Center for Center &Nanoscience Nanotechnology Tel Aviv University SCIENTIFIC REPORT 2015–2016 REPORT SCIENTIFIC Nanoscience
Nanotechnology
The Center for for Center The &
The Center for Nanoscience and Nanotechnology Scientific Report 2015–2016 Tel Aviv University Center for Nanoscience & Nanotechnology Powering Innovation Center for Nanoscience & Nanotechnology Tel Aviv University
Center for Nanoscience & Nanotechnology
SCIENTIFIC REPORT May 2016
Tel Aviv University Center for Nanoscience & Nanotechnology Powering Innovation
Contents
Overview...... 6
Hubs of Innovation...... 7 The Micro & Nano Characterization & Fabrication Facility (MNCF)...... 7 XIN Center...... 7
Educational Activities...... 8 International Summer School on Nanomedicine, Tel Aviv University...... 8 Autumn Innovation Forum, Beijing...... 8 Winter School on Nano-Photonics, Tel Aviv University...... 8 The Fred Chaoul TAU 10th Annual Nano Workshop, Hagoshrim ...... 9 XIN Winter School on Physics at the Edge:, Tel Aviv University...... 9 XIN Autumn Innovation Forum, Tsinghua University, Beijing...... 9 IEEE–Gertner Summer School on Nanomedicine, Tel Aviv University...... 9 Intersecting Pathways ...... 9 School Visits...... 9
A New Building for Tel Aviv University’s Center for Nanoscience & Nanotechnology ...... 10
Researchers...... 11 Dr. David Sprinzak...... 13 Prof. Alexander Kotlyar...... 14 Dr. Iftach Nachman...... 15 Prof. Abdussalam Azem...... 16 Prof. Karen B. Avraham...... 17 Prof. Uri Ashery...... 18 Prof. Itai Benhar...... 19 Dr. Noam Shomron...... 21 Dr. Avigdor Eldar...... 22 Prof. Roy Beck...... 23 Dr. Yael Roichman...... 24 Dr. Yair Shokef...... 25 Prof. Tamir Tuller...... 26 Dr. Sharly Fleischer...... 27 Prof. Eli Eisenberg...... 28 Dr. Amir Goldbourt...... 29 Prof. David Andelman...... 30 Prof. Natan Shaked...... 31 Prof. Yael Hanein...... 32
3 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY CENTER FOR NANOSCIENCE & NANOTECHNOLOGY
Prof. Slava Krylov...... 33 Prof. Gil Rosenman...... 34 Dr. Yuval Ebenstein...... 35 Prof. Yosi Shacham...... 36 Prof. Shachar Richter...... 37 Prof. Michael Gozin...... 38 Prof. Chanoch Carmeli...... 39 Prof. Yossi Rosenwaks...... 40 Dr. Tal Dvir...... 41 Dr. Alexander Golberg...... 42 Prof. Judith Rishpon...... 43 Prof. Noam Eliaz...... 44 Dr. Oswaldo Dieguez...... 45 Prof. Oded Hod...... 46 Dr. Amir Natan...... 47 Prof. Michael Urbakh...... 48 Prof. Haim Diamant...... 50 Prof. Diana Golodnitsky ...... 51 Prof. Gil Markovich...... 52 Prof. Ori Cheshnovsky...... 53 Prof. Emanuel Peled...... 54 Prof. Abraham Nitzan...... 55 Dr. Roey J. Amir...... 56 Prof. Dan Peer...... 57 Prof. Ronit Satchi-Fainaro...... 58 Prof. Inna Slutsky...... 59 Prof. Rimona Margalit...... 60 Prof. Ehud Gazit...... 61 Dr. Tal Ellenbogen...... 62 Prof. Jacob Scheuer...... 63 Dr. Yossi Lereah...... 64 Dr. Alon Bahabad...... 65 Prof. David J. Bergman...... 66 Prof. Ady Arie...... 67 Prof. Amir Boag...... 68 Dr. Moshe Goldstein...... 69
4 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY SCIENTIFIC REPORT 2015–2016
Prof. Yoram Dagan...... 70 Prof. Alexander Gerber...... 71 Dr. Guy Cohen...... 72 Prof. Alexander Palevski...... 73 Prof. Ilan Goldfarb...... 74
Publications...... 77
Spinoffs ...... 89 Startups...... 89 License Agreements...... 89
Staff ...... 91
Acknowledgments...... 93
Scholarships...... 94
5 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY CENTER FOR NANOSCIENCE & NANOTECHNOLOGY
Overview
Tel Aviv University’s Center for Nanoscience & Nanotechnology was established in 2000, as the first Israeli center of its kind. Since then we have expanded and grown significantly: today the Center is affiliated with over 90 research groups, employs its own professional staff of researchers and scientists, and runs a state-of-the-art central facility.
Tel Aviv University’s Center for Nanoscience & Nanotechnology was a pioneer and leader in setting up a multidisciplinary environment, where laboratories from entirely different domains work side by side under one roof. In addition, through the synergy established between these laboratories and the Center’s Micro- and Nanofabrication Facility, a unique, campus-wide activity was created, generating a multitude of unique projects. Over the years we have also strengthened our ties with industry, providing extensive services to a growing number of companies - from small startups to large corporations.
Today, with 16 years of constant growth behind it, the Center has positioned itself as an important asset to Tel Aviv University’s researchers and the Israeli industry.
We hope you will find the information in this publication useful for identifying new partnerships, resources and ideas. Comprehensive and constantly updated information about the Center is available on our website at www.nano.tau.ac.il.
6 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY SCIENTIFIC REPORT 2015–2016
Hubs of Innovation
The Micro & Nano Characterization & Fabrication Facility (MNCF)
Tel Aviv University’s Micro & Nano Characterization & Fabrication Laboratories are the leading facilities of their kind in Israel, with regard to providing services to both academia and industry. More than 50 academic groups and over 40 companies currently use the Laboratories - which are managed by a professional team, and offer outstanding infrastructures (thanks to a multimillion dollar investment by both the Israeli government and TAU). The Laboratories provide R&D services to large Israeli corporations, as well as Since 2007, we have established standardized training routines small startups in their earliest stages. for students, local scientists and external users. We continue our effort to film training sessions on specific machines in collaboration with TEMPUS.
XIN Center In 2014 the elite Chinese University, Tsinghua of Beijing (THU), teamed with Tel Aviv University to launch XIN Center, a joint venture aiming to power innovation via ties between top Chinese and Israeli researchers in the fields of Nanoscience and Nanotechnology.
The XIN (meaning New in Chinese) Center focuses on The TAU Center’s equipment is among the most advanced collaborative, high-impact applied research, promoting and comprehensive in Israel, spanning all types of fabrication over a dozen applied research programs of TAU and THU. methods, and enabling the development of full-process A unique mentoring system is applied, whereby leading prototypes. Capabilities and technologies at the Labs include scientists, industrialists and business figures accompany mask design and fabrication, optical lithography and e-beam projects throughout all stages of research, combining lithography, and advanced backend techniques such as wire internal and external resources from both Israel and China. bonding and dicing. Our new laser-cutting and machining system is the first of its kind in Israel. The Labs’ process engineers offer researchers and corporations comprehensive prototype development services, from small-scale predefined runs to large R&D projects and full-process development, conducted jointly with the customer. Services - including characterization, device design, mask preparation, sample fabrication and backend – are continually improved and expanded, as we add standard operating procedures of more systems, and offer them online. Most of the equipment managed by MNCF is housed in two buildings, and all equipment and personnel are managed by a single financial and administrative entity.
7 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY CENTER FOR NANOSCIENCE & NANOTECHNOLOGY
Emphasis is placed on co-projects conducted jointly by small molecules for treating Parkinson’s disease (Prof. Danny researchers from both universities. Current examples include: Segal & Prof. Yan-Mei Li). Over a dozen PhD students from diagnostics and prognosis of cancer and other diseases using both universities have already participated in exchange visits the CRISPR system (Dr. Yuval Ebenstein, Prof. Ting Zhu); and facilitating research in the field of nanotechnology.
Educational Activities
The Center for Nanoscience & Nanotechnology organizes a path to commercialization. The School was organized by range of social and scientific activities, including an annual Prof. Dan Peer, Dr. Artium Khatchtouriants, Dr. Inbal Hazan- workshop, monthly seminars, monthly “Nano-Beer” events, Hallevy, Prof. Karen Avraham and Prof. Yael Hanein. student exchange programs and more. Over the past two years, major activities have included: Autumn Innovation Forum, October 2014, Tsinghua University, Beijing XIN Center, a joint initiative of Tel Aviv University and Tsinghua University, conducted its 2014 Autumn Forum in Beijing, China. Top academics and students from both universities, as well as entrepreneurs, investors and major government, business and industry leaders from China and Israel, joined together to discuss the universities’ new initiatives in the nano-field. Dozens of early-stage technologies originating from both universities were evaluated, and the most promising among them were selected for further development, to be conducted under the XIN Center. Additionally, collaborations between researchers and student exchanges were initiated.
Winter School on Nano-Photonics, International Summer School on February 2015, Tel Aviv University Nanomedicine, June 2014, Over a hundred students and lecturers from Tel Aviv University, Tel Aviv University Tsinghua University and other Israeli and international universities - including Prof. John Pendry from Imperial College About 100 participants, including over 40 international and Prof. Nader Engheta from the University of Pennsylvania - students, presented and discussed their novel research in took part in this special event. Novel topics in nano-photonics nanomedicine. were presented and discussed, including: transformation optics, meta-materials & meta-surfaces, nano-antennas and Lectures were given on the following topics: RNAi delivery, plasmonics, quantum dots, beam shaping and nano-imaging. nano-diagnostics, nano-neuro interfaces, nanotechnologies The Winter School was organized by Prof. Adi Arie and Dr. for regenerative medicine and tissue engineering and the Koby Scheuer.
8 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY SCIENTIFIC REPORT 2015–2016
The Fred Chaoul TAU 10th Annual IEEE–Gertner Summer School on Nano Workshop, February 2015, Nanomedicine, June 2016, Hagoshrim Tel Aviv University
Over one hundred of Tel Aviv University’s nanotechnology The TAU Center for Nanoscience & Nanotechnology is the students and lecturers presented their recent research proud winner of the first ever Summer School grant from activities and enjoyed a range of social gatherings during this IEEE Nano. The special Summer School for graduate students, 3-day Workshop. Prof. Miles Padgett (University of Glasgow) also supported by a generous donation from the Gertner gave a guest lecture on shaping light for imaging and sensing. Institute, offers intensive training in nanomedicine. The The Workshop was organized by Dr. Tal Dvir, Dr. Tal Schwartz School’s organizers are Prof. Yael Hanein, Prof. Dan Peer and and Dr. Tal Ellenbogen. Dr. Tal Dvir.
XIN Winter School on Physics at the Intersecting Pathways Edge: from Topological Surfaces In 2014 Tel Aviv University’s Center for Nanoscience & to Oxide Interfaces, January 2016, Nanotechnology and the Amit Foundation established the Tel Aviv University Intersecting Pathways project, bringing together outstanding Torah scholars and top academic scientists for a joint learning About 80 lecturers and students from Israel and abroad experience on Science & Ethics. The project builds a unique participated in the Winter School, which included intensive and surprising bond that facilitates curiosity, friendship and training by internationally renowned scientists – such as scholarship. Over 20 such meetings have already taken place, Prof. Qikun Xue (Tsinghua University), Prof. Aharon Kapitulnik attracting more than 40 frequent attendees. (Stanford), Prof. Gabriel Aeppli (ETH), Prof. Yulin Chen (Oxford) and Prof. Yoram Dagan (TAU). Topological surfaces and School Visits oxide interfaces are an emerging scientific field, with great significance for both basic and applied research. The School The Nano Center regularly hosts and guides groups from was organized by Prof. Yoram Dagan and Dr. Moshe Goldstein. k-12 schools all over Israel, in order to enrich knowledge on nanotechnology and promote scientific excellence among XIN Autumn Innovation Forum, the country’s younger generation. At TAU’s advanced nano facilities our young guests view cutting-edge experiments October 2015, Tsinghua University, from the forefront of modern science. One especially popular Beijing demonstration is the preparation of a sensor for ionic materials, based on an aqueous colloidal solution of electro-stable Top academics and students from Tel Aviv and Tsinghua gold nanoparticles. Universities, alongside entrepreneurs, investors and major government, business and industry leaders from both China and Israel, joined together to discuss the universities’ new initiatives in the nano-field. Promising early-stage technologies introduced by the researchers were selected for further development, to be conducted under the XIN Center. Additionally, collaborations between researchers and student exchanges were initiated.
9 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY CENTER FOR NANOSCIENCE & NANOTECHNOLOGY
A New Building for Tel Aviv University’s Center for Nanoscience & Nanotechnology
To fulfill the growing needs of both the Center and Tel Aviv The new building will be constructed next to TAU’s Gate 2, University’s research community, a new Nano Building is forming a new entrance to the University. Accessible to the currently being planned. The modern building will house general public, it will invite visitors from the community to the Nano Characterization & Fabrication Laboratory (about experience cutting-edge science firsthand. A special space 600 m2), alongside 12 core research laboratories. Altogether, will be dedicated to collaboration between the Center’s about 120 engineers and researchers from academia and researchers and their guests from both academia and industry. industry will use the building as their main hub. The overall cost of the building is estimated at $30 M.
10 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS (sorted by theme of research)
RESEARCHERS
Dr. David Sprinzak
Affiliation: Life Sciences Email: [email protected] Web: http://www.sprinzaklab.com
Research Title Research Description Systems developmental biology The development of a multicellular organism is a truly fantastic process. How genetically identical cells Selected Publications: differentiate into distinct cell types in an accurate 1. Khait I, Orsher Y, Golan O, Binshtok U, Gordon-Bar N, Amir-Zilberstein L, and reproducible manner remains one of the most Sprinzak D. Quantitative Analysis of Delta-like 1 Membrane Dynamics important questions in biology. Elucidates the Role of Contact Geometry on Notch Signaling. Cell The long-term goal of our lab is to elucidate the Rep. 2015 Dec 30. design principles of complex developmental 2. Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, programs underlying organized differentiation Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau patterns. In particular, we are interested in: 1. How M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB. The the properties of intercellular signaling pathways GPSM2/LGN GoLoco motifs are essential for hearing. Mamm Genome. contribute to the development of tissues and organs; 2015 Dec 11. 2. How cellular mechanics and cellular morphology 3. Yaron T., Cordova Y., Sprinzak D. Juxtacrine Signaling Is Inherently affect, and are affected by, regulatory processes Noisy. Biophys. J. (2014) vol. 107, Issue 10, Pages 2417–2424. within cells and signaling between cells. 4. D. Sprinzak, A. Lakhanpal, L. LeBon, J. Garcia-Ojalvo, M. B. Elowitz. To address these questions we apply an Mutual inactivation of Notch receptors and ligands facilitates interdisciplinary approach combining synthetic developmental patterning PLoS Comput. Biol. 2011 Jun;7(6). biology, quantitative imaging techniques, 5. D. Sprinzak, A. Lakhanpal, L. LeBon, L. A. Santat, M. E. Fontes, G. A. micropatterning technology and mathematical Anderson, J. Garcia-Ojalvo, M. B. Elowitz. Cis interactions between models. Notch and Delta generate mutually exclusive signaling states, Nature. 2010 May 6;465(729).
13 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Alexander Kotlyar
Affiliation: Life Sciences Email: [email protected] Web: http://www.sashakot.com/
Research Title Research Description DNA-based nanotechnology The main goal of our work is to develop new conductive molecular nanowires based on G4-DNA Selected Publications: and complexes of DNA with metal nanoparticles. 1. Eidelshtein, G., Fardian-Melamed, N., Gutkin, V., Basmanov, D., Klinov, We have synthesized nanowires composed of single D., Rotem, D., Levi-Kalisman, Y., Porath, D. and Kotlyar, A. (2016). self-folded poly(G) strands of thousands of bases. Synthesis and Properties of Novel Silver Containing DNA Molecules. These G4-wires comprise a large number of stacked Advanced Materials (in press). guanine tetrads, providing better conditions for π 2. Eidelshtein, G., Kotlyar, A., Hashemi, M. and Gurevich, G. (2015). overlap compared to base-pairs of the canonical Aligned deposition and electrical measurements on single DNA double-stranded DNA. A high content of guanines, molecules. Nanotechnology 475102 (8pp). which have the lowest ionization potential among 3. Livshits, G.I., Stern, A., Rotem, D., Borovok, N., Eidelshtein, G., Migliore, DNA bases, also makes charge migration through the A., Penzo, E., Wind, S.J., Di Felice, R., Skourtis, S.S., Cuevas, J.C., Gurevich. DNA highly probable. Indeed, we have demonstrated L., Kotlyar, A.B., Porath and D. (2014). Long-range charge transport charge transport in G4-DNA molecules adsorbed in single G4-DNA molecules. Nature Nanotechnology 9, 1040-1046. in a mica substrate. Currents ranging from tens of 4. Livshits, G.I., Ghabboun, J., Borovok, N., Kotlyar, A.B. and Porath D. picoamperes to more than 100 pA were measured (2014). Comparative Electrostatic Force Microscopy of Tetra‐and on single G4-DNA molecules over distances ranging Intra‐molecular G4‐DNA. Advanced Materials 26, 4981–4985. from tens of nanometers to more than 100 nm. 5. Halamish, S., Eidelshtein, G. and Kotlyar, A. (2013) Plasmon-coupled These results could open a way to the realization nanostructures comprising finite number of gold particles. Plasmonics of nanoscale transistors and devices. 8, 745-748.
14 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Iftach Nachman
Affiliation: Life Sciences 4. Smith, Z.D., Nachman, I., Regev, A., Meissner, A. Email: [email protected] (2010). Dynamic single-cell imaging of direct Web: inachmanlab.com reprogramming reveals an early specifying event. Nature Biotechnol. May;28(5):521-6. 5. Yurkovsky, E., Nachman, I. (2013). Event timing Research Title at the single cell level. Brief Funct Genomics. Cell fate decisions in differentiation and reprogramming 12(2):90-8.
Selected Publications: Research Description 1. Goldshmidt, Y., Yurkovsky, E., Reif, A., Rosner, R., Akiva, A., Nachman, Our goal is to understand how cells within a I. (2015). Control of relative timing and stoichiometry by a master population reach developmental decisions at the regulator. PLoS One 10(5), e012733. phenotypic and mechanistic level: How do cells 2. Pour, M., Pilzer, I., Rosner, R., Smith, Z.D., Meissner, A., Nachman, I. “decide” to change their state? Why do similar (2015). Epigenetic predisposition to reprogramming fates in somatic cells respond differently to the same signal? What cells. EMBO reports 16, 370-378. properties of the cell’s internal state affect its 3. Aidelberg, G., Goldshmidt, Y., Nachman, I. (2012). A microfluidic decision? What determines these properties and device for studying multiple distinct strains. J Vis Exp, (69), e4257, their spread in the cell population? What determines doi:10.3791/4257. which cell states are stable? Our lab studies these
a c fundamental questions in two model systems, EB formation 3D Imaging 79h 87h 96h using methods from live cell fluorescent imaging,
EB microfluidics and statistical and computational Gene 55 expression profiling for analysis. each EB 100 m
b 73h 75h 79h 83.5h 57
100 m 66
m m 29 89.5h 94h 96h 98h
15
31
d e f g 3 3 35 90 2 30 2 85 1 25 1 80 20
0 Bry−GFP Total Points [K#] Bry−GFP Total Points [K#] Bry−GFP Total Points [K#] -20 -10 0 10 20 60 70 80 90 100 0 50 100 150 75 Time [Hours] Time [Hours] Time From Onset [Hours] 15 70 h i j 10 95 n=50, r=0.05 (p=0.76) 0.8 n=50, r=0.28 (p=0.05) 4 n=33, r=0.37 (p=0.03) 65 5 90 0.6 Onset time [Hours] 3 60 Onset to peak [Hours] 85 0 0.4 80 2 55 0.2 −5
75 Amplitude [K#]
Onset Slope [1/h] 50 Onset Time [Hours] Time Onset 70 0 1 80 130 180 80 130 180 80 115 150 1 2 3 1 2 3 EB Radius [um] EB Radius [um] EB Radius [um]
15 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Abdussalam Azem
Affiliation: Life Sciences Email: [email protected] Web: https://en-lifesci.tau.ac.il/profile/azema
Research Title mitochondrial membrane and the mitochondrial Molecular machines function matrix. The translocase of the inner membrane, TIM23 complex, with its associated proteins, is the Selected Publications: focus of one major project in our laboratory. 1. Demishtein-Zohary, K., Marom, M., Neupert, W., Mokranjac, D., The second main topic of our research is the Azem, A. (2015) GxxxG Motifs hold the TIM23 Complex Together. chaperonin family of proteins - the most well-known FEBS J. 282, 2178-2186. of which are the GroEL and GroES proteins of E. 2. Nisemblat, S., Yaniv, O., Parnas, A., Frolow, F., Azem, A. (2015). The coli. GroEL (cpn60 or Hsp60) binds with nascent crystal structure of the human mitochondrial chaperonin symmetric or stress-denatured proteins and facilitates their football complex. Proc. Natl. Acad. Sci. USA. 112, 6044-6049. refolding with the assistance of its co-chaperonin 3. Nisemblat, S., Parnas, A., Yaniv, O., Azem, A., Frolow, F. (2014) GroES (cpn10 or Hsp10). In mitochondria, Hsp60 Crystallization and structure determination of a symmetrical football mediates the folding of proteins that have been complex of the mammalian mitochondrial Hsp60-Hsp10 chaperonins. translocated from the cytosol to the matrix. The Acta Cryst. F. 70, 116-119. importance of these chaperonins in mitochondria 4. Sharabi, M., Mandelberg, Y., Benayahu, D., Benayahu, Y., Azem, A., has been heightened by the discovery of genetic Haj-Ali, R. (2014) A new class of bio-composite materials of unique diseases caused by mutations in these proteins, as collagen fibers. J. Mech. Behav. Biomed. Mater. 36C, 71-81. well as their extramitochondrial roles, some related 5. Marom, M, Azem, A and Mokranjac, D. (2011) Understanding to cancer development. the molecular mechanism of protein translocation across the Having studied the structure and function of mitochondrial inner membrane: Still a long way to go. Biochem. mitochondrial and chloroplast chaperonins in vitro Biophys. Acta (Biomembranes). 1808, 990-1001 for a long time, we recently became interested in the mechanism behind genetic diseases. Modern Research Description deep-sequencing technologies have facilitated the For many years, our laboratory has been interested primarily in unraveling identification of mutations responsible for recessive the molecular mechanisms behind the function of two groups of genetic diseases, and we use this information proteins: to delineate the molecular basis of the disease, The first is the sophisticated machinery that mitochondria use for applying a two-pronged approach. We utilize a translocating proteins from the cytosol. Most mitochondrial proteins yeast model to study the effects of the mutated are encoded in the nuclear genome, synthesized in the cytosol as protein in a biological system, while also producing preproteins and then imported into mitochondria. Uptake of these and purifying the mutated protein in vitro, in order preproteins into the mitochondria is mediated by a number of oligomeric to investigate its properties and its interaction with protein complexes, which are found in various places: the cytosol, other proteins. the outer mitochondrial membrane, intermembrane space, the inner
16 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Karen B. Avraham
Affiliation: Life Sciences Email: [email protected] Web: www.tau.ac.il/~karena
Research Title Research Description Genomics of hereditary hearing loss A major goal in auditory science is to understand how the cells of the inner ear develop to provide Selected Publications: the exquisite precision of hearing. The organ of 1. Shefer, S., Gordon, C., Avraham, K.B. and Mintz, M. (2015). Balance Corti, which houses the sensory cells of the inner deficit enhances anxiety and balance training decreases anxiety in ear, develops from sensory epithelium derived from vestibular mutant mice. Behav. Brain Res., 276:76-83. ectoderm. Together with innervation of the sensory 2. Bhonker Y, Abu-Rayyan A, Ushakov U, Amir-Zilberstein A, Shaked spiral ganglion cells, the auditory system collects Shivatzki S, Ofer Yizhar-Barnea O, Tal Elkan-Miller T, Einav Tayeb- sounds and transforms their mechanical forces Fligelman E, Kim SM, Landau M, Kanaan K, Chen P, Matsuzaki F, into an electrical signal that functions throughout Sprinzak D, Avraham K.B. (2015). The GPSM2/LGN GoLoco motifs our lifetime. At a molecular level, the interactions are essential for hearing. Mamm. Genome, 27:29-46. of DNA, RNA and proteins of the auditory system orchestrate a remarkable feat that is summarized in our ability to hear. The challenge in auditory science is to determine which and how a pathogenic variant in a gene or regulatory element can cause the entire hearing system to fail. Our group is asking the questions: (1) What are the genes that lead to hearing loss, and how are they involved in normal function of the inner ear? (2) How does regulation of gene expression govern the pathways that determine inner ear function, and how do alterations in regulation, on a genetic and epigenetic level, contribute to the pathology of deafness?
17 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Uri Ashery
Affiliation: Life Sciences Email: [email protected] Web: http://www.tau.ac.il/lifesci/departments/neuro/members/ashery/ashery.html
Research Title Research Description Molecular mechanisms of synaptic transmission Our laboratory investigates the functions of key synaptic proteins in synaptic transmission and Selected Publications: plasticity, both in health and in neurodegenerative 1. Bar-On D, Wolter S, van de Linde S, Heilemann M, Nudelman G, diseases. The lab applies a multidisciplinary Nachliel E, Gutman M, Sauer M, Ashery U. (2012). Super-resolution approach, pooling expertise in molecular biology, Imaging Reveals the Internal Architecture of Nano-sized Syntaxin electrophysiology, biochemistry, optogenetics, high- Clusters. J Biol Chem. 2012 3;287(32):27158-67 end imaging and computer-simulation techniques, 2. Bielopolski, N., Lam, A. D., Bar-On, D., Sauer, M., Stuenkel, E. L., and to understand how neurons communicate at the Ashery, U. (2014). Differential interaction of tomosyn with syntaxin cellular and molecular levels to influence animal and SNAP25 depends on domains in the WD40 beta-propeller core behavior. Recently, we integrated a novel method, and determines its inhibitory activity. J Biol Chem 289, 17087-17099. termed super-resolution microscopy, enabling 3. Ehmann, N., van de Linde, S., Alon, A., Ljaschenko, D., Keung, X. Z., the detection of protein distribution at single- Holm, T., Rings, A., DiAntonio, A., Hallermann, S., Ashery, U., Heckmann, molecule 20-nm resolution. Using several super- M., Sauer, M., and Kittel, R. J. (2014). Quantitative super-resolution resolution methods (dSTORM, STED) and combining imaging of Bruchpilot distinguishes active zone states. Nat Commun experimental and computational capabilities, our 5, 4650. group described how the spatial distribution of synaptic proteins from the SNARE and active zone families influences synaptic transmission (J. Biol. Chem. 2012; J. Biol. Chem. 2014; Nat. Commun. 2014). We are now using this system to investigate how the alpha synuclein protein forms aggregates, and to discover the mode of action of specific inhibitors, such as chemical chaperones and aromatic small molecules. Work is performed on brain slices, induced pluripotent stem cells and cell lines.
18 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Itai Benhar
Affiliation: Life Sciences Email: [email protected] Web: http://www.tau.ac.il/lifesci/departments/biotech/members/benhar/benhar.html
Research Title it. This ability laid the ground for classical phage Targeted nanomedicines therapy, in which phages that kill disease-causing bacteria are isolated from their natural habitats. Selected Publications: Our application, however, is totally different, as 1. Artzy-Schnirman A, Blat D, Talmon Y, Fishler R, Gertman D, Oren R, we do not rely on the natural ability of the virus Wolchinsky R, Waks T, Benhar I, Eshhar Z, Sivan U, Reiter Y. (2011). to kill its host. Rather, we regard it as a long and Electrically controlled molecular recognition harnessed to activate thin nanoparticle that can be tailored to fulfill a a cellular response. Nano Lett. 11(11):4997-5001. specific purpose. 2. Vaks L, Benhar I. (2011). In vivo characteristics of targeted drug- Filamentous phages are a family of bacterial viruses carrying filamentous bacteriophage nanomedicines. J. Nanobiotech that have only about 10 genes and grow in well- 9:58. characterized hosts - the Gram-negative bacteria. 3. Saggy I, Wine Y, Shefet-Carasso L, Nahary L, Georgiou G, Benhar I Structurally, the filamentous phage is a particle of (2012) Antibody isolation from immunized animals: comparison nanometric dimensions comprising a sheath of of phage display and antibody discovery via V gene repertoire. several thousand coat proteins in a helical array, 4. Levi O, Tal B, Hileli S, Shapira A, Benhar I, Grabov P, Eliaz N (2016). which, during phage maturation, self-assemble Optimization of EGFR high positive cell isolation procedure by around a single-stranded circular DNA molecule at design of experiments methodology. Cytometry B Clin Cytom. the core. A few minor proteins cap the particle at 2015 Sep-Oct;88(5):338-47. doi: 10.1002/cyto.b.21246. Epub 201. each end. Our group presented a novel technology 5. Halperin A, Shadkchan Y, Pisarevsky E, Szpilman AM, Sandovsky - related to the field of targeted drug delivery - in H, Osherov N, Benhar I (2016). Novel Water-Soluble Amphotericin which the phages function as targeted drug-carrying B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy. J phage nanoparticles. Med Chem. 2016 Feb 11;59(3):1197-206. For several years now we have been developing new techniques to genetically modify these viruses to Research Description carry drugs to specific locations in the body, in order For several years we have been developing targeted drug-carrying to treat various diseases, such as cancer and fungal nanomedicines, based on a core technology of genetically and chemically infections. This approach is based on genetically engineered virus particles. We developed such guided missiles to treat modifying and chemically manipulating the phages: devastating diseases, such as life-threatening infections caused by the genetic manipulation endows the phages with drug-resistant bacteria, and also for potential cancer therapy. Currently, the ability to display a host-specificity-conferring we are focusing our efforts on developing treatments of this type for ligand (target-specific peptide, recombinant pathogenic fungi that cause life-threatening lung infections in cystic antibody or other target-specifying entity) on fibrosis and transplant patients. In this novel work, the drug carriers their surface. Chemically, the bacteriophages are are none other than genetically and chemically engineered viruses. conjugated through labile linkages that are subject Usually considered vicious pathogens, viruses can also be helpful to to controlled cleavage to a drug. These targeted humans. In particular, viruses named bacteriophages, that attack bacteria, drug carrying phage nanoparticles have a large can be used for killing bacteria resistant to antibiotics, or other cells that drug-carrying capacity in excess of ten thousand bear disease. Bacteriophages (phages) thrive in bacteria, and in many drug molecules per target site. cases kill the host bacteria once they have finished multiplying within Previously, we evaluated the effectiveness of this
19 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
approach for the elimination of pathogenic bacteria and for cancer make the drug water soluble. In a recently published therapy. In our current project, we develop such phages to treat article we described the drug properties of these recalcitrant fungal infections. The antibodies in this case are specific compounds as free drugs: they are still very potent for binding with the pathogenic fungus – Aspergillus fumigatus (AF) as anti fungals, but very much reduced in non- - that causes life-threatening lung infections in immunocompromised specific toxicity. patients. The drug Amphotericin B is to be linked to the phages by Next we plan to complete the complicated task means of chemical conjugation, through a genetically engineered labile of conjugating the drug to the phages, and then linker, subject to controlled release as a result of proteolytic activity of test the efficiency of our drug delivery system in the fungal protease Alp1. killing the fungus in culture and in a mouse lung At present we are working on conjugating the drug to the phages. To infection model. this end we synthesized PEG conjugates of amphotericin B (AMB), to
20 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Noam Shomron
Affiliation: Medicine Email: [email protected] Web: www.tau.ac.il/~nshomron
Research Title Research Description Genomics of human diseases The Shomron research team focuses on the analysis of genomics, aimed at understanding human Selected Publications: diseases. Combining high-throughput methods and 1. Isakov O, Perrone M, Shomron N. Exome sequencing analysis: a guide bioinformatics, our team explores gene regulators, to disease variant detection. Methods Mol Biol. 2013;1038:137-58. such as microRNAs, in order to reach a global systems 2. Gilam A, Edry L, Mamluk-Morag E, Bar-Ilan D, Avivi C, Golan D, perspective on the mechanistic roles small RNA Laitman Y, Barshack I, Friedman E, Shomron N. Involvement of IGF- play during disease development. 1R regulation by miR-515-5p modifies breast cancer risk among Among our projects: Identifying microRNAs located BRCA1 carriers. Breast Cancer Res Treat. 2013 Apr;138(3):753-60. at the intersection of several oncogenes; Controlling 3. Mor E, Kano S, Colantuoni C, Sawa A, Navon R, Shomron N. metastatic breast cancer via nanoparticles releasing MicroRNA-382 expression is elevated in the olfactory neuroepithelium microRNAs; Revealing the influence of microRNAs of schizophrenia patients. Neurobiol Dis. 2013 Jul;55:1-10. on pharmacogenomics and personalized medicine; 4. Shomron N. Genetics research: jumping into the deep end of the Exposing pathogens in human tissues based on pool. Genet Res (Camb). 2013 Feb;95(1):1-3. deep sequencing of small RNA molecules. 5. Isakov O, Ronen R, Kovarsky J, Gabay A, Gan I, Modai S, Shomron Overall, our team pursues research that aims to N. Novel insight into the non-coding repertoire through deep deepen our understanding of the development of sequencing analysis. NucleicAcids Res. 2012 Jun;40(11):e86. diseases, in order to generate a significant impact through translating ideas into clinical reality.
21 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Avigdor Eldar
Affiliation: Life Science Email: [email protected] Web: http://www6.tau.ac.il/eldar/
Research Title Research Description Elucidating bacterial communication systems Our main interest is in understanding the design principles of cooperative behavior in bacteria. Selected Publications: More specifically, we focus on how bacterial 1. Avigdor Eldar (2011). Social conflict drives the evolutionary divergence communication (also known as quorum sensing) of quorum sensing. Proceedings of the National Academy of Science, is involved in the regulation of cooperation. Our 108 (33): 13635-13640 Partial penetrance facilitates developmental aim is to elucidate the impact of social structure, evolution in bacteria. spatial form and phenotypic heterogeneity on the 2. Avigdor Eldar,Vasant K. Chary, Panos Xenopoulos, Michelle E. development of cooperation and its evolution. In Fontes,Oliver C. Losón, Jonathan Dworkin, Patrick J. Piggot PJ, Michael order to study the phenomenon of cooperation B. Elowitz. (2009). Self-Enhanced Ligand Degradation Underlies in simple and complex structures we combine Robustness of Morphogen Gradients Nature, 460(7254):510-4 tools from microbiology, genetics, molecular 3. Avigdor Eldar, Dalia Rosin, Ben-Zion Shilo and Naama Barkai. (2003). biology, microscopy and quantitative modeling. Robustness of the BMP morphogen gradient in Drosophila embryonic Our main model organisms are the gram-positive patterning Developmental Cell, Vol 5, 635-646 soil bacteria B. subtilis and the gram-negative 4. Avigdor Eldar, Ruslan Dorfman, Daniel Weiss, Hilary Ashe, Ben-Zion pathogen P. aeruginosa. These two organisms Shilo and Naama Barkai. (2002). Functional Roles for Noise in Genetic are major model systems of quorum sensing and Circuits. Nature 419, 304-308 (2002). biofilm development, allowing us to use their superb 5. Avigdor Eldar and Michael Elowitz. (2010). Nature, 467(7312):167-173. genetic tools and vast knowledge base as a starting point for our investigation.
22 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Roy Beck
Affiliation: Physics Email: [email protected] Web: http://www6.tau.ac.il/beck/
Research Title In order to properly study biological systems and Nanoscale biophysics the interactions within them, it is important to have complementary techniques covering different Selected Publications: length and energy scales, with proximity to their 1. G. Jacoby, K. Cohen, K. Barkan, Y. Talmon, D. Peer, R. Beck, Predetermined natural environment. In our laboratory we purify the and controlled metastable phase transition in lipid-based particles. subunit biological building blocks, using a variety Scientific Reports 5, 9481 (2015). DOI: 10.1038/srep09481 of state-of-the-art biochemical and molecular 2. S. Pregent, A. Lichtenstein, R. Avinery, A. Laser-Azogui, F. Patolsky, R. techniques. We then reassemble them in precise Beck, Probing the interactions of intrinsically disordered proteins conditions, to extract the underlying physics using nanoparticle tags. Nano Letters (2015). DOI: 10.1021/acs. pertaining to their supramolecular forces, dynamics nanolett.5b00073. and steady-state structures - particularly as they 3. M. Kornreich, E. Malka-Gibor, A. Laser-Azogui, O. Doron, H. Herrmann, appear in healthy and diseased states. R. Beck, Composite bottlebrush mechanics: α-Internexin fine-tunes We use small and wide angle x-ray scattering (WAXS neurofilament network properties. Soft Matter 11, 5839-5849 (2015). & SAXS) to cover length scales from 0.1-100 nm. DOI: 10.1039/C5SM00662G These techniques are suitable for measuring weak 4. L. Almagor, R. Avinery, J. Hirsh, R. Beck, Structural flexibility of CaV scattering from biological systems in their natural 1.2 and CaV 2.2 proximal linker fragments in solution, Biophysical environment. Detailed analysis and advanced Journal 104, 2392-2400 (2013), DOI: 10.1016/j.bpj.2013.04.034, computational techniques are regularly used PMID: 23746511 to convert the reciprocal space into real-space 5. R. Beck, J. Deek, J.B. Jones, C.R. Safinya, Gel Expanded to Gel structures, and enable studies on the nature of Condensed Transition in Neurofilament Networks revealed by Direct the interactions within the biological assemblies. Force Measurements, Nature Materials 9, 40-46 (2010),PMID:19915555 SAXS, in particular, provides a ready means for determining inter-filament spacing and interactions. Research Description Recent advances in solid-state type x-ray detectors In many significant biological functions the four basic building and high-flux microfocus x-ray sources allow blocks (proteins, lipids, sugars and nucleic acids) aggregate to form investigation of dynamic structural events, as well supramolecular structures and assemblies. The forces and interactions as highly penetrated measurements. Conveniently, responsible for these assemblies are composed of a set of interactions these approaches do not require staining or other with energy scales ranging from thermal fluctuations (a few KT) to modifications, and thus do not perturb our system, specific covalent bonds (100s of KT). Relevant length scales in biological allowing easier access to the supramolecular forces systems also span many orders of magnitude, from the single amino underlying self-assembly, and simplifying data acid through polypeptide chains, protein complexes and organelles, all analysis. the way up to cells and organs. These different scales present enormous challenges, both experimentally and theoretically.
23 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Yael Roichman
Affiliation: Chemistry Email: [email protected] Web: http://www.tau.ac.il/~roichman/
Research Title Research Description Experimental studies of soft matter with holographic optical In our group we are interested in understanding tweezers the principles governing the behavior of systems out of thermal equilibrium. To this end we use Selected Publications: a combination of optical imaging and optical 1. Diffusion of a nano-wire through an obstacle field, Dror Kasimov, manipulation to probe and image soft materials and Tamir Admon, and Yael Roichman, PRE in press (2016) complex fluids. We believe that by studying in detail 2. Tomographic phase microscopy with 180o rotation of live cells in many model systems far from thermal equilibrium, suspension by holographic optical tweezers, Mor Habaza, Barak we will be able to see emergent universalities. In Gilboa, Yael Roichman, and Natan T. Shaked, Optics Lett., 40, 1881- the past few years we have studied two different 1884 (2015). systems driven out of equilibrium in different ways: 3. Viscoelastic respone of a complex fluid at intermediate distances, optically driven colloidal suspensions, and in-vitro Adar Sonn-Segev, Anne bernheim-Groswasser, Haim Diamant, and cytoskeleton networks containing molecular motors. Yael Roichman, Phys. Rev. Lett., 112, 088301 (2014). Technically, the experimental work in the group 4. Independent and simultaneous three-dimensional optical trapping is based on video microscopy, particle tracking and imaging. Maya Yevnin, Dror Kasimov, Yael Gluckman, Yuval and image velocimetry for studying the dynamics Ebenstein, and Yael Roichman, Biomedical Optics Express, 4, 2087- and kinetics of particles in our model systems, and 2094 (2013). microrheology for characterizing their mechanical 5. Hydrodynamic Pair Attractions between Driven Colloidal Particles, properties. In addition, we develop optical imaging Yulia Sokolov, Derek Frydel, David G. Grier, Haim Diamant, and Yael techniques with improved resolution and speed, Roichman, Phys. Rev. Lett., 107, 158302, (2011). and combine various 3D imaging techniques with optical trapping and manipulation.
24 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Yair Shokef
Affiliation: Mechanical Engineering Email: [email protected] Web: http://shokef.tau.ac.il/
arrange themselves and behave similarly to atoms Research Title and molecules comprising materials found in nature. Non-equilibrium statistical mechanics of soft matter However, colloids and grains are large enough, and move slowly enough, to allow experiments that directly Selected Publications: show us their dynamics at the single-particle level. The 1. A. Ghosh, E. Teomy, and Y. Shokef, Jamming percolation in three analogy with these systems thus enables us to visualize dimensions, Europhysics Letters 106, 16003 (2014). microscopic processes governing the macroscopic 2. E. Teomy and Y. Shokef Finite-density effects in the Fredrickson-Andersen characteristics and dynamic properties of complex and Kob-Andersen kinetically-constrained models, The Journal of materials, which are otherwise very poorly understood. Chemical Physics 141, 064110 (2014). Our current research efforts focus on two main topics: 3. Y. Shokef and S.A. Safran, Scaling laws for the response of nonlinear jammed matter and active matter. elastic media with implications for cell mechanics, Physical Review The first involves using lattice-based models to Letters 108, 178103 (2012). study disordered soft materials such as powders, 4. Y. Shokef, A. Souslov, and T.C. Lubensky, Order-by-disorder in the foams, colloids and glasses - the dynamics of which antiferromagnetic Ising model on an elastic triangular lattice, Proceedings are all extremely slow and cooperative. Some of of the National Academy of Sciences of the USA 108, 11804 (2011). these models jam and remain disordered, due to 5. Y. Han, Y. Shokef, A.M. Alsayed, P. Yunker, T.C. Lubensky, and A.G. Yodh, geometric frustration - namely the inability of a system Geometric frustration in buckled colloidal monolayers, Nature 456, to simultaneously satisfy all of its local constraints, 898 (2008). making it difficult for it to reach a global optimum which minimizes the relevant free energy. Other Research Description models, studied analytically and numerically, consist Our group conducts theoretical research into the dynamical behavior of soft of kinetically constrained dynamics. Here the geometry materials, using models and concepts inspired by recent developments in is implemented effectively by directly defining which the statistical mechanics of systems far from thermodynamic equilibrium. dynamical moves are allowed and which are forbidden, Many soft systems encountered in everyday life, such as glasses, colloidal in ways that may generate jamming similar to that suspensions (ink), granular media (sand), emulsions (milk) and foams found in more complicated models. (shaving cream), as well as most biological systems, are very far from The second line of research includes the study of thermal equilibrium. Even though they are in close contact with a thermal fluctuations generated in biological systems due environment, they are either (i) strongly driven by mechanical or biological to the presence of molecular motors within them. forces with a perpetual current of energy, from the driving source through These motors consume chemical energy and generate the system and out into the dissipative environment, or (ii) they fall into mechanical forces which drive the system out of metastable glassy states and fail to equilibrate with their surroundings. The thermodynamic equilibrium. Moreover, biological typical energy scales of fluctuation in a sheared colloid, in the membrane of a materials have a very nonlinear mechanical response, red blood cell, or in a solution with bacteria swimming in it, are considerably and therefore the macroscopic mechanical properties higher than the thermal energy. More dramatically, for a pile of sand or of biological systems are very different from those flour, thermal energy is negligible compared to the energy required for of passive materials. Our activity along this avenue a single grain to overcome gravity and hop over one of its neighbors. includes the use of stochastic models for the dynamics On top of the compelling biological and industrial interests in such in conjunction with geometrical descriptions of the materials, soft matter systems are useful as mesoscopic models of molecular nonlinear, finite-deformation elasticity of biological systems. Nano-, micro- or millimeter- scale droplets, colloids and grains materials.
25 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Tamir Tuller
Affiliation: Bio-medical Engineering Email: [email protected] Web: http://www.cs.tau.ac.il/~tamirtul/
Research Title Research Description Deciphering, modeling and engineering gene expression Gene expression is the process by which information encoded in the genome is used to synthesize Selected Publications: intra-cellular molecules such as proteins, which 1. Dana, A., Tuller, T. (2014) The effect of tRNA levels on decoding are involved in all intra-cellular activities. The times of mRNA codons. Nucleic Acids Res. Jul 23. genetic code is a table that translates triplets of 2. Zur,H., Tuller, T.(2014). Exploiting Hidden Information Interleaved nucleotides (alphabet of the mRNA/DNA) to amino in the Redundancy of the Genetic Code without Prior Knowledge. acids (alphabet of proteins). Bioinformatics. Nov 29. pii: btu797. There is, however, redundancy in the genetic code: 3. Diament,A., Pinter,R.Y., Tuller, T.(2014). Three-dimensional eukaryotic 61 triplets of nucleotides actually code only 20 amino genomic organization is strongly correlated with codon usage acids. In this redundancy and also in the non-coding expression and function. Nature Communications. 16 Dec 2014. regions, some aspects of gene expression - e.g. the 4. Ben-Yehezkel, T., Atar,S., Zur,H., Diament,A., Goz,E., Marx,T., Cohen,R., rate at which the proteins will be generated - can Dana,A., Feldman,A., Shapiro,E., Tuller, T. (2015) Rationally designed, be (at least partially) encoded. heterologous S. cerevisiae transcripts expose novel expression Our group is working on: 1) Deciphering how gene determinants. RNA Biol. 12(9):972-84. expression is usually encoded in the transcript itself, 5. Raveh, A., Margaliot, M., Sontag, E.D. Tuller,T. (2016). A model for affecting its evolution; 2) Developing and analyzing competition for ribosomes in the cell. J. R. Soc. Interface. Mar;13(116). computational/ mathematical/statistical/biophysical models that represent these rules; 3) Developing novel approaches to computer-aided design (CAD), and engineering gene expression based on these models.
26 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Sharly Fleischer
Affiliation: Chemistry Email: [email protected] Web: https://sites.google.com/site/terahertzandultrafastlab/
Research Title Research Description Ultrafast terahertz and optical coherent control of molecules Just as light is affected by the matter it interacts with in traditional spectroscopy, the state of matter can Selected Publications: also be altered by light, and coherently driven to 1. Kallush, S., and Fleischer, S. (2015). Orientation dynamics of asymmetric yield a desired goal. This field of research is known rotors using random phase wave functions, Phys. Rev. A 91, 063420. as ‘coherent control’. 2. Fleischer, S., Field, R.W, and Nelson, K. (2014), From populations to Interested in both these mutually complementary coherences and back again – a new insight about rotating dipoles, processes, we use intense femtosecond light fields arXiv:1405.7025.of the Genetic Code without Prior Knowledge. in both the terahertz range (THz fields, 10^12 Hz) Bioinformatics. Nov 29. pii: btu797. and the visible/near-IR range (optical fields, 10^15 3. Fleischer, S., Field, R.W, and Nelson, K. (2012). Commensurate two Hz) to coherently control and spectroscopically quantum coherences induced by time delayed THz fields, Phys. study the dynamics of molecules. Rev. Lett. 109, 123603. We develop new control schemes based on 4. Fleischer, S., Zhou, Y., Field, R.W, and Nelson, K. (2011). Molecular combined excitation by THz and optical fields, orientation and alignment by intense single-cycle THz pulses, Phys. acting as two distinct molecular handles. We utilize Rev. Lett. 107, 163603. these fields to induce unique angular distributions 5. Fleischer, S., Averbukh, I.Sh., and Prior, Y., (2007). Selective Alignment in molecular ensembles, and then study them of Molecular Spin Isomers, Phys. Rev. Lett. 99, 093002. via advanced ultrafast spectroscopic methods. With the help of intense light fields, we wish to control and study molecules of increasing size and complexity, and ultimately apply these methods to big molecules and nanostructures of chemical and biological interest.
27 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Eli Eisenberg
Affiliation: Physics Email: [email protected] Web: http://www.tau.ac.il/~elieis
Research Title Research Description Computational analysis of RNA expression data, focusing on We use the bioinformatic approach and statistical RNA editing modeling to analyze RNA expression data. In particular, we have developed methods for Selected Publications: identification, quantification and analysis of A-to-I 1. Paz-Yaacov, L. Bazak, H.T.Porath, I. Buchumenski, M. Danan-Gotthold, RNA editing, an endogenous process in which the B.A. Knisbacher, E. Eisenberg and E.Y. Levanon. Elevated RNA Editing RNA is enzymatically modified from its genomic Activity is a Major Contributor to Transcriptomic Diversity in Tumors, blueprint. Cell Reports 13, 267-276 (2015) 2. S. Alon, S.C. Garrett, E.Y. Levanon, S. Olson, B.R. Graveley, J.J.C. Rosenthal and E. Eisenberg. The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing, eLife 4, e05198 (2015). 3. L. Bazak, A. Haviv, M. Barak, J. Jacob-Hirsch, P. Deng, R. Zhang, F.J. Isaacs, G. Rechavi, J.B. Li, E. Eisenberg and E.Y. Levanon. A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes, Genome Research 24, 365-376 (2014). 4. E. Eisenberg and E.Y. Levanon. Human housekeeping genes, revisited, Trends in Genetics, 29, 569-574 (2013). 5. S. Alon, E. Mor, F. Vigneault, G. Church, F. Locatelli, F. Galeano, A. Gallo, N. Shomron and E. Eisenberg, Systematic identification of edited microRNAs in the human brain Genome Research, 22, 1533- 1540 (2012).
28 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Amir Goldbourt
Affiliation: Chemistry Email: [email protected] Web: kuwari.tau.ac.il
Research Title Research Description Biomolecular solid state NMR Research in our group focuses on developing and applying magic-angle spinning solid state NMR Selected Publications: for the study of complex systems, with a particular 1. O. Morag, G. Abramov, A. Goldbourt (2014). Complete chemical emphasis on structural virology. shift assignment of the ssDNA in the filamentous bacteriophage One example is the family of filamentous fd reports on its conformation and on its interface with the capsid bacteriophages: bacteria-infecting viruses that shell, J. Am. Chem. Soc. 136, 2292-2301. share a similar virion structure and life cycle. The 2. E. Nimerovsky, R. Gupta, J. Yehl, M. Li, T. Polenova, A. Goldbourt virion is composed of a circular ssDNA wrapped by (2014). Phase-modulated LA-REDOR: A robust, accurate and efficient thousands of similar copies of a major coat protein, solid-state NMR technique for distance measurements between with several different minor coat proteins at both a spin-1/2 and a quadrupole spin., J. Magn. Reson. 244, 107-113. ends. Our group prepares, purifies and uses magic- 3. O. Morag, N. G. Sgourakis, D. Baker, A. Goldbourt (2015). The NMR- angle spinning NMR techniques to characterize Rosetta capsid model of M13 bacteriophage reveals a quadrupoled the structure of various phages in atomic-detailed hydrophonic packing epitope, Proc. Natl. Acad. Sci. 112(4), 971-976. resolution. 4. L. Avram, A. Goldbourt, Y. Cohen (2016). Hexameric capsules studied Another area of interest is the NMR of metal ions, by magic angle spinning solid state NMR Spectroscopy: Identifying which play a crucial role in the function of enzymes. solvent molecules in pyrogallol[4]arene capsules. Angew. Chem. Low occupancies, dynamics and other obstacles Int. Ed. 55(3), 904-907. often hinder the detailed characterization of such 5. H. Ivanir, E. Nimerovsky, PK Madhu, A. Goldbourt (2015). Site-resolved sites, and our group addresses this challenge. We backbone and side-chain intermediate dynamics in a carbohydrate- develop and apply techniques for characterizing the binding module protein studied by magic-angle spinning NMR. structural environment of metal ions such as 11B, 51V, Chem. Eur. J., 21, 10778–10785. 7Li, 23Na and other similar nuclei exhibiting a large anisotropic interaction in the magnetic field. For example: lithium salts have been known as mood stabilizing drugs for bipolar disorder patients for over 50 years. It was hypothesized that lithium exerts its therapeutic effect by binding with the enzyme myo-inositol monophosphatase (IMPase), thereby reducing inositol levels in the blood and diminishing the hyperactive phosphatidyl-inositol cell signaling pathway. Other targets of lithium have also been proposed. Since lithium is mostly spectroscopically silent, we use magic-angle spinning NMR techniques to directly observe and characterize lithium’s binding sites in its drug targets.
29 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. David Andelman
Affiliation: Physics Email: [email protected] Web: www.tau.ac.il/~andelman
Research Title Research Description Theory of soft and biological matter We specialize in studying soft matter and biological systems, in collaboration with several experimental Selected Publications: teams worldwide. In particular, we explore the 1. Lamellar Diblock Copolymers on Rough Substrates: Self-consistent properties of self-assembling polymers, and ways Field Theory Studies, X. K. Man, J. Tang, P. Zhou, D. Yan, and D. to manipulate them at patterned surfaces and in thin Andelman, Macromolecules 48, 7689-7697 (2015). http://arxiv. film geometries, in relation with nanolithography. org/abs/1506.06854. Another line of research is the exploration of bio- 2. Contact Angle Saturation in Electrowetting: Injection of Ions into the and soft matter systems in which charges play an surrounding Media, T. Yamamoto, M. Doi, and D. Andelman, Europhys. important role. We investigate ionic liquids at charged Lett. 112, 56001.1-6 (2015). http://arxiv.org/abs/1510.00613. interfaces and membranes, and the response of 3. Correlated Lateral Phase Separations in Stacks of Lipid Membranes, T. ionic solutions and charged macromolecules to Hoshino, S. Komura, and D. Andelman, J. Chem. Phys. 143, 243124.1- external electric fields. 9 (2015). http://arxiv.org/abs/1508.03942. 4. Surface Tension of Electrolyte Interfaces: Ionic Specificity within a Field Theory Approach, T. Markovich, D. Andelman, and R. Podgornik, J. Chem. Phys. 142, 044702.1-13 (2015). http://arxiv.org/abs/1411.5222. 5. Charge-induced Phase Separation in Lipid Membranes, H. Himeno, N. Shimokawa, S. Komura, D. Andelman, T. Hamada, and M. Takagia, Soft Matter 10, 7959-7967 (2014). http://arxiv.org/abs/1405.4650.
30 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Natan Shaked
Affiliation: Bio-medical Engineering Email: [email protected] Web: www.eng.tau.ac.il/~omni
Research Title Research Description Biomedical optical microscopy, nanoscopy and interferometry We are interested in the development of interferometric imaging methods for nano-profiling Selected Publications: of thin elements, such as live biological cells in vitro, 1. P. Girshovitz and N. T. Shaked, Doubling the field of view in off-axis lithography processes and semiconductor wafers. low-coherence interferometric imaging, Nature – Light: Science Specifically, we develop interferometric and and Applications (Nature LSA), Vol. 3, e151, pp. 1-9, 2014. tomographic phase microscopy methods that 2. P. Girshovitz and N. T. Shaked, Compact and portable low-coherence can operate outside of the optical lab, in instable interferometer with off-axis geometry for quantitative phase environments. By using compact, low-coherence, microscopy and nanoscopy, Optics Express, Vol. 21, Issue 5, pp. common-path, off-axis interferometric modules, we 5701-5714, 2013. obtain 3D imaging of live biological cells without 3. M. Habaza, B. Gilboa, Y. Roichman, and N. T. Shaked, Tomographic external labeling, and record the optical path phase microscopy with 180° rotation of live cells in suspension by delay of light passing through the sample with holographic optical tweezers, Optics Letters, Vol. 40, Issue 8, pp. sub-nanometer accuracy. Furthermore, since these 1881-1884, 2015. interferometric methods are very sensitive to local 4. O. Blum and N. T. Shaked, “Prediction of photothermal phase refractive-index changes, we develop plasmonic signatures from arbitrary plasmonic nanoparticles and experimental nanoparticles, which induce local heat changes verification, Nature – Light: Science and Applications (Nature LSA), due to photothermal excitation, as new contrast Vol. 4, e322, pp. 1-8, 2015. agents in live cells. 5. N. Turko, I. Barnea, O. Blum, R. Korenstein, and N. T. Shaked, Detection and controlled depletion of cancer cells using photothermal phase microscopy, Journal of Biophotonics, Vol. 8, Issue 9, pp. 755-763, 2015.
31 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Yael Hanein
Affiliation: Electrical Engineering Email: [email protected] Web: nano.tau.ac.il/hanein
Research Title Research Description Neuro Engineering The primary focus of our research is electronic devices for the recording and controlled stimulation of Selected Publications: brain signals. These devices are designed to address 1. Lilach Bareket, Nir Waiskopf, David Rand, Gur Lubin, Moshe David-Pur, neurological disorders which cannot be treated with Jacob Ben-Dov, Soumyendu Roy, Cyril Eleftheriou, Evelyne Sernagor, contemporary drugs. Specifically, a nanomaterial- Ori Cheshnovsky, Uri Banin, Yael Hanein, (2014) Semiconductor based artificial retina implant with outstanding Nanorod-Carbon Nanotube Biomimetic Films for Wire-Free Photo- performance was recently produced, offering a Stimulation of Blind Retinas, Nano Letters, 14 (11), pp 66856692 promising solution for blindness caused by retinal DOI: 10.1021/nl5034304. degeneration - a condition which afflicts millions 2. Vini Gautam, David Rand, Yael Hanein and K.S. Narayan, (2013) A of people worldwide. We are also developing skin polymer optoelectronic interface provides visual cues to a blind electrode arrays for reliably recording physiological retina, Advanced Materials, 10.1002/adma.201304368. signals from humans. 3. Yuval Yifat, Michal Eitan, Zeev Iluz, Yael Hanein, Amir Boag, Jacob Scheuer, (2014) Highly efficcient and broadband wide-angle Holography Using Patch-Dipole Nano-antenna Reflect arrays, Nano Letters, 14 (5), 24852490, 2014. 4. David-Pur M1, Bareket-Keren L, Beit-Yaakov G, Raz-Prag D, Hanein Y. (2014) All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation. Biomed Microdevices.16(1):43-53. doi: 10.1007/s10544-013-9804-6. 5. Gilad Wallach, Jules Lallouette, Nitzan Herzog, Maurizio De Pitta, Eshel Ben Jacob, Hugues Berry, and Yael Hanein, Glutamate Mediated Astrocytic Filtering of Neuronal Activity (2014), PLOS Computational Biology, DOI: 10.1371/journal.pcbi.1003964.
32 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Slava Krylov
Affiliation: Mechanical Engineering Email: [email protected] Web: www.eng.tau.ac.il/~vadis
Research Title Over the last several years, parametrically excited Design and modeling of micro and nano systems microstructures were an important part of research in our lab. In electrostatic devices the actuation Selected Publications: forces are typically time- and configuration- 1. J. Shklovsky, L. Engel, Y. Sverdlov, Y. Shacham-Diamand, S. Krylov,Nano- dependent functions that modulate the effective Imprinting Lithography of P(VDF-TrFE-CFE) for Flexible Freestanding stiffness, and can result in parametric excitation. MEMS Devices, Microelectronic Engineering, 100, 41-46, 2012. Our group has developed and investigated several 2. Y. Gerson, D. Schreiber, H. Grau, and S. Krylov, Meso Scale MEMS unusual approaches to the parametric excitation Inertial Switch Fabricated using Electroplated Metal on Insulator of microstructures. (MOI) Process, J. Micromech. Microeng., 24, pap. 025008, 2014. The insights gained from the investigation of 3. S. Krylov, S. Lulinsky, B. R. Ilic, I. Schneider, Collective Dynamics microstructures, along with the exploration of and Pattern Switching in an Array of Parametrically Excited Micro new actuation and sensing principles, serve as Cantilevers Interacting Through Fringing Electrostatic Fields, Applied a basis for implementing these approaches in Physics Letters, 105, 071909, 2014. applications. The development of new concepts 4. L. Medina, R. Gilat, B.R. Ilic, S. Krylov, Experimental Investigation of The of sensors in general, and of inertial sensors (angular Snap-Through Buckling of Electrostatically Actuated Initially Curved rate sensors and accelerometers) in particular, is Pre-Stressed Microbeams, Sensors and Actuators A, 220, 323–332, 2014. essentially based on the results of more fundamental 5. Y. Borisenkov, M. Kholmyansky, S. Krylov, A. Liberzon and A. theoretical and experimental research. Recently we Tsinober, Multi-Array Micromachined Probe for Turbulence developed a micro accelerometer incorporating Measurements Assembled of Suspended Hot-Film Sensors, IEEE bistable elements and based on stability boundaries J. of Microelectromechanical Systems, 24(5), pp. 1503-1509, 2015. monitoring. The device was fabricated at TAU and its functionality was demonstrated. Research Description One of the most promising directions today is the Our research combines theoretical, experimental and applied aspects in use of polymeric materials in MEMS/NEMS. While the area of modeling, design, fabrication and characterization of micro- well-established technologies based on silicon as and nanoelectromechanical systems (MEMS/NEMS). Our efforts focus a main structural material are widely used, and on the development of new approaches to actuation and sensing and have been successfully commercialized, they are their implementation in applications, as well as the study of the typically less suitable for implementation in medical micro nonlinear electromechanical phenomena in microscale structures. A devices. In addition, polymeric MEMS devices can better understanding of physical phenomena, gained through extensive be naturally integrated with flexible electronics to investigation, lays the foundation for the possible development of form a unified sensing platform. In this context, our new designs and operational concepts for micro and nano devices. group (in collaboration with Prof. Yosi Shacham), The dynamics and stability of micro- and nanostructures is one is currently developing a generic technology central direction of our current activity. One of the distinguishing based on the design, fabrication and integration features of electrostatically, magnetically or electro-thermally actuated of miniature devices fabricated from electroactive microstructures is that they are inherently nonlinear, and can become or/and conductive polymers and electroactive gels. unstable. Our research sheds light on the dynamic behavior and stability Recently these endeavors were extended to the of microstructures, and inspires a generation of new concepts for using implementation of 3D printing techniques for these phenomena in applications. fabrication of micro devices.
33 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Gil Rosenman
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~gilr
Research Title Research Description Physical properties of bioinspired nanomaterials Ultrashort aromatic and aliphatic di- and tripeptide biomolecular nanostructures of different origin and Selected Publications: native conformation at the nanoscale are studied 1. S. Semin, A. van Etteger, N. Amdursky, L. Kulyuk, S. Lavrov, A. Sigov, by monitoring their basic physical properties E. Mishina, G. Rosenman, and Th. Rasing, (2015). Strong Thermo- during a thermally induced phase transition. We Induced Single And Two-Photon Green Luminescence In Self- show that this fundamental process, found by us Organized Peptide Microtubes, Small, 11, 1156–1160. in bioorganic systems, is governed by the thermally 2. A. Handelman, G. Shalev, G. Rosenman, Symmetry of Bioinspired activated reconformation of biomolecules, or their Peptide (2015). Nanostructures and Their Basic Physical Properties, spatial reconfiguration. Regardless of the origin of Israel Journal of Chemistry, 55, 637–644. di- and tripeptides and their native architecture, the 3. A. Handelman, N.Kuritz, A. Natan and Gil Rosenman, (2016). phase transition takes place by full refolding into Reconstructive Phase Transition in Ultrashort Peptide Nanostructures another similar, irreversible, and thermodynamically and Induced Visible Fluorescence, Invited Feature Article, Langmuir, stable fiber-like nanowire morphology. In 32 (12), 2847–2862. this new supramolecular arrangement, newly 4. A. Handelman, B. Apter, N.Turko and Gil Rosenman. (2016). observed bioorganic nanodots, with β-sheet Linear and Nonlinear Optical Waveguiding Effects in Bio-inspired structure and deep reconstruction found at all Diphenylalanine Peptide Nanotubes, Acta Biomater, 30, 72–77. levels (molecular, electronic, peptide secondary 5. A.Handelman, S. Lavrov, A. Kudryavtsev, S. Semin, E. Mishina and structure, morphological, etc.) generate new G.Rosenman, Nonlinear Optical Phenomena in Bioinspired Peptide physical properties and the appearance of blue/ Nanostructures and Optical Waveguide properties ,Review paper, green photoluminescence. Encyclopedia of Nanoscience and Nanotechnology, 10-volume set.
34 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Yuval Ebenstein
Affiliation: Chemistry Email: [email protected] Web: http:// www.nanobiophotonix.com
Research Title Research Description Single-molecule genomics Our lab specializes in many areas of optical imaging and spectroscopy, with emphasis on single-molecule Selected Publications: detection and the development of imaging- 1. Ebenstein, Y, Y. Michaeli, T. Shahal, D. Torchinsky, A. Grunwald, R. Hoch, based techniques. Our research focuses on the and Optical detection of epigenetic marks: Sensitive quantification application of novel imaging and optical detection and direct imaging of individual hydroxymethylcytosine bases. approaches to genomic studies and biomarker Chem. Commun., (2013) 49 (77), 8599 - 8601 detection. We develop new spectroscopy and 2. Ebenstein Y., M. Levy-Sakin, Beyond Sequencing: Optical mapping microscopy methodologies that combine advanced of DNA in the Age of Nanotechnology and Nanoscopy. Current optics with tools and reagents from the realm of Opinion in Biotechnology (2013) 24, (4), 690-698. nanotechnology. In addition, we have great interest 3. Ebenstein, Y., Weiss, S., Levy-Sakin M., Grunwald A., Kim, S., Gottfried, in developing unique biochemistries for genomic A., Lin, R.R., Dertinger, T., Kim, A.S., Chung, S., Colyer, R.A., Weinhold, analysis, based on chemo-enzymatic reactions. E., Towards Single-Molecule Optical Mapping of the Epigenome. ACS Nano, (2014) 8, (1), 14-26. 4. Yuval Ebenstein, Jeremy Don, Shahar Zirkin, Sivan Fishman, Hila Sharim, Yael Michaeli, Lighting Up Individual DNA Damage Sites by In Vitro Repair Synthesis. JACS (2014), 136, (21), 7771–7776. 5. Ting F. Zhu, Yuval Ebenstein, Chunbo Lou, Wenjun Jiang, Xuejin Zhao, Tslil Gabrieli, Cas9-Assisted Targeting of CHromosome segments (CATCH) enables one-step targeted cloning of large gene clusters. Nat.Comm., (2015).
35 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY
RESEARCHERS
Prof. Yosi Shacham
Affiliation: Electrical Engineering Email: [email protected] Web: eng.tau.ac.il/~yosish
Research Title cobalt alloys were found to be very useful as barrier Interconnect micro and nano fabrication and capping layers for Cu metallization. The most useful barrier and capping layers were made of Selected Publications: alloys of cobalt and nickel with refractory metals 1. Yoetz-Kopelman, T., Dror, Y., Shacham-Diamand, Y., & Freeman, (tungsten, molybdenum or rhenium) and also with A. “Cells-on-beads”: A novel immobilization approach for the phosphorus or boron. construction of whole-Cell amperometric biosensors. Sensors The coupling of living cells, serving as sensor and Actuators B: Chemical, (2016). elements, with microelectronic devices, provides 2. Ram, Y., Yoetz-Kopelman, T., Dror, Y., Freeman, A., & Shacham-Diamand, novel opportunities for biosensors performing as Y. (2016). Impact of Molecular Surface Charge on Biosensing by stable, sensitive, specific and accurate electronic Electrochemical Impedance Spectroscopy. Electrochimica Acta. devices. Electroless Deposition methods, in 3. Hemed, N. M., Convertino, A., & Shacham-Diamand, Y. (2016). which metal cations are chemically reduced by a Investigation of Functionalized Silicon Nanowires by Self-Assembled reducing agent into a deposited metallic film, may Monolayer. Applied Surface Science. (Accepted for publication). provide a new and effective tool for the coupling 4. Yoetz-Kopelman, T., Porat-Ophir, C., Shacham-Diamand, Y., & Freeman, of biological activities and electronic circuits. A. (2016). Whole-cell amperometric biosensor for screening of Electrical characteristics (conductivity) and structure cytochrome P450 inhibitors. Sensors and Actuators B: Chemical, preservation are achieved by coating the structure 223, 392-399. with a thin metal film. 5. Feiner, R., Engel, L., Fleischer, S., Malki, M., Gal, I., Shapira, A., Shacham- The main goal of our research is to study the new Diamand Y. & Dvir, T., Engineered hybrid cardiac patches with concept of integration of metallized whole cells multifunctional electronics for online monitoring and regulation with electronically interfacing biosensors. In order of tissue function. Nature materials. 2016. to miniaturize the biosensors we want to work with a single cell or a small number of cells located Research Description within a small area on a chip. To achieve this, we Cu interconnect requires barrier layers to prevent Cu diffusion into the must be able to control the location of the cell on dielectrics and the Si substrate. Cu lines also require capping layers the electrode, and to provide electrical contact to prevent oxidation and improve reliability, by reducing Cu surface between cell and electrode. We hypothesize that electromigration - mostly at the top interface where the Cu was exposed by using cells metallized by electroless deposition to chemical mechanical polishing during the “Dual Damascene” fully we can achieve both goals. embedded metal positive patterning process. Electroless nickel and
36 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Shachar Richter
Affiliation: Materials Science and Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~srichter/
Research Title Research Description Bio and molecular electronics In our group we adopt a bottom-up approach to develop and explore various properties of Selected Publications: nanomaterials, self-assembled monolayers and 1. Sidelman, Noam, Moshik Cohen, Anke Kolbe, Zeev Zalevsky, Andreas thin films. We start from the molecular level, and Herrman, and Shachar Richter. Rapid Particle Patterning in Surface use molecular synthesis to form the desired basic Deposited Micro-Droplets of Low Ionic Content via Low-Voltage structures which, in the next stage, are incorporated Electrochemistry and Electrokinetics. Scientific Reports 5 (2015). into our novel devices. Examples include doped 2. Hendler, Netta, Elad Mentovich, Bálint Korbuly, Tamás Pusztai, László proteins, chiral nanostructures and plasmonic Gránásy, and Shachar Richter. Growth Control of Peptide-Nanotube materials. Spherulitic Films: Experiments and Simulations. Nano Research 8, Our compounds can be formed in self-assembly no. 11 (2015): 3630–38. fashion (the self-assembled monolayers of doped 3. Gordiichuk, Pavlo I, Dolev Rimmerman, Avishek Paul, Daniel A proteins), as thin films (white-emitting coating Gautier, Agnieszka Gruszka, Manfred Saller, Jan Willem de Vries, et for white LEDs) or as standalone materials al. ,Filling the Green Gap of a Megadalton Photosystem I Complex (biodegradable plastics and hydrogels made from by Conjugation of Organic Dyes. Bioconjugate Chemistry (2015). renewable materials). 4. Carmeli, Itai, Moshik Cohen, Omri Heifler, Yigal Lilach, Zeev Zalevsky, In order to explore the properties of these materials Vladimiro Mujica, and Shachar Richter. Spatial Modulation of we have developed new types of nano-devices, Light Transmission through a Single Microcavity by Coupling of including nano-vertical transistors and circuits, solar Photosynthetic Complex Excitations to Surface Plasmons.Nature cells and light emitting materials. We have also Communications (2015). developed novel nanolithography techniques, some 5. Beilis, Edith, Bogdan Belgorodsky, Ludmila Fadeev, Hagai Cohen, of which are currently undergoing commercialization and Shachar Richter. Surface-Induced Conformational Changes in processes. Doped Bovine Serum Albumin Self-Assembled Monolayers. Journal Our group includes students, postdocs and of the American Chemical Society 136, no. 17 (2014): 6151–54. engineers from various disciplines - including chemistry, physics, biology and engineering.
37 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Michael Gozin
Affiliation: Chemistry Email: [email protected] Web: https://en-exact-sciences.tau.ac.il/profile/cogozin
Research Title Research Description Chemistry of nitrogen-rich heterocycles and development of new My group focuses on the development of novel energetic materials energetic compounds and nanomaterials for various applications, including fire-extigushing Selected Publications: gas generators and materials for deep-well oil 1. Yan, Qi-Long; Trzcinski, Waldemar A.; Cudzilo, Stanislaw; Paszula, and gas extraction. We work on synthesis and Jozef; Eugen, Trana; Liviu, Matache; Traian, Rotariu; Gozin, Michael. comprehensive characterization of various nitrogen- Thermobaric effects formed by aluminum foils enveloping cylindrical rich heterocycles, related metal complexes, energetic charges. Combustion and Flame (2016), 166, 148-157. nanomaterials based on graphene oxide derivatives 2. Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi; Cohen, Adva; Pang, and energetic three-dimensional metal organic Si-Ping. Highly energetic compositions based on functionalized frameworks. carbon nanomaterials”, Nanoscale (2016), 8(9), 4799-4851. 3. Cohen, Adva; Yan, Qi-Long; Shlomovich, Avital; Aizikovich, Alexander; Petrutik, Natan; Gozin, Michael. Novel nitrogen-rich energetic macromolecules based on 3,6-dihydrazinyl-1,2,4,5-tetrazine. RSC Advances (2015), 5(129), 106971-106980. 4. Zeman, Svatopluk; Yan, Qi-Long; Gozin, Michael; Zhao, Feng-Qi; Akstein, Zbynek. Thermal behavior of 1,3,5-trinitroso-1,3,5-triazinane and its melt-castable mixtures with cyclic nitramines. Thermochimica Acta (2015), 615, 51-60. 5. Aizikovich, A.; Shlomovich, A.; Cohen, A.; Gozin, M.. The nitration pattern of energetic 3,6-diamino-1,2,4,5-tetrazine derivatives containing azole functional groups. Dalton Transactions (2015), 44(31), 13939-13946. 6. Ramishetti, Srinivas; Kedmi, Ranit; Goldsmith, Meir; Leonard, Fransisca; Sprague, Andrew G.; Godin, Biana; Gozin, Michael; Cullis, Pieter R.; Dykxhoorn, Derek M.; Peer, Dan. Systemic gene silencing in primary T lymphocytes using targeted lipid nanoparticlesACS Nano (2015), 9(7), 6706-6716.
38 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Chanoch Carmeli
Affiliation: Materials Science and Engineering Tel: 972-3- 6409826 Email: [email protected] Web: http://en-lifesci.tau.ac.il/profile/chanochc
Research Description Research Title The reaction center photosystem I (PSI) is a Nanotechnology of photosynthesis membrane protein-chlorophyll complex. PSI functions as a photodiode converting light Selected Publications: quanta into electrical charges of 1V at a quantum 1. Carmeli, I; Kumar, KS; Heifler, O; Carmeli, C., Naaman, R. Spin Selectivity efficiency of ~100%. We investigate the novel in Electron Transfer in Photosystem I. Agnew. Chem. Inter. Ed. 2014, properties of hybrid PSI-metals - metal nanoparticles, 53, (34) 8953-8958. semiconductors and nanotube devices, and study 2. H. Toporik, I. Carmeli, I. Volotsenko, M.Molotskii, Y. Rosenwaks, C. the interaction between PSI and the solids, and the Carmeli and N. Nelson, Large Photovoltages Generated by Plant efficiency of charge transfer through the fabricated Photosystem I Crystals. Adv. Mater. 2012, 24, 2988–2991. electronic junctions. 3. L. Sepunaru, I. Tsimberov, L. Forolov, C. Carmeli, I. Carmeli* and Oriented monolayers and multilayers of PSI are Y.Rosenwaks*, Picosecond Electron Transfer From Photosysnthetic self-assembled by forming a sulfide bond between Reaction Center Protein to GaAs Nano Lett. 2009, 9 (7) 2751-2755. metal surfaces and unique cysteine mutants of 4. L. Frolov, Y. Rosenwaks, S. Richter, C. Carmeli and I. Carmeli, genetically modified PSI from cyanobacteria. The dry Photoelectric Junctions Between GaAs and Photosynthetic Reaction layers generate photo potential. Covalent junctions Center Protein, , J. Phys. Chem. C. 2008, 112, 13426-13430. between the protein and the solid surface form 5. L. Frolov, O. Wilner, C. Carmeli and I. Carmeli, Fabrication of Oriented efficient electronic junctions that mediate charge Multilayers of Photosystem I Proteins on Solid Surfaces by Auto- transfer at a ps time scale. Oriented multilayers Metallization, Adv. Mater. 2008, 20, 263–266. are fabricated by autometalization, with cross linker molecules connecting the serial layers. When placed between metal and transparent electrodes, photovoltage and a photocurrent are generated. The oriented multilayers of PSI enhance the photovoltage and photocurrent, due to the serial arrangement of the dipoles and the enhanced absorption cross section. A surface photo potential of up to 100V was recorded in PSI crystals where hundreds of layers were serially oriented. Hybrids of carbon nanotubes and PSI are fabricated by activating the nanotubes and attaching the unique cysteine in the engineered protein through small bifunctional molecules. PSI that has cysteine on both the oxidizing and reducing ends of the protein forms junctions - either between nanotubes or between nanotubes and metal electrodes. The PSI in hybrid PSI-nanotube devices thus enhances the nonotubes’ photo conductance by an order of magnitude.
39 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Yossi Rosenwaks
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~yossir
Research Title Research Description Nanoscale electrical devices Prof. Rosenwaks leads a research group of 10 graduate students and scientists, and his current Selected Publications: research interests include: nanoscale electrical 1. Alex Henning, Nandhini Swaminathan, Andrey Godkin, Gil Shalev, measurements using mainly Kelvin probe force Iddo Amit, and Yossi Rosenwaks, Tunable diameter electrostatically- microscopy, nanowire transistors and sensors, charge formed nanowire for high sensitivity gas sensing, Nano Research, carrier dynamics and transport in semiconductors, DOI 10.1007/s 12274-01, (2015). and Kelvin probe microscopy of 2D materials. 2. A. Henning, M. Molotskii, N. Swaminathan, Y. Vaknin, A. Godkin, G. Shalev, and Y. Rosenwaks, Electrostatic Limit of Detection of Nanowire-based Sensors, Small, DOI: 10.1002/smll.201500566, (2015). 3. G. Segev, I. Amit, A. Godkin, A. Henning, and Y. Rosenwaks, Multiple State Electrostatically Formed Nanowire Transistors, IEEE Electron Device Lett. DOI: 10.1109/LED.2015.2434793, (2015). 4. I. Amit, N. Jeon, L. J. Lauhon, and Y. Rosenwaks, The Impact of Dopant Compensation on Graded p-n Junctions in Si Nanowires, ACS Applied Materials & Interfaces, 8 (1), pp 128–134, (2016). 5. Nandhini Swaminathan, Alex Henning, Yonathan Vaknin, Klimentiy Shimanovich, Andrey Godkin,Gil Shalev, and Yossi Rosenwaks, Dynamic Range Enhancement Using the Electrostatically Formed Nanowire Sensor, ACS Sensors, DOI: 10.1021/acssensors.6b00096.
40 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Tal Dvir
Affiliation: Life Sciences Email: [email protected] Web: dvirlab.tau.ac.il
Research Title Tissue engineering and regenerative medicine Research Description Our lab develops smart bio- and nanotechnologies Selected Publications: for engineering complex tissues. Our work focuses 1. Feiner R, Engel L, Fleischer S, Malki M, Gal I, Shapira A, Shacham- on engineering cardiac patches for treating patients Diamand Y, Dvir T. Engineered hybrid cardiac patches with after heart attacks, and on developing cyborg tissues multifunctional electronics for online monitoring and regulation that integrate micro- and nanoelectronics with living of tissue function. Nature Materials. 2016 Mar 14. doi: 10.1038/ organs to control their performance. nmat4590. 2. Baranes K, Shevach M, Shefi O, Dvir T. Gold Nanoparticle-Decorated Scaffolds Promote Neuronal Differentiation and Maturation. Nano Letters 2015 Dec 19. 3. Fleischer S, Miller J, Hurowitz H, Shapira A, Dvir T. Effect of fiber diameter on the assembly of functional 3D cardiac patches. Nanotechnology. 2015 Jul 24;26(29):291002.
41 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Alexander Golberg
Affiliation: Environmental Studies Email: [email protected] Web: http://www.tau.ac.il/~agolberg/
Research Title technologies — mostly problems with lignin— Bioengineering for sustainability and health raise questions regarding the actual potential of terrestrial biomass to meet the anticipated food, Selected Publications: feed and energy challenges in a sustainable way. 1. Towards marine biorefineries: Selective proteins extractions from An alternative source of biomass for biorefineries marine macroalgae Ulva with pulsed electric fields. Polikovsky, M, is offshore-grown macroalgae. Macroalgae have Fernand, F, Sack, M, Frey,W, Müller G, Golberg, A. Innovative Food been harvested throughout the world for centuries, Science & Emerging Technologies. 2016. both as a food source and as a commodity for the 2. Global potential of offshore and shallow waters macroalgal production of hydrocolloids. However, to date, biorefineries to provide for food, chemicals and energy: feasibility macroalgae still represent only a tiny percentage and sustainability, Lehahn Y, Ingle, K.N, Golberg A. Algal Research. of the global biomass supply: ~17∙10E6 tons fresh 2016. weight (FW) of macroalgae compared to 16∙10E11 3. Long-term Listeria monocytogenes proliferation control in milk tons of terrestrial crops, grasses and forests. A by intermittently delivered pulsed electric fields, implications for presently expanding body of evidence suggests food security in the low-income countries. Golberg, A. Technology. that offshore-cultivated macroalgae, which contain 3(1):1-6, 2015. very little lignin, and do not compete with food 4. Cloud-enabled microscopy and droplet microfluidic platform for crops for arable land or potable water, can provide specific detection of Escherichia coli in water. Golberg, A, Linshiz, an alternative source of biomass for the sustainable G, Kravets, I, Stawski, N, Hillson, N, Yarmush ML,Marks, RS, Konry, T. production of food, chemicals and fuels. Equal contributions. PLoS ONE 9(1): e86341.20. The goal of our laboratory is to develop a fundamental 5. Nanolayered siRNA Delivery Platforms for Local Silencing of understanding of energy flows in offshore marine CTGF Reduce Cutaneous Scar Contraction in Third-Degree Burns, biorefineries, to boost the net energy return on Castleberry, SA, Golberg, A, Abu Sharkh,M, Khan,S, Almquist, BD, investment, and to develop new technologies at Austen WG Jr., Yarmush,ML, Hammond, PT. Biomaterials. 2016. 14;95:2. the nano, micro and macro levels for implementing marine biorefineries for the benefit of humanity and Research Description society. To this end we are currently developing: Global population growth and a rising quality of life in the era of climate 1) a climate simulator in silica and experimentally; change are expected to increase the demand for food, chemicals and 2) technologies for algae breeding “from spore to fuels. A possible, sustainable direction for addressing this challenge is sea”, microdevices for studying seaweed-bacteria the production of biomass and the conversion of this biomass into the interactions; 3) a portfolio of computational and required products through a complex system known as a biorefinery. experimental tools for biomass deconstruction However, concerns over net energy balance, potable water use and and fermentation. environmental hazards, and uncertainty with regard to processing
42 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Judith Rishpon
Affiliation: Life Sciences Email: [email protected] Web: http://www.tau.ac.il/lifesci/departments/biotech/members/rishpon/rishpon.html
Research Title Bioelectrochemistry and biosensors Research Description Our research is centered on the fundamentals of Selected Publications: biological interactions at solid-liquid interfaces, 1. Bareket, L., Rephaeli, A., Berkovitch, G., Nudelman, A. & Rishpon .J. with emphasis on electrochemical biosensors. Carbon nanotubes based electrochemical biosensor for detection Sensors for medical diagnostics, environmental of formaldehyde released from a cancer cell line treated with pollution, food safety and veterinary uses were formaldehyde-releasing anticancer prodrugs. Bioelec (2011). developed. Modification of nanoparticles, such 2. Adler-Abramovich, L., Badihi-Mossberg, M., Gazit, E. & Rishpon, as carbon nanotubes, gold nanotubes or peptide J. (2010). Characterization of Peptide-Nanostructure-Modified nanoparticles significantly increases the sensitivity Electrodes and Their Application for Ultrasensitive Environmental of the sensors, enabling measurement of extremely Monitoring Small 6, 825-831. low concentrations. 3. Vernick, S.; Freeman, A.; Rishpon, J.; et al.(2011). Electro-hemical Biosensing for Direct Biopsy Slices Screening for Colorectal Cancer Detection. JOURNAL OF THE ELECTRO-CHEMICAL SOCIETY 1581 P1-P4. 4. Rishpon, Judith; Popovtzer, Rachela; Shacham-Diamand, Yosi; et al. (2012). Electrochemical methods of detecting colon cancer cells and use of same for diagnosing and monitoring treatment of the diseasePatent Number: US 08268577. Patent Assignee: Ramot 5. Rishpon, J.; Popovtzer, R.; Shacham-Diamand, Y.; et al. (2013) Electrochemical methods of detecting cancer with 4-aminophenyl phosphate. Patent Number: US 08530179.
43 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Noam Eliaz
Affiliation: Materials Science and Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~neliaz/
Research Title Research Description From corrosion in space to degradation in vivo and functionality The Biomaterials & Corrosion Laboratory at Tel of implants Aviv University strives to meet the demands of modern society by developing and studying Selected Publications: advanced materials for a variety of applications - in 1. N. Metoki, L. Liu, E. Beilis, N. Eliaz and D. Mandler. (2014) Preparation biomedicine, space, harsh environments and other and characterization of alkylphosphonic acid self-assembled areas. Following are some of the lab’s internationally monolayers on titanium alloy by chemisorption and electrochemical renowned achievements: deposition. Langmuir, 30(23), 6791-6799. 1) The development of a novel electrochemically- 2. H. Zanin, C. Rosa, N. Eliaz, P. May, F. Marciano and A. Lobo. (2015) deposited hydroxyapatite and other calcium Assisted deposition of nano-hydroxyapatite onto exfoliated carbon phosphate coatings for orthopedic and dental nanotube oxide scaffolds. Nanoscale, 7, 10218-10232. implants. Our current generation of coatings is 3. O. Levi, A. Shapira, B. Tal, I. Benhar and N. Eliaz. (2015) Isolating on its way to commercial use via collaboration epideral growth factor receptor overexpressing carcinoma cells with a manufacturer of dental implants, and we from human whole blood by Bio-Ferrography. Cytometry: Part are now working on future generations. These will B – Clinical Cytometry, 88, 136-144. incorporate biological matter and drugs to reduce 4. O. Levi, B. Tal, S. Hileli, A. Shapira, I. Benhar, P. Grabov and N. Eliaz. infections, increase osseointegration, and improve (2015) Optimization of EGFR high positive cell isolation procedure mechanical properties. In addition, self-assembled by Design of Experiments methodology. Cytometry: Part B – Clinical monolayers applied to the titanium substrate will Cytometry, 88, 338-347. enhance the strength of adhesion. 5. T. Nusbaum, B.A. Rosen, E. Gileadi and N. Eliaz. (2015) Effect of pulse 2) Electroplating and electroless plating of on-time and peak current density on pulse plated Re-Ni alloys. J. rhenium-based alloys. These projects, conducted Electrochem. Soc., 162(7), D250-D255. in collaboration with Prof. Eliezer Gileadi from the TAU School of Chemistry, and funded by the US AFOSR and Israel’s DoD, are intended mainly for aerospace, aircraft, and catalysis applications. Prof. Eliaz has studied the structure of such deposits at the atomic scale, using atom probe tomography (APT) and aberration-corrected transmission electron microscopy. 3) The magnetic isolation of biological matter for purposes of diagnosing diseases (such as cancer and osteoarthritis), determining the efficacy of drug treatment, and monitoring the wear of artificial joints - either at the design stage or during service in vivo. Ours is the only lab outside the US to have this capability, which is based on Bio-Ferrography.
44 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Oswaldo Dieguez
Affiliation: Materials Science and Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~dieguez/
Research Title Research Description Atomistic simulation of materials At the Atomistic Simulation of Materials group we research materials by computationally solving the Selected Publications: equations that their atoms follow. In this way we 1. Epitaxial phases of BiMnO3 from first principles; O. Diéguez and J. understand the properties of materials, perform Íñiguez: PHYSICAL REVIEW B 91, 184113 (2015). virtual experiments under conditions that are hard 2. Domain walls in a perovskite oxide with two primary structural to achieve in a real lab, and design new materials order parameters: first-principles study of BiFeO3; O. Diéguez, P. with tailored properties. Aguado-Puente, J. Junquera, and J. Iniguez: PHYSICAL REVIEW B We focus on ferroelectrics - materials with 87, 024102 (2013). technological applications in computer memories, 3. First-Principles Investigation of Morphotropic Transitions and Phase- sensors and actuators. We aim to advance the design Change Functional Responses in BiFeO3-BiCoO3 Multiferroic of ferroelectrics by understanding their properties SolidSolutions; O. Diéguez, and J. Iniguez: PHYSICAL REVIEW LETTERS and improving them. Current topics of interest at our 107, 057601 (2011). lab are ferroelectric domain walls and ferroelectrics 4. First-principles predictions of low-energy phases of multiferroic that show magnetic ordering (multiferroics). BiFeO3; O. Diéguez, O.E. Gonzalez-Vazquez, J. Wojdel, and J. Iniguez: We also study other materials in collaboration with PHYSICAL REVIEW B 83, 094105 (2011). experimentalists. Over the last two years we carried 5. The SIESTA method; developments and applicability; E. Artacho, E. out simulations in order to understand experiments Anglada, O. Diéguez, J.D. Gale, A. Garcia, J. Junquera, R.M. Martin, in the growth of transition metal silicide nano- P. Ordejon, M.A. Pruneda, D. Sanchez-Portal, and J. Soler: JOURNAL islands, learn about the structure of ReNi metallic OF PHYSICS-CONDENSED MATTER 20, 064208 (2008). alloys, and characterize the adsorption of polymers on metals in photovoltaic cells - to name several examples.
45 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Oded Hod
Affiliation: Chemistry Email: [email protected] Web: http://www.tau.ac.il/~odedhod/
Research Title Research Description Computational nanomaterials science Nanoscience and nanotechnology open a unique opportunity for applying highly accurate theories Selected Publications: to realistic material science problems. Research in 1. R. Pawlak, W. Ouyang, A. E. Filippov, L. Kalikhman-Razvozov, S. Kawai, my group focuses on the theoretical study of the T. Glatzel, E. Gnecco, A. Baratoff, Q. Zheng, O. Hod, M. Urbakh, and E. mechanical, electronic, magnetic and transport Meyer, Single Molecule Tribology: Force Microscopy Manipulation properties of systems at the nanoscale. Using of a Porphyrin Derivative on a Copper Surface, ACS Nano 10, 713- first-principles computational methods, we aim to 722 (2016). characterize both the ground state and dynamical 2. J. E. Peralta, O. Hod, and G. E. Scuseria, Magnetization Dynamics properties of such systems. From Time-Dependent Non-Collinear Spin Density Functional A combination of codes developed within our group, Theory Calculations, J. Chem. Theory Comput. 11, 3661-3668 (2015). along with commercial computational chemistry 3. T. Zelovich, L. Kronik, and O. Hod, Molecule-Lead Coupling at packages, operating on a highly parallelizable Molecular Junctions: Relation Between the Real- and State-Space high-performance computer cluster, allows us to Perspectives, J. Chem. Theory Comput. 11, 4861-4869 (2015). address the properties and functionality of a variety 4. D. Krepel, J. E. Peralta, G. E. Scuseria, and O. Hod, Graphene of systems, ranging from carefully tailored molecular Nanoribbons-Based Ultrasensitive Chemical Detectors, J. Phys. structures all the way to bulk systems. Chem. C 120, 3791-3797 (2016). In addition to questions of basic science, we 5. I. Oz, I. Leven, Y. Itkin, A. Buchwalter, K. Akulov, and O. Hod, Nanotubes pursue the design of technologically applicable Motion on Layered Materials: A Registry Perspective, J. Phys. Chem. nanoscale material properties, for future applications C 120, 4466-4470 (2016). in fields such as nano-electronics, nano-spintronics, accurate and sensitive chemical sensing and nano- mechanical devices.
46 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Amir Natan
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~amirn/
Research Title Research Description Multiscale simulations of materials and processes The goal of our lab is to develop and use multiscale models for materials, interfaces and processes for Selected Publications: energy applications. We also aim to bridge between 1. Natalia Kuritz, Michael Murat, Moran Balaish, Yair Ein-Eli, and Amir atomistic quantum and classical models and larger- Natan, PFC and Triglyme for Li-Air Batteries: A Molecular Dynamics scale continuum equations that will eventually allow Study – Journal of Physical Chemistry B (2016) DOI: 10.1021/acs. us to simulate a whole device. We develop formalism jpcb.5b12075. and code within the real-space PARSEC Density 2. Nicholas Boffi, Manish Jain and Amir Natan, Asymptotic behavior Functional Theory (DFT) and the time dependent and interpretation of virtual states: the effects of confinement and DFT (TDDFT) package, and aim to achieve very fast of basis sets – J. Chem. Phys. 144, 084104 (2016). calculations of FOCK exchange and post Hartree- 3. M. Zuzovski, A. Boag and A. Natan, Auxilliary grid method for the Fock methods for large systems. Combining DFT calculation of electrostatic terms in Density Functional Theory on and classical Molecular Dynamics (MD) we model a real-space grid, PCCP, 17, 31510, (2015). materials and processes for future batteries and 4. Yevgeny Rakita, Diana Golodnitsky, Amir Natan, Electrostatic photovoltaic applications. We also use machine potential of polyelectrolyte molecules grafted on charged surfaces: learning strategies and DFT to improve future MD A Poisson-Boltzmann model, Journal of Electrochemical Society simulations for such materials. Data mining strategies 161 (8), E3049-E3058, (2014). are used to search for and select new metal oxide 5. Amir Natan, Ayelet Benjamini, Doron Naveh, Leeor Kronik, Murilo materials, and to associate their structure with some L. Tiago, Scott P. Beckman,and James R. Chelikowsky, Real Space desired properties. Pseudopotential method for first principles calculations of general periodic and partially periodic systems, Phys. Rev. B 78, 075109 (2008).
47 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Michael Urbakh
Affiliation: Chemistry Email: [email protected] Web: www.tau.ac.il/~urbakh1/
Research Title • Describong thermal effects on nanoscale friction, Theory and simulations of friction at the nanoscale and understanding the origin of unexpected nonmonotonic dependence of nanoscale friction Selected Publications: on temperature 1. Urbakh M., Klafter J., Gourdon D., Israelachvili J., The nonlinear nature • Understanding the mechanism of wear and ripple of friction, Nature 430, 525-528 (2004). formation in nanoscale friction 2. Dudko O., Filippov A.E., Klafter J., Urbakh M., Beyond the conventional • Understanding the mechanism of onset of sliding description of dynamic force spectroscopy of adhesion bonds, motion for elastic sliders with extended rough Proc. National Academy of Sciences USA, 100, 11378–11381 (2003). interfaces 3. Ma M, Grey F., Shen L., Urbakh M., Wu S., Liu Z. J., Liu Y and Zheng • Bridging a gap between descriptions of friction Q. Water transport inside carbon nanotubes mediated by phonon- at the nano and macroscales induced oscillating friction, Nature Nanotech., 10, 692-696 (2015). • Developing novel methods for controlling friction 4. Ma M., Benassi A., Vanossi A., and Urbakh M., Critical Length Limiting using mechanics and chemistry Superlow Friction, Phys. Rev. Lett. 114, Art. 055501 (2015). A distinctive feature of research in the Michael 5. W. Ouyang, M. Ma, Q. Zheng, and M. Urbakh, Frictional Properties Urbakh group is the development of minimal of Nanojunctions Including Atomically Thin Sheets. Nano Letters, models which focus on a small number of the 16, 1878−1883 (2016). most relevant degrees of freedom of dynamical systems, but can nevertheless explain phenomena Research Description of high complexity. Moreover, the proposed minimal Since 1995, Michael Urbakh has been working on the theory of friction models have enabled predictions that were later at the nano and mesoscales. Frictional motion plays a central role in verified experimentally. A special highlight was diverse systems and phenomena that span a vast range of scales, from the remarkable prediction of the possibility of the nanometer contacts inherent in micro- and nano-machines and controlling friction mechanically via vibrations biological molecular motors, to the geophysical scales of earthquakes. of small amplitude and energy. Michael Urbakh The focus of research in the Michael Urbakh group is on a molecular demonstrated that manipulation by mechanical level description of processes occurring between interacting surfaces in excitations, when applied at the right frequency, relative motion, which is needed to first understand, and later manipulate, amplitude and direction, pulls the molecules out of friction. Important new results obtained by Michael Urbakh in this their potential energy minima and thereby reduces field include: friction (at other frequencies or amplitudes the • Understanding the mechanism of transition from stick-slip motion friction can be increased). This work stimulated to sliding experimental studies that confirmed the theoretical • Predicting and characterizing new regimes of frictional motion, in prediction, and recently this idea has been used by particular chaotic stick-slip and inverted stick-slip motion IBM in the development of the ultrahigh-density • Understanding the origin of a finite lifetime of superlubricity between data storage device Millipede. incommensurate surfaces, and suggesting novel ways to stabilize The theoretical approaches developed in the field the low-friction superlubric state of nanoscale friction led to breakthroughs in other • Describing friction in terms of rupture and formation of surface fields, such as single molecule force spectrosopcy junctions and molecular motors. In particular, Michael
48 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Urbakh developed a novel method for revealing molecular scale energy landscapes from the results of force unfolding experiments, which is now widely used in many experimental laboratories. Another development was a new approach to building microscopic engines on the nano and microscales, allowing efficient transformation of the fed energy into directed motion. These engines can move translationally or rotationally on surfaces, and perform useful functions such as pulling a nanoscale cargo.
49 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Haim Diamant
Affiliation: Chemistry Email: [email protected] Web: tau.ac.il/~hdiamant
Research Title Research Description Theory of complex fluids Our research group attempts to understand the structure and dynamic response of soft materials Selected Publications: and complex fluids using analytical models. Recent 1. Diamant, H. (2015). Response of a polymer network to the motion projects have included: instabilities in thin sheets, of a rigid sphere. Eur. Phys. J. 38, 32. dynamics of driven colloidal suspensions, and 2. Oshri, O., Brau, F., Diamant, H. (2015). Wrinkles and folds in a fluid- correlations in confined fluids. supported sheet of finite size. Phys. Rev. E 91, 052408. 3. Sonn-Segev, A., Blawzdziewicz, J., Wajnryb, E., Ekiel-Jezewska, M. L., Diamant, H., Roichman, Y. (2015). Structure and dynamics of a layer of sedimented Brownian particles. J. Chem. Phys. 143, 074704. 4. Oshri, O., Diamant, H. (2016). Properties of compressible elastica from relativistic analogy. Soft Matter 12, 664-668. 5. Goldfriend, T, Diamant, H., Witten, T. A. (2015). Hydrodynamic interactions between two forced objects of arbitrary shape: I Effect on alignment. Phys. Fluids 27, 123303.
50 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Diana Golodnitsky
Affiliation: Chemistry Email: [email protected] Web: http://www2.tau.ac.il/nano/researcher.asp?id=dbjhegflh
Research Title microsensors, self-powered integrated circuits or Nanomaterials and thin films for electrochemical energy storage microelectromechanical systems. Such devices and conversion need rechargeable microbatteries with dimensions on the scale of 1–10mm3, high energy density and Selected Publications: high power capability. 1. Moran Balaish, Emanuel Peled, Diana Golodnitsky and Yair Ein-Eli, A 3D concentric microbattery on a Si chip or Liquid-Free Lithium-Oxygen Batteries, Angewandte Communications, on 3D-printed polymer substrates enables the 54, 2 ,436–440 (2015) fabrication of a network of 10,000-30,000 units 2. E. Zygadło-Monikowska, Z. Florjańczyk, J. Ostrowska, E. Peled and D. connected in parallel, minimizing the ion-path Golodnitsky Synthesis and characterization of lithium-salt complexes length between the electrodes, and providing with difluoroalkoxyborates for application as lithium electrolytes. high capacity per footprint area. This is achieved Electrochimica Acta, 175, 104-112 (2015) by the insertion of four consecutive thin-film battery 3. K. Goldshtein, K. Freedman, D. Schneier, L. Burstein, V. Ezersky, E. layers into the high-aspect-ratio microchannels of Peled and D. Golodnitsky Advanced Multiphase Silicon-Based the perforated chip or polymer. For the first time, Anodes for High-Energy-Density Li-Ion Batteries, Journal of The the electrophoretic deposition (EPD) method is Electrochemical Society, 162 (6) A1072-A1079 (2015) exploited for the preparation of thin-film active 4. E. Peled, F. Patolsky, D. Golodnitsky, K.Freedman, G. Davidi, D. battery materials. Different solvents and surface- Schneier Tissue-like Silicon Nanowires-Based Three-Dimensional active agents are tested, with the aim of achieving Anodes for High-Capacity Lithium Ion Batteries, DOI: 10.1021/acs. well-dispersed nanoparticles in stable suspensions. nanolett.5b0074, Nano Lett., 2015 Such systems are controlled by the complex 5. R. Blanga, L. Burstein, M. Berman, S. G. Greenbaum, and D. interplay of concomitant phenomena, including Golodnitsky Solid Polymer-in-Ceramic Electrolyte Formed by micellization, association of the surfactant with Electrophoretic Deposition Journal of The Electrochemical Society, the polymer and adsorption of the surfactant on 162 (11) D3084-D3089,(2015) FOCUS ISSUE ON ELECTROPHORETIC the species. Of particular interest is the effect of DEPOSITION these cooperative interactions on the structure and 6. D. . Golodnitsky, E. Strauss, E. Peled, S. Greenbaum, Review—On Order ion-transport properties of polymer electrolytes and Disorder in Polymer Electrolytes Journal of The Electrochemical confined in the pores of ceramics. 3D-tomography Society, 162 (14) A1-A16 (2015) invited paper. tests (carried out in collaboration with Imperial 7. D. Golodnitsky , E. Strauss, T. Ripenbein, PSi-Based Supercapacitors College, London) provide the data sets for the in the book “Porous Silicon: From Formation to Application”, v.3 calculation of the tortuosity factor at sub-100nm Chapter 16, (2016), 345-372. resolution. To produce core-shell and multiphase ceramic/alkali-metal salt nanoparticles, the method Research Description of mechanochemistry is used. My major research activities focus on the synthesis and characterization of Very recent subjects under investigation include materials and the study of ion-transport phenomena in new nanostructured redox processes in a high-energy-density all- electrodes and solid electrolytes for energy-storage devices. solid-state lithiated Si/S battery (together with The microelectronics industry is continually reducing the size of its Prof. Emanuel Peled), and adsorption phenomena products in order to produce small devices such as medical implants, in supercapacitors based on porous silicon nanostructures.
51 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Gil Markovich
Affiliation: Chemistry Email: [email protected] Web: http://chemistry.tau.ac.il/markovich/
Research Title Research Description Colloidal nanomaterials The Markovich group is working on several types of nano-systems: Selected Publications: 1. Nanoscale chirality. Here we study the interaction 1. Amir Hevroni, Boris Tsukerman, Gil Markovich, Probing magnetization of chiral biomolecules with inorganic nanostructures dynamics in individual magnetite nanocrystals using magnetoresistive such as metal and semiconductor nanocrystals. scanning tunneling microscopy, Phys. Rev. B 92, 224423 (2015). These interactions may lead to induction of optical 2. Assaf Ben-Moshe, Sharon Grayer Wolf, Maya Bar Sadan, Lothar Houben, activity in plasmon and exciton resonances in the Zhiyuan Fan, Alexander O. Govorov, Gil Markovich, Enantioselective inorganic nanoparticles, and we are interested in control of lattice and shape chirality in inorganic nanostructures understanding the mechanism of such interactions. using chiral biomolecules, Nat. Comm. 5, 4302 (2014). We have also demonstrated that nanostructures of 3. Ben M. Maoz, Yulia Chaikin, Alexander B. Tesler, Omri Bar Elli, Zhiyuan materials like mercury sulfide, tellurium and selenium, Fan, Alexander O. Govorov, Gil Markovich, Amplification of Chiroptical which have crystal structures that are intrinsically Activity of Chiral Biomolecules by Surface Plasmons, Nano Lett. 13, chiral, can be synthesized enantioselectively 1203-1209 (2013). using chiral biomolecules such as cysteine and its 4. Daniel Azulai, Elad Cohen, Gil Markovich, Seed concentration control derivatives as surface stabilizers. of metal nanowire diameter, Nano Lett. 12, 5552-5558 (2012). 2. Magnetic nanoparticles. We have performed 5. Assaf Ben Moshe, Daniel Szwarcman, Gil Markovich, The size several studies involving magnetic nanocrystals.
dependence of chiroptical activity in colloidal quantum dots, ACS In particular, we worked with magnetite (Fe3O4) Nano 5, 9034–9043 (2011). nanocrystals and studied the magnetization dynamics of individual magnetite nanocrystals using a variable temperature STM. Using the same technique, we also studied the Verwey metal- insulator phase transition in individual magnetite nanocrystals at ~100K. Another project involving magnetic nanoparticles is the development of printable magnetic sensors based on nickel nanoparticle ink, together with Prof. Alexander Gerber’s group at TAU’s School of Physics. 3. Metal nanowire films as transparent electrodes. We are developing a simple wet chemical process for the preparation of thin gold/silver nanowire films, to be applied as transparent electrodes for various applications.
52 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Ori Cheshnovsky
Affiliation: Chemistry Email: [email protected] Web: http://www3.tau.ac.il/cheshnovsky/index.php
Research Title Label-free super-resolution microscopy Single nano-object spectroscopic microscopy Far-field super-resolution (SR) microscopy has become an important tool in life sciences. However, Selected Publications: it relies on, and therefore is limited by, the ability to 1. O. Tzang, A. Pevzner, R.E. Marvel, R.F. Haglund, O. Cheshnovsky(2015). control the fluorescence of label molecules. Super-Resolution in Label-Free Photomodulated Reflectivity, Nano We introduce a new far-field label-free SR Letters, 15, 1362. methodology that is based on the nonlinear 2. O. Tzang, O. Cheshnovsky (2015). New modes in label-free super response of the reflectance to photo-modulation. resolution based on photo-modulated reflectivity, Optics Express, It relies on the ability to photo-excite nonlinearly 23, 20926. spatial distribution of temperature and charge 3. T. Juffmann, A. Milic, M. Mullneritsch, P. Asenbaum, A. Tsukernik, J. carriers inside the diffraction-limited spot, by an Tuxen, M. Mayor, O. Cheshnovsky. M. Arndt. (2012). Real time single ultra-short pump pulse. An overlapping delayed molecule imaging of quantum interference.. Nature Nanotechnology, probe pulse monitors reflectance changes. Spatial 7 296-299. resolution within the diffraction-limited spot is 4. Z. Ioffe,, T. Shamai, A. Ophir, G. Noy, I. Yutsis, K. Kfir, O. Cheshnovsky, enhanced due to nonlinearities in photo-modulated Y. Selzer.(2008). Detection of heating in current carrying molecular properties of the matter. The method is suitable junctions by Raman scattering,Nature Nanotechnology 3, 727. for characterizing semiconductors and metals in 5. E. Flaxer, O. Sneh and O. Cheshnovsky. (1993) Molecular light emission vacuum, ambient and liquid semi-transparent induced by inelastic electron tunneling. Science 262, 2012-2014. and opaque systems, ultrathin and thick samples alike. The fast response of the basic methodology Research Description (picoseconds) will enable video rate scanning laser Single nano-object spectroscopic microscopy nanoscopy. Single-molecule spectroscopic detection in fluorescent microscopy is We have demonstrated several examples of such already well established. However, not all molecules of interest fluoresce. resolution enhancement due to nonlinearities: In our laboratory we are developing a new approach to measuring the The change of thermo-reflectance of VO2 upon light absorption of single nano-objects, including single molecules. We its characteristic insulator-to-metal transition at use a supercontinuum laser (Fianium) and an Acousto Optical Tunable ~340K, the heating process of nanostructured silicon Filter to select the wavelength. The absorption detection is then carried or gold surfaces, and the nonlinear response of out by an auto-balanced photodiode-pair aimed to suppress the laser photo-modulated Raman spectra. Resolution down noise, and a lock-in detection of a special absorption modulation to 85nm is demonstrated. Based on similar ideas we technique. This is critical for enabling the detection of light absorbed by focus on improving current SR methods intended a single particle in the order of 10-4-10-7, which is orders of magnitude for the biomedical research community. smaller than the intensity fluctuations of the light source. One of our long-term scientific goals is to characterize the spectroscopic properties of specially designed Si/Ge core shell nanowires (fabricated by our collaborators in the Patolsky lab), which according to theoretical predictions by A. Zunger are characterized by a direct band gap. In other projects we monitor the interaction between localized plasmons and excitons in WS2 nanorods.
53 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Emanuel Peled
Affiliation: Chemistry Email: [email protected] Web: nano.tau.ac.il/peled
Research Title Research Description Nanomaterials and thin films for electrochemical energy storage Our research focuses on the development and and conversion characterization of novel and improved batteries. We have developed a molten-sodium/air battery Selected Publications: operating at above the melting point of sodium 1. H. Mazor, D. Golodnitsky, L. Burstein, A. Gladkich, E. Peled, (97.8oC). This battery, in addition to eliminating Electrophoretic deposition of lithium iron phosphate cathode for dendrite formation, can accelerate sluggish cathode thin-film 3D-microbatteries, Journal of Power Sources 198, (2012) reactions and lower cell impedance. We explored 264-272. the key parameters that affect the performance of 2. K. Goldshtein, D. Golodnitsky E. Peled, L. Adler-Abramovich, E. Gazit, S. the electrodes and their impact on the operation Khatun, P. Stallworth, S. Greenbaum. Effect of peptide nanotubeller on of the molten-Na/air cell in glymes, PYR14TFSI ionic structural and ion-transport properties of solid polymer electrolytes liquid and polyethylene oxide-based electrolytes. Solid State Ionics 220 (2012) 39–46 We have developed a very active oxygen reduction 3. E. Peled. Development and Characterization of Composite YSZ-PEI reaction (ORR). By using a core-shell nanostructure Electrophoretically Deposited Membrane for Li-Ion Battery, J Phys. concept, we were able to reduce the amount of Chem. B, 117 (2013) (6), 1577–1584 platinum, while at the same time increasing the 4. E. Peled, D. Golodnitsky, R. Hadar, H. Mazor, M. Goor and L Burstein, activity of the ORR catalysts. Challenges and Obstacles in the Development of Sodium-Air We have succeeded in the development of anodes Batteries, Journal of Power Sources 244 (2013) 771-776 made of silicon nanowires and silicon nanoparticles 5. E. Peled, D. Golodnitsky, R. Hadar, H. Mazor, M. Goor and L Burstein, coated with protective layers. These anodes Challenges and Obstacles in the Development of Sodium-Air demonstrate excellent performance that meets Batteries, Journal of Power Sources 244 (2013) 771-776 the requirements of lithium batteries for portable and electric-vehicle applications. We investigate the impact of cathode design, type of electrolyte and type of cathode binder on the cathode reactions and on battery performance of lithium-sulfur batteries. Additionally, we investigate hybrid double-layer capacitors (HDLCs) that offer at least five times more energy density than water-based double- layer capacitors (DLC).
54 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Abraham Nitzan
Affiliation: Chemistry Email: [email protected] Web: http://atto.tau.ac.il/~nitzan/nitzan.html
Research Title Research Description Theoretical aspects of chemical dynamics Research in my group focuses on theoretical aspects of chemical dynamics. This branch of chemistry Selected Publications: describes the nature of physical and chemical 1. A. Migliore and A. Nitzan, Irreversibility in redox molecular conduction: processes underlying the progress of chemical single versus double metal-molecule interfaces Electrochimica reactions, with the aim of understanding such Acta 160, 363–375 (2015). processes and being able to predict their course 2. K. Kaasbjerg and A. Nitzan, Theory of light emission from quantum of evolution. In particular, our studies deal with noise in plasmonic contacts: above-threshold emission from higher- chemical processes involving interactions between order electron-plasmon scattering, Phys. Rev. Letters, 114, 126803 light and matter, chemical reactions in condensed (2015). phases and at interfaces, and transport phenomena 3. W. Dou, A. Nitzan and J. E. Subotnik, Surface hopping with a manifold in complex systems. Our main research emphases of electronic states. II. Application to the many-body Anderson- are: Holstein model, J. Chem. Phys. 142, 084110 (2015). • Energy transfer processes in molecular systems 4. K. Kaasbjerg and A. Nitzan, Theory of light emission from quantum • Molecular dynamics in condensed phases noise in plasmonic contacts: above-threshold, emission from higher- • Ionic transport in complex environments order electron-plasmon scattering, Phys. Rev. Letters, 114, 126803 • Optical properties and photochemistry of (2015) adsorbed molecules 5. W. Dou, A. Nitzan and J. E. Subotnik, Surface hopping with a manifold • Electron transport through molecular layers and of electronic states, III: transients, broadening and the Marcus picture, wires J. Chem. Phys. 142, 234106 (2015). • Classical and quantum thermodynamics of energy conversion processes
55 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Roey J. Amir
Affiliation: Chemistry Email: [email protected] Web: http://chemistry.tau.ac.il/roeyamir/
Research Title Research Description Smart polymers Stimuli-responsive nanocarriers that can disassemble to release their encapsulated cargo upon external Selected Publications: stimuli have gained increasing attention due to their 1. Harnoy, Assaf J.; Rosenbaum, Ido; Tirosh, Einat; Ebenstein, Yuval; possible utilization as smart drug delivery systems. Shaharabani, Rona; Beck, Roy; Amir, Roey J., Enzyme-Responsive Among the various types of stimuli, enzymes offer Amphiphilic PEG-Dendron Hybrids and Their Assembly into Smart great potential for the activation of biomedical Micellar Nanocarriers, Journal of the American Chemical Society carriers, due to their overexpression in various (2014), 136, 7531-7534. diseases. The design of enzyme-responsive block 2. Rosenbaum, Ido; Harnoy, Assaf J.; Tirosh, Einat; Buzhor Marina; Segal, copolymers is highly challenging, as the enzyme Merav; Frid, Liat; Shaharabani, Rona; Avinery, Ram; Beck, Roy; Amir, must reach the enzyme-sensitive moieties - which Roey J., Encapsulation and covalent binding of molecular payload are spread along the backbone of the polymer, and in enzymatically activated micellar nanocarriers, Journal of the might be hidden inside the hydrophobic cores of the American Chemical Society (2015), 137, 2276-2284. self-assembled structures. The polydispersity of the 3. Buzhor, Marina; Harnoy, Assaf J.; Tirosh, Einat; Barak, Ayana; Schwartz, stimuli-responsive block raises another significant Tal; Amir, Roey J., Supramolecular translation of enzymatically challenge for the kinetic analysis and mechanistic triggered disassembly of micelles into tunable fluorescent responses, study of the enzymatic response, as the enzyme’s Chemistry - A European Journal (2015), 21, 15633–15638. access to the enzymatically activated moieties can 4. Amir, Roey J., Enzyme-Responsive PEG-Dendron Hybrids as Platform vary greatly - depending on their location along the for Smart Nanocarriers, Synlett (2015), 26 (19), 2617-2622. polymer backbone, the length of the polymer chain, 5. Buzhor, Marina; Avram, Liat; Frish, Limor; Cohen, Yoram; Amir, Roey and its solubility. To address these challenges, we J., Fluorinated Smart Micelles as Enzyme-responsive Probes for are developing highly modular polymeric platforms 19F-Magnetic Resonance, Journal of Materials Chemistry B (2016), based on amphiphilic PEG-dendron hybrids. These Advance Article DOI: 10.1039/C5TB02445E. amphiphilic hybrids can self-assemble in water into micellar nanocontainers that disassemble and release encapsulated molecular cargo upon enzymatic activation. The modularity of these PEG- dendron hybrids offers great control and tuning of the disassembly rate of the formed micelles, through simple adjustment of the PEG’s length. Such smart amphiphilic hybrids could open the way for the fabrication of nanocarriers with tunable release rates for drug delivery applications.
56 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Dan Peer
Affiliation: Life Sciences Email: [email protected] Web: http://www3.tau.ac.il/danpeer/
Research Title Research Description Nanomedicine Our lab searches for ways to manipulate cells’ functions in order to generate novel strategies Selected Publications: for the treatment of inflammatory diseases and 1. S. Weinstein, I.A. Toker, R. Emmanuel, S. Ramishetti, I. Hazan-Halevy, cancers. In addition, we develop nanomedicines D. Rosenblum, M. Goldsmith, A. Abrahamc, O. Benjamini, O. Bairey, by designing highly selective targeting moieties P. Raanani, A. Nagler, J. Liebermane,and D. Peer. (2016) Harnessing and novel nanocarriers. Work at the lab is based RNAi based-nanomedicines for therapeutic gene silencing in B cell on a multidisciplinary approach, which combines malignancies. Proc. Natl. Acad. Sci. USA 113(1) E16-E22. immunology, cell and molecular biology, 2. Dearling, J., Daka, A., Veiga, N., Peer, D., and Packard A. (2016) genetics, protein engineering, material sciences, ImmunoPET of colitis: defining target cell populations and optimizing nanotechnology and computational techniques. pharmacokinetics. Inflammatory Bowel Diseases. 22(3):529-538. Our ultimate goal is translating some of our findings 3. Ramishetti S., Kedmi R., Goldsmith M., Leonard F., Speague AG., into drugs and therapeutics for clinical settings. Godin B., Gozin M., Cullis P., Dykxhoorn DM., and Peer D (2015) We are particularly interested in: Systemic Gene Silencing in Primary T lymphocytes using Targeted • Developing novel strategies for targeted drug Lipid Nanoparticles. ACS Nano. delivery 4. Cohen ZR, Ramishetti S, Peshes-Yaloz N, Goldsmith M, Wohl A, • Probing and manipulating the immune system Zibly Z, and Peer D (2015). Localized RNAi Therapeutics of Chemo- with nanomaterials Resistant Grade IV Glioma using Hyaluronan-Grafted Lipid-Based • Developing non-invasive theranostic systems for Nanoparticles. ACS Nano. 9(2), 1581-1591. inflammatory bowel diseases and blood cancer 5. Singh M.S., Peer D. (2016) RNA nanomedicines: the next generation • Studying the role of cell cycle regulators during drugs? Current Opinion in Biotechnology 28-34. inflammatory bowel diseases and blood cancers • Investigating novel cancer multidrug resistance inhibitors • Studying novel approaches to target adult stem cells (hematopoietic, bulge, cancer) • Harnessing RNAi as a tool for drug discovery and therapeutic applications • Developing tools to study immuno-nanotoxicity • Investigating polysaccharides as building blocks for nanotherapeutics
57 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Ronit Satchi-Fainaro
Affiliation: Medicine Tel: 972-3-6407427 Email: [email protected] Web: http://medicine.mytau.org/satchi-fainaro/
Research Title Research Description Cancer angiogenesis and nanomedicine research Our research focuses on the field of nanomedicine and angiogenesis (cancer and vascular biology). Selected Publications: We have major expertise in tumor biology, tumor 1. Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek dormancy, angiogenesis, molecular imaging, non- P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, invasive intravital imaging of animal models and Aviel-Ronen S, Barshack I, Calderón M, Haag R and Satchi-Fainaro R, personalized nanomedicines for cancer theranostics Identification of Dormancy-Associated MicroRNAs for the Design (therapy and diagnostics). Throughout our work of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes, we have maintained an interest in understanding ACS Nano 10(2): 2028-2045 (2016). the biological rationale for the design of 2. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, nanomedicines suitable for transfer to clinical Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer testing. Our multidisciplinary laboratory focuses Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501. on basic research elucidating the mechanisms 3. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, underlying the switch from dormancy, leading to Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer the discovery of new molecular targets interrupting Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501. tumor-host interactions. This research is followed by 4. Fisusi FA, SiewPHARMACEUTICAL_Cover A, Chooi KW, Okubanjo the design of highly-selective targeting molecules O, Garrett N, Lalatsa K, Serrano D, Summers I, Moger J, Stapleton P, integrating biology, chemistry, protein engineering, Satchi-Fainaro R, Schätzlein AG, Uchegbu IF, Lomustine Nanoparticles molecular imaging, computational approaches, Enable Both Bone Marrow Sparing and High Brain Drug Levels – A material sciences and nanotechnology, to selectively Strategy for Brain Cancer Treatments, Pharmaceutical Research guide drugs into pathological sites. 33(5):1289-1303 (2016). 5. Redy-Keisar O, Ferber S, Satchi-Fainaro R, Shabat D. NIR Fluorogenic Dye as a Modular Platform for Prodrug Assembly: Real-Time in vivo Monitoring of Drug Release. ChemMedChem. 2015 10(6):999-1007.
58 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Inna Slutsky
Affiliation: Medicine Email: [email protected] Web: http://www.slutskylab.com/
Research Title Research Description Neuronal plasticty The long-term goal of our study is to understand cellular, molecular and network-wide mechanisms Selected Publications: underlying the transition from normal brain 1. Gazit, N., Vertkin, I., Shapira, I., Helm, M., Slomowitz, E., Sheiba, M., physiology to Alzheimer’s disease (AD) pathology. Mor, Y., Rizzoli, S., and Slutsky, I. (2016) IGF-1 Receptor Differentially Utilizing an integrated system that combines FRET Regulates Spontaneous and Evoked Transmission via Mitochondria spectroscopy / 2photon-FLIM, high-resolution at Hippocampal Synapses, Neuron 89, 583-597. optical imaging, electrophysiology, molecular 2. Frere, S. and Slutsky, I. (2016) Targeting PTEN interactions for biology and biochemistry, we explore the casual Alzheimers disease, Nature Neuroscience 19, 416-418. relationships between ongoing neuronal activity, 3. Vertkin, I., Styr, B., Slomowitz, E., Ofir, N., Shapira, I., Berner, D., Fedorova, structural rearrangements within synaptic signaling T., Laviv, T., Barak-Broner, N., Greitzer-Antes, D., Gassmann, M., Bettler, complexes and plasticity of individual neurons, and B., Lotan, I., and Slutsky, I. (2015) GABAB receptor deficiency causes the whole neural network. This integrated system failure of neuronal homeostasis in hippocampal networks, Proc Natl has enabled us to identify new principles and novel Acad Sci U S A 112, E3291-3299. molecular targets that critically influence synaptic 4. Slomowitz, E., Styr, B., Vertkin, I., Milshtein-Parush, H., Nelken, I., Slutsky, and memory functions, initiating AD-associated M., Slutsky, I. (2015). Interplay between population firing stability synaptic dysfunctions. Specifically, we have and single neuron dynamics in hippocampal networks. Elife 4. identified hyperactivity of excitatory hippocampal synapses as a primary mechanism initiating synaptic dysfunctions, and have also found the mechanism underlying these synaptic changes. We believe that the integrated system we have developed to measure structure-function relationships at the single synapse level may contribute to a better understanding of the initiation of AD-related neuronal and synaptic dysfunctions, ultimately leading to a new therapeutic approach by reversing hippocampal hyperactivity in Alzheimer’s patients.
59 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Rimona Margalit
Affiliation: Life Sciences Email: [email protected] Web: none
Research Title Research Description Biomaterial-based targeted carriers for theranostics of cancer Our group applies three lipid-based particulate and inflammation drug carriers for theranostics of major pathology classes - all invented and developed ‘in-house’. Selected Publications: Four such projects are currently running at the 1. Ben-Mordechai T, Palevsky D, Glucksam-Galnoy Y, Elron-Gross I, lab, and each project includes three stages: (i) Margalit R, Leor J (2015) Targeting Macrophage Subsets for Infarct Formulation studies – making the drug-carrier Repair. 2015). Targeting Macrophage Subsets for Infarct Repair. systems and characterizing them through structural Journal of Cardiovascular Pharmacology and Therapeutics 20, 36-51. and physicochemical studies; (ii) In vitro studies 2. Ilia Rivkin, Yifat Galnoy-Glucksam, Inbar Elron-Gross, Amichay Afriat, in cultures of the relevant target and control cell Arik Eisenkraft, Rimona Margalit (2016) Treatment of respiratory lines, pursuing safety and retention of therapeutic damage in mice by aerosols of drug-encapsulating targeted lipid- activity of the carrier-encapsulated drug; and (iii) In based particles. Journal of Cont. Rel. in publication, on line April 2016 vivo studies in appropriate animal models, pursuing 3. Rimona Margalit and Dan Peer (2016). Lipidated glycosaminoglycan safety and efficacy. particles and their use in drug and gene delivery for diagnosis and Our current projects include: therapy. US patent # 9,259,474 1) Inhalational treatment of respiratory damage by aerosols of hyaluronan-liposomes encapsulating anti-inflammatory and anti-oxidant drugs - a single drug or both in the same liposome. This is currently at the in vivo stage, evaluating safety and efficacy in a mouse model for acute lung inflammation. 2) Theranostics of heart inflammation (post myocardial infarction) by macrophage-targeted liposomes encapsulating iron nanoparticles, iron complexes or steroids. This project, conducted in collaboration with Prof. J. Leor from TAU’s Faculty of Medicine, is currently at the in vitro and in vivo stages. 3) Cancer theranostics, directed at both the cancer cells and the tumor-associated macrophages, by hyaluronan-liposomes encapsulating iron complexes. This study, also in collaboration with Prof. J. Leor, is now at the in vitro and in vivo stages. 4) Treatment of osteoarthritis via local injection, by a collagen-based carrier encapsulating anti- inflammatory drugs. This is in the initial stage of formulation studies.
60 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Ehud Gazit
Affiliation: Molecular Microbiology and Biotechnology Department Email: [email protected] Web: https://en-lifesci.tau.ac.il/profile/ehudg
Research Title Research Description Molecular self-assembly of biological, bio-inspired and other The work in our group focuses on the molecular organic building blocks self-assembly of biological, bio-inspired and other organic building blocks, a key process in chemistry Selected Publications: and biochemistry. We apply a minimalistic approach 1. Fichman, G., Guterman, T., Damron, J., Adler-Abramovich, L., Schmidt, to define the smallest molecular recognition J., Kesselman, E., Shimon, L.J., Ramamoorthy, A., Talmon, Y., Gazit, E. and assembly modules, and understand the (2016). Spontaneous structural transition and crystal formation in physicochemical basis for their association. We minimal supramolecular polymer model. Science Adv. 2, e1500827. study the organization of biological systems in 2. Berger, O., Adler-Abramovich, L., Levy-Sakin, M., Grunwald, A., diverse fields, including amyloid diseases such as Liebes-Peer, Y., Bachar, M., Buzhansky, L., Mossou, E., Forsyth, V.T., Alzheimer’s disease and Parkinson’s disease, diabetes, Schwartz, T., Ebenstein, Y., Frolow, F., Shimon, L.J.W., Patolsky, F., viral diseases and metabolic disorders. We have Gazit, E. (2015). Light-Emitting Self-Assembled Peptide Nucleic identified the ability of very short peptides, as well Acids Exhibit Both Stacking Interactions And Watson-Crick Base as metabolites, to form typical amyloidal nano- Pairing. Nature Nanotech. 10, 353-360. fibrils. Our study of minimal recognition modules 3. Mondal, S., Adler-Abramovich, L., Lampel, A., Bram, Y., Lipstman, S., has led to the discovery of a family of dipeptide Gazit, E. (2015). Formation Of Functional Super-Helical Assemblies nanostructures of various architectures, including By Constrained Single Heptad Repeat. Nature Commun. 6, 8615. nanotubes, nanospheres, nanoplates and hydrogel, 4. Levin, A., Mason, T.O., Adler-Abramovich, L., Buell, A.K., Meisl, G., with nanoscale order and unique mechanical, optical, Galvagnion, C., Bram, Y., Stratford, S.A., Dobson, C.M., Knowles, piezoelectric and semiconductive properties. These T.P.J., Gazit, E. (2014). Ostwald’S Rule Of Stages Governs Structural various assemblies form from remarkably simple Transitions And Morphology Of Dipeptide Supramole. building blocks that can potentially be synthesized 5. Adler-Abramovich, L., Vaks, L., Carny, O., Trudler, D., Magno, A., Caflisch, in large quantities at a low cost. We demonstrated A., Frenkel, D., Gazit, E. (2012). Phenylalanine Assembly Into Toxic how these peptide nanostructures can be used Fibrils Suggests Amyloid Etiology In Phenylketonuria. Nature Chem. as casting molds for the fabrication of metallic Biol. 8, 701-706. nano-wires and coaxial nanocables. We used inkjet technology as well as vapor deposition methods to coat surfaces and form peptide “nano-forests” in a highly controlled manner. We are currently employing microfluidic techniques to enable the formation of assembled products with specific size distribution, while controlling the assembly kinetics. We recently extended our studies to peptide nucleic acids (PNA), thereby converging the fields of peptide nanotechnology and DNA nanotechnology.
61 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Tal Ellenbogen
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~tal/neolab/
Research Title Research Description Nanoscale light-matter interaction We study the fundamentals of the interaction between light and matter at the nanoscale, in order Selected Publications: to gain a better understanding of the underlying 1. N. Segal, S. Keren-Zur, N. Hendler, T. Ellenbogen, Controlling light with physical mechanisms of this interaction, and use metamaterial-based nonlinear photonic crystals, Nature Photonics it to develop the next generation of optical and 9, 180-184(2015). electro-optical devices. 2. E. Eizner, O. Avayu, R. Ditcovski, T. Ellenbogen, Aluminum Nanoantenna Our research involves: extensive fabrication and Complexes for Strong Coupling between Excitons and Localized design of novel nanostructured materials for optical Surface Plasmons, Nano Letters 15, 6215-6221(2015). and electro-optical applications; characterization 3. O. Avayu, O. Eisenbach, R. Ditcovski and T. Ellenbogen, Optical of the interaction of these materials with laser Metasurfaces for Polarization Controlled Beam Shaping, Optics beams and incoherent light; and the development Letters 39, 3892-3895 (2014). of relevant analytical or numerical models and 4. Marcel Rey, Roey Elnathan, Ran Ditcovski, Karen Geisel, Michele simulations. Zanini, Miguel A Fernandez-Rodriguez, Vikrant V. Naik, Andreas The lab’s active lines of research and development Frutiger, Walter Richtering, Tal Ellenbogen, Nicolas H. Voelcker, and currently include: stimulated emission effects in nano- Lucio Isa, Fully Tunable Silicon Nanowire Arrays by Soft complexes; emission control and synchronization for 5. Shay Keren-Zur, Ori Avayu, Lior Michaeli, and Tal Ellenbogen Nonlinear optical computing and lab-on-a-chip applications; beam shaping with plasmonic metasurfaces, ACS Photonics 3, nonlinear plasmonic metamaterials for optical wave 117-123 (2016). mixing applications; hybrid light-matter excitations based on strongly coupled exciton-plasmon- polaritons and waveguide-exciton-polaritons as means for developing all-optical and electro- optical switches, coherent light sources and optical amplifiers; optical elements based on metamaterials and nano-antennas for consumer electronics and imaging devices; and new structured surfaces for interferometric microscopy.
62 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Jacob Scheuer
Affiliation: Electrical Engineering Email: [email protected] Web: www.eng.tau.ac.il/~kobys/
Research Title Research Description Nano-photonic devices and applications Nano-Photonics deals with the interaction of light and matter at the nanoscale. This research field is Selected Publications: of fundamental scientific importance, while also 1. G. Kaplan, K. Aydin and J. Scheuer, Dynamically controlled plasmonic providing a main route to novel technologies nano-antenna phased array utilizing vanadium dioxide, Opt. Mater. and applications - such as sensing, solar energy Express 5, 2513-2524 (2015). (Invited). harvesting, telecommunications and optical 2. E. Ben Bassat and J. Scheuer, Optimal design of radial Bragg cavities computing. and lasers, Opt. Lett. 40, 3069-3072 (2015). Specifically in our lab we focus on the development 3. M. Eitan, Z. Iluz, Y. Yifat, A. Boag, Y. Hanein, and J. Scheuer, Degeneracy of nano-antennas for optical frequencies, which have Breaking of Wood’s Anomaly for Enhanced Refractive Index Sensing, applications in many different areas: solar energy ACS Photon. 2, 615−621 (2015). harvesting, controlled self-assembly and beam 4. D. Bar-Lev, A. Arie, J. Scheuer, and I. Epstein, Efficient excitation and shaping, nano semiconductor lasers for sensing and control of arbitrary surface plasmon polariton beams using one- telecommunications, and secure communications dimensional metallic gratings, J. Opt. Soc. Am. B 32, 923-932 (2015). using fiber lasers and polymer optics. 5. J. Scheuer and Y. Yifat, Metasurfaces make it practical, Nature Nanotech. 10, 296-298 (2015).
63 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Yossi Lereah
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~lereah/
Research Title Research Description Application of TEM in quantum mechanics Recent progress in the fabrication of artificial structures at the nanometer scale enable us to Selected Publications: transform the established knowledge from light 1. Noa Voloch-Bloch, Yossi Lereah, Yigal Lilach, Avraham Gover and Ady optics into electron beams. The transmission Arie Generation of electron Airy beams, Nature, 494 331-335,(2013). electron microscope contains the required optical 2. A. Be’er, R. Kofman, F. Phillipp and Y. Lereah, Spontaneous element. However, the commercial systems are crystallographic instabilities of Pb nanoparticles in a SiO matrix, constructed for microscopy. Accordingly, it is Physical Review B 76 075410 (2007). necessary to modify the operation of the microscope 3. Y. Lereah, R. Kofman, J.M. Penisson, G. Deutscher, P. Cheyssac, T. Ben via various methods, e.g. free lens control. David and A. Bourret, Time Resolved Electron Microscopy Studies of the Structure of Nanoparticles and Their Melting, Philosophical Magazine (invited paper), 81, 1801 (2001). 4. Y. Lereah, Pattern Formation and Interface Propagation in the Crystallization of Amorphous Alloys, Current Topics in Crystal Growth 7, 59 (2004). Invited paper. 5. Y. Lereah, E. Grunbaum and G. Deutscher, Formation of Dense Branching Morphology in the Crystallization of Al:Ge Amorphous Thin Films. Physical Review A 44 8316 (1991).
64 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Alon Bahabad
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~alonb/
Research Title Research Description Physical optics Our group is interested in theoretical and experimental research in various areas of physical Selected Publications: optics. One of our major areas of research is the 1. Itai Hadas and Alon Bahabad, Macroscopic manipulation of high- generation of coherent light sources at very high harmonic-generation through bound-state coherent control, Physical photon energies (soft X-rays). For this we employ the Review Letters, 113, 253902 (2014). extreme nonlinear optical process of high-harmonic- 2. Yaniv Eliezer and Alon Bahabad, Super-transmission: The delivery of generation (HHG). HHG is driven with an intense superoscillations through the absorbing resonance of a dielectric ultra-short light pulse which ionizes a gaseous medium, Optics Express, 22, 31212-31226 (2014). medium. The liberated electron then oscillates in 3. Mor Konsens and Alon Bahabad, Time-to-frequency mapping of the laser field, gaining kinetic energy. There is a optical pulses using accelerating quasi-phase-matching, Physical small chance that the electron will encounter the Review A, 93, 023823 (2016). ion from which it has been liberated and recombine 4. Alon Bahabad, Margaret M. Murnane and Henry C. Kapteyn, Quasi with it. The excessive kinetic energy gained by the Phase Matching of Momentum and Energy in Nonlinear Optical electron is released in the form of a high energy Processes, Nature Photonics, 4, 570-575 (2010). photon. During such a process hundreds of photons 5. Ron Lifshitz, Ady Arie and Alon Bahabad, Photonic quasicrystals for in the laser field can be converted into a single general purposes nonlinear optical frequency conversion, Physical high-energy photon. We are interested in mediating Review Letters, 95, Issue 13, 133901 (2005). this process by employing Plasmon-assisted field enhancement. When the laser light interacts with a metallic nanostructure, electron oscillations on the metal surface can lead to a significant field enhancement. This can be utilized to assist with the process of HHG. In addition, the geometry of the metallic nanostructure can be used to control the beam shape and polarization state of the generated high harmonic radiation.
65 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. David J. Bergman
Affiliation: Physics Email: [email protected] Web: http://www2.tau.ac.il/nano/researcher.asp?id=abddjgchk
Research Title Research Description Physical phenomena in composite media The research in our group focuses on the followings: 1. Magneto-transport and magneto-optics in metal- Selected Publications: dielectric composite media, when the Hall resistivity 1. D. J. Bergman, Perfect imaging of a point charge in the quasistatic in the metallic constituent is greater than the Ohmic regime, Phys. Rev. A 89, 015801 (4 pp.) (2014). resistivity 2. D. J. Bergman and Y. M. Strelniker, Strong-field magneto-transport 2. Nano-plasmonics in such a medium in a two-constituent columnar composite medium where the 3. Macroscopic physical phenomena in social constituents have comparable resistivity tensors, Phys. Rev. B 86, wasps: the exploitation of thermoelectric cooling 024414 (14 pp.) (2012). to regulate the body temperature of the Oriental 3. M. Tornow, D. Weiss, K. von Klitzing, K. Eberl, D. J. Bergman, and Y. Hornet; the exploitation of ultrasonic acoustic M. Strelniker, Anisotropic Magnetoresistance of a Classical antidot resonances by worker hornets and worker bees array, Phys. Rev. Lett. 77, 147{150 (1996). in the construction of highly symmetric combs in 4. D. J. Bergman and J. S. Ishay, Do Bees and Hornets Use Acoustic a hornets’ nest or beehive Resonance in Order to Monitor and Coordinate Comb Construction? Bulletin of Mathematical Biology 69(5), 1777, 1790 (2007). 5. D. J. Bergman and M. I. Stockman, Surface plasmon amplication by stimulated emission of radiation: Quantum generation of coherent surface plasmons in Nanosystems, Phys. Rev. Letters 90, 027402-1, 027402-4 (2003).
66 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Ady Arie
Affiliation: Electrical Engineering Email: [email protected] Web: http://www.eng.tau.ac.il/~ady/
Research Title Research Description Nonlinear optics, plasmonics, electron microscopy Our group is active in several areas of research: nonlinear optics, plasmonics and electron beam Selected Publications: shaping. 1. Voloch-Bloch N., Lereah Y., Lilach Y., Gover A. and Arie A. (2013). In nonlinear optics, we mainly concentrate on Generation of electron Airy beams, Nature 494, 331-335 . quadratic nonlinear processes in ferroelectric 2. Suchowski H., Porat G. and Arie A. (2014). Adiabatic processes in crystals. The ability to modulate the quadratic frequency conversion, Lasers and Photonics Reviews 8, 333-367 nonlinear coefficient is used for shaping the spatial 3. Epstein I. and Arie A. (2014). Arbitrary Bending Plasmonic Light and spectral response of the nonlinear crystal. Waves, Physical Review Letters 112, 023903. In plasmonics, our efforts in recent years have 4. Remez R. and Arie A. (2015). Super-narrow frequency conversion, focused on generating special types of plasmonic Optica 2, 472-475 . beams. To this end, we have developed special types 5. Shapira A., Naor L. and Arie A., (2015). Nonlinear optical holograms of couplers between free-space light beams and for spatial and spectral shaping of light waves, Science Bulletin 60, plasmonic beams, applying concepts and coding 1403-1415. schemes developed in the field of holography. In electron beam shaping, we utilize a recent technological breakthrough, enabling us to shape the phase and amplitude of electron beams by passing them through a thin SiN membrane, patterned by focused ion beam milling.
67 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Amir Boag
Affiliation: Electrical Engineering Email: [email protected] Web: https://www.eng.tau.ac.il/~boag/
Research Title Research Description Rectifying nano-antennas The dramatic increase in worldwide demand for electrical power makes it clear that the development Selected Publications: of clean, renewable alternative energy sources is 1. Z. Iluz and A. Boag, Dual-Vivaldi wide band nano-antenna with essential, with solar power harvesting as the leading high radiation efficiency over the infrared frequency band, Optics direction. The basic properties of conventional Letters, vol. 36, no 15, pp. 2773-2775, 2011. photovoltaic solar cells are determined by their 2. E. Strassburg, A. Boag, Y. Rosenwaks, Reconstruction of Electrostatic materials’ chemistry and the corresponding Force Microscopy Images, Review of Scientific Instruments, vol.76, electronic properties. As a result, such solar cells have 083705, 28 July 2005. inherent and fundamental limitations in terms of 3. Y. Yifat, Z. Iluz, D. Bar-Lev, M. Eitan, Y. Hanein, A. Boag, and J. Scheuer, optical bandwidth, efficiency and cost. On the other High load-sensitivity in wideband infrared dual-Vivaldi nanoantennas, hand, power harvesting utilizing RF approaches has Optics Letters, vol. 38, no. 2, pp. 205–207, 2013. demonstrated high efficiency (exceeding 85%) in 4. Y. Yifat, M. Eitan, Z. Iluz, Y. Hanein, A. Boag, and J. Scheuer, Highly the radio-frequency spectral range, as well as low efficient and broadband Wide-Angle Holography Using Patch- fabrication costs. The objective of our research is Dipole Nano-antenna Reflectarrays, Nano Letters, March 19, 2014. to develop new detection and power conversion 5. G. Y. Slepyan and A. Boag, Quantum non-reciprocity of nanoscale schemes for optical frequencies, based on metallic antenna arrays in timed Dicke states, Physical Review Letters, vol. rectifying nano-antennas (rectennas). A nano- 111, 023602, 11 July, 2013. rectenna includes two fundamental elements: an antenna and a rectifier. The antenna receives the EM wave and converts it into an alternating electric current (AC). The rectifier converts the AC current into a direct current (DC). We have demonstrated the ability to design, optimize and fabricate ultra-wideband nano-antenna arrays. We have measured the spectral properties of the scattered field from these antennas, and shown very good agreement with numerical simulations. We have also demonstrated preliminary success in integrating the nano-antennas with the rectifiers. We now intend to utilize these abilities to develop a new concept for solar-power harvesting, which can revolutionize the field by providing an inexpensive and efficient approach for direct EM to DC power conversion.
68 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Moshe Goldstein
Affiliation: Physics Email: [email protected] Web: http://www6.tau.ac.il/mgoldstein/
Research Title Research Description Theory of low-dimensional nanoscale electronic and photonic My research involves the theoretical (both analytical systems and numerical) study of low-dimensional/nanoscale electronic and photonic systems, in and out of Selected Publications: equilibrium. Nanoscale systems are immensely 1. J. I. Väyrynen, M. Goldstein, Y. Gefen, and L. I. Glazman, Resistance important as the basic building blocks of future of helical edges formed in a semiconductor heterostructure, Phys. electronic devices, which may lead, among other Rev. B. 90, 115309 (2014), Editors’ Suggestion. potential applications, to the eventual realization 2. M. Goldstein, M. H. Devoret, M. Houzet, and L. I. Glazman, Inelastic of scalable quantum computing. They can be microwave photon scattering off a quantum impurity in a Josephson- fabricated using a variety of materials, including junction array”, Phys. Rev. Lett. 110, 017002 (2013). semiconductor heterostructures, metallic nanowires 3. B. Bradlyn, M. Goldstein, and N. Read, “Kubo formulas for viscosity: and nanograins (normal or superconducting), Hall viscosity, Ward identities, and the relation with conductivity, carbon-based materials (graphene, nanotubes and Phys. Rev. B 86, 245309 (2012), Editors’ Suggestion. buckyballs), the recently discovered topological 4. M. Goldstein, R. Berkovits, and Y. Gefen, Population switching and insulators, and conducting polymers and single charge sensing in quantum dots: A case for a quantum phase molecules. Their behavior can also be simulated with transition, Phys. Rev. Lett. 104, 226805 (2010). ultracold atoms in optical traps. Not less importantly, 5. M. Goldstein and R. Berkovits, Duality between different geometries from a more fundamental perspective, nanoscale of a resonant level in a Luttinger liquid, Phys. Rev. Lett. 104, 106403 systems exhibit a variety of phenomena caused (2010). by strong electronic correlations, as well as their interplay with quantum interference effects and nonequilibrium behavior, all of which are central themes in current condensed matter research.
69 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Yoram Dagan
Affiliation: Physics Email: [email protected] Web: http://minerva.tau.ac.il/dagan/index.html
Research Title Research Description Emergent phenomena at surfaces and interfaces Recent developments in thin-film fabrication techniques have enabled the deposition of newly Selected Publications: designed and well controlled oxide interfaces. These 1. M. Ben Shalom, M. Sachs, D. Rakhmilevitch, A. Palevski and Y. Dagan, interfaces can have properties which are significantly Tuning spin-orbit coupling and superconductivity at the SrTiO3/ different from their constituent materials. Correlated LaAlO3 interface: a magneto-transport study, Phys. Rev. Lett. 104, electrons in oxide interfaces result in a variety of 126802 (2010). properties, such as metal-insulator transition, 2. A. Ron and Y. Dagan, One-dimensional quantum wire formed at superconductivity and magnetism, and these phase the boundary between two insulating LaAlO3/SrTiO3 interfaces, transitions can be tuned by external stimuli such as Phys. Rev. Lett. 112, 136801 (2014). electric and magnetic fields and pressure. The ability 3. E. Lahoud, E. Maniv, M. Shaviv, M. Naamneh, A. Ribak, S. Wiedmann, to tune the phase transitions makes these interfaces L. Petaccia, Z. Salman, K. B. Chashka, Y. Dagan, A. Kanigel, Evolution particularly interesting - both from the perspective of the Fermi surface of doped topological insulator with carrier of basic science, and as potential components for concentration, Phys. Rev. B 88, 195107 (2013). future electronic devices. Of particular interest 4. Itai Carmeli et al. and Yoram Dagan, Tuning the Critical Temperature are new interfaces that can be used in future of Cuprate Superconductor Films with Self‐Assembled Organic applications, such as spin-controlled electronics Layers, Angewandte Chemie International Edition, 51, 7162 (2012). (spintronics) and quantum computation. Other 5. E. Maniv, M. Ben Shalom, A. Ron, M. Goldstein, A. Palevski, and Y. fascinating examples are interfaces where multiple Dagan, Strong correlations elucidate the electronic structure and orders may coexist, such as: superconductivity phase-diagram of LaAlO3/SrTiO3 interface , Nature Communications coexisting with magnetism, which can result in 6, 8239 (2015). an exotic symmetry of the superconducting order- parameter, and ferromagnetism coexisting with ferroelectricity. Interface design has been proven successful in enhancing macroscopic orders, e.g. superconductivity, ferroelectricity and combining orders. Our challenge is to master these interfaces, understand them and use them as a platform for observation of exotic physical phenomena, as well as for new applications.
70 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Alexander Gerber
Affiliation: Physics Email: [email protected] Web: N/A
Research Title Research Description Hall effect spintronics Spintronics is an emerging field of basic and applied research in physics and engineering, in which the Selected Publications: electron’s magnetic degree of freedom - its spin 1. Milner A., Gerber A., Karpovsky M. and Gladkikh A. (1996). Spin - - may be exploited for classical and quantum Dependent Electronic Transport in Granular Ferromagnets. Phys. information processing. Carrying information in Rev. Lett. 76, 475 - 478. both the charge and spin of an electron potentially 2. Gerber A. (2007). Towards Hall Effect Spintronics. Jour. Magn. Magn. enables devices with greater functional diversity. Matt., 310, 2749. Our research focuses mainly on the spin-dependent 3. Segal A., Gerber A. and Karpovski M. (2011). Sixteen-states magnetic Hall effect in a variety of artificial nanoscale materials, memory based on the extraordinary Hall effect. J. Magn.Magn. and on its application in a new generation of Matt. 324, 1557. magnetic sensors, magnetic random access 4. Simons A., Gerber A., Korenblit I.Ya., Suslov A., Raquet B., Passacantando memories and logic devices. M., Ottaviano L., Impellizzeri G., Aronzon B. (2014). Components of strong magnetoresistance in Mn implanted Ge. J. Appl. Phys. 115, 093703 5. Winer G., Segal A., Karpovski M., Shelukhin V., and Gerber A. (2015). Probing Co/Pd interfacial alloying by the extraordinary Hall effect. J. Appl. Phys. 118, 173901.
71 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Dr. Guy Cohen
Affiliation: Chemistry Email: [email protected] Web: www.tau.ac.il/~gcohen/
Research Title Research Description Computational methods for nonequilibrium quantum many- Our group investigates nonequilibrium phenomena body systems in chemical and condensed matter physics. We try to understand how strongly correlated quantum Selected Publications: systems react to dissipative environments and to 1. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., 2015. Taming the external perturbations, particularly in the context dynamical sign problem in real-time evolution of quantum many- of the transport properties of nanosystems. This is a body problems. Phys. Rev. Lett. 115, 266802 . deeply challenging and fundamental problem, and 2. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., 2014. Green’s Functions we therefore work on state-of-the-art computational from Real-Time Bold-Line Monte Carlo Calculations: Spectral methods such as quantum Monte Carlo algorithms. Properties of the Nonequilibrium Anderson Impurity Model. Phys. We focus on methods for circumventing the Rev. Lett. 112, 146802. dynamical sign problem, a phenomenon which 3. Cohen, G., Gull, E., Reichman, D.R., Millis, A.J., Rabani, E., 2013. usually prevents Monte Carlo methods from Numerically exact long-time magnetization dynamics at the accessing nonequilibrium physics and dynamics. nonequilibrium Kondo crossover of the Anderson impurity model. Phys. Rev. B 87, 195108. 4. Cohen, G., Rabani, E., 2011. Memory effects in nonequilibrium quantum impurity models. Phys. Rev. B 84, 075150 5. Mocatta, D., Cohen, G., Schattner, J., Millo, O., Rabani, E., Banin, U., 2011. Heavily Doped Semiconductor Nanocrystal Quantum Dots. Science 332, 77 –81
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72 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Alexander Palevski
Affiliation: Physics Email: [email protected] Web: http://www.tau.ac.il/~apalev/
Research Title Research Description Quantum electronic transport in low dimensional systems Our research involves quantum electronic transport in condensed matter systems at low temperatures. Selected Publications: Topics are quite diverse, spanning many areas of 1. R. Hevroni, V. Shelukhin, M. Karpovski, M. Goldstein, E. Sela, Hadas modern solid state physics: superconductivity, Shtrikman and A. Palevski (2016). Suppression of Coulomb blockade ferromagnetism, the Quantum Hall effect and peaks by electronic correlations in InAs nanowires, Phys. Rev. B 93, mesoscopic physics. Due to the diversity of 035305. subjects, the materials investigated also cover a 2. E. Maniv, M. Ben Shalom, A. Ron, M. Mograbi, A. Palevski, M. Goldstein, broad range of solids: normal metals, ferromagnets, and Y. Dagan (2015). Strong correlations elucidate the electronic semiconductors, topological insulators and phase-diagram of LaAlO3/SrTiO3 interface, Nature Communications, superconductors. The common denominator of 6, 8239. the devices made of these material systems at our 3. Qi I. Yang, Merav Dolev, Li Zhang, Jinfeng Zhao, Alexander D. Fried, lab is low dimensionality - a vast majority of the Elizabeth Schemm, Min Liu, Alexander Palevski, Ann F. Marshall, experimentally studied electronic systems are either Subhash H. Risbud, and Aharon Kapitulnik (2013). Emerging weak two- or one-dimensional. The low dimensions of the localization effects on a topological insulator–insulating ferromagnet devices fabricated in the lab are achieved via state- (Bi2Se3-EuS) interface.Phys. Rev. B 88, 081407(R). of-the-art nanofabrication techniques, including 4. Nicholas P. Breznay, Hanno Volker, Alexander Palevski, Riccardo photolithography, electron beam lithography, Mazzarello, Aharon Kapitulnik, and Matthias Wuttig (2012). Weak focused ion beam microscopy and more. antilocalization and disorder-enhanced electron interactions in In recent years research at the lab has focused mainly annealed films of the phase-change compound GeSb2Te4. Phys. on the following topics: (1) Mesoscopic phenomena Rev. 73. and superconductivity in two-dimensional electron 5. I. Sternfeld, E. Levy, M. Eshkol, A. Tsukernik, M. Karpovski, Hadas gas formed at the interface between the two large
Shtrikman, A. Kretinin, and A. Palevski, (2011). Magnetoresistance gap insulators SrTiO3/LaAlO3 and in topological
Oscillations of Superconducting Al-Film Cylinders Covering InAs insulators BiSe3. Quantum interference effects were Nanowires below the Quantum Critical Point, Phys. Rev. Lett observed and analyzed, allowing us to establish the dephasing mechanism in these exotic systems. (2) The electronic correlations in InAs and GaAs semiconductor nanowires. The role of the electron- electron interaction was elucidated, and the so-called Luttinger liquid model was demonstrated as the adequate theory for transport in quantum nanowires. (3) Spin-orbit interaction and its effect on quantum transport in nanowires, and the role played in quantum interference phenomena in Aharonov Bohm rings. Currently we are studying the effect of the spin orbit interaction on Luttinger parameter on Berry phase in these systems.
73 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY RESEARCHERS
Prof. Ilan Goldfarb
Affiliation: Materials Science and Engineering Tel: 972-3-6407079 Email: [email protected] Web: http://www.eng.tau.ac.il/~ilang
Research Title Research Description Epitaxial nanostructures Self-assembled nanostructures are interesting from the structural-morphological standpoint, and also Selected Publications: due to their unusual physical properties. In my 1. I. Goldfarb, D. A. A. Ohlberg, J. P. Strachan, M. D. Pickett, J. J. Yang, laboratory we explore the self-assembled formation G. Medeiros-Ribeiro, R. S. Williams, Band offsets in transition-metal and mesoscopic ordering mechanisms of epitaxial oxide heterostructures, J. Phys. D - Appl. Phys. 46, 295303 (2013). nano-island arrays on surfaces, primarily with the aid 2. J.K. Tripathi, G. Markovich, I. Goldfarb, Self-Ordered Magnetic α-FeSi2 of a time-resolved scanning tunneling microscope Nano-Stripes on Si(111), Appl. Phys. Lett. 102, 251604 (2013). (STM), and the way these growth mechanisms affect 3. G. Cohen-Taguri, O. Sinkevich, M. Levinshtein, A. Ruzin, and I. Goldfarb, the resulting physical properties. For example, Atomic structure and electrical properties of In(Te) nano-contacts we have recently found that some metal-silicon on CdZnTe(110) by scanning probe microscopy, Adv. Funct. Mater. compounds which are non-magnetic in their bulk 20(2) 215-223 (2010). form, can exhibit interesting magnetic properties 4. I. Goldfarb, Step-mediated size-selection and ordering of when grown as self-ordered nano-islands, and that heteroepitaxial nanocrystals, Nanotechnology 18, 335304 (2007). these properties can be further tuned by controlling 5. I. Goldfarb, Effect of strain on the appearance of subcritical nuclei the size and geometry of the nano-island arrays. of Ge nanohuts on Si(001), Phys. Rev. Lett. 95, 025501-4 (2005).
74 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY PUBLICATIONS
Publications
1. Nurit Atar, Eitan Grossman, Irina Structural Transition in ACS Photonics,5b00091,DOI: Gouzman, Asaf Bolker, Vanessa Phospholipid-Inspired 10.1021/acsphotonics, (2015). J. Murray, Brooks C. Marshall, Aromatic Phosphopeptide 13. Michal Eitan, Zeev Iluz, Yuval Min Qian, Timothy K. Minton, Nanostructures, ACS Yifat, Amir Boag, Yael Hanein, Yael Hanein, Atomic Oxygen Nano,9,4085–4095, (2015). and Jacob Scheuer,Degeneracy Durable and Electrically- 7. Ramishetti S.*, Kedmi R.*, Breaking of Wood’s Anomaly Conductive CNT POSS Polyimide Goldsmith M., Leonard F., for Enhanced Refractive Index Flexible Films for Space Speague AG., Godin B., Gozin Sensing, ACS Photonics,2 (5) Applications, ACS Appl. Mater. M., Cullis P., Dykxhoorn DM., and ,615–621, (2015). Interfaces,5b02200,DOI:10.1021/ Peer D ,Systemic gene silencing 14. A. Handelman,B. Apter, acsami., (2015). in primary T lymphocytes using N.Turko,Gil Rosenman,Linear 2. Nurit Atar, Eitan Grossman, targeted lipid nanoparticles., and Nonlinear Optical Irina Gouzman, Asaf Bolker, ACS Nano,9(7),6706-6716, Waveguiding Effects in Bio- and Yael Hanein, Reinforced (2015). inspired Diphenylalanine Carbon Nanotubes as 8. Cohen ZR*, Ramishetti S*, Peptide Nanotubes, Acta Electrically Conducting and Peshes-Yaloz N*, Goldsmith Biomateriala,4,1-8, (2015). Flexible Films for Space M, Wohl A, Zibly Z, and Peer D 15. G.I. Livshits, J. Ghabboun, N. Applications, ACS Appl. Mater. ,Localized RNAi therapeutics of Borovok, A.B. Kotlyar, D. Porath Interfaces,505811g,DOI: chemo-resistant grade IV glioma ,Comparative Electrostatic 10.1021/am, (2014). using hyaluronan-grafted Force Microscopy of Tetra‐and 3. Ariel J. Ben-Sasson, Daniel lipid-based nanoparticles., ACS Intra‐molecular G4‐DNA , Adv. Azulai, Hagit Gilon, Antonio Nano,9(2),1581-1591, (2015). Materials,26,4981-4985, (2014). Facchetti, Gil Markovich, Nir 9. O. Hazut, B.C. Huang, A. Pantzer, 16. Dvashi Z, Shalom HJ, Shoat M, Tessler,Self-Assembled Metallic I. Amit, Y. Rosenwaks, A. Kohn, Ben-Meir D, Ferber S, Satchi- Nanowire-Based Vertical C.-S. Chang, Y.-P. Chiu, and Fainaro R, Ashery-Padan R, Organic Field-Effect Transistor, R. Yerushalmi,Parallel p-n Rosner M, Solomon AS and ACS Applied Materials and Junctions across Nanowires by Lavi S,Protein Phosphatase Interfaces,7,2149–2152, (2015). One-Step Ex Situ Doping, ACS Magnesium Dependent 4. Ayala Lampel, Yaron Bram, Anat nano,8,8357–8362, (2014). 1A governs the wound Ezer, Ronit Shaltiel-Kario, Jamil 10. Ramishetti, Srinivas; Kedmi, healing-inflammation- S. Saad, Eran Bacharach, Ehud Ranit; Goldsmith, Meir; Leonard, angiogenesis cross talk on Gazit,Targeting the Early Step Fransisca; Sprague, Andrew G.; injury, American Journal of of Building Block Organization Godin, Biana; Gozin, Michael; Pathology,184,2396-2950, in Viral Capsid Assembly, ACS Cullis, Pieter R.; Dykxhoorn, (2014). Chemical Biology,10,1785–1790, Derek M.; Peer, Dan ,Systemic 17. Tatyana Polenova, Rupal (2015). gene silencing in primary T Gupta, Amir Goldbourt,Magic 5. Michal Pellach, Yoav Atsmon- lymphocytes using targeted Angle Spinning NMR Raz, Eyal Simonovsky, Hugo lipid nanoparticles., ACS Spectroscopy: A Versatile Gottlieb, Guy Jacoby, Roy Beck, Nano,9(7),6706-6716, (2015). Technique for Structural and Lihi Adler-Abramovich, Yifat 11. M. Eitan, Z. Iluz, Y. Yifat*, Dynamic Analysis of Solid- Miller, Ehud Gazit,Spontaneous A. Boag, Y. Hanein, and J. Phase Systems, Analytical Structural Transition in Scheuer,Degeneracy Breaking of Chemistry,87,5458-5469, (2015). Phospholipid-Inspired Wood’s Anomaly for Enhanced 18. Yaron Bram, Ayala Lampel, Aromatic Phosphopeptide Refractive Index Sensing, ACS Ronit Shaltiel-Karyo, Anat Ezer, Nanostructures, ACS Photonics,2,615−621 , (2015). Roni Scherzer-Attali, Daniel nano,9,4085-4095, (2015). 12. Michal Eitan , Zeev Iluz , Segal, Ehud Gazit,Monitoring 6. Michal Pellach, Yoav Atsmon- Yuval Yifat , Amir Boag , and Targeting the Initial Raz, Eyal Simonovsky, Hugo Yael Hanein , and Jacob Dimerization Stage of Amyloid Gottlieb, Guy Jacoby, Roy Beck, Scheuer,Degeneracy breaking of Self-Assembly, Angewandte Lihi Adler-Abramovich, Yifat Wood›s anomaly for enhanced Chemie International Miller, Ehud Gazit,Spontaneous refractive index sensing, Edition,54,2062–2067, (2015).
77 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY PUBLICATIONS
19. Cyrus R Safinya, Joanna Deek, 26. Shahar Shefer, Carlos Gordon, characterization of viral mutant Roy Beck, Jayna B Jones, Youli Karen B. Avraham, Matti Mintz, spectrum., Bioinformatics , Jul Li, Assembly of Biological Balance deficit enhances anxiety 1;31(13),2141-50., (2015). Nanostructures: Isotropic and and balance training decreases 33. Michal Shevach, Rotem Zax, Liquid Crystalline Phases of anxiety in vestibular mutant Alona Abrahamov, Sharon Neurofilament Hydrogels, mice, Behav. Brain Res.,276,76- Fleischer, Assaf Shapira and Annu. Rev. Condens. Matter 83, (2015). Tal Dvir,Omentum ECM-based Phys.,6,113-136, (2015). 27. Gal Herzog, Merav D. Shmueli, hydrogel as a platform for 20. Alex Henning, Benjamin Limor Levy, Liat Engel, Ehud cardiac cell delivery, Biomedical Klein, Kris A. Bertness, Paul T. Gazit, Frank-Gerrit Klärner, Materials,10,34106, (2015). Blanchard, Norman A. Sanford, Thomas Schrader, Gal Bitan, 34. Kisin-Finfer E, Ferber S, Blau Yossi Rosenwaks,Measurement Daniel Segal,The Lys-Specific R, Satchi-Fainaro R, Shabat of the electrostatic edge effect Molecular Tweezer, CLR01, D,Synthesis and evaluation in wurtzite GaN nanowires, Modulates Aggregation of of new NIR-fluorescent Appl. Phys. Lett.,105,213107-9, the Mutant p53 DNA Binding probes for cathepsin B: ICT (2014). Domain and Inhibits Its Toxicity, versus FRET as a turn-ON 21. D. Permyakov, I. Sinev, D. Biochemistry,54,3729–3738, mode-of-action, Bioorganic Markovich, P. Ginzburg, A. (2015). and Medicinal Chemistry Samusev, P. A. Belov, V. Valuckas, 28. Bonzi G, Salmaso S, Scomparin Letters,24(11),2453-2458, (2014). A. Kuznetsov, B. Luk’yanchuk, A. A, Eldar-Boock A, Satchi-Fainaro 35. Yaron Tomer Cordova Yossi, Miroshnichenko, D. Neshev, and R, Caliceti P,A novel pullulan Juxtacrine signaling is Y.S. Kivshar, Probing magnetic bioconjugate for selective inherently noisy, Biophysical and electric optical responses of breast cancer bone metastases Journal,107,2417-24, (2014). silicon nanoparticles, Appl. Phys. treatment, Bioconjugate 36. Scomparin A, Polyak D, Lett. ,106,171110, (2015). Chemistry,26(3),489-501, (2015). Krivitsky A, Satchi-Fainaro 22. G.Winer, A.Segal, 29. E.Y. Levanon and E. R,Achieving successful M.Karpovski, V.Shelukhin Eisenberg,Does RNA editing delivery of oligonucleotides and A.Gerber,Probing Co/ compensate for Alu invasion - From physico-chemical Pd interfacial alloying by the of the primate genome?, characterization to in vivo extraordinary Hall effect, Appl. BioEssays,37,175-181, (2015). evaluation, Biotechnology Phys.Lett.,N/A,N/A, (2015). 30. Hadas Zur, Tamir Advances,33(6),1294–1309, 23. Freeman, A., Dror, Y., Porat, C. Tuller,Exploiting hidden (2015). O., Hadar, N., & Diamand, Y. S. information interleaved in the 37. Alexandra Dana, Tamir ,Silver-Coated Biologically Active redundancy of the genetic Tuller,Properties and Protein Hybrids: Antimicrobial code without prior knowledge., determinants of codon Applications, Applied Mechanics Bioinformatics,31,1161-8, (2015). decoding time distributions., and Materials ,749,4, (2015). 31. S. Alon, M. Erew and E. BMC Genomics.,Suppl 6,S13, 24. Ilan Goldfarb, Stanley Eisenberg,DREAM: a webserver (2014). Williams,Conduction centers for the identification of editing 38. Landesman-Milo D. Ramishetti in a Ta2O5-delta Fermi glass, sites in mature miRNAs S. and Peer D. ,Nanomedicine Applied Physics A,114,287-289, using deep sequencing data, as an emerging platform (2014). Bioinformatics,31,2568-2570, for metastatic lung cancer 25. S. Krylov, S. Lulinsky, B. R. Ilic, I. (2015). therapy, Cancer and Metastasis Schneider,Collective Dynamics 32. Ofer Isakov, Antonio V. Bordería, Reviews,34(2),291-301, (2015). and Pattern Switching in an David Golan, Amir Hamenahem, 39. Hazan-Halevy I.*, Rosenblum Array of Parametrically Excited Gershon Celniker, Liron Yoffe, D.*,Weinstein S.,Bairey O., Micro Cantilevers Interacting Hervé Blanc, Marco Vignuzzi Raanani P. and Peer D ,Cell- Through Fringing Electrostatic and Noam Shomron,Deep specific uptake of mantle cell Fields, Applied Physics sequencing analysis of viral lymphoma-derived exosomes Letters,105,71909, (2014). infection and evolution by malignant and non- allows rapid and detailed malignant B-lymphocytes.,
78 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY PUBLICATIONS
Cancer Letters,364(1),59-69, cell permeability and antiviral monitoring of drug release, (2015). activity of HIV-1 major ChemMedChem,10,999-1007, 40. Ferber S, Baabur-Cohen H, Blau homology region fragments, (2015). R, Epshtein Y and Satchi-Fainaro Chemical Communicationsα- 52. Lior Medina, Rivka Gilat, Slava R,Polymeric nanotheranostics Aminoisobutyric acid Krylov,Bouncing and dynamic for real-time non-invasive incorporation induces trapping of a bistable curved optical imaging of breast cancer cell permeability and micro beam actuated by a progression and drug release, antiviral activity of HIV-1 suddenly applied electrostatic Cancer Letters,352(1),81-89, major homology region force, Communications (2014). fragments,51,12349-12352, in Nonlinear Science and 41. Ron Amon, Eliran Moshe (2015). Numerical Simulation,NA,NA, Reuven, Shani Leviatan Ben- 47. Kai Tao, Aviad Levin, Ehud (2015). Arye and Vered Padler-Karavani Gazit,Fmoc Modified Short 53. Galit Fichman, Tom Guterman, ,Glycans in immune recognition Peptides: Simple Biomolecules Lihi Adler-Abramovicha, Ehud and response, Carbohydrate to Meet Functional Gazit,Synergetic functional Res,389,115-122, (2014). Materials, Chemical Society properties of two-component 42. Nurit Paz-Yaacov, Lily Bazak, Reviews,NA,NA, (2015). single amino acid-based Ilana Buchumenski, Hagit T. 48. Buzhor, Marina; Harnoy, Assaf hydrogels, CrystEngComm,-,-, Porath, Miri Danan-Gotthold, J.; Tirosh, Einat; Barak, Ayana; (2015). Binyamin A. Knisbacher, Eli Schwartz, Tal; Amir, Roey 54. Galit Fichman, Tom Guterman, Eisenberg, Erez Y. Levanon J.,Supramolecular translation Lihi Adler-Abramovich, ,Elevated RNA Editing Activity of enzymatically triggered Ehud Gazit,Synergetic Is a Major Contributor to disassembly of micelles into functional properties of Transcriptomic Diversity in tunable fluorescent responses, two-component single Tumors, Cell Reports,13,xxx, Chemistry - A European amino acid-based hydrogels, (2015). Journal,0,DOI: 10.1002/ CrystEngComm,na,na, (2015). 43. Gil Nifker, Michal Levy‐Sakin, chem.201502988, (2015). 55. Adi Laser-Azogui, Micha Yifat Berkov‐Zrihen, Tamar 49. Marina Buzhor, Assaf J. Kornreich, Eti Malka-Gibor, Roy Shahal, Tslil Gabrieli, Micha Harnoy, Einat Tirosh, Ayana Beck,Neurofilament assembly Fridman, Yuval Ebenstein,One‐ Barak, Tal Schwartz, Roey J. and function during neuronal Pot Chemoenzymatic Amir,Supramolecular Translation development, Current opinion Cascade for Labeling of of Enzymatically Triggered in cell biology,32,92-101, (215). the Epigenetic Marker 5‐ Disassembly of Micelles into 56. Alexander Aizikovich, Avital Hydroxymethylcytosine, Tunable Fluorescent Responses, Shlomovich, Adva Cohen, ChemBioChem,16,1857-1860, Chemistry - A European Michael Gozin,The nitration (2015). Journal,NA,NA, (2015). pattern of energetic 3,6- 44. Kerem Goren, Jeny Karabline- 50. Hadar Ivanir-Dabora, Evgeny diamino-1,2,4,5-tetrazine Kuks, Yael Shiloni, Einav Barak- Nimerovsky, PK Madhu, Amir derivatives containing azole Kulbak, Scott J. Miller, Moshe Goldbourt ,Site-Resolved functional groups., Dalton Tra Portnoy,Multivalency as a Key Backbone and Side-Chain nsactions,44(31),13939-13946, Factor for High Activity of Intermediate Dynamics in a (2015). Selective Carbohydrate-Binding Module 57. Jones, C., Qian, D., Kim, S.M., Li, 45. Supported Organocatalysts for Protein Studied by Magic-Angle S., Ren, D., Knapp, L., Sprinzak, the Baylis–Hillman Reaction, Spinning NMR Spectroscopy, D., Avraham, K.B., Matsuzaki, F., Chemestry a European Chemistry A European Chi, F. and Chen, P. ,Ankrd6 is a Journal,21,1191-1197, (2015). Journal,21,10778-10785, (2015). mammalian functional homolog 46. Ayala Lampel, Efrat Elis, Tom 51. Orit Redy-Keisar, Sharon Ferber, of Drosophila planar cell polarity Guterman, Sharon Shapira, Ronit Satchi-Fainaro, Doron gene diego and regulates Pini Marco, Eran Bacharach, Shabat ,NIR fluorogenic dye as coordinated cellular orientation Ehud Gazit,α-Aminoisobutyric a modular platform for prodrug in the mouse inner ear, Dev. acid incorporation induces assembly: Real-time in vivo Biol.,395,62-72, (2014).
79 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY PUBLICATIONS
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C. Cuevas, L. Gurevich, A. B. Weinhold, Tobias Ambjörnsson, 168. Ana Libster-Hershko, Sivan Kotlyar, D. Porath,Long-range Fredrik Westerlund, Yuval Trajtenberg-Mills and Ady charge transport in single Ebenstein,Bacteriophage Arie,Dynamic Control of G4-DNA molecules , Nature strain typing by rapid single Light Beams in Second Nanotechnology ,9,1040-1046, molecule analysis, Nucleic Acids Harmonic Generation, Optics (2014). Research,1,1, (2015). Letters,40,1944-1947, (2015). 153. Redy-Keisar O, Kisin-Finfer E, 160. Roei Remez and Ady Arie,Super- 169. Michael Zuzovski, Amir Boag, Shiran Ferber, Satchi-Fainaro narrow frequency conversion, Amir Natan,Auxilliary grid R*, and Shabat D*,Synthesis Optica,2,472-475, (2015). method for the calculation of and Use of QCy7-derived 161. Omer Tzang, Doron Azoury,Ori electrostatic terms in Density Modular Probes for Detection Cheshnovsky,Super resolution Functional Theory on a real- and Imaging of Biologically methodology based on space grid, PCCP,C5CP01090J,8, Relevant Analytes, Nature temperature dependent (2015). Protocols,9(1),27-36, (2014). Raman scattering., Optics 170. Amir Natan,Fock-exchange 154. Miri Danan-Gotthold, Regina Express,23,17929-40, (2015). for periodic structures in the Golan-Gerstl, Eli Eisenberg, 162. Omer Tzang, Ori real-space formalism and the Keren Meir, Rotem Karni, Erez Cheshnovsky,New KLI approximation, PCCP,DOI: Y. Levanon,Identification of modes in label-free super 10.1039/c5cp01093d,6, (2015). recurrent regulated alternative resolution based on photo- 171. Oz Oshri, Fabian Brau, Haim splicing events across human modulated reflectivity, Optics Diamant,Wrinkles and folds in a solid tumors, Nucleic acid Express,23,20926-20932, (2015). fluid-supported sheet of finite research,43,5130-5144, (2015). 163. Mor Habaza, Barak Gilboa, size, Phys Rev E,91,52408, (2015). 155. Redy-Keisar O, Kisin-Finfer E, Yael Roichman, and Natan T. 172. A. S. Shalin, S. V. Sukhov, A. A. Shiran Ferber, Satchi-Fainaro Shaked,Tomographic phase Bogdanov, P. A. Belov, and P. R*, and Shabat D*,Synthesis microscopy with 180° rotation Ginzburg, Optical pulling forces and Use of QCy7-derived of live cells in suspension by in hyperbolic metamaterials, Modular Probes for Detection holographic optical tweezers. Phys. Rev. A ,91,63830, (2015). and Imaging of Biologically , Optics Letters,40,1881-1884, 173. S. Lerer, N. Bachar, G. Deutscher, Relevant Analytes, Nature (2015). and Y. Dagan,Nernst effect Protocols,9(1),27-36, (2014). 164. O. Kotlicki, J. Scheuer,Wideband beyond the coherence critical 156. Miri Danan-Gotthold, Regina Perfect Coherent Absorber field of a nanoscale granular Golan-Gerstl, Eli Eisenberg, based on White Light Cavity, superconductor, Phys. Rev. Keren Meir, Rotem Karni, Erez Optics Letters,39,6624–6627 , B,90,214521, (2014). Y. Levanon,Identification of (2014). 174. A. P. Slobozhanyuk, P. Ginzburg, recurrent regulated alternative 165. Brenda Dana, Boris A. Malomed D. A. Powell, I. Iorsh, A. S. Shalin, splicing events across human and Alon Bahabad,Breathing P. Segovia, A. V. Krasavin, G. A. solid tumors, Nucleic acid solitary-pulse pairs in a linearly Wurtz, V.A. Podolskiy, P. A. Belov research,43,5130-5144, (2015). coupled system, Optics and A. V. Zayats,Purcell effect 157. Tamir Tuller, Hadas Zur ,Multiple Letters,39,4, (2014). in Hyperbolic Metamaterial roles of the coding sequence 166. Ksawery Kalinowski, Asia Resonators, Phys. Rev. B,-,-, 5› end in gene expression Shapira, Ana Libster-Hershko, (2015). regulation, Nucleic Acids and Ady Arie,Nonlinear 175. S. Yogev, and Y. Rosenwaks,Low Res.,43,13-28, (2015). diffraction from high-order density of gap states and 158. D Torchinsky, Y Ebenstein,Sizing Hermite–Gauss beams, Optics unpinned Fermi level in femtogram amounts of dsDNA letters,40,13-16, (2015). n-channel organic thin-film by single-molecule counting, 167. Yuval Tsur, Itai Epstein and Ady transistors, Phys. Rev. B, rapid Nucleic Acids Research,1,1, Arie,Arbitrary Holographic comm.,89,081409-081415, (2015). Spectral Shaping of Plasmonic (2014). 159. Assaf Grunwald, Moran Broadband Excitations, Optics 176. A. Ron, E. Maniv, D. Graf, J.-H. Dahan, Anna Giesbertz, Adam Letters,40,1615-1618, (2015). Park, and Y. Dagan,Anomalous Nilsson, Lena K Nyberg, Elmar Magnetic Ground State in
85 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY PUBLICATIONS
an LaAlO3/SrTiO3 Interface Physical Review A,91,053841-1 - Urbakh,Critical Length Limiting Probed by Transport through 053841-9, (2015). Superlow Friction, Physical Nanowires, Phys. Rev. 184. David J. Bergman,Perfect Review Letters ,114,55501, Lett,113,216801, (2014). imaging of a point charge in (2015). 177. I. V. Iorsh, A. N. Poddubny, P. the quasistatic regime, Physical 192. R. Hevroni, V. Shelukhin, M. Ginzburg, P.A. Belov, and Y. S. Review A,89,015801 (4 pp.), Karpovski, M. Goldstein, E. Kivshar,Compton like polariton (2014). Sela, Hadas Shtrikman and scattering in hyperbolic 185. Yakov M. Strelniker and D. A. Palevski,Suppression of metamaterials, Phys. Rev. J. Bergman,Strong angular Coulomb blockade peaks by Lett.,114,185501, (2015). magneto-induced anisotropy of electronic correlations in InAs 178. D. Bar-Lev, J. Scheuer, Plasmonic Voigt effect in metal-dielectric nanowires, Physical Review Meta-Surface for Efficient Ultra- metamaterials with periodic Letters ,NA,NA, (2015). Short Pulse Laser-Driven Particle nanostructures, Physical Review 193. Ming Ma, Igor M. Sokolov, Wen Acceleration, Phys. Rev. ST Accel. A,89,125312 (12 pp.), (2014). Wang, Alexander E. Filippov, Beams,17,121302, (2014). 186. Asaf Farhi and David J. Quanshui Zheng, Michael 179. Eliezer Halpern, Gilad Cohen, Bergman,Analysis of a Veselago Urbakh,Diffusion through Shahar Gross, Alexander lens in the quasistatic regime, Bifurcations in Oscillating Henning, Max Matok, Andrey Physical Review A,90,013806 (10 Nano- and Microscale Contacts: V. Kretinin, Hadas Shtrikman, pp.), (2014). Fundamentals and Applications, and Yossi Rosenwaks,Measuring 187. Amir Hevroni, Boris Tsukerman, PHYSICAL REVIEW X ,5,31020, surface state density and energy Gil Markovich,Probing (2015). distribution in InAs nanowires, magnetization dynamics 194. S. Mahajne, D. Guetta, S. Phys. Status Solidi,211,473–482, in individual magnetite Lulinsky, S. Krylov, and Y. (2014). nanocrystals using Linzon, ,Liquid mass sensing 180. D. Bartov, A. Segal, M. Karpovski, magnetoresistive scanning using resonating microplates and A. Gerber,Absence of the tunneling microscopy, Physical under harsh drop and spray ordinary and extraordinary review B, (2015). conditions, Physics Research Hall effects scaling in granular 188. Eial Teomy and Yair Shokef,The International,2014,320324, ferromagnets at metal-insulator relation between the structure (2014). transition, Phys.Rev.B,90,144423, of blocked clusters and 195. Naum Parkansky, Violetta (2014). the relaxation dynamics in Yakubov, Evelina Faktorovich 181. Michael Zuzovski, Amir Boag, kinetically-constrained models, Simon, Boris A. Alterkop, and Amir Natan,An Auxiliary Physical Review E,NA,NA, (2015). Raymond L. Boxman, Olga Grid Method for the Calculation 189. Roy Shiloh, Yuval Tsur, Roei Berkh,Removal of Methylene of Electrostatic Terms in Density Remez, Yossi Lereah, Boris A. Blue from Aging Water Solutions Functional Theory on a Real- Malomed, Vladlen Shvedov, Cyril Treated by a Submerged Arc, Space Grid, Physical Chemistry Hnatovsky, Wieslaw Krolikowski, Plasma Chemistry and Plasma Chemical Physics,10.1039/ and Ady Arie,Unveiling the Prpocessing,34,745-754, (2014). C5CP01090J,10.1039/ Orbital Angular Momentum 196. Alon Diament, Tamir C5CP01090J, (2015). and Acceleration of Electron Tuller,Improving 3D Genome 182. Brenda Dana, Alon Bahabad and Beams, PHYSICAL REVIEW Reconstructions Using Boris A. Malomed, CP symmetry LETTERS,114,096102-1 - 096102- Orthologous and Functional in optical systems, Physical 5, (2015). Constraints., PLoS Comput Review A,91,11, (2015). 190. Shenhe Fu, Yuval Tsur, Jianying Biol.,11,e1004298., (2015). 183. Liran Naor, Shani Sharabi, Irit Zhou, Lev Shemer and Ady 197. Gilad Wallach, Jules Lallouette, Juwiler and Ady Arie,Nonlinear Arie,Propagation dynamics of Nitzan Herzog, Maurizio De Pitta, scattering in photonic crystals Airy water wave pulses, Physical Eshel Ben Jacob, Hugues Berry, having dislocations with Review Letters,115,034501-1 - and Yael Hanein ,Glutamate fractional topological character 034501-5, (2015). Mediated Astrocytic Filtering and multiple dislocations, 191. Ming Ma, Andrea Benassi, of Neuronal Activity, PLOS Andrea Vanossi, Michael
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Computational Biology,journal. calculation of the local electric Tuller.,Rationally designed, pcbi.1003964,10.1371, (2014). field of an oscillating dipole, heterologous S. cerevisiae 198. Yifat Goldschmidt, Evgeny Proc. SPIE Meeting on Optics transcripts expose novel Yurkovsky, Amit Reif, Roni and Photonics,9547,95471R (7 expression determinants., RNA Rosner, Amit Akiva, Iftach pp.), (2015). Biol.,12,972-84., (2015). Nachman ,Control of relative 204. D. J. Bergman and A. 210. Gagandeep Kaur, Lihi Adler- timing and stoichiometry Farhi,Perfect Optical Imaging Abramovich, Ehud Gazit, by a master regulator, PLoS of a Veselago Lens: Eigenstate Sandeep Verma,Ultrastructure ONE,10(5),e0127339, (2015). Based Analysis, Proc. SPIE of metallopeptide-based soft 199. Merav D. Shmueli, Lee Meeting on Optics and spherical morphologies, RSC Schnaider, Gal Herzog, Photonics,9547,954706 (11 pp.), Advances,4,64457-64465, (2014). Ehud Gazit, Daniel (2015). 211. Kai Tao, Eyal Yoskovitz, Lihi Segal,Computational and 205. Yakov M. Strelniker and D. J. Adler-Abramovicha, Ehud Experimental Characterization Bergman,Magneto-Optical Gazit,Optical property of dVHL Establish a Drosophila Response of a Periodic modulation of Fmoc group by Model of VHL Syndrome, PLOS Metallic Nano-Structure, Proc. pH-dependent self-assembly, ONE,9,e109864, (2014). SPIE Meeting on Optics and RSC Advances,5,73914-73918, 200. Vertkin, I., Styr, B., Slomowitz, Photonics,9547,954705 (12 pp.), (2015). E., Ofir, N., Shapira, I., Berner, (2015). 212. Kai Tao, Eyal Yoskovitz, Lihi D., Fedorova, T., Laviv, T., Barak- 206. Parry Chen, Jacob Ben-Yakar, Adler-Abramovich, Ehud Broner, N., Greitzer-Antes, Yonatan Sivan, and David J. Gazit,Optical property D., Gassmann, M., Bettler, B., Bergman,Reinterpreting the modulation of Fmoc group by Lotan, I., Slutsky, I. ,GABAB magnetoelectric coupling pHdependent self-assembly, receptor deficiency causes of infinite cylinders using RSC Advances,5,73914, (2015). failure of neuronal homeostasis symmetry: a simple TM 213. Gilad Poker, Michael Margaliot, in hippocampal networks. , and TE view, Proc. SPIE Tamir Tuller,Sensitivity of mRNA PNAS,112(25),E3291-9, (2015). Meeting on Optics and Translation., Sci Rep.,5,12795, 201. Yakov M. Strelniker, David Photonics,9547,95471S (9 pp.), (2015). J. Bergman, and Anna O. (2015). 214. Sidelman, N.; Cohen, M.; Kolbe, Voznesenskaya,,Strong angular 207. Omry Morag, Nikolaos G. A.; Zalevsky, Z.; Herrmann, anisotropy of Voigt effect Sgourakis, David Baker, A.; Richter, S. ,Rapid Particle and other magneto-optical Amir Goldbourt,The NMR– Patterning in Surface phenomena in ordered metal- Rosetta capsid model of Deposited Micro-Droplets of dielectric metamaterials, Proc M13 bacteriophage reveals Low Ionic Content via Low- Int Conf Days on Diffraction, a quadrupled hydrophobic Voltage Electrochemistry and Berlin, 2014,Proceedings of the packing epitope, Proceedings Electrokinetics, Sci. Rep,5,13095, International Conference,1-6, of the National Academy of (2015). (2014). Sciences of the USA,112,971- 215. Shira Shaham-Niv, Lihi Adler- 202. Shahar Nisemblat, Oren Yaniv, 976, (2015). Abramovich, Lee Schnaider, Avital Parnas, Felix Frolow, 208. Zohar Zafrir, Tamir Ehud Gazit,Extension of the Abdussalam Azem,Crystal Tuller,Nucleotide sequence generic amyloid hypothesis to structure of the human composition adjacent to nonproteinaceous metabolite mitochondrial chaperonin intronic splice sites improves assemblies, Science Advances,1, symmetrical football complex., splicing efficiency via its effect e1500137, (2015). Proc Natl Acad Sci U S on pre-mRNA local folding in 216. Guy Jacoby, Keren Cohen, Kobi A,112,6044-6049, (2015). fungi., RNA,21,1704-18., (2015). Barkan, Yeshayahu Talmon, Dan 203. A. Farhi and D. J. Bergman,Non- 209. Tuval Ben-Yehezkel, Shimshi Peer, Roy Beck,Metastability in quasi-static eigenstates of Atar, Hadas Zur, Alon Diament, lipid based particles exhibits Maxwell›s equations in a two- Eli Goz, Tzipy Marx, Rafael temporally deterministic and constituent composite medium Cohen, Alexandra Dana, Anna controllable behavior, Scientific and their application to a Feldman, Ehud Shapiro, Tamir reports,5,NA, (2015).
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217. Jacoby G.*, Cohen K.*, Tamon electrostatically actuated initially Samuel A. Safran,Response of I., Peer D *. and Back-Barkai curved pre-stressed micro adherent cells to mechanical R*,Metastability in lipid beams, Sensors and Actuators A: perturbations of the based particles exhibits Physical,220,323 – 332, (2014). surrounding matrix, Soft temporally deterministic and 225. Carmit Porat-Ophir, Vladimir Matter,11,1412, (2015). controllable behavior. , Scientific Dergachev, Anton Belkin, Sefi 231. Evgeny Nimerovsky, Anat Reports,9481,5, (2015). Vernicka, Genrietta Freynd, Haimovich, Amir Goldbourt,An 218. Kai Tao, Lihi Adler-Abramovich, Mikhail Katsnelson, Viktor optimal double-magic flip Ehud Gazit,Controllable Chetvertnykh, Judith Rishpon, angle for performing the Phase Separation by Boc- Yosi Shacham-Diamand,Chip distance measurement REDOR Modified Lipophilic Acid as level agitation effects on the experiment on a spin S=1, a Multifunctional Extractant, electrochemical sensing of Solid State Nuclear Magnetic Scientific Reports,NA,NA, (2015). alkaline-phosphatase expressed Resonance,NA,NA, (2015). 219. Alex Dymshits, Alex Henning, from integrated liver tissue, 232. Ingeborg M Storm, Micha Gideon Segev, Yossi Rosenwaks Sensors and Actuators B: Kornreich, Armando Hernandez- & Lioz Etgar,The electronic Chemical,213,9, (2015). Garcia, Ilja K Voets, Roy Beck, structure of metal oxide/ 226. Ragones, H., Schreiber, D., Martien A Cohen Stuart, Frans organo metal halide perovskite Inberg, A., Berkh, O., Kósa, AM Leermakers, Renko De junctions in perovskite G., Freeman, A., & Shacham- Vries,Liquid Crystals of Self- based solar cells, Scientific Diamand, Y. ,Disposable Assembled DNA Bottlebrushes, Reports,5,8704, (2015). electrochemical sensor The Journal of Physical 220. O. Y. Fajardo, F. Bresme, prepared using 3D printing Chemistry B,119,4084-4092, A. A. Kornyshev, M. for cell and tissue diagnostics, (2015). Urbakh,Electrotunable Lubricity Sensors and Actuators B: 233. Oman Walther, Itai Carmeli, with Ionic Liquid Nanoscale Chemical,216,9, (2015). Reinhard Schneider, Dagmar Films, Scientific Reports,5,7698, 227. A. Henning, M. Molotskii, Gerthsen, Kurt Busch, Christian (2015). N. Swaminathan, Y. Vaknin, Matyssek, Ayala Shvarzman, 221. A. A. Bogdanov, A. S. Shalin, A. Godkin, G. Shalev, and Y. Tsofar Maniv, Shachar Richter, and P. Ginzburg,Optical forces Rosenwaks,Electrostatic Limit of Hagai Cohen,Interslit coupling in nanorod metamaterial, Detection of Nanowire-based via ultrafast dynamics across accepted for Scientific Reports., Sensors, Small,10,201500566, gold-film hole arrays, The Scientific Reports,-,-, (2015). (2015). Journal of Physical Chemistry 222. A. S. Baimuratov, I. D. Rukhlenko, 228. S. Semin,A. van Etteger,N. C,118,11043-11049, (2014). R. E. Noskov, P. Ginzburg, Y. K. Amdursky,L. Kulyuk,S. Gun›ko, A. V. Baranov, and A. V. Lavrov,A. Sigov, E. Mishina,G. Fedorov,Giant Optical Activity Rosenman,Th. Rasing,Strong of Quantum Dots, Rods, and Thermo-Induced Single Disks with Screw Dislocations, And Two-Photon Green Scientific Reports,-,-, (2015). Luminescence In Self- 223. Tal Yoetz-Kopelman; Carmit Organized Peptide Microtubes, Porat-Ophir,; Yosi Shacham- Small,11,1156–1160 , (2015). Diamand,; Amihay Freeman, 229. Micha Kornreich, Eti Malka- ,Whole-Cell Amperometric Gibor, Adi Laser-Azogui, Ofer Biosensor for Screening of Doron, Harald Herrmann, Roy Cytochrome P450 Inhibitors, Beck,Composite bottlebrush Sensors & Actuators: B. Chemical mechanics: α-internexin ,N/A,8, (2015). fine-tunes neurofilament 224. Lior Medina, Rivka Gilat, network properties, Soft Robert Illic, Slava Krylov, matter,11,5839-5849, (2015). Experimental investigation of 230. Dan Ben-Yaakov, Roman the snap-through buckling of Golkov, Yair Shokef, and
88 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY Spinoffs
Startups • NoAm ColorTech (2013) - A startup combination of fibers. Lead company developing novel hair researcher: Prof. Shlomo Ruschin • NanoLock (2015) - NanoLock’s coloring using unique strongly • Variantyx Ltd. (2014) – Clinical technology enables any solid-state adhering coating beads. Lead grade, end-to-end genome memory to be physically “locked,” researcher: Prof. Amihay Freeman preventing unauthorized access at analysis services for physicians the hardware level. Furthermore, • Savicell Diagnostics (2012) - A and hospitals worldwide. Lead complete functionality of CPUs cancer diagnostic kit. Lead researcher: Dr. Noam Shomron researcher: Prof. Fernando Patolsky and MicroControllers can also • Hall Effect Multi-bit magnetic be “locked” and disabled. Lead • Quiet Therapeutics (2010) - A random access memory (MRAM), researcher: Prof. Slava Krylov startup company developing a signed with Samsung Global • NanoAir (2014) - A startup drug delivery technology. Lead MRAM Innovation. Lead researcher: company developing paper-thin researchers: Prof. Rimona Margalit Prof. Alexander Gerber (2014) and Prof. Dan Peer active cooling for thin devices. • PEG-dendrimer hybrids as novel Lead researchers: Prof. Slava Krylov • Tracense Systems (2010) - A startup nano-carriers for pesticides and Prof. Yosi Shacham company developing a nanotech- delivery, signed with Makhteshim • Cine’al (2014) - A startup company based “electronic nose” to sniff Chemical Works LTD. Lead developing jellyfish-derived super out security threats like bombs, researcher: Dr. Roey J. Amir (2014) biological warfare agents and absorbents for fluids, with a focus • A novel approach to fuel marking, toxic liquids. Lead researcher: Prof. on absorbing blood and proteins. signed with Eurocontrol Technics Fernando Patolsky Lead researcher: Prof. Shachar Group Inc. (TSX Venture: EUO). Richter Lead researcher: Prof. Fernando • Honeycomb Battery (2014) – A License Agreements Patolsky (2014) startup company based on • Discrimination of white blood cell • Aerie Pharmaceuticals (2015) 3D concentric on-chip silicon populations with label-free digital - First-in-class therapies for anti- microbattery technology, enabling holographic microscopy, signed beta amyloid small molecules for fabrication of 10-30K microbattery with Siemens AG. Lead researcher: the treatment of patients with units in the perforated chip. Dr. Natan Tzvi-Shaked (2014) glaucoma and dry AMD and other Lead researchers: Prof. Diana eye diseases. Lead researcher: Prof. • Optical interferometry microscopy Golodnitsky, Prof. Emanuel Peled Ehud Gazit system and algorithms for non- and Prof. Menachem Nathan destructive optical inspection, • Dexcel Pharma Technologies (2015) • StoreDot Ltd. (2013) is a leader signed with Applied Materials Israel – Parkinson’s disease therapy, in the innovation of materials Ltd. Lead researcher: Dr. Natan Tzvi- based on the identification of and their device applications, Shaked (2014) new beta-synuclein recognition developing groundbreaking modules. This disease-modifying • Electrochemical deposition of technologies based on a treatment may enable inhibition hydroxyapatite on dental implants, unique methodology for the of disease progression, in contrast signed with SGS International Ltd. design, synthesis and tuning to current symptomatic therapy Lead researcher: Prof. Noam Eliaz of new organic compounds. that does not arrest disease (2014) These proprietary compounds progression. Lead researcher: Prof. dramatically improve the • Nonpharma, polypeptide Ehud Gazit performance of a range of devices, nanostructures for use in products including batteries, displays, • Civan Advanced Technology of field effect transistors, signed sensors and digital memory. Lead (2015) - Development of a high- with The Technical University of researcher: Prof. Gil Rosenman power laser based on the coherent Denmark (DTU). Lead researcher: Prof. Ehud Gazit (2013)
89 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY SPINOFFS
• Fluorescent nanomaterial for • New hair coloring products based • Transparent conductive coating product authenticity verification, on unique coating beads which with nanowires for flat panel signed with Tata Steel Ltd. Lead strongly adhere to the hair surface, applications, signed with Nepes. researcher: Prof. Gil Markovich signed with NoAm ColorTech Lead researcher: Prof. Gil Markovich (2013) Ltd. Lead researcher: Prof. Amihay (2012) Freeman (2013) • Phenylalanine fibrils antibodies • A new drug for Parkinson’s disease, related to PKU, signed with EMD • Improving laser efficiency in OPO signed with Bioline Rx. Lead Millipore Corporation. Lead laser systems for airborne defense researcher: Prof. Ehud Gazit (2012) researcher: Prof. Ehud Gazit. (2013) systems against heat-seeking • Peptide nanotube electrodes for missiles, signed with Elbit Systems- • New drugs to treat schizophrenia energy storage applications, signed Elop. Lead researcher: Prof. Ady Arie and bipolar disorder, signed with with an Israeli defense industry (2012) Mental‐Heal Ltd. Lead researchers: company. Lead researchers: Prof. Prof. Moshe Portnoy, Prof. Avi • Coral-derived collagen for Ehud Gazit and Prof. Gil Rosenman Weizman and Dr. Irit Gilad (2013) tissue engineering, signed with (2010) ExceeMatrix Ltd. Lead researcher: • Targeted cancer therapy based • Transparent conducting nanowires, Prof. Dafna Benayahu (2012) on miR‐21, signed with Tickro signed with an Israeli startup in Technologies. Lead researchers: • Drug-eluting composite structures, the field of photovoltaic coatings. Dr. Ella Sklan and Dr. Rina Rosin- signed with Active Healing Bio Lead researcher: Prof. Gil Markovich Arbesfeld (2013) Medical Ltd. Lead researcher: Prof. (2009) Meital Zilberman (2012)
90 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY Staff
Core Staff Prof. Yael Hanein Director Mr. Zvi Kopolovitch Managing Director Ms. Michal Shenhar Administrative Director Dr. Yigal Lilach Electron & Ion Beam Lithography & Microscopy Manager Dr. Artium Khatchatouriants Bio-AFM Laboratory Manager Mr. Valery Gerber Process Engineer & Business Development Dr. David Schreiber Process Engineer Dr. Netta Handler Process Engineer Mr. Gidon Jacob Equipment Engineer Mr. Yoav Benjamin Equipment Engineer Mr. Yuval Kupitz Head of International Collaborations Dr. Inbal Halevi FTA Manager Ms. Noa Shafir Secretary
91 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY CENTER FOR NANOSCIENCE & NANOTECHNOLOGY
Core Members Prof. Shachar Richter Department of Materials Science and Engineering Prof. Yael Hanein School of Electrical Engineering Prof. Fernando Patolsky School of Chemistry Prof. Koby Scheuer School of Electrical Engineering Prof. Dan Peer Faculty of Life Sciences Prof. Roy Beck-Barkai School of Physics & Astronomy
Scientific Committee Prof. Ori Cheshnovsky School of Chemistry (Chairperson) Prof. Rimona Margalit Faculty of Life Sciences Prof. Yoram Dagan School of Physics & Astronomy Prof. Yael Hanein School of Electrical Engineering (Director) Prof. Fernando Patolsky School of Chemistry Prof. Dan Peer Faculty of Life Sciences Prof. Jacob Scheuer School of Electrical Engineering Dr. Inna Slutsky Faculty of Medicine Prof. Amit Kohn Department of Materials Science and Engineering
92 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY Acknowledgments
• The Chaoul Center for Nanoscale Materials and Systems
• The Marian Gertner Institute for Medical Nanosystems
• Vinci Technologies (Mr. Renaud Presberg)
• The Delaudaio Family (Argentina)
• Ms. Sara Weis (Australia)
• Mr. Shlomo Eliahu (Israel)
• Mr. Eli Horn (Brazil)
• Mr. Robert Goldberg (USA)
• James Russell DeLeon – The Center for Nanostructuring
• The Jack H. Skirball National Center for Biomedical Nanoscience
• Nanotechnology Research Fund in Cooperation with Clal Biotechnical Industries
• The Ilona Rich Institute for Nanoscale Bioscience and Biotechnologyv
• The Dr. Teodoro Jack and Dorothea Krauthamer Laboratory for Scanning Electron Microscopy
• A.V.B.A. Students Laboratory for Electron Beam Lithography
• Infrastructure Equipment for Nanotechnology Research - Wolfson Family Charitable Trust (UK)
• The Raymond and Beverly Sackler Chair in Clusters and Nanoparticles
• The Edouard Seroussi Chair for Protein Nanobiotechnology
• The Herman and Kurt Lion Chair in Nanosciences and Nanotechnologies
• The Bernard L. Schwartz Chair and Program in Nanoscale Information Technology
• Support for Nanotechnology Research donated by The Gilman Foundation
• Walanpatrias Stiftung
• Pa’amei Tikva Nanotechnology Research Fund (Israel 2004) LTD
93 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY Scholarships
• Mr. Ezekiel Solomon (Australia)
• The Cohen Family Doctoral Fellowship for the Study of Nanoscience
• The Buchman Heyman Foundation
• The Herb and Sharon Glaser Foundation
• Mr. Brian Lieber (UK)
• Mr. Doron Kochavi (Israel)
Since 2007 the Center is generously supported by the Israel Nanotechnology National Initiative (INNI) program, founded by TELEM (2007-2016)
94 THE CENTER FOR NANOSCIENCE & NANOTECHNOLOGY AT TEL AVIV UNIVERSITY