Annual Review 2018– 2019
DR PATRICK PRENDERGAST PROVOST & PRESIDENT
Contents
01 01.0 Welcome from the Provost 02
02 02.0 Trinity at a Glance 06
03 03.0 Trinity’s Global Relations Strategy 14
04 04.0 Research Case Studies 20 04.1 Aonghus McNabola 22 04.2 David Finlay 24 04.3 David Shepherd 26 04.4 Eunan O’Halpin 28 04.5 Jarlath Killeen 30 04.6 Juliette Hussey 32 04.7 Lidia Tajber 34 04.8 Lorina Naci 36 04.9 Paula Colavita 38 04.10 Rachael Walsh 40 04.11 Sarah O’Brien 42 04.12 Timothy Savage 44
05 05.0 Inspiring Generations – The Campaign for Trinity 46
06 06.0 Research Charter and Living Research Excellence Strategy 50
07 0 7. 0 Innovation and Entrepreneurship 54
08 08.0 Public Engagement 58
09 09.0 The Student Experience 64
10 10.0 Healthy Trinity 68
11 11.0 Sport at Trinity 72
12 12.0 New Professor Interviews 76 12.1 Professor Andrew Murphy 78 12.2 Professor Blánaid Daly 81 12.3 Professor Ruth Karras 84
13 13.0 Trinity’s Visitors 88
14 14.0 Governance 92
15 15.0 Financial Elements 96
Annual Review 2018–2019 02 | 01 01
Welcome from the Provost
In a particularly busy and dynamic year, two launches Chapter 3). This builds on the dynamic initiatives we’ve put in place really stand out: on 2nd May we launched Inspiring Generations over the past decade. Our headline actions for the next five years in the Public Theatre - the first comprehensive philanthropic include: expanding our partnerships with like-minded universities campaign in the history of the university. Inspiring Generations round the world; further diversifying our student body and giving has two goals: to raise €400m in philanthropic donations to students more opportunities to study abroad; and continuing contribute to projects and initiatives that drive excellence across to integrate students into the global Trinity community. Global the university, and to inspire 150,000 volunteering hours from travel was a highlight of the year. I led a delegation to Morocco alumni and friends of Trinity around the world. You can read to discuss research collaboration and student exchange with about the campaign and its flagship projects in Chapter 5, key universities, as well as a trip to East and South Africa (Dar es Inspiring Generations. Salaam, Nairobi, Johannesburg, Cape Town) where we visited 10 Just three weeks later, on 23rd May came the for- universities/research institutes to discuss future collaboration mal opening of the Trinity Business School. Six years after we and partnerships, building on Trinity’s strong existing academic announced our intention to build this, it was thrilling to be relationships on the African continent. standing in this flagship new building, an iconic, contemporary The Student Experience is central to the Trinity design by Scott Tallon Walker, which houses Tangent, Trinity’s Education and Chapter 9 details our multiple co-curricular Ideas Workspace and the A & K Dargan theatre, now the largest and extra-curricular initiatives. A key development this year auditorium on campus. The Trinity Business School was enabled was growing the Zón Mac Léinn network of student spaces, by donations from graduates and friends and it’s their generosity to turn spaces into places where students can meet friends, and enthusiasm that gave us the confidence and ambition to recharge, and socialize. Two new spaces come into the network reach out worldwide for Inspiring Generations. this year - the Buttery after hours and a new space in the Trinity After the Dublin launch, I went on to launch Inspiring Biomedical Sciences Institute (TBSI) and three more spaces Generations in London, Paris, New York, and San Francisco, were identified for development; there’s now an App showing with plans for Asia launches in 2020. Trinity now has more than students their nearest Zón Mac Léinn. Chapter 11, Sport at 121,000 alumni in 150 countries, and research partnerships as Trinity, highlights how we engage students in sport, from the measured by joint publications numbered 2,905 in 2019 – in athletes who win medals to the 6,200 students who joined a all our initiatives for the university, we have to think globally. sports club this year and through their participation improved Another important launch this year was our not just their health and fitness, but their leadership, organi- third Global Relations Strategy, or ‘GRS3’, as we call it, (see sational and social skills.
Trinity College Dublin – The University of Dublin ≥ Inspiring Generations has two goals: to raise €400m in philanthropic donations to contribute to projects and initiatives that drive excellence across the university, and to inspire 150,000 volunteering hours from alumni and friends of Trinity around the world.
Annual Review 2018–2019 02 | 03 01.0 Welcome from the Provost 01
A milestone for the Healthy Trinity initiative this year As ever, public lectures, symposia, talks, exhibitions, was the introduction of a tobacco-free policy which removed films and performances were some of the key ways in which tobacco use from the entire campus, with three minor exceptions. Trinity delivered on our commitment to engage wider society. We You can read more about this, and other developments supporting talk about some of these in Chapter 8, Public Engagement. Some healthy behaviours as a natural part of life on campus in Chapter of my favourite events - choosing from a very competitive field - 10, Healthy Trinity. include Schrödinger at 75 – the Future of Biology, a symposium The student experience is also central to our innovation commemorating the 75th anniversary of Erwin Schrödinger’s and entrepreneurship initiatives which continue to go from strength iconic What is Life? lectures in Trinity in 1943, and attended by to strength. Chapter 7, Innovation and Entrepreneurship, presents five Nobel Prize-winners and some of the world’s most brilliant the key successes of staff and student innovation. science minds. I also enjoyed Hannah Sullivan speaking in Trinity Innovation comes out of outstanding research. In June when she won the inaugural John Pollard Foundation International we launched our first everResearch Charter and Living Research Poetry Prize; and the 3-D digital scan of the Museum Building on Excellence Strategy (see Chapter 6) at a special event in the the new interactive public website, makingvictoriandublin.com, Douglas Hyde Gallery. The Charter and Strategy are the result of which also has information on the building’s design, materials and a highly collaborative process, headed by the Dean of Research, history, from leading Trinity geologists and architectural historians. Prof Linda Doyle, which sought inputs from across the university. Do take a moment to check it out. The process identified seven core principles which form Trinity’s It’s been another exceptional Trinity year. My thanks Research Charter and six key actions for the Excellence Strategy. to the whole community - staff, students and alumni - for their In Chapter 4, Research Case Studies, we give a brief inspiration. snapshot of Trinity research, showcasing twelve researchers across three faculties engaging in urgent research – from measuring con- sciousness in comatose patients to developing technology solutions Dr Patrick Prendergast to reduce energy consumption in the water sector; from the Irish Provost & President contribution to Gothic horror to developing appropriate models of higher education for the digital age. And in Chapter 12, New Professor Interviews we talk to three new professors - in Medieval History, Special Care Dentistry and English Literature – and hear about the exciting research they’re undertaking in their disciplines.
Trinity College Dublin – The University of Dublin LEFT – Among the contributors and representatives of areas included in this Provost’s Review are, standing (L-R) Sally-Anne Fisher, Head of Communications; Dr Diarmuid O’Brien, Chief Innovation & Enterprise Officer; Martina Mullin, Health Promotion Officer; Prof Kevin O’Kelly, Dean of Students; Kate Bond, Director of Advancement, Trinity Development & Alumni; John Coman, Secretary to the College; Prof Linda Doyle, Dean of Research; Michelle Tanner, Head of Sport & Recreation; seated (L-R) Prof Juliette Hussey, Vice-President for Global Relations; Prof Juergen Barkhoff, Vice-Provost / Chief Academic Officer; and Prof Paula Murphy, Registrar
≥ The student experience is also central to our innovation and entrepreneurship initiatives which continue to go from strength to strength...
ABOVE – An Taoiseach Leo Varadkar TD, Provost Patrick Prendergast and TBS Dean, Prof Andrew Burke at the opening of the Trinity Business School
RIGHT – State-of-the-art interior of the new Trinity Business School
Annual Review 2018–2019 04 | 05 02
Trinity at a Glance
Trinity is Ireland’s No. 1 University
QS World University Ranking, THE World University Ranking, Academic Ranking of World Universities (Shanghai)
Trinity College Dublin – The University of Dublin ≥ A 427 year old university in the heart of Dublin city centre
Annual Review 2018–2019 6 | 7 02.1 Trinity at a Glance
Student Statistics 02 2019 | 2013 (7 year comparisons)
REGISTERED STUDENTS 5,122 13,285
4,472 12,174
POSTGRADUATES UNDERGRADUATES
16,509 18,407 1,596
14,871 16,646 1,175
FULL-TIME * PART-TIME *
* excludes students validated for another institution
40% 60%
42% 58%
MALE 97 FEMALE
ONLINE
ALUMNI CLUBS AND SOCIETIES 2019 | 2013
121,647 | 100,277 49 | 49 127 | 112
SPORTS CLUBS STUDENT SOCIETIES REPUBLIC OF IRELAND 80,723 | 74,170
GREAT BRITAIN 9,983 | 9,616 THE LARGEST SOCIETIES ARE:
NORTHERN IRELAND 4,641 | 4,621 THE VINCENT DE PAUL SOCIETY
USA 7,697 | 3,557 THE PHILOSOPHICAL SOCIETY (THE PHIL)
CANADA 1,393 | 1,162 DU PLAYERS
REST OF WORLD 17,210 | 7,151 THE COLLEGE HISTORICAL SOCIETY (THE HIST)
— The college historical society (the hist) is the oldest student society in the world, founded in 1770
Trinity College Dublin – The University of Dublin Student / Staff Statistics
Staff Statistics 2019 | 2013 (7 year comparisons)
TOTAL STAFF 131 895
189 785
TECHNICAL ACADEMIC
3,502* 1,018 112
819 2,937 143
ADMINISTRATIVE LIBRARY
495 851
346 * Full-time Equivalent 655
BUILDINGS & SERVICES RESEARCH
ACADEMIC STAFF* FACULTIES
59% 41%
63% 37% ARTS, HUMANITIES AND SOCIAL SCIENCES
IRISH INTERNATIONAL ENGINEERING, MATHEMATICS AND SCIENCE
* Headcount HEALTH SCIENCES
Annual Review 2018–2019 08 | 09 02.2 Trinity at a Glance
International Students SWEDEN 26 CZECH REPUBLIC 1 2019 | 2013 AUSTRIA 0 BOSNIA AND HERZEGOVINA 01 02
GERMANY 2 9 POLAND 2 (7 year comparisons)
DENMARK 14 SLOVAKIA 0
SWITZERLAND 0 HUNGARY 14
NORWAY 20 SERBIA 0
THE NETHERLANDS 6 LITHUANIA 06
LUXEMBOURG 42 LATVIA 02
BELGIUM 9 FINLAND 2
FRANCE 40 ROMANIA 17 RUSSIAN FEDERATION 46
CROATIA 0 ESTONIA 04 CANADA 206
SLOVENIA 0 BULGARIA 02
UNITED KINGDOM 4 4 BELARUS 0 KAZAKHSTAN 07 IRELAND 1 , 19 UKRAINE 0
ICELAND 01 ITALY 176 TURKEY 7 REP OF KOREA 1 USA 1101 MONGOLIA 01 ISLE OF MAN 01 MONACO 01 AZERBAIJAN 01 GEORGIA 01 JAPAN 19 SPAIN 124 MONTENEGRO 02 NEPAL 02 CHINA 1 CYPRUS 01 ARMENIA 0 PORTUGAL 1 REP OF KOSOVO 02 SYRIA 01 IRAN, ISLAMIC REPUBLIC OF 14 BHUTAN 0 MALTA 17 LEBANON 02 MACAO 01 IRAQ 02 BANGLADESH 0 CAYMAN ISLANDS 01 JORDAN 06 KUWAIT 20 PAKISTAN MEXICO 14 GREECE 24 1 HONG KONG 2 PALESTINE 01 BAHRAIN 01 MOROCCO 0 INDIA 2 VIETNAM 0 TAIWAN REPUBLIC OF CHINA 16 LIBYAN ARAB JAMAHIRIYA 07 ISRAEL 04 PHILIPPINES ST KITTS AND NEVIS 01 EGYPT 07 THAILAND 09 10 UNITED GRENADA 01 GUINEA 01 NIGERIA GUINEA 01 22 SUDAN 02 ARAB EMIRATES 19 COSTA RICA 02 ANTIGUA AND BARBUDA 01 ETHIOPIA 01 MYANMAR 01 SIERRA LEONE COLOMBIA 01 OMAN BRUNEI DARUSSALAM 0 GHANA KENYA 09 MALAYSIA 117 09 TRINIDAD AND TOBAGO 11 02 UGANDA 01 04 LIBERIA ECUADOR 01 SAUDI ARABIA 02 BURUNDI INDONESIA 0 01 SRI LANKA 0 QATAR 0 VENEZUELA 02 CAMEROON 02 SINGAPORE 246 PERU 07 TANZANIA 02 CONGO 02 BRAZIL 41 MALAWI 01 MAURITIUS 07 BOLIVIA 02 ZIMBABWE 0 AUSTRALIA SWAZILAND 01 CHILE 0 SOUTH AFRICA 26 URUGUAY 01
NEW ZEALAND 06 ARGENTINA 02 LESOTHO 01
103 | 109 1,523 | 583 61 | 33
AFRICA ASIA OCEANIA
ALGERIA 0 | 1 MOROCCO 3 | 2 AZERBAIJAN 1 | 2 MACAO 1 | 2 AUSTRALIA 55 | 26 ANGOLA 0 | 0 MOZAMBIQUE 0 | 1 BAHRAIN 1 | 2 MALAYSIA 117 | 107 FIJI 0 | 0 BOTSWANA 0 | 5 NIGER 0 | 1 BANGLADESH 3 | 7 MYANMAR 1 | 0 NEW ZEALAND 6 | 7 BURUNDI 1 | 0 NIGERIA 22 | 33 BHUTAN 3 | 0 NEPAL 2 | 0 TOTAL 61 | 33 CAMEROON 2 | 1 RWANDA 0 | 1 BRUNEI DARUSSALAM 9 | 1 OMAN 9 | 3
CONGO 2 | 0 SIERRA LEONE 1 | 0 CHINA 351 | 99 PAKISTAN 15 | 17 EGYPT 7 | 3 SOMALIA 0 | 0 HONG KONG 32 | 1 PALESTINE 1 | 0 ETHIOPIA 1 | 3 SOUTH AFRICA 26 | 18 INDIA 532 | 90 PHILIPPINES 10 | 10 GAMBIA 0 | 0 SUDAN 2 | 6 INDONESIA 3 | 1 QATAR 3 | 1 GHANA 2 | 0 SWAZILAND 1 | 0 ISLAMIC REP OF IRAN 14 | 12 REP OF KOREA 18 | 14 GUINEA 1 | 0 TANZANIA 2 | 1 IRAQ 2 | 7 SAUDI ARABIA 35 | 24 KENYA 4 | 4 TUNISIA 0 | 0 ISRAEL 4 | 1 SINGAPORE 246 | 120 LESOTHO 1 | 1 UGANDA 1 | 3 JAPAN 19 | 16 SRI LANKA 3 | 2 LIBYA 7 | 6 ZAMBIA 0 | 3 JORDAN 6 | 6 SYRIAN ARAB REPUBLIC 1 | 1 LIBERIA 1 | 0 ZIMBABWE 8 | 5 KAZAKHSTAN 7 | 16 TAIWAN REP OF CHINA 16 | 1 MALAWI 1 | 4 TOTAL 103 | 109 KUWAIT 20 | 8 THAILAND 9 | 1 MAURITIUS 7 | 7 LEBANON 2 | 1 UNITED ARAB EMIRATES 19 | 6 VIETNAM 8 | 3 TOTAL 1523 | 583
Trinity College Dublin – The University of Dublin International Students
SWEDEN 26 CZECH REPUBLIC 1
AUSTRIA 0 BOSNIA AND HERZEGOVINA 01
GERMANY 2 9 POLAND 2
DENMARK 14 SLOVAKIA 0
SWITZERLAND 0 HUNGARY 14
NORWAY 20 SERBIA 0
THE NETHERLANDS 6 LITHUANIA 06
LUXEMBOURG 42 LATVIA 02
BELGIUM 9 FINLAND 2
FRANCE 40 ROMANIA 17 RUSSIAN FEDERATION 46
CROATIA 0 ESTONIA 04 CANADA 206
SLOVENIA 0 BULGARIA 02
UNITED KINGDOM 4 4 BELARUS 0 KAZAKHSTAN 07 IRELAND 1 , 19 UKRAINE 0
ICELAND 01 ITALY 176 TURKEY 7 REP OF KOREA 1 USA 1101 MONGOLIA 01 ISLE OF MAN 01 MONACO 01 AZERBAIJAN 01 GEORGIA 01 JAPAN 19 SPAIN 124 MONTENEGRO 02 NEPAL 02 CHINA 1 CYPRUS 01 ARMENIA 0 PORTUGAL 1 REP OF KOSOVO 02 SYRIA 01 IRAN, ISLAMIC REPUBLIC OF 14 BHUTAN 0 MALTA 17 LEBANON 02 MACAO 01 IRAQ 02 BANGLADESH 0 CAYMAN ISLANDS 01 JORDAN 06 KUWAIT 20 PAKISTAN MEXICO 14 GREECE 24 1 HONG KONG 2 PALESTINE 01 BAHRAIN 01 MOROCCO 0 INDIA 2 VIETNAM 0 TAIWAN REPUBLIC OF CHINA 16 LIBYAN ARAB JAMAHIRIYA 07 ISRAEL 04 PHILIPPINES ST KITTS AND NEVIS 01 EGYPT 07 THAILAND 09 10 UNITED GRENADA 01 GUINEA 01 NIGERIA GUINEA 01 22 SUDAN 02 ARAB EMIRATES 19 COSTA RICA 02 ANTIGUA AND BARBUDA 01 ETHIOPIA 01 MYANMAR 01 SIERRA LEONE COLOMBIA 01 OMAN BRUNEI DARUSSALAM 0 GHANA KENYA 09 MALAYSIA 117 09 TRINIDAD AND TOBAGO 11 02 UGANDA 01 04 LIBERIA ECUADOR 01 SAUDI ARABIA 02 BURUNDI INDONESIA 0 01 SRI LANKA 0 QATAR 0 VENEZUELA 02 CAMEROON 02 SINGAPORE 246 PERU 07 TANZANIA 02 CONGO 02 BRAZIL 41 MALAWI 01 MAURITIUS 07 BOLIVIA 02 ZIMBABWE 0 AUSTRALIA SWAZILAND 01 CHILE 0 SOUTH AFRICA 26 URUGUAY 01
NEW ZEALAND 06 ARGENTINA 02 LESOTHO 01
15,161 | 15,093 158 | 90 1,337 | 718 64 | 19
EUROPE EU EUROPE NON EU NORTH/CENTRAL AMERICA SOUTH AMERICA
AUSTRIA 30 | 20 ISLE OF MAN 1 | 0 ALBANIA 0 | 2 ANTIGUA AND BARBUDA 1 | 0 ARGENTINIA 2 | 0
BELGIUM 98 | 61 ITALY 176 | 74 ARMENIA 3 | 0 BAHAMAS 0 | 1 BOLIVIA 2 | 0 BULGARIA 2 | 3 LATVIA 2 | 3 BELARUS 3 | 1 BARBADOS 0 | 1 BRAZIL 41 | 12 CROATIA 8 | 0 LITHUANIA 6 | 11 BOSNIA & HERZEGOVINA 1 | 1 BERMUDA 0 | 1 CHILE 5 | 4 CYPRUS 1 | 8 LUXEMBOURG 42 | 12 CANARY ISLANDS 0 | 2 CANADA 206 | 158 COLOMBIA 2 | 2 CZECH REPUBLIC 13 | 7 MALTA 17 | 4 GIBRALTAR 0 | 1 CAYMAN ISLANDS 1 | 1 ECUADOR 2 | 0 DENMARK 14 | 11 POLAND 28 | 40 GEORGIA 1 | 0 COSTA RICA 2 | 0 PARAGUAY 0 | 0 ESTONIA 4 | 1 PORTUGAL 13 | 10 ICELAND 1 | 1 DOMINICAN REPUBLIC 0 | 0 PERU 7 | 1 FINLAND 23 | 18 ROMANIA 17 | 11 MACEDONIA 0 | 0 GUATEMALA 0 | 0 URUGUAY 1 | 0 FRANCE 340 | 205 SLOVAKIA 3 | 6 MOLDOVA 0 | 3 HAITI 0 | 1 VENEZUELA 2 | 0 GERMANY 259 | 190 SLOVENIA 5 | 1 MONACO 1 | 0 MEXICO 14 | 10 TOTAL 64 |19 GREAT BRITAIN 484 | 637 SPAIN 124 | 70 MONTENEGRO 2 | 0 PUERTO RICO 0 | 0 GREECE 24 | 22 SWEDEN 26 | 28 NORWAY 20 | 14 SAINT KITTS & NEVIS 1 | 0 GUERNSEY 0 | 0 THE NETHERLANDS 68 | 35 REPUBLIC OF KOSOVO 2 | 0 TRINIDAD & TOBAGO 11 | 5 HUNGARY 14 | 5 TOTAL 15,161 | 15,093 RUSSIAN FEDERATION 46 | 36 USA 1101 | 540 IRELAND 13319 | 13,600 SERBIA 3 | 1 TOTAL 1337 | 718 SWITZERLAND 30 | 19 TURKEY 37 | 8 UKRAINE 8 | 1 TOTAL 158 | 90
Annual Review 2018–2019 10 | 11 02.3 Trinity at a Glance 02 Library
LIBRARY COLLECTION HAS
6,500,000 400,000 PRINTED ITEMS ELECTRONIC BOOKS plus access to 500,000 ebook titles via UK 01 electronic Legal Deposit 650,000 BOOK 150,000 MAPS OF KELLS ELECTRONIC JOURNALS plus access to 5,000,000 ejournal articles via UK electronic Legal Deposit
TRINITY’S RESEARCH THEMES
— AGEING — GENES AND SOCIETY — MANUSCRIPT, BOOK & PRINT CULTURES
— CANCER — IDENTITIES IN TRANSFORMATION — NANOSCIENCE
— CREATIVE ARTS PRACTICE — IMMUNOLOGY, INFLAMMATION & INFECTION — NEUROSCIENCE
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— TRINITY COLLEGE INSTITUTE OF NEUROSCIENCE (TCIN)
— TRINITY LONG ROOM HUB, ARTS AND HUMANITIES RESEARCH INSTITUTE (TLRH) 05 — TRINITY TRANSLATIONAL MEDICINE INSTITUTE (TTMI)
Trinity College Dublin – The University of Dublin Library / Commercialisation of Research
Commercialisation of Research 2019 | 2014 (6 year comparisons)
374 | 308 04 | 04 13 | 23
INVENTION DISCLOSURES TRINITY CAMPUS COMPANIES NEW PATENT APPLICATIONS FILED
141 | 81 62 | 58 40 | 32
LICENCES TO INDUSTRY DISCLOSURES OF NOVEL INTELLECTUAL COLLABORATIVE RESEARCH PROPERTY AGREEMENTS WITH INDUSTRY EACH <€25K
22 | 37 16 | 28 67 | 51
TRINITY CAMPUS COMMERCIALISATION LICENCES COLLABORATIVE RESEARCH COMPANIES APPROVED TO INDUSTRY AGREEMENTS WITH INDUSTRY EACH >€25K
CONSOLIDATED FINANCIAL STATEMENTS €379.2m €356.2m €335.8m €323.0m €305.7m
TOTAL INCOME FOR TOTAL INCOME FOR TOTAL INCOME FOR TOTAL INCOME FOR TOTAL INCOME FOR YEAR ENDED 2018 YEAR ENDED 2017 YEAR ENDED 2016 YEAR ENDED 2015 YEAR ENDED 2014 (EXCLUDING GRANT (EXCLUDING GRANT (EXCLUDING GRANT (EXCLUDING GRANT (EXCLUDING GRANT AMORTISATION) AMORTISATION) AMORTISATION) AMORTISATION) AMORTISATION)
€m €m FINANCIAL YEAR 2012 2018
STATE GRANTS €58.70 €48.7
ACADEMIC FEES €113.80 €149.0
RESEARCH GRANTS AND CONTRACTS €75.90 €99.7
COMMERCIAL REVENUE UNIT INCOME €27.10 €44.4
OTHER INCOME €22.40 €15.4
ENDOWMENT AND INVESTMENT INCOME €6.60 €22.0
INCOME (EXCLUDING GRANT AMORTISATION) €304.50 €379.2
Annual Review 2018–2019 12 | 13 03
Trinity’s Global Relations Strategy
Trinity launched its ambitious The launch of GRS 3 provided an opportunity to look back and new Global Relations strategy, celebrate the developments in Global Relations that have taken place since 2012. Global Relations is one of the gate- which builds on the university’s ways between Trinity and our global community of students, great recent successes in this staff, institutional partners, academic collaborators and area, in February 2019. alumni network. GRS 3 will see a step change in internationalisa- tion. Building on Trinity’s global reputation for education and research, GRS 3’s headline actions over the next five years are: — Further diversification and growth in the student body; — Expanding strategic partnerships with targeted universities around the world to increase, strengthen and leverage the global reach and impact of our research, education and innovation; — Providing more opportunities for our students to spend time studying in other countries; — Continuing to integrate students, whether based in Dublin or abroad, into the global Trinity community and enhancing the student experience.
RIGHT – International students during Freshers’ Week
Trinity College Dublin – The University of Dublin ≥ Global Relations is one of the gateways between Trinity and our global community of students, staff, institutional partners, academic collaborators and alumni network.
Annual Review 2018–2019 14 | 15 03.0 Trinity’s Global Relations Strategy 03
Table 1 2015/16 2016/17 2017/18 2018/19
No. of Junior Sophister 812 784 831 931 students who availed of outbound opportunities
Percentage availing of international 30% 29% 30% 34% study and experience (% is derived from the approximate number of Junior Sophister students, which is normally when students take up overseas opportunities)
A diverse and global student community Student international study and experience In terms of diversity, we have students from 119 countries Overall the international study and experience programme at registered in Trinity. In 2018/19, 5,088 students came from Trinity has increased in recent years, with just under 34% of outside of Ireland and 3,247 students came from outside the undergraduate student body that have access to these of Europe (approximately 28% and 18% respectively). The opportunities (Table 1 & Figure 2). In this context this global steady increase in non-EU students is illustrated in Figure 1. experience relates mainly to student exchange arrangements with a focus on outbound mobility. Data for international place- Figure 1. Non–EU Growth 2015/16 to 2018/19 ments/ projects as part of undergraduate programmes is also included where relevant. The ambition, as stated in GRS 3, is 3000 2 94 for this to increase to 50% by 2023/24. 2800 In the last year new student exchange agree- 2 70 2600 ments were signed and/or activated with: Monash University, Waseda University, Nanyang Technological University, American 2400 201 University of Beirut, University Mohammed V Rabat and the 21 2200 University of Florida. 2000 1 0 The number of junior sophister students who availed of outbound opportunities increased from 812 in 2015/16 to 1800 2015/16 2016/17 2017/18 2018/19 931 in 2018/19, as illustrated in Figure 2.
Non-Eu Growth (Excludes Singapore Institute of Technology) Figure 2. No. of Junior Sophister students who availed of out- Student recruitment activity includes relationship bound opportunities 2015/16 to 2018/19 management with key stakeholders such as students, parents, 950 international high school counsellors, university partners, 9 1 government bodies and an education agent network to diverse 900 international markets. Trinity is now represented by 102 edu- 850 cation agents in 38 different countries. 12 1 The International Foundation Programme (IFP), in 800 7 4 partnership with the Marino Institute, has helped Trinity achieve greater diversity in the undergraduate student body, with growth 750 from countries such as China and the establishment of a strong 700 brand presence in strategically important regions such as the 2015/16 2016/17 2017/18 2018/19 Middle East and South East Asia. In 2018/19 there were 80 No. of Junior Sophister student who availed of outbound opportunities students from 14 countries enrolled on the IFP.
Trinity College Dublin – The University of Dublin Below – Yun Yu celebrating her graduation day
Student inbound opportunities degree with Columbia University which commenced in 2018, There has been a steady increase in incoming students to three new programmes were approved in 2018/19 for intake in Trinity (exchange and fee paying) from 872 in 2015/16 to 1078 2020, namely History of Art and Architecture; Classics, Ancient in 2018/19 as illustrated in Figure 3. History and Archaeology; and Film. Discussions on the inclusion of programmes in Sciences are at an advanced stage and the Figure 3. Undergraduate incoming students (exchange and fee expectation is that these will also be open for intake in 2020. paying) 2015/16 to 2018/19 Global travel 1200 In October-November 2018 the Provost led a visit to Australia,
10 9 Singapore and Malaysia. Meeting alumni and cultivating stra- 1100 107 tegic relationships with universities such as the University of Melbourne, the University of Sydney, LASALLE College of Arts 1000 and Singapore Institute of Technology were the main objec- 926 72 tives. Increasing the number of student exchanges places is 900 in progress, as is early work on deeper partnerships in specific programmes. 800 2015/16 2016/17 2017/18 2018/19 In July 2019 the Provost led a delegation to Morocco to discuss research collaboration and student exchange with Undergraduate Incoming students (exchange and fee paying) the University of Mohammed V in Rabat and Al Akhawayn University in Ifrane. In both universities the Provost addressed Global partnerships staff and students on “Innovation and Entrepreneurship”, and The number of educational partnerships with universities Trinity’s success in this area. Later in July the Provost led a globally continues to grow and this year approval was given delegation to East and South Africa (Dar es Salaam, Nairobi, by the University Council for the programme with University Johannesburg, Cape Town) and visited 10 Universities/Research of Michigan-Shanghai Jiao Tong (SJTU) Joint Institute, which Institutes to discuss future collaboration and partnerships, will enable students to graduate with an MAI Engineering from building on Trinity’s strong existing academic relationships on Trinity and BSc from SJTU. Building on the success of the dual the African continent.
Annual Review 2018–2019 16 | 17 03.0 Trinity’s Global Relations Strategy
In addition to hosting 49 visits by universities in 2018/19 the Provost, Chief Innovation & Enterprise Officer and/ 03 or Vice-President for Global Relations and senior staff from her office made visits to the following universities:
Australia University of Sydney University of New South Wales University of Technology Sydney University of Melbourne University of Western Australia Monash University
Singapore Nanyang Technological University LASALLE College of Arts Singapore Management University Singapore Institute of Technology
Morocco University of Mohammed V Rabat Al Akhawayn University, Ifrane
Tanzania University of Dar es Salaam
Kenya University of Nairobi Strathmore University International Livestock Research Institute
South Africa University of Cape Town Stellenbosch University University of Witwatersrand University of Pretoria University of the Western Cape Nelson Mandela University
Israel Tel Aviv University Hebrew University of Jerusalem Weizmann Institute
USA Columbia University Bard College Duke University Penn State University Drexel University University of California, San Francisco
England University of Oxford Imperial College London University College London University of Birmingham
Canada University of Toronto
Trinity College Dublin – The University of Dublin TOP – Prof Juliette Hussey VP for Global Relations BOTTOM – Provost Patrick Prendergast with Prof William A. L. with Prof Sibongile Muthwa, Vice-Chancellor of Anangisye, Vice-Chancellor of the University of Dar es Salaam Nelson Mandela University in Port Elizabeth, South and colleagues during his trip to Tanzania Africa
European partnerships In June 2019 the European Commission announced the first 17 “European Universities” alliances. CHARM-EU was one of the successful applications. The CHARM-EU alliance is made up of the Universities of Barcelona, Trinity College Dublin, Utrecht, Montpellier and Eötvös Loránd (Budapest) together with associated and support partners including the Irish Universities Association (IUA) and the National agency Quality and Qualifications Ireland (QQI). CHARM-EU stands for a Challenge driven, Accessible, Research based, Mobile European University with a mission to create a sustainable, transferable, inclusive model for a European inter-university campus. Following on from high level visits in 2017/18, senior delegations from the Sorbonne and the University of Birmingham were received leading to the signing of bilateral agreements to collaborate in research and education programmes as well as staff and student mobility. Academic engagement with the University of Birmingham will focus, in the first instance, on digital human- ities, bioengineering and collaboration in medicine through the clinical research facilities in both universities. The strategic partnership with the Sorbonne University will focus on digital humanities, material science, Neuroscience/ GBHI, Cancer and Ageing research.
Annual Review 2018–2019 18 | 19 04
Research Case Studies
01 Aonghus McNabola 07 Lidia Tajber
02 David Finlay 08 Lorina Naci
03 David Shepherd 09 Paula Colavita
04 Eunan O’Halpin 10 Rachael Walsh
05 Jarlath Killeen 11 Sarah O’Brien
06 Juliette Hussey 12 Timothy Savage
Trinity College Dublin – The University of Dublin BACK (L–R) – David Finlay, Paula Colavita, Aonghus McNabola, Lidia Tajber, David Shepherd, Lorina Naci FRONT (L–R) – Eunan O’Halpin, Juliette Hussey, Jarlath Killeen
Annual Review 2018–2019 20 | 21 04.1 Research Case Studies
Reducing the energy consumption, cost 04 and environmental impact of water supply Aonghus McNabola
Water is a fundamental re- to be installed in water pipe networks to The energy from the turbine replaces source. Yet it is something we often take reduce pressure and leakage while also a diesel generator on the farm, and its for granted, and most of us will be unaware generating green electricity. associated air pollution. By avoiding the of the very significant cost and resources Conventional hydropower tur- purchase of €3,000 in diesel fuel annually, required to bring water to your door within bines are very large machines which cannot the turbine also reduces the cost of food very stringent quality criteria. be miniaturised to this scale economically. production for the farmer. The water supply sector is the I am leading the development of systems This research activity has been 4th most energy intensive sector in the EU to design and operate conventional water made possible by two EU projects I am and it is one that is responsible for consid- pumps in reverse to act as turbines. This leading, the €3.4 M Dwr Uisce Project, erable contributions to CO2 emissions and includes the development of software funded by the Interreg Ireland-Wales climate change as a result. Large amounts tools to predict the behaviour of a pump Programme and the €2.9 M REDAWN of energy are required to extract water from operating in reverse as a turbine. project funded by the Interreg Atlantic its source, treat it and distribute it across The new low-cost system has Area programme. many hundreds of kilometres of pipelines. been designed and installed at a water My work is focused on the development treatment works in County Wexford in of technology solutions which contribute Ireland in 2019. The system produces to the reduction of energy consumption 20-25% of the energy requirements of the of this sector. treatment works by reducing incoming water pressure through pipelines. The Reducing leaks and generating electricity resulting cost savings are being donated — A major source of inefficiency in water to the water development charity Wells supply systems is leakage. This has been for Life in Uganda. The associated CO2 estimated to be as high a 40-50% in Ireland. emissions of the works are also reduced The most effective method of reducing by up to 25% as a result of on-site green leakage is to reduce pressure in pipelines. electricity production. This is commonly carried out using pres- sure reducing valves or tanks, which expel Reducing pressures in food produc- the excess pressure to the atmosphere. tion — I have also applied this concept However this is a waste of the considerable to the irrigation sector in the south of energy consumption required to achieve Spain, reducing energy consumption this pressure to begin with. My research is in the production of walnuts and other leading the development and application water-intensive crops. Over 40% of water of low-cost hydropower turbines, designed in the EU is used in irrigation activity.
Aonghus McNabola received his BAI and PhD from Trinity and practiced as a Civil Engineer in industry before joining the School of Engineering as a Lecturer in 2007. He is now Associate Professor in Environmental Fluid Dynamics and Head of the Department of Civil, Structural & Environmental Engineering. He has published over 75 peer-reviewed journal articles. His research focuses on the engineering of fluid systems to improvements in energy efficiency, such as water supply and air pollution control. Contact: [email protected]
Trinity College Dublin – The University of Dublin Reducing the energy consumption, cost and environmental impact of water supply – Aonghus McNabola
LEFT – Hydropower installation at TOP – Walnuts BOTTOM – Walnut farm & irrigation pipes, Palma del Rio, Spain, reducing water pressure Palma del Rio, Spain at a Walnut farm, generating green electricity and replacing a diesel generator.
≥ A major source of inefficiency in water supply systems is leakage. This has been estimated to be as high a 40–50% in Ireland.
Annual Review 2018–2019 22 | 23 04.2 Research Case Studies
Fuelling our immune system 04 David Finlay
Therapeutic manipulation of However, these metabolic processes can the presence or absence of glucose and our immune systems is a new and poten- be disrupted during disease, leading to change their behaviour accordingly. The tially ground-breaking way of treating NK cells that do not work properly. For EU has funded an ERC Consolidator award diverse diseases. For instance, it is now instance, our work in collaboration with to allow my lab to investigate the new clear that, if given proper instruction, the Lydia Lynch and Andrew Hogan shows concept that nutrients are important immune systems of cancer patients can that NK cells from individuals with obesity signals that can shape immune responses. find and destroy tumours. The emergence cannot increase their metabolism when My research has made the of ‘check-point’ inhibitors as a revolution- activated and fail to kill tumour cells interesting discovery that starving ary cancer treatment is evidence of this. In partnership with Clair Dendritic cells (DC) of glucose enhances My research over the past Gardiner’s lab, our research teams at their ability to activate other immune cells. eight years has contributed to an exciting TBSI have revealed that NK cells from This starvation can result from competition transformation of classical immunology patients with metastatic breast cancer for glucose with neighbouring cells. When to reveal the importance of metabolic have abnormalities in the cellular pow- a DC is surrounded by glucose-hungry processes in shaping immune responses. erhouses called mitochondria. Normally cells the DC can become starved and the There is now a new understanding that mitochondria form elongated structures, nutrient switch called mTORC1 is turned the fuels available to immune cells and but the mitochondria in patient NK cells off leading to a change in DC behaviour the ways that these fuels are used have are shortened and have reduced energy (Figure 2). My lab is now studying the a substantial impact on immune cell production (Figure 1). We are investigat- complex relationship between the local function. We are now revealing novel and ing how these metabolic processes are availability of nutrients and the control exciting strategies to control immune cells disrupted in NK cells in these diseases. of our immune responses. through changing their metabolism - this The ultimate goal is to develop strate- has potential towards treating a range gies to provide NK cells with robust and of diseases. irrepressible metabolism and therefore enhanced abilities to protect us from NK cells operate through Natural Killer Cells — Natural Killer (NK) cancer and viral infection. directly killing their targets cells are a type of cytotoxic immune cell, by injecting cytotoxic “immune assassins”, with important roles Can nutrients shape immune responses? poisons. When NK cells in defending our bodies from cancer and I’m also interested in the different ways viral infection. NK cells operate through that metabolic fuels, or nutrients, control become activated they directly killing their targets by inject- our immune systems. For instance, in ramp up their metabolic ing cytotoxic poisons. When NK cells many immune cells glucose is impor- processes to allow them to become activated they ramp up their tant in fuelling metabolic processes to generate sufficient energy metabolic processes to allow them to make energy. But glucose can also act generate sufficient energy and to make as an immunological signal because and to make the tools they the tools they need to be effective killers. cells contain glucose sensors that detect need to be effective killers.
David Finlay is Associate Professor in Immunometabolism in the Schools of Biochemistry and Immunology, and Pharmacy and Pharmaceutical Science. A Trinity graduate, he was awarded a BA (Mod) in Biochemistry in 2001. He completed his PhD (2006) and postdoctoral training at the University of Dundee in Scotland and was elected to fellowship of Trinity College Dublin in 2018. He has been a principal investigator in the Trinity Biomedical Sciences Institute since 2011. His research expertise lies at the interface of immunology and cellular metabolism. Contact: [email protected]
Trinity College Dublin – The University of Dublin Fuelling our immune system – David Finlay
≥ The ultimate goal is to Key: mTORC1 signaling Dendritic Cell develop strategies to provide T cell NK cells with robust and irrepressible metabolism... Fed DC
Starved DC Fig 1. Competition for nutrients controls Dendritic cells (DC): T cells (green) clustering around a DC (purple) consume all the available nutrients, such as glucose, leading to the inhibition of nutrient sensing signaling pathways like mTORC1 (red). Inhibition of mTORC1 alters the function of DC leading to enhanced T cell immune responses. Dashed lines outline DCs of interest.
Fig 2. NK cells from the blood of healthy individuals (left) and patients with metastatic breast cancer were analysed for mitochondria (red) structure. The structure of mitochondria from breast cancer patients is altered and they are not making energy efficiently.
NK cells from healthy individuals NK cells from breast cancer patients
Annual Review 2018–2019 24 | 25 04.3 Research Case Studies
In living colour: Jewish scripture in stained glass 04 David Shepherd
Of all the English incursions selected churches in the United Dioceses young man. What inspired this grouping of into Ireland, amongst the least known of Dublin and Glendalough (Church of Old Testament characters in adolescence is one which took place in the latter half Ireland). In essence, my research asks how - a grouping found in no other church in of the 19th century. In 1850, there were the images of the Old Testament found Ireland? The tragic answer is to be found less than 40 stained glass windows to in these windows reflect those found in in their dedication to three siblings from be found in Anglican churches across earlier biblical paintings, how they relate one family, all struck down in their youth: the island of Ireland; by 1900 there were to other stained glass found in the same Maurice Nelligan, age 22, Helen, age 17 nearly 1,400, thanks in large part to the building and how these images have been and Matthew, just 15 - confirmation that Gothic revival championed by the English influenced by those who made them and here, as elsewhere, the Old Testament architect Pugin and the English firms which those for whom they were made. stories which appeared in the stained furnished the bulk of the stained glass Initial research has con- glass were bound up with the stories of installed in so many churches on both firmed the significance of ‘typology’, in the parishioners themselves. sides of the Irish Sea during this period. which events and people found in the The fruit of this project will be It is of, of course, little wonder Hebrew Bible/Old Testament (such as seen not only in the research published that this stained glass was populated Abraham’s near sacrifice of his son Isaac) in peer-reviewed journals, but also in the by stories from the life of Christ, but the are depicted in the stained glass win- equipping of local communities with the Victorians’ unbridled passion for their Bible dows as ‘types’ which prefigure events and education and tools they need to nurture ensured that figures from the Hebrew Bible people described in the New Testament a deeper appreciation of the interpretive (Old Testament) also featured prominently, (e.g. the ‘sacrifice’ of Christ on the cross). resources to be found in the fabric of their including well-known characters like David While some stained glass windows are own physical environment. and Moses and also more obscure figures ‘conventional’ in their interpretation of ones like Ahimelek, Miriam, Samuel and the Old Testament, others have come Initial research has Melchizedek. While this inheritance of to light which are profoundly personal. ancient Judaism is being increasingly In one parish church (Leeson confirmed the significance forgotten by contemporary worshipping Park) near the centre of Dublin, a set of of ‘typology’, in which communities, the vivid illustration of these three adjacent windows from the late events and people found stories in stained glass offers an impor- nineteenth century depicts Samuel the in the Hebrew Bible/Old tant opportunity for re-engagement both prophet, Miriam, the sister of Moses, and with the glass and the ancient stories Jacob from Genesis. As in other windows Testament... are depicted they interpret. of the time, Miriam is depicted as a young in the stained glass woman; however Samuel, often pictured as windows as ‘types’ From typology to tragedy — Thanks to a a very young child, appears here uniquely which prefigure events grant from the Irish Research Council, I am in late adolescence, while Jacob, who currently exploring how the Hebrew Bible appears in other windows as a grey- and people described has been interpreted in the stained glass of bearded patriarch, is also pictured as a in the New Testament.
David Shepherd received his BA from the University of Saskatchewan and PhD from Edinburgh University and joined the Loyola Institute as lecturer in Hebrew Bible/Old Testament in 2013. He was elected Fellow of Trinity College Dublin in 2018. The founding director of the Trinity Centre for Biblical Studies within the School of Religion, he has published widely on the Old Testament both in its ancient context and in the visual and performing arts of the late 19th and early 20th century. Contact: [email protected]
Trinity College Dublin – The University of Dublin In living colour: Jewish scripture in stained glass – David Shepherd
BACKGROUND – Stained glass window depicting Miriam from the Old Testament in Lesson Park Church © Reproduced with the permission of the Representative Church Body of the Church of Ireland; photograph by David Lawrence
≥ In 1850, there were less than 40 stained glass windows to be found in Anglican churches across the island of Ireland; by 1900 there were nearly 1,400...
Annual Review 2018–2019 2626 || 27
04.4 Research Case Studies
Afghanistan, the British Empire and 04 the Second World War belligerents, 1937-1947 Eunan O’Halpin
Britain formally recognised Small states in the post-WWI interna- government in Afghanistan, for forty years Afghanistan as an independent state only tional system: Afghanistan and Ireland the state proved remarkably successful in November 1921, just three weeks before This research aims to make a contribu- in securing its external interests and in the Anglo-Irish Treaty did the same for tion not only to the neglected history of managing its difficult Soviet and British Ireland. Both those settlements resulted decades of sophisticated and successful Indian frontiers. How this was achieved, in uncontrollable borders, unresolved Afghan management of external affairs, and what it says about the complex nature territorial issues, divided communities, and to the British Empire’s difficulties in of governance in Afghanistan, is of con- and complex political, economic and controlling its land borders, but to wider temporary as well as historical interest. geostrategic relationships. scholarship on the role of small weak I aim to produce a full mono- Arising from research for my states in the post-First World War inter- graph on this project in 2021. Significant book Spying on Ireland: British Intelligence national system of which Afghanistan and publications to date include articles in and Irish Neutrality during the Second Ireland are interesting examples. Holocaust and Genocide Studies (2016) World War (Oxford, 2008), I have devel- Finally, the study will cast more and Twentieth Century China (2017), and oped a deep interest in Britain’s political light on Irish contributions to British impe- co-authored entries in the Encyclopedia and strategic relationship with her other rial governance: key officials dealing with of Jews in the Islamic World Volume IV. awkward small neighbour, independent Afghanistan such as Sir Francis Wylie and Opposite is a dramatic illustra- Afghanistan, between 1921 and 1947. Sir Philip Vickery were Trinity graduates, tion of how a decoded cable concerning There is no accessible Afghan and other Irishmen involved include Sir Afghanistan could influence high policy: foreign policy archive, but British records Aubrey Metcalfe and Brigadier Bill Magan the consequence was a much-resented include decoded Afghan diplomatic (whom I interviewed in 2001). but successful Anglo-Soviet demarche communications, and those of other My underlying argument is which forced the Afghan government to powers dealing with Afghanistan, and clear: for all the apparent chaos, under expel Axis civilians in September 1941. these provide a unique insight into how development, and weakness of central Kabul saw the world and sought to pro- tect Afghanistan’s interests in the 1930s and 1940s in the face of not one diffi- ≥ For all the apparent chaos, cult neighbour, but four: China, Persia, British India, and the dreaded Godless under development, and weakness Soviet Union. The records also show how Afghanistan’s engagement with wider of central government in Afghanistan, Muslim issues across Central Asia and the Near and Middle East, from Palestine for forty years the state proved to China, was qualified by consideration of her relations with her powerful, feared remarkably successful in securing and demanding neighbours the Soviet Union and British India. its external interests...
Eunan O’Halpin received his BA and MA from UCD, and PhD from Cambridge. He worked in DCU’s Business School from 1982 to 2000, becoming the first Paddy Moriarty Professor of Government. Since 2000 he has held the Bank of Ireland Chair of Contemporary Irish History (1999) and was elected Fellow in 2003. He has published widely on aspects of 20th century British and Irish history, including bi-lateral and international relations. He makes extensive use of British, American and Irish archival holdings, and has particular expertise in exploiting diplomatic and intelligence records. Contact: [email protected]
Trinity College Dublin – The University of Dublin Afghanistan, the British Empire and the Second World War belligerents, 1937-1947 – Eunan O’Halpin
LEFT – Part of decoded cable from the Italian Legation RIGHT – Churchill’s impulsive response to this in Kabul to Rome, setting out reasons why the Afghan raw intelligence is reflected in this memo to government feels it will have to give in to British the Foreign Secretary. He rightly assumed that pressure to expel Axis civilians from the country. Kabul had been profoundly intimidated by the Note Churchill’s marginal marks in red ink on the Anglo-Soviet invasion of neighbouring Persia last paragraph. the previous month.
Annual Review 2018–2019 28 | 29 04.5 Research Case Studies
Understanding Irish Gothic literature 04 Jarlath Killeen
In the 1897 novel which first Irish Gothic — Much of my own research irresistible to hyphenated figures and introduced him to the world, Count Dracula has focused on answering questions like groups. As Ireland continues to grapple warns his enemies, ‘I spread over centuries this. I have demonstrated that the Gothic with its own in-between status, between and time is on my side’. He appears to in Ireland has a history that stretches tradition and post-modernity, Berlin and have been right. Not only is Dracula the back into the 17th and 18th centuries, Boston, Britain and Europe, the Gothic will best-known vampire of them all, he is and has had a major impact on shap- most likely continue to occupy a central one of the most recognisable characters ing ideas about what Ireland is like, and place in its literary scene. I am currently in literary history. what it means to claim particular kinds co-editing a collection of essays on Irish What is not as well-known, of Irish identity. Gothic literature for Edinburgh University however, is that he was the creation of My published work argues that Press with Christina Morin of the University a middle-class, Irish Protestant, Trinity what Frank O’Connor once termed “sub- of Limerick. graduate, who lived in Dublin for half of merged population groups” may well be his life. Moreover, if Bram Stoker provided attracted to and gravitate towards forms the world with the best example of the and genres that speak to their in-between male vampire, his fellow Dubliner, Joseph status, their religious, social, political and Sheridan Le Fanu, gave the world the personal liminality, and provide fantasy most significant female vampire ever in solutions to the real world difficulties Carmilla, the eponymous anti-heroine with which they are struggling. Through of his 1870 novella. An ‘unholy trilogy’ of monographs such as Gothic Ireland (2005), Trinity College-educated Gothic writers The Emergence of Irish Gothic Fiction is rounded-off by Charles Maturin, the (2013), essay collections on Bram Stoker author of Melmoth the Wanderer (1820), (2014) and Sheridan Le Fanu (2017), and now almost completely forgotten except the organisation of international confer- by scholars of horror fiction and the stu- ences on the major Irish Gothic in Trinity dents they continue to require to read his College, my aim has been to generate more enormous and labyrinthine masterpiece. scholarly interest in ‘Irish Gothic’ literature, Why (and how) did middle-class Irish and also suggest possible explanations Anglicans from nineteenth-century Dublin about the wider implications of a genre generate such extraordinary influential which has such mesmeric attraction for monsters? More generally, why has Ireland readers and audiences around the world. produced such a long and distinguished The Gothic, which is packed full line of Gothic, horror and ‘weird fiction’ of ‘in-between’ monsters, like vampires writers? (who are living and dead), may well be
Jarlath Killeen received his BA from Trinity College Dublin and his PhD from University College Dublin. He joined the School of English in 2006 as a lecturer in Victorian literature, and he is now the Head of School. He was elected Fellow of Trinity College Dublin in 2010. He is the author of five monographs, and has published widely on the work of Oscar Wilde, and Irish Gothic fiction. He is currently completing a study of the discourses of childhood in seventeenth and eighteenth century Irish writing. Contact: [email protected]
Trinity College Dublin – The University of Dublin Understanding Irish gothic literature – Jarlath Killeen
≥ The Gothic, which is packed full of ‘in-between’ monsters, like vampires (who are living and dead), may well be irresistible to hyphenated figures and groups.
LEFT– Death Mask of Joseph Sheridan Le Fanu. Courtesy of Anna and Francis Dunlop.
FAR LEFT – Bram Stoker by W. & D Downey photogravure, 1906 NPGx3769 Copyright National Portrait Gallery, London. Creative Commons.
Annual Review 2018–2019 30 | 31 04.6 Research Case Studies
Rehabilitation following a cancer diagnosis 04 Juliette Hussey
The National Cancer Registry the specifics of the cancer and its treat- not sufficient. This has led to a paradigm of Ireland reports an overall improve- ment. My research group in the Clinical shift for physiotherapists. In patients ment in cancer survival, including for Research Facility in St James’s Hospital surviving cancer, major behaviour change cancers traditionally associated with poor works closely with the Department of is needed to bring exercise levels to those outcomes. This has led to an increased Surgery and Prof John Reynolds to evaluate required for health benefits. population of cancer survivors, many of exercise interventions aimed at optimis- whom have physical and psychological ing therapeutic responses to exercise at Exercise specific to particular cancers needs that require interventions in order various time points. Different cancers have different rehabil- to optimise quality of life. Early work from my group has itation requirements. People surviving Physical functioning is affected revealed that, following treatment, breast complex cancers such as oesophageal can- by both the disease itself and the adverse cancer patients engaged in similar lev- cer are found to have significant physical side effects of treatment (surgery, chemo- els of physical activity as controls but and nutritional impairment, and surgery therapy, radiation) – studies show that had reduced muscle strength and aer- performed after chemo(radio)therapy patients complete initial treatment with obic fitness. Since activity levels in the can have a marked attritional impact on significantly reduced physical perfor- general population have decreased and overall wellbeing. Findings from the pro- mance (poor exercise tolerance, muscle approximately 65% of people in Ireland ject RESTORE (Rehabilitation Strategies weakness and lower levels of muscle are not engaging in enough physical following Esophagogastric Cancer), include mass with increased body fat). These activity, the aim of ensuring that patients significantly improved cardiorespiratory impairments need to be addressed to return to pre-diagnosis activity levels is fitness of disease-free patients without enable the patient to return to pre mor- bid functioning (participating in family life, return to work etc). Addressing the adverse changes in body composition and physical performance may also assist in the prevention of secondary disease, particularly cardiovascular disease which cancer survivors are at a greater risk of developing.
Specific personalised exercise pre- scription — While the general benefits of exercise in both the prevention and treatment of cancer are understood, less is known about specific personalised exercise prescription which considers
Juliette Hussey is a Professor in Physiotherapy in the School of Medicine and Vice President for Global Relations. She received her MSc from King’s College London and her PhD from Trinity. She was elected to fellowship in 2011. Her research focuses on evaluating exercise interventions aimed at increasing physical performance in patients undergoing treatment for cancer. She has obtained over €1.4 million in grant funding in 2018 from the Health Research Board and the Irish Cancer Society. Contact: [email protected]
Trinity College Dublin – The University of Dublin Rehabilitation following a cancer diagnosis — Juliette Hussey
LEFT – Exercise interventions aimed at optimising therapeutic responses to exercise are being evaluated
compromises in body composition. This of the disease result, respectively, in intensity interval training led to positive initial work formed proof of principle breathlessness on activity and difficulty changes in exercise tolerance in as little for rehabilitation programmes and was swallowing, which both lead to decreased as two weeks and work on a randomised the basis for RESTORE 2 (Rehabilitation exercise tolerance. Lower fitness levels control trial has begun. Strategies in Oesophagogastric and are associated with post-operative com- The expectation is that this Hepatopancreaticobiliary Cancer) which plications. Prehabilitation or exercise research over the coming four years will will investigate the efficacy of the pro- training pre-surgery is the obvious inter- provide the evidence to support guidelines gramme as it applies to a wider cohort of vention, but the time between diagnosis for rehabilitation including individualised cancer survivors (oesophagus, stomach, and surgery does not generally permit exercise prescription for patients with pancreas and liver). gains in exercise tolerance using typi- gastro-intestinal cancer and for preha- In patients with lung cancer cal exercise programmes. Early results bilitation for patients facing oesophageal or oesophageal cancer the symptoms from pilot work demonstrated that high or lung resection.
≥ Approximately 65% of people in Ireland are not engaging in enough physical activity, the aim of ensuring that patients return to pre-diagnosis activity levels is not sufficient.
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20 Fig 1 – Changes in Cardiorespiratory Fitness (VO2max (ml/min/kg)) from T0 to T2
Correcting for baseline values, cardiorespiratory 02 fitness levels were significantly higher in the 18 intervention group compared to the control group at T1 , 22.20(4.35) vs 21.41(4.49)ml/min/kg, ControlControl InterventionIntervention F(1,37)=19.67, p=.000*, partial eta squared (ηp2) =0.35, and at T2, 21.75(4.27) vs 20.74(4.65)ml/ 16 min/kg ,F(1,35)=13.29, p=.001*, ηp2 =0.28. T0 T1 T2 Time–point
Annual Review 2018–2019 32 | 33 04.7 Research Case Studies
How to make medicines more effective? 04 Lidia Tajber
Many therapeutic agents – Anti-crystal engineering — To address A collaborative approach — On the third both newly discovered and long existing the above problems, my research con- issue, testing the approach, we know - lack efficacy because they have diffi- centrates on: that critical issues with medicine design culty getting to the bloodstream when — firstly, understanding the origins of can’t be dealt with in isolation, so I have ingested and cannot therefore reach the poor solubility of active substances, engaged in several networks. Within the required therapeutic destination sites. — secondly, developing a suitable techno- Synthesis and Solid State Pharmaceutical Typically, the therapeutic agents, also logical strategy to tackle the problem and, Centre (SSPC), a unique collaboration called active pharmaceutical ingredients, — thirdly, testing the approach using a between industry partners and Irish and that are often given to patients as tablets panel of sophisticated instrumentation international academia, my research to swallow must fully disperse into individ- and in prototype formulations (simple has mainly concentrated on amorphous ual molecules following ingestion before medicine). (“cement”-devoid) materials for pharma- being taken up into the circulation, move On the first question, why does ceutical applications. My group is also about the body and show their pharma- it happen, the pharmaceutical industry involved in two European Commission cological effects. has coined the term “brick dust” for poorly (EC) supported collaborations: Nowadays, those active mole- soluble molecules, but often the issue — the Open Research Biopharmaceutical cules are invented using computer model- is not with the “bricks” but the “cement”, Internships Support (ORBIS) is composed ling to specifically deal with a given ailment e.g. the strong bonds that the molecules of six academic partners and four pharma- and to have minimum side effects, which develop to hold them together in an entity ceutical companies from Poland, Czechia, means that other properties of those called a crystal. Finland, Ukraine, Ireland, Germany and substances, such as solubility (the ability On the second issue, tackling the US to advance the current scientific, of therapeutic agents to dissolve into a the problem, breaking the “cement” can economic and social challenge of increas- solution containing individual molecules), be achieved by mixing the crystals with ing the effectiveness and productivity of are often overlooked. It means that the another substance that is able to break drug development processes. The core of oral medicine (e.g. tablets) will not work the bonds and keep the active molecules ORBIS is the intersectoral and interna- effectively or will not work at all. Also, many separate and readily available for absorp- tional exchange of researchers working companies may not engage in development tion. This approach is called “anti-crystal together on solving the problems with of poorly soluble therapeutic agents due to engineering”. (See Figure 1) medicine development; the enormous costs of transforming such My group in Trinity’s School of — for the project LongActNow, aca- molecules into medicines. Therefore, there Pharmacy and Pharmaceutical Sciences, demic partners from Ireland, Germany is a definite need for smart technological which is supported by Science Foundation and a pharmaceutical company based formulation approaches to make drug Ireland, aims to develop those multicom- in Belgium will work on injectable long molecules bioavailable, so the existing ponent mixtures, scientifically termed ionic acting medicines. and new medication to treat ailments liquids and deep eutectic mixtures, as a via- are of the highest efficacy and quality. ble approach to enhancing bioavailability.
Lidia Tajber received her MSc Pharm from Medical University of Silesia, Poland, and PhD from Trinity, where she is now an Associate Professor in Pharmaceutics and Pharmaceutical Technology and Director of Research in the School of Pharmacy and Pharmaceutical Sciences. She joined the School in 2007 as a lecturer. Lidia has published nearly 90 peer-reviewed manuscripts and is a co-inventor on patent applications. Her research focuses on fundamental and applied aspects of developing medicines containing poorly soluble drugs. Contact: [email protected]
Trinity College Dublin – The University of Dublin How to make medicines more effective? – Lidia Tajber
Fig 1. Schematic representation of the molecular arrangement of poorly soluble active substance (A) showing the “cement” in grey (top of figure) and comparison between the structures of conventional, solid forms of the active comprising another substance (excipient, E) and the novel, ionic liquid and deep eutectic mixtures, systems.