Dr. Raymond Carrelle WE Care

 Garcinia  MSM  Green Tea  Boswellia  Fucoxanthin  Tumeric  Chromium  Ginger  Cinnamon  Alpha Lipoic Acid  Berberine  Magnesium  Red Yeast Rice  Garlic  Bergamonte  Co Enzyme Q10  Acetyl L Carnitine  Reservetrol  N Acetyle Cysteine  Melatonin  Glucosamine  B12  Chondroitin

 Safety – supplements can interact with prescription medications and can cause side effects  Research the company – do they do 3rd party testing of their product?  Quality – you get what you pay for. Testing is expensive and will be reflected in the price.  Be aware - your doctor may not know a lot about supplements or interactions.  Tropical fruit  Appears to block an enzyme called citrate lyase which your body uses to make fat  May also have an affect on glucose and cholesterol levels  Potential side effects: dizziness, dry mouth, headache, upset stomach, diarrhea  Cautions: Leukotriene inhibitors (Singulair, Accolate), Diabetes meds that can cause hypoglycemia, Statin cholesterol meds, Blood thinners  Dosing: 100 – 500mg 3 times/day with meals  Polyphenols play a role in the ecology of most plants. Typically found in the leaf, bark, flower or fruits of plants  EGCG is the major polyphenol in green tea and may increase resting metabolic rate and fat burning  It may also improve insulin resistance and cholesterol, and have antioxidant effects  Potential side effects: dizziness, insomnia, agitation, fatigue  Cautions: blood thinners, Diabetes meds that can cause hypoglycemia  Dosing: 100 – 750 mg daily (in divided doses)  Found in wakame (edible brown seaweed)  May increase metabolism and fat oxidation  May reduce blood sugar and improve insulin resistance  Potential side effects: none known  Cautions: no known drug interactions, caution with diabetes meds that can cause hypoglycemia  Dosing: 300mg twice/day  Is a mineral essential for proper glucose metabolism and with insulin function  May help with cholesterol  Potential side effects: headache, sleep disturbance, mood changes  Cautions: may inhibit thyroid medication absorption, caution with diabetes medications that can cause hypoglycemia  Dosing: 200 mcg 1-3 times/day  Potential benefits for healthy glucose metabolism  Potential side effects: none known  Cautions: no drug interactions known, caution with diabetes medications that can cause hypoglycemia  Dosing: 1-3 grams/day (1 gram = 1/4 -1/2 tsp)  Is a chemical found in the bark, roots and stems of plants including Oregon grape, Barberry, Tree Tumeric, Goldenseal and Yellowroot  Can lower a1c, glucose, insulin and cholesterol  Potential side effects: headache, nausea, vomiting, bloating  Cautions: AVOID if taking Cyclosporine. Caution with diabetes meds that can cause hypoglycemia  Dosing: 350 – 500mg 2-3 times/day  Is made from yeast grown on rice  Dietary staple in some Asian countries  Contains compounds called monacolins that block the production of cholesterol. May also affect blood sugar.  Cautions: blood thinners, diabetes medications that can cause hypoglycemia  AVOID TAKING WITH STATIN MEDS  Patients intolerant of statins may get similar reactions with red yeast rice  Dosing: 1200mg twice/day

 Extract of the Bergomot fruit, a bitter citrus fruit found in Southern Italy. Is commonly used as a flavoring in Earl Grey tea  May reduce cholesterol, raise HDL (good cholesterol), remove fatty deposits in the liver and lower blood sugar.  Potential side effects: rare cases of GI upset, nausea, increased gas, diarrhea, constipation  Cautions: no know interactions, but caution with using other cholesterol meds  Dosing: 1000 – 2000mg daily

 Amino acid derivative that plays a vital role in helping the body turn fat into energy  Can have benefits for cholesterol, Diabetes, neuropathy, chronic fatigue, Alzheimer’s  Potential side effects: GI upset, nausea, vomiting  Cautions: AVOID if history of seizures, may interfere with thyroid hormone meds  Dosing: 1000 – 3000mg daily in divided doses

 Form of the amino acid cysteine that is found in high protein foods  Can have benefits for COPD, cholesterol, chronic pain, OCD. Many other uses.  Potential side effects: nausea, vomiting, diarrhea, constipation  Cautions: can increase the effects of nitroglycerine. Potential concerns for triggering bronchospasm in asthma. Caution with blood thinners. Potential risk for cysteine kidney stones in prone patients  Dosing: 500 – 1000mg twice/day  Take Vitamin C 500 – 1500mg/day to reduce risk for stones  Is produced naturally by the body to help build cartilage  May stimulate the production of healthy, new cartilage  Best known for treating joint pain and increasing mobility in people with osteoarthritis, esp of the knee.  Potential side effects: nausea, diarrhea, bloating, headache  Cautions: caution with blood thinners and with asthma  Dosing: 1500 – 3000mg daily in divided doses  Often found in combo with Chondroitin and MSM  Substance that makes the cartilage in your joints resilient. One of the basic building blocks of most connective tissues  May help pain and joint stiffness of osteoarthritis, esp of the knee  Potential side effects: rare nausea, bloating, diarrhea  Cautions: may interact with blood thinners  Dosing: 1200mg daily in divided doses  Chemical found in plants, animals and humans  May benefit joint pains and arthritis, esp of the knee  Potential side effects: nausea, diarrhea, bloating, headache, insomnia  Cautions: no known interactions  Dosing: 1500mg daily in divided doses  The boswellia tree is a flowering plant native to regions of Africa and Asia.  The biblical incense frankincense is made of resin from the boswellia tree  Appears to have anti inflammatory properties by inhibiting enzymes called leukotrienes that contribute to inflammation and pain.  Can have benefits for arthritis, bursitis, tendonitis, rheumatoid arthritis. Has also been researches in Crohn’s and Ulcerative Colitis.  Potential side effects: rare diarrhea, skin rash, nausea, acid reflux  Cautions: may interact with certain asthma / allergy meds called Leukotriene inhibitors (Singulair, Accolate)  Dosing: 150 – 400mg 3 times/day, take with a fatty meal  Best known as a spice. Is one of the main components of curry  Has anti inflammatory and anti oxidant properties  May benefit joint pain, arthritis, chronic pain, depression  Potential side effects: nausea, diarrhea, increased bleeding  Cautions: may interact with blood thinners  Dosing: 500 – 2000mg daily in divided doses  Has been used to treat nausea, motion sickness and arthritis pain. May potentially lower blood sugar  Has anti inflammatory properties  Potential side effects: rare  Cautions: high doses could interfere with cardiac, diabetes and blood thinning meds  Dosing: 1000 – 4000mg daily divided into 2-4 doses  Is a fatty acid that is essential to the body’s production of energy  Is an anti oxidant found in most foods, esp. kidney, liver, spinach, broccoli and yeast extract  May have benefit in glucose/insulin function, diabetic neuropathy and chronic fatigue  Potential side effects: rare  Cautions: no known drug interactions. Caution if taking diabetes meds that can cause hypoglycemia  Dosing: 50-100mg daily, but can take up to 1800mg daily  Is a mineral that plays a role in over 300 enzyme reactions  Foods high in magnesium include spinach, broccoli, sunflower seeds, almonds, sesame seeds, cashews, peanut butter, beans, peas, edemame  Can help with migraines, insomnia, palpitations, muscle cramps (esp. nocturnal leg cramps)  Is available in different forms: Magnesium citrate, Magnesium gluconate, Magnesium glycinate, Magnesium lactate  Potential side effects: GI upset, diarrhea  Cautions: is excreted in the kidneys so caution with chronic kidney disease; do not take with amiloride (heart medication); may increase absorption of some diabetes meds (esp Glipizide, Glyburide); hold if also taking any of the following antibiotics (Ciprofloxin, Avelox, Tetracycline, Doxycycline, Minocycline)  Dosing: 120 – 500mg daily  Has enzymes that can reduce cholesterol, blood pressure and platelet adhesion (clot formation) resulting in improved heart health  Potential benefits for reducing coronary artery calcifications/plaque, lowering BP  Potential side effects: GI upset, body odor, bad breath  Cautions: blood thinners  Dosing: 1 clove daily, 2400mg daily  Improves the production of energy in cells  Is an anti oxidant  Can have benefits for CHF, blood pressure, cholesterol, side effects of statin medications (may reduce levels of CoQ10 in the body) and fibromyalgia  Potential side effects: rare  Cautions: blood thinners  Dosing: 100 – 300mg daily divided 2-3 times/day  A substance found in red wine, grapes, blueberries, raspberries, mulberries  Potential heart protection effects – blood vessel dilator, prevent blood clots.  Is also has anti oxidant and anti inflammatory properties.  Potential side effects: rare  Cautions: blood thinners; women on estrogen therapy (can have some possible estrogen like affects)  Dosing: 20-60 mg daily divided into 2 doses  Is a natural hormone produced by the pineal gland in the brain to regulate sleep  Levels are suppressed during the day in response to sunlight, then rise at night to trigger sleep  Has anti oxidant properties at higher doses  Helpful for insomnia, sleep disturbances due to jet lag and shift work; may help with Chronic Fatigue Syndrome and Irritable Bowel Syndrome  Potential side effects: drowsiness, GI discomfort, morning grogginess  Cautions: may interact with Prozac (Fluoxetine); may increase the effects of sedating meds (Benzodiazepines and anti histamines)  Dosing: 0.5 – 10 mg at bedtime  Is essential for red blood cell production, healthy nerves, producing DNA  Is not found in plant sources. Common food sources – beef, cheese, liver, eggs, salmon, sardines, trout, tuna  Risks for deficiency: vegetarians, Metformin use, use of stomach acid medications, colchicine  Potential side effects: none common  No concerning interactions  Dosing: 500-1000mcg daily. Available in oral, injection and nasal (Nascobol) forms  Taking Vitamin C with B12 can increase improve its absorption