils and Flavors), -
Sodium Acid Pyrophosphate (SAPP)
Sodium Acid Pyrophosphate (SAPP) Sodium acid pyrophosphate (Disodium pyrophosphate) is a buffering and chelating agent, with many food and industrial uses. It is polyvalent, and acts as a Lewis base, so is effective at binding polyvalent cations. It is manufactured by the reaction of sodium carbonate withphosphoric acid. followed by heating of the resulting sodium phosphate to 220 degrees Celsius. Specification: Trisodium Phosphate Anhydrous Identifiers SKU: D9028 Items Spec Food Grade Industrial Grade CAS number: 7758-16-9 HS Code: 2835.22.0000 Purity (as Na2H2P2O7) % ≥ 95 95 Properties % ≤ 0.002 Heavy Metal (as Pb) Molecular formula: Na2H2P2O7 Molar Mass: Arsenic (as) % ≤ 0.0003 221.94g/mol Fluoride (as F) % ≤ 0.005 Density: 1.1-1.3g/cm3 Melting Point: >600 °C 3.5-4.5 3.5-4.5 PH (1% aqueous solution) Appearance: white powder Solubility in Water: Water Insoluble % ≤ 1.0 1.0 11.9 g/100 mL (20°C ) Standard GB 2928-1999 HG 2928-1999 Protection Do not ingest. Do not breathe dust. In case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, acids. Packing and Storage In double layer bags of net weight of 25 Kg or 50 Kg, store at a cool, dry and well ventilated place. Applications Food uses Sodium acid pyrophosphate is a GRAS substance for food use. It is used in canned seafood to maintain color and reduce purge[clarification needed] during retorting. Retorting achieves microbial stability with heat. -
The International Pharmacopoeia
The International Pharmacopoeia THIRD EDITION Pharmacopoea internationalis Editio tertia Volume 4 Tests, methods, and general requirements Quality specifications for pharmaceutical substances, excipients, and dosage forms World Health Organization Geneva 1994 WHO Library Cataloguing in Publication Data The International Pharmacopoeia.- 3rd ed. Contents: v. 4. Tests, methods, and general requirements 1. Drugs -analysis 2. Drugs -standards ISBN 92 4 154462 7 (NLM Classification: QV 25) The World Health Organization welcomes requests for permission to reproduce or translate its publica- tions, in part or in full. Applications and enquiries should be addressed to the Of£ice of Publications, World Health Organization, Geneva, Switzerland, which will be glad to provide the latest information on any changes made to the text, plans for new editions, and reprints and translations already available. O World Health Organization, 1994 Publications of the World Health Organization enjoy copyright protection in accordance with the provi- sions of Protocol 2 of the Universal Copyright Convention. All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers' products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distin- guished by initial capital letters. -
Ab Initio Chemical Safety Assessment
Ab initio chemical safety assessment : A workflow based on exposure considerations and non-animal methods Elisabet Berggren, Andrew White, Gladys Ouedraogo, Alicia Paini, Andrea-Nicole Richarz, Frédéric Y. Bois, Thomas Exner, Sofia Batista Leite, L. van Grunsven, Andrew P. Worth, et al. To cite this version: Elisabet Berggren, Andrew White, Gladys Ouedraogo, Alicia Paini, Andrea-Nicole Richarz, et al.. Ab initio chemical safety assessment : A workflow based on exposure considerations and non-animal meth- ods. Computational Toxicology, 2017, 4, pp.31-44. 10.1016/j.comtox.2017.10.001. ineris-01863939 HAL Id: ineris-01863939 https://hal-ineris.archives-ouvertes.fr/ineris-01863939 Submitted on 29 Aug 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Computational Toxicology 4 (2017) 31–44 Contents lists available at ScienceDirect Computational Toxicology journal homepage: www.elsevier.com/locate/comtox Ab initio chemical safety assessment: A workflow based on exposure MARK considerations and non-animal methods ⁎ Elisabet Berggrena, , Andrew Whiteb,