CV

PAOLO ZAMBONI, MD

Coordinates: Prof. Paolo Zamboni, Chair of Vascular Surgery, Department of Translational Medicine and for Romagna, University of , Arcispedale Sant’Anna, Via Aldo Moro 8, 44124 Loc. Cona, Ferrara. Tel. +39 0532 237694, 236524, e-mail: [email protected]

BIOGRAPHICAL SKETCH Paolo Zamboni, MD

NAME POSITION TITLE Paolo Zamboni, MD Full Professor, Chair of Vascular Surgery

EDUCATION/TRAINING

DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY

University of Ferrara, M.D. 1982 Medicine General and Vascular Arcispedale S. Anna, Ferrara, Italy Residency 1982-1987 Surgery

A. Positions and Employment (chronological order) 1986 Fellow, Division of Vascular Surgery, University of California, San Francisco, California, USA 1990 Visiting Professorship Transplantation, University of California, San Francisco, California, USA 1992 Specialty, in Vascular Surgery, University of Ferrara, Italy 1987-1992 Assistant Professor, Istituto di Patologia, Chirurgica, University of Sassari, Italy 1992-2005 Assistant Professor, Istituto di Chirurgia Generale, University of Ferrara, Italy 1993-1995 Distinguished Visiting Professorship U.S.H.U.S. Bethesda, Maryland, USA 2004-Present Director, Vascular Diseases Center, University of Ferrara, Italy 2016-Present Full Professor, Chair of Vascular Surgery, University of Ferrara, Italy 2017-Present Program Director Residency in Vascular Surgery, University of Ferrara, Italy 2018-Present Chair Hub Center Venous and Lymphatic Diseases Emilia e Romagna Region, Italy

Other Experience and Professional Memberships 1992 Visiting Professorship at University California, San Francisco, California, USA 1993-1995 Distinguished Professorship USHUS, Bethesda, Maryland, USA 1994-present Member American Venous Forum 2001 Founding Member European Venous Forum 2006-present Member Royal Society of Medicine, London 2008 Grand Rounds, State University New York, Buffalo, New York, USA 2009 Invited Professorship at , Boston, Massachusetts, USA 2010 Invited Professorship at New York University, New York, USA 2010 Founding Member International Society for Neurovascular Diseases. 2010-2011 President, International Society for Neurovascular Disease (ISNVD) 2012 Grand Rounds , Illinois, USA 2010 Honorary Fellow Australasian College of Phlebology 2010-2011 President International Society for Neurovascular Diseases 2018-present Italian College of Academic Professors of Vascular Surgery

Honors • International Glauco Bassi Award Venous and Lymphatic disorders, 1998, 2000, 2003 • American Venous Forum Award, 2002, 2005, 2007 • Scientific Prize European Venous Forum, 2002, 2005 • Prize Gian Camillo Donadi, Collegio Italiano di Flebologia, 2003 • Gold Medal Award 2015, International Society for Neurovascular Diseases • Annette Funicello Foundation Award 2016 • San Giorgio Gratitude Award of the Town of Ferrara, Italy, 2016 • Commander of the Italian Republic for Scientific Merit, 2017

B. Publications in peer review journals He is Author of 294 international publications. Citations number 12938, H-Index 52, i10-index 172. The complete list of publications with related number of citations can be found on Google Scholar, Paolo Zamboni public profile: https://scholar.google.com/citations?user=3AkMjFkAAAAJ&hl=it&oi=ao

C. Textbooks -C. Franceschi e P. Zamboni Editors. Principles of Venous Haemodynamics. Nova Science New York 2007. -Alessia Giaquinta, B.B. Lee, Carlo Setacci, Pierfrancesco Veroux and Paolo Zamboni Editors. From anatomy to function of large veins. Minerva Medica International, Torino, 2018. - P. Zamboni, S. Gianesini, E. Mendoza. Saphenous Vein-Sparing Strategies in Chronic Venous Disease. Springer, 2018

D. Competitive Peer Review Grants

• PI Italian Ministry of Health project 2015-2017 • PI Drain Brain space project ASI-ESA-NASA 2013-2015 • PI Telemedicine Project European Space Agency 2015-2016 • Coordinator of Research projects of National interest, Ministry of University, 2001, 2004, 2010, 2013 • PI multicentric RCT trial NCT01371760 clinicaltrials.gov 2012-2015 • Co-PI Transantlantic cooperation with Jacobs Institute of Neurology and Buffalo Neuroimaging Analysis Center SUNY Buffalo, NY USA. 2009-2010 (CVI-MS Chronic venous insufficiency in . A haemodynamic pilot study of cerebrospinal venous drainage using non- conventional mri measures and sonography). • Co-PI Transantlantic cooperation with Jacobs Institute of Neurology and Buffalo Neuroimaging Analysis Center SUNY Buffalo, NY USA. 2009-2010 (EVT-MS Endovascular Treatment for Multiple Sclerosis). • Grant Marie Curie European Commission MeDiTATe project Medical Digital Twin for Aneurysm Prevention and Treatment. 2019-2022

E. PhD Programs

• 2012-2015 Scientific Board PhD School in Biomedical Sciences, University of Ferrara, Italy • 2016-present Scientific Board PhD School in Neurosciences and Neurotechnology, Italian Institute of Technology and University of Ferrara, Italy

F. International Committee, Guidelines, Editorial Activity

• Guidelines. Diagnosis and treatment of venous malformations. consensus document of the International Union of Phlebology (IUP): updated-2013. Int Angiol. 2015 Apr;34(2):97-149. • International Society for Neurovascular Disease. Recommendations for multimodal noninvasive and invasive screening for detection of extracranial venous abnormalities indicative of chronic

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page cerebrospinal venous insufficiency: a position statement of the International Society for Neurovascular Disease. J Vasc Interv Radiol. 2014 Nov;25(11):1785-94. • Society for Vascular Surgery and American Venous Forum Guidelines on the management of venous leg ulcers. Int Angiol. 2015 Jun;34(3):202-18. • Venous hemodynamic changes: the UIP consensus according to scientific evidence. Int Angiol. 2016 Jun;35(3):236-352. • Editor in Chief Veins and Lymphatics, 2017

G. Patent Intellectual Property -Paolo Zamboni. WO/2009/107152. SYSTEM FOR DIAGNOSING MULTIPLE SCLEROSIS. Unife transferred the patent to LONDON EQUITABLE LIMITED IN ITS CAPACITY AS TRUSTEE OF THE THINK TANK TRUST. PCT/IT2008/000129. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009107152 -Zamboni P, Manfredini F. Device for pneumatic treatment of an inferior limb having peripheral arteriopathy problem (Gradient pump). Publication number: WO2010004592 (A1). Unife transferred the patent to LONDON EQUITABLE LIMITED IN ITS CAPACITY AS TRUSTEE OFTHE THINK TANK TRUST. PCT/IT2008/000454 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO201 0004592 -Zamboni P, Gemmati D. WO2009125296 (A2) - GENETIC MARKERS OF WOUNDDEVELOPMENT . PCT/IB2009/005381. transferred the patent to SYSTAGENIX WOUND MAN IP CO B V [NL]. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009125296 -Gemmati D, Zamboni P. WO2009125295 (A2) - GENETIC MARKERS OF VASCULAR WOUND DEVELOPMENT PCT/IB2009/005371. transferred the patent to SYSTAGENIX WOUND MAN IP CO B V [NL].https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2009125295 -FERLINI A., ZAMBONI P. WO/2011/027292. Array-based method for detection of Copy number variations in the HLA locus for the genetic determination of susceptibility of development of venous malformations in the extracranial segments of the cerebrospinal veins and kit thereof. Numero domanda: PTC/IB2010/053901. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2011027292 - Paolo Zamboni. US20120191727 A1. System for detecting extra cranial venous flow anomalies. Numero domanda: US 13/390,141. http://appft1.uspto.gov/netacgi/nph-Pa rser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f= G&l=5 0&s1=20120191727.PGNR • Zamboni Paolo. WO/2012/123785 GENE POLYMORPHISMS IN MULTIPLE SCLEROSIS. PCT/IB2011/051032, Università degli Studi di Ferrara. https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012123785 -Paolo Zamboni, Francesco Sisini. Software Registration Assessment of Cerebral Outflow N. 008412 del 31-5-2012, Università di Ferrara . -Paolo Zamboni e Francesco Sisini. Software Registration JVP rapid ultrasonographic assessment of the jugular pulse, Cod. 009393 del 10-10-2014, Università di Ferrara

H. Main Scientific Publications

1. Zamboni P. COVID-19 as a : Lesson Learned from Imaging and Blood Biomarkers. Diagnostics (Basel). 2020 Jun 29;10(7):440. doi: 10.3390/diagnostics10070440 IF: 3.129 2. Zamboni P, Galeotti R, Salvi F, Giaquinta A, Setacci C, Alborino S, Guzzardi G, Sclafani SJ, Maietti E, Veroux P; Brave Dreams Research Group. Effects of Venous Angioplasty on Cerebral Lesions in Multiple

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Sclerosis: Expanded Analysis of the Brave Dreams Double-Blind, Sham-Controlled Randomized Trial. J Endovasc Ther. 2020 Feb;27(1):1526602819890110. doi: 10.1177/1526602819890110. IF: 3.111 3. Zamboni P, Tesio L, Galimberti S, Massacesi L, Salvi F, D'Alessandro R, Cenni P, Galeotti R, Papini D, D'Amico R, Simi S, Valsecchi MG, Filippini G; Brave Dreams Research Group. Efficacy and Safety of Extracranial Vein Angioplasty in Multiple Sclerosis: A Randomized Clinical Trial. JAMA Neurol. 2017 Nov 18. doi: 10.1001/jamaneurol.2017.3825. IF: 10.029 4. Sisini Francesco, Tessari Mirko, Menegatti Erica, Vannini Maria Elena, Gianesini Sergio, Tavoni Valentina, Gadda Giacomo, Gambaccini Mauro, Taibi Angelo, Zamboni Paolo. Clinical Applicability of Assessment of Jugular Flow over the Individual Cardiac Cycle Compared with Current Ultrasound Methodology. Ultrasound In Medicine And Biology 2016, vol. 42, p. 1750-63-1763. IF: 2.494. 5. Zivadinov R, Magnano C, Galeotti R, Schirda C, Menegatti E, Weinstock-Guttman B, Marr K, Bartolomei I, Hagemeier J, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Beggs C, Salvi F, Zamboni P. Changes of cine cerebrospinal fluid dynamics in patients with multiple sclerosis treated with percutaneous transluminal angioplasty: a case-control study. Journal Of Vascular And Interventional Radiology 2013, vol. 24, p. 829-838. IF: 2.780 6. Zamboni P, Menegatti E, Conforti P, Shepherd S, Tessari M, Beggs C. Assessment of cerebral venous return by a novel plethysmography method. Journal Of Vascular Surgery 2012, vol. 20, p. 677-685. IF: 3.536. 7. Zamboni P, Menegatti E, Pomidori L, Morovic S, Taibi A, Malagoni AM, Cogo AL, Gambaccini M. Does thoracic pump influence the cerebral venous return? J Appl Physiol (1985). 2012 Mar;112(5):904-10. IF: 3.351. 8. Zamboni P, Galeotti R, Weinstock-Guttman B, Kennedy C, Salvi F, Zivadinov R. Venous angioplasty in patients with multiple sclerosis: results of a pilot study. Eur J Vasc Endovasc Surg. 2012 Jan;43(1):116- 22. IF: 4.061 9. Zamboni P, Menegatti E, Weinstock-Guttman B, Dwyer MG, Schirda CV, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Bergsland N, Magnano C, Bartolomei I, Salvi F, Zivadinov R. Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report. BMC Med. 2011 Mar 7;9:22. IF: 8.097. 10. Zivadinov R, Galeotti R, Hojnacki D, Menegatti E, Dwyer MG, Schirda C, Malagoni AM, Marr K, Kennedy C, Bartolomei I, Magnano C, Salvi F, Weinstock-Guttman B, Zamboni P. Value of MR venography for detection of internal jugular vein anomalies in multiple sclerosis: a pilot longitudinal study. AJNR Am J Neuroradiol. 2011 May;32(5):938-46. IF: 3.550. 11. Zamboni P. Can Facebook influence funding? Nature. 2011 May 26;473(7348):452. doi: 10.1038/473452e. IF: 42.778 12. Zamboni P, Gianesini S, Menegatti E, Tacconi G, Palazzo A, Liboni A. Great saphenous varicose vein surgery without saphenofemoral junction disconnection. Br J Surg. 2010 Jun;97(6):820-5. IF: 5.899. CIT: 39 13. Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'Ara S, Bartolomei I, Salvi F. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):392-9. IF: 7.349 14. Manfredini F, Malagoni AM, Felisatti M, Mandini S, Mascoli F, Manfredini R, Basaglia N, Zamboni P. A dynamic objective evaluation of peripheral arterial disease by Near-Infrared Spectroscopy. European Journal Of Vascular And Endovascular Surgery 2009, vol. 38, p. 441-448. IF: 4.061 15. Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Gianesini S, Bartolomei I, Mascoli F, Salvi F. A prospective open-label study of endovascular treatment of chronic cerebrospinal venous insufficiency. J Vasc Surg. 2009 Dec;50(6):1348-58.e1-3. IF: 3.536.

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page 16. Singh AV, Zamboni P. Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab. 2009 Dec;29(12):1867-78. IF: 5.081. 17. Zamboni P, Consorti G, Galeotti R, Gianesini S, Menegatti E, Tacconi G, Carinci F. Venous collateral circulation of the extracranial cerebrospinal outflow routes. Curr Neurovasc Res. 2009 Aug;6(3):204-12. IF: 2.298. 18. Carandina S, Mari C, De Palma M, Marcellino MG, Cisno C, Legnaro A, Liboni A, Zamboni P. Varicose vein stripping vs haemodynamic correction (CHIVA): a long term randomised trial. Eur J Vasc Endovasc Surg. 2008 Feb;35(2):230-7. IF: 4.061 19. F. Manfredini, A.M. Malagoni, F. Mascoli, S. Mandini, M. C. Taddia, N. Basaglia, R. Manfredini, F. Conconi, P. Zamboni. Training rather than walking: the test in-train out program for home-based rehabilitation in peripheral arteriopathy. Circulation Journal 2008, vol. 72, p. 946-952. IF: 3.544. 20. Zamboni P, Tognazzo S, Izzo M, Pancaldi F, Scapoli GL, Liboni A, Gemmati D. Hemochromatosis C282Y gene mutation increases the risk of venous leg ulceration. J Vasc Surg. 2005 Aug;42(2):309-14. IF: 3.536. 21. Zamboni P, Cisno C, Marchetti F, Mazza P, Fogato L, Carandina S, De Palma M, Liboni A. Minimally invasive surgical management of primary venous ulcers vs. compression treatment: a randomized clinical trial. Eur J Vasc Endovasc Surg. 2003 Apr;25(4):313-8. Erratum in: Eur J Vasc Endovasc Surg. 2003 Sep;26(3):337-8. IF: 4.061 22. Zamboni P, Cisno C, Marchetti F, Quaglio D, Mazza P, Liboni A. Reflux elimination without any ablation or disconnection of the saphenous vein. A haemodynamic model for venous surgery. Eur J Vasc Endovasc Surg. 2001 Apr;21(4):361-9. IF: 4.061 23. Manfredini R, Portaluppi F, Zamboni P, Salmi R, Gallerani M. Circadian variation in spontaneous rupture of abdominal aorta. Lancet. 1999 Feb 20;353(9153):643-4. IF: 47.831.

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