Dr. Raymond Carrelle WE Care Garcinia MSM Green Tea Boswellia Fucoxanthin Tumeric Chromium Ginger Cinnamon Alpha Lipoic Acid Berberine Magnesium Red Yeast Rice Garlic Bergamonte Co Enzyme Q10 Acetyl L Carnitine Reservetrol N Acetyle Cysteine Melatonin Glucosamine B12 Chondroitin Safety – supplements can interact with prescription medications and can cause side effects Research the company – do they do 3rd party testing of their product? Quality – you get what you pay for. Testing is expensive and will be reflected in the price. Be aware - your doctor may not know a lot about supplements or interactions. Tropical fruit Appears to block an enzyme called citrate lyase which your body uses to make fat May also have an affect on glucose and cholesterol levels Potential side effects: dizziness, dry mouth, headache, upset stomach, diarrhea Cautions: Leukotriene inhibitors (Singulair, Accolate), Diabetes meds that can cause hypoglycemia, Statin cholesterol meds, Blood thinners Dosing: 100 – 500mg 3 times/day with meals Polyphenols play a role in the ecology of most plants. Typically found in the leaf, bark, flower or fruits of plants EGCG is the major polyphenol in green tea and may increase resting metabolic rate and fat burning It may also improve insulin resistance and cholesterol, and have antioxidant effects Potential side effects: dizziness, insomnia, agitation, fatigue Cautions: blood thinners, Diabetes meds that can cause hypoglycemia Dosing: 100 – 750 mg daily (in divided doses) Found in wakame (edible brown seaweed) May increase metabolism and fat oxidation May reduce blood sugar and improve insulin resistance Potential side effects: none known Cautions: no known drug interactions, caution with diabetes meds that can cause hypoglycemia Dosing: 300mg twice/day Is a mineral essential for proper glucose metabolism and with insulin function May help with cholesterol Potential side effects: headache, sleep disturbance, mood changes Cautions: may inhibit thyroid medication absorption, caution with diabetes medications that can cause hypoglycemia Dosing: 200 mcg 1-3 times/day Potential benefits for healthy glucose metabolism Potential side effects: none known Cautions: no drug interactions known, caution with diabetes medications that can cause hypoglycemia Dosing: 1-3 grams/day (1 gram = 1/4 -1/2 tsp) Is a chemical found in the bark, roots and stems of plants including Oregon grape, Barberry, Tree Tumeric, Goldenseal and Yellowroot Can lower a1c, glucose, insulin and cholesterol Potential side effects: headache, nausea, vomiting, bloating Cautions: AVOID if taking Cyclosporine. Caution with diabetes meds that can cause hypoglycemia Dosing: 350 – 500mg 2-3 times/day Is made from yeast grown on rice Dietary staple in some Asian countries Contains compounds called monacolins that block the production of cholesterol. May also affect blood sugar. Cautions: blood thinners, diabetes medications that can cause hypoglycemia AVOID TAKING WITH STATIN MEDS Patients intolerant of statins may get similar reactions with red yeast rice Dosing: 1200mg twice/day Extract of the Bergomot fruit, a bitter citrus fruit found in Southern Italy. Is commonly used as a flavoring in Earl Grey tea May reduce cholesterol, raise HDL (good cholesterol), remove fatty deposits in the liver and lower blood sugar. Potential side effects: rare cases of GI upset, nausea, increased gas, diarrhea, constipation Cautions: no know interactions, but caution with using other cholesterol meds Dosing: 1000 – 2000mg daily Amino acid derivative that plays a vital role in helping the body turn fat into energy Can have benefits for cholesterol, Diabetes, neuropathy, chronic fatigue, Alzheimer’s Potential side effects: GI upset, nausea, vomiting Cautions: AVOID if history of seizures, may interfere with thyroid hormone meds Dosing: 1000 – 3000mg daily in divided doses Form of the amino acid cysteine that is found in high protein foods Can have benefits for COPD, cholesterol, chronic pain, OCD. Many other uses. Potential side effects: nausea, vomiting, diarrhea, constipation Cautions: can increase the effects of nitroglycerine. Potential concerns for triggering bronchospasm in asthma. Caution with blood thinners. Potential risk for cysteine kidney stones in prone patients Dosing: 500 – 1000mg twice/day Take Vitamin C 500 – 1500mg/day to reduce risk for stones Is produced naturally by the body to help build cartilage May stimulate the production of healthy, new cartilage Best known for treating joint pain and increasing mobility in people with osteoarthritis, esp of the knee. Potential side effects: nausea, diarrhea, bloating, headache Cautions: caution with blood thinners and with asthma Dosing: 1500 – 3000mg daily in divided doses Often found in combo with Chondroitin and MSM Substance that makes the cartilage in your joints resilient. One of the basic building blocks of most connective tissues May help pain and joint stiffness of osteoarthritis, esp of the knee Potential side effects: rare nausea, bloating, diarrhea Cautions: may interact with blood thinners Dosing: 1200mg daily in divided doses Chemical found in plants, animals and humans May benefit joint pains and arthritis, esp of the knee Potential side effects: nausea, diarrhea, bloating, headache, insomnia Cautions: no known interactions Dosing: 1500mg daily in divided doses The boswellia tree is a flowering plant native to regions of Africa and Asia. The biblical incense frankincense is made of resin from the boswellia tree Appears to have anti inflammatory properties by inhibiting enzymes called leukotrienes that contribute to inflammation and pain. Can have benefits for arthritis, bursitis, tendonitis, rheumatoid arthritis. Has also been researches in Crohn’s and Ulcerative Colitis. Potential side effects: rare diarrhea, skin rash, nausea, acid reflux Cautions: may interact with certain asthma / allergy meds called Leukotriene inhibitors (Singulair, Accolate) Dosing: 150 – 400mg 3 times/day, take with a fatty meal Best known as a spice. Is one of the main components of curry Has anti inflammatory and anti oxidant properties May benefit joint pain, arthritis, chronic pain, depression Potential side effects: nausea, diarrhea, increased bleeding Cautions: may interact with blood thinners Dosing: 500 – 2000mg daily in divided doses Has been used to treat nausea, motion sickness and arthritis pain. May potentially lower blood sugar Has anti inflammatory properties Potential side effects: rare Cautions: high doses could interfere with cardiac, diabetes and blood thinning meds Dosing: 1000 – 4000mg daily divided into 2-4 doses Is a fatty acid that is essential to the body’s production of energy Is an anti oxidant found in most foods, esp. kidney, liver, spinach, broccoli and yeast extract May have benefit in glucose/insulin function, diabetic neuropathy and chronic fatigue Potential side effects: rare Cautions: no known drug interactions. Caution if taking diabetes meds that can cause hypoglycemia Dosing: 50-100mg daily, but can take up to 1800mg daily Is a mineral that plays a role in over 300 enzyme reactions Foods high in magnesium include spinach, broccoli, sunflower seeds, almonds, sesame seeds, cashews, peanut butter, beans, peas, edemame Can help with migraines, insomnia, palpitations, muscle cramps (esp. nocturnal leg cramps) Is available in different forms: Magnesium citrate, Magnesium gluconate, Magnesium glycinate, Magnesium lactate Potential side effects: GI upset, diarrhea Cautions: is excreted in the kidneys so caution with chronic kidney disease; do not take with amiloride (heart medication); may increase absorption of some diabetes meds (esp Glipizide, Glyburide); hold if also taking any of the following antibiotics (Ciprofloxin, Avelox, Tetracycline, Doxycycline, Minocycline) Dosing: 120 – 500mg daily Has enzymes that can reduce cholesterol, blood pressure and platelet adhesion (clot formation) resulting in improved heart health Potential benefits for reducing coronary artery calcifications/plaque, lowering BP Potential side effects: GI upset, body odor, bad breath Cautions: blood thinners Dosing: 1 clove daily, 2400mg daily Improves the production of energy in cells Is an anti oxidant Can have benefits for CHF, blood pressure, cholesterol, side effects of statin medications (may reduce levels of CoQ10 in the body) and fibromyalgia Potential side effects: rare Cautions: blood thinners Dosing: 100 – 300mg daily divided 2-3 times/day A substance found in red wine, grapes, blueberries, raspberries, mulberries Potential heart protection effects – blood vessel dilator, prevent blood clots. Is also has anti oxidant and anti inflammatory properties. Potential side effects: rare Cautions: blood thinners; women on estrogen therapy (can have some possible estrogen like affects) Dosing: 20-60 mg daily divided into 2 doses Is a natural hormone produced by the pineal gland in the brain to regulate sleep Levels are suppressed during the day in response to sunlight, then rise at night to trigger sleep Has anti oxidant properties at higher doses Helpful for insomnia, sleep disturbances due to jet lag and shift work; may help with Chronic Fatigue Syndrome and Irritable Bowel Syndrome Potential side effects: drowsiness, GI discomfort, morning grogginess Cautions: may interact with Prozac (Fluoxetine); may increase the effects of sedating meds (Benzodiazepines and anti histamines) Dosing: 0.5 – 10 mg at bedtime Is essential for red blood cell production, healthy nerves, producing DNA Is not found in plant sources. Common food sources – beef, cheese, liver, eggs, salmon, sardines, trout, tuna Risks for deficiency: vegetarians, Metformin use, use of stomach acid medications, colchicine Potential side effects: none common No concerning interactions Dosing: 500-1000mcg daily. Available in oral, injection and nasal (Nascobol) forms Taking Vitamin C with B12 can increase improve its absorption .