MESSAGE FROM DR. GRAYDON MENEILLY……………………………………………3 MISSION STATEMENT………………………………………………………………………..7 ORGANIZATION CHART……………………………………………………………………. 9 UBC DEPARTMENT OF MEDICINE COMMITTEE STRUCTURES…………………..11 UBC DEPARTMENT OF MEDICINE ADMINISTRATIVE OFFICE……………………13 UBC DEPARTMENT OF MEDICINE COMMITTEES……………………………………15 Department Heads, Associate Heads, UBC Division Heads, Educational Program Directors & Associate Directors………………………………………….17 Research………………………………………………………………………………………….19 Committee for Appointments, Reappointments, Promotion and Tenure……………………….. 21 Teaching Effectiveness Office………………………………………………………………….. 25 DIVISION REPORTS.…………………………………………..………………………….… 27 AIDS…………………………………………………………………………………………….. 29 Allergy & Immunology…………………………………………………………………………. 35 Cardiology.……………………………………………………………………………………….41 Community Internal Medicine………………………………………………………………….. 55 Critical Care Medicine…………………………………………………………………….……. 61 Endocrinology……………………………………………………………………………………67 Gastroenterology.……………………………………………………………………………..….71 General Internal Medicine………………………………………………………………………. 79 Geriatric Medicine………………………………………………………………………………. 85 Hematology………………………………………………………………………………………91 Infectious Diseases……………………………………………………………………………..... 95 Medical Oncology…………………………………………………………………………….... 101 Nephrology…………………………………………………………………………………...... 107 Neurology……………………………………………………………………………………….115 Physical Medicine & Rehabilitation…………………………………………………………… 135 Respiratory Medicine…………………………………………………………………………... 141 Rheumatology………………………………………………………………………………….. 147 Department of Medicine Members at Large………………………………………………...... 153 EDUCATIONAL PROGRAMS……………………………………………………………... 155 AIDS Research Program……………………………………………………………………….. 157 Clinical Investigator Program………………………………………………………………….. 175 Continuing Medical Education Program………………………………………………………. 181 Graduate Studies Program in Experimental Medicine…………………………………………. 183 Postgraduate Education Program………………………………………………………………. 187 Undergraduate Education Program…………………………………………………………….. 189 PUBLICATIONS……………………………………………………………………………... 193 GRANTS AND RESEARCH AWARDS……………………………………………………. 263

UBC Department of Medicine Page 1 Annual Report 2007

Message from Dr. Graydon Meneilly

Graydon S. Meneilly, MD, FRCPC Eric W. Hamber Professor & Head Department of Medicine UBC & Vancouver Acute

I am pleased to provide this overview for the 2007 annual report on behalf of the UBC Department of Medicine. This report is also available online at www.medicine.ubc.ca.

Overview

The UBC Department of Medicine provides research, teaching and clinical services related to the nature, cause and prevention of adult diseases. We are the largest department in the Faculty of Medicine and we consist of 17 divisions: AIDS, Allergy and Immunology, Cardiology, Community Internal Medicine, Critical Care Medicine, Endocrinology, Gastroenterology, Geriatric Medicine, Hematology, Infectious Diseases, Internal Medicine, Medical Oncology, Nephrology, Neurology, Physical Medicine and Rehabilitation, Respiratory Medicine and Rheumatology.

Members

As you read through this document you encounter the many different aspects of our Department and the things we have achieved over the past year. I would like to take this opportunity to highlight some of the many wonderful accomplishments of our members. In particular I would like to highlight the contributions of Dr. Paul Man, Associate Head of Medicine at UBC and Chair, Department of Medicine at Providence Health Care. He is absolutely integral to the function of the Department and all of our strategic initiatives.

Recruitment and retention are a large part of our business. In 2007, we appointed 4 Professors, 3 Assistant Professors, 2 Associate Professors, 1 Clinical Professor, 1 Clinical Associate Professor, UBC Department of Medicine Page 3 Annual Report 2007 32 Clinical Assistant Professors, 16 Clinical Instructors, 1 Adjunct Professor and 2 Associate Members, and we promoted 37 faculty members.

In 2007, our faculty received 52 CIHR Scholarship/Scientist awards, 42 Michael Smith Scholarships/Scientist awards, 7 CRC Scientist awards and 3 Medical Research Council of Canada awards.

In 2007 the Department had several changes in divisional leadership. I am very pleased to announce the appointments of the following division heads:

• Dr. Julio Montaner, UBC Division of AIDS – April 5, 2007 • Dr. Ehud Ur, UBC Division of Endocrinology – September 1, 2007 • Dr. Andrea Townson, UBC Division of Physical Medicine & Rehabilitation – November 1, 2007

I wish to express a sincere thank you to both Dr. David Thompson, who stepped down from his role as Head of the Division of Endocrinology, and Dr. Theo van Rijn, who stepped down from his role as Head of the Division of Physical Medicine and Rehabilitation, for all of their efforts on behalf of the department.

I am very pleased to announce the creation of the Division of AIDS within the Department of Medicine. This is the first Division of AIDS in Canada. In the last 20 years and particularly during the last decade, HIV/AIDS has become the fastest growing field of medicine in terms of research, therapy and service delivery methods. The time has come for this important field of medicine to be formally acknowledged within the academic structure of the University of British Columbia. This new division will bring together, enhance and expand the research, training, service delivery and administration that have evolved over the last two decades within UBC.

Awards

The Department extends its warmest congratulations to these outstanding individuals who received the following Departmental awards: The Fay R. Dirks Awards for Excellence in Teaching were awarded to Drs. Phil Teal (Neurology) and Irene Ma (Internal Medicine); The Martin M. Hoffman Awards for Excellence in Research were awarded to Drs. Jason Barton (Neurology) and Julio Montaner (AIDS); The Donald M. Whitelaw Awards for Outstanding Grand Rounds were given to Drs. Neil Reiner (Infectious Diseases) and Jake Onrot (Internal Medicine); The Master Teacher Awards were given to Drs. Frank Ryan (Respiratory Medicine) and Richard Arseneau (Internal Medicine).

In addition, members of the department were recognized by the Faculty of Medicine and other bodies for their excellence in teaching and research. Some of the special honours and awards received by our members in 2007 are: Dr. John Cairns (Cardiology) was awarded the UBC Faculty of Medicine Distinguished Achievement Award for Outstanding Contributions by a Senior Faculty Member, the Canadian Society for Clinical Investigation Distinguished Services Award, and also the Canadian Association of Professors of Medicine Ronald Christie Award for Outstanding Contributions to Academic Medicine in Canada; Dr. Julio Montaner (AIDS) was the recipient of the BC Innovation Council’s Science & Technology Champion of the Year Award UBC Department of Medicine Page 4 Annual Report 2007 for leadership in HIV/AIDS clinical research, and also the Faculty of Medicine’s Distinguished Achievement Award for Overall Excellence; Dr. Adeera Levin (Nephrology) received the The National Kidney Foundation’s Garabed Eknoyan Award for outstanding contributions in kidney disease research; Dr. Jon Stoessl (Neurology) was awarded the Order of Canada; Dr. Roger Wong (Geriatric Medicine) was honoured, for the fifth consecutive year, with the Alzheimer Society of BC’s Award of Appreciation, and was also the recipient of the Donald Richards Wilson Award for excellence in medical education from the Royal College of Physicians and Surgeons of Canada in collaboration with Associated Medical Services, Inc.; Dr. Diane Lacaille received the Quality of Life Research Award from the Institute of Musculoskeletal Health & Arthritis (IMHA); Dr. Don Sin (Respiratory Medicine) received the Distinguished Achievement Award for Research Excellence from the Faculty of Medicine; Dr. Evan Wood (AIDS) was the recipient of the Canadian Medical Assocation’s Award for Young Leaders.

One of the Department's most important strategic initiatives is the creation of the Academic Enhancement Endowment Fund and the Academic Enhancement Fund competition process. These awards are provided in an effort to ensure greater protected research time for individuals undertaking meritorious research. This fund has taken on greater importance as the endowment has grown and as the awards have increased. The recipients of the Academic Enhancement Endowment Fund awards in 2007 were Drs. Philip Lee (Geriatric Medicine) and John Swiston (Respiratory Medicine). Recipients are termed Departmental Scholars.

Clinical

The foundation of all activities in a Department of Medicine is exemplary patient care. Maintaining the highest quality of care has been challenging due to resource constraints, but our members continue to provide excellent care to the citizens of Vancouver and the province of British Columbia.

Research

Once again the department was extremely successful in attracting research support. The department received $26,105,585 in peer reviewed grants and $14,617,875 in non-peer reviewed grants.

The number of high profile peer reviewed papers by members of the department continues to increase. The department published more than 900 peer reviewed papers in the last year in journals of the highest impact including the New England Journal of Medicine, JAMA and many others. These research contributions highlight the fact that many groups within the department are among the best in the world in their area of expertise.

UBC Department of Medicine Page 5 Annual Report 2007 Teaching

Our medical school has doubled in size and we have implemented a unique model of distributed education. Our undergraduate program is a distributed program with satellite offices in Chilliwack, Prince George and Victoria. In September 2007, the Department of Medicine third year clinical clerkship expanded to include an additional 24 third year medical students in the Vancouver Fraser Medical Program. In February 2007 the postgraduate program underwent a Royal College Accreditation Review where we received full approval. July 2007 saw the largest number of MOH funded residency positions to-date. With 39 PGY-1 positions through CaRMS, 2 re-entry physicians and 3 sponsored Internal Medical Graduates we continue to be the second largest Internal Medicine Training Program in Canada, and we continue to attract the highest quality trainees from around the country.

Summary In closing I would like to take this opportunity to once again acknowledge the contributions of all faculty and staff and to thank them for their hard work, outstanding achievements and dedication to the success of the Department of Medicine.

Sincerely,

Graydon S. Meneilly, MD, FRCPC Eric W. Hamber Professor & Head UBC Department of Medicine

UBC Department of Medicine Page 6 Annual Report 2007

MISSION STATEMENT

We, the members of the Department of Medicine of the University of British Columbia, will work with all our partners to provide the highest possible standard of excellence in patient care, teaching and research. We will pursue this mission while emphasizing open communication and ethical behavior, and while recognizing that it is a privilege to provide responsible and innovative stewardship of human, financial and all other resources. We will always:

• respect the dignity, individuality and needs of our patients,

• strive to discover new knowledge that will advance state-of-the- art care,

• ensure effective and innovative teaching of our students,

• optimize our organization to promote both professional and personal fulfillment,

• value the efforts and achievements of teams and individuals who work to face the challenges of modern medicine.

These activities will ensure the respect of our peer organizations and recognition as a world-class Department of Medicine.

UBC Department of Medicine Page 7 Annual Report 2007

ORGANIZATION CHART

Dean UBC Faculty of Medicine

Head UBC Department of Medicine

Associate Heads, Heads & Directors of Divisions UBC Dept. of Medicine & Programs of UBC Heads, Hosp. Dept. of Medicine Department of Medicine

Heads & Directors of Divisions & Programs of the Hospital Departments of Medicine

Members, Divisions & Programs of the Hospital Departments of Medicine

UBC Department of Medicine Page 9 Annual Report 2007

UBC DEPARTMENT OF MEDICINE COMMITTEE STRUCTURES

Head UBC Department of Medicine

Academic Appointments Executive Committee UBC Quarterly / Reappointments Promotion & Tenure Committee

Teaching Effectiveness UBC Division Heads UBC Educational All Faculty Committee Program Directors

Aids Hematology Continuing Medical Education

Allergy & Immunology Infectious Diseases Graduate/Experimental Medicine

Cardiology Medical Oncology Postgraduate

Community Internal Nephrology Undergraduate Medicine

Critical Care Medicine Neurology Clinical Investigator Program

Endocrinology Physical Medicine & Rehabilitation

Gastroenterology Respiratory Medicine

General Internal Rheumatology Medicine

Geriatric Medicine

UBC Department of Medicine Page 11 Annual Report 2007

UBC DEPARTMENT OF MEDICINE – ADMINISTRATION OFFICE

Department Head Division Heads Associate Heads

Administration Undergraduate Postgraduate Experimental Clinical Continuing Director Program Program Medicine Program Investigator Medical Director Director Director Program Education Directors Director

Associate Information Human Finance Undergraduate Program Continuing Technology Resources Manager Program Directors Medical Systems Manager Administrator Education Consultant Administrator Postgraduate Faculty Hires Finance Clerk Admin. Asst. Undergraduate Administrator Experimental Clinical & Promotions (UBC) Program Medicine Investigator Coordinator Secretary (VGH) Program Program Secretary Secretary (SPH) (40%) HR Assistant MOH Clerk Admin. Asst. Undergraduate Postgraduate (Staff) (60%) (Hospital) Program Program Secretary (SPH) Assistant

HR Assistant (Faculty) CV Postgraduate Secretary / Program Secretary, Secretary Assoc. Head, Receptionist Research Postgraduate Program Secretary (SPH) (40%) UBC DIVISIONS

AIDS Endocrinology Hematology Neurology Allergy & Immunology Gastroenterology Infectious Diseases Physical Medicine & Rehabilitation Cardiology General Internal Medicine Medical Oncology Respiratory Medicine Community Internal Medicine Geriatric Medicine Nephrology Rheumatology Critical Care Medicine UBC Department of Medicine Page 13 Annual Report 2007

UBC DEPARTMENT OF MEDICINE COMMITTEES

UBC Department of Medicine Page 15 Annual Report 2007

DEPARTMENT HEADS, ASSOCIATE HEADS, UBC DIVISION HEADS, EDUCATIONAL PROGRAM DIRECTORS & ASSOCIATE DIRECTORS

DEPARTMENT HEADS

Graydon S. Meneilly, MD, FRCPC Eric W. Hamber Professor & Head Department of Medicine, UBC & VGH

S. F. Paul Man, MD, FRCPC Chair, Department of Medicine Providence Health Care

UBC ASSOCIATE HEADS

Dr. Michael Barnett, Associate Head of Medicine, Vancouver Acute Dr. S. F. Paul Man, Associate Head of Medicine, Providence Health Care Dr. Don Sin, Associate Head Research

UBC DIVISION HEADS

AIDS Dr. Julio Montaner Allergy & Immunology Dr. Robert Schellenberg Cardiology Dr. Chris Buller Community Internal Medicine Dr. Barry Kassen (Acting) Critical Care Medicine Dr. Dean Chittock (Acting) Endocrinology Dr. David Thompson (January 1 – August 31, 2007) Dr. Ehud Ur (September 1, 2007 - ) Gastroenterology Dr. Eric Yoshida General Internal Medicine Dr. Barry Kassen Geriatric Medicine Dr. Janet McElhaney Hematology/Bone Marrow Transplantation Dr. Michael Barnett Infectious Diseases Dr. Neil Reiner Medical Oncology Dr. Susan O'Reilly Nephrology Dr. Paul Keown Neurology Dr. Howard Feldman Physical Medicine & Rehabilitation Dr. Theo Van Rijn (January 1 – October 31, 2007) Dr. Andrea Townson (November 1, 2007 - ) Respiratory Medicine Dr. Mark FitzGerald Rheumatology Dr. John Esdaile (Acting)(July 1 – December 31, 2007) Dr. Barry Koehler (Acting)(January 1 – June 30, 2007)

UBC Department of Medicine Page 17 Annual Report 2007

EDUCATIONAL PROGRAM DIRECTORS & ASSOCIATE DIRECTORS

Clinical Investigator Program Director Dr. Anita Palepu

Continuing Medical Education Director Dr. G. B. John Mancini

Graduate Studies Program in Dr. Vince Duronio Experimental Medicine Director

HIV/AIDS Research Program Director Dr. Julio Montaner

Postgraduate Education Program Dr. J. Mark Roberts Director

Associate Directors Dr. Roger Wong Dr. Irene Ma Dr. Barry Kassen

Undergraduate Education Program Director Dr. Grant Stiver

Associate Directors Dr. Jim Dunne, 3rd year Clerkship Director & Program Director, CTU, VGH Dr. Jim Busser, Program Director, CTU, VGH Dr. Abeed Jamal, 4th year Clerkship Director Dr. Janet Kushner-Kow, Associate Director, Expansion & New Programs

UBC Department of Medicine Page 18 Annual Report 2007

RESEARCH

Don D. Sin, MD Associate Professor & Associate Head, Research

In November 2006, Dr. Don Sin accepted the position of Associate Head, Research. Dr. Sin is a clinician-scientist who holds a Canada Research Chair (in COPD), UBC/GSK/St. Paul’s Hospital Foundation Professorship in COPD and is a senior scholar with the Michael Smith Foundation for Health Research.

His primary interest has been in promoting and fostering the development of clinician-scientists in the department through early exposure of medical residents to clinical research, enhancing the interaction of medical residents with clinician-scientist mentor and in assisting the transition of young academic faculty members from post-doctoral fellowship to their new faculty positions.

In June, 2006, a monthly clinical seminar series was initiated at St. Paul’s Hospital to increase the exposure of established clinician-scientists to medical residents and students. To date, the seminar series has featured a distinguished list of speakers including Drs. Keith Walley, Robert Schellenberg, James Hogg, Najib Ayas, Karin Humphries, Adeera Levin, Paul Man, Tony Bai, and Bruce McManus. The seminar series has been well received by the audience with feedback comments such as “(the talk has made) the idea of research clinician area more appealing/useful”, “What an interesting topic! How very relevant to what we do...”, “Great introduction to research…” and the like.

Secondly, beginning in September of 2007, an academic half-day was introduced to promote the career of a clinician scientist in medicine, which was well received by the medical residents. Thirdly, an ad hoc research committee was formed in 2006-7 to develop a set of strategic objectives for the department. A preliminary draft of the report has been generated and a final version is expected later on this year. Fourthly, Dr. Sin has been working with the department chair to develop a more equitable (and more balanced) distribution of start-up funding to new recruits for the department. The various proposals are under discussion within the department executive committee to optimize the allocation of these scarce resources. Finally, Dr. Sin has been working with Elizabeth Cheu, a newly hired research grant development officer, to assist new recruits in grant writing and in enhancing their success rates with peer-reviewed grants.

UBC Department of Medicine Page 19 Annual Report 2007

COMMITTEE FOR APPOINTMENTS, REAPPOINTMENTS, PROMOTIONS AND TENURE

Chair: Dr. G. S. Meneilly, Professor Vice-Chair: Dr. S. F. Paul Man, Professor (since July 1, 2006) Administrative Secretary: Jeannie Brown (Jan-June 2007) and Amy Poon (June-Dec 2007)

Dr. Yossef Av-Gay, Associate Professor, Infectious Diseases Jan 2007 to Dec 2007 Dr. Tony Bai, Professor, Respiratory Medicine Jan 2007 to Dec 2007 Dr. Michael Barnett, Clinical Professor, Hematology Jan 2007 to Dec 2007 Dr. John Cairns, Professor, Cardiology Jan 2007 to Dec 2007 Dr. Marshall Dahl, Clinical Associate Professor, Endocrinology Oct 2007 to Dec 2007 Dr. John Esdaile, Professor, Rheumatology July 2007 to Dec 2007 Dr. Paul Hoskins, Clinical Professor, Medical Oncology Jan – Jun 2007, Oct – Dec 2007 Dr. Simon Huang, Clinical Associate Professor, Rheumatology Jan 2007 to Dec 2007 Dr. Barry Kassen, Clinical Professor, General Internal Medicine Jan 2007 to Dec 2007 Dr. Paul Keown, Professor, Nephrology Jan 2007 to June 2007 Dr. Nasreen Khalil, Clinical Professor, Respiratory Medicine Jan 2007 to Dec 2007 Dr. G. B. J. Mancini, Professor, Cardiology Jan 2007 to June 2007 Dr. Janet McElhaney, Professor, Geriatric Medicine Jan 2007 to Sep 2007 Dr. Nevin Murray, Clinical Professor, Medical Oncology Jan 2007 to Dec 2007 Dr. Joel Oger, Professor, Neurology Oct 2007 to Dec 2007 Dr. Donald Ricci, Clinical Professor, Cardiology Jan 2007 to Dec 2007 Dr. Frank Ryan, Professor, Respiratory Medicine July 2007 to Dec 2007 Dr. Robert Schellenberg, Professor, Allergy & Immunology Jan 2007 to Dec 2007 Dr. Kamran Shojania, Clinical Associate Professor, Rheumatology July 2007 to Dec 2007

This dedicated group of committed Departmental members is charged with facilitating the career advancement of our members while upholding consistent and rigorous standards as set out by UBC. As usual, this Committee invested a great deal of thoughtful energy to support the additions and promotions listed below. We are very proud of the following:

NEW APPOINTMENTS

Adjunct Professor Le Page, Judy - Rheumatology

Associate Member Hollohan, Kirk – General Internal Medicine Purtzki, Jacqueline – Physical Medicine & Rehabilitation

Assistant Professor Carlsten, Christopher – Respiratory Medicine Jacova, Claudia - Neurology Swiston, John – Respiratory Medicine

UBC Department of Medicine Page 21 Annual Report 2007

Associate Professor Krassioukov, Andrei – Physical Medicine & Rehabilitation Harrigan, Richard – AIDS

Professor Francis, Gordon - Endocrinology Illes, Judy – Neurology Rieckmann, Peter – Neurology Ur, Ehud - Endocrinology

Clinical Instructor Alimoradi, Ima – Geriatric Medicine Chung, Henry - Gastroenterology Collins, David – Rheumatology Fam, Ezz – Community Internal Medicine Finlayson, Heather – Physical Medicine & Rehabilitation Ho, Jin Kee – Gastroenterology Klinke, Jennifer – Associate of Endocrinology Kur, Jason – Rheumatology Lee, Julie – Associate of Endocrinology McCormick, Iain – General Internal Medicine Medvedev, George – Associate of Neurology Qureshi, Tariq – Community Internal Medicine Ramadan, Khaled – Hematology Reebye, Rajiv – Physical Medicine & Rehabilitation Shu, David – Endocrinology Virani, Sean - Cardiology

Clinical Assistant Professor Aminbakhsh, Amin – Associate of Cardiology Arikan, Yasemin – Community Internal Medicine Ashton, Tom – Associate of Cardiology Collier, Todd – Associate of Neurology Forbes, Anastasia – Associate of Geriatric Medicine Fretz, Eric – Associate of Cardiology Friesen, Marlyce – Associate of Nephrology Hayden, Sherri – Neurology Ho, Cheryl – Medical Oncology Ho, Kennely – Associate of Neurology Iqbal, Zafar – Community Internal Medicine Jones, Christopher – Associate of Nephrology Kennecke, Hagen – Medical Oncology Kommareddy, Aruna – Medical Oncology Kwan, Susan – Associate of Respiratory Medicine Lam, Sui Sang (George) – Associate of Nephrology MacCarthy, John – Associate of Respiratory Medicine

UBC Department of Medicine Page 22 Annual Report 2007

Martinka, Grzegorz (Greg) – Associate of Critical Care Medicine McKee, Scott – Community Internal Medicine Oyler, Jeffrey – Associate of Neurology Pearson, David – Gastroenterology Penner, Robert - Gastroenterology Phillips, Barrie – Community Internal Medicine Pick, Neora – Infectious Diseases Pullen, Brock - – Associate of Gastroenterology Schwartz, Daniel – Associate of Nephrology Spacey, Sian – Neurology Starko, Robert – Associate of Neurology Sutcliffe, Stephen – Community Internal Medicine Tinker, Anna – Medical Oncology Varadarasa, Arul – Community Internal Medicine Webster, Sheila – Associate of Respiratory Medicine

Clinical Associate Professor Paty, Breay – Endocrinology

Clinical Professor Klinke, Peter – Associate of Cardiology

PROMOTIONS

Associate Professor Ayas, Najib – Respiratory Medicine Dorscheid, Delbert – Critical Care Medicine Gill, John – Nephrology Humphries, Karin – Cardiology Steiner, Ted – Infectious Diseases

Professor Yoshida, Eric - Gastroenterology

Clinical Assistant Professor Bashir, Khalid – Community Internal Medicine Bozek, Christopher – Neurology Chatur, Nazira – Gastroenterology Fung, Michelle – Endocrinology Kanani, Amin – Allergy & Immunology Koziol, Kathie – Associate of Gastroenterology Kushner-Kow, Janet – Geriatric Medicine Lam, Eric – Gastroenterology Leger, Chantal – Hematology Murphy, Colleen – Neurology Ramji, Alnoor – Gastroenterology

UBC Department of Medicine Page 23 Annual Report 2007

Reynolds, Robert – Infectious Diseases Sreenivasan, Gayatri – Hematology Wojtowska, Ewa – Community Internal Medicine Yao, Jennifer – Physical Medicine & Rehabilitation

Clinical Associate Professor Enns, Robert – Gastroneterology Jue, John – Cardiology Kendler, David – Endocrinology Roberts, Mark – General Internal Medicine Shuckett, Rhonda – Rheumatology Wong, Roger – Geriatric Medicine

Clinical Professor Carere, Ron – Cardiology Fung, Anthony – Cardiology Kiess, Marla – Cardiology Nakielna, Barbara – Respiratory Medicine Onrot, John (Jake) - General Internal Medicine Reid, Graham – Rheumatology Ronco, Juan – Critical Care Medicine Teal, Philip – Neurology Vickars, Linda – Hematology Yeung-Lai-Wah, John - Cardiology

REAPPOINTMENTS

Assistant Professor Cibere, Jolanda – Rheumatology Cook, Victoria – Respiratory medicine Gill, Sharlene – Medical Oncology Hmama, Zakaria – Infectious Diseases Hsiung, Robin – Neurology Savage, Kerry – Medical Oncology Towle, Angela Tremlett, Helen – Neurology

Associate Professor McKeown, Martin – Neurology

EMERITUS STATUS Bernstein, Victoria – Cardiology Chan, Victor – Nephrology Hahn, George – Physical Medicine & Rehabilitation MacDonald, Ian – Cardiology

UBC Department of Medicine Page 24 Annual Report 2007

TEACHING EFFECTIVENESS OFFICE

Dr. James Busser Chair; Member, UBC Division of General Internal Medicine

Mrs. Jennifer Golinski Administrator; Undergraduate Education, UBC Department of Medicine

Ms. Katya Leonardia Program Assistant, Undergraduate Education, UBC Department of Medicine

Ms. Amy Poon Faculty Hires and Promotions Coordinator, UBC Department of Medicine

Reports to: Committee for Appointments, Reappointments, Promotions and Tenure

Functions:

1. Provides Faculty member with "Guidelines" for producing necessary back-up documentation to Teaching Dossier.

2. Meets with Faculty member to discuss necessary back-up documentation and the process entailed for the teaching and education component of promotion/tenure/reappointment.

3. Liaises with various program offices: Undergraduate, Postgraduate, Continuing Medical Education, Graduate Studies to obtain information regarding contributions to education, including teaching effectiveness, of candidate. Where necessary, requests additional peer review of teaching.

4. Reviews teaching dossier, back-up documentation, peer review and prepares draft report for Committee for Appointments, Reappointments, Promotions and Tenure.

5. Forwards draft report to Faculty member to ensure that feedback appears accurate and representative, and that important information has not been omitted.

6. Finalizes report and forwards to Committee for Appointments, Reappointments, Promotions and Tenure.

In the year 2006, the Teaching Effectiveness Committee prepared 42 letters on behalf of GFT and Clinical Faculty. Subsequent promotions for these faculty have included:

(2) Professor (6) Associate Professor (10) Clinical Professor (16) Clinical Assistant Professor UBC Department of Medicine Page 25 Annual Report 2007

(7) Clinical Associate Professor

Additionally, one letter was prepared for re-appointment.

In the year 2007, we met with another 49 faculty, and have prepared 49 letters to support their review and/or consideration of promotion.

UBC Department of Medicine Page 26 Annual Report 2007

DIVISION REPORTS

UBC Department of Medicine Page 27 Annual Report 2007

AIDS

Dr. Julio Montaner Professor & Head

Faculty Members

Professor Montaner, Dr. Julio SPH Assistant Professor Harrigan, Dr. Paul SPH Assistant Professor Kerr, Dr. Thomas SPH Clinical Assistant Professor Wood, Dr. Evan SPH

In April 2007, the Division of AIDS was created within the Department of Medicine. This newly established Division enhances our ability to attract and retain academic staff with the wide range of expertise needed to address this truly interdisciplinary challenge. This will also decrease the demands that the HIV/AIDS group has placed on the Division of Infectious Diseases, which naturally will continue to be involved in HIV/AIDS, but with a much more specific sub-specialty focus. Precedents for the establishment of such Division of AIDS exist in major universities in North America with the Division of AIDS at Harvard Medical School, headed by Dr. Bruce Walker, and the Division of AIDS at the San Francisco General Hospital/University of California, headed by Dr. Diane Havlir. The Division of AIDS at UBC is the first of its kind in Canada.

Under the leadership of Drs. Thomas Kerr and Evan Wood, the epidemiology group has been very productive and continues to benefit from long-term analyses emerging from VIDUS, SEOSI, ACCESS, ARYS, and MAKA cohorts. Dr. Thomas Kerr has received a New Investigator Award from the Canadian Institutes of Health. Other grant funding was obtained from the Michael Smith Health Research Foundation, Canadian Institutes of Health Research, National Institute of Health in the United States and a number of pharmaceutical companies.

Headed by Dr. Richard Harrigan, the research laboratory, based at the B.C. Centre for Excellence in HIV/AIDS (BC-CfE), has established itself not only as a leading force in Canada, but also as a centre with considerable international influence. The laboratory has provided clinical services to the province of B.C. in the areas of HIV drug resistance testing and pharmacokinetic measurement. The clinical implications and predictors of HIV drug resistance continue to be investigated, both at the BC-CfE and as part of international collaborations. The research laboratory focuses on developing tools with clinical applications that may be employed in the near future. These include techniques for monitoring the side effects and degree of adherence to

UBC Department of Medicine Page 29 Annual Report 2007

medications, as well as tracking variations in the HIV and human genomes which are associated with response to HIV therapy, and virus pathogenicity. In addition to providing HIV drug resistance testing as a clinical service to most of Canada and investigator-driven trials, the research lab has also received peer-reviewed funding for several studies from the Canadian Institutes of Health Research, Michael Smith Health Research Foundation, and the Ontario HIV Treatment Network. Dr. Richard Harrigan holds the Glen Hillson Professorship in Clinical Virology. Novel testing applications in the laboratory continue to provide testing support for Phase III clinical trials.

Under the direction of Dr. Julio Montaner, cutting-edge research continues within the clinical science group, focusing on the treatment of patients with multidrug-resistant virus, pharmacokinetics of antiretrovirals, optimizing adherence to antiretroviral therapy regimens, recognition and management of drug toxicities, management of viral co-infections, and primary care initiatives.

New and investigational agents continue to emerge which hold promise in the treatment of patients with multi-drug resistant HIV. In the past year, the clinical group has participated in clinical trials studying the use of investigational drugs from a number of new and old drug classes, including non-nucleoside reverse transcriptase inhibitors (etravirine), protease inhibitors (darunavir), integrase inhibitors (raltegravir), and CCR5 receptor antagonists (maraviroc), some of which have since been approved by Health Canada. A study was completed in 2007 examining the outcomes of multidrug-experienced and -resistant patients who switched from the fusion inhibitor enfuvirtide (administered as twice-daily subcutaneous injections) to the more patient- friendly raltegravir (a well-tolerated oral agent) within their antiretroviral regimen. The results were presented at a major conference (15th Conference on Retroviruses and Opportunistic Infections [CROI]. Boston, Massachusetts) in February 2008 and will be submitted for publication shortly. New fixed-dose combinations have also become available which simplify antiretroviral regimens and reduce their pill burden; for example, Truvada (tenofovir + FTC) has largely replaced the widely-used combination of tenofovir + 3TC. The clinical group presented a study in 2007 examining the adverse effects that can occur when patients make the switch from 3TC to FTC (in Truvada).

The clinical team continues to work in concert with the BC-CfE Laboratory to study the complex issues of pharmacokinetic interactions between antiretroviral drugs. One study presented in 2007 and currently being prepared for publication looked at the effect on lopinavir plasma levels of switching from high-dose Kaletra (lopinavir/ritonavir) capsules to the new formulation of Kaletra tablets. This was the first such study looking at this important issue which can affect multiple drug-experienced patients who need higher drug levels to overcome drug resistance. The Therapeutic Drug Monitoring program is accumulating a large database, which incorporates information on all HIV positive patients undergoing antiretroviral drug level testing in the province. Linkage of this information with the Drug Treatment Program database will enable us to explore the complex relationships between antiretroviral drug levels and drug efficacy and toxicity, with respect to demographic factors (e.g. gender, age, and ethnicity), comorbid conditions, concomitant medications and other factors. A major focus of the Centre has been the use and study of pharmacokinetics to optimize and individualize care. Ongoing research is

UBC Department of Medicine Page 30 Annual Report 2007

exploring factors which impact variability in the pharmacokinetics of these drugs such as gender, age and co-infection with hepatitis C.

The issues surrounding adherence to antiretroviral drug regimens are a topic of active study by the Psychology Team. This part-time team is presently involved in three projects: reviewing the data collection of the ARMS (Antiretroviral Readiness and Motivation Scale); interviewing and collecting data for a retrospective lipoatrophy study that is gathering information on the psychological and adherence impact of cosmetic interventions for facial lipoatrophy; and finishing the data collection for the HIV/HCV co-infection project. As well, the Psychology Team forms part of the IDC multidisciplinary team. This team provides adherence support for more than 100 patients and is involved in training of psychology interns.

Toxicities of antiretroviral therapy continue to be a major focus of research by the clinical group. Metabolic disorders including abnormalities of glucose metabolism and dyslipidemia are being studied in conjunction with colleagues in the Healthy Heart Program. Results of a randomized clinical trial looking at the effect of rosiglitazone on carotid intima media thickness (IMT), plaque area, and other markers of cardiovascular disease risk in antiretroviral-treated patients were presented in 2007 and are currently being prepared for publication. The protocol for a large study looking at one possible intervention to reduce cardiovascular risk in 250 antiretroviral-treated patients was finalized and received industry funding in 2007. This two-year study looking at the effect of rosuvastatin versus placebo on various markers of cardiovascular risk, including IMT, will commence enrollment across Canada in 2008. Also, completed in 2007 and presented at CROI in early 2008, was a large cross-sectional study examining the incidence of and risk factors for osteoporosis and osteopenia among 300 HIV-positive patients. This study identified an alarmingly high (67%) prevalence of abnormal bone mineral density among this unselected group of HIV+ individuals, and identified older age, lower CD4 cell count, and longer exposure to tenofovir as risk factors for bone disease in this population. These important findings will be followed up in a longitudinal study which is currently being designed.

Co-infection with hepatitis B and C continues to have a major effect on the HIV-infected clinic population. In conjunction with Dr. Helene Cote at UBC, the clinical group is actively enrolling HIV/HCV co-infected patients into a CIHR-funded study examining the effect of mitochondrial toxicity in the liver caused by HIV and hepatitis C treatment. In addition, a study is currently enrolling to examine the issue of suboptimal adherence to anti-hepatitis C treatment in HIV- positive patients. In addition, the BC group is participating in a national prospective HIV/HCV co-infection cohort.

Of note, the clinical team contributed chapters to three major textbooks published in 2007: Antiretroviral Therapy of Drug-Resistant HIV, in Global HIV/AIDS Medicine (Volberding et al.); HIV Infection, in Therapeutic Choices (Canadian Pharmacists Association); and Nevirapine, in AIDS Therapy (Dolin, Masur, and Saag).

Current Areas of Active Clinical Research • First-line antiretroviral therapy • Salvage therapy for patients with previous treatment failure and multiple drug-resistant HIV • Strategies for optimizing the use of investigational and newly available antiretroviral agents

UBC Department of Medicine Page 31 Annual Report 2007

• Complications of antiretroviral therapy, including lipodystrophy, dyslipidemias, cardiovascular disease, mitochondrial toxicity, peripheral neuropathy, hepatotoxicity, nephrotoxicity, osteopenia/osteoporosis, hypersensitivity reactions • Effect of treatment interruptions on long-term outcomes of HIV disease • Assessing and optimizing adherence to antiretroviral regimens and hepatitis C therapy • Pharmacokinetics of antiretroviral drugs, achieving optimal therapeutic drug levels, and drug interactions • Treatment and complications of hepatitis B and C co-infections • Prevention and treatment of opportunistic infections • Observational studies of HIV-related immune reconstitution syndromes

International Health

The Division is working in close collaboration with several countries to continue developing resources, training, services and research. These countries include Argentina, Mexico, Africa (Kenya, Uganda, Malawi) and China. There is active collaboration with Médecins Sans Frontières and the World Health Organization to develop antiretroviral guidelines for injection drug users in Eastern European countries and South East Asia, as well as their HIV Drug Resistance Network. We are also involved in a number of international cohort collaborations including the NA-ACCORD and ART Cohort Collaboration.

Students/Residents/Postdoctoral Research Fellows:

Student Name Program Type Dates Supervisor(s) Ainsworth, Liz Research Student-Epidemiology 2007 T. Kerr Barrios, Andrea Student Research Assistant Jun–Aug 2007 R. Hogg, J. Montaner Blades, Ryan Undergrad (biology) 2006-07 E. Wood, T. Kerr Burgess Susan Preceptorship (Vancouver) Jan-Mar 2007 J. Montaner DeBeck, Kora MSc Public Policy 2006-2007 J. Montaner, T. Kerr, E. Wood PhD Drug Policy 2007-present Fairbairn, Nadia Medical Student 2007 T. Kerr, E. Wood Fink, Valeria Preceptorship (Argentina) Jan-Feb 2007 J. Montaner Gill, Vikram MSc 2005-2007 R. Harrigan, M. Tyndall, T. Lampinen Harrison, Rebecca Student Research Assistant May-Aug 2007 R. Hogg, J. Montaner Hayden, Anna Student Research Assistant Jun-Dec 2007 J. Montaner Hoda, Zia Medical Student 2006-07 E. Wood, T. Kerr Ireland, Laurie Preceptorship (UBC) Jun 2007 J. Montaner Jahnke, Natalie Postdoctoral Research Fellow-Health Sept 2006- J. Montaner Professional present Lazar, Michelle Student Research Assistant May-Aug 2007 R. Hogg, J. Montaner Lima, Viviane PhD 2006-present J. Montaner, R. Hogg Lin, Ada Preceptorship (Hong Kong) Apr-Jun 2007 J. Montaner Lloyd-Smith, Elisa PhD-Epimiology, HIV/IDUs, SIS Sept 2005- R. Hogg, E. Wood, (UBC) present Sheps, T. Kerr, M. Tyndall

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Low, Andrew MSc 2005-2007 R. Harrigan, J. Montaner, B. Cherkasov Maas, Benjamin Research Assistant 2005-2006 T. Kerr, J. Montaner Marshall, Brandon MSc Epidemiology 2006-present T. Kerr, J. Shoveller McCarthy, Sheila Graduate Student-Epidemiology 2003-present D. Patrick, E. Wood, A. Jolly McKnight, Ian Medical Student 2006-2007 E. Wood, T. Kerr McLaren, Meaghan Preceptorship (Ottawa) Apr-Jun 2007 J. Montaner McLean, Mark Preceptorship (Vancouver) Sept-Dec 2007 J. Montaner Miller, Cari Postdoctoral Fellow 2006-2007 S. Strathdee, T. Kerr, E. Wood Milloy, M-J MSc Epidemiology 2006-present T. Kerr, E. Mathias Ng, Francisco Postdoctoral Research Fellow-Health 2005-Jun 2007 J. Montaner Professional Ochoa, Paula Postdoctoral Research Fellow-Health Jun 2007-present J. Montaner Professional Rachlis, Beth MSc-Epidemiology, Sept 2005-Oct R. Hogg, J. Montaner, HIV/migration/IDU (UBC) 2007 T. Kerr, E. Wood Reyes-Smith, Larina Preceptorship (UBC) Nov-Dec 2007 J. Montaner Richardson, Lindsey MSc Sociology 2007-2007 T. Kerr, E. Wood Rocha, Clara Postdoctoral Research Fellow-Health Dec 2005-Jun J. Montaner Professional 2007 Sadr, Aida Preceptorship (UBC) Sept-Nov 2007 J. Montaner Shannon, Kate PhD Epidemiology 2004-present M. Tyndall, T. Kerr Small, Will PhD Epidemiology 2005-present J. Shoveller, T. Kerr, E. Wood Stoltz, Jo-Anne Postdoctoral Fellow 2006-present E. Wood, T. Kerr, R. Hogg Wali, Ghassan Clinical Fellow (Saudi Arabia) Aug 2006-Jul J. Montaner, P. 2007 Phillips Watson, Emma Student Research Assistant Jun 2006-Dec J. Montaner, R. 2007 Harrigan Werb, Daniel Research Assistant Jun 2006-Nov T. Kerr, J. Montaner 2007 Wood, Alan Nursing 2007-present T. Kerr, Rodney Wood, Evan Preceptorship (Calgary) Mar-Apr 2007 J. Montaner Wynne, Elaine Preceptorship (Vancouver) May 2007 J. Montaner Al Barrak, Jasem Residency-Infectious Diseases and 2007 J. Montaner Al Fagih, Rashed HIV/AIDS Badawi, Maha Ko, Hinhin Nguyen, Van Paulus, Stephane Peters, Laurenna Rizkallah, Jacques Rodrigo, Judith Stephanovic, Aleksandra Waechter, Jason

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Awards & Distinctions

Full Name of Full Name of Winner Name Winner Title(s) Description* Award Awarding Body Julio S. G. Montaner MD; Professor of UBC Killam Prize UBC Killam Prize UBC Killam Research Prizes are awarded Medicine, Chair in for Senior Sciences annually to top campus researchers. Up to AIDS Research and Category ten prizes in the amount of $5,000 each Head of Division of are awarded to fulltime faculty members AIDS, UBC; Director in recognition of outstanding research and of the BC Centre for scholarly contributions of international Excellence in significance. HIV/AIDS; President- Elect, International AIDS Society Julio S. G. Montaner Research & Providence Health This honour recognizes a scientist in the Mission Award Care Research organization who demonstrates the Institute mission and values of Providence Health Care while conducting outstanding research. Julio S. G. Montaner Distinguished UBC Faculty of Special meritorious recognition Achievement Medicine Award for Overall Excellence Julio S. G. Montaner Science & BC Innovation These awards honour the pioneers and Technology Council visionaries who are advancing British Champion of the Columbia as a world-class centre for Year Award innovation. BC Innovation Council award (leadership in winners are widely renowned as leaders HIV/AIDS clinical in research, technology and innovation. work and research)

Julio S. G. Montaner Osler Lecture Vancouver Medical Each year the VMA executive recognize Association and choose a prominent physician to give the Osler Lecture. Thomas Kerr PHD; MSFHR Presidents Award University of British The award is given to a UBC faculty Scholar; Research for Public Columbia member who has most demonstrated Scientist, BC Centre Education Through outstanding service to the university and for Excellence in Media the community by sharing research HIV/AIDS; Assistant expertise via the news media. Professor, Dept. Of Medicine, UBC Thomas Kerr National Award for Canadian Institutes This award honours and supports teams Knowledge for Health Research or organizations that make an outstanding Translation contribution to the health of Canadians or to the health system through exemplary knowledge translation.

Evan Wood MD, PhD; Researcher, Canadian Medical Canadian Medical This is awarded annually to individuals BC Centre for Association Award Association who have made a leadership contribution Excellence in for Young Leaders to national or international public health HIV/AIDS; Clinical or medical issues. Assistant Professor, Dept. of Medicine, UBC

UBC Department of Medicine Page 34 Annual Report 2007

ALLERGY & IMMUNOLOGY

Dr. R. Robert Schellenberg Professor and Head

Faculty Members

Professor Schellenberg, Dr. Robert SPH Clinical Professor Wong, Dr. H. C. George VA Clinical Associate Professor Stark, Dr. Donald SPH Clinical Assistant Professor Kanani, Dr. Amin Vancouver Clinical Assistant Professor Kim, Dr. Seung VA

Divisional Overview

Our division is involved in providing clinical teaching in allergy and immunology at all levels. This includes major initiatives in patient education, CME programs for physicians, and elective rotations for residents and medical students. We are currently working to establish a training program in at UBC, a major commitment for a small division with limited resources. The need for an additional training program in our discipline in Western Canada was highlighted by the external review of our division in December ’06. The benefits to the country in addition to British Columbia were mentioned. Increased exposure of trainees should aid in recruitment to our subspecialty which, in a recent national survey of physicians in Canada, had one of the highest levels of professional satisfaction. Dr. Donald Stark chairs the Specialty Committee of Allergy and Clinical Immunology for the Royal College and is leading this initiative. The planned program would be a joint one with the Pediatric program in Allergy and Immunology at BC Children’s Hospital. Members from adult and pediatric divisions are supportive and preparation of the necessary applications are underway.

An additional major initiative is the development of a specialized clinic for Primary Immune Deficiency patients. Goals are to have a defined clinic where these patients can have specialized teaching and training for the initiation of home therapy with replacement immunoglobulin. Such a facility would enhance patient care while decreasing the requirement for hospital resources. Drs. Kanani, Stark and Schellenberg are actively pursuing this in collaboration with the outpatient nursing coordinator and the blood bank administrator at St. Paul’s Hospital. A number of patients have now been successfully trained for self administration of subcutaneous immunoglobulin

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(scIg) at home and this program is expanding. There remains a critical need for Ministry of Health support for this program which would have major benefits for patients and hospital resources.

Dr. Seung Kim is a community member of our division. Dr. Kim has an active practice in Burnaby and has been very obliging in taking residents into his clinic and providing excellent teaching in this outpatient setting. We are actively recruiting additional community members as the BC Society of Allergy and Immunology contains a highly interactive membership which partakes in regular educational retreats, the programs being organized by Dr. Kim and Dr. Ross Chang.

Teaching

All members of the Division are actively involved in teaching students, residents, community physicians and lay persons.

Dr. Schellenberg provides an introductory lecture to Medicine I students on the basic mechanisms of allergic inflammation as well as teaches in the Pathology 521 course. All members actively participate in case-based subspecialty teaching seminars for Med III / IV students and provide individual office-based teaching of students who have chosen an elective rotation in the subspecialty. In addition, each member teaches in the Clinical Skills block for Med I students and conducts Bedside teaching sessions with Med II students.

The month-long elective rotation for residents in Internal Medicine and it subspecialties has become increasingly popular in recent years. Members commit a half to a full day per week of their office practice for each resident and Dr. Schellenberg has one on one teaching sessions two half days each week with the resident, reviewing basic and clinical topics of relevance.

Major initiatives have been undertaken in community medical education to physicians, other health care professionals and to the lay public. CME programs organized by Dr. George Wong through the auspices of the UBC Community Programs are given in various communities in British Columbia and the Northwest Territories. These have received excellent evaluations and are highly appreciated by physicians in outlying areas. Each member contributes to these programs.

Dr. George Wong has developed specific expertise in evaluation of complementary and alternative medicine practices and has presented a number of interesting papers on these aspects at meetings in the USA and Canada, as well as to the BC Qualified Acupuncturists and Traditional Chinese Medicine Practitioners Association. He is a committee member of the Complimentary and Alternative Practices in Allergy Committee of the American Academy of Allergy, Asthma and Immunology (AAAAI) and involved in this organization’s adverse reaction to drug and biological committee as well as is a member of the BCMA committee on allied health and alternative therapies.

Dr. Amin Kanani is a member of the Jeffrey Modell Foundation of Canada, an organization that promotes awareness of primary immune deficiency with health care providers and the lay public. He has organized a local Immunology Journal Club that brings together pediatric and adult

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immunologists to foster interaction and share knowledge and the development of needed laboratory testing. He and Dr. Schellenberg have been involved in an initiative that led to adding the “Ten Warning Signs for Primary Immune Deficiency” to the pamphlet “Do Bugs Need Drugs”, a highly successful program in BC and Alberta developed by Dr. Mary Carson that reviews signs of infections and general considerations for health care providers (25,000 pamphlets distributed). This collaboration has been very fruitful and further aspects of joint teaching sessions are being discussed.

All members have been actively involved in providing teaching seminars in various communities in British Columbia. Examples include Grand Rounds presentations at Kelowna General, Surrey Memorial and Royal Jubilee Hospitals on topics of immune deficiency and management of difficult asthma.

Research and Clinical Practice Guidelines

The members at St. Paul’s hospital have a major interest in management of Primary Immune Deficiency and have initiated a number of research projects as well as interactions with the lay organizations, Canadian Immune Deficiency Patient Organization and the Jeffrey Modell Foundation. Dr. Amin Kanani is the principal investigator on a grant-in-aid (co-investigators Dr. Stark and Dr. Schellenberg) evaluating the quality of life and health outcome parameters of patients with primary immunodeficiency using two different dosing regimens of IVIG to determine optimal dosing requirements. Preliminary results suggest very interesting findings that may form the basis of modifications to present clinical recommendations (presented by Dr. Kanani at the AAAAI annual meeting in Feb ’07).

Dr. Stark is the principle investigator (Dr. Kanani and Schellenberg are co-investigators) in a study evaluating the subcutaneous administration of an IVIG product which would allow home- based therapy.

Dr. Kanani was a committee member evaluating subcutaneous vs. IV immunoglobulin therapy for Primary Immune Deficiency, evaluating the efficacy and cost effectiveness for the Canadian Agency for Drugs and Technologies in Health.

Dr. Schellenberg is a member of a Canadian Blood Services committee formulating evidence- based guidelines for the use of IVIG and scIG in patients with Primary Immune Deficiency.

Dr. Schellenberg was also involved in the formation of guidelines for the management of allergic rhinitis and continues involvement with a multidisciplinary group formulating guidelines on chronic rhinosinusitis.

Dr. Stark is involved with a national study sponsored by the AllerGen NCE evaluating “Anaphylaxis and Treatment Methods within the School System.”

Dr. Schellenberg is involved in a national study sponsored by AllerGen devising an internet-based peer group interactive program for adolescents with asthma and anaphylaxis.

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Dr. Wong is conducting studies assessing the use and potential harmful effects of herbal and Chinese medicines and regularly presents at local and international meetings.

Clinical Services

All members are actively involved in providing clinical consultative services in Allergy and Immunology to the community. Dr. Mandl continues to provide allergy clinics to a number of aboriginal communities in Northern BC. Dr. Stark provides outreach clinics in Prince George and Sechelt. He has been active with the hospitals in establishing protocols for the management of latex allergy in hospitals. Dr. Wong has had a specific interest in complimentary medicine practices and the potential harmful effects of specific treatments.

A major initiative at St. Paul’s Hospital to improve the care of patients with primary immunodeficiency is being led by Drs. Kanani, Stark and Schellenberg in conjunction with Debbie Laflamme (Supervisor of Outpatient Services) and Darryl Gouthro (Manager of the Blood Bank). This entails the establishment of an outpatient clinic and registry to provide service to these patients and initiate home subcutaneous or intravenous immunoglobulin therapy. The goal of this project is to have a provincial centre and resource for all patients with primary immune deficiency and link registries with others across Canada and globally.

National and International Initiatives

Members are very involved with the national programs for Allergy and Clinical Immunology.

Dr. Stark chairs the Subspecialty Committee for Clinical Immunology and Allergy of the Royal College of Physicians and Surgeons of Canada and is a Past-President of the Canadian Society of Allergy and Clinical Immunology.

Dr. Schellenberg is the Chair of the Examination Committee for Clinical Immunology subspecialty of the Royal College of Physicians and Surgeons of Canada. He is also a Past- President of the Canadian Society of Allergy and Clinical Immunology.

Dr. Kanani is a member of the Steering Committee of the Jeffrey Modell Canadian Immunodeficiency Network.

Dr. Schellenberg is a member of the Medical Advisory Committee of the Canadian Immune Deficiency Patient Organization.

Dr. Stark is a member of the Board of Directors for the Canadian Foundation for Allergy and Clinical Immunology, a charitable organization of which Dr. Stark was the founder.

All members are actively involved in local, national and international committees dealing with their areas of interest. Dr. Stark remains the Economics Chair from the section of Allergy and Clinical Immunology for the Society of Specialist Physicians and Surgeons of BC.

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Future Direction

The initiative to develop a Royal College accredited teaching program in our subspecialty and evaluate means of increasing exposure to medical students is being actively pursued. Due to our limited numbers and the expanding requests for elective rotations in our subspecialty, we plan to increase our membership by adding excellent clinical faculty from the community. A number already contribute significantly to our ongoing teaching programs that involve both pediatric and adult programs. The application proposal is presently being actively developed by Dr. Stark and Dr. John Dean with the support of all members of both the Dept. of Pediatrics and Dept. Medicine.

A major initiative of the division is the development of a Comprehensive Care Program for patients with Primary Immune Deficiency in British Columbia. We are working collaboratively with groups across the country to establish a registry of these patients for improved care and opportunities for multi-centred research initiatives. Locally we are working to have a specific outpatient clinic where management can be better coordinated, especially as we move to home immunoglobulin replacement therapy. We are the first adult centre to initiate this and are developing a business plan to the Ministry of Health to make this a provincial resource that would provide superior, standardized care at lower cost.

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CARDIOLOGY

Dr. Christopher E. Buller Professor & Head

Faculty Members

Professor & Head Buller, Dr. Christopher SPH/VA Professor Cairns, Dr. John VA Professor Kerr, Dr. Charles SPH Professor Mancini, Dr. G B John VA/SPH Professor1 Mayo, Dr. John VA Professor Rabkin, Dr. Simon VA Associate Professor (Honorary) Henning, Dr. Hartmut VA Associate Professor Humphries, Dr. Karin SPH Clinical Professor Carere, Dr. Ronald SPH Clinical Professor Fung, Dr. Anthony VA Clinical Professor Hamburger, Dr. Jaap VA/SPH Clinical Professor Huckell, Dr. Victor VA Clinical Professor Kiess, Dr. Marla SPH Clinical Professor Penn, Dr. Ian VA Clinical Professor Ricci, Dr. Donald VA Clinical Professor Webb, Dr. John SPH Clinical Professor Yeung-Lai-Wah, Dr. John SPH Clinical Associate Professor Gin, Dr. Kenneth VA Clinical Associate Professor Ignaszewski, Dr. Andrew SPH Clinical Associate Professor Jue, Dr. John VA Clinical Associate Professor Thompson, Dr. Christopher SPH Clinical Assistant Professor Aymong, Dr. Eve SPH Clinical Assistant Professor Chan, Dr. Sammy SPH Clinical Assistant Professor Heilbron, Dr. Brett SPH Clinical Assistant Professor Isserow, Dr. Saul VA Clinical Assistant Professor Lee, Dr. Pui-Kee VA Clinical Assistant Professor Moss, Dr. Robert SPH Clinical Assistant Professor Nair, Dr. Parvathy VA Clinical Assistant Professor Rabinowitz, Dr. Alan SPH

1 Joint tenure appointment 50:50 with Department of Radiology UBC Department of Medicine Page 41 Annual Report 2007

Clinical Assistant Professor Ramanathan, Dr. Krishnan SPH/VA Clinical Assistant Professor Saw, Dr. Jacqueline VA Clinical Assistant Professor Straatman, Dr. Lynn SPH Clinical Assistant Professor Wong, Dr. Graham VA Clinical Instructor Munt, Dr. Bradley SPH Clinical Instructor Tung, Dr. Stanley SPH Clinical Instructor Virani, Dr. Sean VA/SPH Adjunct Professor Lear, Dr. Scott SPH Professor (Emeritus) Boone, Dr. John SPH Professor (Emeritus) Kavanagh-Gray, Dr. Doris SPH Professor (Emeritus) Mizgala, Dr. Henry Vancouver Professor (Emeritus) Peretz, Dr. Dwight West Vancouver Clinical Professor (Emeritus) Bernstein, Dr. Victoria VA Clinical Professor (Emeritus)2 Dodek, Dr. Arthur SPH Clinical Associate Professor (Emeritus) MacDonald, Dr. Ian SPH Clinical Professor (Emeritus) Shaw, Dr. Melville Vancouver Clinical Professor (Emeritus) Walters, Dr. Max

Associate Members of UBC Division of Cardiology appointed in 2007:

Clinical Assistant Professor Aminbakhsh, Dr. Amin Royal Columbian Clinical Assistant Professor Ashton, Dr. Tom Penticton Regional Clinical Assistant Professor Fretz, Dr. Eric Royal Jubilee

Divisional Overview

The UBC Division of Cardiology consists of 36 active faculty (including 7 full-time faculty, and 29 clinical faculty distributed over two large tertiary programs at St. Paul’s Hospital and Vancouver Acute (including UBC site). This number includes two new recruits to the Division during 2007; Dr. James Nasmith and Dr. Sean Virani. Eleven additional members enjoy emeritus, honorary or adjunct status. The Division has also appointed 3 Associate Members to the Division during 2007, driven in part by the Medical School expansion. In 2007, Dr. Christopher Buller entered his fourth year as Head, UBC Division of Cardiology and Sauder Family Heart & Stroke Foundation Chair in Cardiology, as well as Head, Division of Cardiology, Vancouver Acute. Dr. Andy Ignaszewski (Clinical Associate Professor) enters his second year as Head, Division of Cardiology for St. Paul’s Hospital.

The UBC Division of Cardiology provides a comprehensive range of tertiary and quaternary cardiology sub-specialty services and programs, including ambulatory and inpatient consultative cardiology, specialized clinics including heart function, cardiac intensive care, electrodiagnostics, cardiac ultrasound, interventional cardiology, electrophysiology, nuclear cardiology, adult congenital heart disease, cardiac transplantation and ventricular assist, atherosclerosis risk reduction and cardiac rehabilitation, and advanced cardiac imaging.

2 Appointment not yet confirmed. UBC Department of Medicine Page 42 Annual Report 2007

Teaching

Undergraduate:

Whether students choose to be general physicians or specialists, a foundation in the cardiovascular sciences and clinical examination is an essential part of their skill set. To ensure students are prepared for their future clinical practice, the Division has taken an active and integral role I the undergraduate curriculum. In the past year, the Division has contributed over 170 hours in bedside clinical skills teaching, seminars and problem-based tutoring. The Division has also recognized the students by accommodating over 35 elective students on the inpatients services, such as CCU, and in cardiologists’ offices. Faculty continue to play an important part in the development of the curricular content as well as recruiting volunteer patients for clinical skills teaching. The UBC medical school now has over 250 students per year, and the Division is committed to its leadership role in undergraduate teaching using evidence-based teaching methods and assessment tools, as well as the incorporation of newer technologies, such as clinical simulation, to impart cardiovascular knowledge and skills. The UBC medical school received full accreditation in the past year, and in the face of rapid expansion of the student body and movement other geographical sites, the Division has continued to support the undergraduate curriculum in cardiology and clinical skills.

Postgraduate:

The UBC Postgraduate Program in Cardiology (Ken Gin, Director, Krishnan Ramanathan Associate Director) now comprises 14 residents and will further increase to 16 residents on July 1, 2008. Currently, there are 7 Ministry funded residents and 6 externally funded residents. One additional resident is funded through a partnership with the Healthy Heart Society.

Academic aspects of the program continue to strengthen with an extensive weekly curriculum of structured bedside teaching, internal and guest faculty lectures, resident-led presentations, and journal club reviews of contemporary literature, compromising 6—10 hours of structured teaching weekly. Exposure to cardiac radiology has been enhanced, with the cross appointment of Dr. John Mayo from Radiology. Research mentoring has been enhanced by the appointment of three hospital-based postgraduate research directors, Drs. John Jue (VGH), Krish Ramanathan (SPH/VGH) and Sammy Chan (SPH). The program has raised over $20,000 to support resident research. At the 2007 Canadian Cardiovascular Society Congress we witnessed 9 presentations by the Cardiology residents.

The core training program was reviewed by the Royal College in February 2007 and received full accreditation. The many strengths of the program were noted.

All UBC candidates who took the Royal College examination in Cardiology were successful. Moreover, all of our core program graduates from 2006 have secured positions for subspecialty training or staff positions.

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The subspecialty programs continue to include Interventional Cardiology,Electrophysiology, Echocardiography and Heart Function/Transplant and advanced cardiac imaging.

Continuing Medical Education

Internal Rounds

Across sites, the Division of Cardiology presents a rich curriculum of regular lectures and rounds. Cardiology Grand Rounds is presented weekly at each hospital. In addition, a variety of city-wide and hospital-based rounds are held regularly as follows:

• Interventional Cardiology (weekly, both sites) • Combined Cardiology/Cardiac Surgery (weekly, both sites) • M&M (weekly at SPH, monthly at VH) • Echocardiography (monthly, VGH) • Grand Cardiology Rounds (weekly, VGH and SPH) • Resident Noon rounds (weekly, SPH) • Research Rounds (bi-weekly, SPH) • Journal Club (monthly, city-wide)

Distinguished Speakers in Cardiovascular Medicine

2007 saw the fourth year of the Distinguished Speakers in Cardiovascular Medicine series held monthly during the academic year. Hosted jointly with the UBC Division of Cardiac Surgery, this program is directed by Drs. Buller and Andrew Ignaszewski and brings prominent cardiovascular academics to Vancouver for 1 or 2 days of focused activity and interaction including research seminars, resident teaching, and the Distinguished Speaker Lecture itself. A broad range of tertiary and community cardiovascular specialists and researchers attend these lectures. They afford an important opportunity for basic scientists, clinical and academic physicians, cardiac surgeons, as well as faculty and staff from pharmacy and other allied health disciplines to meet and interact.

A key goal of this guest lecture series is to maintain complete academic independence with respect to the choice of speakers and topics. Funding it, however, requires industry support. To resolve this paradox, the cardiac pharmaceutical and device industry was approached at large by the Divisional leadership to provide shared funding without any input regarding content. In 2007, 11 industry partners supported Distinguished Speakers through this arms length funding arrangement and we were fortunate in attracting 7 truly distinguished speakers during the period:

• Dr. Arya M. Sharma McMaster University • Dr. Ruth McPherson, Ottawa Heart Institute • Dr. Subodh Verma, St. Michael’s Hospital, Toronto • Dr. Lars Lindholm, University Hospital, Sweden • Dr. Jacques Genest, McGill University Health Center • Dr. Rob Beanlands, Ottawa Heart Institute • Dr. Eva Lonn, McMaster University

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Synchronization of the time slot for hospital-based cardiology grand rounds was undertaken this year in order to improve attendance at Distinguished Speaker rounds. This approach has been successful with excellent cross-site attendance noted.

Course & Convention Leadership / Selected Lectures and Presentations

Dr. Christopher Buller: • Faculty Member – Emerging Technologies Symposium “Convergent Therapeutics for Vascular Disease: Advances in Atherosclerosis – Provocative Roundtable Discussion” Panel Member. 5th Annual Emerging Technologies Symposium, Science Innovation Synergy (SIS) 2007, Seattle. August 1, 2007 • Montreal Live Course, Montreal Heart Institute, University of Montreal, Course Co-Director 14-16 June, 2007 • Invited Presentation: “PCI for Persistent Occlusion after MI: The Occluded Artery Trial”. Convergent Therapeutics for Vascular Diseases Session, 5th Annual Emerging Technologies Symposium, Science Innovation Synergy (SIS) 2007, Seattle. August 1, 2007

Dr. Ronald Carere: • The 9 th Annual Excellence in Interventional Cardiology (December 2007) - Course Co – Director with Dr Eric Cohen, University of Toronto. This 3-day course for Interventional Cardiologists is attended by Interventional Cardiologists from across Canada. The curriculum emphasizes novel topics relevant to interventional cardiology including advances in evidence- based practice and public policy challenges.

Dr. Karin Humphries: • National Forum for Young Investigators in Circulatory and Respiratory Health - Steering Committee Member 2004-2006

Dr. John Jue: • Canadian Society of Echocardiography Meeting – Vancouver, April 2008: Local planner Member of Planning Committee

Dr. Simon Rabkin: • 3rd Annual “Hot Topics in Cardiology” CME Event, April 2007

Dr. G.B. John Mancini: • Invited Presentation: "Reassessment of the role of PCI in the treatment of patients with chronic stable angina", Regina Cardiac Society, Regina, Saskatchewan, Canada, April 26, 2007 • Invited Presentation: "The case for medical therapy as the default choice." EURO PCR07. Barcelona, Spain. May 2007 • Invited Presentation: "PCI with Stable Atherosclerosis: COURAGE Trial and Beyond" at the SIS Emerging Technologies Symposium, Swedish Medical Center, Seattle, WA, August 1, 2007.

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• Invited Lecture: “The COURAGE Trial: The Role of PCI and Modern Medical Therapy for Chronic Stable Angina”, The Harold and Kitty Schildkraut Memorial Lecture at Aurora St. Luke’s Medical Center, Milwaukee, WI, October 11, 2007.

• Invited Speaker: “Simultaneous Improvement of Pulmonary & CV Outcomes in Patients with COPD: Where There is Smoke, There is Fire!”, St. Michael’s Hospital Cardiology Research Rounds, Toronto, ON, November 12, 2007 • Invited Speaker: “Evolving Implications of the COURAGE Trial”, St. Michael’s Hospital Cardiology Grand Rounds; Toronto, ON, November 12, 2007 • Invited Speaker: “Evolving Implications of the COURAGE Trial” Sunnybrook Cardiology Research Rounds, Sunnybrook Hospital, Toronto, ON, November 13, 2007 • Invited Speaker: “Simultaneous Improvement of Pulmonary & CV Outcomes in Patients with COPD: Where There is Smoke, There is Fire!”, London Health Sciences, London ON, November 13, 2007 • Invited Presentation: “From Clinical Trials to Clinical Practice-Translating the Latest Evidence in Lipid Management into Practice (Evolving Implications of the COURAGE Trial)”, London Lipid Club, London ON, November 13, 2007 • Invited Speaker: “Evolving Implications of the COURAGE Trial”, Endocrinology Grand Rounds, London Health Sciences Centre, London ON, November 14, 2007. • Invited Speaker: “Novel Opportunities to Alter Morbidity and Mortality of COPD”, 2007 Annual J. Allyn Taylor International Prize in Medicine Symposium, Robarts Research Instititute, London ON, November 14, 2007

Dr. John Webb: • Live case transmission director: TCT. • Committees: Health Canada, Scientific advisory committee on therapeutic devices. ACC Cath and CV Intervention. • Leiden, Netherlands, speaker, Jan • New Westminster, BC, Royal Columbian Hospital, speaker, Feb • Vancouver, St. Paul’s Hospital ResearchFest, speaker, Feb • Rome, Italy, Joint Interventional Meeting, speaker, Feb 15-17 • Toronto, Toronto General Hospital, proctor, May • Banff, WECREEP Canadian cardiology fellows conference, Mar • Washington DC,Cardiovascular Revascularization Therapy, speaker, Mar 7-8 • Washington DC, i3 audio CD interview • Lake Louise, Alta, ACC regional meeting, speaker, Mar • New Orleans, American College of Cardiology, Mar 25 • New Orleans, ACC Cardiosource audio CD interview, Mar • Dallas, proctor, Mar and May • Toronto General Hospital, proctor Jan and Apr 07 • St. Petersburg, Valve meeting, speaker, Mar • Padua, Italy, live video speaker, May • Quebec City, Laval University, proctor, May • Barcelona, EuroPCR, speaker, May • Orlando, SCAI, speaker/chair, May • Boston, ACC Valve meeting, speaker, June 7-9

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• Aarhus, Denmark, University Hospital, proctor, June • Frankfurt, West Germany Heart Center, proctor, June • Vienna, Austria, University Hospital, proctor, June • Geneva, Swiss Heart Association, course director, Jun 07 • Frankfurt, Cardioskills course, speaker, June • Frankfurt, Cardioskills course, cours director, July • Vancouver, International Congress of Cardiology, speaker, July • Las Vegas, PICS, live case demonstrator, speaker, July 22-25 • Christchurch, New Zealand, ANZET, speaker, Aug 8-9 • Frankfurt, Cardioskills course Aug x2 07 • Aarhus, Denmark, grand rounds, proctor, Aug 07 • Leipzig, Germany proctor Aug 07 • London, King’s College Hospital, honorary consultant Sept – Dec 07 • Harrisberg, PA, C3 meeting, live case demonstrator, Sep 07 • Chicago, America Association of Thoracic Surgery, Steering committee, speaker, Sept • Los Angeles, Cedars-Sinai, visiting speaker, Oct 07 • Rouen, Valve course, speaker, Oct 07 • Orlando, American Heart Association, speaker Nov 07 • Orlando, ACCEL, audiotape journal interview • Orlando, JACC, videotape journal interview • Tel Aviv, Innovations in Cardiovascular Interventions, speaker, Dec 07 • Denver, University of Colorado, visiting professor, Oct 07 • Frankfurt, Cardioskills, course director, Nov 07 • Athens, Onassis Heart Surgery Center, Nov 07 • Tel Aviv, Israel, ICI meeting Dec 07 • London, Royal Brompton, Dec 07 • Los Angeles, Cedars Sinai, Nov and Dec 07

Research

Dr. Victoria Bernstein continues to be actively involved in research. Ongoing studies include: STICH; Magnesium study - Assessment of i/v magnesium for decrease in atrial arrhythmias after heart surgery; BEAUTIFUL study - Ivabradine vs.. placebo CAD with LV dysfunction; ONTARGET - Telmisartan/Ramipril or combination in high risk cardiac patients; AF-CHF- Rate control vs.. rhythm control in patients with LV dysfunction and paroxysmal AF; AUDITOR - Rimonabant in the regression of arteriosclerosis disease. Studies completed include: SIMPATICO- Immune modulation in patients with severe intermittent claudication; ACCLAIM - Immune modulation in patients with class III & IV CHF; IMAGINE - Use of Quinapril in early post operative patients undergoing CABG; RUTH - Assessment of Raloxifene in women with ASHD; HOPE TOO; AMADEUS. Dr. Bernstein has served on numerous adjudication committees. These include SAVE; CARE; HOPE; PRAISE; COPERNICUS; HOPE TOO; ACCLAIM and IMAGINE. She is on the advisory board to Servier and Sanofi Aventis.

Dr. Christopher Buller is active in numerous clinical trials and in outcomes research. His primary research focus in recent years has been through his executive involvement in the NIH/NHLBI funded Occluded Artery Trial testing the late open artery hypothesis for patients

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with recent myocardial infarction. Numerous secondary analyses and publications are now in preparation. As a member of the OAT team, funding for long term follow up of patients enrolled in OAT and TOSCA-2 has recently been awarded by NIH/NHLBI. Dr. Buller remains the Canadian PI for the NIH/NHLBI FREEDOM trial which has now enrolled more than 250 patients across 14 Canadian centres. In 2007 Dr. Buller was appointed for a three-year term to the American College of Cardiology/American Heart Association Guidelines Task Force, which oversees the development and revision of all guidelines arising from these organizations. He was also appointed as a Member of the Institute for Clinic Evaluative Studies Committee on MI Quality Indicators (ICES) in 2007.

Dr. John Cairns During the first half of 2007, Dr. Cairns continued to lead the efforts of colleagues in Vancouver Hospital, Providence, C&W and BCCA to obtain funding from CIHR/CFI for the creation of the Pacific Clinical and Translational Research Consortium. A large and ambitious application was prepared securing the cooperation of the Research Institutes of our 4 major teaching hospitals and of 5 Technology Platforms previously funded by MSFHR. Unfortunately, the application was turned down by CIHR/CFI, as were all the multicentre regional applications from centres in Calgary, Saskatoon, Toronto, Montreal and Halifax. Dr. Cairns chairs and is a member of a number of DSMBs of several large clinical cardiovascular trials, review regularly for several journals and also chairs the Division of Cardiology research award committee.

Dr. Ron Carere is an active participant in research activities related to the Transcatheter valve program in collaboration with Dr's Webb et al (Percutaneous and Transapical Heart Valves). He continues to pursue BC Cardiac Registry research activities with Dr Humphries and with investigators Dr Fretz and Hilton at the Victoria Heart Institute.

Dr. Sammy Chan is active in clinical trials and mechanistic research. His area of interest is preventive cardiology, endothelial function and endothelial progenitor cells. He is the St. Paul's Hospital site investigator for the CRESCENDO study investigating the potential role of Rimanobant in reducing adverse cardiovascular outcomes.

Dr. Karin Humphries’ areas of interest include sex/gender differences in CVD presentation, treatment and outcomes; health services research focused on secondary prevention; population- based rates of treatment, including PCI, CABG, and pharmacological therapy; and atrial fibrillation. Dr. Humphries has led B.C.'s team of contributors to the Canadian Cardiovascular Outcomes Research Team (CCORT) project and GENESIS - Gender and Sex Differences in Cardiovascular Disease - an Inter-disciplinary Capacity Enhancement Team funded by CIHR. A growing area of interest for Karin is investigator-driven randomized controlled trials. With her advanced theoretical and extensive practical knowledge, she supports and informs many such initiatives within the Division. As Principal Investigator, Dr. Humphries presently holds a New Investigator Award from the Canadian Institutes of health as well as funding from the Heart and Stroke Foundation and CIHR

Dr. Charles Kerr is a clinical electrophysiologist and carries out an active research program in cardiac arrhythmia management. His main area of interest has been atrial fibrillation (AF). He has directed the Canadian Registry of Atrial Fibrillation since 1990. CARAF I has followed 1100

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patients from their initial diagnosis of AF over 10 years, providing insight into progression of disease and clinical and laboratory outcomes. CARAF II has followed a more recent cohort to more carefully evaluate medical therapy provided by community physicians. He is also involved in drug trials of new antiarrhythmic and antithrombotic agents, as well as research trials of pacemakers and defibrillators. A publication in October , 2007 used the CARAF database to evaluate the use of statin drugs on development of recurrent AF after cardioversion (AmHeart J). Research funding awarded in 2007: Canadian Registry of Atrial Fibrillation. St. Jude Medical ($30,000) and Canadian Registry of Atrial Fibrillation. SanofiAventis ($83,000)

Dr. G. B. John Mancini has been active in clinical trials through his Cardiovascular Imaging Research Core Laboratory (CIRCL) which provides measurements of endothelial dysfunction (brachial artery ultrasound), carotid ultrasound, quantitative coronary intravascular ultrasound and quantitative coronary angiography (QCA). In addition, Dr. Mancini has expanded his research interests to include both clinical and molecular projects attempting to unravel the interplay between pulmonary diseases and cardiovascular events. Clinical projects assessing the impact of Chronic Positive Airway Pressure on carotid atherosclerosis and endothelial dysfunction in patients with Obstructive Sleep Apnea are underway. The European Respiratory Society asked for a presentation of the clinical implications of work linking improved outcomes in COPD patients to use of statins, ACE inhibitors and ARB’s at a specially convened conference in Rome, Italy in the fall. The ACROSS-Cypher® trial assessing the efficacy of sirolimus eluting stents in chronic total occlusions was completed in 2007. The North American COURAGE trial was presented as a late-breaking trial at the ACC in the spring and simultaneously published in the NEJM. M-CHAT carotid ultrasound study, under the stewardship of Dr. Scott Lear, was also completed and a follow-up grant from the CIHR has been awarded. IVUS analyses for the Biomarker/Transplantation project under the direction of Dr. Bruce McManus are on-going. CIRCL is also supporting Dr. Karen Humphries’ study of women with normal coronary angiograms.

Dr. Parvathy Nair was recruited from Toronto to the Division in February 2006. Her research is in the area of medical education, specifically in the areas of assessment and the use of simulation technology in the medical curriculum. She is presently the principle investigator for a randomized trial looking at the application of simulation technology on the cardiology clinical skills of undergraduate students. She has published in the area of assessment of echocardiography skills in cardiology trainees and has written grants for further projects in this novel research arena. She is also involved in echocardiography research, particularly in the use of stress echocardiography in the assessment of valvular heart disease.

Dr. Simon Rabkin’s research focuses on two aspects: molecular mechanisms of cardiac disease and clinical risk factors for atherosclerotic disease. His clinical research is currently on biomarkers - inflammatory indicators of disease in high risk patients.

Dr. Donald Ricci was appointed local PI for FREEDOM (CABG vs. PCI with DES in diabetics) and TRITON (new anti-platelet drug) in 2007.

Dr. Sean Virani’s research focuses interests include cardiac transplantation, acute decompensated heart failure (ADHF) and the cardio-renal axis in heart failure. He is principal

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investigator for the ASCEND-HF Trial which is examining the role of Nesiritide in ADHF and the BALANCE Trial which addresses vasopressin antagonism in heart failure patients with hyponatremia. Additionally, he is the lead North American Investigator for CONFIRM - a trial designed to assess the efficacy of a novel pacing algorithm in patients with heart failure. He is also a sub-investigator on a number of surgical heart failure trials through his collaboration with the transplant program at St. Paul's Hospital.

Dr. John Webb is director of interventional cardiology research at St. Paul’s hospital. St. Paul's Hospital has become internationally known for transcatheter valve intervention. The year of 2007 saw published or in press 13 valve related journal articles, 6 book chapters and invited presentations in 14 countries and several Audio interviews: (ACCEL x2, JACC Imaging, Cardiosource).

Dr. Graham C. Wong received two new operating grants from the VGH Division of Cardiology Research Fund in June 2007. The first grant was to fund a two-year collaborative initiative with the Division of Respirology examining the effect of CPAP therapy on LV function amongst patients with mild to moderate sleep apnea. The second grant was in support of a prospective cardiac CT angiography (CCTA) registry for Vancouver General Hospital. The registry was designed to mesh with current angiography databases including the BC Cardiac Registries. It is hoped that the CCTA registry could be expanded beyond VGH to include other hospitals in the Vancouver Coastal Health Region and the remainder of the province. Ongoing work continues on assessing the quality of reperfusion therapy in VGH and the rest of the hospitals in Vancouver Coastal Health Region as part of the VCH STEMI Initiative

VGH Division of Cardiology Research Awards – In 2006, the VGH Division of Cardiology in conjunction with the VGH and UBC Hospital Foundation established a semi-annual award competition targeting pilot projects led by VGH Division members. Applications are received January 1st, and July 1st and are reviewed by the Research Review Committee comprising Drs. John Cairns, John Mancini and Donald Ricci. During 2007 3 awards were assigned, bringing the total number of awards to 7 since the competition began.

Administration

Dr. Christopher Buller: • Head UBC Division of Cardiology • Head Division of Cardiology, VGH • Medical Director, Cardiology, Cardiac Science Program, VA • Member Provincial Advisory Committee on Cardiac Health • Council Member, Canadian Cardiovascular Society

Dr. Andrew Ignaszewski: • Head Division of Cardiology, SPH • Medical Director Healthy Heart and Heart Function Programs, SPH • Member Provincial Advisory Committee on Cardiac Health

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Dr. Ron Carere: • Physician Director, Heart Center, St Paul's Hospital • Clinical Director Cardiac Sciences Program, Vancouver Coastal Health • Chair Medical Advisory Committee, Providence Health Care • Co- Chair Health Authority Medical Advisory Committee, Vancouver Coastal Health • Member Provincial Advisory Committee on Cardiac Health

Clinical Sub-Program Leadership

• Acute Coronary Care o Krishnan Ramanathan* Graham Wong** • Adult Congenital Heart Disease o Marla Kiess* • Advanced Cardiac Imaging o John Mayo** • Arrhythmia Management o Charles Kerr* / Charles Kerr** • Cardiac Electrodiagnostics o Marla Kiess* John Jue** • Cardiac Ultrasound o Christopher Thompson* John Jue** • VGH & UBC Cardiovascular Clinic o Saul Isserow** • Healthy Heart Program (risk reduction and rehabilitation) o Andrew Ignaszewski* Saul Isserow** • Heart Function and Cardiac Transplantation o Andrew Ignaszewski* Sean Virani** • Interventional Cardiology & Cardiac Catheterization o John Webb* Anthony Fung**

* SPH Director **VGH Director

Clinical Sub-Program Reports:

Coronary Care Unit, Vancouver General Hospital (Dr. Graham Wong)

The 14-bed CCU at Vancouver General Hospital continues to provide tertiary level cardiac care to in-patients at VGH, the Vancouver Coastal Health Region and the remainder of the province. The CCU retains the capacity for full hemodynamic and ventilatory support for critically ill cardiac patients, and supports the activities of comprehensive percutaneous coronary intervention and cardiac surgical programs. New initiatives involving the CCU in 2007 have included the new AICD implant program at VGH that was developed in conjunction with Dr. Stanley Tung. Moreover, the recruitment of Dr. Sean Virani has allowed the development of an advanced heart failure program, which will likely involve bed and nursing resources from both the CCU and the new cardiac ward. Finally, the CCU at VGH will be an integral part of the new Vancouver Coastal Heath STEMI Prehospital Initiative, which will be operational in Spring 2008. This

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Regional Initiative, led by the two CCU Directors at VGH and SPH, will emphasize timely prehospital diagnosis and in-field triage of suspected STEMI patients to the two PCI capable hospitals in the region as part of a larger strategy to improve the access to and speed of primary angioplasty.

The CCU underwent a significant operational change in 2007 with the opening of the new 26 bed cardiac ward on Centennial Pavilion and the ceding of CCU2 to the new Medical Assessment Unit (MAU). It is anticipated that the increased inpatient capacity with the new ward will allow for greater flexibility for inpatient admissions and will ultimately improve access of critically ill cardiac patients from the rest of the region and the province. The CCU at VGH continues to be one of the highest rated teaching rotations in the Postgraduate training program in Internal Medicine at UBC, and continues to offer training to residents and fellows in Internal Medicine, Emergency Medicine, Neurology and Anesthesia. It should be noted that many of the CCU attending physicians have won major teaching awards. The CCU has continued to increase research output, with participation in many multicenter clinical trials in acute coronary syndromes, secondary prevention in chronic ischemic heart disease and acute heart failure.

Advanced Cardiac Imaging, Vancouver General Hospital (Dr. John Mayo)

The Advanced Cardiac Imaging program is poised to purchase an Advanced Cardiac CT scanner in 2008 which will be sited in the former stress laboratory space on the ground floor of the Jim Pattison Pavilion, at VGH immediately adjacent to the Cardiac Catheterization Laboratory. Cardiac CT rounds are held every second Wednesday with continued good attendance. Cardiology interventional fellows attend cardiac CT read out on a weekly basis and participate in research projects. Dr. David Wood's project "The role of multislice computed tomography in the assessment of transcatheter aortic valve replacement" won 4 prizes in resident awards competitions in 2007. Dr Percy Johki amassed sufficient experience in cardiac CT in the past year to successfully apply for level 2 recognition by the Society for Cardiolvascular CT. We have scanned over 800 patients in the last 2.5 years, with nearly 300 in the last 10 months on the new dual source CT scanner. We expect increasing clinical volumes and increased research with the installation of the new scanner.

Heart Rhythm Management (HRM) (Dr. Charles Kerr)

This is a comprehensive program that spans St. Paul's and Vancouver General Hospitals. The electrophysiology laboratory is at St. Paul's Hospital where all types of diagnostic and interventional EP procedures are performed, including complex mapping for atrial fibrillation, ventricular tachycardia and arrhythmias in patients with congenital heart disease. Implantation of ICDs has been commenced at Vancouver General Hospital and a regular arrhythmia clinic and specialized resident teaching have been implemented at VGH. Currently there are 3 extremely busy electrophysiologists (Charles Kerr, John Yeung, Stanley Tung), with the need for further recruitment of 2 - 3 more physicians. There is an active HRM training program that provides excellent teaching to Cardiology residents and EP Fellows. Currently there are 3 EP Fellows. Dr. Anzhen Qi continues to be an active researcher as a research associate in the program. There research program includes longitudinal follow-up of patients with atrial fibrillation (Canadian

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Registry of Atrial Fibrillation), epidemiology and outcomes in patients with medical devices, new antiarrhythmic and antithrombotic drugs, and innovative pacing technologies.

Heart Failure Program, Vancouver General Hospital (Dr. Sean Virani)

Dr. Virani was recruited to VGH in the spring of 2007 with the specific intent to develop a multidisciplinary heart failure program. A former cardiology trainee from UBC, Dr. Virani completed his heart failure and transplant fellowship at Stanford University before moving back to Vancouver in 2007. He continues to pursue a Master's degree in Public Health at Columbia University with a specific focus on healthcare management and public policy. Since his arrival, he has worked to develop the human resources and physical plant infrastructure, in addition to processes and care pathways paramount to the successful launch of a Heart Failure Clinic. With the support of the Division, private donors and the VGH and UBC Hospital Foundation, the heart failure clinic is slated to open in September 2008.

Special Honors and Awards 2007

Dr. John Cairns • Distinguished Achievement Award for Outstanding Contributions by a Senior Faculty Member (Lifetime Achievement), UBC Faculty of Medicine • Distinguished Service Award (Research and Service) Canadian Society for Clinical Investigation • Ronald Christie Award (Lifetime Achievement), Canadian Association of Professors of Medicine Dr. Ken Gin • Bobby Miller Award for Excellence in Teaching, Medical, Dental & Allied Staff, VA Dr. Victor Huckell • Career Award for Excellence in Clinical Teaching (Education), UBC Faculty of Medicine Dr. Karin Humphries • CIHR New Investigator Award (2006-2011) Dr. Charles Kerr • President-elect. Canadian Cardiovascular Society • Chair, Provincial Advisory Panel on Cardiac Health Dr. Donald Ricci • Invited speaker to Cardiovascular Symposium in Athens, Greece. • Consultant to Medtronic valve program. • Issuance of Canadian and U.S. Patents on stent design. Dr. Sean Virani • Panelist and invited presentation on heart failure, anemia and renal insufficiency: American College of Cardiology (Orlando, Florida – Nov 2007) Dr. John Webb • PHC Department of Medicine Faculty Research Award • Committees: Health Canada, Scientific advisory committee on therapeutic devices. ACC Cath and CV Intervention.

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COMMUNITY INTERNAL MEDICINE

Dr. Barry Kassen Clinical Professor and Head

Faculty Members

Clinical Professor & Acting Head Kassen, Dr. Barry SPH Clinical Professor Mitenko, Dr. Paul Nanaimo Clinical Associate Professor Sullivan, Dr. Stephen Victoria Clinical Assistant Professor Ayotte, Dr. Brian Shuswap Lake Clinical Assistant Professor Baillie, Dr. Hector Nanaimo Clinical Assistant Professor Bashir, Dr. Khalid Prince George Clinical Assistant Professor Gill, Dr. Shavinder Abbotsford Clinical Assistant Professor Iqbal, Dr. Zafar Prince George Clinical Assistant Professor Keshmiri, Dr. Mehdi Abbotsford Clinical Assistant Professor McDonald, Dr. David Victoria Clinical Assistant Professor McKee, Dr. Scott Salmon Arm Clinical Assistant Professor MacRitchie, Dr. Donald Prince George Clinical Assistant Professor Main, Dr. Christopher Victoria Clinical Assistant Professor Matossian, Dr. Sebouh New Westminster Clinical Assistant Professor Maung, Dr. Tun Abbotsford Clinical Assistant Professor Min, Dr. Simon Abbotsford Clinical Assistant Professor Richmond, Dr. Allister Chilliwack Clinical Assistant Professor Sherk, Dr. Peter Victoria Clinical Assistant Professor Sutcliff, Dr. Steven Vancouver Clinical Assistant Professor Taylor, Dr. Susan Vancouver Clinical Assistant Professor Wadge, Dr. Sara Sechelt Clinical Assistant Professor Williams, Dr. Dave Abbotsford Clinical Assistant Professor Wojtowska, Dr. Ewa Vancouver Clinical Assistant Professor Yang, Dr. Tung Chuo Vancouver Clinical Instructor Auersperg, Dr. Edward Maple Ridge Clinical Instructor Broder, Dr. Sarah Penticton Clinical Instructor Caswell, Dr. Sherri Richmond Clinical Instructor Cummins, Dr. Nora Vancouver Clinical Instructor Dyck, Dr. Chadwyn Penticton UBC Department of Medicine Page 55 Annual Report 2007

Clinical Instructor Ervin, Dr. Francis (Frank) Maple Ridge Clinical Instructor Fam, Dr. Ezz Chilliwack Clinical Instructor Kang, Dr. Anna Burnaby Clinical Instructor Kenyon, Dr. Michael Nanaimo Clinical Instructor Kincade, Dr. David Penticton Clinical Instructor Lai, Dr. Kevin Nanaimo Clinical Instructor McLeod, Dr. Kevin Vancouver Clinical Instructor Qureshi, Dr. Tariq M. Abbotsford Clinical Instructor Skinnider, Dr. Doug Victoria Clinical Instructor Son, Dr. Wai Kong Chilliwack Clinical Instructor Sunderwood, Dr. Jennifer Campbell River Clinical Instructor Walker, Dr. Shannon Penticton Clinical Instructor Winkler, Dr. Lawrence Nanaimo Clinical Instructor Wong, Dr. Steven Richmond Clinical Instructor Zaidel, Dr. Patrick Burnaby

The UBC Division of Community General Internal Medicine has been active in recruiting new members and is comprised of 44 members.

Division Overview

The Community General Internal Medicine Division is made up of internists who practice outside the teaching sites of the UBC system in Vancouver. Therefore, the group consists of community general internists in urban settings (Richmond, Vancouver, etc), suburban settings (Maple Ridge, Langley, etc) and other areas in the province (Nanaimo, Penticton, Kamloops and Kelowna). Furthermore, internists at the distributed sites of Victoria and Prince George fall into this group.`

To date, the efforts have been to recruit and credential (obtain faculty appointment) members to the CGIM division.

Members have diverse clinical interests and activities. The common interest of CGIM is of medical education. The membership has members who act in leadership roles in medical journal publications, medical societies (provincially and nationally), involved with non-medical activities (fiction writing) and CME, which is a large component of educational activities for this group. CME is done at sponsored (industry events), grand rounds and other venues. Dr. Steve Wong of Richmond is very active in CME involving in computers and technical advances to support physicians’ medical practices.

New Training Sites

Penticton has taken on the role of a training site for Internal Medicine’s Core Residents (in place of Nanaimo). Nanaimo, Victoria and Lions Gate Hospital have become training sites for Fellows in General Internal Medicine.

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Teaching

Teaching is a fundamental activity to this group. All members teach at both the undergraduate and postgraduate levels (in Internal Medicine). Members also teach Internal Medicine to other disciplines including family practice residents and residents from different Royal College specialties.

Some members have been involved for many years while others have recently joined the faculty. Some members are active in teaching every month while others only interact with medical students and resident trainees on an occasional basis.

The group’s cohesiveness is defined by its relationship to undergraduate program and postgraduate program in Internal Medicine and its fundamental commitment to the provision of consultative Internal Medicine Care to their hospitals and communities.

Research

Research to date has not been a focus of this group but will be an area for future faculty development.

Scholarly

Dr. Hector Baillie, a general internist from Nanaimo, is editor of the periodical Canadian Journal of General Internal Medicine. Along with being an active advocate for General Internal Medicine, he is in full-time clinical practice in Nanaimo.

Dr. MacRitchie is the Education (undergrad and postgrad) Coordinator for Prince George. Dr. Kevin McLeod, Dr. Chad Dyck and Dr. Steve Wong have taken on similar roles in their respective locations.

Dr. Jim Spence has taken on the role of CTU Director in Victoria. He has modified his practice and dedicates much of his time to teaching and administration for undergraduate medical student and residents in medicine and family practice. He has been awarded a special teaching award by the UBC medicine residents.

The members of the CGIM division are involved in the medical administration for the various hospitals and health care regions. There are some members who are active nationally in the Royal College, with oral and written examinations in Internal Medicine, as well as promoting the development and the values of General Internal Medicine in Canada. Drs. Kenyon and Ballie are examiners for the Royal College in Internal Medicine.

The medical school expansion is integral to the promotion of this division. The capacity to develop new training sites and new training directions is a primary focus of the CGIM Division’s teaching program.

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Clinical Services

The members of this group provide the Internal Medicine care to their respective communities. These activities include consultation to hospitals and outpatient groups, intensive care medicine, acute coronary care unit, pacemaker clinics, dialysis, perioperative and emergency services. In short, this group provides the entire spectrum of Internal Medicine services (in most communities) The CGIM group’s activities are absolutely essential to the function of all acute care facilities

Some of the Nanaimo internists, including Dr. Mike Kenyon, have volunteered and spent time in Kandahar, Afghanistan working in the field hospital and providing Internal Medicine services and critical care services to the military and civilians in this region.

Administration

The CGIM represents different health regions – Vancouver Island Health, Fraser Health, Vancouver Coastal, Interior Health and Northern Health Authority.

Dr. Paul Mitenko has been named Physician Program Director for the North Island (a section of Vancouver Island Health Authority) for the Medicine Program. He continues as well to practice and teach internal medicine. The members of the CGIM division are involved in the medical administration for the various hospitals and health care regions.

Activity

Recently a meeting was held in Vancouver to discuss some of the issues confronting the the division of CGIM. The meeting was attended by Drs. Chad Dyck, Don MacRitchie, Jim Spence, Kevin McLeod, Scott McKee, John Staples, Nasim Mahmoudi, Hector Baillie, Dave Forrest, Paul Mitenko, Shahin Jaffer, Steve Wong, Matt Bernard, Ric Arseneau and Barry Kassen. These people are educational leaders in CGIM and represent various communities in our province. The meeting had a CME component. This was presented by Dr. Dan Pratt and Dr. Ric Arseneau and was entitled “Why Can’t Everyone Be Like Me.”

The remainder of the meeting discussed the current shortage of general internists in the province and the potential consequences of this shortage. The group felt that there needed to be increased opportunities to train GIM and there needed to be a “new model”, with emphasis of community- based training sites and for a significant portion of the internal medicine core and fellowship groups.

Future Directions

There are many challenges and therefore many opportunities. The initial challenge is to organize a physically disparate division in order to have an administrative structure that provides a sense of “group cohesiveness. This is an ongoing activity that will be facilitated by site leaders who share the same goals.

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The prime future direction is to promote educational strategies and innovative learning opportunities at the different sites. It would be the aim of the CGIM Division to identify and evaluate the different strategies, and top potentially publish in this area.

Another important goal, perhaps the most important for the CGIM Division, is to provide an experience to trainees in GIM activities and to promote this practice and lifestyle to our trainees. These activities will serve to address the critical shortage of generalist physicians and may assure Canadians that there will be future general internists to live and work in their communities.

It is important to establish community Internal Medicine training sites that have trainees on a full- time basis. This would aid program innovation and development as well as assure faculty stability. We are developing such activities in several sites and will work toward expanding this in the future. As well, it will be important to develop “academic” site leaders and provide to these faculty appropriate administrative and financial support.

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CRITICAL CARE MEDICINE

Dr. Dean Chittock Clinical Assistant Professor & Head (Acting)

Faculty Members

Clinical Assistant Professor & Head (Acting) Chittock, Dr. Dean VA Professor Russell, Dr. James SPH Professor Walley, Dr. Keith SPH Clinical Professor Ronco, Dr. Juan VA Associate Professor Dodek, Dr. Peter SPH Assistant Professor Dorscheid, Dr. Delbert SPH Assistant Professor Hameed, Dr. Morad VA/SPH Clinical Associate Professor Tsang, Dr. John VA Clinical Assistant Professor Fenwick, Dr. John VA Clinical Assistant Professor Dhingra, Dr. Vinay VA Clinical Assistant Professor Forrest, Dr. David NRH Clinical Assistant Professor Grant, Dr. Gregory SPH Clinical Assistant Professor Henderson, Dr. William VA Boyd, Dr. John SPH Holms, Dr. Cheryl KGH MacRedmond, Dr. Ruth SPH Clinical Assistant Professor Keenan, Dr. Sean RCH Clinical Instructor Craig, Dr. Katherine RCH/VA Clinical Instructor Isac, Dr. George VA Clinical Instructor Yelle, Dr. Carole-Anne RHS Clinical Instructor Fava, Dr. Craig RHS/ RCH

Divisional Overview

The UBC Division of Critical Care Medicine is multidisciplinary in structure, with 18 faculty members, all qualified critical care specialists from Medicine, Surgery, Anaesthesia and Emergency Medicine backgrounds participating in patient care at St. Paul’s Hospital, Royal Columbian Hospital, Richmond General Hospital, Kelowna General Hospital, Nanaimo Regional Hospital and Vancouver General Hospital. The Division continues to plan expansion in 2008/09 and is seeking to recruit faculty with interest in epidemiologic research, translational biology,

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education, and health services research. The two-year Critical Care Medicine subspecialty- training program is fully accredited and has also expanded to accept three trainees per year with plans to add a fourth position in 2009. The Research Program in Critical Care Medicine is comprehensive, spanning from molecular and cellular biology through large animal models to clinical research in critically ill adults. The basic science research program is based in the Cardiopulmonary Laboratories at St. Paul’s Hospital. The clinical research program is focused in the intensive care units of St. Paul’s Hospital, Royal Columbian Hospital and Vancouver General Hospital.

Teaching

The University of British Columbia Adult Critical Care Medicine Training Program, under the direction of Dr. Katherine Craig, continued at the British Columbia Children’s, St. Paul’s and Vancouver General Hospitals. In 2007/2008 there were 6 trainees in the Adult Critical Care Medicine Fellowship Training Program. The ICU rotations for speciality residents from Medicine, Anaesthesia and Surgery continued to be highly rated at both St. Paul’s and Vancouver Hospital. Under the direction of Dr.Vinay Dhingra the VGH critical care group has purchased a SimM in order to further develop our education mandate into the realm of simulation medicine. It provides a portable advanced patient simulator for team training. We will find this device useful for local and distance training of health care providers in basic and advanced principlals of critical care medicine.

We also have a working relationship with CESEI, (Centre of Excellence for Surgical Education and Innovation) to further develop and expand and achieve excellence in medical education and research related to educational technology as it relates to critical care. As a part of this inititive, participation in the SCCM Critical Care Support Course continues to expanded to include core residents from all UBC Departments as well as hospitalists, rapid response team members, nurses and respiratory therapists.

The fifth annual Canadian Critical Care Conference was again held this year in Whistler. The program, chaired by Dr. Dean Chittock, was again a great success, with increasing local, national and international attendance.

Research

The Research Program in Critical Care Medicine is comprehensive, spanning from molecular and cellular biology through large animal models to clinical research in critically ill adults. The basic science research program is based in the Cardiopulmonary Laboratories at St. Paul’s Hospital. The clinical research program is focused in the intensive care units of St. Paul’s, Royal Columbian and Vancouver General Hospital.

Basic Science A new and exciting change in the direction of some of the basic science research has occurred in the area of Genomics of Critical Care (Russell, Walley). The two major current themes of this research are (1) the genetics of the systemic inflammatory response syndrome (SIRS) and sepsis and (2) randomized controlled trials in the critically ill. Genomics of critical care and sepsis

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involves doing studies in the critically ill of SNP’s and haplotypes of key inflammatory and innate immunity genes. The focus is on refining the clinical phenotypes of organ dysfunction in the critically ill. In addition this research program is looking at gene association studies of candidate genes in: (1) critically ill ICU patients who have SIRS, sepsis, and septic shock and (2) cardiovascular surgery patients. Specifically this group is looking at Influence of polymorphisms on coagulation and inflammatory mediator genes on phenotype post cardiopulmonary bypass surgery. (Walley, Russell).

Dr Russell has a CIHR gene environment grant to study haplotypes of susceptibility genes in cardiac, pulmonary and vascular disease ($2,756,473 over 5 years). In addition Dr Russell has obtained peer-review grant funded studies of the association of genotype with phenotype in SIRS in the critically ill, SIRS after cardiopulmonary bypass (Co- PI of a grant from CIHR), in ARDS (grants from BC Lung Association and Providence Health Care) and in acute lung injury (funded by NIH SCCOR /University of Washington contract).

The main findings to date have been focused on key innate immunity and inflammatory genes. These investigators have found significant relationships of genetic markers (specific haplotypes and single nucleotide polymorphisms (SNPs)) of protein C, IL-6, IL-10 and fibrinogen with increased risk of death. In contrast, genetic variants of key innate immune genes CD14, MBL, TLR-2 are associated with increased risk of severe infections. (Russell, Walley)

Work looking at Toll-like receptor signaling in the heart has been undertaken by this group recently as well. (Boyd, Walley)

Work also continues examining the mechanism of hypoxemia, blood flow, and redistribution of ventilation in acute pulmonary thromboembolism (Dr. Tsang).

Clinical Research

The clinical research program are undertaken at St. Paul’s, Royal Columbian and Vancouver General Hospitals. Most programs have carried over from last year with studies on the role of genotype and phenotype in sepsis and systemic inflammatory states (Drs. Walley and Russell), clinical trials and epidemiology of organ dysfunction in critical illness (Dr. Russell), glucose control and outcomes in the critically ill (Drs. Dhingra, Chittock, Ronco, Dodek, Henderson), recognition, quantification and treatment of delirium in the ICU (Dr. Chittock), the role of organizational factors and organizational culture in outcomes of critical care (Drs. Dodek, Keenan and Henderson), effect of sedation and agitation on duration of mechanical ventilation (Dr. Chittock), communication and decision making in end of life care (Dr. Dodek), patient safety teams and determinants of outcome in ICU (Drs Dodek, Chittock and Keenan), and blood transfusion and cerebral oxygenation in head injury (Drs. Chittock). Studies on the impact of sleep deprivation on patient safety in the ICU also a focus in 2007/08 (Ayas, Dodek, Ronco).

We are also continue to work in association with the Victorian Trauma Foundation, ANZIC Research Foundation, WA Institute for Medical Research and National Health & Medical Research Council to participate in a multicentre, prospective trial of early decompressive craniectomy in patients with severe traumatic brain injury (Ronco)

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A significant amount of activity and accomplishments occurred this year in the clinical research activities of the division. A pivotal, multicentre, randomized controlled trial of vasopressin vs. norepinephrine in septic shock (VASST Trial) was completed and published in the New England Journal of Medicine. Congratulations Dr. Russell (Principle investigator) (Russell, Walley). The VASST study will be used in the next draft of the international sepsis treatment guidelines. Dr Russell is also involved in the creation of a resuscitation consortium through a NIH grant for a proposal to create a Canadian collaborative regional clinical center within the resuscitation research consortium.

The division will be finishing off recruitment of a CIHR funded multi-centre trial examining glucose control in the ICU (Drs. Dhingra, Henderson, Chittock, Ronco, Dodek). This large study of 6100 patients is due to stop recruitment in Aug 2008 and will be one of the largest ever critical care studies performed. Publication is planned for 2009.

Health Services research continues to be a focus of some members of the group, led by Dr. Dodek. (Dodek, Chittock, Keenan, Hameed). Work in this new area of concentration is funded from various sources including: Michael Smith Foundation for Health Research—Investigative Teams Program ICU Patient Safety Team (Dodek, Chittock, Keenan) Canadian Institutes for Health Research—Partnerships for Health System Improvement for The Relationship between Organizational Culture and Family Satisfaction in Critical Care (Dodek, Chittock, Keenan). Canadian Patient Safety Institute The Impact of Sleep Deprivation, Circadian Misalignment, and Sleep Inertia on Patient Safety in the Intensive Care Unit- A Patient Simulator Study (Dodek, Ronco). Canadian Patient Safety institute; Critical Care Vital Signs Monitor: A scorecard for safe and effective patient care in the ICU (Chittock).

Clinical Services

The ICUs at St. Paul’s and Vancouver Hospital continued to experience an increase in occupancy and workload with over 1800 admissions at the two sites. An increase of 13% over previous. The ICUs at St. Paul’s Hospital and Vancouver General Hospital have continued to grow, reaching 15 and 27 beds in size respectively. Division members from St. Paul’s, Vancouver General and Richmond General Hospitals participated as members of the Regional Critical Care Council and continue to develop and implement strategies to improve the delivery of critical care services within the region. It is the goal of the regional critical care council to improve access, patient flow and sustainability through appropriate design and efficiencies and to implement best practices to improve health outcomes. Building on this theme, and a three-month pilot in fall 2004 at VGH, findings indicated that there were significant gains to be made in patient outcomes and care management with an Intensivist-led ICU Outreach program at the quaternary/tertiary sites, resulting in a business case that was developed and submitted for FY 2007/08 VCH business case cycles.

Insufficient bed capacity remains the largest challenge in provision of adequate, safe and timely care to the critically ill of the province. Process improvements have allowed us to increase this capacity by about 20% but further significant improvements are unlikely resulting in problems with patient access to critical care services that are predicted to increase to unsafe levels over this next year.

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Future Directions

The Division continues to explore ways to obtain increased recruitment of both clinical and basic science researchers to expand our research capacity and collaborations. We also hope to recruit a academic intensivist with an interest in medical education to help expand our role in medical education at the undergraduate and postgraduate level. Under the direction of Dr. Vinay Dhingra, the Division will continue to expand the implementation of a new critical care education format inclusive of simulation training. Our research capacity and productivity continues to expand. Collaboration between sites has been increasing and continued increases in collaboration for the next year is expected and desired. The CCM fellowship program continues to expand and we expect that with greater clinical workload, that expansion of the program at VGH and SPH will occur.

Special Honours and Awards

Dr. Dean Chittock assumed the role of PI of the SUGAR trial. Dr. Chittock was also acknowledged for significant efforts in implementing revised sedation protocols at VGH ICU which impacted patient safety, quality of care and a reduced ICU LOS. The “Vancouver Interaction and Calmness Scale” was recommended by the Society of Critical Care Medicine to be adopted for ICU care of ventilated patients. He continues to serve as organizer and session moderator at the Canadian Critical Care Conference, Whistler, BC.

Dr. Greg Grant deserves recognition for work in earlier recognition for SPH in early goal-directed care protocols for sepsis and septic shock through a care team.

Dr. Peter Dodek continues his work on the executive of the Canadian Critical Care Trials Group. He has received several grant awards to pursue his research in the area of patient safety in the ICU.

Dr. Juan Ronco was promoted to Clinical Professor and continues as the Vice Chair, Examination Board in Critical Care Medicine, Royal College of Physicians and Surgeons Canada. Examiner & Member of the Board of Examiners in Internal Medicine, Royal College of Physicians and Surgeons of Canada.

Dr. Jim Russell was the recipient of a Doctoral Research Award from the Institute of Genetics. Dr Russell was an invited speaker at the 36th Critical Care Congress, Society of Critical Care Medicine. Orlando, Fl, USA. February 18th-19, 2007; Roundtable Conference on metabolic support in sepsis and MOF. 27th Brussels Emergency and Intensive Care Medicine Conference, Brussels, Belgium. March 24, 2007; American Thoracic Society Annual Meeting, San Francisco, CA. May 20-23rd, 2007; Canadian Critical Care Conference, Whistler, BC, Canada. January 25, 2007; and 37th Critical Care Congress, Society of Critical Care Medicine. Honolulu, HI, USA. February 5-6th, 2008.

Dr. Keith Walley was an invited speaker and moderator at the 27th International Symposium on Intensive Care and Emergency Medicine, Belgium, Brussels, March 27 – 30, 2007, and American Thoracic Society Annual Conference, San Francisco, CA, USA, May 23 – 27, 2007.

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Dr. Walley continues as Senior Faculty Member, Faculty Appointments, Reappointments, Promotion and Tenure Committee, UBC Faculty of Medicine. He is a Distinguished Scholar, Michael Smith Foundation and Member, Michael Smith Foundation for Health Research, Research Advisory Council, and Clinical Research Evaluation Committee.

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ENDOCRINOLOGY

Dr. Ehud Ur Dr. David Thompson Professor and Head Clinical Assistant Professor & Head (Sept 1, 2007 – present) (Jan 1 – Aug 31, 2007)

Faculty Members

Professor and Head Ur, Dr. Ehud VA & SPH Professor Prior, Dr. Jerilynn VA Clinical Assistant Professor Thompson, Dr. David VA Clinical Associate Professor Dahl, Dr. Marshall VA Clinical Associate Professor Tildesley, Dr. Hugh SPH Clinical Assistant Professor Bebb, Dr. Richard SPH Clinical Assistant Professor Elliott, Dr. Thomas VA Clinical Assistant Professor Gill, Dr. Sabrina SPH Clinical Assistant Professor Kendler, Dr. David VA Clinical Assistant Professor Kreisman, Dr. Stuart SPH Clinical Assistant Professor Miller, Dr. David Victoria Clinical Assistant Professor Priestman, Dr. Barbara New Westminster Clinical Assistant Professor Sirrs, Dr. Sandra VA Clinical Assistant Professor Wallace, Dr. Clarissa VGH Clinical Assistant Professor Francis, Gordon SPH Clinical Instructor Klinke, Jennifer New Westminster Clinical Instructor Fung, Dr. Michelle VA Clinical Instructor Johnson, Dr. Michelle SPH Clinical Instructor Kong, Dr. Jason VA Clinical Instructor Mase, Dr. Robert SPH Associate Member Bondy, Dr. Greg SPH Associate Member Rothstein, Dr. Ralph BC Children's Hospital Associate Member Stewart, Dr. Laura BC Children's Hospital Associate Member Chanoine, Dr. J-P BC Children’s Hospital

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Associate Member Panagiotopoulos, Dr. Dina BC Children’s Hospital Associate Member Metzger, Dr. Daniel BC Children’s Hospital Adjunct Professor Finegood, Dr. Diane Burnaby Professor (Emeritus) Dawson, Dr. Keith VA Associate Professor (Emeritus) Cairns, Dr. Alexander Clinical Professor (Emeritus) Wilkins, Dr. Graeme VGH

Division Overview

2007 was a very exciting year for the Division of Endocrinology with recruitment of a new Division Head (Dr. Ehud Ur), a new Program Director (Dr. Breay Paty) and a new Research Director (Dr. Gordon Francis). With these substantial appointments in the later half of the year the Division is poised for significant development in the coming period.

Teaching

Undergraduate The Division of Endocrinology is an active participant in the Endocrinology & Metabolism Block of the 2nd year undergraduate curriculum (FMED). Division members are preceptors in the problem-based learning sessions and provide lectures to the undergraduate class. The division members at both the St. Paul’s Hospital and Vancouver Hospital sites have also been actively involved in 3rd and 4th year undergraduate electives, providing clinical instruction in outpatient clinics and inpatient hospital management, as well as presenting formal teaching sessions to the senior students throughout the year. Some division members serve as attending physicians on CTU and are involved in teaching internal medicine to clinical clerks.

Postgraduate The UBC Division of Endocrinology has a 2 year subspecialty training program which received full 6 year accreditation by the Royal College in 2007. The program has one internally funded training position per year and offers a second position to well-qualified externally funded applicants for a total of four subspecialty residents. In addition, the Division provides one month rotations for core internal medicine residents at both Vancouver General and St. Paul’s Hospital. Careful planning is required to provide a thorough grounding in the principles of endocrinology within the constraints of a one month rotation. With the expected expansion of the medical school, the demand of endocrinology teaching is likely to grow. We are currently planning how to best meet this increased demand.

Community Our division provides an increasing number of educational activities to community physicians. We run annual courses such as the Diabetes Directors Symposium and BC Endocrine Days as well as participating in departmental courses such as the Annual Reviews of Internal Medicine. Division members continue to provide a large number of invited lectures to community physicians across the province. Dr. Prior has a very active web-site that allows people all over the world to learn about her research in the area of women’s health.

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Committees • Dr. Ur is the chair of the Canadian Diabetes Association, a member of the Endocrine Society and American Diabetes Association and is on the board of Directors for Obesity Canada, is a member of the Clinical Expert Review Panel for Diabetes of the Canadian Agency for Drugs and Technology in Health (CADTH) and also serves as a member of the Special Advisory Committee on Metabolic therapies to Health Canada • Dr. Dahl serves on the Medical Services Commission of British Columbia and is a member of the Clinical Expert Review Panel for Diabetes of the Canadian Agency for Drugs and Technology in Health (CADTH) • Dr. Tildesley is the Chair of the organizing committees for B.C. Endocrine Days, Kelowna Endocrine Days and the Diabetes Directors Seminar

• Several division members are involved in the preparation of the 2008 Canadian Diabetes Association’s Clinical Practice Guidelines: Dr. Thompson (Chair Diabetes in Pregnancy section, steering committee), Dr. Dawson (aboriginal issues, steering committee), Dr. Tildesley (insulin therapy in type 1) and Dr. Bebb (erectile dysfunction), Dr Ur (Chair Diagnosis and Prevention, steering committee) • Dr. Sirrs is on the national committee for Fabry’s disease. • Dr. Prior is the President for 2007-2009 of the International Society for Menstrual Cycle Research • Dr Gill is a member of the Publications committee in the Endocrine Society and on the Task forces for Endocrine Mentoring, Endocrine Fellows and Endocrine Clubs with the Endocrine Society as well as on the Communications committee in Women in Endocrinology • Several division members serve as expert reviewers for medical journals and national grants competitions. • Dr. Kendler is President of the International Society for Clinical Densitometry • Dr. Paty is a chapter author for the CDA Clinical Practice Guidelines, an Associate Editor for the Canadian Journal of Diabetes, a Grant reviewer for the Canadian Diabetes Association and a manuscript reviewer for the journal “Diabetes”. • Dr. Elliott is the Chair, Endocrinology & Metabolism Society of BC • Dr. Francis is on the CIHR Metabolism Grants Panel - Regular internal member and Heart and Stroke Foundation of BC and Yukon Research Advisory Committee

Research

Research presentations by our residents and fellows at the Resident Research Day continue to be highly with several awards, including for best overall presentation. Most division members are involved in a number of areas of clinical research with the major ones listed below:

• Dr. Ur: diabetes (clinical trials, health care delivery models), lipids, obesity, neuroendocrinology (clinical trials), basic laboratory studies on adipokines. • Dr. Francis: basic and clinical research on dyslipidemias, HDL formation, lysosomal cholesterol storage disorders, atherosclerosis, smooth muscle cell biology, and LDL apheresis. • Dr. Dawson: diabetes care in First Nations communities, clinical trials • Dr. Elliott: clinical trials, President of the BC Endocrine Research Foundation • Dr. Fung: islet cell transplantation, inpatient diabetes care delivery

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• Dr. Kong: diabetes in pregnancy, clinical trials • Dr. Sirrs: adult metabolic disease, lipid disorders • Dr. Prior: women’s health, osteoporosis • Dr. Dahl: evidence-based review of diabetes health care delivery and transgender health • Dr. Thompson: islet cell transplantation, diabetes in pregnancy • Dr. Bebb: male reproductive health • Dr. Prior: menstrual cycles, ovulation, perimenopause, progesterone therapy, hot flushes treatment and epidemiology, osteoporosis epidemiology • Dr. Tildesly: diabetes care, clinical trials, lipid lowering in type 2 diabetes, • Dr. Kreisman: thyroid disease, cystic fibrosis and diabetes • Dr. Gill: women’s health • Dr. Kendler: osteoporosis • Dr. Johnson: pituitary disease • Dr. Paty diabetes, islet transplantation and the endocrine consequences of bone marrow transplantation.

Clinical Services

The Division of Endocrinology provides consulting services to Vancouver General, St Paul’s and BC Women’s hospitals. We also are involved in a number of specialized, multidisciplinary outpatient clinics:

Diabetes: Vancouver General, St Paul’s, BC Women’s Lipid: St Paul’s Osteoporosis: Women’s Adult Metabolic: Vancouver General

Future Directions

The division will be focusing on expanding the activities described above as well as recruiting new members to meet the increased teaching requirements needed for the medical school expansion. The division plans to develop multidisciplinary pituitary and thyroid clinics over the next year.

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GASTROENTEROLOGY

Dr. Eric Yoshida Associate Professor & Head

Faculty Members

Professor Freeman, Dr. Hugh VA Professor Steinbrecher, Dr. Urs VA Associate Professor Salh, Dr. Baljinder Singh VA Associate Professor Yoshida, Dr. Eric VA Assistant Professor Tai, Dr. Isabella VA Clinical Professor Halparin, Dr. Lawrence SPH Clinical Associate Professor Byrne, Dr. Michael VA Clinical Associate Professor Enns, Dr. Robert SPH Clinical Associate Professor Gray, Dr. James VA Clinical Associate Professor Kwan, Dr. Peter VA Clinical Associate Professor Weiss, Dr. Alan VA Clinical Assistant Professor Amar, Dr. Jack VA Clinical Assistant Professor Atkinson, Dr. Kenneth New Westminster Clinical Assistant Professor Chatur, Dr. Nazira VA Clinical Assistant Professor Erb, Dr. Siegfried VA Clinical Assistant Professor Lam, Dr. Eric SPH Clinical Assistant Professor Pearson, Dr. David Victoria Clinical Assistant Professor Penner, Dr. Robert Kelowna Clinical Assistant Professor Ramji, Dr. Alnoor VA Clinical Assistant Professor Singh, Dr. Ranjit Victoria Clinical Assistant Professor Telford, Dr. Jennifer Victoria Clinical Assistant Professor Whittaker, Dr. J. SPH Clinical Instructor Bressler, Dr. Brian Clinical Instructor Chung, Dr. Henry New Westminster Clinical Instructor Fishman, Dr. Martin Richmond Clinical Instructor Ho, Dr. Jin Kee VA Associate Professor (Emeritus) Anderson, Dr. Frank VA Associate Professor (Emeritus) MacDonald, Dr. Walter Clinical Professor (Emeritus) Chaun, Dr. Hugh SPH Clinical Professor (Emeritus) Stordy, Dr. Stanford

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Divisional Overview

The UBC Division of Gastroenterology consists of the faculty of two main teaching hospitals, Vancouver Acute (Vancouver General Hospital and UBC Hospital), and St. Paul’s Hospital (Providence Healthcare). As well, we have faculty in distributed sites. These sites include Richmond General Hospital, Royal Columbian Hospital and Lion’s Gate Hospital in the Lower Mainland, the Victoria and Vancouver Island Hospitals and in Kelowna. The faculty consists of GFT as well as Clinical Faculty Association members. We have associate members who were appointed by the Associate Dean of distributed sites as well as associate members who have areas of academic interest in common with the Division of Gastroenterology. We also have four emeritus faculty and one visiting faculty member.

Clinical Services

Full clinical in-patient and out-patient services are provided at the teaching hospitals as well as the distributed hospital sites. In particular, the main teaching hospitals, Vancouver General Hospital and St. Paul’s Hospital are provincial quarternary hospitals and are the main destinations for patient transfers from community hospitals throughout BC and the Yukon Territories via BC Bedline and the “Life, Limb or Transplant” policy. Specialized therapeutic endoscopy consisting of ERCP, both diagnostic and therapeutic, is offered as a clinical service at the Vancouver General Hospital, St. Paul’s Hospital and Royal Columbian Hospital sites in the lower mainland and at the Victoria Hospital Corporation institutions. The specialized modalities of endoscopic ultrasound and capsule endoscopy are available at St. Paul’s Hospital but are not available at the Vancouver General Hospital. Endoscopic ultrasound is available at the BC Cancer Agency Vancouver Clinic and is performed by VGH faculty with cross-appointments (Dr. Alan Weiss and Dr. Michael Byrne). As well, the Division is involved in clinical activity with the British Columbia Transplant Society and the British Columbia Cancer Agency (PHSA). The BC Hepatitis Program, which is a partnership of the BC Centre for Disease Control and the UBC Division of Gastroenterology, is actively involved in clinical services related to viral hepatitis and liver disease. It is located within the Division of Gastroenterology’s block in the Diamond Health Care Centre of the Vancouver Hospital. The St. Pauls’ Hospital group, Pacific Gastroenterology Associates, also offers specialized out-patient care in luminal gastroenterology and viral hepatitis. Dr. Frank Anderson has a large private office group (the Liver and Intestinal Research Centre) that offers out-patient services including out-patient endoscopy.

Teaching

Undergraduate: The Division of Gastroenterology is an active participant in the GI Block of the 2nd year undergraduate curriculum (FMED 424). Division members provide lectures to the undergraduate class as well as participate as preceptors in the problem-based learning sessions as well as the hepatology seminars. Drs. Bill Salh and Eric Yoshida are the Block Co-Chairs and Drs. Peter Kwan and Eric Yoshida have been Week Chairs for FMED 424.

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The division members at both the St. Paul’s Hospital and Vancouver General Hospital sites have also been actively involved in 3rd and 4th year undergraduate selectives. Clinical instruction at both the bedside and out-patient clinics are offered to the undergraduate class yearly. Dr. Nazira Chatur is currently the Undergraduate Program Director for Gastroenterology for these clinical years.

Postgraduate: The Division of Gastroenterology has a strong Gastroenterology fellowship training program. The core program consists of two senior GI Fellows, Drs. Joanna Law and Justin Shah and two junior GI fellows, Drs. Hin Hin Ko and Darin Krygier. Dr. Law is also the appointed Chief Gastroenterology Fellow. The training program has many applicants both internally and externally each year and competition for GI fellowship positions has become increasingly fierce. Dr. Nazira Chatur is the Program Director and Dr. Peter Kwan is the Associate Program Director. In addition to the Program Director and the Associate Program Director, there is a Fellowship Training Committee that includes representation from both teaching hospitals, the community group and a trainee representative. The training committee members, aside from Drs. Chatur and Kwan, include Drs. Justin Shah (Fellow), Alnoor Ramji, Eric Lam, Bill Salh, Marty Fishman and Eric Yoshida. In February 2007, the GI fellowship training program was reviewed by the Royal College and received full accreditation. Next year’s trainees are Drs. Janakie Singham and Holly Weisinger.

The Division of Gastroenterology offers specialized training programs beyond the core Royal College Gastroenterology Fellowship Program. For many years we have had the liver transplantation and hepatology training program based at the Vancouver General Hospital in association with the BC Transplant Society. The current Hepatology/Liver Transplantation Fellows are Dr. Pongphob Intaraprasong (Bangkok Thailand), and Dr. Wichian Apiratpracha (Bangkok, Thailand). The Division of Gastroenterology also has a formal therapeutic endoscopy training program. Drs. Rob Enns and Mike Byrne are the co-directors. All the therapeutic endoscopists of St. Paul’s Hospital and Vancouver General Hospital are involved in this including Drs. Eric Lam, Jennifer Telford, Urs Steinbrecher and Alan Weiss. A non-therapeutic endoscopist division member will serve in an advisory role. Dr. Eric Yoshida was appointed by Drs. Enns and Byrne for this year. The therapeutic endoscopy training program will involve diagnostic and therapeutic ERCP and endoscopic ultrasound. The current Therapeutic Endoscopy Fellow is Dr. Mark McLaughlin of Ireland.

Experimental Medicine: Dr. Bill Salh co-ordinates the gastroenterology aspects of the experimental medicine program at UBC. The program involves graduate students registered in experimental medicine as well as summer students and post-doctoral fellows.

Continuing Medical Education: The UBC Division of Gastroenterology has organized several CME conferences and both the Vancouver General Hospital and St. Paul’s Hospital Divisions organize a weekly Gastroenterology/General Surgery/Radiology/Pathology multi-disciplinary rounds that is accredited for the Royal College of Physicians and Surgeon Maintenance of Competence Program. Dr. Rob Enns organizes the annual GI Forum held in the Fall which as been well

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attended and received favourable evaluations. The UBC Division of Gastroenterology also organized the 12th Annual Digestive Diseases Week Review for sub-specialists. This was also very well attended and received favourable comments from attendees. The BC Hepatitis Program co-organized the “Liver Update” conference with the BC Centre for Disease Control and the Chinese Canadian Medical Society. This was also well attended and well received.

Many of our division members have participated in national and international CME events including the tele-rounds of the Canadian Association of Gastroenterology, Canadian Digestive Diseases Week (the annual meetings of both the Canadian Association of Gastroenterology and the Canadian Association for the Study of Liver). Of special note, Dr. Robert Enns was invited to present two CME lectures on capsule endoscopy and ERCP at the American Society of Gastrointestinal Endoscopy (ASGE) meeting held in Washington DC in association with Digestive Diseases Week, and Dr. Eric Yoshida gave an invited CME presentation on the use of bone marrow growth factors as adjuvant hepatitis C therapy at the American Association for the Study of Liver Meeting (AASLD) in Boston MA. Numerous CME lectures were provided by Division members for local organizations such as the Canadian Liver Foundation, BC Centre for Disease Control, Gut Club, Advances in Medicine in the 21st Century Day as well as local hospital rounds and lectures for the Canadian Society of Gastroenterology Nurses and Associates (CSGNA).

Administration

Clinical Academic Special Programs: The UBC Division of Gastroenterology members are involved in several specific and specialized clinical academic programs. Dr. Alan Weiss is a member of the BC Cancer Agency Hepatoma Program. Both Dr. Weiss and Dr. Siegfried Erb are involved in multi-disciplinary hepatoma rounds that involves the UBC Division of Gastroenterology, the UBC Division of General Surgery, and the Vancouver General Hospital Department of Interventional and Abdominal Radiology. This multi-disciplinary group is involved in clinical decision making for hepatocellular carcinoma cases referred from communities throughout the province. It is also involved in clinical research in the area of liver cancer.

Drs. Erb, Steinbrecher and Yoshida (Medical Director) are members of the Liver Transplant Program of the BC Transplant Society. This provincial program provides clinical care to post- liver transplant recipients, assessment of end-stage liver disease patients referred to the Transplant Society, as well as administrative leadership both at a provincial and national level and both clinical/basic science research in the field.

The BC Hepatitis Program, which is a partnership of the BC Centre for Disease Control and UBC Division of Gastroenterology, is situated within the Division of Gastroenterology’s block in the Diamond Health Care Centre of the Vancouver Hospital. Its members include Drs. Erb, Steinbrecher, Kwan, Weiss, and Yoshida (Head of the BC Hepatitis Program). The BC Hepatitis Program staff includes Ms. Jo-Ann Ford (Associate Director), Ms. Cindy Cheong-Lee (Assistant Director), Ms. Barbara Chick (hepatitis nurse) and Messrs. Kirby Lau, Nicholas Grant and Ms. Sandy Nghiem (clinical research assistants). The program is involved in clinical care and patient teaching in the area of viral hepatitis and liver disease. The BC Hepatitis Program is actively

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involved in clinical research with industry sponsored clinical trials and non-industry sponsored clinical studies. There are close collaborative research partnerships with BCCDC and the UBC Virology Laboratory. The BC Hepatitis Program is actively involved in continuing education at all levels and has organized CME events. It is also involved actively in nursing education and is part of the UBC Faculty of Pharmaceutical Sciences PharmD program with preceptorship of clinical rotations as well as the provision of formal class lectures. At the national level, Ms. Jo- Ann Ford is the current President of the Canadian Association of Hepatology Nurses and Dr. Eric Yoshida is the President-Elect of the Canadian Association for the Study of Liver (CASL). The BC Hepatitis Program has been involved with the Canadian Liver Foundation and Ms. Ford serves on the National Board of Directors.

Research

The faculty of the Division of Gastroenterology are very involved in both clinical and basic science research. Drs. Salh, Steinbrecher and Tai are actively involved in basic science research programs supported by national and provincial granting agencies including CIHR, HSFC, CCFC, and the Canadian Society for Intestinal Research (CSIR). Clinical research is very strong within the Division of Gastroenterology and appears to be expanding. The specific areas of clinical research within the Division have encompassed: liver disease, viral hepatitis, liver transplantation as well as solid organ transplantation and donation, inflammatory bowel disease and therapeutic endoscopy. Dr. Rob Enns has a clinical trials unit located at the Pacific Gastroenterology Associates office block. Dr. Enns is also actively involved in non-industry clinical research and has developed outstanding clinical research expertise in capsule endoscopy and therapeutic endoscopy. He has published many publications this year in these areas Dr. Eric Lam is also actively engaged in clinical research in the field of endoscopic ultrasound. Dr. Brian Bressler, is establishing a clinical research program in inflammatory bowel disease. At the Vancouver General Hospital and Health Sciences Centre, Dr. Hugh Freeman continues to be a prolific author of many clinical research papers in inflammatory bowel disease and celiac disease. The BC Hepatitis Program and the Liver Transplant Program of the BC Transplant Society have been very active in clinical research both in industry sponsored clinical trials and non-industry sponsored clinical studies. The BC Hepatitis Program and Dr. Anderson’s private LAIR Centre are co-investigators in a CIHR sponsored hepatitis C study with the University of Toronto. The Division of Gastroenterology at Vancouver General Hospital also has some non-hepatology industry-sponsored clinical trials ongoing under the leadership of Dr. Jim Gray. It is expected that clinical research will continue to expand at both the main teaching hospitals and is a major strength of the Division

Special Honours, Awards and Distinctions

Notable Service to the University and the Community: Many Division members serve on UBC, BCMA and other provincial committees and many Division members have served as reviewers of numerous Canadian and international peer-review journals and grant funding agencies. Both Drs. Rob Enns and Eric Yoshida are Associate Editors of the Canadian Journal of Gastroenterology (official journal of the Canadian Association of Gastroenterology and the Canadian Association for the Study of Liver). Dr. David Pearson is also on the Editorial Board of the Canadian Journal of Gastroenterology. Drs. Michael Byrne, Hugh

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Freeman and Eric Yoshida are on the Editorial Board of the World Journal of Gastroenterology and Dr. Freeman has recently been appointed the Associate Editor-in-Chief of the “Observations” section of the World Journal. Drs. Byrne and Yoshida are on the Editorial Board of the Internet Journal of Gastroenterology and Dr. Michael Byrne is an Editorial Consultant for the Physicians Information and Education Resource (PIER) published by the American College of Physicians. Dr. Eric Yoshida is a new appointee to the Editorial Board of Liver International, the official journal of the International Association for the Study of Liver (IASL). Dr. Hugh Chaun has been recently elected Vice President of the Bockus Internal Society of Gastroenterology and continues to serve as the Society’s Secretary General. Dr. Chaun is also the Chair of the Governing Board of the Canadian Digestive Health Foundation. Dr. Michael Byrne and Dr. Eric Lam are members of the National Endoscopy Committee of the Canadian Association of Gastroenterology which has Dr. Rob Enns as the Committee Head. Dr. Enns is also Head of the Capsule Endoscopy Special Interest Group of the American Society of Gastrointestinal Endoscopy. Dr. Eric Yoshida is a member of the Membership Committee and Nomination Committee of the Canadian Association for the Study of Liver (CASL) and is the President-Elect of the organization, taking office in March of 2008. He is also an Independent Councillor of the Governing Board of CASL and will join the National Board of Directors of the Canadian Liver Foundation in 2008. Dr. Frank Anderson is the President of the Canadian Society for Intestinal Research (CSIR) and Dr. James R. Gray is the Vice President of CSIR as was as the President of the BC Society of Gastroenterology. Drs. Nazira Chatur, Martin Fishman, Peter Kwan and Eric Lam are examiners for the Western Canadian Trainee Examinations in Gastroenterology (annual preparatory examination for the Royal College of Physicians and Surgeons specialist examination in gastroenterology). Dr. Scott Whitaker is an Examiner of the Royal College of Physicians and Surgeons for the Gastroenterology Subspecialty Certification Examinations. Dr. Urs Steinbrecher is the Chair of the CIHR Metabolism and Grant Panel and Chair of the Heart and Stroke Foundation of BC and Yukon Research Committee. He is also the Chair of the AHFMRA Clinical Investigative Review. At Royal Columbian Hospital, which is fast evolving into a teaching hospital, Dr. Ken Atkinson is Chief of the Medicine and Deputy Chair of the RCH Medical Advisory Committee.

Special Honours and Awards: Dr. Iman Zandieh, who recently completed his Gastroenterology Fellowship in June of 2007 was the recipient of the UBC Richard Beck Award for outstanding teaching by a UBC trainee. Dr. Bill Salh was the 2007 recipient of the Vancouver Coastal Health Research Institute “In it for Life” Clinician Scientist Award. The Professional Association of Residents of BC (PAR-BC) announced in late 2007 that Dr. Eric Yoshida was the recipient of the 2006 Resident Advocate Award. On the occasion of the 500th liver transplant, the Canadian Liver Foundation, BC and Yukon Chapter, bestowed its Tribute Award to the Liver Transplant Program. Drs. Siegfried Erb, Urs Steinbrecher and Eric Yoshida, as well as Ms. Jo-Ann Ford, the Associate Director of the BC Hepatitis Program, were recipients of a CLF Tribute Award along with the other members of the Liver Transplant Program.

Special Tributes: In remembrance of the outstanding teaching contributions of the late Dr. Donald M. Carr, who was our beloved colleague and clinician, the Division of Gastroenterology at Vancouver General Hospital created the Donald M. Carr Teaching Award to be given to the “Best VGH Faculty

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Teacher” as selected by the GI fellows, medical residents and medical students rotating through gastroenterology. The 2006-07 recipient was Dr. Siegfried R. Erb.

In honour of his outstanding contributions to Gastroenterology at UBC and throughout the Province of British Columbia, the UBC Gastroenterology Fellows created the Dr. Hugh Chaun Mentorship Award. Dr. Robert Enns was named the recipient for 2007.

Trainee Awards: The annual AstraZeneca Canada Gastroenterology Medical Residents Award were given to Drs. Myriam Farrah and Colm Murphy (VGH Hospital Site) and Dr. Natalia Rydz (SPH site). The Janssen Ortho Award for Best Surgical Resident rotating through Gastroenterology was awarded to Dr. Peter Kim. Dr Iman Zandieh was the Chief Gastroenterology Fellow for 2006-2007 and received a plaque from the Division for his outstanding service.

Future Directions

From a clinical perspective, there are many challenges facing the Division, including dwindling out-patient resources, and an increasing demand for in-patient admissions both via the Emergency Department and inter-hospital transfers via BC Bedline. In particular, the VGH Division is attempting to persuade its hospital to acquire endoscopic procedures and technologies (eg. Endoscopic ultrasound, lumenal stenting etc) that are considered standard of care elsewhere but are not provided for at that institution.

Academically, there has been great progress towards enhanced collegiality and co-operation between the two main teaching hospitals, the Vancouver General Hospital and St. Paul’s Hospital as well as the distributed sites in the community. It is anticipated that collaboration between these two institutions and the community sites will increase in the near future. The development of an Academic Financial Plan (AFP) by the University of British Columbia and the Government of BC would greatly enhance the Division of Gastroenterology’s academic productivity and ability to compete with other Canadian centres. Lastly, the Division hopes to enhance future collaborations with other Departments within the Faculty of Medicine (including the Department of Surgery, the Department of Radiology, Department of Laboratory Medicine and Division of Pediatric Gastroenterology),with other Divisions within the Department of Medicine, and with other healthcare institutions within BC and the rest of Canada.

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GENERAL INTERNAL MEDICINE

Dr. Barry Kassen Clinical Professor and Head

Faculty Members

Clinical Professor & Head Kassen, Barry SPH/VA Professor Birmingham, Dr. Laird SPH Professor Wright, Dr. James VA Associate Professor Palepu, Dr. Anita SPH Assistant Professor Khan, Dr. Nadia SPH Clinical Professor Ballem, Dr. Penny SPH Clinical Professor Mackie, Dr Iain VA/SPH Clinical Professor Onrot, Dr. Jake SPH Clinical Associate Professor Hatala, Dr. Rose SPH Clinical Associate Professor Kennedy, Dr. James SPH Clinical Associate Professor Magee, Dr. Laura BCWH/SPH Clinical Associate Professor Roberts, Dr. James Mark VA Clinical Assistant Professor Arseneau, Dr. Richard SPH Clinical Assistant Professor Busser, Dr. James VA/SPH Clinical Assistant Professor Dunne, Dr. James VA/SPH Clinical Assistant Professor Hawley, Dr. Phillipa BCCA Clinical Assistant Professor Ma, Dr. Irene VA/SPH Clinical Assistant Professor Ong-Lam, Dr. May SPH Clinical Assistant Professor Perry, Dr. Thomas VA Clinical Assistant Professor Wakefield, Dr. Robert VA Clinical Assistant Professor Ward, Dr. John SPH Clinical Instructor Chan, Dr. Alex Chong Hen SPH Clinical Instructor Cunningham, Dr. Kenneth SPH/LGH Clinical Instructor McCormick, Dr. Iain VA Clinical Instructor McKay, Dr. Rhonda SPH Clinical Instructor Purkiss, Dr. Susan BCWH Clinical Instructor Rosenbaum, Dr. Debbie VA Professor (Emeritus) Paige, Dr. Bruce VA Professor (Emeritus) Schulzer, Dr. Michael VA

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Associate Professor (Emeritus) Rangno, Dr. Robert SPH Associate Professor (Emeritus) Studney, Dr. Donald VA

Divisional Overview

The UBC Division of General Internal Medicine has 31 faculty, which participate in activities at BC Women’s and Children’s Hospital, BC Cancer Agency, Vancouver Acute and St. Paul’s Hospital. The specific site activities are varied. All members do not participate in all activities, nor do they necessarily participate at all sites. Our members are involved with Palliative Care (Dr. P. Hawley heads the program at the Vancouver Cancer Agency), Maternal-Fetal Medicine (Drs. L. Magee and S. Purkiss at BC Women’s and Children’s Hospital), as well as multiple programs and disciplines which include HIV care (Drs. Iain Mackie and Jake Onrot), Eating Disorders (Drs. Ric Arseneau and Jane McKay), Addiction Medicine (Drs. Alex Chan), Heart Failure Clinic (Dr. Mark Roberts) and UBC Sports Medicine (Dr. Mark Roberts) at the St. Paul’s Hospital and Vancouver Acute.

Basic to all the division is the provision of General Internal Medicine consultation (and ongoing care) provided by the membership. This may take place in an inpatient setting (clinical teaching unit), consultation service to inpatients, perioperative service or an ambulatory setting.

Amongst our membership, the GIM physicians provide expertise, core teaching and research in Addiction Medicine, Pain Management, Eating Disorders, Hypertension, HIV Management, Drug and Poison Control and Hemochromatosis. A division member is also involved in Scleroderma research and patient management.

Some of our members are involved in providing community-based care work in rural and urban settings, at times being responsible for Intensive Care Units as a prime clinical function (Drs. Ken Cunningham, Jane McKay, Rose Hatala).

Our members are program leaders in medical education, research and administration and are recognized locally and nationally in these areas.

Our membership has an emphasis on medical informatics and has strong well-recognized leadership in these areas. Dr. Ric Arseneau (development of web eval, etc), Dr. J. Busser (development of CTU Tracker) and Dr. Ken Cunningham (online medical grand rounds) are the active members, currently.

Teaching

The core element for the UBC Division of GIM is teaching. Dr. Mark Roberts is director of the Department of Medicine UBC Postgraduate Program and is supported by 3 co-directors, two of which are in the division. Recently Dr. Rose Hatala (and now Dr. Irene Ma) has the portfolio of evaluation and Dr. Kassen has portfolio of community rotations and distributed site (Victoria and Prince George) development.

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Dr. Roberts heads the CTU at Vancouver General Hospital (VGH) and Dr. Kassen at St. Paul’s Hospital (SPH). With the expansion of the undergraduate students at the distributed sites, all undergraduate students in Vancouver are taught at VGH or SPH. All of the postgraduate training in CTU’s and GIM clinics is done as well at these sites.

Trainees are also mentored in eating disorders, pain management, HIV and addiction medicine. We have a strong program in palliative care and maternal-fetal medicine (using a mentorship model). The CTU faculty is instrumental in the International Medical Graduate Program in both training and evaluation.

Drs. Jim Busser and Jim Dunne are current leaders in the Undergraduate Clerkship Program and are directors of this program at VGH and SPH respectively.

New initiatives have been adopted through the research and subsequent implementation of tools such as mini-cex (research and subsequent implementation in evaluation in the CTU setting) and pioneering the use of simulations in medicine (Dr. Irene Ma and Dr. Barry Kassen). The latter program will teach central line insertion (and has used this opportunity to study and publish in this area), as well as promote learning and evaluation using simulation models.

Our group is involved in CME in the university and in the community.

Research

Research is done at all sites but the major sites for our research activities has been SPH and BC Women’s Hospital and involves a core group of funded researchers with dedicated time for these activities. Dr. Anita Palepu is the senior researcher whose interest is in urban health and is a Michael Smith Foundation for Health Research Senior Scholar. She is widely published been an invited speaker to national and international meetings. Dr. Nadia Khan is very active in social determinants of cardiovascular disease. She has received many prestigious supporting grants including CIHR and Michael Smith Awards, and has received the CIHR New Investigator Award, the Genesis Scholar Award and the SPH Physician Scholar Award. She has a CIHR operating grant exploring gender and ethnic differences in patients with hypertension. Dr. Khan as well is a member of the Canadian Hypertensive Society Education and Research Group. She also serves as a scientific committee member of the Heart and Stroke Foundation Trainee Award Program.

Dr. Laura Magee continues her research in maternal-fetal medicine, concentrating on hypertension in pregnancy using randomized clinical trial methodology. She is supported by major grants from CIHR and holds a Michael Smith Foundation for Health Research Scholar Award and has been highly productive and widely recognized as a leader in her field.

Medical education research is a focus for Drs. Rose Hatala, Iain Mackie, Mark Roberts and Barry Kassen. Recently this group was awarded a Stemmler Grant (from the National Board of Medical Examiners from the USA) and completed this national study. There have been presentations and publications from this work. This group has also published their experience with the development of a quality improvement process for postgraduate first year trainees, and have been awarded a Royal College Grant to continue this work.

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Dr. Irene Ma has a research interest in ethnicity in health care delivery and recently has begun an interest in medical education. She has also developed a research interest in simulations in learning and evaluation.

Dr. Alex Chan is involved in a national study in heroin use (NAOMI Study).

Dr. Laird Birmingham is active in eating disorders research and publishes extensively in this area.

Administration

Members of the division play key roles in administration locally, provincially and nationally.

Drs Nadia Khan, Iain Mackie, Jake Onrot and Barry Kassen are on the Executive of the Rocky Mountain Review Course (a University of Calgary Internal Medicine initiative).

Dr. Anita Palepu is director of the Clinical Investigator Program, the Director of the GIM Fellowship Program. She is currently involved in the launch of a new open access general medical journal called Open Medicine http://www.open_medicine.ca. She is the President-Elect of the International Society of Urban Health and is the Chair of the Health Services Research Committee Career Awards Program at the Michael Smith Foundation for Health Research. Dr. Palepu is coordinating an international meeting to be held in Vancouver in the fall of 2008.

Drs. Bob Rangno and Tom Perry are members and active leaders in the UBC Therapeutics Initiatives –Education group.

Dr. Mark Roberts is CTU Director at VGH, Postgraduate UBC Director, a member of the GIM Fellowship Training Committee and a member of the Oral Examination Board of the Royal College in Internal Medicine.

Dr. Rose Hatala is research director for the Internal Medicine Examination Committee for the RCPC, an active member of the Oral Board in Internal Medicine and a member of the Faculty Development Group in the Faculty of Medicine. Dr. Hatala as well mentors researchers in medical education (in various departments) and medical educators.

Dr. Irene Ma is the associate program director postgraduate medicine and in charge of evaluation and development of simulations in learning.

Dr. Jim Busser is clerkship director (VGH) and Dr. Jim Dunne is clerkship director (SPH). Dr. Dunne is director of the Scleroderma Clinic at SPH.

Dr. Jim Kennedy is Director of the Hospitalist Program at Providence Health (St. Paul’s Hospital and Mt. St. Joseph Hospital).

Dr. Tom Perry directs the undergraduate program at UBC Site and is a member of the Therapeutics Initiative.

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Dr. Jane McKay is director of Ambulatory Care at SPH. Dr. Jim Busser has this position at VGH.

Dr. Barry Kassen is UBC division head, SPH division head, Vancouver Acute division head, Associate head Department of Medicine SPH, Acting Division Head Community Internal Medicine, CTU Director SPH, Associate Program Director (Core Internal Medicine), Representative to Rocky Mountain and Canadian Society of Internal Medicine, past Governor of British Columbia for the American College of Physicians, member of the UBC Internal Review Committee, Chair of the Provincial Albumin working Group, chair of the Internal Medicine Examination Committee (RCPSC), member of the Working Group in General Internal Medicine (RCPSC), member of the Evaluation Committee (RCPSC) and member of the Health and Policy Committee (RCPSC).

Future Direction

The division has been working very actively on an alternate funding system and sees this as a key component to fulfill its mandate. Innovation in health care delivery as well as education are the directions this would support. This is ongoing.

The continued emphasis on our medical education goals, as well as support of the distributed sites (Victoria and Prince George), will continue to be a divisional aim.

A regional approach to Internal Medicine with equal emphasis at both major general teaching hospital (VGH and SPH) and a recruitment strategy that would see the acquisition of clinical and research faculty at VGH and BC Women’s Hospital is a top priority.

The division has had 2 retreats this year with a significant focus on recruitment and new clinical activities. The aim of the division is to recruit the “new” fellows upon their completion of training and to recruit widely to enhance the aims of the division.

The clinical area of emphasis is the development of a perioperative service and a consultative service for VGH and St. Paul’s Hospital. Presently the division is working with Anesthesia and Surgery at both sites. The services are being developed and in conjunction with Anesthesia is trying to change the health care delivery for the preoperative patient. This has been done under the leadership of Drs. Iain Mackie and Jane McKay.

Support and modification of the Eating Disorders Medical Model has been advanced by Dr. Jane McKay. In association with Dr. Ric Arseneau they are changing the model of medicine involvement in the patients with anorexia nervosa.

The training of general internists for the community and the university is a high priority for the division.

New Recruits This year we welcomed Drs. Penny Ballem, Iain McCormick and Debbie Rosenbaum to the division. These recruits bring a variety of talents and are already enhancing the division of GIM.

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There is a current emphasis on reorganizing the ambulatory medicine program at St. Paul’s Hospital and VGH to promote academic as well as a clinical relevant service to the hospitals and communities. This has been done successfully and implementation of a perioperative service with the Preadmission Clinics of VGH and SPH are underway.

The research component of our members needs to be promoted and celebrated by the division of Internal Medicine, the faculty of the department of medicine and the appropriate research affiliates.

Finally, the division of Internal Medicine needs to take a leadership role in producing and advocating for more general internists for the university and community of British Columbia. The division of Internal Medicine is committed to this goal and sees this as one of its primary aims.

Honours and Awards

Dr. Iain Mackie (VGH) was awarded the Shelley Naiman Award for Outstanding Faculty Teaching at VGH.

Dr. Ric Arseneau was awarded the Shelley Naiman Award for Outstanding Faculty Teaching at SPH.

Dr. Debbie Rosenbaum was awarded the 2007-2008 SPH Graeme C. Copland and UBC Fay R. Dirks Award for Excellence in Teaching Award.

Barry Kassen was awarded the 2007 UBC Killam Teaching Prize.

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GERIATRIC MEDICINE

Dr. Janet E. McElhaney Professor & Head

Faculty Members

Professor & Head McElhaney, Dr. Janet VA/SPH Professor Meneilly, Dr. Graydon VA/SPH Assistant Professor Lee, Dr. Philip SPH Assistant Professor Madden, Dr. Kenneth VA Clinical Associate Professor Adler, Dr. Reva VA Clinical Associate Professor Dian, Dr. Larry VA Clinical Associate Professor Wong, Dr. Roger VA Clinical Assistant Professor Chung, Dr. Maria SPH Clinical Assistant Professor Hill, Dr. Amanda VA Clinical Assistant Professor Kushner-Kow, Dr. Janet St. Vincent's Clinical Assistant Professor O'Connor, Dr. Peter St. Mary's Clinical Assistant Professor Pillay, Dr. Shunmoogam (Willie) SMH Clinical Assistant Professor Rauscher, Dr. Christopher VA Clinical Instructor Alimoradi, Dr. Ima SPH Clinical Instructor Barnett, Dr. Kim SPH Clinical Instructor Bater, Dr. Marilyn Royal Jubilee Clinical Instructor Bell, Dr. Kathryn VA Clinical Instructor Cook, Dr. Wendy SPH Clinical Instructor King, Dr. Kim Nanaimo Clinical Instructor Menezes, Dr. Janice SPH Clinical Instructor Petrossian, Dr. Caroline SPH Clinical Instructor Ranchod, Dr. Hetesh Mount St. Joseph Clinical Instructor Williams, Dr. Dorothy Victoria Associate Member Sheldon, Dr. Leslie Mount St. Joseph Professor (Emeritus) Beattie, Dr. B VA

Divisional Overview

The Division of Geriatric Medicine currently has 13 faculty members within Vancouver Acute (VA) and Providence Health Care (PHC) and 2 faculty members in distributed sites. Emeritus

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Professor, Dr. Lynn Beattie, remains very active in Division activities. Eleven clinical instructors and associate members also contribute to teaching in geriatrics in the lower mainland and on Vancouver Island.

Promotions in 2007 included Dr. Phil Lee as Assistant Professor (tenure track), Dr. Roger Wong to Clinical Associate Professor, and Dr. Janet Kushner-Kow to Clinical Assistant Professor.

The Division provides a wide range of clinical services across these sites, including active geriatric consultation services, in-patient acute care for elders (ACE), geriatric activation and assessment beds, geriatric day hospitals and multiple outpatient clinics. Most recently, the division has received approval for implementation of a team to deliver goal-responsive acute care for elders (GRACE). Clinical services provided as an outreach to the community are gradually being integrated into the Community Health Centers of VCH.

The Division’s strategic plan is moving forward and will continue to support and implement processes of care that improve outcomes of seniors accessing the acute care system with a specific focus on managing risk for functional decline through the transitions from care in the emergency department and acute care settings, back to the community. The Vancouver Initiative To Add Life to Years (VITALiTY) partnership continues to collaborate with other health disciplines within VCH and lead to an application to the Michael Smith Foundation for Health Research to formalize these relationships as a research team and establish an international network of collaborators. The Division’s major areas of research emphasis are in health services research and active research programs in diabetes, dementia, osteoporosis, falls prevention, cardiovascular disease, inflammation, immunosenescence and vaccination provide a foundation for the scholarship and service that will promote health, wellness and independence for seniors in the community of Vancouver Coastal Health and British Columbia.

Teaching

Undergraduate:

Dr. Kushner-Kow continues on the Undergraduate Education Committee overseeing the third year Internal Medicine Clerkship and its distribution to Victoria, Northern BC and the Fraser Valley. She is also Faculty Development Liaison for the third year committee, a Week chair for the Brain and Behaviour Block in year two, and organizer for the geriatrics component of the clinical skills course in year two.

Dr. Kushner-Kow developed and ran the 2007 Summer Institute in Geriatric Medicine, where 25 first and second year undergraduate students from medical schools across the country came to Vancouver in July 2007 to learn about and experience geriatrics as a career option. Highlights included panel discussions, small group learning, site visits and group activities. The Institute was co-sponsored by the Canadian Geriatrics Society and Divisions of Geriatric Medicine from the various medical schools.

Dr. Lee taught INDE 420 and provided clinical teaching through supervision of medical students on Geriatric Medicine and CTU. Other members of the division teach in various components of

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problem-based learning and clinical skills, as well as on the clinical teaching services in geriatrics and internal medicine.

Postgraduate

Dr. Kushner-Kow continues as Vice-chair for the Royal College Geriatric Medicine Examination Committee and has been involved in the transition to Standardized Clinical Examinations (StaCERs), a context-specific real-life evaluation method to ensure Geriatric Medicine trainees demonstrate clinical competencies. Geriatric Medicine is the first Specialty to adopt these StaCERS as part of their Royal College Assessment requirements.

Dr. Kushner-Kow also continues as the Program Director in Geriatric Medicine. The postgraduate program included two residents in 2007. We were highly successful in the 2008 subspecialty match, attracting three new trainees to start in July 2008. She helped to initiate a Geriatric Medicine Fellows Day which is to take place at the 2008 Canadian Geriatrics Society meeting in Montreal in April.

Dr. Roger Wong is Associate program director, postgraduate medical education, Department of Medicine UBC. He continues to champion the development of innovative curriculum and teaching methodologies for the department of Medicine.

All Division members continue to be actively involved in the teaching of internal medicine residents and fellows in the principles of the care of the frail elderly, including the clinical teaching units and noon rounds for medical residents.

Continuing Medical Education

Dr. Kushner-Kow continues to work with the UBC Care for Elders group, an interprofessional group dedicated to developing educational modules for interprofessional teams, as well as encouraging recruitment to the health professions dealing with working with Seniors. We are supported by the Strategic Teaching Initiative.

Dr. Kushner-Kow is an associate with the UBC Office of Faculty Development. She is developing and running the ACT (Advanced Clinical Teaching) course for mid-career faculty to improve their skills in medical education.

Dr. Kushner-Kow will take over as the CME director for the Canadian Geriatrics Society in January 2008.

Several members of the division continue to be active in CME including national and provincial initiatives in the areas of dementia, osteoporosis, cardiovascular fitness, and vaccination.

Research

Division members continue to develop their research programs. Dr. Meneilly continues his research program in diabetes in older adults and this has lead to a collaboration with Dr.

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McElhaney to study ‘inflammaging’ in older adults with diabetes and the metabolic syndrome, and its effect on immune function. Dr. Meneilly is also actively involved in the islet transplant program. Dr. Madden’s work with his CIHR funded project, a randomized, controlled trial of aerobic, strength to measure its effect on arterial stiffness and the cardiovascular control measures that prevent syncope during upright tilt is underway. Dr. Madden has also received a salary award from the Department of Medicine Academic Enhancement Fund.

Dr. McElhaney has established her research program on immunologic correlates of protection against influenza with CIHR funding for an international collaboration with European influenza vaccine developers, an industry-sponsored, investigator-initiated influenza vaccination study, a NIH U01 grant for work in Canada to develop improved influenza vaccines for older adults, and continued NIH funding under her R01 grant at the University of Connecticut.

Dr. Reva Adler is a geriatrician and public health specialist whose interests include the impact of ethnicity on ageing, the health challenges of older survivors of population-based violence such as genocide, and violence prevention research. Dr. Adler works with the Presidents Office and Senate of the Republic of Rwanda on a four-phase research initiative funded by the J. William Fulbright Scholarship Board of the US State Department , targeting primary prevention of ethnic violence in the Great Lakes region of Central Africa. In 2007, she was the lead author on two scholarly papers published reporting the results of Phase I of this research. Dr. Adler is a member of the invitation-only Global Futures Forum, a joint initiative of the U.S. State Department and the Privy Council of Canada; the group meets semi-annually to discuss and develop interdisciplinary initiatives designed to prevent catastrophic violence worldwide. In 2007-2008, Dr. Adler launched the BCD-E research initiative in West Darfur, a program designed to identify and support the conflict-related mental health sequelae and treatment needs of average citizens in the Darfur region of Sudan. Dr. Adler is also the principal investigator for the ongoing research "Newer Older Immigrants to Vancouver", a study designed to identify the health services needs of older Chinese and South Asian immigrants to the lower mainland of British Columbia.

Dr. Roger Wong continues to conduct research in acute care service delivery for older adults, and in medical education with the development of new curriculum to enhance competency in quality improvement, health advocacy, and communication among internal medicine residents.

Dr. Beattie is involved in multiple research projects related to dementia and is Chair of the Research Policy Committee for the Alzheimer Society of Canada and the BC Network for Aging Research, a member of the CIHR Gender, Sex and Health Committee, and Acting Director, Centre for Health Aging at Providence.

Dr. Hill is involved in interventions and health care delivery research in the areas of management of congestive heart failure and delirium, and has developed a pre-printed order set for the management of delirium. In this next year, the Division will set up a peer-mentoring group to promote collaboration within the Division and to integrate our research expertise with others in the health research community.

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Dr Alimoradi has been enrolled in a Masters in Healthcare and Epidemiology (MHSc) at UBC on a full time basis. This program is for individuals with MD or PhD degrees who would like to learn research methods systematically.

Dr. Lee had a first author publication in Journal of Clinical Epidemiology, co-authored publication in Annals of Internal Medicine, and co-authored chapter in Atlas of Alzheimer's disease.

Clinical Services

At both PHC and VA, clinical activities continue to increase. At VGH, ACE units continue to operate at maximum capacity of 69 beds. Approval for the GRACE team at St. Paul’s Hospital will introduce a model of interprofessional collaborative practice in achieving patient-centered goals of care, with training opportunities for all health care disciplines. The Division is actively involved in patient assessment and management at the VGH STAT Centre, which moved into the newly renovated Centennial Pavilion.

A collaboration between VGH and PHC has extended geriatric outreach network to most of the Community Health Centers within Vancouver Community Health and is working on initiatives the will strengthen the collaboration between primary, community and acute care. This will include initiatives such as the Frail Elderly Collaborative project lead by Dr. Chris Rauscher as a provincial initiative.

Dr. Chris Rauscher works with the Three-Bridges Community Health Centre providing consultation support to the Adult/Older Adult program of VCH Vancouver Community Health Services. Dr. Rauscher also works as a “clinical quality improvement advisor” working throughout BC with the Ministry of Health and Vancouver Coastal Health.

Drs. Dian, Kushner-Kow, Madden and Malone are part of the Geriatrics Outreach Teams to Northern BC. They provide specialized Geriatric Medicine consultation services to Northern, rural and remote communities including Queen Charlotte City, Masset, Prince Rupert, Terrace, Kitimat, Smithers, Burns Lake, Vanderhoof, Fraser Lake, McBride, Dawson Creek, Fort St John and Fort Nelson. This unique model of care involves Geriatric Medicine specialists pairing with Geriatric Psychiatrists, visiting communities on a regular basis and working in tandem with community service providers in those towns.

Dr. Alimoradi has been working at geriatric outpatient clinic and geriatric day hospital at SPH and geriatric outreach at North Community Health Center, also providing internal medicine/geriatric consultation to Holy Family Hospital. Dr. Alimoradi has been working in the SPH falls clinic founded by Dr. Wendy Cook and helped in the development of the assessment form.

Dr. Lee performed clinical services in Geriatric Medicine, St. Paul's Hospital, the Alzheimer's and Related Disorders Clinic at UBC Hospital, and the Clinical Teaching Unit at St. Paul's Hospital

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Administration

Dr. Janet McElhaney continues as the Head, Division of Geriatric Medicine for both UBC and PHC, and the PHC Physician Program Co-Director for Elder Care with responsibilities at three PHC sites for geriatric and rehabilitation medicine, and will also include geropsychiatry. She is also the Regional Medical Director for the Seniors Population Continuum for Vancouver Coastal Health.

At VA, Dr. Meneilly is Chair of the Department of Medicine at both VA and UBC.

Dr. Larry Dian is the VA Division Head for Geriatric Medicine.

Dr. Janice Menezes is the Physician Operations Leader at St. Paul’s.

Dr. Reva Adler is Medical Director of the VGH STAT Centre.

Dr. Amanda Hill continues in her role as Medical Director, Community and Specialty Medicine.

Dr. Roger Wong continues his roles as Medical Director, Geriatric Consultation Program and Medical Manager, ACE units at VA.

Dr. Maria Chung is Medical Director, UBC Hospital.

Special Honours and Awards

Dr. Roger Wong was elected as the Secretary-Treasurer, Canadian Geriatrics Society. He received the 2007 UBC Killam Teaching Prize, one of the most prestigious teaching awards to faculty in recognition of excellence in teaching. He also received the 2007 Donald Richards Wilson award from the Royal College of Physicians and Surgeons of Canada in recognition of excellence in integrating the CanMEDS roles into training programs.

Dr. Lee was recognized with the St. Paul's Hospital Foundation Physician Scholar Award, UBC Academic Enhancement Fund 2007, and the Cullen Research Institute, Centre for Healthy Aging at Providence Award.

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HEMATOLOGY

Dr. Michael Barnett Clinical Professor & Head

Faculty Members Professor Humphries, Dr. Richard Keith BCCA Professor Lansdorp, Dr. Peter BCCA Professor Schrader, Dr. John VA Associate Professor Smith, Dr. Clayton VA Clinical Professor Ballem, Dr. Penny Clinical Professor Barnett, Dr. Michael VA/BCCA Clinical Professor Hogge, Dr. Donna VA/BCCA Clinical Professor Nevill, Dr. Thomas VA/BCCA Clinical Professor Vickars, Dr. Linda SPH Clinical Associate Professor Benny, Dr. W. VA Clinical Associate Professor Forrest, Dr. Donna VA/BCCA Clinical Associate Professor Nantel, Dr. Stephen VA/BCCA Clinical Associate Professor Shepherd, Dr. John VA/BCCA Clinical Associate Professor Sutherland, Dr. Heather VA/BCCA Clinical Associate Professor Toze, Dr. Cynthia VA/BCCA Clinical Assistant Professor Broady, Dr. Raewyn VA Clinical Assistant Professor Leger, Dr. Chantal SPH Clinical Assistant Professor Leitch, Dr. Heather SPH Clinical Assistant Professor Li, Dr. Charles SPH Clinical Assistant Professor Song, Dr. Kevin VA Clinical Assistant Professor Sreenivasan, Dr. Gayatri VA Clinical Assistant Professor Tsang, Dr. Peter VA Clinical Instructor Foltz, Dr. Lynda New Westminster Clinical Instructor Galbraith, Dr. Paul SPH Clinical Instructor Lavoie, Dr. Julye VA Clinical Instructor Petraszko, Dr. Tanya VA Clinical Instructor Ramadan, Dr. Khaled SPH Clinical Instructor Zypchen, Dr. Leslie VA Associate Member Coupland, Dr. Robert VA Associate Member Eaves, Dr. Connie BCCA Associate Member Horsman, Dr. Douglas BCCA Clinical Professor (Emeritus) Buskard, Dr. Noel VA

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Divisional Overview

The UBC Division of Hematology includes 29 staff and 3 associate staff members based at the Vancouver General Hospital (VGH), the Vancouver Cancer Centre (VCC) and the Terry Fox Laboratory (TFL) of the British Columbia Cancer Agency, St. Paul’s Hospital (SPH), and University of British Columbia (UBC). In 2007, laboratory research programs at TFL and UBC achieved peer-reviewed operating support of $1.2 million and CFI equipment funds of $153,000 and clinical research at VGH and SPH brought in $1 million. There was a total of 58 peer- reviewed publications. Patient care and training remained at the forefront of clinical activities. Trainees in the Division as a whole included 5 Hematology residents, 7 Leukemia/BMT fellows, 13 laboratory post-doctoral fellows and 9 graduate students.

Teaching

Undergraduate: This was the 9th year of the Blood & Lymphatics Block in the Problem Based Learning course.

Postgraduate: A total of 25 Residents in the Internal Medicine Program took hematology-based electives during the past year. These were one or two month blocks spent on the Hematology Consultation Service at VGH or SPH.

Subspecialty Training: Five General Hematology residents were based at VGH. Rotations included the General Hematology Consultation Service, Leukemia/BMT Service, Blood Transfusion Service, Cell Separator Unit, Out-patient Clinics and Hematopathology. Rotations were also taken at SPH, VCC, BC Women’s and Children’s Hospital. These positions were filled by Drs. Zayed Al-Zahrani (July 1, 2007), Luke Chen, Hatoon Ezzat, Jesse Shustik (July 1, 2006) and Paul Yenson (July 1, 2005 to June 30, 2007). In the autumn, Dr. Yenson began fellowship training in apheresis (Puget Sound Blood Center, Seattle) to be followed by hemophilia/hemoglobinopathies (Hospital for Sick Children, Toronto and Hemoglobinopathy Reference Laboratory, Hamilton). Dr. Carolyn Owen continued a research fellowship at Centre for Medical Oncology, St. Bartholomew’s Hospital, London.

Leukemia/Bone Marrow Transplantation Fellowship: The Leukemia/BMT Program had seven positions available for clinical training in the management of patients with hematological malignancies and those undergoing hematopoietic stem cell transplantation. These positions were filled by Drs. Satish Anumula, William Han, Jonathan Hebb, Kai Luecke, Manoranjan Mahapatra, Sujaatha Narayanan and Lakshmi Pillai.

Postdoctoral Training: Division Members conducting bench research at the TFL and UBC trained 3 postdoctoral fellows, all of whom were PhDs.

Doctoral Training: The Terry Fox Lab accommodated 6 graduate students and 19 research and co-op students.

Continuing Medical Education: Division Members attended numerous national and international meetings both as speakers and attendees.

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Research Clinical research involved hematological malignancies, hematopoietic stem cell transplantation, apheresis, thrombosis, iron overload and HIV/AIDS. As well as in-house studies, significant contributions were made to national and international trials. Collaborative research in graft versus host disease was conducted at the Jack Bell Research Centre. Laboratory research based at the TFL involved the regulation of normal and malignant hematopoietic cell growth and differentiation with special emphasis on the myeloid leukemias, Hox genes and telomeres. The molecular characterization of regulatory pathways was the focus at UBC.

Clinical Services The clinical services at VGH and SPH continued to cope with a high workload in terms of both inpatient and outpatient activities.

Dr. Paul Galbraith joined the staff of the Fraser Valley Cancer Centre after 12 years of sterling service at SPH. Dr. Lynda Foltz was appointed as a staff hematologist at SPH. Dr. Maryse Power joined the senior staff of the Leukemia/BMT Program at VGH/VCC. Dr. Sujaatha Narayanan took a locum position in the Leukemia/BMT Program to cover Dr. Julye Lavoie’s maternity leave.

The out-patient activity (Daycare and Clinics) of the Leukemia/BMT and General Hematology groups as well as the Cell Separator Unit at VGH were relocated to CP6, Centennial Pavilion.

Administration Dr. Michael Barnett became Head of Hematology at SPH. Dr. Linda Vickars (Medical Director of the Adult Hemophilia and Hemosiderosis Programs at SPH), Dr. Clayton Smith (Director of the Leukemia/BMT Program at VGH and VCC), Dr. Stephen Nantel (Director of the Clinical Practice Unit for Hematology/BMT at VGH), Dr. Barrett Benny (Director of the Cell Separator Unit at VGH) and Dr. Peter Tsang (Head of General Hematology at VGH & Director of the Hematology Training Program) continued in leadership positions.

Future Directions The major initiatives over the next few years will be to:

• Sustain a Hematology Clinical Trials Unit (established with donated funds in 2005) • Enhance translational research in hematological malignancies and stem cell transplantation • Establish a clinical research group in thrombosis • Improve collaborations with the Centre for Blood Research at UBC • Develop a comprehensive Provincial Hemophilia & Hemoglobinopathy Program • Create fellowships in areas other than Leukemia/BMT • Unify the VGH/VCC and SPH components of the Division

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Special Honours and Awards

Dr. Keith Humphries Completed term as President of the International Society of Experimental Hematology.

Dr. Peter Lansdorp Awarded the UBC Killam Research Prize in the Science category

Dr. Stephen Nantel Appointed Chair of the Medical Advisory Committee forVancouver Acute.

Dr. John Shepherd Recipient of the inaugural BC Patient Safety Leadership Award

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INFECTIOUS DISEASES

Dr. Neil E Reiner Professor & Head

Dr. H Grant Stiver Professor & Assistant Head

Dr. Mark Tyndall Associate Professor & Head St. Paul’s Division of Infectious Diseases

Faculty Members

Professor Bowie, Dr. William VA Professor Brunham, Dr. Robert BCCDC Professor Reiner, Dr. Neil VA Professor Stiver, Dr. H. VA Associate Professor Av-Gay, Dr. Yossef VA Associate Professor Tyndall, Dr. Mark SPH Assistant Professor Cherkasov, Dr. Artem VA Assistant Professor de Haan, Dr. Marie VA Assistant Professor Harrigan, Dr. Paul SPH Assistant Professor Hmama, Dr. Zakaria VGH Assistant Professor Kerr, Dr. Thomas SPH Assistant Professor Nandan, Dr. Devki VA Assistant Professor Steiner, Dr. Theodore VA Clinical Professor Burdge, Dr. David BCW Clinical Professor Phillips, Dr. Peter SPH Clinical Professor Rekart, Dr. Michael BCCDC Clinical Assistant Professor Montessori, Dr. Valentina SPH Clinical Assistant Professor Moore, Dr. David SPH Clinical Assistant Professor Pick, Dr. Neora BCW Clinical Assistant Professor Press, Dr. Natasha SPH Clinical Assistant Professor Reynolds, Dr. Robert VA Clinical Assistant Professor Wood, Dr. Evan SPH Clinical Instructor Mirzanejad, Dr. Yazdan SMH Adjunct Professor Grigg, Dr. Michael VA

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Associate Member McElhaney, Dr. Janet SPH/VA Associate Member Isaac-Renton, Dr. Judith BCCDC Associate Member Jewesson, Dr. Peter Associate Member Marra, Dr. Fawziah BCCDC Associate Member McMaster, Dr. W. Robert C&W Health Centre Associate Member Money, Dr. Deborah BCW Associate Member Patrick, Dr. David BCCDC Professor (Emeritus) Chow, Dr. Anthony VA Clinical Professor (Emeritus) Chan, Dr. Robert SPH

Divisional Overview

The Division of Infectious Diseases continued to be productively engaged with patient care, education and research activities at three teaching hospitals located at Vancouver General (VGH), St. Paul’s (SPH) and BC Children’s & Women’s Hospitals, and at the BC Centre for Disease Control. The growth and achievements of the previous years have produced not unexpected challenges in terms of infrastructure and resources. Efforts continue to recruit new clinician scientists to replace a retired senior faculty member and an Infectious Diseases Transplant Specialist to become Director of a BC Transplant and Immunocompromised Host in Infectious Diseases Program. A critical priority involved planning with Vancouver Coastal Health and the Faculty of Medicine to obtain funding for new space for the Division which must be available within the next two years.

Teaching

Teaching has been a major strength of the Division of Infectious Diseases (ID). Faculty make substantial contributions to teaching undergraduate and postgraduate students, residents and fellows from the Faculty of Medicine. This includes teaching 14 visiting medical students and residents from other Canadian medical schools who came to Vancouver for electives in Infectious Diseases at VGH and SPH.

Undergraduate: The Division’s significant commitment to medical undergraduate teaching includes the highly regarded Host Defense Infection Block in the Problem Based Learning course. Dr. Mark Tyndall is the Week Chair for HIV/AIDS. Dr. Grant Stiver continues to be Program as Director of Undergraduate Education for the Faculty of Medicine, and Dr Bill Bowie is the Undergraduate Education Supervisor for the Division of Infectious Diseases. Training in basic science in the Immunity and Infection research labs at VGH is popular, attracting science co-op students from a variety of institutions in BC.

Postgraduate: Under the very effective leadership of Dr Natasha Press as Program Director of the ID Residency Training Program, inpatient and outpatient training was provided to 51 residents from Medicine and Surgery programs at St. Paul’s and Vancouver General Hospital. The ID Subspecialty Training Program continues to provide high quality clinical and research training to prepare residents for a career as infectious diseases specialists. A total of 6 subspecialty residents and clinical fellows participated in the two year Infectious Diseases training program. Research

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Faculty supervised 9 Post Doctoral Fellows in either laboratory research at VGH, or in clinical research at St. Paul’s Hospital.

Graduate Students: Infectious Diseases Faculty supervised at least l5 graduate students during the year. The students are primarily affiliated with the Experimental Medicine Program, Health Care and Epidemiology, Laboratory Medicine and Microbiology and Immunology, and Medical Genetics.

CIHR Strategic Training Program for Translational Research in Infectious Diseases (TRID): TRID is directed by Dr. Mark Tyndall and is an important source for student participation in the Division. The TRID program is specifically designed to engage and train young research scientists in the methods of translational research through expert mentorship, a weekly lecture series, and trans-disciplinary seminars. The intake of 15-20 undergraduates occurs three times each year and there are 8-10 Master’s and PhD positions that are funded for the duration of their post-graduate program.

Research

Research programs being conducted at all four principal sites of the Division are diverse and broad-based as detailed below. The Division’s research programs are highly productive and innovative, resulting in grant funding totaling $ 5.6 M during 2007. Research funding comes from multiple sources including CIHR, Genome Canada and the NIH amongst others.

Host defense and pathogenesis: The Division maintains an active basic research program in molecular microbial pathogenesis and host defense at VGH. Pathogens under study included M. tuberculosis, Leishmania, E. coli, Staphylococci, Streptococci and Chlamydia. In addition to addressing mechanisms of pathogenesis, ongoing research is concerned with both innate and acquired immune responses to infection including vaccine development. The Division’s research program has an important bioinformatics focus with additional state-of-the art expertise in molecular modeling and computer-aided drug design.

HIV/AIDS Research Program: The AIDS Research Program conducted through the BC Centre foe Excellence in HIV/AIDS, involves faculty members at the St. Paul’s site. It is nationally and internationally recognized for work in all facets of HIV, including behavioral studies, epidemiology, clinical trials and basic sciences. The epidemiology group has been actively developing and maintaining long-term analyses of drug treatment programs in Vancouver, including harm reduction strategies to prevent HIV transmission. Recent clinical research has been launched into HIV co-infections with Hepatitis C and Human Papilloma Virus.

Epidemiological Research: The wide ranging research of ID Faculty at the UBC CDC includes STD prevention, control and service delivery; control of emerging infectious diseases; assessment of the human papillomavirus infection (HPV); reduction of antimicrobial misuse as linked to the emergence of resistant organisms; detection and description of unique outbreaks such as Cryptococcus gattei disease;

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and early interruption of transmission of diseases from infected food products. Drs. Michael Rekart and Bill Bowie continue their work with CIDA funded projects concerning STD, HIV, TB prevention and care in Vietnam, and ecosystem health in Ecuador.

Clinical Research: Dr. Bill Bowie is a co-Principal Investigator on a VCHRI project headed by Steven Reynolds, a Post Doctoral Fellow from Intensive Care, to study management of patients with cutaneous abscesses (which will largely be due to community acquired MRSA) presenting to the VGH Emergency Room (Placebo controlled evaluation of incision and drainage alone vs. incision and drainage plus trimethoprim-sulfamethoxazole and rifampin). The Oak Tree Program at Children’s and Women’s Health Centre of BC has a collaborative clinical research program led by Dr David Burdge which focuses on women/gender issues in HIV with clinical studies in HIV infected women, pregnant women and children. Dr Grant Stiver was principal investigator in a study: ”Immune response and the kinetics and persistence of antibody to influenza vaccination in health care workers”, collaborating with the BCCDC. Dr. Mark Tyndall is the Principal Investigator of the Vancouver site for the STEP study which is a multinational study of a preventative HIV vaccine.

Clinical Services

The Division maintains two highly active consultation services at SPH and at VGH. The complexity and number of consultations continues to be challenging, particularly with ongoing recruitment needs for clinical faculty at both hospitals. The consultation services see the usual full range of general ID cases, but additionally, there is increasing demand to treat infections in reconstructive orthopedics including spine, neurosurgery, bone marrow and solid organ transplant, tuberculosis, infections related to IVDU and infections in other marginalized populations. The AIDS inpatient ward based at SPH continues to be extremely busy.

Administration

The formation of the Division of AIDS, with J. Montaner as Head, was approved by the Department of Medicine Executive Committee in April. Four faculty members transferred from ID Division to the AIDS Division including R. Harrigan, T Kerr, J Montaner, and E Wood. A number of ID Faculty became associate members of the AIDS Division.

Members of the Division involved in expert committees included:

Yossef Av-Gay • Member of the scientific review panel of the European Commission; 7th Framework Infectious Diseases • Member of the Canadian Institute if Health Research (CIHR) “China-Canada Joint Health Research Initiative” Committee.

William Bowie • Member of the Provincial Infection Control Network (PICNet)

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• Member of Health Canada Veterinary Drugs Directorate Expert Advisory Committee on Antimicrobial Resistance Risk Assessment • Member of the Tick-borne disease committee of the Health Canada National Non Enteric Zoonotic Diseases Committee

Tony Chow • Canadian Institute of Academic Medicine Expert Advisory Board on Anti-Infective Therapies, Therapeutic Products Directorate, Health Canada • CIHR University-Industry Peer Review Committee • Co-Chair, Infectious Disease Society of America Clinical Practice Guideline Committee on Sinusitis

Neil Reiner • Member, Canadian Institutes of Health Research peer review panel for Proof of Principle (POP) Program • Elected to Council, Society for Leukocyte Biology, Chair Meetings Committee, Society for Leukocyte Biology

Ted Steiner • CIHR Experimental Medicine peer review panel

Grant Stiver • Co-chaired the Clinical Care Working Group for the Public Health Agency of Canada (PHAC) Pandemic Influenza Committee • Member of the PHAC Expert Task Group on Oseltamivir Resistance regarding the impact of oseltamivir resistance on pandemic influenza management • Member of the Canadian Council of Academies Committee on Influenza Transmission and Personal Protective Respiratory Equipment (Commissioned by PHAC)

Mark Tyndall • Executive Secretary for the Canadian Association for HIV Research CAHR) • Member of the Reference Group to the UN on HIV and Injection Drug Use • Temporary Consultant - WHO Working Group on Tuberculosis and Injection Drug Use • CIHR peer review panel for Gender, Sex and Health

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MEDICAL ONCOLOGY

Dr. Susan E. O'Reilly Professor & Head

Faculty Members

Clinical Professor & Head O'Reilly, Dr. Susan BCCA/Vancouver Clinical Professor & Acting Head Connors, Dr. Joseph BCCA/Vancouver Assistant Professor Chi, Dr. Kim BCCA/Vancouver Assistant Professor Chia, Dr. Stephen BCCA/Vancouver Assistant Professor Gill, Dr. Sharlene VA Assistant Professor Savage, Dr. Kerry VA Clinical Professor Gelmon, Dr. Karen BCCA/Vancouver Clinical Professor Hoskins, Dr. Paul BCCA/Vancouver Clinical Professor MacLean, Dr. Grant BCCA/Victoria Clinical Professor Murray, Dr. Robert Nevin BCCA/Vancouver Clinical Professor Shah, Dr. Amil BCCA/Vancouver Clinical Professor Swenerton, Dr. Kenneth BCCA/Vancouver Clinical Professor Weinerman, Dr. Brian BCCA/Victoria Clinical Associate Professor Coppin, Dr. Christopher BCCA/Fraser Valley Clinical Associate Professor Klasa, Dr. Richard BCCA/Vancouver Clinical Associate Professor Klimo, Dr. Paul Lion’s Gate Hospital Clinical Associate Professor Ragaz, Dr. Joseph BCCA Clinical Associate Professor Wilson, Dr. Kenneth BCCA/Victoria Clinical Assistant Professor Allan, Dr. Sharon BCCA/Victoria Clinical Assistant Professor Anderson, Dr. Helen Victoria Clinical Assistant Professor Bernstein, Dr. Vanessa BCCA/Victoria Clinical Assistant Professor Bryce, Dr. Cicely BCCA/Vancouver Clinical Assistant Professor Gill, Dr. Karamjit Surrey Clinical Assistant Professor Khoo, Dr. Kong BCCA/Kelowna Clinical Assistant Professor Knowling, Dr. Margaret (Meg) BCCA/Fraser Valley Clinical Assistant Professor Laskin, Dr. Janessa BCCA Clinical Assistant Professor Lee, Dr. Ursula BCCA/Fraser Valley Clinical Assistant Professor MacPherson, Dr. Nicol BCCA/Victoria Clinical Assistant Professor Melosky, Dr. Barbara BCCA/Vancouver Clinical Assistant Professor Noble, Dr. R. RCH

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Clinical Assistant Professor Norris, Dr. Brian BCCA/Fraser Valley Clinical Assistant Professor Sawhney, Dr. Ravinder BCCA/Fraser Valley Clinical Assistant Professor Sehn, Dr. Laurie BCCA/Vancouver Clinical Assistant Professor Shenkier, Dr. Tamara BCCA/Vancouver Clinical Assistant Professor Stuart, Dr. David Burnaby Clinical Assistant Professor Taylor, Dr. Marianne BCCA/Victoria Clinical Instructor Bouttell, Dr. Elaine Kelowna Clinical Instructor Ellard, Dr. Susan VA Clinical Instructor Fenton, Dr. David BCCA/Kelowna Clinical Instructor Fitzgerald, Dr Catherine BCCA/Victoria Clinical Instructor Lee, Dr. Christopher BCCA/Fraser Valley Clinical Instructor MacNeil, Dr. Mary BCCA/Victoria Clinical Instructor Martin, Dr. Lee Ann BCCA/Fraser Valley Clinical Instructor Martins, Dr. Heidi BCCA/Victoria Clinical Instructor Souliere, Dr. Sheila Victoria Clinical Instructor Sutherland, Dr. Judith BCCA/Kelowna Honorary Professor Bruchovsky, Dr. Nicholas BCCA/Emeritus Associate Member Brigden, Dr. Malcolm Victoria Associate Member Ling, Dr. Victor BCCRC Clinical Professor (Emeritus) Goldie, Dr. James BCCA/Emeritus Clinical Professor (Emeritus) Klaassen, Dr. David BCCA/Emeritus Clinical Professor (Emeritus) Plenderleith, Dr. Ian BCCA/Emeritus Clinical Professor (Emeritus) Silver, Dr. Hulbert BCCA/Emeritus

Divisional Overview

The Division of Medical Oncology, UBC, comprises the medical oncology and scientific staff at the Vancouver Center, Fraser Valley Center, Surrey, Vancouver Island Center, Victoria and the Center for the Southern Interior, Kelowna, as well as community oncologists in Burnaby, North Vancouver, Nanaimo and the Royal Columbian Hospital, New Westminster.

In addition to the clinical division, there is a laboratory section (Advanced Therapeutics), which is located in the British Columbia Cancer Research Center. It comprises four senior scientists and six clinical investigators who have appointments at the Vancouver Cancer Center, Department of Medical Oncology.

Medical Oncology clinical services are organized as a Provincial Systemic Therapy Program reaching across the Province of British Columbia including the four cancer centers and outreach programs in more than twenty additional community hospitals in smaller urban centers. Undergraduate teaching occurs in the Vancouver, Victoria and Fraser Valley Cancer centers. Postgraduate teaching occurs primarily at the Vancouver Cancer Center with additional elective opportunities available at all four cancer centers including Victoria, Fraser Valley and Kelowna. UBC clinical faculty at all centers participate in undergraduate teaching modules.

The next five years will pose some exciting challenges and opportunities. More medical oncologists and hematologists specializing in neoplastic diseases will be recruited to address the

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rising incidence of cancer, related to the aging population and, even more importantly, the increasingly complex treatment programs incorporating new targeted small molecules and immunotherapeutic agents. Expanded opportunities for clinical and translational research is readily available based on the rapid emergence of new knowledge in cancer biology, especially insights derived from molecular oncology, genomic and gene expression studies.

The new $100,000,000 B.C. Cancer Research Center building opened in early 2005. This state- of-the-art research facility houses a wide range of laboratory research programs including molecular oncology, the Terry Fox Laboratory focusing on hematologic cellular biology and leukemias and core programs in genomic analysis, gene expression profiling, novel imaging and tumor modeling and population based epidemiology and biostatics. The BC Cancer Agency Genome Sciences Centre has moved into a large laboratory facility nearby but continues to forge collaborative projects with several tumor groups within Medical Oncology including breast cancer, gastrointestinal cancer and lymphoproliferative neoplasms.

Major changes are underway for Medical Oncology. After 13 years of highly successful leadership Dr Susan O’Reilly is stepping aside as division chair to assume additional responsibilities within her portfolio as Vice President Cancer Care. Dr O’Reilly can look back on a period of extraordinary growth and productivity for the Division of Medical Oncology at BCCA. She led the division through the opening or expansion of the Fraser Valley Cancer Centre in Surrey and the Centre for the Southern Interior in Kelowna. She has had a pivotal leadership role in the planning of the new centre soon to be opened in Abbotsford and has been at BCCA’s point person exploring the challenges of providing enhanced cancer care in the northern areas of the province including the possibility of opening a centre in Prince George. A whole generation of future leaders in Medical Oncology for BC and Canada have been recruited to join the staff at BCCA by Dr O’Reilly. Her leadership style combining high expectations and strong personal support has ensured international recognition and a prominent national leadership role for Medical Oncology at BCCA

The Division of Medical Oncology is delighted to have been able to recruit Dr Charles Blanke to be the new Divisional Head starting in April 2008. Dr Blanke brings extensive experience leading clinical research in the area of gastrointestinal cancers and a comprehensive understanding of the challenges facing the delivery of systemic care for cancer patients in an era of targeted therapy and explosive expansion of our understanding of fundamental cancer biology. His arrival promises to bring new perspectives and excitement to the division and his recruitment is an appropriate final contribution by Dr O’Reilly from her tenure as Divisional Head.

Teaching

The Medical Oncology Undergraduate Training Committee, chaired by Dr. Amil Shah is active in providing and planning teaching modules and clinical bedside teaching in Internal Medicine. An elective in Medical Oncology is available to UBC and visiting medical students.

The Postgraduate Training Committee, chaired by Dr. Tamara Shenkier, offers popular two- month electives in Medical Oncology to internal medicine residents from UBC and other universities. Approximately 10-16 residents per year from these and other specialty disciplines

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spend elective periods at the Vancouver Cancer Center. Opportunities are available for electives at all of our regional cancer centers and some financial support for travel and accommodation is available for residents choosing one of these options.

The Postgraduate Training Committee also plans and supervises the two-year subspecialty- training program in Medical Oncology. This program is based at the Vancouver Cancer Center with elective opportunities at all other centers and in community oncology practice. The four- month elective period may also be applied to laboratory or clinical research. One or two month electives at centers elsewhere in Canada or in other countries may also be considered. This program, now one of the largest programs in Canada, has expanded to enroll four first year and four second year residents and is fully approved by the Royal College of Physicians and Surgeons of Canada and has consistently received excellent reviews. Additional training positions for overseas residents result in eight or nine trainees participating in this two-year program at any one time. Currently, residents participate in academic oncology training with excellent exposure to clinical practice, ambulatory care and clinical trials. Residents are expected to conduct clinical research and have a number of publications and presentations to their credit. At least half of our residents from each year recently have competed successfully for post-residency academic subspecialty fellowships that have launched them on promising academic careers. Opportunities to pursue laboratory research projects are available.

Continuing Medical Education

All medical staff are active in continuing medical education courses organized by the British Columbia Cancer Agency, other provincial, national and international bodies. Several of our faculty members have emerged as international leaders in their field and are actively sought out to provide leadership within the major international societies including the American Society of Clinical Oncology, the American Society of Hematology and the American Association for Cancer Research in addition to their contributions to the National Cancer Institute of Canada and its Clinical Trials Group.

Research

Members of the Division are involved in a wide variety of phase I, II, III and IV clinical trials. These include the development of new anti-cancer drugs, the evaluation of new doses schedules and combinations of drugs in the phase II setting and the participation in multi-institutional phase III studies and post marketing phase IV trials evaluating effective new treatments on specific categories of malignancy.

Our phase I investigational new drug program has grown rapidly as a reflection of the energy and enthusiasm of the scientists and physicians in the Advanced Therapeutics section of Medical Oncology and in response to the increasing availability of new agents for testing in North America. We are currently expanding clinical and translational research in a new unit at the Vancouver Cancer Centre.

Our Advanced Therapeutics section is able to evaluate new biological response modifiers, gene therapy and pharmaceutical agents through all stages from in-vitro testing in the laboratory to

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evaluation in human volunteers. The Vancouver Cancer Center has the only Clean Room in an academic center in Canada that is equipped and licensed for the packaging and formulation of pharmaceutical agents in small quantities for clinical testing.

At the pre-clinical level, studies are being carried out in evaluating anti-angiogenesis agents, gene modifiers, enzyme inhibitors, experimental drug modulators, pre-clinical drug toxicities and molecularly targeted agents such as the new tyrosine kinase inhibitors, immunotherapeutic agents targeted against breast cancer, colorectal cancer, lung cancer and lymphomas.

Currently, our oncologist’s partner with scientists, pathologists and epidemiologists in winning research grants for collaborative population-based and translational research the BCCA manages its own grants and these are not listed in this report.

Clinical Services

The four B.C. Cancer Centers now provide medical oncology consultations for 9,000 new patients annually with more than 62,000 ambulatory care visits to these centers.

Administration

The Provincial Systemic Therapy Program, headed by Dr. Susan O’Reilly manages the $100,000,000 oncology drug budget, which supports the care of more than 26,000 patients annually, both within BCCA centers and in community hospitals and plans and delivers clinical services in BCCA Centers. Opportunities for health services research projects are available and linkages with the Provincial Tumour Registry and Vital Statistics are readily available. We are uniquely positioned to further develop province-wide population-based research in health outcomes for cancer patients and regularly take advantage of this special opportunity.

Future Directions

The major academic goal of the Division is to continue to build an outstanding translational research unit that combines the excellent basic science research at the British Columbia Research Center, the input from the Genome Science Centre, the resources of our academic medical oncologists and the participation of our large patient population.

British Columbia has consistently shown the best cancer survival statistics in Canada and we are in a unique position to carry out province-wide treatment programs in both clinical and translational research. We are continuously expanding our research agenda in these areas and in those of health outcomes and economic analyses.

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NEPHROLOGY

Dr. Paul Keown Professor & Head

Faculty Members

Professor Keown, Dr. Paul VA Professor Quamme, Dr. Gary VA Professor Wong, Dr. Norman VA Assistant Professor Gill, Dr. John SPH Clinical Professor Chan-Yan, Dr. Clifford SPH Clinical Professor Levin, Dr. Adeera SPH Clinical Professor Werb, Dr. Ronald SPH Clinical Associate Professor Landsberg, Dr. David SPH Clinical Associate Professor Shapiro, Dr. Jean VA Clinical Associate Professor Taylor, Dr. Paul SPH Clinical Associate Professor Yeung, Dr. Choi Kit VA Clinical Assistant Professor Cass, Dr. Aaron Surrey Clinical Assistant Professor Chiu, Dr. Anthony SPH Clinical Assistant Professor Copland, Dr. Michael VA Clinical Assistant Professor Da Roza, Dr. Gerald New Westminster Clinical Assistant Professor De Luca, Dr. Linda SPH Clinical Assistant Professor Duncan, Dr. John VA Clinical Assistant Professor Jastrzebski, Dr. Jacek VA Clinical Assistant Professor Karim, Dr. Mohamud Surrey Clinical Assistant Professor Kiaii, Dr. Mercedeh SPH Clinical Assistant Professor Neufeld, Dr. Peter VA Clinical Assistant Professor Singh, Dr. Rajinder VGH Clinical Assistant Professor Zalunardo, Dr. Nadia VA Clinical Instructor Jamal, Dr. Abeed SPH Clinical Instructor Jung, Dr. Beverly SPH Professor (Emeritus) Price, Dr. John Professor (Emeritus) Sutton, Dr. Roger VA Associate Professor (Emeritus) Cameron, Dr. Eugene VA Clinical Professor (Emeritus) Rae, Dr. Angus Clinical Assoc Prof (Emeritus) Chan, Dr. Victor Royal Columbian

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Associate Members

Clinical Associate Professor Victor Chan Retired (Emeritus) Clinical Assistant Professor Aaron Cass Royal Columbian, New Westminster Clinical Assistant Professor Gerald Da Roza Royal Columbian, New Westminster Clinical Assistant Professor Friesen Royal Columbian, New Westminster Clinical Assistant Professor Gaylene Hargrove Royal Jubilee, Victoria Clinical Assistant Professor Christopher Jones Royal Jubilee, Victoria Clinical Assistant Professor / Mohamud Karim Royal Columbian, New Westminster Med. Director (Renal) Clinical Assistant Professor George Lam Royal Columbian, New Westminster Professor (grant tenure) Alex Magil St. Paul's Hospital Clinical Assistant Professor Daniel Schwartz Abbotsford Regional Hospital / Cancer Centre

In October 2007, the University’s Board of Governors approved the promotion of Dr. John Gill to Associate Professor (Grant Tenure) after periodic review. We congratulate Dr. Gill on this tremendous achievement.

Divisional Overview

The Division of Nephrology includes 22 current members based at three principal sites: St. Paul’s Hospital, Vancouver General Hospital, and UBC Hospital, who provide provincial leadership in research, education, and clinical care within the field of renal medicine. The Division also welcomed 4 new associate members in 2007, for a total of 10, representing the Fraser and Vancouver Island Health authorities, as a result of the expanded presence of the distributed Medical Program of the Faculty of Medicine across BC. The Division has a strong clinical base and provides integrated and decentralized nephrology care throughout Vancouver Coastal Health, including Richmond, North Vancouver and coastal areas, with a strong working collaboration with Fraser Health. The Division has an important role in the UBC undergraduate medical curriculum, has a mature nephrology postgraduate training program, and participates actively in the Experimental Medicine and Clinical Investigator programs of the Department of Medicine. Research activities encompass both laboratory and clinical sciences, and combine genetic and molecular research, pharmacology and therapeutics, epidemiology and clinical trials, and population health and outcomes/economic investigations in renal disease and transplantation. Members of the Division assume leadership roles in the advancement of nephrology at provincial, national and international levels through their positions in the BC Provincial Renal Agency, BC Transplant Society, the VCH Regional Renal Program, the Kidney Foundation of Canada, the Canadian and International Societies of Nephrology, the Canadian Society of Transplantation, The Transplantation Society (international) and US National Kidney Foundation.

Teaching

The UBC Division of Nephrology is a key component of the tertiary education program for medicine and related health sciences for the University of British Columbia. Through its active undergraduate, graduate, post-graduate and continuing medical education programs the Division

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is responsible for the training of medical students, interns, residents, sub-specialty residents in nephrology, rotating trainees in general medicine, anaesthesia and other relevant disciplines, graduate and doctoral students, and clinical and research fellows. These programs attract trainees from across Canada, and from Australia, Europe, Asia and the Middle East. The primary sites for undergraduate and graduate training are at VGH, SPH/Providence Healthcare and the BC Children’s Hospital, with outreach to expansion school locations throughout British Columbia by way of videoconferencing. The Richmond General Hospital and Lion’s Gate Hospital will increasingly provide a platform for community nephrology training as the Division extends to these locations. Funding for the educational programs of the Division is provided by UBC, through the BCPRA, and from partnership contributions through the Division of Nephrology. Education in pharmacy and allied health disciplines occurs in the same sites under the auspices of UBC and related professional bodies. In 2007, Divisional program directors included Dr. Suneet Singh (Undergraduate Programs), Dr. John Duncan (Postgraduate Programs), Dr. Adeera Levin (Continuing Medical Education), and Dr. David Landsberg (Fellowship Programs).

Undergraduate education: The Division of Nephrology has contributed significantly to implementing the medical school’s expanded and distributed curriculum in 2007 and is actively involved in all areas of education throughout the undergraduate program. Dr. Suneet Singh is the Director of Undergraduate Education for the Division of Nephrology, supported by Drs. Copland, Neufeld, Levin, Chan-Yan, Jamal and other members of the Division. Nephrology subspecialty residents are actively involved in clinical case sessions. Dr. Singh and Dr. Levin coordinate medical student rotations through Nephrology at the VGH and SPH sites respectively, and Dr. Singh also works with Dr. Neufeld to organize the Renal 5 week block for the undergraduate program. Dr. Jamal and the administration staff at both sites serve as the student contact for electives and selectives. These rotations receive excellent evaluations and many students return as residents.

Postgraduate education: Dr. John Duncan is Director of the Postgraduate Education Program, which is widely recognized for the excellence of its clinical training. This highly-structured program encompasses the broad range of basic and clinical renal sciences with formal educational sessions and weekly resident and fellow’s rounds. The Program had 9 trainees enrolled in the first and second years of core nephrology training in 2007, and has an outstanding record of successful Royal College examination results. Elective opportunities are provided for subspecialty residents to pursue training in particular aspects of renal medicine, including histopathology, glomerular diseases, community nephrology, dialysis or transplantation, and other components according to their needs and interests. Residents and fellows are encouraged to be active in clinical research throughout their core years, with submissions to and presentations at meetings of the Canadian and American Societies of Nephrology, the American Society of Transplantation, the Canadian Transplant Society, and The Transplantation Society (international).

Graduate Education: The Division has an active fellowship education program under the direction of Dr. David Landsberg, which offers advanced and specialist training in clinical or laboratory sciences in many areas of renal medicine including chronic kidney disease, dialysis, transplantation, immunology and genetics/genomics. This training may be combined with formal graduate course work leading to Masters or Doctoral degrees in Experimental Medicine, Health Care and Epidemiology or related disciplines through the Faculty of Graduate Studies. In 2007,

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the Division hosted 1 postdoctoral research fellow and 2 clinical fellows from across Canada, as well as 8 international clinical fellows – 1 from each of Australia, Scotland, Ireland, Italy, Thailand and the Ukraine, and 2 from Great Britain. On January 1, 2008, we will welcome a 3rd clinical fellow from Montreal.

Continuing Medical Education: Members of the Division participate actively in Continuing Medical Education activities at the local, provincial, national and international levels, and in so doing bring an important measure of prestige to the Department and University. UBC Division of Nephrology rounds are held over 20 times per year, alternating between Vancouver General and St. Paul’s Hospital sites, with distinguished speakers invited from throughout North America and Europe. Distinguished Visiting Professors also visit the Division on a frequent basis to present individual seminars or conferences and interact with the members, trainees and staff during their visit. Drs. Levin, Keown, Shapiro and Gill maintained active speaking schedules in national and international meetings, presenting both reviews of key topics and original research in Nephrology and Transplantation, and other members of the Division are gradually acquiring national and international recognition in additional aspects of nephrology.

Research The Division has a strong and internationally-recognized translational research program in both renal disease and transplantation. Members of the Division currently held over $2 million in grant support in 2007, including grants from Genome Canada, the CIHR, the MSFHR and other peer- review agencies, and generated more than 20 scientific articles in 2007. The UBC Division of Nephrology research program is working to: (a) optimize the ongoing academic activities of current members by fostering effective collaboration, (b) ensure effective mentoring for new recruits to maximize their opportunities for academic success and (c) provide formal graduate and post-graduate scientific training for residents and fellows in Medicine, Nephrology and other disciplines, and for students from the Experimental Medicine and Clinical Investigator programs.

Our Divisional research unit at St. Paul’s Hospital site continued to benefit through 2007 from a well-staffed Research Unit, and strong funding from both industry and peer-reviewed agency support. The unit’s staff has significant presence in St. Paul’s Comox Building, and includes a Research Manager, Ms. Katy Vela, a number of highly-qualified Research Coordinators and Research Nurses, and a full-time Biostatistician, Ms. Caren Rose.

The Division continued development of a Nephrology Clinical Research Unit at the VGH site in 2007, to complement the strong research infrastructure already in place at St. Paul’s Hospital. In October 2007, this VGH unit acquired expansion space in the Gordon and Leslie Diamond Health Care Centre through research grant funding. The unit’s Senior Statistician, Dr. Robert Balshaw; Clinical Research Coordinator, Daniel Rogers; and Biostatistician, Dr. Guiyun Li; continued to offer support to a growing number of industry- and investigator-initiated studies. In late 2007, a contracted Medical Writer, Ms. Shawna Flynn, was added to the team, with a focus on the Biomarkers in Transplantation project

The Renal Sciences Program integrates members from the VGH and SPH / Providence Health sites to ensure full participation and collaboration, and to ensure appropriate academic space and resources for the proposed research at both principal hospital sites. The program is funded from

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multiple sources including peer review agencies, private research contributions, corporate partnerships and the creation of a strong industrial-academic interface. The principal components of the program are outlined below

Laboratory Sciences: Dr. Quamme’s research is focused on differential expression analyses that identify novel genes involved with magnesium transport and metabolism in human kidney. Using expression systems his group has experimentally characterized these transcripts offering novel clinical approaches to diagnoses of diseases. Dr. Quamme continues this line of investigation through identification of key molecular targets, regulation of gene expression, and cell signaling events. Dr. Wong’s research activity continues to explore the role of vasocative peptide in regulating the expression of vasopressin V2 receptor expression in the inner medullary collecting duct of the kidney, and of other vasoactive peptides including endothelin and AQP4 on the kidney, heart and brain. Dr. Keown's research has targeted the mechanisms, modulation and consequences of the immune response in organ transplantation and autoimmune disease, combining studies in molecular genetics, cell biology, pharmacokinetics and dynamics. Dr. Keown continues to co-leads a Genome Canada-funded ($9.1 million) search for predictive biomarkers of acute and chronic allograft rejection in heart, kidney and liver transplant recipients. This program is now being extended to explore biomarkers and disease mechanisms in glomerular injury and autoimmune diseases. Dr. Gill, a Michael Smith Scholar and Vice President of the Canadian Organ Replacement Register, has pioneered the investigation of alloimmunity following transplantation with the monitoring of anti-donor HLA antibodies using novel solid-phase fluorescent methods for antibody detection. Continuing research will build upon these above studies using newly established DNA/RNA banking facilities, signal analysis and high-throughput genomics and proteomic methods for molecular targeting, to investigate disease risk and therapeutic response genes, immuno pharmacodynamics /pharmacogenomics and measures of operational tolerance.

Clinical Sciences: Dr. Levin’s research encompasses the broad range of epidemiology, outcomes, and health policy in chronic kidney disease. Particular interests include the impact of anemia on renal co-morbidity, analysis of cardiovascular disease risk in patients with impaired renal function, strategies for and benefits of co-ordinated care for chronic kidney disease, the role of vitamin D in bone health and clinical outcome, measures of renal function, and societal measures of renal disease burden. Dr. Levin leads an active clinical training program for researchers in clinical epidemiology, translational physiology and health outcomes, which has 1 clinical scholar and 3 clinical research fellows participating. Of note, two of the research fellows have been referred here from international sources (UK and Italy). Dr. Levin holds a MSHRF planning award for additional research into complex disorders, currently supervises two international fellows (from Italy and the UK). Dr. Chiu is principal investigator on a number of proteinuria studies. Dr. Taylor is involved in national and international studies in peritoneal dialysis. Dr. Gill has established an important platform of clinical research in the epidemiology of renal transplantation which has examined the impact of increased donor age and recipient waiting times on outcomes of renal transplantation, the potential survival advantage of pre- emptive transplantation, the progression of kidney disease in native and grafted organs, and the incidence and consequences of cardiovascular disease during the waiting period. Dr. Gill is the recipient of a major CIHR award to further this research base. Dr. Keown’s research, supported by the CIHR, employs computer models to explore therapeutic interventions, health outcomes and service delivery in transplantation. Drs. Kiaii and Jastrzebski have focused on dialysis research

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related to vascular access and the clinical and economic impact of anemia management in dialysis recipients, while Dr. Duncan has examined gender relationships within the context of renal failure care, and the incidence, severity and functional impact of renal artery stenosis in patients with cardiovascular disease. Dr. Shapiro is engaged in outcomes related research in clinical transplantation, including studies of post-transplant diabetes, predictors and management of malignancy post-transplant, and pharmacokinetic, pharmacodynamic, and pharmacogenetic studies of immunosuppressive agents in transplant recipients. In collaboration with the Department of Neuropsychology at Simon Fraser University, she supervises two graduate students in research related to neurocognition in chronic renal failure and transplantation. The Division has a strong commitment to clinical and therapeutic trials, with many continuing single and multicentre Phase II - Phase IV studies. Further integration of the clinical research program will enable the introduction of advanced study methods and trial designs, and will permit all members of the division to become actively involved in the evaluation of new and innovative treatments.

Clinical Services

The renal services provided by the Division of Nephrology operate within a broad provincial context with established clinical guidelines, provincial contracts, information systems, central administration and co-ordination for education and other projects. This affords the Division an opportunity to be both a key contributor to and a beneficiary of provincial policies, projects and experience. British Columbia is widely recognized to be at the forefront of renal care delivery, with active programs for the early detection of renal disease in the population, multidisciplinary coordination of care, delivery of dialysis therapy in the community or at home, and novel approaches to renal transplant donation. The BC Provincial Renal Agency (BCPRA) coordinates the development and integration of renal services, funding, establishment of standards and guidelines, and works in collaboration with each of the health authorities to ensure equal access to care for all patients living with kidney disease. The BC Transplant Society coordinates the funding and oversight of renal and other solid organ transplant services and the retrieval of cadaveric organs and tissues.

Within this framework, renal care delivery is based on established principles of integrated chronic disease management through a combination of institutional, community and home-based programs. Three tertiary care teaching hospitals, the Vancouver General Hospital (VGH), St. Paul’s Hospital (SPH Providence Healthcare) and BC Children’s Hospital (BCCH), collaborate to provide ambulatory chronic renal disease care, in-patient management, plasma exchange (SPH), hospital dialysis and renal transplantation, and home hemo- and peritoneal dialysis for adult and pediatric patients with renal disease throughout the Vancouver Coastal Health and sections of the Fraser Valley region. The home hemodialysis program, headed by Dr. Michael Copland, is now one of the largest of its kind in North America. Dr. Singh is heavily involved in improving patient education about dialysis, and working with multidisciplinary teams to promote home dialysis in our region. With her assistance, the peritoneal dialysis (PD) program worked to establish the first long term care facility to do PD as a pilot project with measured outcomes. Community hemodialysis is conducted as an integrated program in six units, supported by three hospital-based units, and renal consultation is provided at Lion’s Gate Hospital and Richmond General Hospital. Almost 3,000 patients with chronic renal disease currently receive care within

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VCH, of whom over 1,000 have progressive CKD, almost 800 are on dialysis, and a further 800 have a functioning renal transplant. Recent figures estimate that many more subjects within this region may have chronic renal dysfunction without knowledge of the fact so that further innovation, coordination and integration of services will be essential to meet the impending challenge over the next decade and to improve maintain the standards of care already established by the Division.

In late 2007, the Division began recruitment plans for the addition of two further transplant nephrologists who will be added to the team at St. Paul’s Hospital and Vancouver General Hospital sites. In addition, our two newest members at the VGH site, Dr. Nadia Zalunardo and Dr. Peter Neufeld, complement the services in both university-affiliated hospitals and will expand the activities of the Division to the Richmond and North Shore regions.

Service to Community

Members of the Division of Nephrology play a key role in many University, academic community and volunteer organizations in Canada and around the world. Dr. Levin serves as Director of the BC Provincial Renal Agency, and Chair of the Curriculum Committee of the KRESCENT program, a collaboration between the Kidney Foundation, the Canadian Society of Nephrology and CIHR, established to enhance clinical research science training and career development. Dr. Gill is Vice-Chair of the American Society of Transplantation Guidelines Committee, Chair of the CST Communications Committee, and sits on the Steering Group for CCDT IM/IT Development and the Steering Committee for the CCDT Organ Allocation Forum. He is also involved in peer- review activities with the NIH, Kidney Foundation of Canada, Physician's Services Incorporated, and National Kidney Foundation. Dr. Keown is a member of Council of the Transplantation Society and Chair of the Organizing Committee for the XXIII International Congress to be held in Vancouver in August 2010. He is involved in numerous university, granting body and scientific journal committees. Dr. Copland brings significant contributions to the Kidney Foundation of Canada as: Immediate Past Chair of the National Medical Advisory Committee, and current Chair of the National Public Policy Council. He remains active as a member of the National Public Policy and National Patient Services Committees. Dr. Landsberg, Head of the Division of Nephrology for Providence Health Care/St. Paul’s Hospital, serves as Member of both the St. Paul’s Hospital Medical Advisory Committee and BC Transplant Society Medical Advisory Committee, while Dr. Shapiro is Medical Director of the Solid Organ Transplantation Program at Vancouver General Hospital and a member of the BC Transplant Society Medical Advisory Committee. Dr. Jastrzebski continues to serve as Member of the Canadian Society of Nephrology’sAd Hoc Committee for the Prevention of Infection in the Hemo-dialysis Unit. He also serves within the Vancouver Coastal Health region on the City-wide Hemodialysis Committee, the Vancouver Coastal Community Dialysis Committee, the Project Charter for Disaster Committee, the Pilot Project for TB Control (Provincial Guidelines for TB Control in the CKD Population), and as an ad hoc member of the Provincial Vascular Access Committee. Dr. Chan-Yan is Chair of the St. Paul's Hospital Department of Medicine Finance Committee, and sits on the University Clinical Faculty Appointment and Promotion Committee. Dr. Singh is a speaker at the BC Provincial Renal Agency’s Peritoneal Dialysis education day, and on the Organizing Committee for their annual B.C. Nephrology Days. She is also a reviewer for the journals Peritoneal Dialysis International (PDI) and Nephrology Dialysis Transplantation (NDT).

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Administration

In late 2007, the Vancouver General Hospital site expanded their previous 4,000 ft2 space in the new, state-of-the-art Gordon and Leslie Diamond Health Care Centre by an additional 1,800 ft2 to meet the needs of its expanding Clinical Research Unit, complementing the research space allocated at the St. Paul’s Hospital site to provide further opportunities for renal research. Dr. Paul Keown, Professor of Medicine, continued in 2007 as Head of the Division of Nephrology and Director of the VCH Regional Renal Program. The Division has continued to build an effective administrative and financial infrastructure to support growth and development, with Mr. Shawn Jorgensen continuing to serve through 2007 as Executive Administrator.

All aspects of our Divisional education programs, including undergraduate, postgraduate and fellowship activities, continued to have strong support in 2007 from Ms. Pam Sewell at the St. Paul’s Hospital site. In October 2007, Ms. Heather Chitty, who had provided tremendous support and development for our Education program at VGH for several years, relocated back to her Ontario hometown. Mrs. Tammie Davis, previously part of the Nephrology clinical administrative team at the VGH site, officially became part of the Divisional staff on November 1, 2007 as our Education Program Coordinator. She will continue to build on the excellent foundation Ms. Chitty left behind, with an expanded role in financial administration and patient relations.

Plans are already underway for 2008 to add administrative and research personnel to fulfill the clinical service, teaching and research goals and objectives of our growing Division.

Future Directions

The Division will continue to build on its strengths to ensure the highest quality of academic and clinical activity for the University, the health system, and the community. The Division will work to develop a Centre for Innovation in Renal Sciences, with the support of both the VGH & UBC Hospital Foundation and St. Paul’s Hospital Foundation, which will integrate existing activities in the fields of laboratory and clinical sciences and expand into novel areas of cutting-edge research. The Division also gave impetus in late 2007, in concert with the Dean of Medicine’s office, the Heads of the UBC Departments of Medicine, Medical Genetics, Pathology, Surgery and Urologic Sciences, and the VCH Research Institute, to the creation of an institute focusing on translational and regenerative medicine and bringing together several Centres and programs to create synchronicities and economies of scale and foster the development of research activities. Plans are being developed for an early-2008 developmental meeting on that front.

The Division will continue to take a major role in the teaching of Renal Sciences within the University, continue its leadership position in nephrology postgraduate education, and introduce innovative initiatives in the delivery of integrated regional care for patients with renal disease.

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NEUROLOGY

Dr. Howard Feldman Professor & Head

Faculty Members

Professor & Head Feldman, Dr. Howard VA Professor Barton, Dr. Jason VA Professor Cashman, Dr. Neil VA Professor Doudet, Dr. Doris VA Professor Illes, Dr. Judy UBCH Professor Oger, Dr. Joel VA Professor Pelech, Dr. Steven VA Professor Rieckmann, Dr. Peter VA Professor Stoessl, Dr. Jon VA Professor Tsui, Dr. Joseph VA Professor Wang, Dr. Yu Tian VA Associate Professor Curt, Dr. Armin VA Associate Professor Kastrukoff, Dr. Lorne VA Associate Professor McKeown, Dr. Martin VA Associate Professor Jacova, Dr. Claudia UBCH Assistant Professor Hsiung, Dr. Ging-Yuek Robin SPH Assistant Professor Traboulsee, Dr. Anthony VA Assistant Professor Tremlett, Dr. Helen VA Clinical Associate Professor Beckman, Dr. Jeff VA Clinical Associate Professor Hooge, Dr. John SPH Clinical Associate Professor Javidan, Dr. Manouchehr VA Clinical Associate Professor Jones, Dr. Michael VA Clinical Associate Professor Keyes, Dr. Robert SPH Clinical Associate Professor Krieger, Dr. Charles VA Clinical Associate Professor Robinson, Dr. Gordon VA Clinical Associate Professor Teal, Dr. Philip VA Clinical Assistant Professor Briemberg, Dr. Hannah VA Clinical Assistant Professor Clarke, Dr. Stephen SPH Clinical Assistant Professor Costantino, Dr. Anthony Abbotsford Clinical Assistant Professor Devonshire, Dr. Virginia VA Clinical Assistant Professor Foti, Dr. Dean VA

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Clinical Assistant Professor Gibson, Dr. Gillian VA Clinical Assistant Professor Johnston, Dr. Dean SPH Clinical Assistant Professor Katz, Dr. David VA Clinical Assistant Professor Martzke, Dr. Jeffrey VA Clinical Assistant Professor Mezei, Dr. Michelle VA Clinical Assistant Professor Murphy, Dr. Colleen VA Clinical Assistant Professor Prout, Dr. Alister SPH Clinical Assistant Professor Spacey, Dr. Sian VA Clinical Assistant Professor Thiessen, Dr. Brian VA Clinical Assistant Professor Woolfenden, Dr. Andrew VA Clinical Instructor Bozek, Dr. Christopher Burnaby Clinical Instructor Chapman, Dr. Kristine SPH Clinical Instructor Hallam, Dr. Bradley VA Clinical Instructor Smyth, Dr. Penelope VA Clinical Instructor Tai, Dr. Charles SPH Clinical Instructor Tessler, Dr. Barry RCH Clinical Instructor Townsend, Dr. Tiffany VA Clinical Instructor Varelas, Dr. Michael VA Associate Member Anderson, Dr. Duncan VA Associate Member Forwell, Dr. Susan VA Associate Member Graeb, Dr. Douglas VA Associate Member Hurwitz, Dr. Trevor VA Associate Member Leavitt, Dr. Blair VA Associate Member Li, Dr. David VA Associate Member Moore, Dr. Wayne VA Associate Member Raymond, Dr. Lynn VA Associate Member Sadovnick, Dr. Adele VA Associate Member Stowe, Dr. Robert VA Associate Member Wilkinson, Dr. Rosemary VA Adjunct Professor Bub, Dr. Daniel U Victoria Adjunct Professor Ruth, Dr. Thomas VA Professor (Emeritus) Calne, Dr. Donald VA Professor (Emeritus) Eisen, Andrew VA Professor (Emeritus) Kim, Dr. Seung VA Professor (Emeritus) Pate, Dr. Brian VA Professor (Emeritus) Sweeney, Dr. Vincent VA Clinical Professor (Emeritus) Anzarut, Dr. Andre SPH Clinical Professor (Emeritus) Bratty, Dr. Paul VA Clinical Professor (Emeritus) Hashimoto, Dr. Stanley VA Clinical Associate Professor (Emeritus) Wong, Dr. Milton SPH

Divisional Overview

The Division of Neurology is the largest division within the Department of Medicine. It has its major teaching, research and clinical activities at Vancouver General Hospital, UBC Hospital, and St. Paul’s Hospital. There are 49 Neurology faculty members whose primary appointment is in the Division, with another 11 appointed as associate members, 2 as adjunct professors and 9 as UBC Department of Medicine Page 116 Annual Report 2007

emeritae. The Division also has been expanding its breadth of membership to include a broader range of neuroscience disciplines. There is a strong emerging core of basic bench neuroscientists, clinical neuropsychologists and cognitive neuroscientists.

The Division is nationally and internationally recognized for its clinical and research programs in Parkinson’s disease, the dementias, multiple sclerosis and stroke. It has been consistently extremely successful in obtaining peer reviewed grant funding from agencies in Canada and internationally. Divisional members make important contributions to both basic neuroscience and clinical neurological literature. This past year divisional members published more than 137 papers in peer-reviewed journals. Clinically, the Division provides province-wide tertiary and quaternary care for a variety of neurological disorders. The division has clinical outreach to many communities around the province. Faculty are actively involved in teaching and supervising all levels of students and trainees from undergraduate to post doctoral fellows.

Among the highlights for the Division in the past year has been the successful recruitment of several key faculty to leadership positions. Dr. Peter Rieckmann from the University of Wurzburg has taken up a position as the new Endowed Multiple Sclerosis Society of Canada Research Chair and Dr. Judy Illes has been appointed as a Tier 1 Canada Research Chair in Neuroethics with a mandate from CIHR to develop a new National Core for Neuroethics that will be headquartered at UBC. Dr. Howard Feldman was recognized for his accomplishments in dementia research as the first recipient of the Ralph Fisher and Alzheimer Society of British Columbia Endowed Professorship in Alzheimer’s disease research.

The Division had major programmatic launches in 2007 with the Pacific Parkinson’s Research Center lead by Dr. Jon Stoessl, initiating their CIHR and Michael Smith Foundation for Health Research team grant and research unit awards. Additionally a large Center grant was awarded to Dr. Stoessl as PI by the Pacific Alzheimer’s Research Foundation (PARF) to lead an investigation of overlap syndromes in neurodegenerative diseases between Mayo Clinic Jacksonville investigators and investigators at UBC.

In 2007, there was continued momentum towards the vision of a Center for Brain Health at the UBC campus. This is a partnership program being developed between the Brain Research Center, the Department of Psychiatry, the Faculty of Medicine, VCHRI and the Division. It is directed at reaching a funding goal of $ 100 million to create a new translational research facility at the UBC campus. This facility would provide a state of the art clinical research environment for the study of neurological and psychiatric illnesses and their interrelationships and would further foster the close working relationship of bench neuroscientists and clinical researchers. A number of members of the Division have spearheaded the applications that have included a successful CFI application in the late fall of 2006, a federal government award of $17 million for a Center of Excellence for Commercialization and Research and a further application to CFI in the fall of 2007 through the Research Hospital Fund (result pending).

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Teaching Programs

Undergraduate: Division members are involved as PBL facilitators, lecturers and clinical skills tutors in the Brain and Behaviour block during 2nd year. The clinical skills sessions have been augmented by the recruitment of volunteer patients from neurology ambulatory care clinics. These patients were recruited from outpatient clinics by Division members.

The Neurosciences clinical skills sessions are supported by extensive video learning materials demonstrating the normal neurological examination including mental status testing as well as a wide array of neurological abnormalities. Each second year medical student is provided with a DVD to be used in conjunction with the tutorials that are given by neurosurgeons and neurologists from VGH, UBCH and SPH. The material has been developed and is continually updated by Dr. Gordon Robinson (program coordinator undergraduate education) who has considerable experience in using video for teaching. The Division recognizes the able assistance of Mr. Gordon Gill who has generously donated his time and expertise in television production to assist in developing these teaching materials.

Third year medical students receive a two-hour seminar and a bedside teaching session during their internal medicine CTU rotation. The Neurology CTU has become a regular rotation at VGH beginning in early 2007. This has been enthusiastically accepted by the Division as a way of increasing exposure to neurology as a discipline.

In addition a 4 week elective/selective clerkship is offered based on an inpatient and outpatient experience that allows students to take advantage of all of the resources within the Division. As well as UBC students the clerkship attracts students from other medical schools in Canada and other countries. Students who have participated in this rotation uniformly report that Division members are committed and enthusiastic teachers. They also comment on the valuable contribution made by the residents in neurology.

Other division members led by Dr. Tony Traboulsee are an integral part of Phase VI, providing curricula designed to encourage critical evidence-based management of clinical problems.

Postgraduate: The Post Graduate Residency Training in Neurology is fully accredited with the Royal College of Physicians and Surgeons. It currently has 21 residents at various levels of training from PGY1 to PGY5. There are 5 CaRMS positions for academic year 2007. A Divisional web site (www.ubcneurology.com) has been developed with a postgraduate component including schedules, scientific papers and future projects. The web site was developed by Dr. Naveen Deshpande (R3) with input from our divisional staff.

In the first two years of the program, the residents rotate through various subspecialties in Internal Medicine, ICU, Emergency, as well as doing their first Neurology rotations. The PGY3-5 years are core Neurology training years. Residents do their inpatient training at Vancouver General Hospital and St. Paul's Hospital. Many outpatient subspecialty clinics are done at UBC Hospital. During their training the residents in Neurology are actively involved in various research projects.

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In 2007 there were 3 resident poster presentations at various international meetings and 2 peer- reviewed publications. Dr. Raed Al Roughani, the chief resident in Neurology was awarded a Resident Scholarship Award for the American Academy of Neurology Annual Meeting in 2007. Graduate, Doctoral, Postdoctoral Students and Fellows: The Division has an active program supporting students at all levels of neuroscience and neurology training. In 2007 there were 20 trainees mentored by Divisional faculty: Alzheimer’s Disease and Related Disorders: Fellows: Dr. Najeeb Qadi (Saudi Arabia), Dr Naga Kandiah (Singapore), Dr Ummamon Puanthong, (Thailand) Parkinson’s Disease and Movement Disorders (Pacific Parkinson’s Research Center): Clinical fellows: Dr. Nandhagopal Ramachandiran (India), Dr. Sujith O.K (India), Dr. Sulaiman Al Khashan (Quwait)

Multiple Sclerosis and MRI: Post-doctoral fellow: Dr. Elaine Kingwell, Graduated (PhD) from Health Care and Epidemiology, UBC (2007); Neurology resident: Ana-Luiza Sayao, MD. Supervised her research electives: Nov/2007.

Neuro-ophthalmology: Clinical fellows: Dr. Martin Sutton Brown (Calgary) Dr Amadeo Rodriguez, Pedro Lagleyze (Argentina) Post-doctoral research fellows: Dr. Ann Marie Grbavec, (computational modeling SFU), Dr Giuseppe Iaria, (neuropsychology, Rome, Italy), Dr. Linda Lanyon, computational neuroscience, (University of Plymouth, UK), Dr. Simon McCrea, (neuropsychology, University of Pennsylvania, PA),Dr. Ipek Oruc, (neuropsychology, New York University, NY), Dr. Wieske van Zoest, (cognitive psychology, Vrije Universiteit Amsterdam, Netherlands); Graduate students: Kirsten Dalrymple, MSc program psychology, UBC. Chris Fox, PhD program neuroscience, UBC.

Neuroethics: Post-doctoral fellows: Robin Pierce, J.D., Ph.D., Senior Research Fellow, Emily Murphy, Ph.D., Postdoctoral Fellow Affiliate, Stanford University.

Epilepsy: Clinical fellow: Dr. Iftetah Alhomoud (Saudi Arabia)

Vancouver General Hospital Neurology Service (Clinical Teaching Unit)

The in-patient service at VGH consists of a 14 beds unit located on T5-B of the Pattison Pavilion. This unit is the only dedicated hospital neurology clinical teaching unit (CTU) in the province and has within its mandate the provision of tertiary care for complex neurological disorders. The inpatient program features a specialized epilepsy monitoring unit (2 beds) and Acute Stroke Unit (2 beds). Life, Limb and Threatened Organ policies approved by the Vancouver Acute Medical Advisory Committee are in place for accepting acute stroke patients, as well as neuromuscular disorders requiring plasmapheresis.

A large percentage of all stroke patients presenting to the emergency room or referred to VGH are now admitted to the Neurology service for acute management during the first 5-7 days of their post stroke care. From there the stroke pathway includes transfer to the UBCH Subacute Stroke Unit or other appropriate rehabilitation facilities or home. This has resulted in an increase in the number of stroke patients cared for on neurology with the elimination in patients requiring a

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prolonged stay on the unit. During 2007 there was an increased volume of stroke referrals in the emergency department and an increased number of stroke inpatient admissions.

The VGH and UBCH neurologists provide important consultation services within Vancouver Acute. Neurological diagnostic services at VGH include electroencephalography (EEG), intraooperative monitoring (IOM) and electromyography (EMG) are based at VGH.

Ambulatory services provided include subspecialty clinics for movement disorders, multiple sclerosis, headache, ALS, Alzheimer’s disease and other dementias, stroke, neuromuscular disease, and neuro-oncology. At the Diamond Ambulatory Care Centre there are clinics for headache, stroke and epilepsy.

These clinics integrate with a strong research environment for each of these programs, which in turn form the core of the academic mission of the Division. The clinics also provide important post-graduate educational activities for trainees within the Division.

St. Paul's Hospital Division of Neurology

The St. Paul’s Hospital Division of Neurology is an important part of the clinical and teaching program of the UBC Division of Neurology. Dr. Robert Keyes is the division head of SPH. This division provides tertiary referral care for the Providence Health Care network as well as to the province more widely. The SPH division participates in an important and extensive outreach program to communities in northern BC and the Yukon territory. It is additionally involved in providing inpatient consultation services to the Mount St. Joseph’s Hospital site and Women’s Hospital. The division has opened an outpatient neurology clinic at the Mount St. Joseph’s Hospital Site to meet the needs of the patient population it serves. At SPH there is a Rapid Access Neurology Clinic where patients requiring urgent but not emergent care are seen and provide clinical service especially to the patient population arising from the downtown core.

The members of the Division of Neurology at SPH includes a wide cross section of subspecialty interests including clinical neurophysiology, neuromuscular disease, multiple sclerosis, neurological diseases in pregnancy, cerebrovascular disease and neurological diseases in HIV and AIDS. A close link between the Division of Neurology at SPH and the Department of Pediatrics and the Department of Obstetrics continues by virtue of the subspecialty interests of Dr. Keyes.

Specialty Programs in the Division of Neurology

Alzheimer’s Disease and Related Disorders Program Faculty: The Clinic for Alzheimer’s Disease and Related Disorders recruited Dr. Claudia Jacova (Cognitive Psychologist) as a PhD research scientist and also had Dr. Robin Hsiung relocate to the UBCH to further support his research and clinical activities in dementia and geriatric cognitive disorders. Dr. Howard Feldman (Clinic Director) was honoured as the inaugural recipient of the Fisher Family and Alzheimer Society of BC Endowed Professorship in Alzheimer Research. This professorship will be used to foster junior faculty in the early years of their careers and forms an important base of long term secure resourcing.

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Clinical Activities: The Clinic for Alzheimer Disease and Related Disorders is the main tertiary care referral center in B.C. for dementia assessment and management. New referrals can include a range of multidisciplinary assessments including Genetic Counselling, Social Work, Neuropsychology, Geriatrics, Geriatric Psychiatry and Neurology each of which make seminal contributions to the multifaceted clinical care needed for dementia patients and their families. It is also recognized as one of the most accomplished specialty clinics and clinical dementia research centers in Canada. In 2007 the Clinic undertook evaluations of more than 1200 patients with a range of neurodegenerative and other geriatric cognitive disorders. Its referred population has included an ever increasing younger cohort of subjects under age 55 in addition to an expanding over age 80 group. A large data base supports the administrative and research core activities of the Clinic and includes almost 3 decades worth of data.

Research Activities: The Clinic’s research focus is broad with faculty interests linked to basic discovery neuroscience research, neuroimaging (PET, MRI), cognitive neuroscience, epidemiology and clinical trials. There are key collaborations with Dr. Ian Mackenzie in support of neuropathological clinical correlative and basic science discovery research as well as with Steven Pelech in trying to determining the potential of a unique proteomic footprint for Alzheimer’s disease. Research projects include UBC’s participation in the NIH sponsored Alzheimer’s Disease Neuroimaging Initiative (ADNI) as well as supporting large scale Canadian programmatic grants such as the RAPID.

Frontotemporal degenerations continue to be a key area of research progress within the unit. In the past year discoveries have been made around TDP 43 in FTD, and ALS and their relationships. The availability of well characterized families with autosomal dominant pattern of inheritance has supported key genetic discovery research with current focus on elucidating the gene on chromosome 9p for FTLD-U ALS. In clinical trials the Clinic has achieved a leadership role with Principal Investigator status in a number of large scale RCTs including the LEADe and InDDEx studies.

In 2007, the research activities of the Clinic included a mix of peer reviewed funded research projects from the Canadian Institutes of Health Research (CIHR), the National Institutes of Health (NIH), and clinical trials both investigator initiated as well as industry sponsored. Ongoing research areas include the development of volumetric analytic techniques for MRI in mild cognitive impairment, and the long-term characterization of clinical outcomes in the observational ACCORD cohort study.

The development of a data management core for investigators at the Brain Research Center has been an important major initiative that has continued to broaden its scope in 2007 with numerous new data sets received for secondary innovative analyses. The data management group has been coordinating the data management and studies across a range of neurologic and psychiatric illnesses including manic depressive illness, multiple sclerosis as well as dementia. The research unit had 4 international fellows in 2007. New initiatives included a successful large peer reviewed grant on overlap neurodegenerativev diseases in collaboration with Mayo Clinic Jacksonville headed by Dr. Jon Stoessl (PI) with FTD clinical core Dr Howard Feldman (PI) and Neuropath core Dr Ian Mackenzie (PI). A renewal application for FTLD-U funding was submitted to CIHR.

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Teaching Activities: The Clinic has been very active in providing teaching to trainees of multiple disciplines at the student, graduate student, resident and fellow levels. A formal one-day preceptorship training program for family physicians and specialists is in place and there have been several international colloquia that the Clinic has sponsored through the Brain Research Center where groups of neurologists and neuroscientists participate in a several day program. In 2007, a group of Thai neurologists attended this program with planning for a Canadian Dutch Colloquium in 2008. Clinic members participated extensively in CME activities, and on expert national international working groups and advisory committees. The Clinic is very active in public education and its clinicians have also been called on to have a high profile in national and international public policy in dementia care. The Clinic has been working closely with the Alzheimer Society of British Columbia with a number of successful projects reaching their conclusion in 2007. In partnership with the Knowledge Network an important documentary “Beyond Memory” was completed and released. An interactive website was completed in partnership with VCH and early support groups initiated.

Stroke and Cerebrovascular Program Faculty: The Vancouver Hospital Stroke Program is actively recruiting two additional stroke neurologists at both the academic and clinical level. In order to maintain the current level of clinical service, improve the management of hospitalized stroke patients and to further academic and research missions it is necessary to develop a different medical model that will permit the retention and recruitment of qualified stroke neurologists. It is hoped that this change will be accomplished within the next year.

Clinical Activities: The VGH serves as the tertiary referral centre for stroke and cerebrovascular diseases in B.C. To support this clinical role the VGH Stroke Program maintains a dedicated on- call system with the commitment of five neurologists. A “Stroke Hot Line” pager system is available 24/7 to triage patients from around the lower mainland and southern British Columbia. The VGH Stroke Team consists of stroke neurologists, diagnostic and interventional neuroradiologists, neurointerventional/neurovascular neurosurgeons, and vascular surgeons. The program provides state-of-the-art care to cerebrovascular patients. Neuroradiology provides superb diagnostic and interventional services. In cooperation with the BC Bedline the program has successfully developed an acute stroke referral system for the provision of thrombolytic and interventional stroke care.

Over the past year consider effort has been made to develop a British Columbia Stroke Strategy in collaboration with the Heart and Stroke Foundation, and the Canadian Stroke Strategy. Additionally, there are several planning committees developing a regional stroke plan to serve the Vancouver Coastal Health Care Region. An organized plan for regional stroke care will ensure that patients will receive optimal stroke care and that resources will be efficiently utilized.

The VGH Stroke Prevention Clinic continues to provide urgent clinical and diagnostic services to patients. The Stroke Clinic currently sees over 3,000 new TIA and Stroke patients annually. Most key diagnostic tests are performed the day of the clinic visit and definitive to meet increased demands the clinic is now operating three days a week and will need to further expand its services. These clinics provide a critical service for patients at risk of stroke and provide a sub

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specialized resource to emergency departments and physicians. Prompt and expert care reduces the need for hospitalization through the rapid evaluation of patients.

Teaching Activities: The VGH Stroke Program undertook its well subscribed Annual Western Canada Stroke Conference again. This program has been highly successful in its mission to provide stroke education to neurologists from B.C. and western Canada. Weekly stroke rounds are held to provide education to residents and medical students. Residents and students spend time in the Stroke Prevention Clinic evaluating and making decisions on urgent cases. The Stroke neurologists continue to give Grand Rounds, medical rounds and talks at CME events to educate physicians around the province. Public forums have been held by the Heart and Stroke Foundation with the participation of stroke neurologists and others. On an international level, members of the Stroke Program delivered posters and platform presentations at the International Stroke Conference, the Canadian Congress of Neurological Sciences, and the European Stroke Conference. Numerous CME events have been conducted locally and provincially.

Multiple Sclerosis Program Faculty: The clinic has 8 neurologists (Drs. V. Devonshire, S. Hashimoto, J. Hooge, L. Kastrukoff, J. Oger, P. Rieckmann, P. Smyth and A. Traboulsee) and 3 neuro-ophthalmologists (Drs D. Anderson, J. Lindley and K. Wade). Dr. Rieckmann will provide overall leadership to the MS program with Dr V. Devonshire as the clinical Director of the M S Clinic, Dr A. Traboulsee as the head of Clinical Trials along with Drs. L. Kastrukoff, V Devonshire and Dr. P. Rieckmann as co-directors. Dr. Devonshire, along with Dr. Paul O’Connor from the University of Toronto, has developed revised national guidelines for the treatment of MS with currently available therapies. This is an important initiative that is supported by the Canadian Network of MS Clinics. Dr. Rieckmann has recently been elected as director for the western pacific region for the endMS initiative of the Canadian Multiple Sclerosis Society.

Clinical Activities: The MS Clinic had 3698 patient visits and 635 new patients in 2007. The clinic continues to have an active international profile and is used as a resource for research, training, and education.

The Clinic maintains important interdepartmental collaborations to optimize care to affected patients and their family members as appropriate. In particular the close collaborations include Dr. A. D. Sadovnick and her team (genetic & reproductive counseling,), Dr. A. Jiwa/ J. Tham (psychiatric care), Dr. S. Elliot (sexual medicine care) and Dr. Fenster (neuro-urology). The clinic coordinates new escalating therapy options for aggressive MS. The clinic also provides specialized care for neuromyelitis optica (NMO), an aggressive form of optic nerve and spinal cord demyelination with special focus on the evolution of new phenotypes in the asian immigrant population. The MS clinic also has important collaborations with the Cell Separator Unit at VGH site with Dr. Traboulsee and Dr. Oger serving on the Neuroplex Committee.

The clinic provides outreach to 3 satellite clinics in Victoria (1000 patients registered), Kelowna (700 patients), and Prince George (300 patients), as well as providing outreach care directly to patients in Comox. A new clinic collaboration will soon be set up in Kamloops.

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In collaboration with Pharmacare and with educational funding from the pharmaceutical industry, it has been possible to continue the valuable “MS Special Therapy” program to help educate patients in their choice for Disease Modifying Therapies (DMT) and management of their potential side effects. There are over 2000 treated patients in this program.

Research Activities: Drs H. Tremlett and V. Devonshire have published on new important aspects on the natural history of Multiple Sclerosis with particular emphasis on the different phenotypes based on the unique UBC Costar database. Their research has shown that the long term prognosis in MS is more favorable than previously described but that there are no early clinical prognostic indicators. Dr. Oger along with M. E Gibbs, R. Lam and T. Aziz have optimized the interferon antibody assays. They are now running nationwide antibody testing utilizing the Luciferase assay and comparing their results to that of the other assays. The UBC lab is now part of the NABIMS European Group (Neutralizing Antibodies in MS) to globally evaluate the best assay for monitoring patients under beta-interferon treatment. Dr. L Kastrukoff has been working on animal modeling of Herpes simplex virus type1 (HSV 1) induced central nervous system demyelination with focus on how resistant strains are able to prevent viral access to the brain during the acute stage of infection and thus eliminating the risk of developing demyelination at a later stage of their lives. Dr. Sadovnick is a Michael Smith Distinguished Scholar and recipient of the MS Society of Canada National Award of Merit. She has received over 4 million dollars from the MS Society of Canada Scientific Research Foundation to continue the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS) into Phase 5. She is also a co-investigator on a grant to study the conversion from CIS to pediatric MS. She has initiated a Multiple Sclerosis North American Pregnancy Program (MS-NAPP) in collaboration with the MS Society of Canada, National (US) MS Society and the Consortium of MS Clinics. In April 2007, Alex Rauscher, a leading expert in the Susceptibility Weighted Imaging (SWI) technique, joined the MR group. He brings new expertise in studying the problem of venous lesions as they relate to demyelinative pathology. The MRI group continued to develop and optimize techniques for measuring MS pathology, notably accurate water content and myelin water content measurement.

The MS clinical trials group had 15 ongoing trials in 2007 with over 700 subject visits. Therapeutic trials in MS have encompassed both disease modifying and symptomatic therapies. All stages and types of MS have been represented. The largest trial is aimed at secondary progressive MS (BioMS) with an innovative treatment approach. The group continues to have a strong profile in clinical trial development, safety monitoring and MRI/immunology sub-studies:

The MS/MRI Research Group has provided central analysis for numerous international multicenter randomized clinical trials and are recognized internationally for their work in this area. Dr. Oger has performed add on studies for Aventis Phase II and BioMS studies. His laboratory is also providing nationwide service for the neutralizing antibody testing in patients under treatment with one of the approved beta-interferon treatments.

Teaching Activities: Members of the MS Program actively recruit students for the neuroscience and experimental medicine graduate programs. They have lectured locally, in the region, nationally and on different international conferences on important aspect of optimized MS treatment and care. The MS Program offers research-training opportunities for students and

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residents, which has resulted in highly recognized publication (e.g. A.L. Sayao’s manuscripts on benign MS in Neurology). The UBC MS program offers clinical and research fellowships for neurologists who are interested in building a career as clinician scientists and acts as a regional center for the end MS training and research network of the Canadian MS society.

Neuroethics Program With the remarkable pace of advances in the neurological sciences, ethical, legal, policy, and social issues have garnered significant attention in both the academic and clinical communities, and in the eyes of the general public. Historically, consideration of the ethical implications of frontier technology has lagged the development of the technology itself. This challenge has enabled the division to conceptualize and develop a program in Neuroethics. The recruitment of Dr. Judy Illes as a tier I Canada Research Chair with funding from CIHR for a 5 year program award has facilitated the development of a new National Core for Neuroethics in the Division of Neurology, opened in August 2007 at UBC. Its mandate is to tackle these challenges head-on, working hand-in-hand with practicing clinicians and neuroscientists to ensure the close alignment of innovation with societal and individual human values.

Faculty: The Core is led by Judy Illes, Ph.D., Canada Research Chair in Neuroethics and Professor of Neurology. Senior faculty is Peter Reiner, Ph.D., Professor of Psychiatry, UBC. The Core is staffed by Robin Pierce, J.D., Ph.D., Senior Research Fellow, Sofia Lombera, B.SC., Manager for Research and Global Partnerships, Patricia Lau, B.Sc., Clinical Neuroethics Coordinator, and Emily Murphy, Ph.D., Postdoctoral Fellow Affiliate, Stanford University. It is funded by CIHR, CFI, BCKDF, the Greenwall Foundation, and the

Dana Foundation. An RO1 grant from NIH/NIMH “Advanced Neuroimaging: Ethical, Legal and Social Issues” will begin in April 2008, enabling the Core to double in size. The website http:// www.neuroethics.ubc.ca for more information.

Research Activities: Research in the Core is focused on high impact, high visibility areas in the neurological sciences, including basic and translational neuroimaging, commercialization of neurotechnology, clinical findings detected incidentally in research, healthy aging and regenerative medicine, and patient and physician engagement on an international scale.

Neurogenetics Program Faculty: The initiatives in Neurogenetics have brought together a group of researchers including Dr. Sian Spacey, Dr. Michelle Mezei, Dr. Blair Leavitt, Dr. Robin Hsiung, Dr. Dessa Sadovnick, Dr. Lynn Raymond and a group of genetic counsellors. The Neurogenetics Clinic at UBC Hospital is a tertiary referral center for all British Columbia providing over 400 outpatient visits in 2007. The patients seen have a wide range of inherited peripheral and central CNS disorders the most common include the spinocerebellar ataxias, Friedrich’s ataxia, dystonias, channelopathies, hereditary spastic paraparesis, the phakomatoses, myotonic dystrophy, CMT, ALS, and mitochondrial disease. Many of these patients are participants in genetic research run through the UBC Neurogenetics Unit, and have donated DNA to the clinic DNA bank. As well, there are neurogenetics arms of the Alzheimer and MS Clinics which provide genetic counselling to patients and families with these disorders.

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Clinical Activities: The Huntington Clinic at UBC was established in 1996. It serves as a tertiary referral centre for the province and also evaluates patients from other provinces across Canada when necessary. Patients and their families receive comprehensive care from a multidisciplinary team including two neurologists (Drs. Blair Leavitt and Lynn Raymond), a psychiatrist (Dr. A.D. Goumeniouk), a genetic counsellor, and a social worker. A DNA bank and brain bank established by Drs. Michael Hayden and Blair Leavitt facilitate research to investigate genotype-phenotype correlations.

Research Activities: The UBC HD Clinic is one of the most active centres in the Huntington Study Group (HSG), an organization that unifies the HD clinical research efforts of more than 60 centres across North America, Europe and Australia. The UBC site has participated in eight nine multi-centre research studies coordinated by the HSG; five of these are ongoing. Drs. Leavitt and Hayden have served as co-PIs for two of these studies. In addition to the HSG sponsored multicentre studies, Dr. Blair Leavitt has been a co-PI and/or site PI of three additional multi-centre research studies; one of these, TRACK-HD, was initiated in 2007 and brings in more than $2 million in funding for the UBC site.

Neuromuscular Diseases Program Clinical Activities: The Neuromuscular Disease Unit has its clinics on the 8th Floor of the Gordon & Leslie Diamond Health Care Centre. Its organization includes clinics in Myasthenia Gravis, mitochondrial myopathy, peripheral neuropathy and these are the largest of their kind in BC. Research Activities: The Myasthenia Gravis clinic is participating as a centre for the NIH/NINDS multinational Thymectomy trial in Myasthenia Gravis. Dr. Mezei completed a study of thymic pathology in Musk positive patients with seronegative myasthenia gravis and a case review of 40 patients with Chronic Progressive External Ophthalmoplegia. Drs Gibson and Chapman have ongoing diabetic neuropathy clinical trials, with an upcoming trial for neuropathic pain in diabetic neuropathy.

Dr. Chapman completed a study of radiation induced brachial plexus injury and is a neurophysiology examiner for the CSCN examinations.

Teaching Activities: The NMDU is active in resident teaching from multiple disciplines including neurology, rehab medicine. As well it is developing fellowship training.

Amyotrophic Lateral Sclerosis Program Clinical Activities: The ALS Centre at GF Strong is a trans-disciplinary entity providing care, teaching and basic research in the Vancouver area. Its clinic at GF Strong Hospital is staffed by three neurologist physician-scientists (Drs. Briemberg, Cashman and Krieger), one physiatrist (Dr. Travlos), and a specialized nurse coordinator (Marife Fabros). The physicians synergize with the ALS Team at GF Strong to provide clinical services to affected patients and their families. The ALS Society of BC (ALSBC) and the ALS Centre have recently formed an innovative partnership to provide a successful outreach clinic program for remote areas of the province.

Research Activities: Three major scientific programs are being conducted at the ALS Centre. Dr. Briemberg leads clinical trials for the ALS Centre, in collaboration with other team members and with the encouragement and financial assistance of ALSBC. Two clinical treatment trials are

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underway, and an additional trial is being considered through the newly founded Canadian ALS Clinical Trials and Research Network (CALS). In future it is possible that the scope of clinical trials may expand with assistance from ALSBC to include new medical devices and technologies for improving the quality of life with ALS. Dr. Krieger’s CIHR-supported basic scientific program at Simon Frasier University is focused on the engraftment of stem cells in the affected CNS of mouse models of ALS, with collaborative interaction Fabio Rossi at the UBC Biomedical Research Centre. Drs. Cashman, Krieger and Andrew Eisen, Professor Emeritus and past ALS Clinic Director are publishing in Muscle and Nerve a study on G-CSF, a stem cell mobilizing factor, in the treatment of ALS. Dr. Cashman is a Canada Research Chair in Neurodegeneration and Protein Misfolding Diseases at the UBC Brain Research Centre. With support from CIHR, CFI, BCKDF, and Amorfix Life Sciences, Dr. Cashman is conducting basic research on immunotherapies and vaccines to protein misfolding diseases, especially ALS. Dr. Cashman enjoys active collaborations with his UBC basic science colleagues in the Department of Physics and Astronomy, including Drs. Andre Marziali, Steve Plotkin and Ian MacKay, and neuropathology collaboration with Dr. Ian McKenzie at VGH. Dr. Cashman and ALS Centre colleagues have recently had approved a protocol to collect ALS tissue, blood, and spinal fluid for research purposes. Training opportunities are abundant across the team, in addition to a newly approved Clinical and Research Fellow position provided by ALSBC in cooperation with the ALS Centre.

Neuro-Oncology Program Faculty: The Neuro-Oncology program is a multidisciplinary program involving members of the Divisions of Neurology, Radiation Oncology, Neurosurgery and Medical Oncology. Its goal is to provide comprehensive care for patients with CNS malignancies and establish both clinical and translational research programs in Neuro-Oncology.

Clinical Activities: In the realm of patient care, the program has continued to supply patients with advanced surgical and radiotherapeutic management of brain tumors including a well- established linear accelerator based stereotactic radiation program. Molecular diagnostic technology has advanced understanding of oligodendrogliomas and improved the management and chemotherapeutic strategies for these tumors.

Research Activities: Over the 2007 year, grant supported research into molecular genetic changes in oligodendroglioma and other gliomas was completed with grant support from the Brain Tumour Foundation of Canada. We completed a trial of dose intensive temozolomide in glioblastoma(RESCUE trial). Ongoing clinical research trials include a phase III trial comparing radiotherapy to temozolomide chemotherapy in low grade gliomas (NCIC CE5). A phase I / II clinical trial of RAD001C, a mTOR inhibitor, in glioblastoma multiforme is also underway. Currently, there is a working group with the BCCA Genome Science Centre and the University of Calgary to perform high throughput gene sequencing in oligodendrogliomas. The utility of MGMT methylation analysis in predicting response to therapy in glioblastoma is being evaluated.

Neuro-Ophthalmology Program Faculty: There are 5 staff neuro-ophthalmologists including Duncan P. Anderson, Maryam Aroichane, Jason J.S. Barton, Janette I. Lindley, N. Kevin Wade. There are 5 adjunct clinical staff: Ray Bell, Victoria; David Neima, New Westminster; David Nelson, Langley; Briar Sexton,

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Vancouver and David Wakelin, DuncanThe program welcomed a new faculty member, Maryam Aroichane, from the Université de Montréal, who will direct pediatric neuro-ophthalmology.

Clinical Activities: The Neuro-ophthalmology program provides clinical teaching and research services at Providence Health Care (St. Paul’s Hospital site) and VHHSC (Eye Care Centre) and UBC Hospital. Consulting services are also provided at GF Strong Rehab and BC Children’s Hospital. There are two satellite MS/neuro-ophthalmology clinics, one every 2 months at Burnaby staffed by Duncan Anderson, and one monthly at the Royal Jubilee Hospital in Victoria staffed by Ray Bell (director), Jason Barton, and David Wakelin.

Research Activities: There were 29 research presentations, 7 invited research lectures, 12 clinical lectures, and 49 articles or chapters published or in press at the time of this report. Research highlights included being profiled in UBC Reports, the Toronto Globe and Mail, and the Faculty of 1000 Biology. Dr.Duncan Anderson’s interest in the visual effects of Parkinson’s disease was highlighted in Ocular Surgery News.

Teaching Activities: The educational outreach of the program included a variety of key activities. There was another successful UBC Neuro-ophthalmology Clinical Day, with Fiona Costello of the University of Calgary and Randy Kardon of the University of Iowa as invited guest faculty. The educational website operated by the division continues to be well used, receiving 476,497 hits and 42,235 visits in the last 12 months.

Pacific Parkinson’s Research Centre Clinical Activities: The Movement Disorders Clinic provided approximately 3,500 outpatient visits in 2007. The majority of these were for patients with Parkinson’s disease or focal dystonia. The program continues to be heavily supported by nurse coordinators, who provide education and counseling to patients, families and other health care professionals. A Centre of Excellence award from the National Parkinson Foundation (Miami, Inc.) with additional support from the Parkinson Society Canada supported part-time physiotherapist and social worker.

Research Activities: In 2007, Centre investigators continued to receive support through a CIHR Team grant in Parkinson’s Disease ($4.45M over 5 years, beginning 2006) and a Research Unit award from the Michael Smith Foundation for Health Research ($800K over 4 years, starting 2006). Additionally, working together with other UBC investigators in the dementia program (Drs. Feldman and Mackenzie) and collaborators at the Mayo Clinic Jacksonville, PPRC investigators were awarded a Centre grant (the only one awarded) from the Pacific Alzheimer Research Foundation on Overlap Syndromes resulting in Dementia valued at more than $7M over 5 years (PI Stoessl). Investigators also received additional CIHR operating grants on Depression in Parkinson’s disease (PI Stoessl) valued at > $850,000 over 5 years and on Radiolabeling of Oligonucleotides (PI T. J. Ruth) valued at >$570,000 over 5 years. Centre investigators had 26 PubMed listings during 2007, including papers in Annals of Neurology, Brain, Journal of Cerebral Blood Flow & Metabolism and Lancet.

Teaching Activities: The Movement Disorders Clinic also provides ambulatory teaching to medical students and to residents in neurology, geriatrics, psychiatry and family medicine. During 2007, there were 3 clinical fellows working in the Centre. Faculty members of the Pacific UBC Department of Medicine Page 128 Annual Report 2007

Parkinson’s Research Centre participate in the Brain & Behaviour course and provide training to multiple trainees at the MSc. and PhD levels in the Graduate Neuroscience program. Dr. McKeown continues to run the Motor Systems module of the Systems Neuroscience (Neuroscience 501) core course in the Graduate Neuroscience program. Faculty members within the Centre serve as mentors in the CIHR-funded Neuroscience Training Initiative and serve on numerous supervisory, comprehensive and examination committees.

Epilepsy Program Faculty: Dr. Tiffany Townsend's arrival provided renewal to the Surgical Investigation Unit this year as she replaced Dr. M. W. Jones who had led the program previously. She joins Dr. Mano Javidan who continues his work as Director of the EEG Laboratory.

Clinical Activities: The inpatient seizure monitoring unit (SIU) is located on T5B at VGH. It is the solo adult epilepsy surgery program in British Columbia. In 2007 a total of 63 patients were monitored in the 2 bed SIU with 13 epilepsy surgeries performed and 2 with invasive monitoring. The technology within the SIU continues to advance with improved usage and accuracy of the seizure detection software. Extensive education is provided to the neurology nursing staff and patients/families by Janice Hendrickson, a skilled nurse practitioner. This year also witnessed the transition to a fully integrated integrated hospital clinic for epilepsy patients.

Research Activities: Dr. David Katz, received research funding to continue his studies on the memory of facial emotion in patients with mesial temporal lobe epilepsy. Dr. Javidan has beena actively developing a program of clinical research spanning the rates of non-convulsive status epilepticus, the localization and prediction of seizures by computerized analyses, the characteristics of patients with temporal lobe epilepsy and surgery without interictal epileptic activity on EEG and the weighted value of interictal and ictal EEG activity in the surgical outcome of patients with temporal lobe epilepsy.

Teaching Activities: The Epilepsy Program plays a key role in the education of Neurology residents and fellows. Neurology residents spend at least 3 months of their residency on the EEG/ Epilepsy rotation where they interpret outpatient and inpatient EEGs, admit and are directly involved with the care of the patients admitted to SIU and those seen in the Epilepsy Clinic; all under our direct supervision. Dr Javidan and Townsend have both active in CME and also have served as experts on provincial and national committees.

Basic Neuroscience Research Program The Division’s basic neuroscience research is primarily conducted within the Brain Research Center at the UBC Campus. Areas of research include a focus on neuroimmunology, neurovirology and neurochemistry.

The long-standing research interest in Dr. Yu Tian Wang’s laboratory has been on understanding fundamental mechanisms controlling communications among neurons in the brain, with particular relevance to the pathogenesis of brain disorders such as stroke and learning deficits. His laboratory continued to attract major recognition for its outstanding contribution to basic neuroscience research nationally and internationally. Dr. Wang has developed an NR2B-derived peptide as an anti-excitotoxicity based stroke therapy, that has recently completed a phase 1 trial.

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The results showed that the predicted efficacy dose of the peptide was well-tolerated by human subjects. Initiation of the Phase 2A trial is planned for this fall.

Beyond the research on stroke, the Wang lab also continued their investigations on learning and memory and how alteration of these mechanisms contributes to some of the memory deficits caused by brain diseases or stress. New discoveries include the elucidation of mechanisms underlying memory retrieval impairment by acute stress (PNAS, 104:11471, 2007), and retention of fear memory (Neuropsychopharm. In press). These results are particularly relevant to memory deficits in humans following acute psychological stress and fear memory retention associated with post-traumatic syndromes.

The labs of Drs. Steven Pelech, Joel Oger, Lorne Kastrukoff, Neil Cashman, Peter Rieckmann, contribute to divisional reach in basic neuroscience research.

Appointments and Promotions

Dr. Clauda Jacova was appointed as Assistant Professor with effect from July 1, 2007.

Dr. Judy Illes was appointed as Professor and Canada Research Chair Tier I in Neuroethics with effect from August 1, 2007.

Dr. Peter Rieckmann was appointed as Professor and MS Chair with effect from September 1, 2007.

Dr. Sian Spacey was provisionally appointed to the rank of Clinical Associate Professor with effect from January 1, 2008.

Dr. Anthony Costantino was promoted to the rank of Clinical Assistant Professor from Clinical Instructor with effect from July 1, 2007.

Dr. Colleen Murphy was promoted to the rank of Clinical Assistant Professor from Clinical Instructor with effect from July 1, 2007.

Special Honours and Awards

Dr. Jason Barton received the Martin M Hoffman Award from the UBC Department of Medicine for Excellence in Research. He served as the Royal College of Physicians and Surgeons Lecturer, Université Laval, Québec, Jan 07 and Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, April 2007. His students and trainees have been very successful in 2007 as well. Kirsten Dalrymple received the CPA Certificate of Academic Excellence for best UBC Masters thesis in psychology. Natashka Pollock received the Resident research award at UBC ophthalmology Research Day, and Chris Waite received the G Milton Shy medical student essay award for clinical neurology from the American Academy of Neurology.Kirsten Dalrymple, Chris Fox and Giuseppe Iaria received salary awards from MSFHR, and Giuseppe Iaria received a fellowship from the Canadian Alzheimer’s Society. The Neuroopthalmology program under his leadership now holds 25 grants in the amounts $3,485,653.

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Dr. Neil Cashman achieved an International Partnership Initiative Award, NCE ($ 425,000/yr X 2 yrs) to enable PrioNet Canada to participate in international collaborations in Europe and North America, including joint meeting and training opportunities.

Dr. Doris Doudet was awarded a Guest Professorship at the University of Aarhus, Denmark.

Dr. Armin Curt was appointed Scientific Director of the Spinal Cord Injury - Translational Research Network (SCI-TRN) of Canada and Lead of the Rehabilitation Network. The network is funded by the Canadian Federal Government with a budget of $30 million CAD (2007-2012) provided to the Rick Hansen Foundation.

Dr. Mano Javidan served as President of the Canadian Society of Clinical Neurophysiology.

Dr. Tiffany Townsend served as a member of the Professional Advisory Committee for the BC Epilepsy Society and has developed information sheets and given public lectures this year on its behalf.

Dr. Jeff Martzke was awarded the Parke O. Davidson Award for excellence in research, training and clinical practice of Psychology by the British Columbia Psychological Association

Dr. Judy Illes was selected to present the Tanner Lecture on Human Values, Cambridge University, Cambridge, UK and as Chair, Women in World Neuroscience, International Brain Research Organization (IBRO)

Dr. Martin McKeown was awarded a Michael Smith Team Grant to lead an interdisciplinary project that will utilize advances in biosignal processing, bio-electrodes, probably-safe control methods and wearable computer technology to detect, monitor -- and ultimately manage -- disrupted brain activity that is a hallmark of Parkinson's disease.

Dr. Joel Oger served as Chair of the Safety Monitoring Boards of several large international randomized clinical trials. He was an invited keynote speaker at the University of Chicago in June 2007 and at the CONY Controversies in Neurology Berlin September 6 -9 2007. He received formal recognition and approval of his laboratory as a diagnostic facility under Ministry of Health of British Columbia under the name "Neuro-Immunology Laboratories".

Dr. Gordon Robinson was appointed as Medical Director for Vancouver Acute for Rehabilitation, Arthritis, Spine and Neurosciences.

Dr. Vesna Sossi was awarded a Michael Smith Foundation for Health Research Career Senior Scholar Award 2007-2012 as well as a Peter Wall Senior Early Scholar award 2006/07.

Dr. Sian Spacey was appointed as Director of the UBC Clinical Investigator Program and as a Member of the Royal College of Physicians and Surgeons of Canada (RCPSC) Nucleus Committee for clinical investigator programs.

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Dr. Blair Leavitt contributed as a member of the Organizing Committee for the World Congress of Huntington’s Disease, WFN & IHA Germany, September 2007 and the Program Committee of the CAG Triplet Repeat disorders, Gordon Research Conference, France 2007.He has been appointed as a Co-Organizer, World Congress of Huntington’s Disease, WFN& IHA Vancouver, September 2009. He was awarded both a Michael Smith Foundation for Health Research MSFHR Career Investigator (Scholar) Salary Award as well as a Clinician-Scientist Phase II Salary Award Canadian Institutes of Health Research. He received funding for TRACK-HD a multi-centre, multinational prospective observational study in Huntington’s disease. 3 years = $1,355,505.00. He was awarded a MSFHR Career Investigator Salary Award – Scholar, (Michael Smith Foundation for Health Research) and a Clinician-Scientist Phase II Salary Award, (Canadian Institutes of Health Research)

Dr. Virginia Devonshire, along with Dr Paul O'Connor from the University of Toronto have developed revised national guidelines for the treatment of MS with currently available therapies.

Dr. Jon Stoessl was awarded with membership in the Order of Canada. He was renewed as a Canada Research Chair Tier 1. He served as the Bundy Professorship at Mayo Clinic and was re- selected as one of the Best Doctors in Canada.

Dr. Howard Feldman's research and career were profiled in Lancet Neurology 2007 6 (6) 482. He was awarded the inaugural Fisher Family and Alzheimer Society of British Columbia Endowed Professorship in Alzheimer's disease research and was re-selected as one of the Best Doctors in Canada. He served as the convening co-chair of the 4th Canadian Colloquium on Dementia in Vancouver, the premier Canadian event that brings together clinicians and researchers involved dementia.

Dr. Claudia Jacova was co-author on a paper in Lancet Neurology proposing new research diagnostic criteria for Alzheimer's disease that was the most downloaded through Science Direct between July and October 2007.

Dr. Helen Tremlett was awarded a CIHR operating grant to study malignancy in MS in consideration of the impact of beta interferon. She also had a successful grant application to the US National MS Society to study whether relapses affect disease progression in MS. She was successful in competitions for salary awards from the Michael Smith Heath Research Foundation (Scholar Award) and also was honoured with the Don Paty Career Development Award. She received the Jacqueline Du Pre Grant from the Multiple Sclerosis International Federation's (MSIF) Scientific Programmes Committee (International Medical & Scientific Board) to fund a four-month placement at the Menzies Research Institute, University of Tasmania, Australia.

Dr. Dessa Sadovnick was the recipient of a large grant from the MS Society of Canada Scientific Research Foundation to continue the Canadian Collaborative Project on Genetic Susceptibility to MS and is also a co-investigator on a grant to study the conversion from clinically isolated syndrome to pediatric MS. She has initiated a Multiple Sclerosis North American Pregnancy Program.

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Dr. Peter Rieckmann was elected as the Director of the Pacific Region for the EndMS Initiative of the Canadian MS Society. His appointment at UBC includes being the inaugural Endowed Multiple Sclerosis Society of Canada Research Chair

Dr. Yu Tian Wang received new CIHR operating grant funding to investigate AMPA receptors as well as funding through the CIHR China-Canada Joint Health Research Initiative to study the role of hippocampal synaptic plasticity and protein. He was the recipient of continued support from the Howard Hughes Medical Institute as an International Scholar

Dr. Anthony Traboulsee appointed as Member at Large, Consortium of MS Centers Board of Directors; Co-chair, Fellowship Committee, Canadian Network of MS Centers; Vice-President, Canadian Network of MS Centers and VGH Neuroplex Committee member

Publications by Fellows/Students/Residents

IARIA, Giuseppe 1. Bohbot VD, Lerch J, Thorndycraft B, Iaria G, Zijdenbos AP. Gray matter differences correlate with spontaneous strategies in a human virtual navigation task. J Neurosci 2007;27: 10078-83.

2. Doricchi F, Iaria G, Silvetti M, Figliozzi F, Siegler I. The "ways" we look at dreams: evidence from unilateral spatial neglect (with an evolutionary account of dream bizarreness). Exp Brain Res 2007;178:450-61.

3. Iaria G, Chen JK, Guariglia C, Ptito A, Petrides M. Retrosplenial and hippocampal brain regions in human navigation: complementary functional contributions to the formation and use of cognitive maps. Eur J Neurosci 2007;25:890-9.

4. Iaria G, Chen JK, Guariglia C, Ptito A, Petrides M. Retrosplenial and hippocampal brain regions in human navigation: complementary functional contributions to the formation and use of cognitive maps. Eur J Neurosci 2007;25:890-9.

5. Iaria G, Robbins S, Petrides M. Three-dimensional probabilistic maps of the occipital sulci of the human brain in standardized stereotaxic space. Neuroscience 2007 Nov epub.

6. Iaria G, Committeri G, Pastorelli C, Pizzamiglio L, Watkins KE, Carota A. Neural activity of the anterior insula in emotional processing depends on the individuals' emotional susceptibility. Hum Brain Mapp 2007 Apr epub.

SAYAO, Ana-Luiza 1. Sayao AL, Devonshire V, Tremlett H. Longitudinal Follow-up of Benign MS at 20 years. Neurology. 2007 Feb 13;68(7):496-500.

2. Tremlett HL, Sayao AL, Devonshire V. Longitudinal follow-up of ‘benign’ multiple sclerosis at 20 years. Neurology 2007;69(9):938.

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PHYSICAL MEDICINE & REHABILITATION

Dr. Andrea Townson Dr. Theo Van Rijn Clinical Assistant Professor & Head Clinical Associate Professor & Head (Nov 1, 2007 - present) (Jan 1 – Oct 31, 2007)

Faculty Members

Clinical Associate Professor & Head van Rijn, Dr. Theo VA Clinical Associate Professor Anton, Dr. Hubert VA Clinical Associate Professor Hahn, Dr. George VA Clinical Associate Professor Schamberger, Dr. Wolfgang Burnaby Clinical Associate Professor Travlos, Dr. Andrew VA Clinical Associate Professor Krassioukov, Dr. Andrei VA Clinical Assistant Professor Baruni, Dr. Rida VA Clinical Assistant Professor Dhawan, Dr. Pankaj VA Clinical Assistant Professor Hirsch, Dr. Gabriel VA Clinical Assistant Professor Hughes, Dr. Barbara VA Clinical Assistant Professor Koo, Dr. David VA Clinical Assistant Professor Mortifee, Dr. Peter VA Clinical Assistant Professor & Head Townson, Dr. Andrea VA Clinical Assistant Professor Underwood, Dr. Heather VA Clinical Assistant Professor Vondette, Dr. Michael VA Clinical Assistant Professor Weeks, Dr. Claire VA Clinical Assistant Professor Weiss, Dr. Elliott SPH Clinical Assistant Professor Yao, Dr. Jennifer VA Clinical Assistant Professor Guzman, Dr. Jaime Vancouver Clinical Assistant Professor Filby, Dr. James Victoria Clinical Assistant Professor MacKean, Dr. Lynne Victoria Clinical Instructor Adrian, Dr. Mark VA Clinical Instructor Crossman, Dr. Mark Vancouver Clinical Instructor Dawson, Dr. Andrew VA Clinical Instructor Lau, Dr. Herman SPH

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Clinical Instructor O'Connor, Dr. Russell VA Clinical Instructor Reebye, Dr. Nittin VA Clinical Instructor Willms, Dr. Rhonda VA Clinical Instructor Finlayson, Dr. Heather VA Clinical Instructor Nguyen, Dr. Viem SPH Clinical Instructor Reebye, Dr. Rajiv VA Associate Member Purtzki, Dr. Jacqueline VA Associate Member Eng, Dr. Janice Vancouver Associate Member Miller, Mr. William VA Associate Member Yassi, Dr. Annalee Vancouver Honorary Professor Kaplan, Dr. Paul USA Honorary Member Weeks, Dr. Claire VA Professor (Emeritus) Murray, Dr. Duncan Clinical Professor (Emeritus) Robinson, Dr. Cecil Clinical Associate Professor (Emeritus) Pinkerton, Dr. Alexander

Divisional Overview

The UBC Division of Physical Medicine & Rehabilitation currently has 31 active faculty members who are involved with patient care, teaching and research. Our members consult and provide rehabilitation services to persons ranging from the very young to the very old. We manage inpatient and outpatient programs for persons who have suffered spinal cord injury, acquired brain injury, neuromuscular abnormalities and cardio/pulmonary dysfunction. Inpatient services are provided at several sites, including Vancouver Acute/GF Strong Rehab Centre, St. Paul’s Hospital, Holy Family Hospital, Eagle Ridge Hospital, Sunny Hill Health Centre, as well as consultation services to the Vancouver teaching hospitals, BC Children’s Hospital, Royal Columbian Hospital and Burnaby General Hospital. Our staff is actively involved in teaching residents and medical undergraduate students, as well as undergraduate students in related disciplines. Research activity deals with disease specific issues related to our patient population, as well as disability issues for the population at large.

Teaching

Undergraduate Dr. David Koo continued to serve as the Undergraduate Coordinator for the Division.

We continue to provide a strong presence with MSK skills preceptorship during the 2nd year MSK skills series, in conjunction with the Divisions of Orthopedic Surgery and Rheumatology at VGH site. Six Division members participated in the teaching for the 2007/2008 year.

GF Strong has continued to participate in 2nd year bedside clinical skills teaching, with the capacity of taking 2 students per block, for the 4 potential blocks.

UBC elective/selective requests have come from 17 medical students with 11 from out-of- province students and 6 from UBC students for the 2007/2008 year.

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Undergraduate involvement of PM&R in the 3rd year Internal Medicine half-day lecture series now reflects the new 1 hour format of these lectures and works within the new teleconferencing structure of the satellite sites. The objectives for this lecture include the WHO-sanctioned definitions of impairment, activity and participation, as per the International Classification of Function.

The Undergraduate Committee meets quarterly to discuss Undergraduate teaching issues and future service provision.

Postgraduate Dr. Jennifer Yao stepped down as Residency Program Director in 2007. Dr. Heather Finlayson is the new Program Director and continues to build on the successes achieved by Dr. Yao. Under Dr. Yao’s leadership the Residency Program grew academically and is currently recognized as a premier program in the country.

There were nine active residents in the program at the end of 2007. The Division also provides regular teaching to residents in Neurology and Geriatrics as well as for resident electives from other UBC and external programs.

All residents from PGY2 onwards have a weekly formal half-day of research experience throughout their academic years. Resident teaching is done at the bedside and in ambulatory clinics. Formalized seminars are undertaken during weekly Academic Half Days as well as selected times throughout the week. The resident academic half-day schedule has been updated to follow a systems/disability-based approach. We are designing a new education program for the teaching of chemodenervation and joint injection techniques in conjunction with gross anatomy and simulators. We are working with Dr. Lyle Gross of the University of Otago, New Zealand to develop a joint UBC/University of Otago seminar series on Medical Legal assessments. This will be offered to all residents and potentially staff as a CPD activity.

All residents now participate in a yearly Quality Improvement project and all residents are involved in research. Resident research topics include: Disability supports for Aboriginal populations in rural communities; Correlation of piriformis syndrome provocation tests with CT- guided injection; Impact of autonomic dysfunction in the classification system for disabled athletes; Prevalence of fatigue in patients with traumatic brain injury; Use of acupuncture for pain in spinal cord injury; Type and frequency of injuries in Paralympic sledge hockey.

Continuing Professional Development

Dr. Russell O’Connor continued as our Continuing Professional Development Coordinator. The Division provides needs-based weekly CPD meetings attended by Division and non-Division members who have an interest in topics presented. The CPD Committee meets at least bi- annually to review upcoming CPD activities and to formulate ways to enrich ongoing education of our membership. The CPD committee continues to encourage members to develop innovative teaching methods, as well as utilizing panel discussions and experts from other sub-specialties for broader educational experience.

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Dr. Jaime Guzman has taken over the coordination of the scheduled monthly Division Journal Club. His research background and leadership are welcome additions.

Research

Dr. Andrei Krassioukov became the Division Research Director and Chair of the Division Research Advisory Committee in 2007. Dr. Hugh Anton continued to serve as the GF Strong Research Coordinator. Division members have actively participated in regular research education sessions focused on the relevance of research to the professional development needs of the Division. Current areas of research development include use of therapeutic injections for the management of spasticity and pain; novel approaches to functional electrical stimulation in stroke; evidence based practice and interventions for spinal cord injury; and fatigue in neurological and neuromuscular disorders. The Division Research Advisory Committee continues to meet and develop a strategic planning process for research.

Dr. Hugh Anton is the co-leader of the interdisciplinary Fatigue and Function in Neurologic and Neuromuscular Disorders research team. Other Division members on the team include Dr. Andrea Townson and Dr. Barbara Hughes.

Dr. Andrei Krassioukov continues his internationally renowned research in autonomic dysfunction with several active research projects and graduate students under his supervision

Dr. Andrea Townson continues as a co-investigator on SCIRE. Spinal Cord Injury Rehab

Evidence available at www.icord.org/scire.

Dr. Barbara Hughes is the principal investigator of a project regarding bladder management following spinal cord injury as well as being co-investigator in another project dealing with genetic markers in recovery from spinal cord injury.

Dr. Russell O’Connor, Dr. Heather Finlayson, Dr. Andrew Travlos, Dr. Rajiv Reebye, Dr. Andrei Krassioukov and Dr. Jennifer Yao are actively involved in research on therapeutic injections with Botulinum Toxin, Phenol and Lidocaine.

Other active research areas include the Impact of Critical Illness Polyneuromyopathy in Rehabilitation (Dr. Heather Finlayson, Dr. Andrew Travlos, Dr. Russell O’Connor) and Upper Limb Outcomes in Stroke Subjects (Dr. Heather Finlayson)

Clinical Services

Members of our Division continue to provide consultation services to Vancouver Acute, St. Paul’s Hospital, as well as other hospitals in the Fraser Health Authority. Dr. Elliot Weiss is the leader for rehabilitation of Providence Health Care. Dr. Travlos and team members continue to provide clinical services and direction to the rehabilitation programs for persons suffering from ALS. Drs. Rhonda Willms and Heather Underwood participate in services for persons requiring orthotics and/or prosthetics. Dr. George Hahn and Dr Jacqueline Purtzki provided consultation

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services for the BC Children’s Hospital, Vancouver Acute, and Sunnyhill Health Center. Drs. James Filby and Lynne MacKean are providing UBC Undergraduate teaching assistance in Victoria.

Dr. George Hahn retired in 2007. Dr. Hahn’s clinical expertise was in pediatric and adolescent physiatry. His many contributions to the Division over the years were appreciated and his presence on the clinical wards will be missed.

Administration

After 5 years as Division Head, Dr. Theo van Rijn stepped down. He continues to be involved actively in Division teaching activities. Under Dr. van Rijn’s leadership, the Division grew clinically and academically. Research activity and productivity have increased significantly and the Division is recognized nationally as a leader in clinical and teaching activities.

Dr. Andrea Townson is the new Division Head.

Dr. Jennifer Yao is the Co-chair of Stroke Rehabilitation and community reintegration workgroup for the Provincial Stroke Strategy, the Vice chair for the Education Committee for the CAPMR and a Member at Large for the CAPMR executive.

Dr. Heather Underwood is the leader for the amputee special interest group for the CAPMR. Dr. Andrea Townson is the leader for the spinal cord injury special interest group for the CAPMR.

Dr. Andrew Travlos served as a Chair of Specialty Committee in Physical Medicine & Rehabilitation of the Royal College of Physicians and Surgeons of Canada.

Dr. Hugh Anton served as examiner for the Specialty of PM&R at the Royal College.

Dr. Gabriel Hirsch served as Chair of the Section of PM&R for the BC Medical Association.

Dr. Rida Baruni stepped down as the Medical Director of Rehabilitation and Ambulatory Care Services, Vancouver Acute – Vancouver Coastal Health. Dr. Andrea Townson has been appointed as the medical site leader for GF Strong Rehab Centre, Vancouver Acute. Drs. Andrea Townson, Andrew Travlos, and Jennifer Yao served as medical managers assisting in program related issues at G.F. Strong Rehabilitation Centre.

The Division continues to provide leadership for the 2010 Paralympics. Dr. Russell O’Connor is the Medical Manager for the 2010 Paralympics, Vancouver Olympic Committee. Dr. Heather Underwood is a venue medical officer for Nordic skiing and Dr. Andrea Townson is a venue medical officer for Alpine skiing

Future Directions

The opening of the ICORD building in 2008 is expected to foster further interdisciplinary collaboration, research and clinical activities focused on spinal cord injury research.

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Teaching and medical education have always been key strengths for the Division. With Division members pursuing formal training in education (Drs. Jennifer Yao and Heather Finlayson), the Division is poised to take a national leadership role in medical education and physiatry. The Division has begun to co-develop a Canada-wide post-graduate education/teaching initiative to promote academic excellence in our specialty.

The distributed medical school sites provide an opportunity for our Division to build further on our clinical and academic ties throughout the province. The Division is working on recruiting a new member to provide clinical and academic ties to Northern British Columbia.

The Division continues to develop long-term initiatives regarding rehabilitation education and research in overseas countries.

Special Honours and Awards

Dr. Jennifer Yao was awarded the Theo van Rijn Award for Contributions to the Residency Program in 2007.

Dr. David Koo was the recipient of the 2007 Duncan Murray Award for Excellence in Teaching.

Dr. Theo van Rijn received the 2006 PAR-BC Dr. Patricia Clugston Memorial Award for Excellence in Teaching.

Dr. Hugh Anton was awarded the 2007 Best Annual Physical Medicine and Rehabilitation City Wide Rounds Presentation for his presentation on ‘Research Catastrophes’.

Dr. David Koo was the Keynote speaker for the BC Rehab Foundation Standing Ovation Awards Ceremony, Vancouver, BC, October 17, 2007.

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RESPIRATORY MEDICINE

Dr. J. Mark FitzGerald Professor & Head

Faculty Members

Professor Fitzgerald, Dr. J. Mark VA Professor Bai, Dr. Tony SPH Professor Duronio, Dr. Vincent VA Professor Fleetham, Dr John VA Professor Lam, Dr. Stephen VA Professor Levy, Dr. Robert SPH Professor Man, Dr. S. F. SPH Professor Ostrow, Dr. David VA Professor Pare, Dr. Peter SPH Professor Road, Dr. Jeremy VA Professor Ryan, Dr. Francis (Frank) VA Professor Van Eeden, Dr. Stephanus SPH Associate Professor Ayas, Dr. Najib VA Associate Professor Sandford, Dr. Andrew SPH Associate Professor Sin, Dr. Donald SPH Associate Professor Ward, Dr. Helen VA Associate Professor Wilcox, Dr. Pearce SPH Assistant Professor Cook, Dr. Victoria VA Assistant Professor Swiston, Dr. John VA Assistant Professor Tebbutt, Dr. Scott SPH Clinical Professor Khalil, Dr. Nasreen BCCDC Clinical Professor Lawson, Dr. Lindsay SPH Clinical Professor Nakielna, Dr. Edina (Barbara) SPH Clinical Associate Professor Elwood, Dr. Richard BCCDC Clinical Assistant Professor Carlsten, Dr. Christopher VA Clinical Assistant Professor Cohen, Dr. Richard North Vancouver Clinical Assistant Professor Fera, Dr. Tharwat VA Clinical Assistant Professor McWilliams, Dr. Annette BCCRC Clinical Assistant Professor Turner, Dr. Mark VA Clinical Assistant Professor Wilson, Dr. Jennifer VA

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Honorary Professor Lertzman, Dr. Morley VA Honorary Professor Tan-Hogg, Dr. Wan SPH Associate Member Brauer, Dr. Michael VA Associate Member Lowe, Dr. Alan Associate Member Muller, Dr. Nestor Associate Member Roberts, Dr. Clive SPH Professor (Emeritus) Abboud, Dr. Raja VA Professor (Emeritus) Yeung, Dr. Moira VA Clinical Professor (Emeritus) Allen, Dr. Edward Clinical Professor (Emeritus) Champion, Dr. Paul VA Visitor Tamagawa, Dr. Eiji SPH Visiting Scientist Petchkovski, Dr. Dmitri SPH

Divisional Overview

The UBC Respiratory Division is primarily located at the major teaching hospitals affiliated with the UBC Faculty of Medicine. The major activities are focused at Vancouver General Hospital, St. Paul’s Hospital and UBC Hospital. In addition, reflecting the distributed medical school there are a now a significant number of community respirologists affiliated formally as either full or associate members of the Division. Dr. FitzGerald is the Head of the UBC Respiratory Division as well as the VGH Respiratory Division. Dr. Jeremy Road is the Associate Director of the UBC and VGH Respiratory Divisions which is a new position created in 2007 to allow Dr. FitzGerald focus on major strategic directions. Dr. Bob Levy completed his term as Head of Respiratory Medicine in September 2007, after over five years dedicated service, which saw a significant improvement in the ambulatory care capacity at SPH, with the development of the Pacific Lung Health Centre. Dr. Tony Bai has assumed the Headship at SPH in October 2007. The clinical services provided by the Division are outlined below. A major new initiative at SPH in 2007 was the announcement of the Providence Heart and Lung Institute at SPH. This new structure will seek to consolidate cardio respiratory services from basic research through to improved models of clinical care delivery for both heart and lung diseases. It builds on the established strengths of a number of current programs at SPH including iCAPTURE and the Heart Centre at SPH as well as the Pacific Lung Health Centre. In addition in 2007 the UBC Respiratory Division developed a multi site lung health framework focusing on education, clinical care and research. The Centre for Lung Health will provide a broader framework for a Lung Health Initiative originally conceived in 2006.

In 2007 there were two key recruitments to the Division. Dr. John Swiston returned from Harvard University where he completed training in clinical epidemiology, after a year of clinical training in pulmonary hypertension in Toronto. He has now assumed the position as Medical Director of the Provincial Pulmonary Hypertension Program with ongoing collaboration with Drs. Levy and Ostrow. In addition he participates in general respiratory medicine at VGH. After many years of attempting to recruit a replacement for Dr. Moira Chan Yeung, the Division was successful in recruiting a superbly trained occupational lung disease investigator Dr. Chris Carlsten. Dr. Carlsten has assumed the role of medical Director of the Occupational Lung Disease Clinic at The Lung Centre at VGH. He is currently establishing his own research laboratory and strengthening links with many other UBC affiliated investigators most notably at the School of Environmental Health, iCAPTURE and also at SFU. Dr. Carlsten’s recruitment was made possible through the UBC Department of Medicine Page 142 Annual Report 2007

$2 million Astra Zeneca Chair in Occupational and Environmental Lung Disease as well as a generous contribution made by Dr. Moira Chan Yeung.

Teaching

• Undergraduate: Dr. Jeremy Road (VGH) and Dr. Tony Bai (SPH) coordinate undergraduate elective programs for medical students. In this regard, the increased size of the medical school, has presented new opportunities and challenges. Dr. Richard Cohen has assumed responsibility for the PBL pulmonary block and brings specialty expertise in education to this role as well as his specialty training in Respiratory Medicine.

• Postgraduate: Dr. Jen Wilson is the Program Director for the Respiratory Medicine post graduate training program. The program received full accreditation in the Royal College Review of Specialty Post graduate programs in 2007. The Program has expanded significantly with currently 7 clinical fellows in the program. The increased number of fellow’s has created new opportunities for a greater range of specialty elective rotations both with the traditional teaching hospital locations but also in many community hospitals. Dr. Pare continues to lead the IMPACT training program which is a CIHR funded training program designed to develop a critical mass of scientists researching in the respiratory domain. Many Divisional members have cross affiliations with other CIHR funded trainee programs. These include TRID (Translational research in Infectious Diseases) FitzGerald and CIHR funded trainee program in transplantation (FitzGerald)…. Many Divisional members are primary or co supervisors of Master’s, Ph D and post Doc students in a wide range of trainee programs across many different disciplines….

• Experimental Medicine: Dr. Vince Duronio, is the director of the Experimental Program, as well as a Divisional member. In total there are 17 fellows, 16 PhD students, 9 Master's students affiliated with the respiratory Division.

• Continuing Medical Education: Divisional members contribute extensively on a Provincial, National and International level to professional development. The scope of these contributions, are too abundant to list in this brief report but reflect the major productivity of the Division in terms of Research activity as outlined below. It also reflects the major contributions members have continued to make in terms of national and international guideline development in many therapeutic areas. The major Divisional activity is the UBC Respiratory Medicine Update which again was a very successful meeting co sponsored with the BC Lung Association and held in Vancouver in March 2007.

Research

The UBC Division has an international reputation for excellence in research which spans the CIHR Pillars from state of the art basic research through to health outcomes. A conservative estimate of dollars generated for lung related research within the Division for 2007 comes to $16 million. Major peer reviewed publications totaled over 200 papers for 2007 either published or in press. The iCAPTURE Centre for Cardiovascular and Pulmonary Research at SPH continues to

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provide strong leadership in basic and translational research with a particular focus on airways disease and cystic fibrosis but also an emerging emphasis on interstitial lung disease. Divisional members based in iCAPTURE include Scott Tebutt and Andy Sandford, focused on genetic mechanisms of lung disease; Don Sin, Wan Tan and Stephan Van Eeden, focused on COPD and air pollution; and Paul Man and Peter Pare both share multiple pulmonary research interests. Basic research also occurs at The Lung Centre at VGH with strong leadership from Drs. Vince Duronio and Nasreen Khalil but its major emphasis continues to be clinical and epidemiologic research focusing on sleep disordered breathing, interstitial lung disease (both clinical and basic), airways diseases, occupational lung diseases and tuberculosis. There is major collaborative lead between VGH based investigators and the BC Cancer Agency focusing on better understanding of the pathogenesis, prevention and management of lung cancer. Drs. Stephen Lam and Annette McWilliams provide leadership for this program. Health outcomes research has been facilitated by MSFHR funding of a Sleep Research Unit with a number of economic evaluations completed in the sleep disordered breathing domain. A broader development of this program has been facilitated by the joint award of a $1 million grant to Drs. Carlo Marra and FitzGerald for the development of a Respiratory Evaluation Program (RESP). It’s anticipated that these funds will facilitate the recruitment of both a PhD and Master’s level health economist focusing entirely on respiratory health outcomes with a special emphasis on respiratory health economics. This development is facilitated by the ongoing collaboration between the Centre for Health Outcome Evaluation Sciences (CHEOS at SPH) and the Centre for Clinical Epidemiology and Evaluation (C2E2) based at VGH.

Clinical Services

The UBC Division provides tertiary and quaternary services in a distributed model with regional and provincial services in pulmonary transplant (Medical Director Dr. Levy), pulmonary hypertension (Director, Dr. John Swiston), chronic home ventilation program (Director Dr. Jeremy Road), occupational lung diseases (Director Dr. Chris Carlsten) and Tuberculosis Ward (Director Dr. Mark FitzGerald) based at VGH. Other specialty clinics at VGH include COPD ( Dr. Road et al), Asthma (Dr. FitzGerald), Interstitial Lung Disease( Dr. Khalil) , lung cancer (Drs. McWilliams and Lam) and pleural diseases ( Dr. Ryan et al). The Provincial cystic fibrosis program (Director, Dr. Barbara Nakielna) is based at SPH where there is also specialty expertise in pulmonary complications of HIV with links to the BC Centre for Excellence in HIV. SPH has specialty clinics for difficult asthma, pulmonary complications of scleroderma, interstitial lung diseases and COPD. UBC Hospital is the site, for the regional program in sleep disordered breathing. Dr. Fleetham is the medical director of this program. Both sites provide comprehensive state of the art management across the continuum of care from ambulatory to acute, managing a broad range of respiratory diseases. In addition there is a respiratory consultation service provided to UBC Hospital, Mount St. Joseph’s Hospital, GF Strong and Pearson Hospitals. Both sites continue to develop ambulatory care related resources with an improved location for the Respiratory Ambulatory Unit at VGH, expanded pulmonary rehabilitation capacity at both major hospitals as well as innovative extension of care into the community best exemplified by an excellent program based at SPH with links to community rehabilitation. There are continued efforts to create better models of chronic disease management with COPD and asthma clinics continueing to evolve based on multi disciplinary models of care. Both sites have re constituted

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their Morbidity and Mortality Rounds and have been proactive in including fellows and trainees in this process. The latter involvement has facilitated quality assurance projects.

Administration

Ms. Bernice Robillard provides administrative support for the Post graduate training program. The UBC Divisional Secretary Position is currently vacant and it has been decided to develop a new job description for this position focusing more on program management and strategic direction with part time secretarial support.

Future Directions

The Division faces a number of major challenges but also great opportunities. A major focus will be to develop a strategic recruitment plan especially focusing on the imminent needs for a clinician scientist, with an interest in cystic fibrosis, to be recruited to SPH, as well as the need for additional clinical respiratory physicians at that site. The Division also needs to look more generally at manpower needs especially the impact of the abolition of mandatory retirement at UBC on anticipated practice patterns in the future. Physical space and infrastructure, most notably for research space at SPH, will be a major focus on Divisional related activities. Although The Lung Centre at VGH provides excellent clinical and research space, with recent recruitments and a major increase in general clinical research additional, space will be required on this site also.

The development of a virtual Centre for Lung Health will provide an opportunity for broader strategic planning looking at new opportunities for education, research and clinical care. The ability to leverage off this Province wide initiative, with site specific opportunities most notably the Providence Heart and Lung Institute at SPH, presents a unique opportunity to maximize funding sources especially of a philanthropic nature from hospital based Foundations as well as seeking priority within UBC’s broader fund raising campaigns.

Special Honors and Awards:

Dr. Stephan van Eden: MSFHR Senior Scholar

Dr. Don Sin: SPH Distinguished Achievement Award in the Excellence in Clinical and Applied Research

Dr. John Swiston: In it for Life Scientist Award VCHRI

Dr. Annette McWilliams: In it for Life Award VCHRI

Dr. Frank Ryan: Master Teacher Award Vancouver General Hospital

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RHEUMATOLOGY

Dr. Barry Koehler Dr. John Esdaile Clinical Professor Emeritus & Professor & Head Acting Head (Jan 1 – June 30, 2007) (July 1 – Dec 31, 2007)

Faculty Members

Professor Chalmers, Dr. Andrew VA Professor Esdaile, Dr. John VA Associate Professor Choi, Dr. Hyon VA Assistant Professor Cibere, Dr. Jolanda VA Assistant Professor Lacaille, Dr. Diane VGH Clinical Professor Blocka, Dr. Kenneth VGH Clinical Professor Reid, Dr. Graham VA Clinical Associate Professor Huang, Dr. Simon SPH Clinical Associate Professor Klinkhoff, Dr. Alice VA Clinical Associate Professor Offer, Dr. Robert Penticton Clinical Associate Professor Patterson, Dr. A. Caroline VA Clinical Associate Professor Shojania, Dr. Kamran VA Clinical Associate Professor Shuckett, Dr. Rhonda SPH Clinical Associate Professor Wade, Dr. John VA Clinical Assistant Professor Badii, Dr. Maziar VA Clinical Assistant Professor Ensworth, Dr. Stephanie VA Clinical Assistant Professor Kelsall, Dr. John SPH Clinical Assistant Professor Watterson, Dr. John VA Clinical Instructor Collins, Dr. David VA Clinical Instructor Fenton, Dr. Stanley RCH Clinical Instructor Gillies, Dr. Jean SPH Clinical Instructor Kur, Dr. Jason VA Clinical Instructor Wilk, Dr. Lucie VA

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Associate Member Kopec, Dr. Jacek Adjunct Professor LePage, Dr. Judy Vancouver Professor (Emeritus) Ford, Dr. Denys Clinical Professor (Emeritus) Koehler, Dr. Barry Richmond General Clinical Professor (Emeritus) Robinson, Dr. Harold Clinical Professor (Emeritus) Tsang, Dr. Ian VA

Divisional Overview

The UBC Division of Rheumatology currently consists of 24 active faculty members, one associate member, one adjunct member, and three emeritus members. Rheumatology consultation services are offered at Vancouver Hospital & Health Sciences Centre, St. Paul’s Hospital, BC Women’s Hospital & Health Centre, and G.F. Strong Rehabilitation Centre. Ambulatory care services are available at the Mary Pack Arthritis Centre, the Gordon and Leslie Diamond Centre, St. Paul’s Hospital, and in private practices throughout Metro Vancouver and Penticton. The Arthritis Society (BC & Yukon Division) provides excellent patient education and resources available through the Learning Centre based at the Mary Pack Arthritis Centre.

Many divisional faculty are members of the Arthritis Research Centre of Canada, a multidisciplinary clinical research and clinical trials facility affiliated with both the University of British Columbia and the Vancouver Coastal Health Research Institute. The Arthritis Research Centre focuses on "Practical Research for Everyday Living" for people with arthritis.

The two-year Postgraduate Training Program in Rheumatology continues to be the second-largest clinical rheumatology training centre in Canada. The program receives funding from the Ministry of Health for one trainee every year. Also, one or two internationally-funded trainees are considered. Active in-patient, ambulatory care and research training is done at Vancouver Hospital & Health Sciences Centre, St. Paul’s Hospital, G.F. Strong Rehabilitation Centre, the Arthritis Research Centre, and in private practices throughout the Lower Mainland and elsewhere in the province.

Dr. Jennifer Reynolds is a welcome new addition to the UBC Division of Rheumatology based at St. Paul’s Hospital, and will be starting a systemic lupus erythematosus clinic.

Dr. Lucie Wilk is a welcome new addition to the UBC Division of Rheumatology based at Vancouver Hospital & Health Sciences Centre where she has started a rheumatology clinic for general internal medicine residents.

Teaching

Dr. Simon Huang continues to direct the highly successful undergraduate rheumatology program. Dr. Rhonda Shuckett does a superlative job of leading the Rheumatology Problem-Based Learning for the second-year medical and dental class.

Dr. Kam Shojania has taken over as Program Director for the Postgraduate Training Program, and the hospital programs are led by Drs. Kenneth Blocka, John Wade, and John Watterson at St.

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Paul’s Hospital, Vancouver Hospital & Health Sciences Centre and G.F. Strong Rehabilitation Centre, respectively.

The postgraduate program is currently comprised of three first-year residents, two second-year residents, and four doctoral candidates. The clinical trainees continue to be involved in outreach clinics in Trail, Cranbrook, Fort St. John, Penticton and other rural communities throughout B.C. UBC provides partial support for travel and accommodation for these outreach clinics. The residents also participate in mandatory rotations at Vancouver Acute, St. Paul’s Hospital, G.F. Strong, BC Children’s Hospital, and in numerous drug/disease monitoring clinics and community rheumatology practices throughout their training.

For the seventh year, the “Basic Skills Course for Rheumatology Fellows” was given in the second week of September to provide detailed instruction on the clinical examination of the musculoskeletal exam, as well as the essentials of emergency arthritis care. The course, organized by Dr. Kam Shojania, involved the majority of the divisional faculty. Approximately 10 rheumatology trainees from other programs across Canada attended the course.

The clinical fellows have benefited from several weekly guest speakers from other divisions at their Academic Half-Day. Both the Division and the Postgraduate Training Program have enjoyed Noon Rounds presentations from a number of local and visiting professors including Dr. Kevin Elwood (BC Centre for Disease Control), Dr. David Pi (UBC Division of Pathology and Laboratory Medicine), Dr. Dianne Mosher (Dalhousie University, Halifax), Dr. Gabrial Panayi (London), Dr. Walter Maksymowych (University of Alberta), and Dr. Sylvia Stockler (UBC Paediatrics and BCCH Biochemical Diseases).

Research

Members of the Division continue to be active in the Arthritis Research Centre. The Arthritis Research Centre includes faculty from the Division of Rheumatology, the Department of Orthopedics, the Department of Health Care & Epidemiology, the Department of Pharmaceutical Sciences and the School of Rehabilitation Sciences, as well as from the Centre for Health Evaluation and Outcome Studies at St. Paul’s Hospital, and the Centre for Clinical Epidemiology and Evaluation at Vancouver Acute.

Current research is funded by the Canadian Arthritis Network (a Networks of Centres of Excellence), The Arthritis Society of Canada, the Hecht Foundation, the Lupus Research Institute (US), The Kirkwood Foundation (US) and the Canadian Institutes of Health Research. Faculty members hold scholarships from The Molson Foundation, the Michael Smith Foundation for Health Research, the Arthritis Society of Canada, and the Canadian Institutes of Health Research.

Drs. Kenneth Blocka, Andrew Chalmers, Jan Dutz, John Kelsall, Alice Klinkhoff and Kam Shojania are leading clinical trials at the Arthritis Research Centre. The group’s research focuses primarily on the study of new biological agents.

For the last few years, Dr. Ian Tsang has been pursuing a new research direction. He has been working closely with the Guangzhou Traditional Chinese Medicine University in Guangzhou,

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China, to develop innovative ways to establish clinical evidence for Traditional Chinese Medicine. He has participated in several conferences related to evidence-based medicine in China as a speaker and panel member. He has also published on the subject. His most recent project involves a collaboration between the Faculty of Health Sciences, Simon Fraser University and the Guangzhou Traditional Chinese Medicine University to develop a facility in Vancouver to conduct clinical studies to assess the impact of Traditional Chinese Medicine management on patients with rheumatic conditions.

Clinical Services

The Mary Pack Arthritis Centre (operated by Vancouver Coastal Health; Director, Dr. Alice Klinkhoff) runs extensive drug and disease monitoring clinics, including the Immunosuppressive Clinic (Director, Dr. John Kelsall), the Cyclosporine Clinic (Director, Dr. Andrew Chalmers), the Out-Patient Day Program (Director, Dr. Alice Klinkhoff), the Gold Clinic (Director, Dr. Alice Klinkhoff), the Young Adults with Rheumatic Diseases Clinic (Co-Directors: Dr. David Cabral, Dr. Angela How), and two Combined Clinics in Orthopaedics and Oral Pathology (Director, Dr. Bruce Blasberg). A new Combined Clinic in Dermatology, under the direction of Dr. Jan Dutz, started in June 2007.

The Mary Pack program coordinates the travel of divisional faculty to provide consultation and treatment services in 22 remote locations across the province, including amongst others Trail, Cranbrook, Fort St. John, Prince George, the Queen Charlotte Islands, and Alert Bay. It also provides a variety of educational workshops for patients, as well as physiotherapy, occupational therapy, and access to social workers and vocational counselors.

Ambulatory care clinics offered at St. Paul’s Hospital include those for scleroderma (Director, Dr. James Dunne), low back pain (Director, Dr. Jean Gillies) and a rapid-access program (Director, Dr. John Kelsall). A Lupus Clinic will be starting at St. Paul’s Hospital under the supervision of Dr. Jennifer Reynolds.

A rapid-access clinic for early rheumatoid arthritis patients has been started and is staffed by Drs. David Collins, Alice Klinkhoff, Lucie Wilk, Diane Lacaille and Andrew Chalmers. This clinic will be part of a Canadian network of early rheumatoid arthritis clinics and will share data for research purposes.

The G.F. Strong Rehabilitation Centre’s Arthritis Unit (Director, John Watterson) offers post- operative and rehabilitative services to rheumatology patients along with specialized physiotherapy, occupational therapy and vocational counseling. In-patient services are offered at Vancouver Acute and St. Paul’s Hospital.

Dr. Robert Offer in Penticton has extensive involvement in teaching including rheumatology fellows, residents and medical students. He is involved in many continuing-education events for physicians. Penticton is the major rheumatology resource for the interior with a well-staffed Mary Pack Treatment Centre at Penticton Regional Hospital and a drug monitoring clinic covering more than 500 active rheumatoid arthritis patients. Dr. Offer does outreach traveling consultation clinics and now telemedicine to Creston, as well as research and clinical trials.

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Administration

Dr. Barry Koehler, Clinical Professor Emeritus, was Acting Head from October 2006 until June 2007. Dr. John Esdaile returned from a six-month sabbatical at the Centre of National Research on Disability & Rehabilitation Medicine (CONROD), University of Queensland, in June 2007, and resumed his position as Head of the UBC Division of Rheumatology, the Vancouver Hospital Division of Rheumatology, and the UBC Postgraduate Training Program in Adult Rheumatology.

The Search Committee to select a new Division Head considered several candidates, who were interviewed throughout 2007.

As of January 1, 2008, Dr. Kam Shojania is the Head of UBC Division of Rheumatology. Dr. John Wade remains the Acting Head of the Vancouver Hospital Division of Rheumatology. Dr. Ken Blocka continues as the Head of the St. Paul’s Hospital Division of Rheumatology and also oversees the hospital training program there. Dr. John Watterson oversees the hospital training program at G.F. Strong Hospital. Dr. Alice Klinkhoff is Director of the Mary Pack Arthritis Centre. Dr. John Esdaile continues as the Scientific Director of the Arthritis Research Centre.

Future Directions

In 2008, the Division will continue to pursue excellence in research, teaching and clinical care.

Distinctions and Awards:

Dr. John Esdaile has been elected a Fellow of the Canadian Academy of Health Sciences. Dr. John Esdaile was a visiting professor at the University of Queensland Centre of National Research on Disability and Rehabilitation Medicine (CONROD).

Dr. Ian Tsang was appointed as a Visiting Professor to the Guangzhou University of Traditional Chinese Medicine in China.

Dr. Diane Lacaille was awarded the IMHA Quality of Life Research Award.

Dr. Jean Gilles was awarded the Clinical Faculty Award for Excellence in Teaching in the UBC Faculty of Medicine.

Dr. Jolanda Cibere was awarded a Clinician Scientist Phase 2 Award from the Canadian Institute of Health Research.

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MEDICINE

Members at Large

Faculty Members Clinical Professor Klinke, Dr. Wolf Victoria Clinical Associate Professor Copes, Dr. Raymond BCCDC Clinical Associate Professor Simkus, Dr. Gerald New Westminster Clinical Associate Professor Sparks, Dr. Patricia Sooke Clinical Assistant Professor Aminbakhsh, Dr. Amin New Westminster Clinical Assistant Professor Ashton, Dr. Thomas Penticton Clinical Assistant Professor Blackwell, Dr. Margaret New Westminster Clinical Assistant Professor Buckley, Dr. Alan Victoria Clinical Assistant Professor Chan, Dr. Albert New Westminster Clinical Assistant Professor Collier, Dr. Todd Kamloops Clinical Assistant Professor Cuff, Dr. Darcye SPH Clinical Assistant Professor Forbes, Dr. Anastasia SPH Clinical Assistant Professor Fretz, Dr. Eric Victoria Clinical Assistant Professor Friesen, Dr. Marlyce New Westminster Clinical Assistant Professor Gordon, Dr. Ann New Westminster Clinical Assistant Professor Guzman, Dr. Jaime Vancouver Clinical Assistant Professor Hargrove, Dr. Gaylene Victoria Clinical Assistant Professor Ho, Dr. Kennely New Westminster Clinical Assistant Professor Holland, Dr. Stephen Victoria Clinical Assistant Professor Jones, Dr. Christopher Victoria Clinical Assistant Professor Koziol, Dr. Kathie Victoria Clinical Assistant Professor Kwan, Dr. Susan Burnaby Clinical Assistant Professor Lam, Dr. Sui VA Clinical Assistant Professor MacCarthy, Dr. John New Westminster Clinical Assistant Professor Martinka, Dr. Grzegorz Richmond Clinical Assistant Professor Oyler, Dr. Jeffrey Kamloops Clinical Assistant Professor Pullen, Dr. Brock New Westminster Clinical Assistant Professor Rupka, Dr. Dennis New Westminster Clinical Assistant Professor Saly, Dr. Viera Victoria Clinical Assistant Professor Sanders, Dr. Bruce Victoria Clinical Assistant Professor Schwartz, Dr. Daniel Abbotsford Clinical Assistant Professor Starko, Dr. Robert New Westminster Clinical Assistant Professor Webster, Dr. Sheila New Westminster Clinical Assistant Professor Youakim, Dr. Sami Victoria Clinical Instructor Klinke, Dr. Jennifer New Westminster Clinical Instructor Lee, Dr. Julie New Westminster Clinical Instructor Medvedev, Dr. George New Westminster Clinical Instructor Rosenbaum, Dr. Debbie VA Associate Member Hamm, Dr. Robert Victoria Visiting Associate Professor Takaro, Dr. Timothy Burnaby

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EDUCATION PROGRAMS

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AIDS RESEARCH PROGRAM

Dr. Julio S. G. Montaner Professor & Director

Overview

The AIDS Research Program continues to refine the role of antiretroviral therapy for the treatment of HIV infection. The main areas of research continue to be epidemiology, basic science and clinical science. In the following report we summarize the program's activities and areas of concern for the year 2007.

Epidemiological Research

The epidemiology group has been very productive and continues to benefit from long-term analyses emerging from VIDUS, SEOSI, ACCESS, ARYS, and MAKA cohorts under the leadership of Evan Wood, MD, PhD; Thomas Kerr, PhD; and Mark Tyndall, MD. The Drug Treatment Program, under the leadership of Robert Hogg, PhD, has emerged as a key contributor to our understanding of the dynamics of the HIV epidemic as well as the effect of treatment. Members of our team have received funding from the Canadian Institutes of Health Research for senior scholar research (Mark Tyndall), new investigator award (Thomas Kerr), and masters, doctoral and post-doctoral training. Grant funding was obtained from the Michael Smith Health Research Foundation, Canadian Institutes of Health Research, National Institute of Health in the United States and a number of pharmaceutical companies.

Basic Science

The research laboratory, headed by Richard Harrigan, PhD, and based at the B.C. Centre for Excellence in HIV/AIDS (BC-CfE) has established itself not only as a leading force in Canada, but also as a centre with considerable international influence. The laboratory has provided clinical services to the province of B.C. in the areas of HIV drug resistance testing and pharmacokinetic measurement. The clinical implications and predictors of HIV drug resistance continue to be investigated, both at the BC-CfE and as part of international collaborations. The research laboratory focuses on developing tools with clinical applications that may be employed in the near future. These include techniques for monitoring the side effects and degree of adherence to medications, as well as tracking variations in the HIV and human genomes which are associated with response to HIV therapy, and virus pathogenicity. In addition to providing HIV drug resistance testing as a clinical service to most of Canada and investigator-driven trials,

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the research lab has also received peer-reviewed funding for several studies from the Canadian Institutes of Health Research, Michael Smith Health Research Foundation, and the Ontario HIV Treatment Network. Dr. Richard Harrigan holds the Glen Hillson Professorship in Clinical Virology. Novel testing applications in the laboratory continue to provide testing support for Phase III clinical trials.

Clinical Science

Under the direction of Dr. Julio Montaner and supervised by Dr. Marianne Harris, cutting-edge research continues by members of the clinical science group focusing on the treatment of patients with multidrug-resistant virus, pharmacokinetics of antiretrovirals, optimizing adherence to antiretroviral therapy regimens, recognition and management of drug toxicities, management of viral co-infections, and primary care initiatives.

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The issues surrounding adherence to antiretroviral drug regimens are a topic of active study by the Psychology Team. This part-time team (Dr. Victoria Alfonso, Rand Thomson, and Adrienne Toulson) is presently involved in three projects: reviewing the data collection of the ARMS (Antiretroviral Readiness and Motivation Scale); interviewing and collecting data for a retrospective lipoatrophy study that is gathering information on the psychological and adherence impact of cosmetic interventions for facial lipoatrophy; and finishing the data collection for the HIV/HCV co-infection project. As well, the Psychology Team forms part of the IDC multidisciplinary team. This team provides adherence support for more than 100 patients and is involved in training of psychology interns.

Current Areas of Active Clinical Research • First-line antiretroviral therapy • Salvage therapy for patients with previous treatment failure and multiple drug- resistant HIV • Strategies for optimizing the use of investigational and newly available antiretroviral agents

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International Health

We are currently working in close collaboration with several countries to continue developing resources, training, services and research. These countries include Argentina, Mexico, Africa (Kenya, Uganda, Malawi) and China. There is active collaboration with Médecins Sans Frontières and the World Health Organization to develop antiretroviral guidelines for injection drug users in Eastern European countries and South East Asia, as well as their HIV Drug Resistance Network. We are also involved in a number of international cohort collaborations including the NA-ACCORD and ART Cohort Collaboration.

Integrated Primary and Specialty Care

The John Ruedy Immunodeficiency Clinic (IDC), under the direction of Drs. Julio Montaner and Rolando Barrios, provides primary and specialty care to HIV-infected patients. The clinical team includes individuals with expertise in all areas of HIV care with specific emphasis on primary care, infectious diseases, lipid disorders, anal dysplasia, neurology, dermatology, psychiatry, addiction medicine, internal medicine, counseling and psychology, nephrology, and clinical trial operations. The clinic operates 5 days a week with after-hours on call coverage. A comprehensive team of family physicians, nurses, social workers, nutritionist, pharmacist, and a substance use counselor is available to all patients. A large database has been generated with information on primary care initiatives, allowing a comprehensive assessment of the patient’s health status as well as immunizations, co-morbidities, medications, substance use, and other factors of interest.

The IDC serves the purpose of assisting the rapidly growing HIV population with very complex medical issues. The IDC philosophy is to provide a comprehensive and interdisciplinary approach to HIV positive patient care, which include the following services:

Primary Care Clinic, Side Effects Clinic, AIDS Clinic, Addiction Services, Hepatitis C Clinic, STD Clinic, Specialists Clinic, TDM Clinic, Other Services (pharmacist, nutritionist, social workers, addictions counseling, community support groups, nurse).

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Inpatient HIV/AIDS Care

The inpatient HIV Ward, under the direction of Dr. Peter Phillips, was opened in February 1997 and was expanded from 17 to 20 beds in March 2006. During that nine-year period, there have been approximately 400 admissions to the Ward annually. Approximately 70% of the patients admitted to the Ward are active or previous injection drug users. There are medical diagnoses accounting for hospitalizations including HIV-related opportunistic infections, malignancies, injection drug use-related infections (e.g. cellulitis, endocarditis, osteomyelitis), complications of chronic liver disease (e.g. hepatitis B and C) and adverse effects related to antiretroviral therapy. The Ward provides a multidisciplinary service and has linkages with various other care facilities and support groups in the community. Various policies and procedures have been developed which are specific for HIV/AIDS care. The Ward has attracted trainees from across the country at all levels of undergraduate and postgraduate training.

Undergraduate, Graduate, Post-graduate Education

The following Teaching Rounds are available for all levels:

• Complex Care Patient Rounds (previously known as the IDC Multidisciplinary Rounds). • 10C Rounds-daily bedside teaching to rotating medical students & residents, and residents in the Infectious Diseases and Medical Microbiology training programs on the AIDS Ward (10C), as well as the outpatient clinics. • AIDS Care Rounds-targeted to audiences including AIDS Care Group physicians, nurses (10C and community), IDC physicians, nurses, pharmacist, social workers etc. • Infectious Diseases Intracity Rounds-Weekly city-wide teaching rounds available to medical students, medical residents, and residents in the Infectious Diseases and Medical Microbiology training programs. • Academic Half Day Rounds-available weekly to fellows within the Infectious Diseases and Medical Microbiology training programs. • WiP (Work in Progress) Research Rounds-Forefront. • Web-based HIV teaching-offered via the BC-CfE website where selected rounds and events are posted. • Noon Hour Subspecialty Rounds-available to core internal medicine residents at St. Paul’s Hospital and at Vancouver Hospital & Health Sciences Centre. • Department of Medicine Grand Rounds. • ABC Educational Program-a basic HIV/AIDS educational program for health care professionals and the community that travels across the province. • HIV/AIDS Updates-these one-day programs are conducted twice a year by the BC-CfE. • UBC Co-op and TRID Studentships.

The Preceptorship Program at IDC, coordinated by Dr. Silvia Guillemi, is available at the Post- graduate level:

This is a program for family doctors offered within the IDC at St. Paul’s Hospital. The main objective is to enhance the skills in HIV/AIDS of family physicians. This program consists of an approximate 3-month rotation where physicians are exposed to an interdisciplinary approach to

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the management of HIV/AIDS, as well as participating in primary and specialized care of patients. The rotation involves 50% in primary care at IDC and 50% in academic and research activities.

Students/Residents/Postdoctoral Research Fellows:

Student Name Program Type Dates Supervisor(s) Ainsworth, Liz Research Student- 2007 T. Kerr Epidemiology Barrios, Andrea Student Research Jun–Aug 2007 R. Hogg, J. Montaner Assistant Blades, Ryan Undergrad 2006-07 E, Wood, T. Kerr (biology) Burgess Susan Preceptorship Jan-Mar 2007 J. Montaner (Vancouver) Burkout, Suze MD/PhD- 2005-present M. Tyndall, S. Anderson Interdisciplinary Studies Cohen, Emma Teaching Mar 2007 R. Hogg Assistant-Masters Level (SFU) DeBeck, Kora MSc Public Policy 2006-2007 J. Montaner, T. Kerr, E. Wood

PhD Drug Policy 2007-present Dell, Evelyn Teaching Mar 2007 R. Hogg Assistant-Masters Level (SFU) Dhalla, Shayesta PhD, HIV/vaccines Sept 2005-Nov R. Hogg (Committee (UBC) 2007 member) Fairbairn, Nadia Medical Student 2007 T. Kerr, E. Wood Fielden, Sarah Student Researcher 2005-present R. Hogg Fink, Valeria Preceptorship Jan-Feb 2007 J. Montaner (Argentina) Gill, Vikram MSc 2005-2007 R. Harrigan, M. Tyndall, T. Lampinen Grebaly, Jason PhD-Pharmacology 2003-2007 B. Conway, M. Tyndall, M. Krajden Harrison, Rebecca Student Research May-Aug 2007 R. Hogg, J. Montaner Assistant Hayden, Anna Student Research Jun-Dec 2007 J. Montaner Assistant Hirakata, Pam Psychology Intern 2006-2007 V. Alfonso (UBC)

Hoda, Zia Medical Student 2006-07 Wood, Kerr

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Iniguez, Esmeralda P. Geo, Sept 2005- R. Hogg (Committee HIV/Mexico/model present member) ing (UCSD) Ireland, Laurie Preceptorship Jun 2007 J. Montaner (UBC) Jahnke, Natalie Postdoctoral Sept 2006- J. Montaner Research Fellow- present Health Professional Johnston, Karissa PhD candidate, Sept 2005- A Levy (supervisor), R. HIV & Health present Hogg (Committee member) Economics (UBC) Kaida, Angela PhD candidate, Sept 2005- R. Hogg HIV/fertility/ART/ present S. Africa (UBC) Lazar, Michelle Student Research May-Aug 2007 R. Hogg, J. Montaner Assistant Lima, Viviane PhD 2006-present J. Montaner, R. Hogg Lin, Ada Preceptorship Apr-Jun 2007 J. Montaner (Hong Kong) Lloyd-Smith, Elisa PhD-Epimiology, Sept 2005- R. Hogg, E. Wood, Sheps, T. HIV/IDUs, SIS present Kerr, M. Tyndall (UBC) Low, Andrew MSc 2005-2007 R. Harrigan, J. Montaner, B. Cherkasov Maas, Benjamin Research Assistant 2005-2006 T. Kerr, J. Montaner Marshall, Brandon MSc Epidemiology 2006-present T. Kerr, J. Shoveller McCarthy, Sheila Graduate Student- 2003-present D. Patrick, E. Wood, A. Jolly Epidemiology McKnight, Ian Medical Student 2006-2007 E. Wood, T. Kerr McLaren, Meaghan Preceptorship Apr-Jun 2007 J. Montaner (Ottawa) McLean, Mark Preceptorship Sept-Dec 2007 J. Montaner (Vancouver) Mehrabad, Azar MSc, Sept 2005-Sept R. Hogg (Committee HIV/IDU/Aborigin 2007 member) al (UBC) Miller, Cari Postdoctoral 2006-2007 S. Strathdee, T. Kerr, E. Wood Fellow Milloy, M-J MSc Epidemiology 2006-present T. Kerr, E. Mathias Mtambo, Andy Teaching Mar 2007 R. Hogg Assistant-Masters Level (SFU) Nagberi, Augustina Teaching Feb 2007 R. Hogg Assistant-Masters Level (SFU) Ng, Francisco Postdoctoral 2005-Jun 2007 J. Montaner

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Research Fellow- Health Professional Ochoa, Paula Postdoctoral Jun 2007- J. Montaner Research Fellow- present Health Professional Ogembo, Brenda Teaching Feb-Mar 2007 R. Hogg Assistant-Masters Level (SFU) Rachlis, Beth MSc- Sept 2005-Oct R. Hogg, J. Montaner, T. Epidemiology, 2007 Kerr, E. Wood HIV/migration/ID U (UBC) Reilly, Greg Teaching Feb 2007 R. Hogg Assistant-Masters Level (SFU) Remple, Valencia MD/PhD-Health 2003-2007 D. Patrick, M. Tyndall, A. Care & Jolly Epidemiology Reyes-Smith, Larina Preceptorship Nov-Dec 2007 J. Montaner (UBC) Richardson, Lindsey MSc Sociology 2007-2007 Kerr, Wood Rocha, Clara Postdoctoral Dec 2005-Jun J. Montaner Research Fellow- 2007 Health Professional Rusch, Melanie PhD-Health Care 2007 M. Tyndall, J. Shovellar, D. & Epidemiology Patrick Sadr, Aida Preceptorship Sept-Nov 2007 J. Montaner (UBC) Shannon, Kate PhD Epidemiology 2004-present M. Tyndall, T. Kerr Small, Will PhD Epidemiology 2005-present J. Shoveller, T. Kerr, E. Wood Stoltz, Jo-Anne Postdoctoral 2006-present E. Wood, T. Kerr, R. Hogg Fellow Taylor, Darlene MSc-Health Care 2004-present M. Tyndall, D. Patrick & Epidemiology Thomson, Rand Psychology Intern 2007 V. Alfonso (UBC) Wali, Ghassan Clinical Fellow Aug 2006-Jul J. Montaner, P. Phillips (Saudi Arabia) 2007 Watson, Emma Student Research Jun 2006-Dec J. Montaner, R. Harrigan Assistant 2007 Werb, Daniel Research Assistant Jun 2006-Nov T. Kerr, J. Montaner 2007 Wood, Alan Nursing 2007-present T. Kerr, Rodney Wood, Evan Preceptorship Mar-Apr 2007 J. Montaner (Calgary)

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Wynne, Elaine Preceptorship May 2007 J. Montaner (Vancouver) Al Barrak, Jasem Residency- 2007 J. Montaner Al Fagih, Rashed Infectious Diseases Badawi, Maha and HIV/AIDS Ko, Hinhin Nguyen, Van Paulus, Stephane Peters, Laurenna Rizkallah, Jacques Rodrigo, Judith Stephanovic, Aleksandra Waechter, Jason

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Grants Granting Agency Subject $ (C)* $ (NC)** Year(s) PI Co-Investigator(s) Vancouver Costal Health Scientific Evaluation of the Supervised Injection Site T. Kerr J. Montaner; M. Tyndall; E. $450,000 2003-2007 Authority (SEOSI) Wood UBC Training Program for Translational Research in R Brunham; R Hancock; M Canadian Institutes of Health $300,000 2003-2009 M Tyndall Infectious Diseases (TRID) Schechter Establishing the relationship between resistance phenoType or inhibitory quotient and clinical outcomes CS Alexander; R Canadian Institutes of Health $8,600 2004-2007 RS Hogg; J Montaner for patients harbouring drug resistant HIV in British Harrigan Columbia A randomized, placebo controlled trial of citalopram for the prevention of depression and its consequences in Canadian Institutes of Health $34,952 2004-2007 M Klein V. Montessori HIV-Hepatitis C co-infected individuals initiating pegylated interferon/ribavirin therapy (CTN 194) T Kerr; RS Hogg; JS Montaner; Investigating barriers to HIV/AIDS care among CANFAR $60,000 2005-2007 E Wood J Stoltz; S Strathdee; A Palepu; injection drug users M Tyndall; PR Harrigan T Kerr; R Hogg; JS Montaner; J HAART use, methamphetamine exposure and HIV $100,017 National Institutes of Health 2005-2007 E Wood Stoltz; S Strathdee; A Palepu; M resistance among injection drug users USD Tyndall; PR Harrigan A phase 3, randomized, double-blind, multinational trial of intravenous Telavancin versus vancomycin for treatment of complicated gram-positive skin and skin Theravance, Inc. $10,000 2005-2007 P. Phillips (multicenter) structure infections with a focus on patients with infections due to methicillin-resistant staphylococcus aureus. Canadian Institutes of Health Evaluating the natural history of injection drug use $80,000 2005-2008 E. Wood; T. Kerr M. Tyndall; J. Montaner MAKA initiative: HIV treatment and care among T. Kerr; E. Wood; A. Palepu; C. Canadian Institutes of Health $98,000 2005-2008 M. Tyndall women survival sex workers Patton $500,000 P Spittal; MT Schechter; RS National Institute of Health Evaluating the natural history of injection drug use 2005-2008 E Wood; T Kerr Hogg; JSG Montaner; PR 2RO1-DA011591-04A1 (VIDUS) Harrigan; D Patrick P Spittal; RS Hogg; T Kerr; J The Vancouver injection drug users study: A E Wood Montaner; PR Harrigan; D Canadian Institutes of Health programme of study of HIV and hepatitis C and other $158,355 2005-2009 Patrick; MT Schechter; M harms related to injection drug use Tyndall A feasibility study of chemotherapy and mandatory M Loutfy; E Phillips; K Canadian Institutes of Health combination antiretroviral therapy for management of $44,235 2005-2009 M. Cheung Pritchard AIDS-related lymphoma

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H Cote; V J Montaner; R Barrios; M Canadian Institutes of Health Mitochondrial toxicity in HIV/HCV coinfection therapy $75,000 2005-2010 Montessori Harris; D Walker Further application of cutaneous, genetic and M Harris; R Harrigan; R Kaul; S Canadian Dermatology R Crawford; EJ immunologic testing for the management of abacavir $20,000 2006-2007 Knowles; S Mallal; J Montaner; Foundation Phillips; NH Shear hypersensitivity syndrome A McLeod R Crawford; N Shear; M Harris; The immunologic, genetic and metabolic basis for R Harrigan; R Kaul; S Knowles; CANFAR abacavir hypersensitivity reaction: further application $25,000 2006-2007 EJ Phillips S Mallal; J Montaner; A of genetic, immunologic and cutaneous testing McLeod; A Rachlis Vancouver Coastal Health Vancouver Urgent Response Centre (URT) Evaluation $90,000 2006-2007 T Kerr; E Wood Michael Smith Foundation An investigation of injection drug use and HIV for Health Research $37,500 2006-2008 T Kerr infection among drug using youth Establishment Grant D Patrick; V Canadian Institutes of Health HIV/AIDS prevention with indoor sex workers $88,000 2006-2009 M Tyndall; A Jolly Remple V Bright; K Gibson; F Ibanez- Enhancing uptake and sustainability of HIV care and Carrasco; T Kerr; T Orchard; A Canadian Institutes of Health antiretroviral therapy among survival sex workers $125,074 2006-2009 M Tyndall Palepu; C Patton; K Shannon; E (MAKA) Wood Development and testing in a phase I/II clinical trial of R Sekaly; J M Boulassel; E Elhaddad; J Canadian Institutes of Health a therapeutic HIV vaccine using dendritic cells $192,150 2006-2009 Montaner; J Routy Singer transfected with autologous HIV RNA Pathological and functional correlates of antiretroviral Canadian Institutes of Health R Joy; J Montaner; V drug exposure in patients co-infected with $143,550 2006-2009 E Phillips; H Cote (CIHR)-Operating Grant Montessori HIV/hepatitis C J Montaner; J Stoltz; MW Canadian Institutes of Health Evaluating a peer-driven safer injecting education $92,767 2006-2009 T Kerr Tyndall; E Wood; N Fairbairn; Operating Grant program D Tobin; M Oleson; W Small Canadian Institutes of Health Exploring the natural history of injection drug use: A E Wood; C Duff; W Small; J $29,233 2006-2009 T Kerr Operating Grant qualitative study of social and environmental influences Montaner; J Stoltz; J Shoveller Michael Smith Foundation Scholar Award $45,000 2006-2009 T Kerr for Health Research Canadian Institutes of Health Vancouver multi-disciplinary collaboration of injection MW Tyndall; SA Strathdee; DC $169,676 2006-2010 T Kerr; E Wood Operating Grant drug use researchers Marsh; JM Stoltz; A Palepu M Tyndall; T Kerr; J Montaner; Canadian Institutes of Health Research in addictions team grant $169,000 2006-2011 E Wood D Marsh Canadian Institutes of Health New Investigator Award $50,000 2006-2011 T Kerr Investigating and addressing barriers to human T Kerr; R Harrigan; R Hogg; J Canadian Institutes of Health immunodeficiency virus (HIV) and hepatitis C virus $157,952 2006-2011 E Wood Montaner; A Palepu; J Stoltz; M Operating Grant (HCV) care among injection drug users Tyndall UBC Department of Medicine Page 167 Annual Report 2007

Michael Smith Foundation Senior Scholar Award $100,000 2006-2011 M Tyndall for Health Research Abbott Laboratories Grant-in-aid (A06-320) $52,670 2007 J Montaner Tibotec Pharmaceuticals Grant-in-aid $100,000 2007 J Montaner Early access of TMC125 in combination with other antiretrovirals in treatment-experienced HIV-1 infected Tibotec Pharmacueticals $125,000 2007 J Montaner subjects with limited treatment options (TMC125- C214) Investigating the impact of HAART on sexual and CANFAR reproductive behaviours and fertility among HIV- $25,000 2007-2008 R Hogg positive women in South Africa CIHR Defining evidence-based strategies for HIV treatment in Synthesis Grant: Knowledge $66,799 2007-2008 T Kerr; E Wood injection drug users Translation A multicenter, double-blind, randomized, placebo- controlled study assessing the efficacy and safety of a TheraTechnologies Inc. 2mg dose of TH9507, a growth hormone releasing $8,486 2007-2008 J Montaner factor analog, in HIV subjects with excess abdominal fat accumulation (TH9507-CTR-1011) The impact of antiretroviral care on the health and well T Kerr; J Montaner Canadian Institutes of Health $158,809 2007-2009 R Hogg being of person infected with HIV/AIDS E Wood T Kerr; JS Montaner; A Palepu; Impacts of universal access to HIV/AIDS care among National Institutes of Health $433,866 2007-2012 E Wood PR Harrigan; D Bangsberg; SA HIV+ Injection Drug Users Strathdee; J Stoltz

Competitive $4,128,535 Non-competitive 296,156 FINAL TOTAL $4,424,691

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Awards & Distinctions

Winner Name Winner Title(s) Full Name of Award Full Name of Awarding Body Description* MD; Professor of Medicine, Chair UBC Killam Research Prizes are awarded annually in AIDS Research and Head of to top campus researchers. Up to ten prizes in the Division of AIDS, UBC; Director UBC Killam Prize for Senior amount of $5,000 each are awarded to fulltime Julio S. G. Montaner UBC Killam Prize of the BC Centre for Excellence Sciences Category faculty members in recognition of outstanding in HIV/AIDS; President-Elect, research and scholarly contributions of International AIDS Society international significance. This honour recognizes a scientist in the Providence Health Care organization who demonstrates the mission and Julio S. G. Montaner Research & Mission Award Research Institute values of Providence Health Care while conducting outstanding research. Distinguished Achievement Julio S. G. Montaner UBC Faculty of Medicine Special meritorious recognition Award for Overall Excellence Science & Technology These awards honour the pioneers and visionaries Champion of the Year Award who are advancing British Columbia as a world- Julio S. G. Montaner (leadership in HIV/AIDS clinical BC Innovation Council class centre for innovation. BC Innovation Council work and research) award winners are widely renowned as leaders in research, technology and innovation. Each year the VMA executive recognize and Vancouver Medical Julio S. G. Montaner Osler Lecture choose a prominent physician to give the Osler Association Lecture. PHD; MSFHR Scholar; Research The award is given to a UBC faculty member who Scientist, BC Centre for Presidents Award for Public has most demonstrated outstanding service to the Thomas Kerr Excellence in HIV/AIDS; University of British Columbia Education Through Media university and the community by sharing research Assistant Professor, Dept. Of expertise via the news media. Medicine, UBC This award honours and supports teams or organizations that make an outstanding National Award for Knowledge Canadian Institutes for Health Thomas Kerr contribution to the health of Canadians or to the Translation Research health system through exemplary knowledge translation. MD, PhD; Researcher, BC Centre This is awarded annually to individuals who have for Excellence in HIV/AIDS; Canadian Medical Association Evan Wood Canadian Medical Association made a leadership contribution to national or Clinical Assistant Professor, Award for Young Leaders international public health or medical issues. Dept. of Medicine, UBC

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Edward Mills Research Scientist, BC Centre for The top 20 most important The Lancet Research paper (Mills EJ, Nachega JB, Buchan I, Excellence in HIV/AIDS medical papers of 2006 Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, (awarded in 2007) Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta- analysis. JAMA. 2006 Aug 9;296(6): 679-90.) named one of the top 20 most important medical papers of 2006 by The Lancet. Kate Shannon Project Coordinator, New Investigator Award, Canadian Association for A New Investigator Award is given each year at PhD Candidate at the BC Centre Epidemiology & Public Health HIV/AIDS Research the CAHR conference to the best candidate in each for Excellence in HIV/AIDS Track, top-scoring presentation track, based on excellence in both research and and research, Canadian presentation. Applicants must have received their HIV/AIDS Research most recent degree no more than five years Conference, May 2007 previously. Kate Shannon International AIDS Society International AIDS Society 200 scholarships were awarded from a pool of Scholarship, 4th International over 3,000 applications, with only 20% of those HIV Pathogenesis and Treatment going to researchers from North America or Conference, Sydney, Australia, Europe, to present their work at the conference. July 2007 Kate Shannon Canadian HIV/AIDS Research Canadian Association for Two academic scholarships are awarded to Conference Scholarship, top- HIV/AIDS Research students in each research track to present their scoring abstract, Social Sciences work at the conference. Track, Toronto, Canada, May 2007 Kate Shannon CIHR Summer Institute Canadian Institutes of Health Selected through peer-review as one of top 30 Scholarship, "Population and Research PhD/ post-doctoral trainees across Canada to Public Health participate, Banff, Alberta. Intervention Research: Creating New Ways Forward", selected through peer-review as one of top 30 PhD/ post doctoral trainees across Canada to participate, Banff, Alberta, June 2007 Edward Mills Research Scientist, BC Centre for The top 20 most important The Lancet Research paper (Mills EJ, Nachega JB, Buchan I, Excellence in HIV/AIDS medical papers of 2006 Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, (awarded in 2007) Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR. Adherence to antiretroviral therapy

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in sub-Saharan Africa and North America: a meta- analysis. JAMA. 2006 Aug 9;296(6): 679-90.) named one of the top 20 most important medical papers of 2006 by The Lancet. Kate Shannon Project Coordinator, New Investigator Award, Canadian Association for A New Investigator Award is given each year at PhD Candidate at the BC Centre Epidemiology & Public Health HIV/AIDS Research the CAHR conference to the best candidate in each for Excellence in HIV/AIDS Track, top-scoring presentation track, based on excellence in both research and and research, Canadian presentation. Applicants must have received their HIV/AIDS Research most recent degree no more than five years Conference, May 2007 previously. Kate Shannon International AIDS Society International AIDS Society 200 scholarships were awarded from a pool of Scholarship, 4th International over 3,000 applications, with only 20% of those HIV Pathogenesis and Treatment going to researchers from North America or Conference, Sydney, Australia, Europe, to present their work at the conference. July 2007 Kate Shannon Canadian HIV/AIDS Research Canadian Association for Two academic scholarships are awarded to Conference Scholarship, top- HIV/AIDS Research students in each research track to present their scoring abstract, Social Sciences work at the conference. Track, Toronto, Canada, May 2007 Kate Shannon CIHR Summer Institute Canadian Institutes of Health Selected through peer-review as one of top 30 Scholarship, "Population and Research PhD/ post-doctoral trainees across Canada to Public Health participate, Banff, Alberta. Intervention Research: Creating New Ways Forward", selected through peer-review as one of top 30 PhD/ post doctoral trainees across Canada to participate, Banff, Alberta, June 2007 Kate Shannon BC Child & Youth Institute BC Child & Youth Health Ten scholarships were awarded to BC child and Scholarship, International Health Research Network youth health researchers to present their work at Promotion & the conference. Education Conference, Vancouver, Canada, June 2007 Will Small Project Coordinator, New Investigator Award, Social Canadian Association for A New Investigator Award is given each year at PhD Candidate, at the BC Centre Sciences Track, top-scoring HIV/AIDS Research the CAHR conference to the best candidate in each for Excellence in HIV/AIDS presentation and research, track, based on excellence in both research and

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Canadian HIV/AIDS Research presentation. Applicants must have received their Conference, May 2007 most recent degree no more than five years previously. Will Small Canadian HIV/AIDS Research Canadian Association for Two academic scholarships are awarded to Conference Scholarship, Social HIV/AIDS Research students in each research track to present their Sciences Track, Toronto, work at the conference.. Canada, May 2007 Vikram Gill Graduate Student in the Research Young Investigator Award to The Scientific Program This is a competitive scholarship for post-doctoral Laboratories at the BC Centre for present research at the 14th Committee for the Conference fellows and graduate students to present research Excellence in HIV/AIDS Conference on Retroviruses and on Retroviruses and at CROI and is awarded based on the quality of the Opportunistic Infections (CROI) Opportunistic Infections submitted abstracts and a recommendation from a in Los Angeles, Feb. 25-28, mentor. CROI is one of the pre-eminent annual 2007. scientific conferences in the field of HIV/AIDS research. Andrew Low Graduate Student in the Research Young Investigator Award to The Scientific Program This is a competitive scholarship for post-doctoral Laboratories at the BC Centre for present research at the 14th Committee for the Conference fellows and graduate students to present research Excellence in HIV/AIDS Conference on Retroviruses and on Retroviruses and at CROI and is awarded based on the quality of the Opportunistic Infections (CROI) Opportunistic Infections submitted abstracts and a recommendation from a in Los Angeles, Feb. 25-28, mentor. CROI is one of the pre-eminent annual 2007. scientific conferences in the field of HIV/AIDS research. Brandon Marshall Research Assistant, Graduate Michael Smith Foundation for Michael Smith Foundation for MSFHR Research Trainee Program Awards Student at the BC Centre for Health Research Junior Trainee Health Research support highly qualified Master's trainees to Excellence in HIV/AIDS Award prepare for careers as independent health researchers. Viviane Dias Lima Senior Biostatistician, BC Centre Fellowship Award Canadian Institutes of Health CIHR fellowships provide support for highly for Excellence in HIV/AIDS Research qualified candidates at the post-PhD or post-health professional degree stages to add to their experience by engaging in health research either in Canada or abroad. Elisa Lloyd-Smith Research Assistant, PhD International AIDS Society International AIDS Society 200 scholarships were awarded from a pool of Candidate at the BC Centre for Scholarship, 4th International over 3,000 applications, with only 20% of those Excellence in HIV/AIDS HIV Pathogenesis and Treatment going to researchers from North America or Conference, Sydney, Australia, Europe, to present their work at the conference. July 2007 Elisa Lloyd-Smith BC Child & Youth Institute BC Child & Youth Health Ten scholarships were awarded to BC child and Scholarship, International Health Research Network youth health researchers, based on the quality of Promotion & the submitted abstracts, to present their work at the Education Conference, conference.

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Vancouver, Canada, June 2007 Elisa Lloyd-Smith Research Assistant, PhD Student Scholarship, Canadian Public Health Agency of Scholarships were awarded to health researchers, Candidate at the BC Centre for Public Health Association Canada based on the quality of the submitted abstracts, to Excellence in HIV/AIDS Conference present their work at the conference. Beth Rachlis Research Assistant, Graduate Travel Scholarship, 2007 Annual Western Regional Training Scholarships were awarded to health researchers, Student at the BC Centre for CAHSPR Conference, Centre for Health Services based on the quality of the submitted abstracts, to Excellence in HIV/AIDS (Canadian Association for Research (UBC) present their work at the conference. Health Services and Policy Research), June 12-14, Toronto. Kora DeBeck Research Assistant, Graduate CIHR’s Institute of Infection and Canadian Institutes of Health Doctoral Research Awards are intended to provide Student at the BC Centre for Immunity HIV/AIDS Research Research special recognition and support to students who Excellence in HIV/AIDS Initiative Doctoral Research are pursuing a PhD degree in a health-related field Award –Health in Canada or abroad. Services/Population Health Stream

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CLINICAL INVESTIGATOR PROGRAM

Dr. Anita Palepu Associate Professor & Director

The Clinical Investigator Program (CIP) program is an integral component of the Department of Medicine. Its main goals are to integrate promising medical students, residents and fellows into an academic environment that sustains and nurtures academic interests. Dr. Palepu, in her role as director of this program, has been advocating for young investigator participation and interest in research activities. The CIP program is a resource, which permits divisions within the DOM to leverage funding opportunities in order to support the academic endeavors of those divisions.

The Faculty Clinical Investigator Program is a 2-year program, which has the potential to fund at least 4 individuals each year. Current CIP young investigators enrolled in the DOM CIP program from 2007 include: Dr Jag Gill (2nd year) Nephrology, Dr Catherine Weber, Nephrology (1st year), Dr Carolyn Taylor, Cardiology (1st year).

Accomplishments of those individuals are listed in the appendix below.

Given the importance of the CIP program to the growth and sustainability of research programs, the director has been more formally integrated into key activities of the DOM. This has included presentations to the DOM business meetings at both PHC and VGH sites, and ongoing interaction with Division Heads at the UBC DOM Division Heads meeting held monthly and at the quarterly Subspecialty Program Directors meetings. She has also presented to the core internal medicine residents early in their academic year to increase awareness of opportunities to pursue a research career through the CIP.

The CIP director also provides advice and support to CIP trainees as they negotiate their first faculty position and provide referee letters for external funding.

One new initiative that is supported by the DOM and the core Internal Medicine training program is the opportunity for up to two core Internal Medicine residents to pursue research training during their residency. This initiative is also supported by the Faculty of Medicine CIP and the director participates in the Faculty CIP committee.

UBC Department of Medicine Page 175 Annual Report 2007

CIP goals for 2007-8 1. Educate the core Internal Medicine resident trainees about the Clinical Investigator Program and help interested trainees decide on the appropriate time in their to enter the program. *Strategies include presenting at academic half day about the CIP and meeting individually with interested resident trainees

2. Increase awareness of the CIP among the Internal Medicine subspecialty programs and their trainees. *Discussing the program at the Subspecialty Program Directors meeting, updating the Departmental Executive committee and liasing with Dr Sian Spacey, the Faculty CIP Director.

APPENDIX

Dr. Jag Gill (2nd year) Division: Nephrology Supervisors: Dr. John Gill, Dr. Michael Cecka, Dr. Gabriel Danovitch

Abstracts

Gill J, Shah T, Takemoto S, Bunnapradist S. Kidney Transplantation in the Elderly Recipient using Deceased Donor after Cardiac Death Organs. American Society of Nephrology. San Francisco, CA, USA, November, 2007. Podium Presentation

Gill J, Cho YW, Danovitch GM, Wilkinson A, Lipshutz G, Pham PT, Bunnapradist S. The Use of Pre-Transplant Donor Biopsies and Outcomes of Dual Adult Kidney Transplants. Canadian Society of Nephrology, Halifax, NS, Canada, May 2007. Podium Presentation

Gill J, Bunnapradist S, Pham PT, Danovitch GM, Wilkinson A, Chavalitdhamrong D, Cho YW. Impact of Pulsatile Perfusion of Transplants from Deceased Donors After Cardiac Death: A OPTN/UNOS Analysis. Canadian Society of Nephrology, Halifax, NS, Canada, May 2007. Poster Presentation

Gill J, Bunnapradist S, Gill J, Danovitch GM, Wilkinson A, Cecka MJ. Older Living Donors: A Better Alternative for Older Patients. American Transplant Congress, San Francisco, CA, USA, May 2007. Podium Presentation

Gill J, Cho YW, Danovitch GM, Wilkinson A, Lipshutz G, Pham PT, Bunnapradist S. Outcomes of Dual Adult Kidney Transplants: An Analysis of the UNOS/OPTN Database. American Transplant Congress, San Francisco, CA, USA, May 2007. Podium Presentation

Publications

Gill J, Cho YW, Danovitch GM, Wilkinson A, Lipshutz G, Pham PT, Gill JS, Shah T, Bunnapradist S. Outcomes of Dual Adult Kidney Transplants in the United States: An Analysis of the OPTN/UNOS Database. Transplantation. 2008:85(1).

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Gill J, Malyuk R, Djurdjev O, Levin A. Use of GFR Equations to Adjust Drug Doses in An Elderly Multiethnic Group: A Cautionary Tale. Nephrology Dialysis Transplantation. 2007 Advance Access published Jun 16, 2007.

Danovitch GM, Gill J, Bunnapradist S. Immunosuppression of the Elderly Kidney Transplant Recipient. Transplantation. 2007 Aug 15; 84(3):285-91.

Gill JS, Gill J, Rose C, Zalunardo N, Landsberg D. The Older Living Kidney Donor: Part of the Solution to the Organ Shortage. Transplantation. 2006 Dec 27; 82(12): 1662-6.

In Submission

Gill J, Bunnapradist S, Gill J, Danovitch GM, Wilkinson A, Cecka MJ. Older Living Donors: A Better Alternative for Older Patients.

Chavalitdhamrong D, Gill J, Cho YW, Bunnapradist S. Patient and Graft Outcomes from Deceased Kidney Donors Aged 70 years and Older: An Analysis of the OPTN/UNOS Database.

Research in Progress

Gill J, Gjertson D, Bunnapradist S, Cecka MF. The Impact of Transplant Center Practice on the Association Between pulsatile perfusion and delayed graft function. Abstract. Submitted for presentation at the American Transplant Congress, 2008. Toronto, ON.

Gill J, Lipshutz G, Gjertson D, Bunnapradist S, Madhira B, Wilkinson A, Cecka MJ, Danovitch GM. Transplant Tourism in the US: A single center experience. Abstract. Submitted for presentation at the American Transplant Congress, 2008. Toronto, ON.

Degree Programs Enrolled

Masters in Public Health, Harvard School of Public Health Completion August 2008

Funding 2007-08

KRESCENT (Kidney Research Scientist Core Education and National Training Program) Fellowship Grant: awarded Kidney Foundation Biomedical Research Fellowship Grant: awarded and declined

Awards Trainee Clinical Award. Annual Conference of the Canadian Society of Transplantation. 2008.

Outstanding Clinical Science Research Award. AMGEN Nephrology Young Investigator Forum, San Diego, CA. 2007.

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Dr Catherine Weber (1st year) Division: Nephrology Supervisor: Dr. Adeera Levin

Abstracts and Presentations

Weber CL. INTERACTEDD: Integrated Studies in Vascular Reactivity and Anemia in Chronic Kidney Disease and Dialysis patients. B.C. Nephrology Days, Oral Presentation. Vancouver, British Columbia. October 2007.

Publications

Weber CL, Frohlich J, Chan-Yan C. Reply-Stability of lipids on peritoneal dialysis in a patient with familial LCAT deficiency. Nephrol Dial Transplant. 2007, in press.

Weber CL, Frohlich J, Chan-Yan C. Stability of lipids on peritoneal dialysis in a patient with familial LCAT deficiency. Nephrol Dial Transplant. 2007 Jul; 22(7):2084-8. Epub 2007 Apr 23.

Weber CL, Bartley D, Al-Thaqafi A, Embil JM. Blastomyces dermatitidis osteomyelitis of the tibia. Am J Orthop. 2007 Jan; 36(1): 29-32.

Research in Progress

INTERACTEDD: INTEgrated Studies in Vascular Reactivity and Anaemia in Chronic Kidney Disease and Dialysis Patients.

This is an observational study examining the relationship between vascular stiffness, hemoglobin concentration and erythropoeiten dose in hemodialysis, peritoneal dialysis and chronic kidney disease patients. We will be using the SyphygmoCor device to measure Augmentation Index and Pulse Wave Velocity (measures of vascular stiffness), and be performing special blood tests (Circulating Microparticles which are markers of endothelial activation/damage) over a six-month period of time.

We plan to compare groups at different concentrations of hemoglobin (100-110g/L, 111-120g/L and 121-130g/L). We hypothesize that those patients with the highest degrees of vascular stiffness will benefit from a ‘lower’ hemoglobin concentration.

INTERACTEDD is a multi-national study (Germany, Australia and Canada). In December 2007, the study received ethics approval at St. Paul’s Hospital. Recruitment is starting in January 2008, and we are hoping to enroll 90 patients at the St. Paul’s Hospital site.

Degree Programs Enrolled

Masters in Clinical Epidemiology University of British Columbia Completion May 2009

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Funding

Submitted applications to KRESCENT (Kidney Research Scientist Education and National Training Program) and Kidney Foundation of Canada for funding 2008 onward, awards to be announced May 2008

Dr. Carolyn Taylor (1st year) Division:Cardiology Supervisors: Dr. Sammy Chan (SPH, Vancouver, BC) Dr. Christine Seidman (Harvard University, Boston, MA) Dr. Udo Hoffmann (Mass General, Boston, MA)

Abstracts

American Heart Association 2007 (Orlando, FL)

Taylor CM, Aymong ED, Hochman JS et al. The presence of ST-segment elevation in lead aVR in cardiogenic shock is a predictor of mortality. Circulation 2007; 116 (2): 526.

Canadian Cardiovascular Congress 2007 (Quebec City, QC)

Taylor CM, Brunner NW, Seidman CE et al. Prevalence of four conventional risk factors in Fijian Indo-Canadians: Young versus old. Canadian Journal of Cardiology 2007; 23 (SC): 304.

Brunner NW, Taylor CM, JA Cairns et al. The effect of migration on coronary artery disease in Fijian South Asians: Does migration matter? Canadian Journal of Cardiology 2007; 23 (SC): 612.

Murphy CJ, Brunner NW, Taylor CM et al. Diffuseness of coronary arteriosclerosis in dyslipidemic diabetics versus non-dyslipidemic diabetics. Canadian Journal of Cardiology 2007; 23 (SC): 509

Publications

Taylor CM, Cheung A, Kaan A et al. Left ventricular assist device – motor wear. Images in Clinical Medicine. Canadian Journal of General Internal Medicine 2007; 2(2): 20-24.

Submitted Publications

Taylor CM, Humphries KH, Pu A et al. A Clinical Prediction Tool to Validate Selection of Coronary Imaging Modality May Help Avoid Unnecessary Coronary Angiography. Submitted: JACC Imaging, December 2007, under review.

Drafted Manuscripts Taylor CM, Aymong ED, Hochman JS et al. The presence of ST-segment elevation in lead aVR in cardiogenic shock is a predictor of mortality. For submission Am Heart J, January 2008.

UBC Department of Medicine Page 179 Annual Report 2007

Research in Progress

The Role of Cardiac CT Angiography in Stable Angina *Massachusetts General Hospital (Dr. Udo Hoffmann)

Extending the Benefits of Cardiac Rehabilitation to Rural British Columbia *St. Paul’s Hospital Healthy Heart Program (Dr. Sammy Chan)

South Asian Premature Coronary Artery Disease Genetics Study * The Department of Genetics, Harvard Medical School (Dr. CE Seidman)

A Clinical Prediction Model to Select Patients who have High Likelihood of Not Requiring Cardiac Revascularization

*The University of British Columbia (RG Carere, K Humphries, A Pu) and The University of Calgary (W Ghali, M Knudtson)

The ECG in Cardiogenic Shock and Prediction of Outcomes *The University of British Columbia (K Ramanathan and ED Aymong) and New York University (JS Hochman)

Degree Programs Enrolled

Masters of Public Health Harvard University Expected matriculation: June 2008

Program description: The full-time, one-year MPH at Harvard University is a demanding, interdisciplinary program emphasizing student-directed learning, problem-solving, and the acquisition of fundamental public health skills (biostatistics, epidemiology, environmental health sciences, health services administration, and social and behavioural sciences). In addition to completing a core curriculum, students pursue their professional objectives through a choice of seven career-oriented concentrations, which offer specialty electives and areas of interest. The concentrations and areas of interest enable students to establish links with one or more of the school's academic departments. MPH students are required to complete a minimum of 42.5 course credits (beginning in the 2007 - 2008 academic year) and must fulfill core requirements in the fundamental public health disciplines. I have selected a concentration in disease prevention and health promotion, with a focus on cardiovascular disease and modifiable risk factors for CV disease including obesity, smoking and lifestyle factors.

Awards Canadian Cardiovascular Society (CCS) Trainee Excellence in Education Award 2007 Dr. Stefan Grzybowski Prize (Best Research Project by a Fellow) 2007 Dr. Max B Walters Cardiology Resident Award 2007 Best Teaching by a Cardiology Fellow 2007

UBC Department of Medicine Page 180 Annual Report 2007

CONTINUING MEDICAL EDUCATION PROGRAM

Dr. G.B. John Mancini Professor & Director

Kathy Standeven Program Organizer

New Initiatives/Developments In our fiscal year 2007, the department successfully planned and delivered three Continuing Medical Education events:

The 9th Annual Respiratory Update Conference was held March 29-30, 2007 at the Hyatt Regency Hotel in Vancouver. The two day event was well-attended and received by a mix of 125 physicians, therapists and other allied health professionals.

Our “10th Annual Medicine in the 21st Century” Conference was held June 14 – 16, 2007 at the Sheraton Vancouver Wall Centre Hotel. A distinguished roster, comprised of twenty three UBC Faculty members, delivered a series of didactic presentations and small case based workshop sessions to over 100 physicians and allied health professionals from across Canada and the United States. Once again this event was well-attended and the quality, as in past years, was rated highly.

In August, we held our bi-annual Vascular Biology Working Group meeting comprised of 18 nationally renowned experts to discuss Underlying Mechanisms for Therapies on the Horizon. Manuscripts presented at the meeting have been submitted to the Canadian Journal of Cardiology for a supplement issue to be published in 2008.

The department continues to offer the CME conferences with the goal of generating funding for the Department of Medicine Academic Enhancement Fund. This fund helps support junior faculty who need protected time and other resources to develop their academic credentials in teaching and research.

We would like to thank our many Faculty Members who have contributed their time by participating in our CME events. Without their continued support we would be unable to continue to offer high quality, well-attended CME events.

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GRADUATE STUDIES PROGRAM IN EXPERIMENTAL MEDICINE

Dr. Vincent Duronio Professor & Director

Divisional Overview

Experimental Medicine is the UBC graduate studies program, within the Department of Medicine, which was developed to train individuals seeking a career in biomedical research. Students are enrolled in both MSc and PhD degree programs. Subspecialties within the Experimental Medicine Program include Cancer Biology, Cardiology, Gastroenterology, Haematology/Oncology, Immunology, Infectious Diseases, Molecular Biology, Nephrology, Neurology, Pediatrics, Physiotherapy and Respiratory Medicine. A substantial number of students in the program are under the supervision of faculty members outside of the department. In 2007, 32 new students were admitted to the program. At the end of 2007, there were 140 students registered in the program, 57 for MSc degrees and 83 for PhD degrees.

During 2007, a total of twenty students graduated, eight at the May 2007 Convocation and twelve at the November 2007 Convocation. Student names and thesis titles are listed below (research supervisor in parenthesis):

PhD Graduates

1) Haydeh Behzad, Diverse Roles of the Bcl-2 Family Proteins in Hemopoietic Cell Regulation, (Dr. Vincent Duronio)

2) Natasha Crellin, Molecular Phenotype of Human CD4+CD25+ T regulatory cells, (Dr. Megan Levings)

3) Lynsey Huxham, The tumour microenvironment: mapping the microregional effcts of drugs, (Dr. Andrew Minchinton)

4) Alastair Kyle, Evaluating of the extravascular penetration and diffusion of anti-cancer drugs using a novel application of the multilayered cell culture model, (Dr. Andrew Minchinton)

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5) Haowei Li, Characterization of regulatory T cells induced toxic shock syndrome toxin-1 and their potential application in acute graft-versus-host disease, (Dr. Anthony Chow)

6) Matthew Martin, The Role of the Insulin-Like Growth Factor Signaling Axis in ETV6- NTRK3-Mediated Anchorage-Independent Growth and Transformation, (Dr. Poul Sorenson)

7) Michael Rauh, The role of SHIP in macrophage differentiation and function, (Dr. Gerry Krystal)

8) Ainsley Sutherland, Genetic Determinants of the Host Response to Infection in Critically Ill Adults with Systemic Inflammatory Response Syndrome, (Dr. James Russell)

9) Shih Wei Wang, Regulation of macrophage apoptosis via Bcl-2 family members and ceramide, (Dr. Vincent Duronio)

MSc Graduates

1) Chantal Cho, The role of germ-line immunoglobulins in autoimmunity and B cell activation, (Dr.John Schrader)

2) Jennifer Claydon, Through the Looking Glass: An Epidemiological Look at Maternal Risk Factors and Infant Outcomes in Canadian Neonatal Intensive Care Units, (Dr. Erik Skarsgard)

3) Valgerdur Gylfadottir, Telomere dynamics in hematopoetic stem cells, (Dr. Fabio Rossi)

4) Michael Kennah, Inhibition of the Phosphoinositide 3-kinase Pathway in Multiple Myeloma Mediated through Activation of SHIP, (Dr. Alice Mui)

5) Shaun Klassen, Nitric Oxide Induced Cardiomyocyte Cell Death, (Dr. Simon Rabkin)

6) Danbin Li, Bone Stromal Production of Insulin-like Growth Factor Binding Protein 5 Promotes Growth and Survival of Prostate Cancer, (Dr. Michael Cox)

7) Philip Ly, In vitro Analysis of the Biochemical Pathways Activated by Cholesteryl Glucoside in a Motor Neuron Hybrid Model of Amyotrophic Lateral Sclerosis- Parkinsonism Dementia Complex, (Dr. Christopher Shaw)

8) Philip Ng, The Expression of XAF1 in Melanoma and the Role of ILK in Melanoma Invasive Behavior, (Dr. Gang Li)

9) Kasandra Palmer, Correlation of in vivo positron emission tomography and in vitro autoradiography measurements using radiotracers for the dopamine system, (Dr. Doris Doudet)

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10) Soraya Utokaparch, Development of a Standardized Quantitative Real Time PCR Panel for Respiratory Viral Diagnosis, (Dr. James Hogg & Dr. Richard Hegele)

11) Xingji Zheng, Serine/Threonine Phosphorylation in Mycobacterium Tuberculosis: Substrates of PknH kinase, (Dr. Yossef Av-Gay)

In 2007, 102 Experimental Medicine students surveyed reported a total of $2,132,489 in funding, an average of $20,907 (up from $20,345 in 2006) per student. Research Supervisors provided $810,800 in Graduate Research Assistantships. Other funding sources included CIHR ($551,333, up from $368,800 in 2006), the Michael Smith Foundation ($270,000, up from $214,000 in 2006), and NSERC ($105,000, up from $55,800 in 2006).

There are 121 faculty members currently registered as Research Supervisors in the program. Faculty members from other departments also participate as course lecturers, thesis committee members, in research seminars and as examiners for internal examinations and theses defenses.

In the academic year 2006-2007, the Experimental Medicine Program offered eight graduate courses. These included: MEDI 501 (Molecular & Cellular Biology), MEDI 502 (Methodology), MEDI 530 (Gastroenterology), MEDI 535 (Journal Club), MEDI 548 (Directed Studies in Experimental Medicine), MEDI 560 (Pulmonary Pathophysiology), MEDI 570 (Cardiology), and MEDI 590 (Molecular Medicine).

The overall administration of the program is under the guidance of the Experimental Medicine Committee. The committee is composed of representatives from each subspecialty and one student representative. This committee meets at least once per year to discuss policy and procedures. Current members of the committee are: Dr. Yossef Av-Gay (Infectious Diseases), Dr. Vincent Duronio (Respiratory Medicine and Director), Dr. R. Keith Humphries (Haematology/Oncology), Dr. Gang Li (Dermatology), Dr. Steve Pelech (Molecular Medicine), Dr. Bill Salh (Gastroenterology), Dr. Andrew Sandford (Respiratory Medicine, iCapture Centre), Dr. Yu Tian Wang (Neurology, Brain Research Centre), and Dr. Graydon Meneilly (ex-officio). The Experimental Medicine Program’s daily administration is through the director and one secretary.

The Experimental Medicine Program continues to sponsor Student Research Day events, two of which were held in 2007.

The first Student Research Day of 2007 was held on June 15 at the Medical Student and Alumni Centre, VGH. 11 students gave oral presentations and 36 students participated in poster presentations.

Sarah Allan won Best Overall Presentation. Melisa Hamilton and Frann Antignano won Best Oral Presentations. Johnny Chen and Claudia Chavez-Muñoz won Best Poster Presentations. The total amount of prize money won was $600.

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The second Student Research Day of 2007 was held on November 30 at the Holiday Inn Vancouver Centre. 12 students gave oral presentations and 31 students participated in poster presentations.

Paxton Bach won the award for top overall presentation. Bernhard Lehnertz won Best Oral, Pol Gomez won Runner Up-Best Oral, Rena Tabata won Best Poster, and Reza Baradar Jalili won Runner Up-Best Poster The total amount of prize money won was $700.

Financial support for the Student Research Day events was provided by the Vancouver Coastal Health Research Institute, GlaxoSmithKline Inc., Merck Frosst Canada and Co., and the Canadian Society of Biochemistry, Molecular and Cellular Biology.

The Experimental Medicine Program continued to offer travel grants to students who had already used the travel grant provided by the Faculty of Graduate Studies.

The Experimental Medicine Office is located at the UBC Department of Medicine, 10th Floor, Room 10226, Gordon and Leslie Diamond Health Care Centre, 2775 Laurel Street, Vancouver General Hospital. The office telephone number is 604-875-4111-ext.63140, the fax number is 604-875-4886 and e-mail address is [email protected].

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POSTGRADUATE EDUCATION PROGRAM

Dr. James Mark Roberts Clinical Associate Professor & Director

New Initiatives/Developments

In January 2007 Dr. Rose Hatala stepped down as an Associate Program Director. She was replaced by Dr. Irene Ma who has now taken over the portfolio responsible for resident evaluation/remediation as well as development of the Simulator Project.

In February 2007 the program underwent a Royal College Accreditation Review where we received full approval.

Our Annual Whistler Retreat was held March 7 – 9, 2007 where approximately 70 residents participated. This year’s focus was “Contemporary Issues in Medicine: Challenges & Opportunities.

The Annual resident Research Day was held on May 23rd with 30 podium presentations by residents and 24 poster presentations. Moderator for this year was Dr. Sharlene Gill. Podium adjudicators were Dr. Ken. Atkinson, Chief of Medicine, Royal Columbian Hospital; Dr. Finlay McAlister – a general internist – who is a CIHR New Investigator and a Population Health Scholar of the Alberta Heritage Foundation for Medical Research; and Dr. Kurt Williams, Program Director for the University of Saskatchewan, Internal Medicine Residency Training Program. Poster adjudicators were Dr. Anthony Chow - Professor Emeritus, UBC Department of Medicine and Dr. Richard Leather a Cardiologist with the Royal Jubilee Hospital in Victoria.

July 2007 saw the largest number of MOH funded residency positions to-date. With 39 PGY-1 positions through CaRMS, 2 re-entry physicians and 3 sponsored Internal Medical Graduates we continue to be the second largest Internal Medicine Training Program in Canada.

In July 2007 two additional Clinical Teaching Sites were developed at Royal Columbian Hospital under the supervision of Dr. Gerald da Roza. We also expanded our community rotations to include Penticton which has developed into an excellent teaching site. As well, a General Internal Medicine Ambulatory Clinic, under the direction of Dr. Jim Busser, has been developed for our PGY3 residents.

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Our second Annual Resident Day on Quality Improvement was held November 28, 2007. This year we were pleased to have the following adjudicators: Dr. Greg Ogrnic, Assistant Dean & Director for Research & Innovation in Medical Education, Dartmouth Medical School, USA; Dr. Graydon Meneilly, Head UBC Department of Medicine; Colleen Drain, Executive Director, QUIST/Decision Support for Vancouver Acute, VCH; and Barbara Trerise, Chief Patient Safety & Performance Improvement Office for Province Healthcare.

In December Dr. Roger Wong began working on development of an advocacy component to the program. A pilot project will be run in January 2008 which will consist of resident participation at a talk to the Chinese Community in East Vancouver. Residents have been recruited to take blood pressure readings of all participants.

The Postgraduate Program continues to face many challenges with respect to the medical school expansion. We continue to develop additional subspecialty rotations both within the Lower Mainland as well as other areas within BC. Scheduling an extremely high volume of rotations for both core residents and external residents continues to prove challenging. We do have significant issues surrounding monitoring of resident wellness in such a large program. Adequate resources, at the Faculty of Medicine level, need to be developed for residents in both academic and psychological distress. With our large program it is a challenge to maintain the cohesiveness that may exist in smaller programs and we continue to work hard to ensure we maintain a cohesive and collegial environment for all of our residents.

UBC Department of Medicine Page 188 Annual Report 2007

UNDERGRADUATE EDUCATION PROGRAM

Dr. H. Grant Stiver Professor & Director

The Department of Medicine Undergraduate Medical Education Program Office is located in the Gordon and Leslie Diamond Health Care Centre (GLDHCC). The Department currently consists of 17 divisions overseen by Division Heads, as well as, site-specific Division Heads: AIDS, Allergy and Immunology, Cardiology, Community General Internal Medicine, Critical Care, Endocrinology, Gastroenterology, Geriatric Medicine, General Internal Medicine, Haematology, Infectious Diseases, Medical Oncology, Nephrology, Neurology, Physical Medicine & Rehabilitation, Respiratory Medicine and Rheumatology. All Divisions are engaged in undergraduate teaching.

The Department of Medicine Undergraduate Medical Education Program is a distributed program with satellite offices in Chilliwack (Chilliwack Integrated Clerkship), Prince George (Northern Medical Program (NMP)), and Victoria (Island Medical Program (IMP)). The IMP and NMP each have 24 medical students in the Undergraduate Medical Education Program in the 3rd year Clinical Clerkship.

The Department of Medicine Vancouver Fraser Medical Program (VFMP) encompasses second, third and fourth year medical students.

January through May, second year UBC medical students participate in a four-week bedside teaching course. These sessions are part of the Clinical Skills Course (INDE 420) and continue to be one of the highest rated sessions in the undergraduate curriculum. Students are assigned a patient and perform a complete and focused history and physical examination, reviewed at the bedside by a clinician instructor who also critiques the student’s write-up of the case. As of January 2008, there are approximately 178 medical students in the second year class. Students are now deployed between nine different sites throughout the Lower Mainland, including Burnaby General Hospital, the Fraser Valley Cancer Centre and Royal Columbian Hospital!

September to August, the third year clinical clerkship rotation consists of an eight-week rotation, including Thursday afternoon academic half-days, Chief Medical Resident teaching sessions and a Neurology Bedside Teaching session. The third year clinical clerkship differs considerably from the second year in that the objectives are not only to further the medical knowledge and skill of the student in clinical diagnosis, but also to have the student learn to manage patients’

UBC Department of Medicine Page 189 Annual Report 2007

problems and provide daily overall care to the ill patient. As of September 2007, there are approximately 145 medical students in the third year class. The written examination at the end of each clinical clerk’s rotation continues to be the National Board of Medical Examiners (NBME) shelf examination in Medicine. The performance of UBC first-time examinees of the NBME exam in Medicine (all clerkship rotations) during the 2006-07 academic year resulted in a mean subject exam test score of 74.0. The mean for North American medical schools which have an eight-week clerkship was 74.9. The performance of students beginning the clerkship at the end of Third Year generally increased compared with the performance of students beginning in September, reflecting the increased clinical experience acquired throughout the year.

In year four, UBC medical students undertake a series of elective rotations. In 2007 the Undergraduate Dean’s Office increased the amount of clinical elective time. UBC 4th year medical students have elective time during the months of September, October and November, as well as January, March and April. Our Program continues to offer a wide range of sub-specialty rotations, including elective opportunities within the Island Medical Program and the Northern Medical Program. Approximately 70% of fourth year UBC medical students undertake at least one of these sub-specialty rotations. As of September 2007, there are approximately 202 medical students in the fourth year class. Elective opportunities are also offered to out-of-province medical students and in 2007 our Program processed and confirmed 142 out-of-province elective applications.

In 2007, the Department of Medicine Undergraduate Program had many accomplishments and achievements:

• In January 2007, our Program was involved in the development and implementation of the new Year 4 Program and the coordination of the elective selection process for 4th year UBC medical students via the WebEval system. • In February 2007, the Undergraduate Education Program engaged in discussions with Royal Columbian Hospital (RCH) and the Department of Medicine Postgraduate Program regarding opportunities to send both medical students and medical residents to RCH commencing September 2007. • Dr. Janet Kushner Kow and Jennifer Golinski attended the 1st Inaugural Clinical Clerkship Directors and Administrators workshop as part of The Association of Faculties of Medicine of Canada (AFMC) conference in Victoria in May 2007. It was an incredible opportunity to network with Clerkship Directors and Administrators across Canada. • Members of the Undergraduate Education Committee met in May 2007 to discuss both short and long terms goals of the Program, specifically the 3rd year Clinical Clerkship. To support the increase in numbers of students commencing September 2007, a four-week General Internal Medicine rotation at UBC Hospital will be included as part of the 3rd year Clinical Clerkship. • The Program welcomed Sigal Stein as the new Program Assistant at St. Paul’s Hospital site, commencing July 2007.

UBC Department of Medicine Page 190 Annual Report 2007

Medical School Expansion In September 2007, the Department of Medicine third year clinical clerkship expanded to include an additional 24 third year medical students in the Vancouver Fraser Medical Program.

In 2008, the Undergraduate Program will continue to collaborate with expanded programs in Prince George and in Victoria to support clerkship rotations during the 2007-08 academic year and continue to expand the current Internal Medicine Electives’ Program to include additional sites throughout British Columbia.

UBC Department of Medicine Page 191 Annual Report 2007

PUBLICATIONS

UBC Department of Medicine Page 193 Annual Report 2007

AIDS

Harrigan, Dr. Paul R Galli R, Wynhoven B, Harrigan P. Quality management of sequence-based methods for measuring HIV-1 drug resistance. Am Clin Lab. 2002 Jan-Feb;21(1):13-5. Wood E, Hogg RS, Yip B, Harrigan PR, Montaner JS. Using baseline CD4 cell count and plasma HIV RNA to guide the initiation of highly active antiretroviral therapy. Rev Invest Clin. 2004 Mar-Apr;56(2):232-6. Cheung PK, Wynhoven B, Harrigan PR. 2004: which HIV-1 drug resistance mutations are common in clinical practice? AIDS Rev. 2004 Apr-Jun;6(2):107-16. Wood E, Hogg R, Yip B, Moore D, Harrigan P, Montaner J. Superior virological response to boosted protease inhibitor-based highly active antiretroviral therapy in an observational treatment programme. HIV Med. 2007 Mar;8(2):80-5. Tam L, Hogg R, Yip B, Montaner J, Harrigan P, Brumme C. Performance of a World Health Organization first-line regimen (stavudine/lamivudine/nevirapine) in antiretroviral-naive individuals in a Western setting. HIV Med. 2007 Jul;8(5):267-70. Bertagnolio S, Soto-Ramirez L, Pilon R, Rodriguez R, Viveros M, Fuentes L, Harrigan PR, Mo T, Sutherland D, Sandstrom P. HIV-1 drug resistance surveillance using dried whole blood spots. Antivir Ther. 2007;12(1):107-13. Larder B, Wang D, Revell A, Montaner J, Harrigan PR, De Wolf F, Lange J, Wegner S, Ruiz L, Perez-Elias MJ, Emery S, Gatell, J, Monforte AD, Torti C, Zazzi M, Lane C. The development of artificial neural networks to predict virological response to combination HIV therapy. Antivir Ther. 2007;12(1):15-24. Brumme ZL, Brumme CJ, Heckerman D, Korber BT, Daniels M, Carlson J, Kadie C, Bhattacharya T, Chui C, Szinger J, Mo T, Hogg RS, Montaner JS, Frahm N, Brander C, Walker BD, Harrigan PR. Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1. PLoS Pathog. 2007 Jul 6;3(7):e94 Phillips E, Gutierrez S, Jahnke N, Yip B, Lima VD, Hogg RS, Harrigan PR, Montaner JS. Determinants of nevirapine hypersensitivity and its effect on the association between hepatitis C status and mortality in antiretroviral drug-naïve HIV-positive patients. AIDS. 2007 Jul 31;21(12):1561-8. Harrigan PR, Mo T, Hirsch J, Brumme ZL, McKenna P, Bacheler L. A 21-Base Pair Insertion/Duplication at Codon 69 of the HIV Type 1 Reverse Transcriptase in a Patient Undergoing Multiple Nucleoside Therapy. AIDS Res Hum Retroviruses. 2007 Jul;23(7):895-9. Low AJ, Dong W, Chan D, Sing T, Swanstrom R, Jensen M, Pillai S, Good B, Harrigan PR. Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates. AIDS. 2007 Sep;21(14):F17-F24. Harrigan PR, Mo T, Hirsch J, Brumme ZL, McKenna P, Bacheler L. 21-base pair insertion/duplication at codon 69 of the HIV type 1 reverse transcriptase in a patient undergoing multiple nucleoside therapy. AIDS Res Hum Retroviruses. 2007 Jul;23(7):895-9 Low AJ, Dong W, Chan D, Sing T, Swanstrom R, Jensen M, Pillai S, Good B, Harrigan PR. V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates. AIDS. 2007 Sep 12;21(14):F17-24 Brumme ZL, Chui C, Brumme C, Harrigan PR. A Simple Screening Approach to Reduce B*5701-Associated Abacavir Hypersensitivity on the Basis of Sequence Variation in HIV Reverse TranscriptaseClin Infect Dis. 2007 Nov 1;45(9):1244-1245 Sing T, Low AJ, Beerenwinkel N, Sander O, Cheung PK, Domingues FS, Büch J, Däumer M, Kaiser R, Lengauer T, Harrigan PR. Predicting HIV coreceptor usage on the basis of genetic and clinical covariates. Antivir Ther. 2007;12(7):1097-106. Low AJ, Dong W, Chan D, Sing T, Swanstrom R, Jensen M, Pillai S, Good B, Harrigan PR. Current V3 genotyping algorithms are inadequate for predicting X4 co-receptor usage in clinical isolates. AIDS. 2007 Sep 12;21(14):F17-24. UBC Department of Medicine Page 194 Annual Report 2007

Brumme CJ, Harrigan PR, Preston EC, Dong WW, Wynhoven B, Murphy C, Montaner JS. Transmission of drug-resistant HIV-1 from an infected individual to a caregiver. Antivir Ther. 2007;12(7):1139-44. Yap SH, Sheen CW, Fahey J, Zanin M, Tyssen D, Lima VD, Wynhoven B, Kuiper M, Sluis-Cremer, Harrigan PR, Tachedjian G. N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. PLoS Med. 2007 Dec;4(12):e335.

Kerr, Dr. Thomas H Maas B, Fairbairn N, Kerr T, Li K, Montaner JS, Wood E. Neighborhood and HIV infection among IDU: Place of residence independently predicts HIV infection among a cohort of injection drug users. Health & Place, 2007; 13(2): 432-439. Wood E, Lloyd-Smith E, Li K, Strathdee SA, Small W, Tyndall MW, Montaner JSG, Kerr T. Frequent needle exchange use and HIV incidence in Vancouver, Canada. American Journal of Medicine, 2007; 120(2): 172-179. Kerr T, Fairbairn N, Tyndall M, Marsh D, Li K, Montaner J, Wood E. Predictors of non-fatal overdose among a cohort of polysubstance-using injection drug users. Drug and Alcohol Dependence, 2007; 87(1): 39-45. Kerr T, Tyndall M, Zhang R, Montaner J, Wood E. Circumstances of first injection among illicit drug users using a medically supervised safer injection facility. American Journal of Public Health, 2007 Jul;97(7):1228-30. Petrar S, Kerr T, Tyndall MW, Zhang R, McKnight B, Montaner JSG, Wood E. Injection drug users’ perceptions regarding use of a medically supervised safer injecting facility. Addictive Behaviors, 2007; 32(5): 1088-93. Wood E, Hogg RS, Kerr T, Bonner S, Strathdee SA, Palepu A, Montaner JSG. Rates of inappropriate antiretroviral prescription among injection drug users. Harm Reduction Journal, 2007; 4(1): 2. Miller CL, Kerr T, Strathdee SA, Li K, Wood E. Factors associated with premature mortality among young injection drug users in Vancouver. Harm Reduction Journal, 2007; 4(1): 1. Kerr T, Small W, Moore D, Wood E. A micro-environmental intervention to reduce the harms associated with drug-related overdose: evidence from the evaluation of Vancouver’s safer injection facility. International Journal of Drug Policy, 2007;18(1): 37-45. Stoltz JA, Wood E, Small W, Li K, Tyndall M, Montaner J, Kerr T. Changes in injecting practices associated with the use of a medically supervised safer injection facility. Journal of Public Health (Oxford, England), 2007 Jan 17 [Epub ahead of print]. Kerr T, Kimber J, Rhodes T.Drug use settings: an emerging focus for research and intervention. International Journal of Drug Policy, 2007; 18(1): 1-4. Small W, Rhodes T, Wood E, Kerr T. Public injection settings in Vancouver: physical environment, social context and risk. International Journal of Drug Policy, ;18(1): 27-36. Tyndall MW, McNally M, Lai C, Zhang R, Wood E, Kerr T, Montaner JG. Directly observed therapy programmes for antiretroviral treatment amongst injection drug users in Vancouver: access, adherence and outcomes. International Journal of Drug Policy, 2007 Aug;18(4):281-7. McKnight I, Maas B, Wood E, Tyndall MW, Small W, Lai C, Montaner JSG, Kerr T. Factors associated with public injecting among users of Vancouver’s supervised injection facility. American Journal of Drug and Alcohol Abuse, 2007;4(1): 1. Wood E, Tyndall MW, Zhang R, Montaner JSG, Kerr T. Rate of detoxification service use and its impact among a cohort of supervised injecting facility users. Addiction, 102(6)916-9. Lima VD, Hogg RS, Bangsberg D, Montaner JSG, Geller J, Daniel M, Kerr T, Patterson T. The effect of adherence on the association between depressive symptoms and mortality among HIV infected individuals first initiating HAART. AIDS, 2007, 21(9) 1175-1183. Wood E, Montaner JS, Li K, Barney L, Tyndall MW, Kerr T. Rate of methadone use among Aboriginal opioid injection drug users. CMAJ. 2007 Jul 3;177(1):37-40.

UBC Department of Medicine Page 195 Annual Report 2007

Wood E, Kerr T, Montaner JS. HIV treatment, injection drug use, and illicit drug policies. Lancet. 2007 Jul 7;370(9581):8-10. Marshall B, Wood E, Li K, Kerr T. Elevated syringe sharing among men who have sex with men: a prospective study. J Acquir Immune Defic Syndr. 2007 Aug 2;[Epub ahead of print] Wood E, Kerr T, Zhang R, Tyndall M, Montaner JS. Rates of HIV/AIDS care and antiretroviral therapy response among active injection drug users. Addiction. 2007 Sep;102(9):1503-5. Stoltz JA, Shannon K, Kerr T, Zhang R, Montaner JS, Wood E. Associations between childhood maltreatment and sex work in a cohort of drug-using youth. Soc Science and Medicine. 2007 Sep;65(6):1214-21. Rachlis B, Brouwer KC, Mill Ej, Jayes M, Kerr T, Hogg R. Migration and transmission of blood-borne infections among injection drug users: Understanding the epidemiologic bridge. Drug Alcohol Dependence, 2007 Oct 8;90(2-3):107-19. Marshall B, Wood E, Li K, Kerr T. Elevated syringe borrowing among men who have sex with men: a prospective study. Journal of Acquired Immune Deficiency Syndromes. 2007 Oct 1;46(2):248-52. Kerr T, Kimber J, DeBeck K, Wood E. The role of safer injection facilities in response to HIV/AIDS among injection drug users. Current Medicine Group. 2007 Nov 7; 4 (4):158-164. DeBeck K, Shannon K, Wood E, Li K, Montaner JS, Kerr T. Income generating activities of people who inject illicit drugs. Drug and Alcohol Dependence. 2007 Nov 2;91(1):50-6. Kerr T, Kimber J, DeBeck K, Wood E. The Role of Safer Injection Facilities in the Response to HIV/AIDS Among Injection Drug Users. Current HIV/AIDS Reports. 2007, 4(4), 158-164.

Montaner, Dr. Julio S • Brumme ZL, Brumme CJ, Chui C, Mo T, Wynhoven B, Woods CK, Henrick BM, Hogg RS, Montaner JS, Harrigan PR. Effects of human leukocyte antigen class I genetic parameters on clinical outcomes and survival after initation of highly active antiretroviral therapy. J Infect Dis 2007;195(11):1694-704. • Brumme CJ, Harrigan PR, Preston E, Dong WWY, Wynhoven B, Murphy C, Montaner JSG. Transmission of drug-resistant HIV-1 from an infected individual to a caregiver. Antivir Ther 2007;12(7):1139-44. Christie T, Asrat GA, Jiwani B, Maddix T, Montaner JS. Exploring disparities between global HIV/AIDS funding and recent tsunami relief efforts: An ethical analysis. Developing World Bioeth 2007;7(1):1-7. Chui CKS, Brumme ZL, Brumme CJ, Yip B, Phillips EJ, Montaner JSG, Harrigan PR. A simple screening approach tto reduce B*5701-associated abacavir hypersensitivity on the basis of sequence variation in HIV reverse transcriptase. Clin Infect Dis 2007;44(11):1503-08. Debeck K, Shannon K, Wood E, Li K, Montaner J, Kerr T. Income generating activities of people who inject drugs. Drug Alcohol Depend. 2007;91(1):50-6. Ezzat H, Filipenko D, Vickars L, Galbraith P, Li C, Murphy K, Montaner JSG, Harris M, Hogg RS, Vercauteren S, Leger CS, Zypchen L, Leitch HA. Improved survival in HIV-associated diffuse large B-cell lymphoma with the addition of Rituximab to chemotherapy in patients receiving highly active antiretroviral therapy. HIV Clin Trials 2007;8(3):132-44. Fairbairn N, Kerr T, Buxton JA, Li K, Montaner JS, Wood E. Increassing use and associated harms of crystal methamphetamine injection in a Canadian setting. Drug Alcohol Depend 2007;88(2-3):313-16. Hoen B, Cooper DA, Lampe FC, Perrin L, Clumeck N, Phillips AN, Goh L, Lindback S, Sereni D, Gazzard B, Montaner J, Stellbrink H, Lazzarin A, Ponscarme D, Staszewski S, Mathiesen L, Smith D, Finlayson R, Weber R, Wegmann L, Janossy G, Kinloch-de Loes S, for the QUEST Study Group. Predictors of virological outcome and safety in primary HIV type 1-infected patients initiating quadruple antiretroviral therapy: QUEST GW PROB3005. CID 2007;45:381-90. Kerr T, Fairbairn N, Tyndall M, Marsh D, Li K, Montaner J, Wood E. Predictors of non-fatal overdose among a cohort of polysubstance-using injection drug users. Drug Alcohol Depend 2007;87(1):39-45.

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Kerr T, Tyndall MW, Zhang R, Lai C, Montaner JS, Wood E. Circumstances of first injection among illicit drug users accessing a medically supervised safer injection facility. Am J Public Health 2007;97(7):1228-30. Larder B, Wang D, Revell A, Montaner J, Harrigan R, De Wolf F, Lange J, Wegner S, Ruiz L, Perez-Elias MJ, Emery S, Gatell J, Monforte AD, Torti C, Zazzi M, Lane C. The development of artificial neural networks to predict virological response to combination HIV therapy. Antivir Ther 2007;12(1):15-24. Lazzarin A, Campbell T, Clotet B, Johnson M, Katlama C, Moll A, Towner W, Trottier B, Peeters M, Vingerhoets J, de Smedt G, Baeten B, Beets G, Sinha R, Woodfall B, on behalf of the DUET-2 study group (JSG Montaner-Investigator). Lancet 2007;370-39-48. Lima VD, Hogg RS, Harrigan PR, Moore D, Yip B, Wood E, Montaner JS. Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS 2007;21(6):685-92. Lima VD, Geller J, Bangsberg DR, Patterson TL, Daniel M, Kerr T, Montaner JS, Hogg RS. The effect of adherence on the association between depressive symptoms and mortality among HIV-infected individuals first initiating HAART. AIDS 2007;21(9):1175-83. Lima VD, Hogg RS, Montaner JS. Presenting plasma HIV RNA level and rate of CD4 T-cell decline. JAMA 2007;297(8):805-6; author reply 806-7. Madruga JV, Cahn P, Grinsztejn B, Haubrich R, Lalezari J, Mills A, Pialoux G, Wilkin T, Peeters M, Vingerhoets J, de Smedt G, Leopold L, Trefiglio R, Woodfall B, on behalf of the DUET-1 study group (JSG Montaner-Investigator). Lancet 2007;370:29-38. McKnight I, Maas B, Wood E, Tyndall MW, Small W, Lai C, Montaner JS, Kerr T. Factors associated with public injecting among users of Vancouver's supervised injection facility. Am J Drug Alcohol Abuse2007;33(2):319-25. Nelson MR, Katlama C, Montaner JS, Cooper DA, Gazzard B, Clotet B, Lazzarin A, Schewe K, Lange J, Wyatt C, Curtis S, Chen S, Smith S, Bischofberger N, Rooney JF for the Tenofovir DF Expanded Access Team. The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years. AIDS 2007;21(10):1273-81. Phillips E, Gutierrez S, Jahnke N, Yip B, Lima VD, Hogg RS, Harrigan PR, Montaner JSG. Determinants of nevirapine hypersensivity and its effect on the association between hepatitis C status and mortality in antiretroviral drug-naive HIV-positive patients. AIDS 2007;21(12):1561-68. Reynes J, Arasteh K, Clotet B, Cohen C, Cooper DA, Delfraissy JF, Eron JJ, Henry K, Katlama C, Kuritzkes DR, Lalezari JP, Lange J, Lazzarin A, Montaner JS, Nelson M, O' Hearn M, Stellbrink HJ, Trottier B, Walmsley SL, Buss NE, Demasi R, Chung J, Donatacci L, Guimaraes D, Rowell L, Valentine A, Wilkinson M, Salgo MP. TORO: Ninety-Six-Week Virologic and Immunologic Response and Safety Evaluation of Enfuvirtide with an Optimized Background of Antiretrovirals. AIDS Patient Care STDS 2007:21(8):533-43. Stoltz J, Wood E, Small W, Li K, Tyndall M, Montaner JS, Kerr T. Changes in injecting practices associated with use of a medically supervised safer injection facility. J Public Health 2007;29(1):35- 39. Stoltz JA, Shannon K, Kerr T, Zhang R, Montaner JS, Wood E. Associations between childhood maltreatment and sex work in a cohort of drug-using youth. Soc Sci Med 2007;65(6):1214-21. Tyndall MW, McNally M, Lai C, Zhang R, Wood E, Kerr T, Montaner JG. Directly observed therapy programmes for anti-retroviral treatment amongst injection drug users in Vancouver: access, adherence and outcomes. Int J Drug Policy 2007;18(4):281-7. Wood E, Tyndall MW, Zhang R, Montaner JS, Kerr T. Rate of detoxification service use and its impact among a cohort of supervised injecting facility users. Addiction. 2007;102(6):916-9. Wood E, Lloyd-Smith E, Li K, Strathdee SA, Small W, Tyndall MW, Montaner JS, Kerr T. Frequent needle exchange use and HIV incidence in Vancouver, Canada. Am J Med 2007;120(2):172-79. Wood E, Hogg RS, Kerr T, Bonner S, Strathdee SA, Palepu A, Montaner JSG. Rates of inappropriate antiretroviral prescription among injection drug users. Harm Reduction J 2007;4(1):2.

UBC Department of Medicine Page 197 Annual Report 2007

Wood E, Kerr T, Tyndall MW, Zhang R, Hogg RS, Strathdee SA, Montaner JS. Rates of HIV/AIDS care and antiretroviral therapy response among active injection drug users. Addiction 2007;102(9):1503-5. Wood E, Montaner JS, Li K, Barney L, Tyndall MW, Kerr T. Rate of methadone use among Aboriginal opioid injection drug users. CMAJ 2007;177(1):37-40. Wood E, Montaner JS. When to initiate HIV antiretroviral therapy: do benefits other than survival deserve greater attention? J Acquir Immune Defic Syndr 2007;45(2):131-2. Wood E, Kerr T, Montaner JS. HIV treatment, injection drug use, and illicit drug policies. Lancet

Wood, Dr. Evan Maas B, Fairbairn N, Kerr T, Li K, Montaner JS, Wood E. Neighborhood and HIV infection among IDU: place of residence independently predicts HIV infection among a cohort of injection drug users. Health & Place, 2007; 13(2): 432-439. Fairbairn N, Kerr T, Buxton JA, Li K, Montaner JS, Wood E. Increasing use and associated harms of crystal methamphetamine injection in a Canadian setting. Drug and Alcohol Dependence, 2007; 88(2- 3): 313-6. Kerr T, Fairbairn N, Tyndall M, Marsh D, Li K, Montaner J, Wood E. Predictors of non-fatal overdose among a cohort of polysubstance-using injection drug users. Drug and Alcohol Dependence, 2007; 87(1): 39-45. Kerr T, Tyndall M, Zhang R, Lai C, Montaner J, Wood E. Circumstances of first injection among illicit drug users using a medically supervised safer injection facility. American Journal of Public Health. 2007 Jul; 97(7):1228-30. Wood E, Lloyd-Smith E, Li K, Strathdee SA, Small W, Tyndall MW, Montaner JSG, Kerr T. Frequent needle exchange use and HIV incidence in Vancouver, Canada. American Journal of Medicine, 2007; 120(2): 172-179. Miller CL, Kerr T, Strathdee SA, Li K, Wood E. Factors associated with premature mortality among young injection drug users in Vancouver. Harm Reduction Journal, 2007; 4(1): 1. Stoltz JA, Wood E, Small W, Li K, Tyndall M, Montaner JS, Kerr T. Changes in injecting practices associated with use of a medically supervised safer injection facility. Journal of Public Health (Oxford, England), 2007; 29(1); 35-9. Wood E, Tyndall MW, Zhang R, Montaner JSG, Kerr T. Rate of detoxification service use and its impact among a cohort of supervised injecting facility users. Addiction, 2007; 102(6)916-9. DeBeck K, Shannon K, Wood E, Li K, Montaner J, Kerr T. Income generating activities of people who inject illicit drugs. Drug and Alcohol Dependence. 2007 Nov 2;91(1):50-6. Wood E, Hogg RS, Kerr T, Bonner S, Strathdee SA, Palepu A, Montaner JSG. Rates of inappropriate antiretroviral prescription among injection drug users. Harm Reduction Journal, 2007; 4(1): 2. Kerr T, Small W, Moore D, Wood E. A micro-environmental intervention to reduce the harms associated with drug-related overdose: evidence from the evaluation of Vancouver’s safer injection facility. International Journal of Drug Policy, 2007;18: 37-45. Hill A, Wood E. Balancing effectiveness and access to HIV treatment in the developing world. AIDS, 2007; 21: 361-363. Small W, Rhodes T, Wood E, Kerr T. Public injection settings in Vancouver: physical environment, social context and risk. International Journal of Drug Policy, 2007;18: 27-36. Tyndall MW, McNally M, Lai C, Zhang R, Wood E, Kerr T, Montaner JG. Directly observed therapy programmes for antiretroviral treatment amongst injection drug users in Vancouver: access, adherence and outcomes. International Journal of Drug Policy. 2007 Aug;18(4):281-7. Lima VD, Yip B, Hogg RS, Moore D, Montaner JSG, Wood E, Harrigan PR. Continued improvement in survival among HIV infected individuals with newer forms of highly active antiretroviral therapy (HAART). AIDS, 2007;21(6):685-692. Wood E, Kerr T, Zhang R, Tyndall M, Montaner JSG. Rates of HIV/AIDS care and antiretroviral therapy response among active injection drug users. Addiction. 2007 Sep;102(9):1503-5.

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Wood E, Montaner JSG. When to initiate HIV antiretroviral therapy: Do benefits other than survival deserve greater attention? Journal of Acquired Immune Deficiency Syndromes. 2007 Jun 12;45(2):131-2. Wood E. Gender and risk factors for initiation into injection drug use. Drug Alcohol Review, 2007; 26(3): 333-34. Wood E, Kerr T, Montaner J. HIV treatment, injection drug use, and illicit drug policies. Lancet. 2007; 370(9581):8-10. Wood E, Montaner JS, Li k, Barney L, Tyndall MW, Kerr T. Rate of methadone use among Aboriginal opioid injection drug users. CMAJ. 2007; 177(1):37-40. Stoltz JA, Shannon K, Kerr T, Zhang R, Montaner JS, Wood E. Associations between childhood maltreatment and sex work in a cohort of drug-using youth. Soc Science and Medicine. 2007 Sep;65(6):1214-21. Marshall B, Wood E, Li K, Kerr T. Elevated syringe borrowing among men who have sex with men: a prospective study. Journal of Acquired Immune Deficiency Syndromes. 2007 Oct 1;46(2):248-52. Kerr T, Kimber J, DeBeck K, Wood E. The Role of Safer Injection Facilities in the Response to HIV/AIDS Among Injection Drug Users. Current HIV/AIDS Reports. 2007, 4(4), 158-164.

ALLERGY & IMMUNOLOGY

Schellenberg, Dr. Robert R An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Pare PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 29:834-60, 2007. Small P, Frenkiel S, Becker A, Boisvert P, Bouchard J, Carr S, Cockcroft D, Denburg J, Desrosiers M, Gall R, Hamid Q, Hebert J, Javer A, Keith P, Kim H, Lavigne F, Lemiere C, Massoud E, Payton K, Schellenberg B, Sussman G, Tannenbaum D, Watson W, Witterick I, Wright E. Rhinitis: An executive summary of a practical and comprehensive approach to assessment and therapy. Journal of Otolaryngology. 36(SUPPL. 1):S1-S4. 2007. Small P, Frenkiel S, Becker A, Boisvert P, Bouchard J, Carr S, Cockcroft D, Denburg J, Desrosiers M, Gall R, Hamid Q, Hebert J, Javer A, Keith P, Kim H, Lavigne F, Lemiere C, Massoud E, Payton K, Schellenberg B, Sussman G, Tannenbaum D, Watson W, Witterick I, Wright E. Rhinitis: A practical and comprehensive approach to assessment and therapy. Journal of Otolaryngology. 36(SUPPL. 1):S5- S27. 2007. Schellenberg RR, Adachi JDR, Bowie D, Brown J, Guenther L, Kader T, Trope GE. Oral corticosteroids in asthma: A review of benefits and risks. Canadian Respiratory Journal 14:1C-7C. 2007.

Wong, Dr. H. C. George Wong HCG. Herbal medicine and psychiatric disorders. BC Med J 2007; 49(5):230-231.

CARDIOLOGY

Buller, Dr. Christopher E Dzavik V, Cotter G, Reynolds HR, Alexander JH, Ramanathan K, Stebbins AL, Hathaway D, Farkouh ME, Ohman EM, Baran DA, Prondzinsky R, Panza JA, Cantor WJ, Vered Z, Buller CE, Kleiman NS,

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Webb JG, Holmes DR, Parrillo JE, Hazen SL, Gross SS, Harrington RA, Hochman JS. Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. Eur Heart J. 2007;28:1109-16. Fleisher LA, Beckman JA, Brown KA, et al. ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): Developed in Collaboration With the American Society of Echocardiography, American Society ofclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 2007;116:1971-1996. Fleisher LA, Beckman JA, Brown KA, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 2007;116:e418-99. Levin A, Pate GE, Shalansky S, Al-Shamari A, Webb JG, Buller CE, Humphries KH. N-acetylcysteine reduces urinary albumin excretion following contrast administration: evidence of biological effect. Nephrol Dial Transplant. 2007;22:2520-4.

Cairns, Dr. John A Cairns JA. The coxibs and traditional nonsteroidal anti-inflammatory drugs (tNSAIDs): A current perspective on cardiovascular risks. Can J Cardiol. 2007; 23: 125-31.

Carere, Dr. Ronald G Ye J, Cheung A, Lichtenstein SV, Pasupati S, Carere RG, Thompson CR. Sinhal A, Webb JG. Six-month outcome of transcatheter aortic valve implantation in the initial seven patients. European Journal of Cardio-thoracic Surgery 31 (2007) 16-21. Rec’d Oct 3/06. Pasupati S, Humphries K, Alali A, Altwegg L, Lichtenstein S, Ye J, Cheung A, Thompson CR, Carere R, Moss R, Munt B, Lee M, Webb J. Balloon Expandable Aortic Valve (BEAV) Implantation. The first 100 Canadian procedures. Can J Cardiol 2007 Vol 23 Suppl C October: 177. Webb JG, Pasupati S, Humphries K, Thompson C, Altwegg L, Moss R, Sinhal A, Carere RG, Munt B, Ricci D, Ye J, Cheung A, Lichtenstein SV. Percutaneous Transarterial Aortic Valve Replacement in Selected High-Risk Patients With Aortic Stenosis. Circulation AHA 2007;116:000-000. Ye J, Cheung A, Lichtenstein SV, Pasupati S, Carere RG, Thompson CR. Sinhal A, Webb JG. Six-month outcome of transcatheter aortic valve implantation in the initial seven patients. Eur J Cardiothoracic Surg 2007;31:16-21.

Fung, Dr. Anthony Y Management Patterns in Relation to Risk Stratification Among Patients with Non-ST Elevation Acute Coronary Syndromes. Archives of Internal Medicine 2007; 106: 1009-1016.

Heilbron, Dr. Brett G Heilbron B, Andrews G, Isserow S, Forster B. Coronary Computed Tomographic Angiography in British Columbia: A Review. BCMJ 49:2, 78-84. 2007.

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Humphries, Dr. Karin H Pilote L, Dasgupta K, Guru V, Humphries KH, McGrath J, Norris N, et al. A Global View of Gender Specific Issues Related to Cardiovascular Disease. Can Med Assoc J 2007;176(6 Suppl):S1-S5. Guru V, Cox J, Ghali W, Grace SL, Humphries KH. Cardiac Care Delivery in Women and Men. Can Med Assoc J 2007;176(6 Suppl):S26-29. Humphries KH, Ghali W, Cox J, Guru V, Norris C. Outcomes of Cardiovascular Disease in Women and Men - Drug Therapy Post Admission. Can Med Assoc J 2007;176(6 Suppl):S33-S36. Schick BA, Laaksonen R, Frohlich JJ, Paiva H, Lehtimaki T, Humphries KH, Cote HC. Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated with High-Dose Simvastatin. Clin Pharmacol Ther. 2007; 81(5):650-3. Rinfret S, Abrahamowicz M, Tu J, Humphries K, Eisenberg MJ, Richard H, Austin PC, Pilote L. A population-based analysis of the class effect of beta-blockers after myocardial infarction. Am Heart J. 2007 Feb;153(2):224-30. Hudson M, Humphries K, Tu JV, Behlouli H, Sheppard R, Pilote L. Angiotensin II Receptor Blockers for the Treatment of Heart Failure: A Class Effect? Pharmacotherapy. 2007 Apr;27(4):526-34.

Ignaszewski, Dr. Andrew P Arnold JM, Howlett JG, Dorian P. Ducharme A, Gianetti N, Haddad H, Heckman GA, Ignaszewski A. Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation and use of biomarkers. Can J Cardiol 2007;23(1):21-45. Chandavimol M. Malek F, Ignaszewski A. Natural history of moderate to severe mitral regurgitation in patients with cardiomyopathy followed at tertiary care heart failure clinic. Int J. Cardiol 2007;115(2):e68-70. Zutz A. Ignaszewski, A, Bates J, Lear SA. Utilization of the Internet to deliver cardiac rehabilitation at a distance: a pilot study. Telemed J E Health.2007 Jun:13(3);323-30.

Mancini, Dr. G B John William E. Boden, Robert A. O’Rourke, Koon K. Teo, Pamela M. Hartigan, David J. Maron, William J. Kostuk, Merril Knudtson, Marcin Dada, Paul Casperson, Crystal L. Harris, Bernard R. Chaitman, Leslee Shaw, Gilbert Gosselin, Shah Nawaz, Lawrence M. Title, Gerald Gau, Alvin S. Blaustein, David C. Booth, Eric R. Bates, John A. Spertus, Daniel S. Berman, G.B. John Mancini, and William S. Weintraub, for the COURAGE Trial Research Group. Optimal Medical Therapy with or without PCI for Stable Coronary Disease. The New England Journal of Medicine 2007; 356(15): 1503-1516. Scott A Lear, Karen H. Humphries, Simi Kohli, Jiri J. Frohlich, C. Laird Birmingham, G.B. John Mancini. Visceral Adipose Tissue, a Potential Risk Factor for Carotid Atheroschlerosis: Results of the Multicultural Community Health Assessment Trial (M-CHAT) Stroke 2007;38;2422-2429; originally published online Aug 2, 2007; DOI: 10.1161/STROKEAHA.107.484113.

Mayo, Dr. John R MacNutt MJ, Guenette JA, Witt JD, Yuan R, MAYO JR, McKenzie DC. Intense hypoxic cycle exercise does not alter lung density in competitive male cyclists. European Journal of Applied Physiology. Published online: 12 January 2007. Kirkpatrick AW, Colistro R, Laupland KB, Fox DL, Konkin DE, Kock V, MAYO JR, Nicolaou S. Renal arterial resistive index response to intra-abdominal hypertension in a porcine model. Crit Care Med. 2007;35(1):207-213.

Ellis JD, MAYO JR. CT Evaluation of Traumatic Rupture of the Thoracic Aorta: An Outcome Study. Canadian Association of Radiology Journal. 2007;58(1):22-26.

UBC Department of Medicine Page 201 Annual Report 2007

Hodges AN, Sheel AW, MAYO JR, McKenzie DC. Human Lung Density is not Altered Following Normoxic and Hypoxic Moderate-Intensity Exercise: Implications for Transient Edema. J Appl Physiol. 2007 Apr 5; [Epub ahead of print).

Rabkin, Dr. Simon W Rabkin SW. Epicardial fat: Properties, function and relationship to obesity. Obesity Reviews. 8:253-61, 2007. Lanktree M, Cao H, Rabkin SW, Hanna A, Hegele RA. Three novel Imna mutations in patients with dunnigan-type familial partial lipodystrophy type 2 (fpld2). Clinical Genetics. 71(2):183-6, 2007. Rabkin SW. Is obesity a cardiovascular problem? Can J of CME 2007. Rabkin SW. Treatment of hypertension in stroke patients. Perspectives in Cardiology 23:23-25, 2007. Rabkin SW, Klassen SS. Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes. Nitric Oxide: Biology and Chemistry 16:347-9, 2007. Rabkin SW. Nitric oxide-induced cell death in the heart: the role of autophagy. Autophagy 3:347-349, 2007. Rabkin SW, Klassen SS. Omapatrilat enhances adrenomedullin's reduction in cardiomyocyte cell death. Euro J Pharm 562:174-82, 2007. Padwal RS, Hemmelgarn BR, McAlister FA, McKay DW, Grover S, Wilson T, Penner B, Burgess E, Bolli P, Hill M, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Khan NA, Rabkin SW, Dawes M, Touyz RM, Tobe SW; Canadian Hypertension Education Program. The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension; part 1 - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol. 2007;23:529-38. Khan NA, Hemmelgarm BR, Padwal R, Larochelle P, Mahon JL, Lewanczuk RZ, McAlister FA, Rabkin SW, Hill MD, Feldman RD, Schiffrin EL, Campbell NR, Logan AG, Arnold M, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Leiter LA, Ogilvie RI, Herman RJ, Hamet P, Fodor G, Carruthers G, Culleton B, Burns KD, Ruzicka M, deChamplain J, Pylypchuk G, Gledhill N, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Touyz RM, Tobe SW; Canadian Hypertension Education Program. The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension; part 2 - therapy. Can J Cardiol. 2007;23:539-50. Rabkin SW, Klassen SS, Tsang MY. Sodium nitroprusside activates p38 mitogen activated protein kinase through a cGMP/PKG independent mechanism. Life Sciences 81(8):640-6, 2007. Rabkin SW, Lodha P, Kong JY. Reduction of protein synthesis and statin-induced cardiomyocyte cell death. Cardiovascular Toxicology. 7(1):1-9, 2007. Klassen SS, Rabkin SW. The role of p53 in nitric oxide-induced cardiomyocyte cell death. DNA & Cell Biology. 26(7):465-75, 2007. Rabkin SW. Kappa endogenous opoids mediate the action of brain angiotension II to increase blood pressure. Neuropeptides 41(6):411-9, 2007.

Ramanathan, Dr. Krishnan Alexander J, Ramanathan K, TRIUMPH Investigator - TRIUMPH Randomized Study – Effect of Tilarginine Acetate in Patients with Acute Myocardial Infarction and Cardiogenic Shock. JAMA April 2007, 297 (15) 1657-1666. Dzavik V, Cotter G, Reynolds H, Alexander J, Ramanathan K, et al, Effect of Nitric Oxide Synthase Inhibition on Haemodynamics and Outcome of Patients with Persistant Cardiogenic Shock Complicating Acute Myocardial infarction: a Phase II Dose ranging Study Eur Heart Journal, ref. # Eur Heart J-O7-00090, May 2007; 28 (9):1109-16.

UBC Department of Medicine Page 202 Annual Report 2007

Saw, Dr. Jacqueline W Saw J, Brennan DM, Steinhubl SR, Bhatt DL, Mak KH, Fox K, Topol EJ, on behalf of the CHARISMA Investigators. Lack of evidence of a clopidogrel - statin interaction in the CHARISMA Trial. JACC 2007;50:291-5.

Thompson, Dr. Christopher R Ye J, Cheung A, Lichtenstein SV, Pasupati S, Carere RG, Thompson CR, Sinhal A, Webb JG. Six-month outcome of transapical transcatheter aortic valve implantation in the initial seven patients. Eur J Cardiothorac Surg. 2007;31(1):16-21. Humphries KH, Gao M, Pu A, Lichtenstein S, Thompson CR. Significant improvement in short-term mortality in women undergoing coronary artery bypass surgery (1991 to 2004). J Am Coll Cardiol. 2007;49(14):1552-8.

Webb, Dr. John G Ezekowitz JA, Théroux P, MD; Welsh R, Bata I, Webb J, Armstrong PW. Insights into the change in brain natriuretic peptide after STEMI: Why Should it be Better Than Baseline? Can J Physiol Pharmacol. 2007; 85: 173-178. Naqvi TZ, Buchbinder M, Zarbatany D, Webb J, Logan J, Molloy M, Balke G, Tieu T, Ainsworth R, Alfieri O, Maisano F. Edge-to-edge repair utilizing a percutaneous suture device in an animal model. Cathet Cardiovasc Interven 2007; 69:525-531. Love MP, Schampaert E, Cohen E, Webb J, Anderson T, Labinaz M, Tanguay JF, Dzavik V, Utilization of drug-eluting stents in Canada: a national survey by the Canadian Association of Interventional Cardiology. Can J Cardiol 2007; 23: 121-123. Dzavik V. … Webb JG, …Hochman J. The effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. Eur Heart J 2007; 28: 1109-1116 Webb JG, Pasupati S, Humphries K, Thompson C, Altwegg L, Moss R, Sinhal A, Carere RG, Munt B, Ricci D, Ye J, Cheung A, Lichtenstein SV. Percutaneous transarterial aortic valve replacement in selected high risk patients with aortic stenosis. Circulation 2007; 116: 755-763. Webb JG. Transcatheter valve in valve implants for failed prosthetic valves. Cathet Cardiovasc Intervent 2007; 70: 765-766. Jeger R, …Webb JG, Hochman JS. Hemodynamic parameters are prognostically important in cardiogenic shock but similar following early revascularization or initial medical stabilization - A report from the SHOCK Trial. Chest 2007; 132: 1794-1803. Webb JG, Block PC. Percutaneous repair of mitral regurgitation using coronary sinus devices. Cardiosource Rev J 2007; 16: 12-13.

Wong, Dr. Graham C GC Wong, NT Ayas. Clinical approaches to the diagnosis of acute heart failure. Curr Opin Cardiology 2007; 22: 207-213.

Yeung-Lai-Wah, Dr. John A Qi A, Kerr CR, Tung S, Yeung-Lai-Wah JA. Long-term durability of high voltage transvenous defibrillation leads with multilumen construction. PACE 2007 (revision).

COMMUNITY INTERNAL MEDICINE

Kang, Dr. Anna Ma IW, Khan NA, Kang A, Zalunardo N, Palepu A. “Systematic review identified suboptimal reporting and use of race/ethnicity in general medical journals.” J Clin Epidemiol 2007 Jun; 60(6):572-8.

UBC Department of Medicine Page 203 Annual Report 2007

Chia S.K., Speers CH, D’yachkova Y, Kang A, Malfair-Taylor S, Barnett J, Coldman A, Gelmon KA, O’reilly SE, Olivotto IA. “The impact of new chemotherapeutic and hormone agents on survival in a population-based cohort of women with breast cancer.” Cancer 2007 Sep 1; 110 (5):973-9.

Thomas, Dr. Chandra M Thomas, C M., Zhang, J., Lim, T.K, Scott-Douglas, N., Hons, R.B., Bemmelgard, B.R., Alberta Kidney Disease Network. Concentration of Heparin-Locking Solution and Risk of Central Venous Catheter Malfunction. ASAIO Journal, July-Aug 2007; 53 (4): 465-488.

CRITICAL CARE MEDICINE

Dodek, Dr. Peter M Keenan SP, Dodek P, Martin C, Priestap F, Norena M, Wong H. Variation in length of ICU stay after cardiac arrest: where you are is as important as who you are. Critical Care Medicine. 2007; 35: 836-841. Ayas NT, Norena M, Wong H, Chittock D, Dodek PM. Pneumothorax After Insertion of Central Venous Catheters in the Intensive Care Unit: Association with Month of Year and Week of Month. Quality and Safety in Health Care, 2007 16: 252-255. Mountain SA, Quon BS, Dodek P, Sharpe R, Ayas NT. The Impact of Housestaff Fatigue on Occupational and Patient Safety in the Intensive Care Unit. Lung, 2007 185: 203-209. Sinuff T, Cook D, Giacomini M, Heyland D, Dodek P. Facilitating Clinician Adherence to Guidelines in the Intensive Care Unit: A Multicenter, Qualitative Study. Critical Care Medicine. 2007; 35: 2083-2089. Sinuff T, Eva KW, Meade M, Dodek P, Heyland D, Cook D. Clinical practice guidelines in the intensive care unit: a survey of Canadian clinicians' attitudes. Canadian Journal of Anesthesia. 2007; 54: 728-736.

MacRedmond, Dr. Ruth MacRedmond RE, Greene CM, Dorscheid DR, McElvaney NG, O'Neill SJ. Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke. Respir Res. 2007 Nov 22;8:84.

Tsang, Dr. John Y Tsang JY, Lamm WJE, Hlastala MP. Endothelin receptor blockade does not improve hypoxemia following acute pulmonary thromboembolism. J Appl Physiol 2007; 102:762-771.

Walley, Dr. Keith R Walley KR, Russell JA. Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med 35(1):287-0, 2007. Manocha S, Russell JA, Sutherland AM, Wattanathum A, Walley KR. Fibrinogen-ß gene haplotype is associated with mortality in sepsis. J Infect. 2007 54(6):572-7, 2007. Tokunaga C, Bateman RM, Boyd, J, Wang Y, Russell JA, Walley KR. Albumin Resuscitation Improves Ventricular Contractility and Myocardial Tissue Oxygenation in Rat Endotoxemia. Crit Care Med 35(5):1341-7, 2007. Bateman RM, Tokunaga C, Kareco T, Dorscheid D, Walley KR. Myocardial hypoxia-inducible factor alpha, VEGf and GLUT1 gene expression is related to microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Circ Physiol. 2007; 293: H448 - H456.

UBC Department of Medicine Page 204 Annual Report 2007

ENDOCRINOLOGY

Finegood, Dr. Diane T Suskin, N.G., Heigenhauser, G., Afzal, R., Finegood, D., Gerstein, H.C., and McKelvie, R.S. The effects of exercise training on insulin resistance in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil 14(6): 803-808, 2007. Daar, A.S., Singer, P.A., Persad, D.L., Pramming, S.K., Matthews, D.R., Beaglehole, Alan Bernstein, R., Borysiewicz, L.K., Colagiuri, S., Ganguly, N., Glass, R.I., Finegood, D.T., Koplan, J., Nabel, N.G., Sarna, G., Sarrafzadegan, N., Smith, R., Yach, D.,and Bell, J. Grand Challenges in Chronic Non-Communicable Diseases: The top 20 policy and research priorities for conditions such as diabetes, stroke and heart disease. Nature 450: 494-496, 2007. Fraser, S., Strom, A., Wang, G., Finegood, D.T. Pronounced cytosolic aggregation of cellular prion protein in pancreatic ß-cells in response to hyperglycemia. Laboratory Investigation 87: 139-149, 2007. Finegood, D. T. Can We Improve Nutritional Health at an Affordable Price? Canadian Issues Journal: 46-52, Winter 2006. Marée, A. F., Kublik, R., Finegood, D.T., Edelstsein-Keshet, L. Modelling the onset of type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Phil Trans R. Soc A. 364: 1267-1282, 2006. O'Brien, B.A., Geng, X., Orteu, C.H.., Huang, Y., Ghoreishi, M., Zhang, Y., Bush, J.A., Li, G., Finegood, D.T., Dutz, J.P. A deficiency in the in vivo clearance of apoptotic cells is a feature of the NOD mouse. J. Autoimmun. 26: 104-115, 2006. Finegood, D. T. The Agenda for Obesity Research in Canada. Part of 2006 Canadian Clinical Practice Guidelines on the Management and Prevention of Obesity in Adults and Children. Canadian Medical Association Journal 176: 111-114, 2007.

Francis, Dr. Gordon A Garver, W.S., Francis, G.A., Jelinek, D., Shepherd, G., Flynn, J. Castro, G., Walsh-Vockley, C., Coppock, D.L., Pettit, K.M., Heidenreich, R.A., and Meaney, F.J. (2007). The national Niemann-Pick C1 disease database: Report of clinical features and health problems. American Journal of Medical Genetics 143, 1204-1211.

Fung, Dr. Michelle A Yakobuvich N, Thompson D, Fung M. Three Cases of Cytomegalovirus Infection Following Pancreatic Islet Transplantation. Accepted to appear in the June 2007 issue of Transplantation Proceedings. Al Ghofaili K, Fung M, Ao Z, Meloche M, Shapiro RJ, Warnock GL, Elahi D, Meneilly GS, Thompson DM. Effect of exenatide on B cell function after islet transplantation in type 1 diabetes. Transplantation 2007;83(1): 24-28.

Paty, Dr. Breay W Walter M, McDonald CG, Paty BW, Shapiro AM, Ryan EA, Senior PA. Short report: Prevalence of autoimmune diseases in islet transplant candidates with severe hypoglycemia and glycemic lability: previously undiagnosed celiac and autoimmune thyroid disease is identified by screening. Diabet Med 2007 Jan; 24: 161-165. Senior PA, Zeman M, Paty BW, Ryan EA, Shapiro, AM. Changes in renal function after clinical islet transplant: a four year observational study. Am J Transplant 2007 Jan; 7(1): 91-98.

UBC Department of Medicine Page 205 Annual Report 2007

Prior, Dr. Jerilynn C Richards JB, Leslie WD, Joseph L, Siminoski K, Hanley DA, Adachi JD, Brown JP, Morin S, Papaioannou A, Josse RG, Prior JC, Davison KS, Tenenhouse A, Goltzman D, and for the CaMos Research Group. Changes to Osteoporosis Prevalence According to Method of Risk Assessment. Journal of Bone Mineral Research 2007; 22: 228-2354. Prior JC, Nielson JD, Hitchcock CL, Williams LA, Vigna YM, Dean CB. Medroxyprogesterone and conjugated estrogen are equivalent for hot flushes--a one-year randomized double blind trial following premenopausal ovariectomy. Clinical Science. 2007;112(10); 517-525. Richards J B, Papaioannou A, Adachi JD, Joseph L, Whitson HE, Prior J C, Goltzman D, for the Canadian Multicentre Osteoporosis Study (CaMos) Research Group. Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture. Archives of Internal Medicine. 2007:167:188-194. Prior JC, Burdge D, Maan E. Fragility Fractures and Bone Mineral Density in HIV Positive Women: a case-control population based study. Osteoporosis International 2007:18 (10).1345-1353. Hopman WM, Leroux C, Berger C, Joseph L, Barr SI, Prior JC, Harrison M, Poliquin S, Towheed T, Anastassiades T, Goltzman D, CaMos Research Group. Changes in Body mass index in Canadians over a five-year period: Results of a prospective, population based study. BMC Public Health 2007; 7:150. Hopman WM, Lawrence J, Berger C, Poliquin S, Barr S, Prior JC, Anastassiades T, Towheed T. The Association Between Body Mass Index and Health-Related Quality of Life: Data from CaMos, a Stratified Population Study. Quality of Life Research.2007.16 (10) :1595-1603.

Sirrs, Dr. Sandra M Sirrs S, Laule Cornelia , Mädler Burkhard, Brief Elana E , Tahir Sumia A , Bishop Carole, and MacKay Alex L. Normal appearing white matter in subjects with phenylketonuria: water content, myelin water fraction, and metabolite concentrations. Radiology. 2007;242:236-43. Sirrs S and Clarke JTR. Algalsidase therapy for Fabry Disease. Expert Review of Endocrinology and Metabolism. 2007 2(20:147-54.

Tildesley, Dr. Hugh D Tildesley HD, Aydin C, Ignaszewski A, Strelzow J, Yu E, Bondy G. Sulfonylurea Therapy is Associated with Increased NT-proBNP levels in the Treatment of Type 2 Diabetes. International Journal of Cardiology. Feb. 2007, Vol 115 Issue 3 pp. 312-317. Billington E , Fraser T , Tawashy A , Tildesley HD. Carbohydrate Counting vs. Sliding Scale for Insulin Dosage Estimation. Canadian Journal of Diabetes. May 2007, 31(2) pp. 117-124.

Ur, Dr. Ehud Lau DC, Douketis JD, Morrison KM, Hramiak IM, Shama AM, Ur E: Obesity Canada Clinical Practice Guidelines Expert Panel. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. CMAJ 2007 Apr 10;176(8):S1-13. Brown R, Imran SA, Belsham DD, Ur E, Wilkinson M. Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3. Neuroendocrinology 2007;85(4):232-41. Imran SA, Ur E, Clark DB. Managing prolactin-secreting adenomas during pregnancy. Can Fam Physician 2007 Apr;53(4):653-8. Review. Wilkinson M, Brown R, Imran SA, Ur E. Adipokine gene expression in brain and pituitary gland. Neuroendocrinology 2007;86(3):191-209. Brown RE, Imran SA, Ur E, Wilkinson M. KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake. Mol Cell Endocrinol 2007;Nov 1.

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GASTROENTEROLOGY

Byrne, Dr. Michael F Ho JK, Mahmoudi N, Al-Ali J, Yoshida EM, Byrne MF. Duodenal Varices: A Rare Manifestation of Portal Hypertension. Internet Journal of Gastroenterology 2007; 5. Zandieh I, Byrne MF. Autoimmune pancreatitis: A review.World J Gastroenterol. 2007;13(47):6327-32. Corcoran PA, Atherton JC, Kerrigan SW, Wadstrom T, Murray FE, Peek RM, Fitzgerald DJ, Cox DM, Byrne MF. The effect of different strains of Helicobacter pylori on platelet aggregation. Can J Gastroenterol. 2007;21(6):367-70. Manning DS, Sheehan KM, Byrne MF, Kay EW, Murray FE. Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. J Gastroenterol Hepatol. 2007;22(10):1633-7.

Chung, Dr. Henry V Henry V. Chung, Mark Riley, Jin Kee Ho, Ben Lee, Eric Yoshida. Canadian Journal of Gastroenterology "Retrospective review of the pediatric and adult autoimmune hepatitis in two quaternary care centres in British Columbia: increased prevalence seen in BC's First Nations communities". (accepted for publication).

Enns, Dr. Robert A Lee JK, Enns R. Review of idiopathic pancreatitis. World J Gastroenterol 2007; 13: 6296-313. Cohen RD, Bowie WR., Enns R, Flint J, Fitzgerald JM. Pulmonary actinomycosis complicating infliximab therapy for Crohn's disease. Thorax 2007; 62: 1013-14. Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Colombel JF, Panccione R, D'Haens G, Li J, Rosenfeld MR, Kent JD, Pollack PF. Adlimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med 2007; 146: 829-38. Enns R. Transit times in capsule endoscopy: are all patients the same? Dig Liver Dis 2007; 39:10:581-83. Romagnuolo J, Barkun AN, Enns R, Armstrong D, Gregor J. Simple clinical predictors may obviate urgent endosocopy in selected patients with nonvariceal upper gastrointestinal tract bleeding. Arch Intern Med 2007; 167: 265-70. Law JK, Amar JN, Kirby SD, Zetler PJ, Enns RA. Colonic Cryptococcus infection. Gastrointest Endosc 2007; 65: 525-56. Lee J, Enns R. Endoscopic mucosal resection in the setting of Barrett's esophagus. Can J Gastro 2007; 21(3):151-155. Todd Witte, R Enns. The difficult colonoscopy. Can J Gastro 2007;21:487-90 R Enns Capsule endoscopy: In search of the ideal image. Editorial Am J Gastro 2007:102-1-3. N Mahmoudi, R Enns, E Lam, J Amar J Telford. Biliary Brush Cytology: Factors associated with a positive outcome. World Journal of Gastroenterology 2007;Dec 28;13(48); 569-73. Armstrong D, Enns R, Ponich T, Romagnuolo J, Springer J and Barkun A. Credentialing guidelines for endoscopic privileges. Can J Gastro 2007;21(12)797-01. Enns R. Quality indicators in colonoscopy. Can J Gastroenterol 2007;21:277-9. Armstrong D, Enns R, Ponich T, Romagnuolo J, Springer J and Barkun A. Credentialing guidelines for endoscopic privileges. Can J Gastro 2007;21(12)797-01. Colombel JF, Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R, Schreiber S, Byczkowski D, Li J, Kent JD, Pollack PF. Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: Results of the CHARM Trial. Gastroenterology. 2007;132:52-65.

UBC Department of Medicine Page 207 Annual Report 2007

Salh, Dr. Baljinder Singh Wang SW, Parhar K, Chiu KJ, Tran A, Gangoiti P, Kong J, Gonzalez M, Salh B, Duronio V, Steinbrecher UP, Gomez-Munoz A. Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway. Cell Signal 19: 1772-83, 2007. Salh B. C-Jun N-Terminal Kinases as Potential Therapeutic Targets. Expert Opin Ther Targets 11: 1339-53, 2007. Intaraprasong P, Assi K, Owen D, Huntsman D, Chung S, Scudamore C, Yoshida E, Salh B. Expression of Integrin-linked kinase is not a useful prognostic marker in resected hepatocellular cancer. Anticancer Res 27: 4371-6, 2007. K Parhar, J Morse and B Salh. The Role of CK2 in Epithelial Cell Inflammatory Signaling Int J of Colorectal Dis 22:601-9, 2007, Epub Sep 29 2006. K Parhar, S Eivemark, A Gómez-Muñoz, A Yee and B Salh Investigation of Interleukin 1? -Mediated Regulation Of NF-?B In Colonic Cells Reveals Divergence Between PKB And PDK -Transduced Events. Mol Cell Biochem 300:113-27, 2007, Epub Nov 2006.

Steinbrecher, Dr. Urs P Wang SW, Parhar K, Chiu KJ, Tran A, Gangoiti P, Kong J, Gonzalez M, Salh B, DuronioV, Steinbrecher UP, and Gómez-Muñoz A. Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway. 2007. Cell. Signal. 19:1772-1783. Kim PTW, Davis JE, Erb SR, Yoshida EM, Steinbrecher UP. Colonic malakoplakia in a liver transplant recipient. 2007 Can. J. Gastroent. 21:753-755.

Tai, Dr. Isabella T Tang MJ and Tai IT. Reversal of chemotherapy resistance can be mediated through SPARC and its interaction and subsequent activation of caspase 8. J. Biol Chem., 2007 Sep 26; [Epub ahead of print] Taghizadeh F, MJ Tang, Tai, IT. Synergism between vitamin D and SPARC-induced apoptosis and inhibition of cell growth results in increased susceptibility of therapy-resistant colon cancer cells to chemotherapy. Mol. Cancer Ther., 2007 Jan;6(1):309-17

Yoshida, Dr. Eric M Buczkowski AK, Schaeffer DF, AlKattan, Ho JK, Yoshida EM, Steinbrecher UP, Erb S, Chung SW, Scudamore CH. Spatulated End-to-End Bile Duct Reconstruction in Liver Transplantation Reduces Biliary Complications and Further Procedures. Clinical Transplantation 2007; 21: 7-12. Koleba T, Yoshida EM, Partovi N. North American and European Health Care Workers Traveling to Countries Highly Endemic for Hepatitis A: Information and Recommendations. Internet Journal of Gastroenterology 2007; 5 (E-journal @ www.ispub.com). Santos AD, Partovi N, Ford JE, Yoshida EM. A Review of Anemia and Neutropenia in the Treatment of Chronic Hepatitis C with PegInteferon & Ribavirin Combination Therapy and the Use of Hematologic Growth Factors as Adjuvant Therapy. Annals of Pharmacotherapy 2007; 41: 268-75. Peter T.W. Kim, Jenny E. Davis, Siegfried R. Erb, Eric M. Yoshida, Urs P. Steinbrecher. Colonic Malakoplakia in a Liver Transplant Recipient. Canadian Journal of Gastroenterology 2007; 21: 753-55. Henry V. Chung, Mark Riley, Jin Kee Ho, Benjamin Leung, Gareth P. Jevon, Laura Arbour, Richard Schreiber, Eric M. Yoshida. Retrospective Review of Pediatric and Adult Autoimmune Hepatitis in Two Quaternary Care Centres in British Columbia: Increased Prevalence Seen in BC’s First Nations Communities. Canadian Journal of Gastroenterology 2007; 21: 565-58. Jin Kee Ho, Nasim Mahmoudi, Jaber Alali, Eric M. Yoshida, Michael F. Byrne. Duodenal Varices: A Rare Manifestation of Portal Hypertension. Internet Journal of Gastroenterology 2007; 5 (E-journal @ www.ispub.com).

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Fasial Saleh, Hin Hin Ko, Jenny Davis, Wichian Apiratpracha, James J. Powell, Eric M. Yoshida. Fatal Hepatitis C after Cyclophosphamide and Corticosteroid Treatment Therapy. Annals of Hepatology 2007; 6: 186-89 Hin Hin Ko, Eric M. Yoshida. Salud i. Ciencia. La Fibrosis Hepatica Puede Revertirse Con El Tratamiento Adecuado (Regression of Cirrhosis). April 30, 2007 (www.siicsalud.com) (Invited Article subjected to peer-review process; translated into Spanish by journal Editors). Pongphob Intaraprasong, Kirin Assi, David A. Owen, David G. Huntsman, Stephen W. Chung, Charles H. Scudamore, Eric M. Yoshida, Baljinder Salh. Expression of Integrin-linked Kinase is not a Useful Prognostic Marker in Resected Hepatocellular Cancer Anti-Cancer Research 2007; 27: 4371-76.

GENERAL INTERNAL MEDICINE

Birmingham, Dr. Carl Laird Birmingham CL, Cardew S, Gritzner S. Gastric bezoar in anorexia nervosa. The Journal of Eating and Weight Disorders. 12(2):e28-9 (2007). Birmingham CL, Gritzner S. Heart failure in anorexia nervosa: case report and review of the literature. The Journal of Eating and Weight Disorders. 12(1):e7-10. (2007). Birmingham CL, Sidhu FK.Complementary and alternative medical treatments for anorexia nervosa: case report and review of the literature. Eat Weight Disord. 12(3):e51-3. (2007). Lear SA, Humphries KH, Kohli S, Birmingham CL.The Use of BMI and Waist Circumference as Surrogates of Body Fat Differs by Ethnicity. Obesity (Silver Spring). 15(11):2817-24. (2007). Lear SA, Humphries KH, Kohli S, Frohlich JJ, Birmingham CL, Mancini GB. Visceral Adipose Tissue, a Potential Risk Factor for Carotid Atherosclerosis. Results of the Multicultural Community Health Assessment Trial (M-CHAT). Stroke. 38(9):2422-9 (2007). Procyshyn RM, Wasan KM, Thornton AE, Barr AM, Chen EY, Pomarol-Clotet E, Stip E, Williams R, Macewan GW, Birmingham CL, Honer WG; for the Clozapine and Risperidone Enhancement Study Group. Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment.J Psychiatry Neurosci. 32(5):331-338. (2007). Lear SA, Humphries KH, Frohlich JJ, Birmingham CL. Appropriateness of current thresholds for obesity-related measures among Aboriginal people. CMAJ. 177(12):1499-505. (2007). Lear SA, Humphries KH, Kohli S, Chockalingam A, Frohlich JJ, Birmingham CL. Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT).Am J Clin Nutr. 86(2):353-9 (2007).

Hatala, Dr Rose Hatala R, Cole G, Kassen BO, Bacchus M, Issenberg SB. Does physical examination competence correlate with bedside diagnostic acumen? An observational study. Med Teach. 2007; 29:199-203. Hatala R, Issenberg SB, Kassen BO, Cole G, Bacchus CM, Scalese RJ. Assessing the relationship between cardiac physical examination technique and accurate bedside diagnosis during an OSCE. Acad Med. 2007; 82 (10 supplement): S26-9. Eva KW, Hatala R, LeBlanc VR, Brooks LR. Teaching from the clinical reasoning literature: suggesting combined reasoning strategies helps novice diagnosticians overcome misleading information. Med Ed. 2007; 41(12):1152-58.

Hawley, Dr. Philippa H Fast Fact and Concept (invited review): Non-tricyclic antidepressants for neuropathic pain, published in the Journal of Palliative Medicine Sept 2007.

Kennedy, Dr. James R Kuzak N, Brubacher JR, Kennedy JR. "Reversal of salicylate-induced euglycemic delirium with dextrose". Clinical Toxicology 2007;45:526-529. UBC Department of Medicine Page 209 Annual Report 2007

Brodkin E, Copes R, Mattman A, Kennedy J, Kling R, Yassi A. "Lead and Mercury exposures: interpretation and action". CMAJ 2007; 176(1):59-63.

Khan, Dr. Nadia A Wardman D, Quantz D, Tootoosis J, Khan N. Tobacco cessation drug therapy among Canada's Aboriginal people. Nicotine Tob Res. 2007 May;9(5):607-11. Ma, I, N. Khan, A Kang, N Zalunardo, A Palepu. Reporting of Race/Ethnicity and Socioeconomic Factors in General Medical Journals. J Clin Epidemiol. 2007 Jun;60(6):572-8. Epub 2007 Mar 26 Khan NA, McAlister FA. Beta-blockers for the treatment of hypertension: a re-examination of published data. CMAJ. 2007 Feb (letter to the Editor). Khan N, McAlister FA.Rebuttal: Do beta-blockers have a role in treating hypertension? Yes. Can Fam Physician. 2007 May;53(5):800-3. PMID: 17872734. Khan N, McAlister FA. Do beta-blockers have a role in treating hypertension? Yes. Can Fam Physician. 2007 Apr;53(4):614-21. PMID: 17872702. Khan NA, Hemmelgarn B, Padwal R, Larochelle P, Mahon JL, Lewanczuk RZ, McAlister FA, Rabkin SW, Hill MD, Feldman RD, Schiffrin EL, Campbell NR, Logan AG, Arnold M, Moe G, Campbell TS, Milot A, Stone JA, Jones C, Leiter LA, Ogilvie RI, Herman RJ, Hamet P, Fodor G, Carruthers G, Culleton B, Burns KD, Ruzicka M, deChamplain J, Pylypchuk G, Gledhill N, Petrella R, Boulanger JM, Trudeau L, Hegele RA, Woo V, McFarlane P, Touyz RM, Tobe SW; Canadian Hypertension Education Program.The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 2 - therapy. Can J Cardiol. 2007 May 15;23(7):539-50. PMID: 17534460. Padwal RS, Hemmelgarn BR, McAlister FA, McKay DW, Grover S, Wilson T, Penner B, Burgess E, Bolli P, Hill M, Mahon J, Myers MG, Abbott C, Schiffrin EL, Honos G, Mann K, Tremblay G, Milot A, Cloutier L, Chockalingam A, Khan NA, Rabkin SW, Dawes M, Touyz RM, Tobe SW; Canadian Hypertension Education Program. The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol. 2007 May 15;23(7):529-38. PMID: 17534459. Ma IW, Khan NA, Kang A, Zalunardo N, Palepu A. Systematic review identified suboptimal reporting and use of race/ethnicity in general medical journals. J Clin Epidemiol. 2007 Jun;60(6):572-8. Epub 2007 Mar 26. PMID: 17493512. Wardman D, Quantz D, Tootoosis J, Khan N.Tobacco cessation drug therapy among Canada's Aboriginal people. Nicotine Tob Res. 2007 May;9(5):607-11. PMID: 17454717. Hemmelgarn BR, Chou S, Wiebe N, Culleton BF, Manns BJ, Klarenbach S, Khan NA, Gourishankar S, Yeates KE, Gill JS, Tonelli M. Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian, and white ESRD patients in Canada. Am J Kidney Dis. 2006 Dec;48(6):964-71. Erratum in: Am J Kidney Dis. 2007 Feb;49(2):348. PMID: 17162151.

Magee, Dr. Laura A von Dadelszen P, Menzies J, Gilgoff S, Xie F, Douglas MJ, Sawchuck D, Magee LA. Evidence-based management for preeclampsia. Frontiers in Bioscience 2007;12:2876-89. Newstead J, von Dadelszen P, Magee LA. Pre-eclampsia and future cardiovascular risk. Expert Review of Cardiovascular Therapy 2007;5(2):283-94 (MSFHR). Menzies J, Magee LA, MacNab Y, Li J, Yin R, Stuart H, Baraty B, Lam E, Hamilton T, Lee SK, von Dadelszen P for the PIERS Study Group. Instituting guidelines is associated with a reduced incidence of adverse outcomes in women with pre-eclampsia: a single site study. Obstet Gynecol 2007;110:121-7 (CIHR, CFRI, MSFHR). Menzies J, Magee LA, MacNab YC, Ansermino JM, Li J, Douglas MJ, Gruslin A, Kyle P, Lee SK, Moore MP, Moutquin JM, Smith GN, Walker JJ, Walley KR, Russell JA, von Dadelszen P. Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes. Hypertens Pregn 2007;26:447-62 (CIHR, CFRI, MSFHR).

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Magee LA, von Dadelszen P, Chan S, Gafni A, Gruslin A, Helewa M, Hewson S, Kavuma E, Lee SK, Logan AG, McKay D, Moutquin J-M, Ohlsson A, Rey E, Ross S, Singer J, Willan AR, Hannah ME, for the CHIPS Pilot Trial Collaborative Group. The CHIPS (Control of Hypertension In Pregnancy Study) Pilot Trial. BJOG 2007;114(6):770, e13-20 (CIHR, CFRI, MSFHR). Magee LA and von Dadelszen P. Pre-eclampsia and risk revealed. BMJ 2007;335(7627):945-6. Magee LA, von Dadelszen P, Chan S, Gafni A, Gruslin A, Helewa M, Hewson S, Kavuma E, Lee SK, Logan AG, McKay D, Moutquin J-M, Ohlsson A, Rey E, Ross S, Singer J, Willan AR, Hannah ME, for the CHIPS Pilot Trial Collaborative Group. Women’s views of their experiences in the CHIPS (Control of Hypertension In Pregnancy Study) Pilot Trial. Hypertens Pregn 2007;26:371-87 (CIHR, CFRI, MSFHR).

Ma, Dr. Irene W

Zalunardo NY, Rose CL, Ma IW, Altmann P. Higher serum C-reactive protein predicts short and long-term outcomes in peritoneal dialysis-associated peritonitis. Kidney Int. 2007 Feb 14; [Epub ahead of print] PMID: 17299522 . Ma IW, Khan NA, Kang A, Zalunardo N, Palepu A. Systematic review identified suboptimal reporting and use of race/ethnicity in general medical journals. J Clin Epidemiol. 2007 Jun;60(6):572-8. Epub 2007 Mar 26.

Ong-Lam, Dr. May C Peng, P.; Choiniere,M.; Dion,D.; Intrater,H.; Lefort,S.; Lynch,M.; Ong,M.; Rashiq,S.; Tkachuk,G.; Veillette, Y.: STOPPAIN Investigations Group. Challenges in accessing multidisciplinary pain treatment facilities in Canada (CAN J ANESTH 2007/54 12 / pages 977-984). Peng, P.; Stinson,JN.; Choiniere,M.; Dion,D.; Intrater,H.; Lefort,S.; Lynch,M.; Ong,M.; Rashiq,S.; Tkachuk,G.; Veillette, Y.: STOPPAIN Investigators Group. Dedicated multidisciplinary pain management centers for children in Canada: the current status (CAN J ANESTH 2007/54 12 / pages 985-991.

Palepu, Dr. Anita Ma IWY, Khan NA, Kang A, Zalunardo N, Palepu A. Reporting and Use of Race/Ethnicity in General Medical Journals. Journal of Clinical Epidemiology 2007; 60 (6): 572-80. Kim TW, Palepu A, Cheng DM, Libman H, Saitz R, Samet JH. Factors associated with discontinuation of antiretroviral therapy in HIV-infected patients with alcohol problems. AIDS Care, Feb 2007; 19(8): 1039-47. Ogilvie GS, Palepu A, Maan E, Remple V, Heath K, MacDonald G, Christilaw J, Berkowitz J, Fisher WA, Brudge D. Fertility intentions of of reproductive age living with HIV in British Columbia, Canada. AIDS. 2007;21 Suppl 1:S83-8. Wood E, Hogg RS, Kerr T, Bonner S, Strathdee SA, Palepu A, Montaner JS. Rates of inappropriate antiretroviral prescription among injection drug users. Harm Reduction Journal 2007; 4: 2. Carr PL, Palepu A*, Szalacha L, Caswell C, Inui T. Flying below the radar: A qualitative study of minority experience and management of discrimination in academic medicine. Medical Education 2007; 41: 601-9. Hubley AM, Palepu A. Injection Drug Use Quality of Life Scale (IDUQOL): Findings from a Content Validation Study. Health Qual Life Outcomes. 2007; 5 (1): 46. Willinsky J, Murray S, Kendall C, Palepu A. Doing medical journals differently: Open medicine, open access and academic freedom. Canadian Journal of Communications, Special issue Health Communications. 2007; 32:595-612.

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GERIATRIC MEDICINE

Adler, Dr. Reva N Adler RN. A Calamity in the Neighbourhood: Women's Participation in the Rwandan Genocide. Genocide Studies and Prevention, 2(3):209-233. Nov 2007.

Beattie, Dr. Beverley L O’Connor, D, A Phinney, A Smith, J Small, B Purves, J Perry, E Drance, M Donnelly, H Chaudhury, L Beattie, "Personhood in dementia care: Developing a research agenda for broadening the vision", Dementia 2007; 6; 121. Beattie, BL. Consent in Alzheimer's disease research; risk/benefit factors. Can J Neurol Sci (2007) 34: Suppl.1 S27-31 . Fisk JD, Beattie BL, Donnelly M, Byszewski A, Molnar FJ. Disclosure of the diagnosis of dementia. Alzheimer's & Dementia 3 (2007) 404-410. Fisk JD, Beattie BL, Donnelly M. Ethical considerations for decision making for treatment and research participation. Alzheimer's & Dementia 3 (2007) 411-417.

Cook, Dr. Wendy L Jassal SV, Maitry M, Sekercioglu N, Baloch S, Cook WL. Causes of Death in Older Peritoneal Dialysis patients - can we depend on registry reports? International Urology and Nephrology. 2007; Epub 2007 Mar 1. Donaldson MG, Sobolev B, Kuramoto L, Cook WL, Khan KM, Janssen PA. Utility of the Mean Cumulative Function in the analysis of recurrent falls. J Gerontology Biol & Med Sci. 2007; Apr;62(4):415-9.

Hill, Dr. Amanda Thornton, Wendy, Shapiro, JR, Deria, S, Gelg, S, Hill AJ. "Differential impact of age on verbal memory and executive functioning in chronic kidney disease." J International Neuropsychological Society (2007), 13, 344-353.

Lee, Dr. Philip E Gill SS, Bronskill SE, Normand S-LT, Anderson GM, Sykora K, Lam K, Bell CM, Lee PE, Fischer HD, Hermann N, Gurwitz JH, Rochon PA. Antipsychotic Drug Use and Mortality in Older Adults with Dementia. Ann Int Med 2007; 146: 775-786.

Madden, Dr. Kenneth M Kenneth M. Madden, Gale Tedder, Chris Lockhart. The Oral Glucose Tolerance Test Induces Myocardial Ischemia in Healthy Older Adults. Clinical Investigative Medicine 30 (3): E118-E126, 2007.

Meneilly, Dr. Graydon S Mackelvie KJ, Meneilly GS, Elahi D, Wong ACK, Barr SI, Chanoine J-P. Regulation of Appetite in Lean and Obese Adolescents Following Exercise: Role of Acylated and Deacylated ghrelin. J. Clin Endodrinol Metab. 92: 648-654, 2007. Khalil N, Fung M, Shapiro RJ, Warnock GL, Elahi D, Meneilly GS, Thompson D. Effect of Exenatide on Beta Cell Function After Islet Transplantation in Type 1 Diabetes. Transplantation. 83: 24-38, 2007. Meneilly GS. A comparison of Insulin aspart and regular insulin in elderly patients with type 2 diabetes. Diabetes, Obesity and Metabolism. 9: 754-755, 2007. Fung MA, Warnock GL, Ao Z, Keown P, Meloch M, Shapiro RJ, Ho S, Worsley D. Meneilly GS, Al Ghofali K, Kozak SE, Tong SO, Trinh M, Blackburn L, Kozak RM, Fensom BA, Thompson DM. The

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effect of medical therapy and islet cell transplantation on diabetic nephropathy: an interim report. Transplantation 84(1): 17-22. 2007. Kassam R, Meneilly GS. Role of the pharmacist on a multi-disciplinary diabetes team. Canadian Journal of Diabetes. 31(3): 215-222, 2007.

Wong, Dr. Roger Y Villanyi D, Wong RYM. Self-reported understanding of diabetes and its treatment among elderly ambulatory subjects in British Columbia. Am J Geriatr Pharmacother 2007; 5: 18-30 (Senior Author, Supervised Dr. D Villanyi). Wong RY, Kassen BO, Hollohan K, Hatala R, Roberts JM. A new interactive forum to promote awareness and skills in quality improvement among internal medicine residents: a descriptive report. Can J Gen Int Med 2007; 2 (1): 35-6 (Principal Author). Nguyen VC, Miller WC, Asano M, Wong RY. Measurement properties of the L test for gait in hospitalized elderly. Am J Phys Med Rehabil 2007; 86(6): 463-8 (Co-Senior Author with Dr. WC Miller, Supervised Dr. VC Nguyen). Wilbur K, Wong RY. Assessing geriatric patients’ ability to functionally manage medication packaging. Can J Hosp Pharm 2007; 60(4): 238-44 (Co-Senior Author with Dr. K Wilbur) Wong RY, Roberts JM. Real time curriculum map for internal medicine residency. BMC Medical Education 2007; 7: 42 (Principal Author).

HEMATOLOGY

Barnett, Dr. Michael J Gallagher G, Channabhai M, Song KW, Barnett MJ. Unusual presentation of precursor T-cell lymphoblastic lymphoma: involvement limited to breasts and skin. Leuk Lymphoma 48(2): 428-430, 2007. Dalal BI, Bruyere H, Barnett MJ. Significance of persistent Auer rods and cytogenetic abnormality after first cycle of therapy for acute promyelocytic leukaemia. British Journal of Haematology 137, 385, 2007. Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC. Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007. Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007.

Benny, Dr. W. B Sampath S, Meneghetti AT, MacFarlane JK, Nguyen NH, Benny WB, Panton ON. An 18-year review of open and laparoscopic splenectomy for idiopathic thrombocytopenic purpura. Am J Surg 193(5): 580-3, 2007.

Eaves, Dr. Connie Khattra J, Delaney AD, Zhao Y, Siddiqui A, Asano J, McDonald H, Pandoh P, Dhalla N, Prabhu AL, Ma K, Lee S, Ally A, Tam A, Sa D, Rogers S, Charest D, Stott J, Zuyderduyn S, Varhol R, Eaves C,

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Jones S, Holt R, Hirst M, Hoodless PA & Marra M. Large scale production of SAGE libraries from microdissected tissues, flow-sorted cells and cell lines. Genome Res 17: 108-116, 2007.

Forrest, Dr. Donna L Dalal BI, Horsman DE, Bruyere H, and Forrest DL. Imatinib Mesylate Responsiveness in Aggressive Systemic Mastocytosis: Novel Association with a Platelet Derived Growth Factor Receptor Beta Mutation. Am J Hematol 82(1): 77-9, 2007. Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC. Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007. Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007. Gallagher G, Forrest DL. Second solid cancers after allogeneic hematopoietic stem cell transplantation. Cancer 109(1): 84-92, 2007.

Hogge, Dr. Donna Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. JC Ann Oncol 18(7): 1246-52, 2007 Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007.

Lansdorp, Dr. Peter M Xin ZT, Beauchamp A, Calado RT, Bradford JW, Regal JA, Shenoy A, Liang Y, Lansdorp PM, Young NS & Ly H. Functional characterization of natural telomerase mutations found in patients hematological disorders. Blood 109: 524-532, 2007. Baerlocher GM, Rice K, Vulto I & Lansdorp PM. Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around one year of age. Aging Cell 6: 121-123, 2007. Alter BP, Baerlocher GM, Savage SA, Chanock SJ, Weksler BB, Willner JP, Peters JA, Giri N & Lansdorp PM. Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood 110: 1439-1447, 2007. Baerlocher GM, Sloand EM, Young NS & Lansdorp PM. Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size. Exp Hematol Epub ahead of print 2007. Calado RT, Graf SA, Wilkerson KL, Kajigaya S, Ancliff PJ, Dror Y, Chanock SJ, Lansdorp PM & Young NS. Mutations in the SBDS gene in acquired aplastic anemia. Blood 110: 1141-1146, 2007. Lansdorp PM. Immortal strands? Give me a break. Cell 129: 1244-1247, 2007.

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Ouyang Q, Baerlocher G, Vulto I & Lansdorp PM. Telomere length in human natural killer cell subsets. Ann N Y Acad Sci 1106: 240-252, 2007. Shepherd BE, Kiem H-P, Lansdorp PM, Dunbar CE, Aubert G, Larochelle A, Seggewiss R, Guttorp P & Abkowitz JL. Hematopoietic stem cell behavior in non-human primates. Blood 110: 1806-1813, 2007. Westin ER, Chavez E, Lee KM, Gourronc FA, Riley S, Lansdorp PM, Goldman FD & Klingelhutz AJ. Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. Aging Cell 6: 383-394, 2007. Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, Brosh RM, Jr. & Blackshear PJ. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol 27: 1784-1794, 2007. Röth A, Dürig J, Himmelreich H, Bug S, Siebert R, Dührsen U, Lansdorp PM & Baerlocher GM. Short telomeres and high telomerase activity in T-cell prolymphocytic leukemia (T-PLL). Leukemia Epub ahead of print 2007. Armanios MY, Chen JJ-L, Cogan JD, Alder JK, Ingersoll RG, Xie M, Markin C, Lawson WE, Vulto I, Phillips III JA, Lansdorp PM, Greider CW & Loyd JE. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med 356: 1317-1326, 2007.

Lavoie, Dr. Julye C Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC. Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007. Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007.

Leger, Dr. Chantal S Leitch HA, Leger, CS, Wong KK, Goodman TA, Galbraith PF, Vickars LM. . "Improved Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy". New Evidence; Canadian Vision of Oncology 6; 32-34, 2007. Ezzat H, Filipenko D, Vickars L, Galbraith P, Li C, Murphy K, Montaner J, Harris M, Hogg R, Vercauteren S, Leger CS, Zypchen L, Leitch HA. "Improved survival in HIV-Associated B-cell non-Hodgkin's lymphoma with the addition of rituximab to chemotherapy in patients receiving Highly Active Anti-Retroviral Therapy." HIV Clinical Trials 8(3):132-44, 2007. Fung SS, Hillier KL, Leger CS, Vickars LM, Galbraith PF, Li CH, Leitch HA. "Clinical Progression and Outcome of Patients with Monoclonal B-Cell Lymphocytosis", Leukemia & Lymphoma 48(6):1087-91, 2007.

Leitch, Dr. Heather A Garcia-Manero G. Improved Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy, "Advances in the Treatment of MDS", Clinical Advances in Hematology & Oncology 5(3Suppl6): 11-12, 2007.

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Leitch HA, Leger, CS, Wong KK, Goodman TA, Galbraith PF, Vickars LM. . "Improved Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy". New Evidence; Canadian Vision of Oncology 6; 32-34, 2007. Meeting Highlights from the 48th Annual Meeting of the American Society of Hematology. Iron chelation therapy improves survival in MDS. Community Oncology 4(3): 108-109, 2007 Ezzat H, Filipenko D, Vickars L, Galbraith P, Li C, Murphy K, Montaner J, Harris M, Hogg R, Vercauteren S, Leger CS, Zypchen L, Leitch HA. "Improved survival in HIV-Associated B-cell non-Hodgkin's lymphoma with the addition of rituximab to chemotherapy in patients receiving Highly Active Anti-Retroviral Therapy." HIV Clinical Trials 8(3):132-44, 2007. Fung SS, Hillier KL, Leger CS, Vickars LM, Galbraith PF, Li CH, Leitch HA. "Clinical Progression and Outcome of Patients with Monoclonal B-Cell Lymphocytosis", Leukemia & Lymphoma 48(6):1087-91, 2007. Cheung MC, Imrie KR, Leitch HA, Buckstein R, Antoniou T, Park-Wylie L, Loutfy MR. "Physician perceptions and preferences in the treatment of acquired immunodeficiency syndrome (AIDS)-related lymphoma". Annals of Hematology 86(9):631-8, 2007. Leitch HA. "Improving Clinical Outcomes in patients with Myelodysplastic Syndrome and Iron Overload Using Iron Chelation Therapy". Leukemia Research 31Suppl3:S7-9, 2007.

Li, Dr. Charles H Yenson PR, Yoshida EM, Li CH, Chung HV, Tsang PWK. Hyperferritinemia in the Chinese and Asian Community: A Retrospective Review of the University of British Columbia Experience. Can J Gastro (accepted for publication June 2007). Fung SS, Hillier KL, Leger CS, Sandhu I, Vickars LM, Galbraith PF, Li CH, Leitch HA. Clinical Progression and Outcome of Patients with Monoclonal B-Cell Lymphocytosis. Leuk Lymphoma (accepted for publication March 2007).

Nantel, Dr. Stephen H Anderson A, Ali K, Blanchette V, Brouwers M, Couban S, Radmoor P, Huebsch L, Hume H, McLeod A, Meyer R, Moltzan C, Nahirniak S, Nantel S, Pineo G, Rock G. Guidelines on the Use of Intravenous Immune Globulin for Hematologic Conditions. Transfusion Medicine Reviews Apr 2007 21:2 Suppl 1 ppS9-S56.

Nevill, Dr. Thomas J Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007 Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007.

Ramadan, Dr. Khaled M Khaled M Ramadan, Hakeem A Eswedi, Mawloud R El-Agnaf.Schnitzler's Syndrome: A Case Report of Successful Treatment Using the Anti-CD20 Monoclonal Antibody Rituximab. British Journal of Dermatology. Accepted.

UBC Department of Medicine Page 216 Annual Report 2007

Moulod R El-Agnaf, Cathy McCoy, Young-Lee Ong, Abdul-Hakeem Eswedi, Barbara Black, Khaled M Ramadan. Infusion of Rituximab Over 90-minutes on an Out-Patient Basis is Safe and Improves Resource Utilization. Leukemia and Lymphoma 48(9): 1875-77, 2007. Khaled M Ramadan, Hakeem A Eswedi, Mawloud R El-Agnaf. Schnitzler's Syndrome: A Case Report of Successful Treatment Using the Anti-CD20 Monoclonal Antibody Rituximab. Brit Jour of Dermatology 156: 1072-74, 2007. Ramadan K, Shenkier T, Sehn L, Gascoyne R, Connors JM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Annals of Oncology 18(1): 129-35, 2007.

Shepherd, Dr. John D Song K, Barnett M, Gascoyne R, Chhanabhai M, Forrest D, Hogge D, Lavoie J, Nantel S, Nevill T, Shepherd J, Smith C, Toze C, Voss N, Connors J. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic step-cell transplantation results in favorable outcomes. Ann Oncol 18: 535-540, 2007. Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007.

Smith, Dr. Clayton A Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007 Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007. Jiang X, Zhao Y, Smith CA, Gasparetto M, Saw AM, Eaves A, Eaves C. Chronic myeloid leukemia stem cells possess unique properties that predict intrinsic and acquired resistance to imatinib mesylate Leukemia (Epub Mar 1, 2007). Le Meur N, Rossini A, Gasparetto M, Smith C, Brinkman R, Gentleman R. Data quality assessment in high throughput flow cytometry experiments Cytometry (Epub Mar 15, 2007). Brinkman R, Gasparetto M, Lee J, Smith C. High content flow cytometry to determine predictors of GvHD following allogeneic transplantation. Biol of Blood and Marrow Transplantation (Epub Apr 6, 2007). Jiang X, Smith C, Eaves A, Eaves C. The challenges of targeting chronic myeloid leukemia stem cells Clilnical Lymphoma and Myeloma 7 suppl2: S71-80, 2007. Elevated aldehyde dehydrogenase activity is a general property of human hematopoietic stem cells that enables their improved purification. Hematologica, Epub Aug 1, 2007.

UBC Department of Medicine Page 217 Annual Report 2007

Song, Dr. Kevin W Gallagher G, Channabhai M, Song KW, Barnett MJ. Unusual presentation of precursor T-cell lymphoblastic lymphoma: involvement limited to breasts and skin. Leuk Lymphoma 48(2): 428-430, 2007. Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC. Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007. Gallagher G, Chhanabhai M, Song KW, Barnett MJ. Unusual presentation of precursor T-cell lymphoblastic lymphoma: involvement limited to breasts and skin. Leuk Lymphoma 48(2): 428-30, 2007. Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007.

Sutherland, Dr. Heather J Vercauteren SM, Zapf R, Sutherland HJ. Primitive AML progenitors from most CD34+ patients lack CD33 expression but progenitors from many CD34- AML patients express CD33. ISCT Cytotherapy 9(2): 194-204, 2007. Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007. Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC .Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007. Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007. Vercauteren Z, Zapf R, Sutherland H. Primitive AML progenitors from most CD34(+) patients lack CD33 expression but progenitors from many CD34(-) AML patients express CD33. Cytotherapy 9(2): 194-204, 2007. Randomized Phase III Study of Pegylated Liposomal Doxorubicin Plus Bortezomib Compared with Bortezomib Alone in Relapsed or Refractory Multiple Myeloma: Combination Thearpy Improves Time to Progression. J Clin Oncol 25:3892-3901, 2007.

Toze, Dr. Cynthia L Kuruvilla J, Shepherd JD, Sutherland HJ, Nevill TJ, Nitta J, Le A, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Toze CL, Smith CA, Barnett MJ, Song KW. Long-term outcome of myeloablative allogeneic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 13(8): 925- 31, 2007.

UBC Department of Medicine Page 218 Annual Report 2007

Halim TY, Song KW, Barnett MJ, Forrest DL, Hogge DE, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC Positive impact of selective outpatient management of high-risk acute myelogenous leukemia on the incidence of septicemia. Ann Oncol 18(7): 1246-52, 2007. Song KW, Barnett MJ, Gascoyne RD, Chhanabhai M, Forrest DL, Hogge DE, Lavoie JC, Nantel SH, Nevill TJ, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Voss NJ, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 18(3): 535-40, 2007.

Vickars, Dr. Linda M Shustik C, Belch A, Robinson S, Rubin SH, Dolan SP, Kovacs MJ, Grewal KS, Walde D, Barr R, Wilson J, Gill K, Vickars L, Rudinskas L, Sicheri DA, Wilson K, Djurfeldt M, Shepherd LE, Ding K, Meyer RM. A randomised comparison of melphalan with prednisone or dexamethasone as induction therapy and dexamethasone or observation as maintenance therapy in multiple myeloma: NCIC CTG MY.7. Br J Haematol 136(2): 203-11, 2007. Ezzat H, Filipenko D, Vickars L, Galbraith P, Li C, Murphy K, Montaner JS, Harris M, Hogg RS, Vercauteren S, Leger CS, Zypchen L, Leitch HA Improved survival in HIV-associated diffuse large B-cell lymphoma with the addition of rituximab to chemotherapy in patients receiving highly active antiretroviral therapy. HIV Clin Trials 8(3): 132-44, 2007. Fung SS, Hillier KL, Leger CS, Sandhu I, Vickars LM, Galbraith PF, Li CH, Leitch HA. Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis. Leuk Lymphoma 48(6): 1087-91, 2007.

Zypchen, Dr. Leslie N Improved survival in HIV-associated diffuse large B-cell lymphoma with the addition of rituximab to chemotherapy in patients receiving highly active antiretroviral therapy. HIV Clin Trials 8(3): 132-44, 2007. Ezzat H, Filipenko D, Vickars L, Galbraith P, Li C, Murphy K, Montaner JS, Harris M, Hogg RS, Vercauteren S, Leger CS, Zypchen L, Leitch HA. Improved survival in HIV-associated diffuse large B-cell lymphoma with the addition of rituximab to chemotherapy in patients receiving highly active antiretroviral therapy. HIV Clin Trials 8(3): 132-44, 2007.

INFECTIOUS DISEASES

Av-Gay, Dr. Yossef Y Mamta Rawat and and Yossef Av-Gay. (2007). Mycothiol dependent Proteins in Actinomycetes. FEMS Microbiology Reviews. 31:278-292. Zheng, X., Papavinasasundaram, K.G., and Av-Gay, Y. (2007), Novel Substrates of Mycobacterium tuberculosis PknH serine / Threonine Kinase. BBRC. 355:162-168. Deghmane AE, Soualhine H,Bach, H., Sendide K, Itoh S, Tam A, Noubir S, Talal A, Lo R, Toyoshima S, Av-Gay Y, Hmama Z. (2007). LpdC mediates retention of coronin-1 on M. bovis BCG vacuoles, leading to arrest in phagosome maturation. J. Cell Sci. 120(16):2796-2806. Miller,C. C. Rawat, M., Johnson, T., and Av-Gay, Y. (2007). Innate Protection of Mycobacteria Against the Antimicrobial Activity of Nitric Oxide is Provided by Mycothiol. Anti Microbial Agents and Chemotherapy, 51(9):3364-3366. Soualhine H, Deghmane AE, Mak K, Amina Talal A, Av-Gay Y, Hmama Z. (2007). Recombinant Mycobacterium bovis BCG secreting cathepsin S promotes MHC class II-directed antigen presentation by the macrophage cell line THP-1. J Immunol .179:5137-5145. Rawat, M., Johnson, T., Cadiz, V., and Av-Gay Y. (2007). Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis. BBRC. 363:71-76.

UBC Department of Medicine Page 219 Annual Report 2007

Bowie, Dr. William R Marra F, Monnet DL, Patrick DM, Chong M, Brandt CT, Winters M, Kaltoft MS, Tyrrell GJ, Lovgren M, Bowie WR. A comparison of antibiotic use in children between Canada and Denmark. Annals of Pharmacotherapy 2007; 41: 659-666. Cohen RD, Bowie WR, Enns R, FitzGerald JM. Pulmonary actinomycosis complicating infliximab therapy for Crohn's disease. Thorax 2007; 62: 1013-1014

Brunham, Dr. Robert C Brunham, R. C., N. Straka, R. White, C. Shen, C. Ma, T. Nayar, X. Jiang, J. Rey-Ladino, M. L. Zaharik and B. A. Vallance. "Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles". Immunology. 120.2 (2007): 160 - 172. Brunham, R. C., S. A. Tweed, M. Krajden, F. Marra, T. W. Tam, N. Bastien, S. W. Lee, M. Petric, S. T. David, D. M. Skowronski and Y. Li. "Protective measures and human antibody response during an avian influenza H7N3 outbreak in poultry in British Columbia, Canada". CMAJ Canadian Medical Association Journal. 176.1 (2007): 47 - 53. Mutwiri, G., D. J. Kelvin, C. Sharon, A. Cochrane, T. Auperin, C. Cameron, R. H. See, B. B. Finlay, M. Satkunarajah, J. M. Rini, S. Viswanathan, A. N. Zakhartchouk, M. Petric, L. A. Babiuk and R. C. Brunham. "Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: Implications for a subunit vaccine". Vaccine. 25.1 (2007): 136 - 143. Brunham, Robert, V P Remple, D M Patrick and P Kendall. "Needs, Gaps and Opportunities for Infectious Disease Research in British Columbia: A Perspective from Population and Public Health". Canadian Journal of Public Health-Revue Canadienne de Sante Publique.

Chow, Dr. Anthony W Hull MW, Chow AW: Indigenous microflora and innate immunity of the head and neck. Infect Dis Clin N Am 21:262-282, 2007. Reynolds SC, Chow AW: Life-threatening infections of the peripharyngeal and deep fascial spaces of the head and neck. Infect Dis Clin N Am 21:557-576, 2007.

Hmama, Dr. Zakaria Deghmane AE, Soualhine H, Sendide K, Itoh S, Tam A, Noubir S, Talal A, Lo R, Toyoshima S, Av- Gay Y, Hmama Z. Mycobacterial dihydrolipoamide dehydrogenase mediates retention of the coat protein coronin-1 on M. bovis BCG vacuoles leading to phagosome maturation arrest. J. Cell Sci. 120:2796-806, 2007. Sun J, Deghmane AE, Soualhine H, Hong T, Bucci C, Solodkin A, Hmama Z. Mycobacterium Bovis BCG inhibits Rab7-RILP interaction in the macrophage. J Leuk Biol., 82:1437-45, 2007. Soualhine H, Deghmane AE, Sun J, Mak K, Amina Talal A, Av-Gay Y, Hmama Z. Mycobacterium bovis BCG secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages. J Immunol, 179:5137-45, 2007.

Isaac-Renton, Dr. Judith McIntyre L., Pollock SL, Fyfe M, Gajadhar A, Isaac-Renton J, Fung J, Morshed, M. Trichinellosis from Game Meat Consumption in British Columbia. Can Med Assoc J. 176(4): 449-451, 2007. Morshed M, Lee M-K, Jorgensen D, and Isaac-Renton J. Molecular Methods Used in Clinical Laboratory: Prospects and Pitfalls. FEMS Immunology Med Microbiol. 49: 184-191, 2007. Isaac-Renton J, Ong C, Prystajecky N, Shay S, Edge T and Gannon V. Microbial Source Tracking: How Does it Help Public Health? CSEB Bulletin Limnology The Publicly Unknown Science of Inland Waters: Overview on Some of Its Important Topics 64(1): 8-12, 2007.

UBC Department of Medicine Page 220 Annual Report 2007

Ong C. Phung DC, Nguyen TT, Piche R, Hoang L, Fyfe M, Isaac-Renton J. (2007) A Canadian-Vietnamese collaboration on emerging parasitic diseases. CIDA/IDRC/CIHR/Health Canada Global Health Research Casebook. Matkovich H (ed.), pp. 16-18. Ogilvie G, Krajden M, Maginley J, Isaac-Renton J, Hislop G, Elwood-Martin R, Sherlock C, Taylor D, Rekart M. Can self collection for the Human Papillomavirus (HPV) improve access for cervical cancer screening in at-risk women in developed countries? Can Med Assoc J. 177(5) 480-483. Quan G, Gilbert M, David ST, McNabb A, Shaw C, Adie K, Rahim T, Isaac-Renton J, Patrick DM. Usefulness of Pulsed Field Gel Electrophoresis in Tracking Invasive Serogroup C. Meningococcal Disease. Can J Inf Dis Med Microbiol. 18(6): 363-367.

Money, Dr. Deborah M Gagnon S, Hankins C, Money D, Pourreaux K, The Canadian Women's HIV Study Group, Franco E, Coutlee F. Polymorphism of the L1 Capsid Gene and Persistence of Human Papillomavirus Type 52 Infection in Women at High Risk or Infected by HIV. Journal of Acquired Immune Deficiency Syndromes. January 2007;44(1):61-65. Money D, Provencher D. Epidemiology and Natural History of HPV Infection. Journal of Obstetrics and Gynaecology Canada. August 2007;29(8):S7-S10. Wilson RD, Johnson JA, Summers A, Wyatt P, Allen V, Gagnon A, Langlois S, Blight C, Money DM, Boucher M, Gruslin A, Mackinnon CJ, Paquet C, van Schalkwyk J, Cohen HR, Steben M, Wong T, Yudin MH. Principles of human teratology: drug, chemical, and infectious exposure. Journal of Obstetricians & Gynaecologists of Canada. November 2007;29(11):911-917. Steben M, Money D. Counselling. Journal of Obstetrics and Gynaecology Canada. August 2007;29(8):S55-S56. Coutlee F, Rouleau D, Ghattas G, Hankins C, Vezina S, Cote P, Macleod J, de Pokomandy A, Money, D, Walmsley S, Voyer H, Brassard P, Franco E. Real-time PCR assay to detect HPV-52 in anogenital specimens screened for HPV infection with the LINEAR ARRAY HPV Genotyping Test. Journal of Clinical Microbiology. November 2007;45(11):3821-3823. Ogilvie G, Remple V, Marra F, McNeill S, Naus M, Pielad K, Ehlen T, Dobson S, Money D, Patrick D. Parental intention to have daughters receive the human papillomavirus vaccine. Canadian Medical Association Journal. December 2007;177(12):1506-12.

Montessori, Dr. Valentina C Barraclough K, Harris M, Montessori V, Levin A. An unusual case of acute kidney injury due to vancomycin - lessons learnt from reliance or eGFR, Nephrol Dial Transplant 2007;1-4.

Moore, Dr. David M Moore D, Liechty C, Ekwaru P, Were W, Mwima G, Solberg P, Rutherford G, Mermin J. Prevalence, incidence and mortality associated with tuberculosis in HIV-infected individuals initiating antiretroviral therapy in rural Uganda. AIDS 2007 21(6):713-719. Lima V, Hogg RS, Harrigan PR, Moore D, Yip B, Wood E, Montaner JSG. Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy. AIDS 2007 21(6):685-692.

Nandan, Dr. Devki Moeenrezakhanlou, A., Nandan, D. and Reiner, N.E. (2007). 1, 25-Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol 3-kinase-dependent Manner. J. Leukocyte Biol. 81: 1311-21. Nandan, D., Lopez, M., Ban F., Huang M., Li, Y., Reiner NE and Cherkasov, A (2007). Indel-based targeting of essential proteins in human pathogens that have close host orthologue(s): Discovery of selective inhibitors for Leishmania donovani elongation factor-1alpha. Proteins. 67(1):53-64

UBC Department of Medicine Page 221 Annual Report 2007

Lopez, M, Thao, T., Tran .E., Silverman, J.E and D. Nandan (2007). Leishmania aldolase as a selective activator of macrophage Src homology 2 domain containing tyrosine phosphatase SHP-1. Biochem.Biophys. Res. Commun. 364: 601-607. Wei, Ma., Mishra, S., Gee. K., Mishra, J.P., Nandan, D., Reiner, N.E., Angel, J, and Kumar, A (2007). Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated PI3K in LPS-stimulated human monocytic Cells. J. Biol Chem. 282: 13351- 62. Lopez, M., Cherkasov, A and D. Nandan (2007). Molecular architecture of EF-1alpha from Leishmania donovani reveals a novel site involved in protein translation suitable for drug targeting. Biochem. Biophys. Res. Commun. 356: 886-892.

Patrick, Dr. David M Shoveller JA, Johnson JL, Prkachin K, Patrick DM. Around here, they roll up the streets at night: A qualitative study of youth living in a rural Canadian community. Health Place. 2007 13(4):826-38. [Epub ahead of print] CA. Marra F, Monnet DL, Patrick DM, Chong M, Brandt CT, Winters M, Kaltoft MS, Tyrrell GJ, Lovgren M, Bowie WR. A comparison of antibiotic use in children between Canada and Denmark Ann Pharmacother. 2007 41(4): 659-66 [Epub ahead of print], CA. Yassi A, Lockhart K, Copes R, Kerr M, Corbiere M, Bryce E, Danyluk Q, Keen D, Yu S, Kidd C, Fitzgerald M, Thiessen R, Gamage B, Patrick DM, Bigelow P, Saunders S; SARS Study Team Determinants of healthcare workers' compliance with infection control procedures. Healthc Q. 2007;10(1):44-52. MA. Ochnio JJ, Scheifele DW, Marion SA, Bigham M, Patrick DM, Ho M, Mozel M. Participant-ollected, mail-delivered oral fluid specimens can replace traditional serosurveys: a demonstration-of-feasibility survey of hepatitis A virus-specific antibodies in adults. Can J Public Health. 2007 Jan-Feb;98(1):37-40. CA. Bjornson G, Scheifele D, Bettinger J, Patrick DM, Gustafson L, Daly P, Tyrrell GJ. Effectiveness of pneumococcal conjugate vaccine in greater Vancouver, Canada. Pediatric Infectious Disease Journal 2007; 26(6): 540-542. CA. Remple VP, Johnston C, Patrick DM, Tyndall MW, Jolly A. Conducting HIV/AIDS research with indoor commercial sex workers: Reaching a hidden population. Progress in Community Health Partnerships: Research, Education, and Action 2007; 1(2): 161-8. CA. Remple VP, Patrick DM, Johnston C, Tyndall MW, Jolly AM. Clients of indoor commercial sex workers: heterogeneity in patronage patterns and implications for HIV and STI propagation through sexual networks. Sex Transm Dis. 2007; 34(10):754-60. CA MacDonald N, Weir E, Patrick DM, Potvin L, Scott J. Expansion of CMAJ's support for health promotion and disease prevention. Can. Med. Assoc. J., Jul 2007; 177: 268 - 269 CA. * Patrick DM. Prevention Strategies: Experience of Varicella Vaccination Programs. Herpes. 2007 Sep;14 Suppl 2:48-51. SA. Remple V, Patrick DM et al Conducting HIV/AIDS Research with Indoor Commercial Sex Workers: Reaching a Hidden Population. Progress in Community Health Partnerships: Research, Education, and Action 2007; 1(2): 161-168. CA. Ogilvie GS, Remple VP, Marra F, McNeil SA, Naus M, Pielak KL, Ehlen TG, Dobson SR, Money DM, Patrick DM. Parental intention to have daughters receive the human papillomavirus vaccine. Can Med Assoc J 2007; 177(12):1506-12. CA. Dhalla S, Woods R, Strathdee SA, Patrick DM, Hogg RS. HIV vaccine preparedness studies in the organization for economic co-operation and development (OECD) countries. AIDS Care 2007; 19(9):1118-27. Epub 2007 Jun 13. CA. Morán-Mendoza O, Marion SA, Elwood K, Patrick DM, FitzGerald JM. Tuberculin skin test size and risk of tuberculosis development: a large population-based study in contacts. Int J Tuberc Lung Dis. 2007; 11(9):1014-20. CA.

UBC Department of Medicine Page 222 Annual Report 2007

Quan G, Gilbert M, David ST, Rahim T, Adie K, Shaw C, McNabb A, Isaac-Renton J, Patrick DM. Usefulness of pulsed-field gel electrophoresis in tracking two outbreaks of invasive meningococcal disease serogroup C in British Columbia. Can J Infect Dis Med Microbiol 18(6): 363-367. CA. Edgar BL, Galanis E, Kay C, Skowronski D, Naus M, Patrick D. The burden of varicella and zoster in British Columbia 1994-2003: baseline assessment prior to universal vaccination. Can Commun Dis Rep. 2007; 33(11):1-15. CA. Shahidi N, Dhaliwal J, Tyrrell G, Hoang L, Patrick DM. Trends in incidence of invasive pneumococcal disease following introduction of the universal infant inmmunization program in British Columbia, 2002-2006. BC Med J 2008; 50(1): 18-21.

Phillips, Dr. Peter Godoy M, Rouse H, Brown J, Phillips P, Forrest D, Müller N. Imaging features of pulmonary Kaposi Sarcoma-associated immune reconstitution syndrome. Am J Roentgenology 2007;189:956-65.

Reiner, Dr. Neil E Nandan, D, M Lopez, F Ban, M Huang, Y Li, NE Reiner and A Cherkasov (2007), Indel-Based Targeting of Essential Proteins in Human Pathogens That Have Close Host Orthologue(s). Discovery of Selective Inhibitors for Leishmania donovani Elongation Factor-1a. Proteins. 67(1): 53-64. Lee, JS, WM Nauseef, A Moeenrezakhanlou, LM Sly, #S Noubir, KG Leidal, JM Schlomann, G Krystal and NE Reiner (2007) Monocyte p110x phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase and cytokine production. J. Leuk. Biol. 81: 1548-1561 Moeenrezakhanlou, A, D Nandan and NE Reiner (2007) Induction of monocyte CD14 expression in response to 1 ,25-dihydroxycholecalciferol involves activation of CREB downstream of phosphatidylinositol 3-kinase. J. Leuk. Biol. 81: 1311-1321. Ma, W, Mishra, S, Gee, K, Mishra, J.P., Nandan, D, NE Reiner, Angel, J.B., Kumar, A. (2007) Cyclosporin A and FK506 Inhibit IL-12p40 Production through the Calmodulin/Calmodulin-dependent Protein Kinase-activated P13K in LPS-Stimulated Human Monocytic Cells. J. Biol Chem. 282: 13351- 13362.

Rekart, Dr. Michael L Ogilvie G, Krajden M, Maginley, J, Issac-Renton J, Hislop G, Elwood-Martin R, Sherlock C, Taylor D, Rekart ML. Feasibility of self-collection of specimens for human papillomavirus testing in hard-to-reach women. Can Med Assoc J 2007; 177(5): 480-2.

Steiner, Dr. Theodore S Steiner TS. How flagellin and TLR5 contribute to enteric infection. Infect. Immun. 2007;75(2):545-52. Steiner TS, Ivison SM, Graham NR, Bernales CQ, Kaleem A, and Khan MAS. A phosphorylation site within the Toll-like receptor 5 Tir domain is required for inflammatory signalling in response to flagellin. Biochem. Biophys. Res. Comm. 2007; 352(4):936-41. Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R, Roncarolo MG, Levings MK. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol. 2007 Apr;19(4):345-54. Epub 2007 Feb 27 Ivison SM, Graham NR, Bernales CQ, Kifayet A, Ng N, Shobab LA, Steiner TS. Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. J Immunol. 2007 May 1;178(9):5735-43.

Tyndall, Dr. Mark W Wood E, Lloyd-Smith E, Li K, Strathdee SA, Small W, Tyndall MW, Montaner JSG, Kerr T. Frequent needle exchange use and HIV incidence in Vancouver, Canada. Am J of Med Am J Med 2007; 120(2):172-9.

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Kerr T, Fairbairn N, Tyndall M, Marsh D, Li K, Montaner J, Wood E. Predictors of non-fatal overdose among a cohort of polysubstance-using injection drug users. Drug Alcohol Depend. 2007; 87(1):39-45 Stoltz JA, Wood E, Small W, Li K, Tyndall M, Montaner J, Kerr. Changes in injecting practices associated with the use of a medically supervised safer injection facility. J Public Health 2007; 29(1):35-9. Firestone Cruz M, Fischer B, Patra J, Kalousek K, Newton-Taylor B, Rehm J, Tyndall M. Prevalence and associated factors of hepatitis C infection (HCV) in a multi-site canadian population of illicit opioid and other drug users (OPICAN). Can J Public Health 2007; 98(2):130-3. Petrar S, Kerr T, Tyndall MW, Zhang R, McKnoght B, Montaner JS, Wood E. Injection drug user's perceptions regarding use of medically supervised safer injecting facility. Addictive Behaviours 2007; 32(5):1088-93. Grebely J, Conway B, Raffa JD, Lai C, Krajden M, Tyndall MW. Reply: Hepatitis C Virus reinfection. Hepatology 2007; 45(5):1331. McKnight I, Maas B, Wood E, Tyndall MW, Small W, Lai C, Montaner JS, Kerr T. Factors associated with public injecting among users of Vancouver's supervised injection facility. Am J Drug Alcohol Abuse 2007;33(2):319-25. Wood E, Tyndall MW, Zhang R, Montaner JS, Kerr T. Rates of detoxification service use and its impact among a cohort of supervised injecting facility users. Addiction 2007; 102(6):916-9. Remple VP, Patrick DM, Johnston C, Tyndall MW, Jolly AA. Clients of Indoor Commercial Sex Workers: Heterogeneity in Patronage Patterns and Implications for HIV and STI Propagation Through Sexual Networks. Sex Transm Dis 2007; 34(10):754-60. Kerr T, Tyndall MW, Zhang R, Lai C, Montaner JS, Wood E. Circumstances of First Injection Among Illicit Drug Users Accessing a Medically Supervised Safer Injection Facility. Am J Public Health 2007; 97(7):1228-30. Grebely J, Conway B, Raffa J, Lai C, Krajden M, Tyndall MW. Factors Associated With Spontaneous Clearance of HCV Among Illicit Drug Users. Can J Gastroenterology 2007; 21(7): 447-51. Tyndall MW, McNally M, Lai C, Zhang R, Wood E, Kerr T, Montaner JS. Directly observed therapy programs for antiretroviral treatment among injection drug users in Vancouver: Access, adherence and outcomes. Int J Drug Policy 2007; 18(4):281-7. Grebely J, Genoway KA, Raffa JD, Dhadwal G, Rajan T, Showler G, Kalousek K, Duncan F, Tyndall MW, Fraser C, Conway B, Fischer B. Barriers associated with the treatment of hepatitis C virus infection among illicit drug users. Drug Alcohol Depend. 2007; 93(1-2):141-147. Blades R, Li K, Kerr T, Tyndall MW, Montaner JS, Wood E. Contribution of HIV to mortality among injection drug users in the era of HAART. J Acquir Immune Defic Syndr. 2007; 46(5):655-6. Shannon K, Bright V, Allinott S, Alexson D, Gibson K, Tyndall MW. Community-based HIV prevention research among substance-using women in survival sex work: The Maka Project Partnership. Harm Reduct J. 2007; 4(1):20-27. Shannon K, Kerr T, Allinott S, Chettiar J, Shoveller J, Tyndall MW. Social and structural violence and power relations in mitigating HIV risk of drug-using women in survival sex work. Soc Sci Med. 2007; Dec 20; [Epub ahead of print]. Kerr T, Tyndall MW, Zhang R, Lai C, Montaner JS, Wood E. Circumstances of first injection among illicit drug users accessing a medically supervised safer injection facility. Am J Public Health 2007; 97(7):1228-30. Wood E, Kerr T, Tyndall MW, Zhang R, Hogg RS, Strathdee SA, Montaner JS. Rates of HIV/AIDS care and antiretroviral therapy response among active injection drug users. Addiction 2007;102(9):1503-5.

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MEDICAL ONCOLOGY

Bernstein, Dr. Vanessa Coulombe G, Tyldesley S, Speers C, Paltiel C, Aquino-Parsons C, Bernstein V, Truong PT, Keyes M, Olivotto IA. Is mastectomy superior to breast conserving treatment for young women? International Journal of Radiation Oncology, Biology, Physics. 67 (5): 1282-90, April 1 2007.

Connors, Dr. Joseph M Sehn LH, Berry B, Chhanabhai M, Fitzgerald C, Gill K, Hoskins P, Klasa R, Savage KJ, Shenkier T, Sutherland J, Gascoyne RD, Connors JM. The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP. Blood 2007;109:1857-61. Ramadan KM, Shenkier T, Sehn LH, Gascoyne RD, Connors JM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol 2007;18:129-35. Song K, Barnett M, Gascoyne R, Chhanabhai M, Forrest D, Hogge D, Lavoie J, Nantel S, Nevill T, Shepherd J, Smith C, Sutherland H, Toze C, Voss N, Connors JM. Primary therapy for adults with T-cell lymphoblastic lymphoma with hematopoietic stem-cell transplantation results in favorable outcomes. Ann Oncol 2007; 18:535-40. Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M, Diehl V. Revised response criteria for malignant lymphoma. J Clin Oncol 2007; 25: 579-586. Sehn LH, Donaldson J, Filewich A, Fitzgerald C, Gill KK, Runzer N, Searle B, Souliere S, Spinelli JJ, Sutherland J, Connors JM. Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting. Blood 2007:109:4171-3. Wiestner A, Tehrani M, Chiorazzi M, Wright G, Gibellini F, Nakayama K, Liu H, Rosenwald A, Muller-Hermelink HK, Ott G, Chan WC, Greiner TC, Weisenburger DD, Vose J, Armitage JO, Gascoyne RD, Connors JM, Campo E, Montserrat E, Bosch F, Smeland EB, Kvaloy S, Holte H, Delabie J, Fisher RI, Grogan TM, Miller TP, Wilson WH, Jaffe ES, Staudt LM. Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. Blood 2007;109:4599-606. Assouline S, Meyer RM, Infante-Rivard C, Connors JM, Belch A, Crump M, et al. Development of adapted RECIST criteria to assess response in lymphoma and their comparison to the International Workshop Criteria. Leuk Lymphoma 2007; 48:513-20. Rimsza LM, Farinha P, Fuchs DA, Masoudi H, Connors JM, Gascoyne RD. HLA-DR protein status predicts survival in patients with diffuse large B-cell lymphoma treated on the MACOP-B chemotherapy regimen. Leuk Lymphoma 2007; 48:542-6. Novik KL, Spinelli JJ, Macarthur AC, Shumansky K, Sipahimalani P, Leach S, Lai A, Connors JM, Gascoyne RD, Gallagher RP, Brooks-Wilson AR. Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma. Cancer epidemiology, biomarkers & prevention 2007; 16:1098-106. Wilson KS, Sehn LH, Berry B, Chhanabhai M, Fitzgerald CA, Gill KK, Klasa R, Skinnider B, Sutherland J, Connors JM, Gascoyne RD. CHOP-R therapy overcomes the adverse prognostic influence of BCL-2 expression in diffuse large B-cell lymphoma. Leuk Lymphoma 2007;48:1102- 1109. Iqbal J, Greiner TC, Patel K, Dave BJ, Smith L, Ji J, Wright G, Sanger WG, Pickering DL, Jain S, Horsman DE, Shen Y, Fu K, Weisenburger DD, Hans CP, Campo E, Gascoyne RD, Rosenwald A, Jaffe ES, Delabie J, Rimsza L, Ott G, Muller-Hermelink HK, Connors JM, Vose JM, McKeithan T, Staudt LM, Chan WC. Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia 2007;21:2332-43.

UBC Department of Medicine Page 225 Annual Report 2007

Sipahimalani P, Spinelli J, MacArthur A, Lai A, Leach S, Janoo-Gilani R, Palmquist D, Connors JM, Gascoyne R, Gallagher R, Brooks-Wilson A. A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma. Int J Cancer. 2007;121:1967-75. Kimm LR, deLeeuw RJ, Savage KJ, Rosenwald A, Campo E, Delabie J, Ott G, Muller-Hermlink HK, Jaffee ES, Rimsza LM, Weisenburger DD, Chan WC, Staudt LM, Connors JM, Gascoyne RD, Lam WL. Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. Genes Chrom Cancer 2007;48:1090-7. Spinelli JJ, Ng CH, Weber J-P, Connors JM, Gascoyne RD, Lai AS, Brooks-Wilson AR, Le ND, Berry BR, Gallagher RP. Organochlorines and risk of non-Hodgkin lymphoma. Int J Cancer 2007:121:2767-75. Macdonald DA, Connors JM. New strategies for the treatment of early stages of Hodgkin's lymphoma. Hematol Oncol Clin North Am. 2007;21:871-80. Macdonald DA, Ding K, Gospodarowicz MK, Wells WA, Pearcey RG, Connors JM, Winter JN, Horning SJ, Djurfeldt MS, Shepherd LE, Meyer RM. Patterns of disease progression and outcomes in a randomized trial testing ABVD alone for patients with limited-stage Hodgkin lymphoma. Ann Oncol 2007;18:1680-4.

Gelmon, Dr. Karen A Robinson, Andrew, Thomson T, Ellard S, Bajdik C, Yorida E, Turbin D, Huntsman D , Gelmon Karen. Molecular Prognostic and Predictive Factors in patients undergoing trastuzumab based chemotherapy for metastatic breast cancer. Clinical Breast Cancer 2006; 7(3): 254-261. Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, Ladha AB, Proulx C, Vallance JK, Lane K & , MacKenzie DC Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. Jour Clin Onco. 2007; 25(28): 4306-404. Ian Smith, Marion Procter, Richard D Gelber, Sebastien Guillaume, Andrea Feyereislova, Mitch Dowsett, Aron Goldhirsch, Michael Untch, Gabriella Mariani, Jose Baselga, Manfred Kaufmann, David Cameron, Richard Bell, Jonas Bergh, Robert Coleman, Andrew Wardley, Nadia Harbeck, Roberto I Lopez, Pter Mallmann, Karen Gelmon, Nicholas Wilcken, Erik Wist, Pedro Sanchez Rovira, Martine J Piccart-Gebhart for the HERA Study Team. 2 year follow-up of trastuzumab after adjuvant therapy with chemotherapy in HER2 positive breast cancer: a randomized controlled trial. Lancet 2007; 369: 29-36 Dagowksa, WH, Verreault M, Yapp DTT, Warburton C, Edwards L, Ramsay EC, Huxhuam LA, Minchinton A, Gelmon K, Bally M. Decreased levels of hypoxic cells in gefitinib treated ER+ Her-2 overexpressing MCF-7 breast cancer tumours are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with rapamycin. Breast Cancer Res Treat 2007;(epub ahead of print) Campbell KL, Lane K, Martin AD, Gelmon KA, McKenzie DC. Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer. Cancer Nurs 2007; 30(2): 95-100 Pansegrau GK, Grant DR, Norris B, Gelmon KA. Trastuzumab associated peripheral vascular toxicity. J Clin Oncol 2007 10; 25 (11): 1438 - 40. Munster Pamela, Britten Carolyn D, Mita Monica, Gelmon Karen, Minton Susan E, Moulde Stacey, Slamon Dennis, Guo Feng, Letrent Stephen P, Denis Louis, Tolcher Anthony W. First-in-Human Study of the Safety and Tolerability and Pharmacokinetics of CP-724,714 in Patients with Advanced Malignant Solid Tumors that Express HER2, Clinical Cancer Research, 2007 15; 13(4): 1238-45. Chia SK, Speers CH, D'yachkova Y, Kang A, Malfair-Taylor S, Barnett J, Coldman A, Gelmon KA, O'Reilly SE, Olivotto IA. The impact of new chemotherapeutic and hormone agents on surivival in a population based cohort of women with metastatic breast cancer. Cancer 2007; 110 (5): 973-9.

UBC Department of Medicine Page 226 Annual Report 2007

Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, Ladha AB, Proulx C, Vallance JK, Lane K &, MacKenzie DC Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. Jour Clin Onco. 2007; 25(28): 4306-404 Kennecke HF, Olivotto IA, Speers C, Norris B, Chia SK, Bryce C, Gelmon KA. Late risk of relapse and mortality among postemenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen. Ann Oncol 2007; 8 (1): 45-51. Gelmon K. Prescribing extended adjuvant letrozole. Breast 2007; 16(5): 446-55. Guo F, Letrent SP, Munster PN, Britten CD, Gelmon K, Tolcher AW, Sharma A. Pharmacokinetics of a HER2 tyrosine kinase inhibitor, CP-724,714 in patients with advanced malignant HER2 positive solid tumors; correlations with clinical characteristics and safety. Cancer Chemother Pharmacol. 2007; (epub ahead of print). Courneya KS, Segal, R, Gelmon K, Reid R, Mackey J, Friedenreich CM, Proulx C, Lane K, Ladha AB, Vallance JK, Lui Q, Yasui Y, McKenzie DC. Six month follow-up of patient rated outcomes in a randomized controlled trial of exercise training during breast cancer chemotherapy. Cancer Epidemiology, Biomarkers and Prevention, 2007; 16: 2572-2578. Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. Quantitative justification of the change from 10% - 30 % for HER2 scoring in the ASCO-CAP guidelines: tumour heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. Accepted Jour Clin Oncol, 2007; 25 (34): 5418-25. Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, Ladha AB, Proulx C, Vallance JK, Lane K, Yasui Y, Segal RJ. Moderators of the effects of exercise training in breast cancer patients receiving chemotherapy: a randomized controlled trial Accepted Cancer, 2007. Dranitsaris G, Rayson D, Vincent M, Chang J, Gelmon K, Sandor D, Reardon G. The development of a predictive model to estimate cardiotoxic risk for patients with metastatic breast cancer receiving anthracyclines. Breast Cancer Res Treat 2007; 13; epub ahead. Perez EA, Suman VJ,. Davidson NE, Sledge GW,. Kaufman PA,. Hudis CA, Martino S, . Gralow JR, Dakhil SR, Ingle JN, Winer EP, Gelmon KA,. Gersh BJ, Jaffe AS, Rodeheffer RJ. Cardiac Safety Analysis of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With or Without Trastuzumab in the North Central Cancer Treatment Group N9831 Adjuvant Breast Cancer Trial , accepted JCO 2007. Crabb SJ, Chia S, Gelmon K. Current questions and uncertainty in the treatment of HER2 positive breast cancer. accepted Breast Cancer Treatment and Research 2007. Dranitsaris G, Rayson D, Vincent M, Chang J, Gelmon K, Sandor D, Reardon G. Identifying patients at high risk for neutropenic complications during chemotherapy for metastatic breast cancer with doxorubicin or pegylated liposomal doxorubicin: the development of a predictive model. Accepted JCO 2007.

Gill, Dr. Karamjit K Sehn LH, Berry B, Chhanabhai M, Fitzgerald C, Gill KK, et al. Revised International Prognostic Index (R-IPI) is a Better Predictor of Outcome than the Standard IPI for Patients with Diffuse Large B-Cell Lymphoma treated with R-CHOP. Blood. 109(5):1857-61, 2007. Sehn LH, Donaldson J, Filewich A, Fitzgerald C, Gill KK, et al. Rapid Infusion Rituximab in Combination with Corticosteroid Chemotherapy or as Maintenance Therapy is Well Tolerated and can Safely be Delivered in the Community Setting. Blood. Prepublished online Jan 23, 2007.

Gill, Dr. Sharlene Gill S, Blackstock W, Goldberg RM. Update in Colorectal Cancer Review, Mayo Clinic Proceedings, Jan 2007; 82 (1): 114-129.

UBC Department of Medicine Page 227 Annual Report 2007

Hart, Dr. Jason Jason Hart, A. Robert Turner, Loree Larratt, James Russell, Bevin Franko, Christine Frantz, Teresa Paonessa, Adnan Mansoor, Raymond Lai. Transmission of a follicular lymphoma by allogeneic bone marrow transplantation supporting the existence of lymphoma progenitor cells. British Journal of Hematology 2007;136 (1), 166-167.

Ho, Dr. Cheryl Pugh TJ , Bebb G, Barclay L, Sutcliffe M, Fee J, Salski C, O'Connor R, Ho C, Murray N, Melosky B, English J, Vielkind J, Horsman D, Laskin JL, Marra MA. Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients BMC Cancer 2007 July, 7:128. Ho C, Davies AM and Gandara DR. Dual epidermal growth factor inhibition: Combining tyrosine kinase inhibitors and monoclonal antibodies in non-small cell lung cancer therapy. Clin Lung Cancer July:8(7):420-424, 2007. Davies AM, Ho C, Hesketh P, Lara PN, Lau DH, Galvin I, Gumerlock PH and Gandara DR. Erlotinib and vinorelbine in advanced solid tumors: A phase I study. Invest New Drugs 2007 Aug;25(4):351-5. Davies AM, Ho C, Metzger AS, Beckett LA, Christensen S, Tanaka M, Lara PN, Lau DH and Gandara DR. Phase I study of two different schedules of bortezomib and pemetrexed in advanced solid tumors with emphasis on non-small cell lung cancer (NSCLC). J Thorac Oncol. 2007 .Dec;2(12):1112-6. Ho C, Ochsenbein AF, Gautschi O, Davies AM. Early Clinical Trial Experience with Vaccine Therapies in Non-small Cell Lung Cancer. Clin Lung Cancer 2008 Feb:9(Suppl 1):S20-S27.

Kennecke, Dr. Hagen F Kennecke H, Olivotto I, Speers C, Norris B, Chia S, Bryce C, Gelmon K. Late risk of relapse and mortality among postmenopausal women with estrogen responsive early breast cancer after 5 years of tamoxifen. Annals of Oncology 18(1):45-51, 2007 Jan.

Klasa, Dr. Richard J Sehn LH. Berry B. Chhanabhai M. Fitzgerald C. Gill K. Hoskins P. Klasa R. Savage KJ. Shenkier T. Sutherland J. Gascoyne RD. Connors JM. The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP. [Journal Article. Research Support, Non-U.S. Gov't] Blood. 109(5):1857-61, 2007 Mar 1. Chiu GN, Edwards LA, Kapanen AI, Malinen MM, Dragowska WH, Warburton C, Chikh GG, Fang KY, Tan S, Sy J, Tucker C, Waterhouse DN, Klasa R, Bally MB. Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs. Mol Cancer Ther 2007;6:844-55. Wilson KS. Sehn LH. Berry B. Chhanabhai M. Fitzgerald CA. Gill KK. Klasa R. Skinnider B. Sutherland J. Connors JM. Gascoyne RD. CHOP-R therapy overcomes the adverse prognostic influence of BCL-2 expression in diffuse large B-cell lymphoma.[see comment]. [Evaluation Studies. Journal Article. Research Support, Non-U.S. Gov't] Leukemia & Lymphoma. 48(6):1102-9, 2007 Jun.

Kommareddy, Dr. Aruna Marcom PK, Isaacs C, Harris L, Wong ZW, Kommarreddy A, Novielli N, Mann G, Tao Y, Ellis MJ.The combination of letrozole and trastuzumab as first or second-line biological therapy produces durable responses in a subset of HER2 positive and ER positive advanced breast cancers. Breast Cancer Research and Treatment. 2007 Mar;102(1):43-9.

Laskin, Dr. Janessa J T. J. Pugh, G. Bebb, L. Barclay, M. Sutcliffe, J. Fee, C. Salski, R. O'Connor, C. Ho, N. Murray, B. Melosky, J.English, J. Vielkind, D. Horsman, J. J Laskin and M. A. Marra. "Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective

UBC Department of Medicine Page 228 Annual Report 2007

analysis of lung cancer patients". BMC Cancer 2007, 7:128 (13 Jul 2007). D.N. Ionescu; D. Traeba, C.B. Gilks, S. Leung, D. Renouf, J. Laskin, R. Wood-Baker, A.M. Gown. Non-small Cell Lung Carcinoma With Neuroendocrine Differentiation-An Entity of No Clinical or Prognostic Significance. Am J Surg Pathol. 2007 Jan;31(1):26-32.

Lee, Dr. Christopher W Smylie MG, Wong R, Mihalcioiu C, Lee C, Pouliot J-F. A phase II, open label, monotherapy study of liposomal doxorubicin in patients with metastatic malignant melanoma. Invest New Drugs 2007; 25: 155-159. Arnold AA, Seymour L, Smylie M, Ding K, Ung Y, Findlay B, Lee CW, Djurfeldt M, Whitehead M, Ellis P, Goss G, Chan A, Meharchand J, Alam Y, Gregg R, Butts C, Langmuir P, Shepherd F. Phase II trial of vandetanib or placebo in small-cell lung cancer patients after complete or partial response to induction chemotherapy with or without radiation therapy: National Cancer Institute of Canada Clinical Trials Group study BR.20. J Clin Oncol 2007; 25: 4278-4284. Lee CW, Belanger K, Rao SC, Petrella TM, Tozer RG, Wood L, Savage KJ, Eisenhauer EA, Synold TW, Wainman N, Seymour L. A phase II study of SB-715992 in patients with metastatic or recurrent malignant melanoma: A National Cancer Institute of Canada Clinical Trials Group trial. Invest New Drugs 2007 Oct 26 [Epub ahead of print].

Lee, Dr. Ursula J Lyly L, Kenneth S, Laurie Elit, Diane Procencher, Gavin Stuart, Tien Le, Ursula Lee, Angela Rodgers, Gregory Pond, Amit Oza. "Phase II multicentre open-label study of Carboplatin and Pegylated Liposomal Doxorubicin in Uterine and Cervical Malignancies." International Journal of Gynecologic Oncology, Sep-Oct 2005 Vol 15(5),pp799-806

Melosky, Dr. Barbara L Lacouture ME, Melosky BL. Cutaneous Reactions to Anticancer Agents Targeting the Epidermal Growth Factor Receptor: A Dermatology-Oncology Perspective. Skin Therapy Letter July-Aug 2007;12(6)1-10. Pugh TJ, Bebb G, Barclay L, Sutcliffe M, Fee J, Salski C, O’Connor R, Ho C, Murray N, Melosky B, English J, Vielkind J, Horsman D, Laskin JJ, Marra MA. Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients. BMC Cancer 2007 Jul 13;7(1):128. Mikhael J, Melosky B, Cripps C, Rayson D, Kouroukis CT. “Canadian Supportive Care Recommendations for the Management for the Management of Anemia in Patients with Cancer.” Current Oncology 2007;14(5)209 17. Trevor J Pugh, Gywn Bebb, Lorena Barclay, Margaret Sutcliffe, John Fee, Chris Salski, Robert O’Connor, Cheryl Ho, Nevin Murray, Barbara Melosky, John English, Jeurgen Vielkind, Doug Horsman, Janessa J Laskin, Maro A Marra. Retrospective validation of the ability of EGFR mutation or increases in EGFR and HER2 copy number to predict response in a cohort of lung cancer patients. BMC Journal 2007 Giaccone G, Melosky B, Reck M. Epidermal Growth Factor Receptor Inhibitor (EGFRI)-associated rash: a suggested novel management paradigm. A consensus position from the EGFRI Dermatologic Toxicity Forum 2007.

Pansegrau, Dr. Gary K Pansegrau GK, Grant DR, Norris B, Gelmon KA. Trastuzumab-Associated Peripheral Vascular Toxicity. J Clin Oncol 25:1438-40, 2007.

UBC Department of Medicine Page 229 Annual Report 2007

Savage, Dr. Kerry J Rodig SJ, Savage KJ* , LaCasce AS, Weng AP, Harris NL, Shipp MA, Hsi ED, Gascoyne RD, and Kutok JL. Expression Of TRAF1 And Nuclear c-Rel Distinguishes Primary Mediastinal Large Cell Lymphoma From Nodal Diffuse Large B Cell Lymphoma. American Journal of Surgical Pathology. 2007. 31(1). 106-112. *shared co-first authorship. Savage KJ Peripheral T-cell Lymphomas. Blood Reviews. 2007; 21 (4): 201-16. Kimm LR1, deLeeuw R1, Savage KJ2, Rosenwald A., Campo E, Delabie J, Muller-Hermelink HK, Jaffe ES, Rimsza LM, Weisenburger DD, Chan WC, Staudt LM, Gascoyne RD, Lam WL. Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. 1 These authors contributed equally. Genes, chromosomes cancer. Sept 2007 Epub. Lee CW, Belanger K, Rao S, Petrella TM, Tozer RG, Wood L, Savage KJ, Eisenhauer E, Synoid TW, Wainman N, Seymour L. A phase II study of ispinesib (SB-715992) in patients with metastatic or recurrent malignant melanoma: a National Cancer Institute of Canada Clinical Trials Group trial.

Sehn, Dr. Laurie H Belch A, Kouroukis CT, Crump M, Sehn L, Gascoyne RD, Klasa R, Powers J, Wright J, Eisenhauer, E. A. A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150. Ann Oncol Sept 18, 116-21, 2007. Ramadan K M, Shenkier T, Sehn LH, Gascoyne, RD, Connors JM. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann Oncol 18, 129-35, 2007. Sehn LH, Donaldson J, Filewich A, Fitzgerald C, Gill KK, Runzer N, Searle B, Souliere S, Spinelli JJ, Sutherland J, Connors JM. Rapid infusion rituximab in combination with corticosteroid containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting. Blood 109, 1857-61, 2007. Shah, Dr. Amil M Dranitsaris G, Shah A, Spirovski B, Vincent M. Severe diarrhea in patients with advanced colorectal Cancer receiving FOLFOX of FOLFIRI chemotherapy: development of a risk prediction tool. Clin Colorectal Cancer 6(5): 367-373, 2007. Lim H, Shah A. 5-Fluoruoracil-Fifty year on. Oncology Exchange 6(3); 30-35, 2007.

Shenkier, Dr. Tamara N KM Ramadan, T Shenkier, LH Sehn, RD Gascoyne, and JM Connors. A clinicopathological retrospective study of 131 patients with primary bone lymphoma: a population-based study of successively treated cohorts from the British Columbia Cancer Agency. Ann. Onc., January 2007; 18: 129 - 135. Laurie H. Sehn, Brian Berry, Mukesh Chhanabhai, Catherine Fitzgerald, Karamjit Gill, Paul Hoskins, Richard Klasa, Kerry J. Savage, Tamara Shenkier, Judy Sutherland, Randy D. Gascoyne, and Joseph M. Connors. The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.Blood, Mar 2007; 109: 1857 - 1861. Grimm, J. S. Pulido, K. Jahnke, D. Schiff, A. J. Hall, T. N. Shenkier, T. Siegal, N. D. Doolittle, T. Batchelor, U. Herrlinger, E. A. Neuwelt, N. Laperriere, M. C. Chamberlain, J. Y. Blay, A. J. M. Ferreri, A. M. P. Omuro, E. Thiel, and L. E. Abrey. Primary intraocular lymphoma: an International Primary Central Nervous System Lymphoma Collaborative Group Report. Ann. Onc., November 2007; 18: 1851 - 1855. Miller K, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA, Shenkier T, Cella D, Davidson NE. Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer. . N Engl J Med 357:2666, December 27, 2007.

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Weinerman, Dr. Brian H Johanna den Duyf, MA, Jeff, Barnett, Brian Weinerman, MD, FRCPC TELEONCOLOGY: Examining telemedicine as a viable alternative health service delivery for cancer patients. Published in Proceeding Information Technology in Community Health Conference - February 2007 Orrom WJ, Hayashi AH, Kueschler D, Ross AC, Kueschler PM, Larsson S, Rusnak CH, Weinerman B. The surgical managment of rectal cancer: a comparison of treatment methods and outcomes over 2 time periods in the same geographic region. Am J Surg May;193(5):623-6, 2007.

Wilson, Dr. Kenneth S Wilson K S, Fitzgerald C A, Barnett J B, Gill S, Khoo K E. Adjuvant therapy with raltitrexed in patients with colorectal cancer intolerant of 5-fluorouracil: British Columbia Cancer Agency experience. Cancer Investigation 2007, 25, 8, 711-714.

MEDICINE

Ashton, Dr. Thomas Ashton, TH. Canadian Cardiovascular Society Consensus Conference Recommendations on heart failure update 2007: Prevention, management intercurrent illness or acute decompensation use biomarkers. Secondary Panelist Can J Cardiol 2007; 23(1): 21-45. Ashton TH, Karr G, Arsenault B, Wilkinson S, Cooper S, Serwa NDoing More with Less: Managing the Cardiovascular Cluster of Disease in an Integrated Healthcare Clinic. CJ GIM.

Chan, Dr. Albert W Chan AW. Treatment of Severe Functional Mitral Regurgitation: Is Cardiac Surgery Always Indicated? J Invas Cardiol 2007;19:E286-9.

Guzman, Dr. Jaime Guzmán J, Hayden J, Furlan A, Cassidy D, Loisel P, Flannery, Gibson J, Frank, J. Key Factors in Back Disability Prevention: A Consensus Panel on Their Impact and Modifiability. Spine 2007 Apr 1;32(7):807-15. Dehaan MN, Guzman J, Bayley MT, Bell MJ. Knee Osteoarthritis Clinical Practice Guidelines -- How Are We Doing? J Rheumatol. 2007 Oct;34(10):2099-2105. Epub 2007 Aug 15. Guzmán J, Jones D, Cassidy JD, Furlan A, Loisel P, Frank JW. Key Factors in Back Disability Prevention: What influences their relative prioritization? Spine 2007 Apr 20;32(9):E281-9. van der Velde G, van Tulder M, Cote P, Hogg-Johnson S, Aker P, Cassidy JD; Scientific Secretariat of The Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders; Carragee E, Carroll L, Guzman J, Haldeman S,Holm L, Hurwitz E, Nordin M, Peloso P. The sensitivity of review results to methods used to appraise and incorporate trial quality into data synthesis. Spine. 2007 Apr 1;32(7):796-806.

Klinke, Dr. Wolf P Ziakas A, Klinke P, Mildenberger R, Fretz E, Williams M, Siega AD, Kinloch D, Hilton D. Safety of Same Day Discharge Radial PCI in Patients Under and Over 75 Years of Age. Int. Heart J. 2007 Sep;48(5):569-78 J Margolis, J McDonald, R Heuser, WP Klinke, R Waksman, R Virmani, N Desai, JD Hilton. Systemic Nanoparticle Paclitaxel (nab-Paclitaxel) for In-stent Restenosis I (SNAPIST-I): A First-in-Human Safety and Dose-finding Study. Clin. Cardiol. 2007; 30: 165-170.

UBC Department of Medicine Page 231 Annual Report 2007

Small Andrew, Klinke Peter, Della Siega Anthony, Fretz Eric, Kinloch David, Mildenberger Richard, Williams Malcolm, Hilton David. Day Procedure Intervention is Safe and Complication Free in Higher Risk Patients Undergoing Transradial Angioplasty and Stenting; The DISCHARGE Study. Catheterization and Cardiovascular Interventions. 2007: 907-912. Published online July 9, 2007. DOI: 10.1002/ccd.21277. Paul W. Armstrong et al for the APEXS AMI Investigators. Pexelizumab for Acute ST- Elevation Myocardial Infarction in Patients Undergoing Primary Percutaneous Coronary Intervention. JAMA. January 3, 2007 - Vol. 297, No. 1. Prakash Deedwania et al for the SAGE Investigators. Effects of Intensive Versus Moderate Lipid-Lowering Therapy of Myocardial Ischemia in Older Patients With Coronary Heart Disease - Results of the Study Assessing Goals in the Eldery (SAGE). Circulation, DOI: 10.1161/Circulation.106.654756. February 13, 2007. Michael J. Koren, Michael R. Crager, Michael Sweeney for the ROLE Investigators. Long-Term Safety of a Novel Antianginal Agent in Patients With Severe Chronic Stable Angina - The Ranolazine Open Label Experience (ROLE). J Am Coll Cardiol 2007:49:1027-34 Vol 49, No 10. March 13, 2007. Mihai Gheorghiade et al for the Everest Investigators. Short-term Clinical Effects of Tolvaptan, an Oral Vasopressin Antagonist, in Patients Hospitalized for Heart Failure. JAMA, March 28, 2007-Vol. 297, No. 12. Jean-Claude Tardif et al for the Erase Investigators. Effects of Reconstituted High-Density Lipoprotein Infusions on Coronary Atherosclerosis. JAMA, Published Online: March 26, 2007 (doi: 10.1001/jama.297.15.jpc70004). Stephen E. Nissen et al for the ILLUSTRATE Investigators. Effect of Torcetrapib on the Progression of Coronary Atherosclerosis. N Engl J Med, 2007. David A. Morrow et al for the Merlin-TIMI 36 Investigators. Effects of Ranolazine on Recurrent Cardiovascular Events in Patients With Non-ST-Elevation Acute Coronary Syndromes. JAMA, April 25, 2007-Vol 297, No. 16. Kwan-Leung Chan et al for the ASTRONOMER Investigators. Rationale, Design, and Baseline Characteristics of a Randomized Trial to Assess the Effect of Cholesterol Lowering on the Progression of Aortic Stenosis: The Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin trial. AHJ June 2007-Vol 153, No 6. Marvin A. Kosnstam et al for the EVEREST Investigators. Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure, The EVEREST Outcome Trial. JAMA 2007 - Vol 297, No 12. Mihai Gheorghiade et al for the EVEREST Investigators. Short-term Clinical Effects of Tolvaptan, an Oral Vasopressin Antagonist, in Patients Hospitalized for Heart Failure – The EVEREST Clinical Status Trials. JAMA 2007- Vol 297, No 12. Ziakas A, Gomma A, McDonald J, Klinke P, Hilton D. A comparison of the radial and the femoral approaches in primary or rescue percutaneous coronary intervention for acute myocardial infarction in the elderly. Acute Card Care 2007;9(2):93-6. Ziakas A, Klinke P, Mildenberger R, Fretz E, Williams M, Della Siega AD, Kinlock D, Hilton D. Safety of Same day discharge radial PCI in patients under and over 75 years of age. Int Heart J Sep 2007: 48(5):569-578.

Takaro, Dr. Timothy K Wu F and Takaro TK. Economic Impacts of Home Environmental Intervention on Childhood Asthma. Env. Health Persp. 115:971-5. 2007. Abbotts J, Takaro TK and Weems C. Formerly Utilized Sites Remedial Action Program Completed Sites: Lessons for Long-Term Stewardship. Remediation Journal 18: 83-96. 2007.

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Towle, Dr. Angela Towle A. Involving patients in the education of health professionals. Journal of Health Services Research and Policy 2007; 12 (1): 1-2.

NEPHROLOGY

Chan-Yan, Dr. Clifford Weber, CL, Frohlich, J, Wang, J, Hegele, RA & Chan-Yan, C: Stability of lipids on peritoneal dialysis in a patient with familial LCAT deficiency. Nephrol Dial Transplant, 22:2084-8, 2007.

Gill, Dr. John S Hemmelgarn BR, Chou S, Wiebe N, Culleton BF, Manns BJ, Klarenbach S, Khan NA, Gourishankar S, Yeates KE, Gill JS, Tonelli M. Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian, and white ESRD patients in Canada. Am J Kidney Dis. 2006 Dec;48(6):964-71. Erratum in: Am J Kidney Dis. 2007 Feb;49(2):348. Gill JS, Rose C, Pereira B, Tonelli M. The importance of transitions between dialysis and transplantation in the care of end-stage renal disease patients. Kidney Int. 2007 Mar;71(5):442-7. Solid C, Foley RN, Gill JS, Collins AJ. Epoetin use and Kidney Disease Outcomes Quality Initiative hemoglobin targets in patients returning to dialysis with failed renal transplants. Kidney Int. 2007 Mar;71(5):425-30.

Landsberg, Dr. David N Johnston O, Rose C, Landsberg D, Gourlay W, Gill JS: Nephrectomy after transplant failure: Current practice and outcomes. Am J Transplant., Aug 2007; 7(8):1961-7.

Levin, Dr. Adeera Levin A, Pate G, Shalansky S, Al-Shamari A, Webb J, Buller CEand Humphries K, "N-acetylcysteine reduces urinary albumin excretion following cotnrqst administration: evidence of biological effect", Nephrology Dialysis and Transplantation 2007 Sep; 22:2520-4. Nisha Bansal, Hocine Tighiouart, Daniel Weiner, John Griffith, Panagiotis Vlagopoulos, Deeb Salem, Adeera Levin, Mark J. Sarnak, "Anemia as a Risk Factor for Kidney Function Decline in Individuals with Heart Failure". American Journal of Cardiology 2007; 99:1137-42. Levin, A, Bakris, G, Molitch, M, Smulders, M, Tian, J, Williams, L, Andress, D, "Prevalence of Abnormal Vitamin D, PTH, Calcium and Phosphorus in Patients with CKD: Results of the Study to Evaluate Early Kidney Disease (SEEK)", Kidney International 2007 Jan: 71, 31-8. Van Wyck D, Eckardt K, Uhlig K, Rocco M, Levin A, "Appraisal of Evidence and Control of Bias in the Kidney Disease Outcomes Quality Initiative Guideline Development Process", CJASN. 2007 Jan; 2: 8-10. Van Wyck D, Eckardt K, Uhlig K, Rocco M, Levin A, "Response to ‘Influence of Industry on Renal Guideline Development". Clin J Am Soc Nephrol. 2007 Jan; 2:13-4. Levin A, "Understanding recent haemoglobin trials in CKD: methods and lesson learned from Create and Choir", NDT, 2007 Feb; 22(2): 309-12. Levin A, Bakris G, Molitch M, Smulders M, Tian J, Williams L, Andress D, "Prevalence of Abnormal Serum Vitamin D, PTH, Calcium and Phosphorus in Patients with Chronic Kidney Disease: Results of the study to Evaluate Early Kidney Disease", Kidney International 2007 Jan: 71, 31-8. RL Mehta , JA Kellum , SV Shah , BA Molitoris , C Ronco , DG Warnock, Levin A, "AKIN: Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury", Critical Care 2007 Mar 1; 11 (2): R31. Roger SD, Levin A, "Epoetin trials: randomized controlled trials don’t always mimic observational data", NDT. 2007 Mar; 22(3): 684-6.

UBC Department of Medicine Page 233 Annual Report 2007

Levin A, Luft F, Chapman A, Textor S, Linus S, "Controversies in Renal Artery Stenosis: A Review by the American Society of Nephrology Advisory group on Hypertension", American Journal of Nephrology 2007; 27 (2): 212-20. Levin A, "The Treatment of Anemia in Chronic Kidney Disease: understandings in 2006", Current Opinion in Nephrology and Hypertension, 2007 May; 16(3): 267-71. Barraclough K, Harris M, Montessori V, Levin A, "An unusual case of acute kidney injury due to vancomycin-lessons learnt from reliance on eGFR", NDT (ERA-EDTA), 2007 Apr. Booth A, Levin A, "Towards a better understanding of cardiac and vascular disease in patients with chronic kidney disease", Current Cardiology Reviews, Volume 3, Issue 2, May, 2007. Gill J, Malyuk R, Djurdjev O, Levin A, "Use of GFR equations to adjust drug doses in an elderly multi-ethnic group-a cautionary tale", NDT 2007 Oct; Vol 22, No. 10: 2894-9. Ronco C, Levin A, Warnock DG, Mehta RL, Kellum JA, Shah S, Molitoris BA and on behalf of the AKIN Working Group, "Improving outcomes from Acute Kidney Injury (AKI): Report on an intitiative", Editorial in The International Journal of Artificial Organs, 2007; 30 (5):000. Levin, A, "Response to 25 (OH) vitamin D deficiency amongst SE Asians and Caucasians with CKD 3&4, and it’s role in hyperparathryroidism", Kidney International, 2007. Ronco C, Levin A, Warnock DG, Mehta RL, Kellum JA, Shah S, Molitoris BA and on behalf of the AKIN Working Group, "Improving outcomes from Acute Kidney Injury (AKI): Report on an intitiative", Kidney International, 2007. Ronco C, Levin A, Warnock DG, Mehta RL, Kellum JA, Shah S, Molitoris BA and on behalf of the AKIN Working Group, "Improving outcomes from Acute Kidney Injury (AKI): Report on an intitiative", Pediatric Nephrology, 2007 Oct; Vol 22, No 10: 1655-8. Coyle D, Rodby R, Soroka S, Levin A, Muirhead N, DeCotret P, Chen R, "Cost-effectiveness of Irbesartan 300mg given early versus lat in patients with hypertension and a history of Type 2 Diabetes and Renal Disease: a Canadian perspective", Clinical Therapeutics, 2007. Mehta R, Molitoris B, Levin A, Editorial in NephSAP (Nephrology Self-Assessment Program) Journal: Acute Kidney Injury and Critical Care Nephrology, 2007 Sept; Vol 6, No 5. Komenda P, Levin A, Manns B, "The economics of home nocturnal hemodialysis: how should we cost the benefits?", Clinical Nephrology, 2007; Vol 68. Levey AS, Atkins R, Coresh J, Cohen EP, Collins AJ, Eckardt K-U, Nahas ME, Jaber BL, Jadoul M, Levin A, et al, "Chronic kidney disease as a global public health problem: Approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes", Kidney International, 2007 Aug; Vol 72, No 3, pp 247-59. Komenda P, Zalunardo N, Burnett S, Love J, Buller C, Taylor P, Duncan J, Djurdjev O, Levin A, "Conservative outpatient renoprotective protocol in patients with low GFR undergoing contrast angiography: a case series", Clinical and Experimental Nephrology, Japanese Society of Nephrology, Sept 2007 Vol 1l, No. 3, pp 209-13. Gutierrez O, Levin A, Andress D and Wolf M, "Prevalence and Severity of Disordered Mineral Metabolism in Blacks with Chronic Kidney Disease", accepted for publication KI, 2007. Levin A, Pate G, Shalansky S, Al-Shamari A, Webb J, Buller C, Humphries K, "N-acetylcysteine reduces urinary albumin excretion following contrast administration: evidence of biological effect", NDT South Africa Excerpts Edition, 2007 Nov; Vol 1, No. 4, pp 217-21.

NEUROLOGY

Barton, Dr. Jason J Dalrymple KA, Kingstone A, Barton JJS. Seeing trees OR seeing forests in simultanagnosia: attentional capture can be local or global. Neuropsychologia, 2007;45: 871-5. Fox CJ, Barton JJS. What is adapted in face adaptation? The neural representations of expression in the human visual system. Brain Res 2007; 1127: 80-9.

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Malcolm G, Barton JJS. "Sequence-agnosia" in Bálint’s syndrome: defects in visuotemporal processing after bilateral parietal damage. J Cogn Neurosci 2007: 19: 102-8. Manoach DS, Thakkar KN, Cain MS, Polli FE, Edelman JA, Fischl B, Barton JJS. Neural activity is modulated by trial history: A functional magnetic resonance imaging study of the effects of a previous antisaccade. J Neurosci 2007; 27: 1791-8. Barton JJS, Radcliffe N, Cherkasova MV, Edelman J. Scan patterns during the processing of facial identity in prosopagnosia. Exp Brain Res 2007; 181: 199-21. Barton JJS, Hefter RL, Cherkasova MV, Manoach DS. Investigations of face expertise in the social developmental disorders. Neurology 2007; 69:860-70. Greenzang C, Manoach DS, Goff D, Barton JJS. Task-switching in schizophrenia: intact active task reconfiguration and passive inhibition in an antisaccade paradigm. Exp Brain Res 2007; 181:493-502 Moon SY, Barton JJS, Mikulski S, Polli F, Cain MS, Hämäläinen MS, Manoach DS. Where left becomes right: a magnetoencephalographic study of sensorimotor transformation for antisaccades. Neuroimage 2007; 36: 1313-23. Manoach DS, Ketwaroo GA, Polli FE. Thakkar KN, Barton JJS, Goff DC, Fischl B, Vangel M, Tuch DS. Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia. Neuroimage 2007; 37: 599-610. Barton JJS, Hefter RL, Malcolm GL. Spatial processing in Bálint syndrome and prosopagnosia: a study of three patients. J NeuroOphthalmol 2007; 27:268-74. Polli FE, Barton JJS , Thakkar KN, Cain MS, Goff DC, Rauch SL, Manoach DS. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain 2007 Dec epub.

Briemberg, Dr. Hannah Briemberg HR. Neuromuscular Diseases in Pregnancy. Seminars in Neurology; 2007:27(5)460-466.

Cashman, Dr. Neil R Griffin JK, Terry LA, Jackman R, Yousefi M, Cashman NR. Decreased cell surface prion protein in mouse models of prion disease. Neuroreport 18:1-6, 2007. Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth DM, Griffin J, Cleveland DW, Cashman NR, Chakrabartty A. An immunological epitope selective for pathologically misfolded SOD1 in ALS. Nat Med 13 (6), 754-9, 2007. Li L, Coulthart MB, Balachandran A, Chakrabartty A, Cashman NR. Species barriers for chronic wasting disease by in vitro conversion of prion protein. Biochem Biophys Res Commun 364(4): 796-800, 2007.

Chapman, Dr. Kristine M Narayanaswami P, Chapman KM, Yang ML, Rutkove SB. Psoriatic arthritis-associated polyneuropathy: a report of three cases. J Clin Neuromuscul Dis. 2007 Sep; 9(1):248-51.

Curt, Dr. Armin E Egli D, Hausmann O, Schmid M, Boos N, Dietz V, Curt A. Lumbar spinal stenosis: Assessment of cauda equina involvement by electrophysiological recordings. J Neurol 2007; 254: 741-50. Fawcett JW, Curt A, Steeves JD, Coleman WP, Tuszynski M, Lammertse D, Bartlett P, Blight A, Dietz V, Ditunno J, Dobkin B, Havton L, Ellaway P, Fehlings M, Privat A, Grossman R, Guest J, Kleitman N, Nakamura M, Gaviria M, Short D. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP Panel: Spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 2007; 45: 190-205.

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Steeves JD, Lammertse D, Curt A, Fawcett J, Tuszynski M, Ditunno J, Ellaway P, Fehlings M, Guest J, Kleitman N, Bartlett P, Blight A, Dietz V, Dobkin B, Grossman R, Short D, Nakamura M, Coleman W, Gaviria M, Privat A. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP Panel: Clinical trial outcome measures. Spinal Cord 2007; 45: 206-221. Tuszynski M, Steeves JD, Fawcett J, Lammertse D, Kalichman M, Rask C, Curt A, Ditunno J, Fehlings M, Guest J, Ellaway P, Kleitman N, Bartlett P, Blight A, Dietz V, Dobkin B, Grossman R, Privat A. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP Panel: Clinical trial inclusion/exclusion criteria and ethics. Spinal Cord 2007; 45: 222-231. Lammertse D, Tuszynski M, Steeves JD, Curt A, Fawcett J, Rask C, Ditunno J, Fehlings M, Guest J, Ellaway P, Kleitman N, Blight A, Dobkin B, Grossman R, Katoh H, Privat A, Kalichman M. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the International Campaign for Cures of spinal cord Paralysis (ICCP) Panel: Clinical trial design. Spinal Cord 2007; 45: 232-242. Hedel vH, Curt A, Dietz V. Assessment of walking speed and distance in subjects with an incomplete spinal cord injury. Neurorehabilitation and Neural Repair 2007; 21: 295-301. Hedel vH, Murer C, Dietz V, Curt A. The amplitude of lower leg motor evoked potentials is a reliable measure when controlled for torque and motor task. J Neurol 2007; 254:1089-98. Hsieh J, Wolfe D, Connolly S, Townson A, Curt A, Blackmer J, Sequeira K, Aubut J. Spasticity after spinal cord injury: evidence-based review of current interventions. Topics in SCI Rehab 2007; 15: 81- 97. Wolfe DL, Hsieh J, Curt A, Teasell R. Neurological and Functional Outcomes Associated with SCI Rehabilitation. J Spinal Cord Injury Rehabilitation 2007; 15: 11-31. Hsieh J, Wolfe D, Miller W, Curt A. Spasticity Outcome Measures in Spinal Cord Injury: Tenable Tools - What's available, what's missing and what's needed? Spinal Cord 2007 (Oct 2; Epub). Wirth B, Hedel vH, Kometer B, Dietz V, Curt A. Changes in activity after a complete spinal cord injury as measured by the Spinal Cord Independence Measure II (SCIM II). Neurorehab Neural Repair 2007 (Aug 30; Epub). Gerber C, Blumenthal S, Curt A, Werner CM. Effect of selective experimental suprascapular nerve block on abduction and external rotation strength of the shoulder. Journal of Shoulder and Elbow Surgery 2007; 16: 815-820.

Devonshire, Dr. Virginia A Sayao AL, Devonshire V, Tremlett H. Longitudinal Follow-up of Benign MS at 20 years. Neurology. 2007 Feb 13;68(7):496-500.

Doudet, Dr. Doris J Sossi V, Holden JE, Topping GS, Camborde ML, Kornelsen R, McCormick S, Greene J, Studenov AR, Ruth TJ, Doudet DJ “In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD” J. Cereb. Blood Flow Metab. 27:1407-1415 (2007). Wong JT, Kim PT, Peacock JW, Yau TY, Mui AL, Sossi V, Doudet DJ, Ruth TJ, Parsons R, Verchere CB, Ong CJ " Pten haploinsufficiency promotes insulin hypersensitivity" Diabetologia 50:395-403 (2007) epub 2006.. Strome EM, Doudet DJ. Animal Models of Neurodegenerative Diseases: Insight from Imaging Studies". MIB march 9:186-195 (2007). Sossi V, Holden JE, Topping GS, Camborde ML, Kornelsen R, McCormick S, Greene J, Studenov AR, Ruth TJ, Doudet DJ "In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD" J. Cereb. Blood Flow Metab. 27:1407-1415 (2007) Strome EM, Zis AP, Doudet DJ "Electroconvulsive shock enhances striatal D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats" I J. Psychiat. Neurosci. 32:193-202 (2007).

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Cepeda I, Flores J, Cornfeldt M, O'Kusky J, Doudet DJ. "Human Retinal Pigment Epithelial Cell Implants Ameliorate Motor Deficits in Two Rat Models of Parkinson's Disease" J. Neuropath. Exp. Neurol. 66:576-584 (2007). Flores J, Cepeda I, Cornfeldt M, O'Kusky J, Doudet DJ. Characterization of Long Term Implants of Human Retinal Pigment Epithelial Cells Attached to Gelatin Microcarriers in a Rat Model of Parkinson's Disease" J. Neuropath. Exp. Neurol. 66:585-596 (2007) Doudet DJ. Neurodegenerative Diseases. Editorial - MIB 32:159-160 (2007).

Feldman, Dr. Howard H Li H, Wetten S, L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes M, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, Fornazzari L, Gauthier S, Goodgame N, Guzman D, Hammond S, Hollingworth P, Hsiung GYR, Johnson J, Kelly DD, Keren R, Kertesz A, King KS, Lovestone S, Loy English I, Matthews, P. Owen MJ, Plumpton M, Pryce Phillips W, Prinjha R, Gibson RA, Irizarry MC, Middleton LT, and Roses AD. Candidate Single Nucleotide Polymorphisms from a Genome-Wide Assocation Study of Alzheimer’s Disease. Archives of Neurology [Epub ahead of print Nov.12,2007]. Peters KR, Rockwood K, Black SE, Hogan DB, Gauthier SG, Loy-English I, Hisung G-Y R, Jacova C, Kertesz A, and Feldman HH. Neuropsychiatric symptom clusters and functional disability in cognitively-impaired-not-demented individuals. American Journal of Geriatric Psychiatry 2007 [Epub ahead of print Oct.10,2007]. Hallam BJ, Silverberg ND, LaMarre AK, Mackenzie IRA, and Feldman HH. Clinical presentation of prodromal frontotemporal dementia. American Journal of Alzheimer’s Disease & Other Dementias 2007;22(6):456-467. Jacova C, Kertesz A, Blair M, Fisk J, and Feldman HH. Neuropsychological testing and assessment for dementia. Alzheimer’s & Dementia 2007;3:299-317. Hsiung G-Y R, and Feldman HH (September 2007). GRN-Related Frontotemporal Dementia in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2007. Available at http://www.genetests.org. (peer-reviewed). Rademakers R, Baker M, Gass J, Adamson J, Huey E, Momeni P, Spina S, Coppola G, Karydas A, Stewart H, Johnson N, Hsiung G-Y, Kuntz K, Steinbart E, McCarty Wood E, Josephs K, Sorenson E, Womack K, Pickering-Brown SM, Lee VY, Schofield P, Ghetti B, Schellenberg GD, Beach TG, Mesulam M, Grafman J, Mackenzie I, Feldman HH, Bird T, Petersen R, Knopman D, Boeve B, Geschwind D, Miller B, Wzsolek Z, Lippa C, Bigio E, Dickson D, Graff-Radford N and Hutton M. An international initiative to study phenotypic variability associated with progranulin haploinsufficiency in patients with the common c.1477C>T (p.R493X) mutation. Lancet Neurology 2007;6(10):857-868. Dubois B *, Feldman HH *, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jacova C, Jicha G, Meguro K, Morris J, O’Brien J, Pasquier F, Robert P, Rossor M Salloway S, Stern Y, Visser PJ and Scheltens P. Research criteria for the diagnosis of Alzheimer’s disease: Revising of the NINCDS-ADRAD criteria. Lancet Neurology 2007; 6(8):734-746. (* co-first authors). Feldman HH, Ferris S, Winblad B, Sfikas N, Mancione L, He Y. Tekin S, Burns A, Cummings J, Del Ser T, Inzitari D, Orgogozo JM, Sauer H, Scheltens P, Scarpini E, Herrmann N, Farlow M, Potkin S, Charles HC, Fox NC, Lane R. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurology 2007 Jun;6(6):501-12. Rockwood K, Chertkow H and Feldman HH. Mild Cognitive Impairment: Canadian Journal of Neurological Sciences.2007; 34 (Suppl 1): S90-6. Feldman HH and Jacova C. Primary Prevention and Delay of Onset of Alzheimer Disease and Dementia. Canadian Journal of Neurological Sciences. 2007; 34 (Suppl 1): S90-6. Blair M, Kertesz, A, Davis-Faroque N, Hsiung G-Y R, Black SE, Bouchard RW, Gauthier S, Guzman DA, Hogan DB, Rockwood K, and Feldman H. Behavioural Measures in Frontotemporal Lobar Degeneration and Other Dementias: The utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study. Dementia and Geriatric Cognitive Disorders. 2007;23(6):406-415.

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Feldman HH, Lane R. Rivastigmine: A placebo-controlled trial of BID and TID regimens in patients with Alzheimer's disease. Journal of Neurology, Neurosurgery, & Psychiatry. 2007;78(10):1056-1063. Maia L, Mackenzie IRA, and Feldman HH. Clinical phenotypes of cerebral amyloid angiopathy. Journal of the Neurological Sciences. 2007;257(1-2):23-30. Rockwood K, King Moorhouse P, Song X, Macknight C, Gauthier S, Kertesz A, Montgomery P, Black S, Hogan DB, Guzman A, Bouchard R, Feldman HH. Disease progression in vascular cognitive impairment: Cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study. Journal of the Neurological Sciences 2007;252:106-12.

Hallam, Dr. Bradley J Hallam BJ, Silverberg ND, LaMarre AK, Mackenzie IRA, Feldman HH. Clinical presentation of prodromal frontotemporal dementia. Am J Alzheimer's Disease & Other Dementias 2007, (22)6, 456-67.

Hashimoto, Dr. Stanley A Ball, N., Cowan, B., Moore, G.W., and Hashimoto, S. Lobulus panniculitis at the site of glatiramer acetate injections for the treatment of relapsing remitting multiple sclerosis. A report of two cases. Journal of Cutaneous Pathology 2007: online.

Hooge, Dr. John P Boz C, Oger J, Gibbs E, Grossberg SE and the Neurologists of the UBC MS Clinic. Reduced effectiveness of long-term interferon-B treatment on relapses in neutralizing antibody positive multiple sclerosis patients: a Canadian multiple sclerosis clinic-based study. Multiple Sclerosis 2007; 13: 1127-1137

Hsiung, Dr. Ging-Yuek R Hsiung G-YR., Sadovnick AD. Genetics and dementia: Risk factors, diagnosis, and management. Alzheimer's and Dementia 2007:3(4);pp 418-427. Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu CE, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M. An international initiative to study phenotypic variability associated with progranuline haploinsufficiency in patients with the common c.1477C>T (p.R493X) mutation. Lancet Neurol. 2007 Oct;6(10):857-68. Hsiung G-Y R, Feldman HH (September 2007) GRN-Related Frontotemporal Dementia in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle, 1997-2007. Available at http://www.genetests.org Blair M, Kertesz A, Davis-Faroque N, Hsiung G-Y.R., Black S; Bouchard R; Gauthier S; Guzman DA; Hogan D; Rockwood K & Feldman H. Behavioural measures in frontotemporal lobar dementia and other dementias: The utility of the frontal behavioural inventory and the neuropsychiatric inventory in a national cohort study. Dementia & Geri Cog Dis 2007;23:306-315. Peters K, Rockwood K, Black S, Hogan D, Gauthier S; Loy-English I; Hsiung GR, Jacova C, Kertesz A, & Feldman H. Neuropsychiatric Symptom Clusters and Functional Disability in Cognitively-Impaired-Not-Demented Individuals. Am J Geriatr Psychiatry. 2007 Oct 10; [Epub ahead of print] PMID: 17928572.

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Illes, Dr. Judy Racine, E., Van der Loos, HZA, Illes, J. Internet marketing of neuroproducts: New practices and healthcare policy challenges. Cambridge Quarterly of Healthcare Ethics, Spring 2007, 16, 181-194. Illes, J., Rosen A., Greicius, M., Racine, E. Prospects for prediction: An ethics analysis of neuroimaging in Alzheimer’s Disease. Annals of the New York Academy of Sciences, 2007, 1097: 278-295. Eaton, M. and Illes, J. Anticipating ethical challenges in the commercialization of cognitive neuroscience. Nature Biotechnology, 2007, 25(4), 1-5. Singh, J., Hallmayer, J., Illes, J. Paradoxical relationships in the science of autism. Nature Review Neuroscience, 2007, 8, 153-160. Illes, J., Kirschen, M.P., Edwards, E., Stanford, L.R., Bandettini, P., Michael, D.B., Ford, P.J., Glover, G.H., Kulynych, J., Macklin R., Wolf, S.M., Grabowski, T., Seto B. Practical approaches to incidental findings in brain imaging research. Neurology. Under review. Racine, E., and Illes, J. Emerging ethical challenges in advanced neuroimaging research, Journal of Empirical Research on Human Research Ethics, 2007, 2(2), 1-10. Illes, J. Empirical neuroethics. EMBO/EBML J., 2007, 8, S57-S61. Greely H., Illes, J. Neuroscience-based lie detection: The urgent need for regulation. American Journal of Law and Medicine, 2007, 33, 377-431. Murphy, E.R., Illes, J. Neuroethics and psychiatry: New collaborations for emerging challenges, Psychiatric Annals, 2007, 37(12), 798-804. Eaton, M. and Illes, J. Commercializing cognitive neurotechnology - the ethical terrain. Nature Biotechnology, 2007, 25(4), 1-5. Racine, E., Waldman, S., Palmour, N., Risse, D., Illes, J. Currents of hope: Neurostimulation techniques in US and UK print media, Cambridge Quarterly of Healthcare Ethics, 2007, 16, 314-318.

Jacova, Dr. Claudia Dubois, B., Feldman, H., Jacova, C., DeKosky, S., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., Meguro, K., O'Brien, J., Pasquier, F., Robert, P., Rossor, M., Salloway, S., Stern, Y., Visser, P.J., and Scheltens, P. Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurology 2007 Aug;6(8):734-46. Peters, K.P., Hogan, D., Black, S., Gauthier, S., Rockwood, K., Loy-English, I., Hsiung, G.-Y.R., Jacova, C. and Feldman H.H. Neuropsychiatric symptom clusters and functional disability in Cognitively-Impaired-Not-Demented Individuals. American Journal of Geriatric Psychiatry Oct 20 2007 [Epub ahead of print]. Jacova, C., Kertesz, A., Blair, M., Fisk, J. and Feldman, H.H. Neuropsychological testing and assessment for dementia. Alzheimer's & Dementia 2007;3:299-317. Feldman, H. and Jacova, C. Primary prevention and delay of onset of AD/dementia. Canadian Journal of Neurological Sciences 2007;34 Suppl 1:S84-9.

Kim, Dr. Seung U Lee HJ, Kim KS, Kim EJ, Park IH, Kim SU. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS One 1/e156:1-14, 2007. Lee HJ Kim KS, Kim EJ, Lee KH, Choi HB, Park IH, Ko Y, Jeong SW, Kim SU. Brain transplantation of human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells 25, 211-224, 2007.

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Danks MK, K. Yoon KJ, BushRA, Remack JS, Wierdl M , Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS. Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma. Cancer Res 67:22-25, 2007. Kim SU. Genetically engineered human neural stem cells for brain repair in neurological diseases. Brain Dev 29:193-201, 2007. Dickson PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU, Ng CY, Gray JT, Aboody KS, Danks MK, Davidoff AM. Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma. J Pediatr Surg 42:48-53, 2007. Song YS, Lee HJ, Park IH, Kim WK, Ku JH, Kim SU. Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells. Int J Impot Res 19:378-385, 2007. Hara K, Matsukawa N, Yasuhara T, Xu L, Yu G, Maki M, Kawase T, Hess DC, Kim SU, Borlongan CV. Transplantation of post-mitotic human neuroteratocarcinoma-overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: in vitro evidence of expedited neuronal differentiation and GDNF secretion. J Neurosci Res 85:1240-1251, 2007. Kang BS, Ahn JY, Kim MK, Kim HJ, Kang L, Lim HC, Park KS, Lee JS, Seo JS, Cha CI, Kim SU, Park YJ, Kim M. Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin. Exp Mol Med 39:38-46, 2007. Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, Choi KS. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 67:6314-6324, 2007. Son YG, Kim EH, Kim JY, Kim SU, Kwon TK, Yoon AR, Yun CD, Choi KS. Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c- FLIP and surviving. Cancer Res 67: 8274-8284, 2007. Shimato S, Natsume A, Takeuchi H, Wakabayashi T, Fujii M, Ito M, Ito S, Park IH, Bang JH, Kim SU, Yoshida J. Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma. Gene Ther 15:1132-1142, 2007. Choi HB, Ryu JK, Kim SU, McLarnon JG. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci 27:4957-4968, 2007. Redmond DE Jr, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR Jr, Sidman RL, Snyder EY. From the Cover: Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci USA 104:12175-12180, 2007. Ishii J, Natsume A, Wakabayashi T, Takeuchi H, Hasegawa H, Kim SU, Yoshida J. The free-radical scavenger edaravone restores the differentiation of human neural precursor cells after radiation-induced oxidative stress. Neurosci Lett 423:225-30, 2007. Nagai A, Kim WK, Lee HJ, Jeong HS, Kim KS, Hong SH, Park IH, Kim SU. Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow.PLoS ONE. 2/e1272: 1-16, 2007. Lin D, Najbauer J, Salvaterra PM, Mamelak AN, Barish ME, Garcia E, Metz MZ, Kendall SE, Bowers M, Kateb B, Kim SU, Johnson M, Aboody KS. Novel method for visualizing and modeling the spatial distribution of neural stem cells within intracranial glioma. Neuroimage 37 Suppl 1:S18-26, 2007. Kim BG, Hwang TH, Kim EJ, Lee SI, Kim SU. Stem cell-based therapy in spinal cord injury. Cell Transplant 16:355-364, 2007. Kim M, Lee ST, Chu K, Kim SU: Stem cell-based cell therapy for Huntington disease: A review. Neuropathology, 2007 Dec 5 [Epub ahead of print]. Ryu MY, Kim DW, Arima K, Mouradian M, Kim SU, Lee G. Localization of CKII subunits in Lewy bodies of Parkinson's disease. J Neurol Sci, 2007 Dec 5 [Epub ahead of print].

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Oh HS, Lee MC, Kim HS, Lee JS, Lee JH, Kim MK, Woo YJ, Kim JH, Kim HI, Kim SU. Pathophysiological characteristics of balloon cells in cortical dysplasia. Childs Nerv Syst, 2007 Sept 26 [Epub ahead of print].

Krieger, Dr. Charles Ajami. B., Bennett, J., Krieger, C., Tetzlaff, W. and Rossi, F.M. (2007) Local self-renewal sustains CNS microglial maintenance and function throughout adult life. Nature, Neuroscience 10(12):1538-43. Petrik, M.S., Wilson, J.M.B, Grant, S.C., Blackband, S.J, Shan, X, Schulz, J.D, Singh, S, Krieger, C. and Shaw, C.A. (2007) Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits. Neuromolecular Medicine 9(3):216-29.

Leavitt, Dr. Blair R Wong D, Dwinnel M, Schulzer M, Nimmo M, Leavitt BR, and Spacey SD. Ataxia and the Role of Antigliadin Antibodies. Canadian Journal of Neurological Sciences. 2007 May;34(2)193-6. Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR. Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiology of Disease. 2007 Apr;26(1):189-200. Epub 2006 Dec 29. Butland SL, Devon RS, Huang Y, Mead CL, Meynert AM, Neal SJ, Lee SS, Wilkinson A, Yang GS, Yuen MM, Hayden MR, Holt RA, Leavitt BR*, Ouellette BF*. CAG-encoded polyglutamine length polymorphism in the human genome. BMC Genomics. 2007 May 22;8 (1):126 * Co-Senior Authors = contributed equally. Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RL, Olson JM, Bates GP, Jones L, Luthi-Carter R. Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics; 2007 16(15):1845-61. May 21; [Epub ahead of print] Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersen A, Bjorkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Testicular Degeneration in Huntington Disease. Neurobiology of Disease. 2007 26(3):512-20. [Epub 2007 Jan 27]. Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ. Proteomic Profiling of Plasma in Huntington's Disease Reveals Neuroinflammatory Activation and Biomarker Candidates. Journal of Proteome Research; 2007 6(7):2833-40. Jun 7; [Epub ahead of print]. Bjorkqvist M, Leavitt BR, Nielsen JE, Landwehrmeyer B, Ecker D, Mulder H, Brundin P, Petersen A. Cocaine- and amphetamine-regulated transcript is increased in Huntington disease. Movement Disorders; 2007 22(13):1952-4. Aug. 23; [Epub ahead of print].

McKeown, Dr. Martin J McKeown, Martin, Junning Li, X Huang, Mechelle Lewis, Seungshin Rhee, Young Truong and Jane Wang. Local Linear Discriminant Analysis (LLDA) for Group and Region of Interest (ROI)-based fMRI analysis. Neuroimage.. 2007 Sep 1;37(3):855-65. Huang, X., McKeown, MJ, Gerig, G. Gu, H. Lin, W. Lewis, M. Ford, S., Troster, A. Weingerger, D, Sytner, M. Asymmetric ventricular enlargement in Parkinson's disease. Movement Disorders 2007 Jun 22;22(11):1657-1660. Lewis, MM, Slagle, CG Smith, AB, Truong, Y., Bai, P. McKeown, MJ, Mailman, RB, Belger, A. Huang, X. Task specific influences of Parkinson's disease on the striato-thalamo-cortical and cerebello-thalamo-cortical motor circuitries, Neuroscience 2007 Jun 15;147(1):224-35.

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Murphy, Dr. Colleen B M Mehdiratta, C Murphy, A Al-Harthi, P Teal. Myocardial Infarction Following tPA for Acute Stroke. Canadian Journal of Neurological Sciences. 2007; 34(4): 417-20. J Kennedy, M Hill, K Ryckborst, M Eliasziw, A Demchuk, A Buchan for the FASTER Investigators. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomized controlled pilot trial. Neurology.The Lancet. Published online October 10, 2007 DOI:10.1016/S1474-4422(07)70250-8.

Oger, Dr. Joel Massart C, Gibassier J, Oger J, Le Page E, Edan G. Neutralizing antibodies to interferon beta in multiple sclerosis: analytical evaluation for validation of a cytopathic effect assay. Clin Chim Acta. 2007 Feb;377(1-2):185-91. Epub 2006 Sep 30. Erratum in: Clin Chim Acta. 2007 May 1;380(1-2):255. Gibbs E, Oger J. The IgG subclass-specificities of anti-IFNbeta antibodies change with time and differ between the IFNbeta products in relapsing remitting multiple sclerosis patients. J. Neuroimmunol.2007;190(1-2):146-150. Bar-Or A, Vollmer T, Antel J, Arnold DL, Bodner CA, Campagnolo D, Gianettoni J, Jalili F, Kachuck N, Lapierre Y, Niino M, Oger, J, Prive M, Rhodes S, Robinson WH, Shi FD, UtzPJ, Valone F, Weiner L, Steinman L, Garren H. Induction of Antigen-Specific Tolerance in Multiple Sclerosis After Immunization with DNA Encoding Myelin Basic Protein in a Randomized, Placebo-Controll Phase ½ Trial. Arch Neurol 2007; 64(10):1407-1410. Kister I, Herbert J, Swerdlow ML, Bergamaschi R, Piccolo G, Oger J. Occurrence of CNS demyelinating disease in patients with myasthenia gravis. Neurology. 2007 Apr 17;68(16):1326-7; author reply 1327. Goodin DS, Frohman EM, Hurwitz B, O'Connor PW, Oger J, Reder AT, Stevens JC. Neutralizing antibodies to interferon beta: assessment of their clinical and radiographic impact: an evidence report: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology.2007 Mar 27;68(13):977-84. Erratum in: Neurology. 2007 Aug 14;69(7):712. Boz C, Oger J, Gibbs, Grossberg SE; the Neurologists of the UBC MS Clinic. Reduced effectiveness of long-term interferon-(beta) treatment on relapses in neutralizing antibody-positive multiple sclerosis patients: a Canadian multiple sclerosis clinic-based study. Mult Scler. 2007 Nov;13(9):1127-1137.

Pelech, Dr. Steven Hoerndli, F.J., Pelech, S., Papassotiropoulos, A., & Gotz, J. Abeta treatment and P301L tau expression in an Alzheimer's disease tissue culture model act synergistically to promote aberrant cell cycle re- entry. Eur. J. Neurosci. 26:60-72 (2007). Oh, W.J., Rishi, V., Pelech, S.L., & Vinson, C. Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin. Carcinogenesis 28:2244-2252 (2007). Ha, S.D., Ng, D., Pelech, S.L., & Kim, S.O Critical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages.. J. Biol. Chem. 282:36230-36239 (2007).

Raymond, Dr. Lynn A Beglinger, L.J., Langbehn, D.R., Duff, K., Stierman, L., Black, D.W., Nehl, C., Anderson, K., Penziner, E., Paulsen, J.S.; the Huntington Study Group Investigators. (2007) Probability of obsessive and compulsive symptoms in Huntington's disease. Biological Psychiatry, 61:415-418 (PMID: 16839521). Fan, M.M.Y., Raymond, L.A. (2007) N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Progress in Neurobiology, 81:272-293 (PMID: 17188796). Fan, M.M.Y., Fernandes, H.B., Zhang, L.Y.J., Hayden, M.R., Raymond, L.A. (2007) Altered NMDA Receptor Trafficking in a YAC Transgenic Mouse Model of Huntington's Disease. J Neuroscience, 27: 3768-3779.

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Fernandes, H.B., Baimbridge, K.G., Church, J., Hayden, M.R., Raymond, L.A. (2007) Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease. Journal of Neuroscience, 27(50):13614-13623. Milnerwood, A.J., Raymond, L.A. (2007) Corticostriatal synaptic function in mouse models of Huntington's disease: Early effects of huntingtin repeat length and protein load. Journal of Physiology, 585(Pt 3):817-831. Johnson SA, Stout JC, Solomon AC, Langbehn DR, Aylward EH, Cruce CB, Ross CA, Nance M, Kayson E, Julian-Baros E, Hayden MR, Kieburtz K, Guttman M, Oakes D, Shoulson I, Beglinger L, Duff K, Penziner E, Paulsen JS; Predict-HD Investigators of the Huntington Study Group. (2007) Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease. Brain, 130(Pt 7):1732-1744. Langbehn DR, Paulsen JS; Huntington Study Group. (2007) Predictors of diagnosis in Huntington disease. Neurology, 15;68(20):1710-1717. Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Stout JC; Predict-HD Investigators of the Huntington Study Group. (2007) Psychiatric symptoms in Huntington's disease before diagnosis: the predict-HD study. Biol Psychiatry, 62(12):1341-1346. Solomon AC, Stout JC, Johnson SA, Langbehn DR, Aylward EH, Brandt J, Ross CA, Beglinger L, Hayden MR, Kieburtz K, Kayson E, Julian-Baros E, Duff K, Guttman M, Nance M, Oakes D, Shoulson I, Penziner E, Paulsen JS; Predict-HD investigators of the Huntington Study Group. (2007) Verbal episodic memory declines prior to diagnosis in Huntington's disease. Neuropsychologia, 45(8):1767-1776.

Rieckmann, Dr. Peter E Kumpfel T, Hoffmann LA, Pollmann W, Rieckmann P, Zettl UK, Kuhnbach R, Borasio GD, Voltz R. Palliative care in patients with severe multiple sclerosis: two case reports and a survey among German MS neurologists. Palliat Med. 21; 109-14, 2007. Buttmann M, Lorenz A, Weishaupt A, Rieckmann P. Atorvastatin partially prevents an inflammatory barrier breakdown of cultured human brain endothelial cells at a pharmacologically relevant concentration. J Neurochem. 102; 1001-8, 2007 Fischer M, Kress W, Reiners K, Rieckmann P.Orthostatic tremor in three brothers. J Neurol. Jul 31; [Epub ahead of print] 2007 Flachenecker P, Zettl UK, Götze U,Stuke K, Elias W, Eulitz M, Haas J, Pette M, Pitschnau-Michel D, Schimrigk S, Rieckmann P. MS-Register in Deutschland: Abschließende Ergebnisse der Pilotphase. Neurol. Rehab. 13; 193-200, 2007. Buttmann M, Merzyn C, Hofstetter HH, Rieckmann P. TRAIL, CXCL10 and CCL2 plasma levels during long-term interferon beta treatment of patients with multiple sclerosis correlate with flu-like adverse effects but do not predict therapeutic response. J. Neuroimmunol. 190; 170-76, 2007.

Ruth, Dr. Thomas J S Lapi, J Wilson, S McQuarrie, J Publicover, M Schueller, D Schyler, J Ressler, TJ Ruth. Measurement of cross sections production of 181-186Re isotopes from proton bombardment of natural tungsten. Appl. Radiat. Isotopes. 65:345-9 2007. DTT Yapp, TJ Ruth, MJ Adam, D Green, M Gleave. Non-invasive evaluation of tumor model for prostate cancer with 18F-EF5 and positron emission tomography. Brit. J. Urology International. 99:1154-60 (2007). V Sossi, JE Holden, G Topping, M-L Camborde, R Kornelsen, S McCormick, J Greene, A Studenov, TJ Ruth, DJ Doudet. In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD. JCBF 27:1407-15 (2007). JT Wong, PTW Kim, AL-F Mui, ST Chung, V Sossi, D Doudet, D Green, T Ruth, R Parsons, CB Verchere, CJ Ong. Pten haploinsufficiency promotes insulin hypersensitivity. Diabetologia, 50:395- 403. (2007).

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V Sossi, R de la Fuente-Fernández, M Schulzer, A Troiano, TJ Ruth, AJ Stoessl. Dopamine transporter relation to dopamine turnover in Parkinson's: a PET study. Ann. Neur. (2007); 62:468-74. CL Ferreira, S Lapi, J Steele, DE Green, TJ Ruth, MJ Adam, C Orvig. Cobalt-55 Complexes with Pendant Carbohydrates as Potential PET Imaging Agents. Appl. Radiat. Isot. 65: 1303-1308 (2007).

Sadovnick, Dr. Adele D Ness JN, Chabas D, Sadovnick AD, Pohl D, Banwell B, Weinstock-Guttman B. Clinical Features of Children and Adolescents with multiple sclerosis. Neurology Supplement, accepted September 2006. Herrera BM, Cader MZ, Dyment DA, Bell J, DeLuca GC, Willer CJ, Lincoln MR, Ramagopalan SV, Orton S, Chao MJ, Sadovnick AD, Ebers GC. Multiple sclerosis susceptibility and the X chromosome. Multiple Sclerosis (accepted December 2006). Ness JN, Chabas D, Sadovnick AD, Pohl D, Banwell B, Weinstock-Guttman B. Clinical Features of Children and Adolescents with multiple sclerosis. Neurology 2007; 68:s37-45. Herrera BM, Cader MZ, Dyment DA, Bell J, DeLuca GC, Willer CJ, Lincoln MR, Ramagopalan SV, Orton S, Chao MJ, Sadovnick AD, Ebers GC. Multiple sclerosis susceptibility and the X chromosome. Multiple Sclerosis 2007; 13;856-864. Sadovnick AD, Duquette P, Herrera B, Yee IML, Ebers GC. A Timing of Birth Effect on Multiple Sclerosis Clinical Phenotype. Neurology, 2007; 69:60-62. Ramagopalan SV, DeLuca GC, Morrison KM, Herrera BM, Dyment DA, Orton S, Bihoreau MT, Degenhardt A, Pugliatti M, Sadovnick AD, Sotgiu S, Ebers GC. No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis. J Neuroimmunol March 19 2007 (epub ahead of print). Herrera BM, Ramagopalan SV, Orton S, Chao MJ, Yee IML, Sadovnick AD, Ebers GC. Parental transmission of MS in a population-based Canadian cohort. Neurology. 2007 Jun 27; [Epub ahead of print]. Deluca GC, Ramagopalan SV, Cader MZ, Dyment DA, Herrera BM, Orten S, Degenhardt A, Pugliatti M, Sadovnick AD, Sotgiu S, Ebers GC. The role of hereditary spastic paraplegia related genes in multiple sclerosis : A study of disease susceptibility and clinical outcome. J Neurol. 2007 Apr 10; [Epub ahead of print]. Ramagopalan SV, Dyment DA, Herrera BM, Criscuoli M, Yee IM, Ebers GC, Sadovnick AD for the Canadian Collaborative Study Group. The Occurrence of Autoimmune Disease in Canadian Families with Multiple Sclerosis. Lancet Neurology 2007; 6:604-610. Jun 6; [Epub ahead of print]. Chao MJ, Barnardo MCM, Ramagopalan SV, Herrera BM, Lincoln MR, Dyment DA, Sadovnick AD, Ebers GC. Transmission of class I/II multi-locus MHC haplotypes and Multiple Sclerosis susceptibility. Hum Mol Genet. 2007 Jun 20; [Epub ahead of print] Hsiung G-YR, Sadovnick AD. Genetics and dementia eisk factors, diagnosis, and management. Recommendations from the Third Canadian Consensus Conference on Diagnosis and Treatment of Dementia. Alzheimer and Dementia 2007; 3:418-427. Ramagopalan SV, Morris AP, Dyment DA, Herrera BM, DeLuca GC, Lincoln MR, Orton SM, Chao MJ, Sadovnick AD, Ebers GC. The inheritance of resistance alleles in multiple sclerosis. PLoS Genetics 2007; 3: 1607-1613. DeLuca GC, Ramagopalan SV, Herrera BM,. Dyment DA, Monpetit A, Pugliatti M, Sadovnick AD, Esiri MM, Sotgiu S, Hudson TJ, Ebers GC. Multiple sclerosis severity is determined by alleles at the Locus: An extremes of outcome strategy. PNAS (Epub Dec 10 2007). Ramagopalan SV, Anderson S, Sadovnick AD, Ebers GC. Genomewide study of multiple sclerosis. N Engl J Med.2007; 357:2199-2200.

Spacey, Dr. Sian Wong D, Dwinnel M, Schulzer M, Nimmo M, Leavitt BR, Spacey SD. Ataxia and the role of antigliadin antibodies. Can J Neurol Sci. 2007 May;34(2):193-6.

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Stoessl, Dr. A J Postuma RB, Wolfson C, Rajput A, Stoessl AJ, Martin WRW, Suchowersky O, Chouinard S, Panisset M, Jog MS, Grimes DA, Marras C, Lang AE (2007). Is There Seasonal Variation in Risk of Parkinson's Disease? Movement Disorders 22: 1097-1101. Gunzler SA, Stoessl AJ, Egan RA, Weleber RG, Wang P, Nutt JG (2007). Joubert Syndrome presenting as a movement disorder in an adult. Movement Disorders 22: 262-264. Stoessl AJ (2007). Gene therapy for Parkinson's disease: early data. Lancet 369: 2056-2058 (invited editorial). Sossi V, de la Fuente-Fernandez R, Schulzer M, Troiano A, Ruth TJ, Stoessl AJ (2007). Dopamine transporter relation to dopamine turnover in Parkinson disease: a PET study. Annals of Neurology 62: 468-475. Stoessl AJ (2007). Positron emission tomography in premotor Parkinson's disease. Parkinsonism & Related Disorders 13: S421-S424.

Teal, Dr. Philip A Woolfenden AR, Wade NK, Tang P, Chalmers A, Reid G, Teal PA. Uveitis associated with Primary Angiitis of the Central Nervous System. Can J Neurol Sci. 2007; 34: 81-3. M Mehdiratta, C Murphy, A Al-Harthi, P Teal. Myocardial Infarction Following tPA for Acute Stroke. Canadian Journal of Neurological Sciences. 2007; 34(4): 417-20.

Traboulsee, Dr. Anthony Vavasour IM, Li DK, Laule C, Traboulsee AL, Moore GR, MacKay AL: Multi-parametric MR assessment of T1 black holes in multiple sclerosis: Evidence that myelin loss is not greater in hypointense versus isointense T1 lesions. Journal of Neurology 2007;12:1653-1659. Traboulsee A: MRI relapses have significant pathologic and clinical implications in multiple sclerosis. Journal of Neurological Sciences 2007;256(Suppl 1);S19-22. Zhao Y, Traboulsee A, Petkau J, Li D: Regression to the mean affects gadolinium enhancing lesion activity in relapsing-remitting multiple sclerosis: implications for clinical trial design. American Academy of Neurology (AAN) April 25-May 5, 2007, Boston, MA. Neurology 68(Suppl 1):A331, March 2007. Ebers G, Goodin D, Li D, Traboulsee A, Reder A, Konieczny A: The interferon beta-1b 16-year long-term follow-up study: predictive clinical and MRI markers. American Academy of Neurology (AAN) April 25-May 5, 2007, Boston, MA. Neurology 68(Suppl 1):A277, March 2007. Laule C, Vavasour IM, Madler B, Kolind SH, Sirrs SM, Brief EE, Traboulsee AL et al. MR evidence of long T2 water in pathological white matter. Journal Magnetic Resonance Imaging. Magnetic Resonance Imaging 2007:26(4):1117-1121. Vavasour IM, Li DK, Laule C, Traboulsee AL, Moore GR, MacKay AL: Multi-parametric MR assessment of T1 black holes in multiple sclerosis: Evidence that myelin loss is not greater in hypointense versus isointense T1 lesions. Journal of Neurology 2007:12:1653-1659. Laule C, Vavasour IM, Kolind SH, Traboulsee AL, Moore GR, Li DKB, MacKay A: Long T2 water in multiple sclerosis: What else can we learn from multi-echo T2 relaxation? Journal of Neurology 2007:11:1579-1587. Laule C, Vavasour IM, Kolind SH, Li DK, Traboulsee A, Moore GR, MacKay AL: Magnetic resonance imaging of myelin. Neurotherapeutics 2007:4(3):460-484.

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Tremlett, Dr. Helen L Sayao AL, Devonshire V, Tremlett H. Longitudinal Follow-up of Benign MS at 20 years. Neurology. 2007 Feb 13;68(7):496-500. Tremlett HL, Sayao AL, Devonshire V. Longitudinal follow-up of ‘benign’ multiple sclerosis at 20 years. Neurology 2007;69(9):938 (letter).

Wang, Dr. Yu Tian Xu W, Wong TP, Chéry N, Gaertner T, Wang YT and M Baudry, Calpain-Mediated mGluR1a Truncation: A Key Step in Excitotoxicity, Neuron 53, 399-412, 2007. Vestiska SM, G Ahmadian, W Ju, L Liu, MP Wymann, YT Wang. GABAA receptor-associated phophoionsitide 3-kinase is required for insulin-induced recruitment of post-synaptic GABAA receptors, Neuropharmacology, 52: 146-155, 2007. Peineau S, C Taghibiglou, C Bradley, TP Wong, L Liu, J Lu, E Lo, DC Wu, E Saule, T Bouschet, P Matthews, P Isaac, Z Bortolotto, YT Wang, G Collingridge, LTP inhibits LTD in the hippocampus via regulation via GSK3ß, Neuron 53: 703-717, 2007. Gerkin RC, PM Lau, D Nauen, YT Wang, GQ Bi, Modular competition driven by NMDA receptor subtypes in spike-timing-dependant plasticity, J Neurophys, 97:2852-2862, 2007. Liu Y, TP Wong, M Aarts, A Rooyakkers, L Liu, T Lai, DC Wu, J Lu, M Tymianski, AM Craig, YT Wang, NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo, J Neurosci, 27 (11):2846-2857, 2007. Metzler M, L Gan, TP Wong, L Liu, J Helm, J Georgiou, Y Wang, N Bissada, K Cheng, J Roder, YT Wang, M Hayden, NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1, J Neurosci, 27(9):2298-–2308, 2007. Wong TP, JG Howland, JM Robillard, Y Ge, W Yu, AK Titterness, K Brebner, L Liu, J Weinberg, BR Christie, AG Phillips, and YT Wang. Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment, Proc Natl Acad Sci, 104 (27): 11471-11476, 2007. Fox CJ, K Russell, AK Titterness, YT Wang, BR.Christie. Tyrosine phosphorylation of the GluR2 subunit is required for long-term depression of synaptic efficacy in young animals in vivo, Hippocampus 17:600-605, 2007 Wu Y, KF Chan, JH Eubanks, CG Ting Wong, MA Cortez, L Shen, CC Liu, JP Velazquez, YT Wang, Z Jia, O Carter Snead 3rd. Transgenic mice over-expressing GABABR1a receptors acquire an atypical absence epilepsy-like phenotype, Neurobiol Dis. 26(2):439-51, 2007. Hong C, A Hayashi, HS Sun, MP Belmares, C Cobey, T Phan, J Schweizer, MW Salter, YT Wang, RA Tasker, D Garman, J Rabinowitz, PS Lu, and M Tymianski. PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors, J. Neurosci., 27 (37):9901-9915, 2007.

Woolfenden, Dr. Andrew R A R Woolfenden, N K Wade, P Tang, A Chalmers, G Reid, P A Teal. Uveitis associated with Primary Angiitis of the Central Nervous System. Can J Neurol Sci. 2007;34 (1):81-3.

PHYSICAL MEDICINE & REHABILITATION

Anton, Dr. Hubert A Fawkes-Kirby T, Wheeler M, Anton HA, Miller WC, Townson AF. Clinical Correlates of Fatigue in Spinal Cord Injury. Spinal Cord advance online publication, April 3, 2007; oi:10.1038/sj.sc.3102053. Miller WC, Anton HA, Townson AF. Use of the CES-D in Persons with Spinal Cord Injury. Spinal Cord advance online publication, October 2, 2007; doi:10.1038/sj.sc.3102127.

Krassioukov, Dr. Andrei Krassioukov A.V., Karlsson, A.K., Wecht, J., Wuermser, L.A., Mathias, C., and Marino, R.

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Assessment Classification of Autonomic Dysfunction in spinal cord injury: rationale for inclusion in ASIA/ISCoS Standards. J. Rehab Res Development. 2007, 44(1):1-10. Ackery, A., Norenberg, M., and Krassioukov, A.V. Calcitonin Gene-Related Peptide Immunoreactivity in Chronic Human Spinal Cord Injury. Spinal Cord, 2007, On line Feb 2007. Brakett, N.L., Ibrahim, E., Krassioukov, A.V., and Lynne, C. Systemic naloxone infusion may trigger spasticity in patients with spinal cord injury: case series. J Spinal Cord Med. 2007;30:29-32. Brackett, N.L., E. Ibrahim, Krassioukov, A.V., and Lynne, C.M. Systemic naloxone infusion may trigger spasticity in patients with spinal cord injury: case series. J Spinal Cord Med. 2007;30 (3):272-5. Hol, A., Eng, J.J., Miller, W.C., Sproule, S. and Krassioukov A.V. Reliability and validity of the six-minute arm test for the evaluation of cardiovascular fitness in individuals with spinal cord injury. Arch Phys Med Rehabil. 2007 Apr;88(4):489-95. Krassioukov A.V., Karlsson, A.K., Wecht, J.M., Wuermser, L.A., Mathias, C.J., and Marino, R.J. Assessment of autonomic dysfunctions following spinal cord injury: rationale for additions to international standards for neurological assessment. J. Rehab Res Development. 2007, 44(1):1-10. Ackery, A.D., Norenberg, M.D., and Krassioukov, A.V. Calcitonin Gene-Related Peptide Immunoreactivity in Chronic Human Spinal Cord Injury. Spinal Cord 45(10):678-86. 2007. Ekland, M., Krassioukov, A.V., McBride, K., and Elliott, S. Incidence of Autonomic Dysreflexia and Silent Autonomic Dysreflexia In Men With SCI Undergoing Sperm Retrieval: Implications For Clinical Practice. J Sp Cord Med. 30; 43-50, 2007. Tuli, S., Tuli, J., Coleman, WP., Geisler, F.H., and Krassioukov, A.V. Hemodynamic parameters and timing of surgical decompression in acute cervical spinal cord injury. J Sp Cord Med. 30; 25-33. 2007. Tarasova, O., A. Borovik, D. Tsvirkoun, V. Lebedev, J. Steeves, and A. Krassioukov. Microgravity induced orthostatic hypotension and effect of transcranial electrical stimulation. Aviat Space Environ Med, 78(11):1023-8. 2007. Claydon V and A. Krassioukov. Clinical correlatates of frequency analyses of cardiovascular control after spinal cord injury. Am J Physiol Heart Circ Physiol. 2007 Nov 16; [Epub ahead of print]. Warburton, D.ER., Eng, J., Krassioukov, A.V., Sproule, S. Cardiovascular Health and Exercise Following Spinal Cord Injury. Top Spinal Cord Inj Rehabil. 13(1); 98-122. 2007. Ashe, M., Craven, C., Eng, J., and Krassioukov, A.V. Prevention and treatment of Bone loss after Spinal Cord Injury: a systematic review. Top Spinal Cord Inj Rehabil. 13(1); 123-145. 2007

Townson, Dr. Andrea F Fawkes-Kirby TM, Wheeler MA, Anton HA, Miller WC, Townson AF, Weeks CA. Clinical correlates of fatigue in spinal cord injury. Spinal Cord. 2007 Apr 3; [Epub ahead of print].

Yassi, Dr. Annalee Yassi A, Lockhart K, Copes R, Kerr M, Corbiere M, Bryce EA. Determinants of healthcare workers compliance with infection control procedures in healthcare. Healthcare Quarterly. 2007 Jan;10(1):44- 52. Ouellette V, Badii M, Lockhart K, Yassi A. Worker satisfaction with a workplace injury prevention and return-to-work program in a large Canadian hospital: the importance of an integrated approach. Work. 2007; 28(2): 175-181 Spiegel JM, Gonzalez M, Cabrera GJ, Catasus S, Vidal C, Yassi A. Promoting health in response to global tourism expansion in Cuba. Health Promotion International. 2007 Dec 14; [Epub ahead of print] Bonet M, Spiegel JM, Ibarra AM, Kouri G, Pintre A, Yassi A. An integrated ecosystem approach for sustainable prevention and control of dengue in Central Havana. International Journal of Occupational and Environmental Health. 2007 Apr-Jun;13(2):188-94. Spiegel JB, Yassi A. Theatre of Alliances? Role-play, Representation and Ecohealth in Ecuador. Theatre Topics. 17(2)P: 129-140, 2007. Alamgir H, Swinkels H, Yu S, Yassi A. Occupational injury among cooks and food service workers in the healthcare sector. American Journal of Industrial Medicine. 2007 Jun 7;50(7):528-535.

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Alamgir H, Cvitkovich Y, Yu S, Yassi A. Work-related injury among direct care occupations in British Columbia, Canada. Occupational and Environmental Medicine. 2007 Nov;64(11):769-75. Epub 2007 May 23. Spiegel JM, Bonet M, Ibarra AM, Pagliccia N, Ouellette V, Yassi A. Social and environmental determinants of Aedes aegypti infestation in Central Havana: Results of a case-control study nested in an integrated dengue surveillance program in Cuba. Tropical Medicine and International Health. 2007 12(4):503-510. Craib KJ, Hackett G, Back C, Cvitkovich Y, Yassi A. Injury rates, predictors of workplace injuries, and results of an intervention program among community health workers. Public Health Nurse. 2007 Mar-Apr;24(2):121-31. Brodkin E, Copes R, Mattman A, Kennedy J, Kling R, Yassi A. Lead and mercury poisoning - still a concern? Canadian Medical Association Journal. 2007 Jan; 176(1):59-63.

RESPIRATORY MEDICINE

Ayas, Dr. Najib T Alajmi M, Mulgrew A, Fox J, Davidson W, Schulzer S, Mak E, Fleetham J, Ayas NT. The Impact of Continuous Positive Airway Pressure (CPAP) Therapy on Blood Pressure (BP) in Patients with Obstructive Sleep Apnea (OSA): A Meta-analysis of Randomized Controlled Trials. Lung 2007. 185: 67-72. Mulgrew AT, Cheema R, Fleetham J, CF Ryan, Ayas NT. Efficacy and Patient Satisfaction with Auto-adjusting with variable Expiratory Pressure vs. Standard CPAP: A Randomized Cross-over Trial. Sleep and Breathing 2007. 11:31-7. Ayas NT, Norena M, Wong H, Chittock D, Dodek PM. Pneumothorax after central venous catheter placement in the ICU: Impact of month of year and week of month. Quality and Safety in Healthcare 2007. 16:252-255. Mulgrew AT, Fox N, Ayas NT, Ryan CF. Diagnosis and initial management of obstructive sleep apnea without polysomnography: a randomized validation study. Annals of Internal Medicine 2007. 146:157-166. Kwiatkowska M, Atkins MS, Ayas NT, Ryan CF. Knowledge-based data analysis: First steps towards the creation of clinical prediction rules, using a new typically measure. IEEE Trans Inf Technol Biomed. 2007. 11(6):651-60.

Bai, Dr. Tony R McWhinnie R, Pechkovsky DV, Zhou D, Lane D, Halayko AJ, Knight DA, Bai TR. Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 292:L278-L286. 2007. An SS, Bai TR, Bates JHT, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PSP, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Review. European Respiratory Journal. Accepted for publication 2007.

UBC Department of Medicine Page 248 Annual Report 2007

Boyd, Dr. John Chiho Tokunga, Ryon Bateman, John Boyd, Yingjin Wang, James Russell and Keith Walley. "Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia: Critical Care Medicine. 35.5 (May, 2007): 1341-1347.

Brauer, Dr. Michael *Marshall JD. Nethery E, Brauer M. Within-urban variability in ambient air pollution: Comparison of estimation methods. Accepted, Atmospheric Environment. August 10, 2007. http://dx.doi.org/10.1016/j.atmosenv.2007.08.012 *Barn P, Larson T, Noullett M, Kennedy S, Copes R, Brauer M. Infiltration of forest fire and resential wood smoke: an evaluation of air cleaner effectiveness. Accepted, Journal of Exposure Science and Environmental Epidemiology. October 25, 2007. http://www.nature.com/jes/journal/vaop/ncurrent/abs/7500640a.html *Nethery E, Leckie S, Teschke K, Brauer M. From measures to models: An evaluation of air pollution exposure assessment for epidemiologic studies of pregnant women. Accepted, Occupational and Environmental Medicine, November 22, 2007. http://oem.bmj.com/cgi/rapidpdf/oem.2007.035337v1 Ainslie B, Steyn DG, Su J, Buzzelli M, Brauer M, Larson TV, Rucker M. A Source Area Model Incorporating Simplified Atmospheric Dispersion and Advection at Fine Scale for Population Air Pollutant Exposure Assessment. Accepted, Atmospheric Environment. December 5, 2007. http://dx.doi.org/10.1016/j.atmosenv.2007.12.021. Naeher LP, Smith KR, Brauer M, Kalman DA, Koenig JQ, Lipsett M, Zelikoff JT. Woodsmoke health effects: A review. Inhalation Toxicology. 2007; 19:67-106. *Henderson SB, Beckerman B, Jerrett M, Brauer M. Application of land use regression to estimate ambient concentrations of traffic-related NOX and fine particulate matter. Environmental Science and Technology. 2007; 41 (7):2422 -2428. Larson T, Su J, Baribeau A-M, Buzzelli M, Setton E, Brauer M. A Spatial Model of Urban Winter Woodsmoke Concentrations. Environmental Science and Technology. 2007; 41 (7): 2429 -2436 Brauer M, Hoek G, Smit J, de Jongste JC, Postma DS, Gerritsen J, Kerkhof M, Brunekreef B. Air Pollution and the Development of Asthma, Allergy and Respiratory Infections in a Birth Cohort. European Respiratory Journal. 2007; 29: 879-888. Su JG, Larson T, Baribeau A-M, Brauer M, Rensing M, Buzzelli M. Spatial modeling for air pollution monitoring network design: Example of residential woodsmoke. Journal of the Air and Waste Management Association. 2007; 57(8):893-900.

Carlsten, Dr. Christopher Carlsten C, DeRoos AJ, Kaufman J, Checkoway H, Wener M, Seixas N. Cell Markers, Cytokines and Immune Parameters in Cement Mason Apprentices. Arthritis and Rheumatism 2007;57:147-153. Carlsten C, Kaufman JD, Peretz A, Trenga CA, Sheppard L, Sullivan JH. Coagulation Markers in Healthy Human Subjects Exposed to Diesel Exhaust. Thrombosis Research 2007; 120(6):849-55.2007 Carlsten C, Aitken ML, and Hallstrand TS. Safety of Induced Sputum after Exercise Challenge in Asthma. Chest 2007;131:1339-45. Carlsten C, Hunt S. Stress, Redeployed. JAMA 2007: 298:18-19.

Cohen, Dr. Richard D Cohen RD. Accessible health care. Canadian Medical Association Journal 2007; 176: 209.

Cook, Dr. Victoria J Victoria J. Cook, MD; Sumi J. Sun, MPH; Jane Tapia, BSN; Stephen Q. Muth; D. Fermin Arguello, MD, MPH; Bryan L. Lewis, MPH; Richard B. Rothenberg, MD; Peter D. McElroy, PhD, MPH; and the Network Analysis Project Team*. Transmission network analysis in Tuberculosis contact investigations. Journal of Infectious Diseases 2007:196;1517-1527.

UBC Department of Medicine Page 249 Annual Report 2007

Daley, Dr. Denise Daley D, Morgan W, Willis J, Lewis S, Elston RC, Markowitz SD, Wiesner G: Is TGFBR1*6A susceptibility allele in familial colorectal neoplasia?: Cancer Epidemiology Biomarkers and Prevention: 16(5)1-3 2007. Begin P, Tremblay K, Daley D, Lemire M, Claveau S, Salasse C, Kacel S, Montpetit A, Becker A, Kozyrskyj AL, Hudson TJ, Laprise C: Association of Urokinase-type plasminogen activator with asthma: American Journal of Respiratory and Critical Care Medicine, Mar 15, 2007.

Duronio, Dr. Vincent Scott, A., Cook, J.L., Hart, D.A., Walker, D.C., Duronio, V., Khan, K.M. Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats. Arthritis Rheum. 56:871-81 (2007). Lian, O., Scott, A., Duronio, V., Khan, K. and Bahr, R. Excessive apoptosis in patellar tendinopathy in athletes. Am. J. Sports Medicine. 35: 605-11 (2007). Ong, C.J., Ming-Lum, A., Nodwell, M., Ghanipour, A., Yang, L., Williams, D.E., Kim, J., Demirjian, L., Qasimi, P., Ruschmann, J., Cao, L.P., Ma, K., Chung, S.W., Duronio, V., Andersen, R.J., Krystal, G., Mui, A.L. Small molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood. 110:1942-9 (2007). Wang, S.W., Parhar, K., Chiu, K.J., Tran, A., Gangoiti, P., Kong, J., Gonzalez, M., Salh, B., Duronio, V., Steinbrecher, U.P., Gomez-Munoz, A. Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway. Cell Signalling. 19: 1772-83 (2007). Behzad, H., Jamil, S., Denny, T.A., and Duronio, V. Cytokine-mediated FOXO3a phosphorylation suppresses FasL expression in hemopoietic cell lines. Investigation of the role of Fas in apoptosis due to cytokine starvation. Cytokine 38: 74-83 (2007). Germain, M. and Duronio, V. The amino terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function. J. Biol. Chem. 282: 32233 - 32242 (2007).

Fitzgerald, Dr. J. Mark Aaron S, FitzGerald JM. Tiotropium in Combination with Placebo, Salmeterol, or Fluticasone/Salmeterol for Chronic Obstructive Pulmonary Disease: A Randomized Trial. Annals of Internal Med. 2007; 146: 545 - 555. Adebi S, Harder CS, FitzGerald JM, Elwood RK, Marra F. Fluoro quinolones for the treatment of pulmonary tuberculosis: a systematic review. Drugs. 2007 67;2077-2099. FitzGerald JM, Haddon JM, Bradley-Kennedy C, Kuramoto L, Ford GT. Resource use study in COPD (RUSIC): a prospective study to quantify the effects of COPD exacerbations on health care resource use among COPD patients. Can Respir J. 2007 14:145-152. Habib K, Vedal S. Champion PC, FitzGerald JM. The role of pH monitoring in the assessment of patients with asthma and chronic cough. Canadian J of Gastroenterology. 2007;21: 159-163. McIvor RA, Boulet Louis- Philippe, FitzGerald JM, Zimmerman S, Chapman K. Asthma control in Canada: no improvement since we last looked in 1999. Can Family Physician. 2007;53:672-77. Marra F, Marra C, Bruchet N, Richardson K, Moadebi S, Elwood RK, FitzGerald JM. Adverse Drug Reactions Associated with First-Line Anti-Tuberculosis Drug Regimens.Int Journal of Tuberculosis and Lung Disease 2007;11: 909-914. Moran-Mendoza O, Marion S, Elwood K, Patrick DM, FitzGerald JM. Tuberculin skin test size and risk of tuberculosis development: a large population-based study in contacts. Int Journal of Tuberculosis and Lung Disease 2007; 11: 1014-1020. Dennis RJ, Solarte I, FitzGerald JM. Asthma. BMJ Clinical Evidence 2007; 07: 1501-1528. Alvarez GG, FitzGerald JM. A systematic review of the psychological risk factor associated with near fatal asthma or fatal asthma. Respiration. 2007;2: 228-236.

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Yassi A, Lockart K, Copes R, Kerr M, Corbiere M, Bryce E, Danyluk Q, Keen d, Yu S, Kidd C, Fitzgerald M, Thiessen R, Gamage B, Patrick D, Bigelow P, Saunders S and the SARS Study team. Determinants of health care workers compliance with infection control procedures. Health Q. 2007; 10:44-52. Cook V, Sun S, Tapia J, Lewis B; Munth S Arguello F, Rothenberg R, McElroy,P. and the Network Analysis Project Team*. Enhancing Tuberculosis Control with Transmission Network Analysis: the importance of place of residence. J Infect Dis, 2007; 96:1517-1527. Poureslami IM, Rootman I, Balka E, Devarakonda R, Hatch J, FitzGerald JM. A Systematic Review of Asthma and Health Literacy: A Cultural-Ethnic Perspective in Canada. MedGenMed 2007;9: 40. Bahadori K, Fitzgerald JM. Risk factors of hospitalization and readmission of patients with COPD exacerbation -systematic review. International Journal of COPD 2007; 2:241-251. Cohen RD, Bowie W, Enns R, Flint J, FitzgGerald JM. Pulmonary Actinomycosis complicating infliximab therapy for Crohn’s disease. Thorax 2007;16: 1013-1014. CK Chan, F Maltais, C Sigouin, JM Haddon, GT Ford, on behalf of the SAFE Study Group. A randomized controlled trial to assess the efficacy of tiotropium in Canadian patients with chronic obstructive pulmonary disease. Can Resp J 2007, 14; 8: 465-472. Fitzgerald JM, Wedzicha W. Pulmonary Puzzles. Thorax. 2007;62:381. Elwood K, FitzGerald JM. Bacille Calmette-Guerin (BCG) vaccination in Canada. Canadian Tuberculosis Standards; 6th Edition Editors. Long R. Ellis E. 2007. Balka E, Doyle-Waters M, Leecznarowicz D, FitzGerald JM. Technology, governance and patient safety: systems issues in technology and patient safety. Int J Med Inform. 2007 Jun;76:S1:35-47.

Levy, Dr. Robert D Kim WD, Ling SH, Coxson HO, English JC, Levy RD, Pare PD, Hogg JC. The association between small airway disease and emphysema phenotypes in chronic obstructive pulmonary disease. Chest 2007; 131: 1372-1378. Zhu G, Warren L, Aponte J, Gulsvik A, Bakke P, Agusti A, Calverley PMA, Donner CF, Levy RD, Make BJ, Paré PD, Rennard SI, Vestbo J, Wouters EFM, Anderson WH, Lomas DA, Silverman EK, Pillai SG. Polymorphisms in SERPINE2 are Associated with Chronic Obstructive Pulmonary Disease in Two Large Populations. Am J Respir Crit Care Med. 2007 Am J Respir Crit Care Med 176: 167-173. Ksienski D, Malhotra S, Walker B, Levy RD. Chest pain and cough in a 33-year-old postpartum woman. Chest 2007; 132:1389-92. Mathur S, MacIntyre DL, Forster BB, Road JD, Levy RD, Reid WD. Preservation of eccentric torque of the knee extensors and flexors in people with COPD. J Cardiopulmonary Rehab 2007; 27: 411-416.

Man, Dr. S. F. P Sin DD, Man SF. Systemic inflammation and mortality in chronic obstructive pulmonary disease. Can. J. Physiol. Pharmacol. 2007; 85: 141-7. Review. Sin DD, Wong E, Mayers I, Lien DC, Feeny D, Cheung H, Gan WQ, Man SF. Effects of nocturnal non-invasive mechanical ventilation on heart rate variability of patients with advanced chronic obstructive pulmonary disease. Chest 2007; 131: 156-63. Sin DD, Man SF. Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients? Curr Opin. Pulm. Med. 2007; 13: 90-7. Review. Ben-Zaken Cohen S, Pare PD, Man SF, Sin DD. The growing burden of chronic obstructive pulmonary disease and lung cancer in women: Examining sex differences in cigarette smoke metabolism. Am. J. Respir. Crit. Care Med. 2007; 176:113-20. Review. Sin DD, Leung R, Gan WQ, Man SF. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study. BMC Pulm Med. 2007.7:13.

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McWilliams, Dr. Annette M Chen J, Lam S, Pilon A, McWilliams A, Melby J, Szabo E. The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):577-83. Yuan R, Mayo JR, Hogg JC, et al. The effects of radiation dose and computed tomography manufacturer on measurements of lung densitometry. Chest. 2007 August:132;617-623. [Epub ahead of print]. Kennedy TC, McWilliams A, Edell E, et al. Bronchial Intraepithelial Neoplasia/Early Central Airways Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition). Chest. September 2007:132(3 suppl);221S-233S. Jonsson S, Varella-Garcia M, Miller Y, et al. Chromosomal Aneusomy in Bronchial High Grade Lesions is Associated with Invasive Lung Cancer. Am J Respir Crit Care Med. 2007 November 7 [Epub ahead of print]. Chen J, Lam S, Pilon A, McWilliams A, MacAulay C, Szabo E. Higher Levels of the Anti-inflammatory Protein CC10 are Associated with Improvement in Bronchial Dysplasia and Sputum Cytometric Assessment in Individuals at High Risk for Lung Cancer. Clin Can Res. Godoy MCB, Cooperberg P, Maizlin Z, et al. Detection Sensitivity of a commercial Lung Nodule CAD System in a Series of Pathologically Proven Lung Cancers. J Thorac Imaging.

Pare, Dr. Peter D Tanaka G, Sandford AJ, Burkett K, Connett JE, Anthonisen NR, Paré PD, He JQ. Tumour necrosis factor and lymphotoxin A polymorphisms and lung function in smokers. Eur Respir J. 2007 Jan;29(1):34-41. Epub 2006 Sep 13. Zhang X, Mahmudi-Azer S, Connett JE, Anthonisen NR, He JQ, Paré PD, Sandford AJ. Association of Hck genetic polymorphisms with gene expression and COPD. Hum Genet. 2007 Jan;120(5):681-690. Epub 2006 Sep 26. Ogawa E, Ruan J, Connett JE, Anthonisen NR, Paré PD, Sandford AJ. Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers. Respir Med. 2007 May;101(5):938-43. Tebbutt SJ, James A, Paré, PD. Single Nucleotide Polymorphisms & Lung Disease: Clinical Implications. CHEST 2007 Apr;131(4):1216-23. Dai JM, Kuo KH, Leo JM, Paré PD, van Breemen C, Lee CH. Acetylcholine-Induced Asynchronous Calcium Waves in Intact Human Bronchial Muscle Bundle. Am J Respir Cell Mol Biol. 2007 May;36(5):600-8. Epub Dec 14, 2006. An SS, Bai TR, Bates JHT, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PSP, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur. Respir. J. 2007 May;29(5):834-60. Kim WD, Ling SH, Coxson HO, English JC, Yee J, Levy RD, Paré PD, Hogg JC. The Association Between Small Airway Obstruction and Emphysema Phenotypes in Chronic Obstructive Pulmonary Disease. Chest. 2007 May;131(5):1372-8. Epub 2007 Feb 22. Zhang XZ, Paré PD, Sandford AJ. PMN degranulation in relation to CD63 expression and genetic polymorphisms in healthy individuals and COPD patients. Int J Mol Med. 2007 May;19(5):817-22. Ben-Zaken CS, Paré PD, Man SF, Sin DD. COPD and Lung Cancer in Women: Examining SexDifferences in Cigarette Smoke Metabolism. : Am J Respir Crit Care Med 2007 Jul 15;176(2):113-20 Epub 2007 Apr 5.

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Ali F, Chin L, Paré PD, Seow CY. Mechanism of partial adaptation in airway smooth muscle after a step change in length.J Appl Physiol. 2007 Aug;103(2):569-77. Hogg JC, Chu FS, Tan WC, Sin DD, Patel SA, Paré PD, Martinez FJ, Rogers RM, Make BJ, Criner GJ, Cherniack RM, Sharafkhaneh A, Luketich JD, Coxson HO, Elliott WM, Sciurba FC. Survival Following Lung Volume Reduction in COPD: Insights From Small Airway Pathology. Am J Respir Crit Care Med. 2007 Sep1;176(5):454-9. Yuan R, Mayo JR, Hogg JC, Paré PD, McWilliams AM, Lam S, Coxson HO. The Effects of Radiation Dose and Computed Tomography Manufacturer on Measurements of Lung Densitometry. Chest 2007 Aug;132(2)617-23. Epub 2007 Jun 15. Zhang X, He JQ, Ding L, Paré PD, Sandford AJ. Promoter polymorphism and expression of beta-arrestin 2 in neutrophils. Clin Chim Acta. 2007 Oct;385(1-2):79-80. Seow CY, Paré PD. Ultrastructural basis of airway smooth muscle contraction. Can J Physiol Pharmacol. 2007 Jul;85(7):659-665. Paré PD, McParland BE, Seow CY. Structural basis for exaggerated airway narrowing.Can J Physiol Pharmacol. 2007 Jul;85(7):653-658. Ip K, Sobieszek A, Solomon D, Jaio Y, Paré PD, and Seow CY. Physical integrity of smooth muscle myosin filaments is enhanced by phosphorylation of the regulatory myosin light chain. Cellular Physiology and Biochemistry, 20(5): 649-658, 2007. Wang IM, Stepaniants S, Boie Y, Mortimer JR, Kennedy B, Elliott M, Hayashi S, Loy L, Coulter S, Cervino S, Harris J, Thornton M, Raubertas R, Roberts C, Hogg JC, Crackower M, O'Neill G, Paré PD. Gene Expression Profiling in Patients with Chronic Obstructive Pulmonary Disease and Lung Cancer.Am J Respir Crit Care Med. 2007 Nov 1; [Epub ahead of print]. Sin DD, Cohen SB, Day A, Coxson H, Paré PD. Understanding the Biological Differences in Susceptibility to Chronic Obstructive Pulmonary Disease between Men and Women. Proc Am Thorac Soc. 2007 Dec;4(8):671-4.

Road, Dr. Jeremy Guenette JA, Witt JD, MMacKenzie DC, Road JD, Sheel AW. Respiratory mechanics during exercise in endurance trained men and women. J. Physiol. 581.3:1309-1322, 3 2007. Aaron SD, Vandemnheenm KL, Ferguson DF, Maltais F, Road J et al. Tiotropium in combination with placebo, Salmeterol, or Fluticasone-Salmeterol for treatment of chronic obstructive pulmonary disease. Ann. Intern. Med. 146:545-555, 2007. O'Donnell DE, Aaron S, Bourbeau J, Hernandez P, Road J et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease - 2007 update. Can. Respir. J. 14(suppl B):5B-32B, 2007. Mathur S, MacIntyre DL, Forster BB, Levy RD, Road JD, Reid WD. Preservation of eccentric torque of the knee extensors and flexors in people with COPD. Journal of Cardiopulmonary Rehabilitation 27(6):411-6, 2007.

Ryan, Dr. Francis (Frank) C Mulgrew A, Fox N, Ayas N, Ryan CF. An algorithm for diagnosis and initial management of obstructive sleep apnea without polysomnography: a validation study. Ann Intern Med In Print February 2007.

Sandford, Dr. Andrew J Zhang W, Zhang X, Qiu D, Sandford A, Tan WC. IL-4 receptor genetic polymorphisms and asthma in Asian populations. Respir. Med. 2007;101:186-190. Tanaka G, Sandford AJ, Burkett K, Connett JE, Anthonisen NR, Paré PD, He J-Q. Tumor necrosis factor and lymphotoxin A polymorphisms and lung function in smokers. Eur. Respir. J. 2007;29:34-41. Zhang X, Mahmudi-Azer S, Connett JE, Anthonisen NR, He J-Q, Paré PD, Sandford AJ. Association of Hck genetic polymorphisms with gene expression and COPD. Hum. Genet. 2007;120:681-690.

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Zhang XZ, Paré PD, Sandford AJ. PMN degranulation in relation to CD63 expression and genetic polymorphisms in healthy individuals and COPD patients. Int. J. Mol. Med. 2007;19:817-822. He J-Q, Shumansky K, Zhang X, Connett JE, Anthonisen NR, Sandford AJ. Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Eur. Respir. J. 2007 Mar 1. Epub ahead of print. Zhang X, He J-Q, Ding L, Paré PD, Sandford AJ. Promoter polymorphism and expression of -arrestin 2 in neutrophils. Clin. Chim. Acta. 2007 Jul 31. Epub ahead of print.

Sin, Dr. Donald D Sin DD* and Man SFP. Systemic inflammation and mortality in chronic obstructive pulmonary disease. Canadian Journal of Physiology and Pharmacolog 2007;85:141-7. Sin DD* and Man SFP. Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in COPD patients? Current Opinion in Pulmonary Medicine 2007 Mar;13(2):90-7. Review. Soriano JB*, Sin DD, Zhang X, Camp PG, Anderson JA, Anthonisen NR, Buist AS, Burge PS, Calverley PM, Connett JE, Petersson S, Postma DS, Szafranski W, Vestbo J. A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo. Chest 2007 Mar;131(3):682-9. Sin DD*, Wong E, Mayers I, Lien DC, Feeny D, Cheung H, Gan WQ, and Man SFP. Effects of nocturnal non-invasive mechanical ventilation on heart rate variability of patients with advanced chronic obstructive pulmonary disease. Chest 2007;131:156-63. Ben Zaken-Cohen S, Paré PD, Man SFP, Sin DD*. The growing burden of COPD and lung cancer in women: examining sex differences in cigarette smoke metabolism. American Journal of Respiratory and Critical Care Medicin 2007;176:113-20. Hogg JC, Chu FS, Tan WC, Sin DD, Patel SA, Paré PD, Martinez FJ, Rogers RM, Make BJ, Criner GJ, Cherniack RM, Sharafkhaneh A, Luketich JD, Coxson HO, Elliott WM, Sciurba FC. Survival Following Lung Volume Reduction in COPD: Insights From Small Airway Pathology. Am J Respir Crit Care Med. 2007 Jun 7.176:454-9. Kolodziej MA, Jensen L, Rowe B, Sin DD. Systematic review of non-invasive positive pressure ventilation in severe COPD. European Respiratory Journal 2007;30:293-306. Tkác J, Man SFP, Sin DD*. Systemic consequences of COPD. Therapeutic Advances in Respiratory Disease 2007;1:47-59. Sin DD*, Greaves L, Kennedy S. The tip of the "ICEBERGS": a national conference to combat the growing global epidemic of COPD in Women. Proceedings of the American Thoracic Society 2007;4:669-70. Sin DD*, Ben Zaken Cohen S, Day A, Coxson H, Paré P. Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and women. Proceedings of the American Thoracic Society 2007;4:671-4. Yerman T, Gan WQ, Sin DD*. The influence of gender on the effects of aspirin in preventing myocardial infarction. BMC Medicine 2007;5:29. Sin DD*, Leung R, Gan WQ, and S.F. Man. Circulating surfactant protein D as a potential lung- specific biomarker of health outcomes in COPD: a pilot study. BMC Pulmonary 2007;7:13. O'Donnell DE, Aaron SD, Bourbeau J, Hernandez P, Marciniuk D, Balter M, Ford G, Gervais A, Goldstein R, Hodder R, Kaplan A, Keenan S, Lacasse Y, Maltais F, Road J, Rocker G, Sin DD, Sinuff T, Voduc N. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease-2007 update. Canadian Respiratory Journal 2007;14 (suppl B):5B-32B.

Tan-Hogg, Dr. Wan C Zhang W, Zhang X, Qiu D, Sandford A, Tan WC. IL-4 receptor genetic polymorphisms and asthma in Asian populations. Respir Med. 2007;101(1):186-90. [epub 2006 Jun 6].

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Ng TP, Niti M, Tan WC, Cao Z, Ong KC, Eng P. Depressive symptoms and chronic obstructive pulmonary disease: effect on mortality, hospital readmission, symptom burden, functional status, and quality of life. Arch Intern Med. 2007 Jan 8;167(1):60-7. Ong BH, Gao Q, Phoon MC, Chow VT, Tan WC, Van Bever HP. Identification of human metapneumovirus and Chlamydophila pneumoniae; in children with asthma and wheeze in Singapore. Singapore Med J. 2007 Apr; 48(4):291-3. James C. Hogg, Fanny S. F. Chu, Wan C. Tan, Don D. Sin, Sanjay A. Patel, Peter D. Pare1, Fernando J. Martinez, Robert M. Rogers, Barry J. Make, Gerard J. Criner, Reuben M. Cherniack, Amir Sharafkhaneh, James D. Luketich, Harvey O. Coxson1, W. Mark Elliott1, and Frank C. Sciurba. Survival after Lung Volume Reduction in Chronic Obstructive Pulmonary Disease. Insights from Small Airway Pathology. Am J Respir Crit Care Med 2007; 176: 454-459. Wan C. Tan. Insights into Early Treatment of Mild Asthma. Do Inhaled Corticosteroids Make a Difference? Pediatr Drugs 2007; 9 (4): 219-226. Wan C Tan, Don Sin, Doug Balson, M Fitzgerald, W Vollmer, S Buist. The Burden of Obstructive Lung Disease [BOLD] study in Vancouver, Canada- Sampling and Recruitment. Canadian Respiratory Journal 2007; 14Suppl A:7A-9A. A Sonia Buist, Mary Ann McBurnie, William M Vollmer, Suzanne Gillespie, Peter Burney, David M Mannino, on behalf of the BOLD Collaborative Research Group* International variation in the prevalence of COPD(The BOLD Study): a population-based prevalence study. Lancet 2007; 370: 741-50. [* Site Investigators listed under this collective group]. Sin, D.D. and W.C. Tan "Breaking Down the "Great Wall" of COPD Care in China" . Am J Respir Crit Care Med 2007; 176(8): 732-3.

Tebbutt, Dr. Scott J Song YC, Kawas E, Good BM, Wilkinson MD, Tebbutt SJ DataBiNS: a BioMoby-based data-mining workflow for biological pathways and non-synonymous SNPs. Bioinformatics 23:780-782 (2007). Tebbutt SJ, James A, Paré, PD. Single-nucleotide polymorphisms and lung disease - clinical implications. Chest 131:1216-1223 (2007). Invited article that was peer-reviewed.

Ward, Dr. Helen Lee KK, Hegele RG, Manfreda J, Wooldrage K, Becker AB, Ferguson AC, Dimich-Ward H, Watson WT, Chan-Yeung M. Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: The Canadian asthma primary prevention study. Pediatr Pulmonol. 2007 Mar;42(3):290-7. Al-Hazmi M, Wooldrage K, Anthonisen NR, Becklake MR, Bowie D, Chan-Yeung M, Dimich-Ward H, Ernst P, Manfreda J, Sears MR, Siersted HC, Sweet L, Van Til L. Airflow obstruction in young adults in Canada.Can Respir J 2007; 14:221-7. Dimich-Ward H, Taliadouros V, Teschke K, Chow Y, Abboud R, Chan-Yeung M. Quality of life and employment status of workers with Western Red Cedar Asthma. J Occup Environ Med 2007; 49:1040-1045. Dimich-Ward H, Lorenzi M, Teschke K, Spinelli J, Ratner PA, Le N, Chow Y, Shu D, Gallagher R. Mortality and Cancer Incidence in a cohort of Registered Nurses from British Columbia, Canada. Am J Industr Med 2007; 50:892-900. Do R, Bartlett KH, Chu W, Dimich-Ward H, Kennedy SM. Within- and between-person variability of exhaled breath condensate pH and NH(4)(+) in never and current smokers. Respir Med 2007. Chan-Yeung M, Dimich-Ward H, Becker A. Atopy in early life and effect of a primary prevention program for asthma in a high-risk cohort. J Allergy Clin Immunol 2007; 120:1221-3. Kennedy SM, Chambers R, Du W, Dimich-Ward H. Environmental and occupational exposures: Do they affect chronic obstructive pulmonary disease differently in women and men? Proc Am Thorac Soc 2007; 4:692-4.

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Wilcox, Dr. Pearce G Al Lawati NM, Wilcox P. Paradoxical embolization in an adult cystic fibrosis patient. Can Respir J. 14:293-294, 2007.

Yeung, Dr. Moira M Beyers N, Chan-Yeung M, Pierard C. Access to knowledge for all: the IJTLD in the top 100. Int J Tuberc Lung Dis 2007; 11:1. Ho JC, Chan-Yeung M, Ho SP, Mak JCW, Ip SM, Ooi GC, Wong MP, Tsang KW Lam WK. Disturbance of systemic antioxidant profile in nonsmall cell lung cancer. Eur Respir J 2007;29:273-8. Lee KK, Hegele RG, Manfreda J, Wooldrage K, Becker AB, Ferguson AC, Dimich-Ward H, Watson WTA, Chan-Yeung M. The Canadian asthma primary prevention study- Exposure to respiratory viruses and onset of asthma and atopy in high risk children: outcome at 2 –years of age. Pediatric Pulmonol 2007; 42:290-7. Chan-Yeung M, Becklake M. Occupational Lung Disease - unrecognised, underestimated and poorly managed- even today. Int J Tuberc Lung dis 2007: 11:119. Beyers N, Pierard C, Enarson DA, Chan-Yeung M. What new knowledge did we gain through the Internationsl Journal of Tuerbculosis and Lung Disease in 2006? In J Tuberc Lung Dis 2007;11:237- 43. Chan-Yeung M, Ho ASS, Cheung AHK, Liu R, Yee WKS, Sin KM, Wong ML, Lam CW, Chan KS, Lam WK, on behalf of the Hong Kong Thoracic Society COPD study group. Determinants of chronic obstructive pulmonary disease (COPD) in Chinese patients in Hong Kong. Int J Tuberc Lung Dis 2007; 11:502-7. Chan-Yeung, M., Mak JCW, Ho SP, Cheung AHK, Wong PC, Chan KK, Ip MS. Glutathione S-transferase (GST) polymorphisms and GST activity in Hong Kong Chinese COPD patients. Int J Tuberc Lung Dis; 2007:11:508-14. Beyers N, Enarson DA, Pierard C, Chan-Yeung M. Response to a case of plagiarism in the International Journal of Tuberculosis and Lung Disease. Int J Tuberc Lung Dis. 2007 May;11(5):473. Begin P, Tremblay K, Daley D, Lemire M, Claveau S, Salesse C, Kacel S, Montpetit A, Becker A, Chan-Yeung M, Kozyrskyj A, Hudson TJ, Laprise C. Association of urokinase-type plasminogen activator with asthma and atopi. Am J Respir Crit Care Med 2007;175:1109-16. Al-Hazmi M, Wooldrage K, Anthonisen NR, Becklake MR, Bowie D, Chan-Yeung M, Dimich-Ward H, Ernst P, Manfreda J, Sears MR, Siersted HC, Sweet L, Van Til L.. Airflow obstruction in young adults. Can J Respir 2007; 14:221-7. Mak, J.C.W., Ko Fanny, So LKY, Chu CM, Leung HCM, Chan HW , Cheung AHK, Ip MSM, Chan-Yeung M. Polymorphisms in the IL-4, IL-4 receptor ? chain, TNF-?, and lymphotoxin-? genes and risk of asthma in Hong Kong Chinese adults. Int Arch Allergy Immunol. 2007;144:114-122. Mak, J.C.W, Ho SP, Yu WC, Choo KL, Chu CM, Yew WW, Lam WK, Chan-Yeung M. Polymorphisms in MnSOD and catalase genes - functional activity study in smokers with or without COPD. Eur Respir J; 2007 June 13 e-pub. Mak JCW, Ho SP, Leung CM, Cheung AKH, Law B, So L , Chan JWM, Ip MS, Chan-Yeung M. Polymorphisms of Glutathione S-transferase genes, GSTT1, GSTM1 and GSTP1, and asthma risk in adults. Clin Exp Allergy 2007; 37:1150-7. Ho PL, Becker M, Chan-Yeung M. Emerging occupational lung infections. Int J Tuberc Lung Dis 2007;11(7):710-21. Ip MS, Lam WK, Lai AY, Ko FW, Lau AC, Ling So, Chan JW, Chan-Yeung M. Reference values of diffusing capacity of nonsmoking Chinese in Hong Kong. Respirology 2007; 12:599-606 Chan-Yeung M, Dai DLK, Cheng AHK, Chan FHW, Kam KM, Tam CM, Leung CC. Tuberculin skin test reaction and body mass index in old age home residents in Hong Kong. J Am Geriatr Society 2007; 55:1592-1597. Chan-Yeung M, Dimich-Ward H, Becker A. Atopy in early life and impact of a primary prevention program for asthma in a high risk cohort. J Allergy Clin Immunol 2007; 120:1221-3.

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Dimich-Ward H, Taliadouros V, Teschke K, Chow Y, Abboud R, Chan-Yeung M. Quality of life and employment status of workers with Western red cedar asthma. J Occup Environ Med 2007; 49:1040-5. Malo JL, Chan-Yeung M. Asthma in the workplace: A Canadian contribution and perspective. Can Respir J 2007;14:407-13. Lau ACW, Ip MS, Lai CKW, Choo KL, Tang KS, Yam LYC , Chan-Yeung M on behalf of the Hong Kong Thoracic Society and American College of Chest Physicians (Hong Kong and Macau Chapter) Variability of the Prevalence of Undiagnosed Airflow Obstruction in Smokers Using Different Diagnostic Criteria. Chest 2007;Nov 7 e- pub. Mak JCW, Leung HCM, Sham ASKa, Mok TYW,Poon YN, Ling SO, Wong K.C, Chan-Yeung M. Genetic polymorphisms and plasma levels of transforming growth factor-?1 in Chinese patients with tuberculosis in Hong Kong. Cytokine 2007; 40:177-82.

RHEUMATOLOGY

Chalmers, Dr. Andrew Almoallim H, Chalmers A, Page G, The High Clinic: a pilot project of a new model for an outpatient, community based teaching clinic in Rheumatology: Medical Teacher. 28(8):713-6, 2006 Dec. Kopec J, Richardson C, Llewellyn-Thomas H, Klinkhoff A, Carswell A, Chalmers A. Osteoarthritis patients Preferences for trade off between Pain Relief and Treatment side effects were Quantified Using a Probabilistic Threshold Technique :Journal of Clinical Epidemiology. Kopec JA. Richardson CG. Llewellyn-Thomas H. Klinkhoff A. Carswell A. Chalmers A. Probabilistic threshold technique showed that patients' preferences for specific trade-offs between pain relief and each side effect of treatment in osteoarthritis varied. Journal of Clinical Epidemiology. 60(9):929-38, 2007 Sep. Richardson CG. Chalmers A. Llewellyn-Thomas HA. Klinkhoff A. Carswell A. Kopec JA. Pain relief in osteoarthritis: patients' willingness to risk medication-induced gastrointestinal, cardiovascular, and cerebrovascular complications. Journal of Rheumatology. 34(7):1569-75, 2007 Jul. Woolfenden AR. Wade NK. Tang P. Chalmers A. Reid G. Teal PA. Uveitis associated with Primary Angiitis of the Central Nervous System. Canadian Journal of Neurological Sciences. 34(1):81-3, 2007 Feb.

Choi, Dr. Hyon K Choi HK, Ford ES, Li C, Curhan G. Prevalence of the Metabolic Syndrome in Patients with Gout - The Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2007;57(1):109-115. Choi HK, Ford ES. Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med. 2007 May;120(5):442-7. Choi HK, Curhan G. Coffee, tea, and caffeine consumption and serum uric acid level: The third national health and nutrition examination survey. Arthritis Rheum. 2007 May 25;57(5):816-821. Forman J., Choi, H., Curhan GC. Plasma uric acid level and risk of incident hypertension among men J Am Soc Nephrol 18: 287-292, 2007. Felson D, Xie H, LaValley M, Anderson J, Koch G, Wolfe F, Michaud K, Furst D, Boers M, Bathon J, Tugwell P, Pincus T, Dougados M, van der Heijde D, Simon L, Smolen J, Aletaha D, Siegel J, Choi HK, Paulus H, Bombardier C, White B, Landewe R. A Proposed Revision to the ACR20: The Hybrid Measure of ACR Response. Arthritis Rheum. 2007 Mar 15;57(2):193-202. Ford ES, Li C, Cook S, Choi HK. Serum Concentrations of Uric Acid and the Metabolic Syndrome Among US Children and Adolescents. Circulation. 2007 May 15;115(19):2526-32. Choi HK, Willett W, Curhan G. Coffee Consumption and Risk of Incident Gout in Men - A Prospective Study. Arthritis Rheum. 2007 May 25;56(6):2049-2055. Smitten AL, Choi HK, Hochberg MC, Suissa S, Simon TA, Testa M, K. Chan A. The risk of herpes zoster in rheumatoid arthritis patients in the United States and the United Kingdom. Arthritis Rheum 2007; 57(8):1431-1438.

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Choi HK, Curhan G. The Independent Impact of Gout on Mortality and Risk for Coronary Heart Disease. Circulation 2007;116(8):894-900. Epub 2007 Aug 13. Setty A, Curhan G, Choi HK Obesity, Waist Circumference, Weight Change and the Risk of Psoriasis in Women - Nurses' Health Study II. Arch Intern Med 2007;167(15):1670-5. Setty A, Curhan G, Choi HK Smoking and the risk of psoriasis in women - Nurses' Health Study II. Am J Med 2007; 120(11):953-9. Gao X, Qi L, Qiao N, Choi HK, Curhan G, Tucker K L, and Ascherio A. Intake of added sugar and sugar-sweetened drink was associated with serum uric acid concentration. Hypertension 2007;50(2):306-12. Epub 2007 Jun 25. Taylor WJ, Schumacher HR, Baraf HSB, Chapman P, Stamp L, Doherty M, McQueen F, Dalbeth N, Schlesinger N, Furst DE, Vazquez-Mellado J, Becker MA, Kavanaugh A, Louthrenoo W, Bardin T, Khanna D, Simon LS, Yamanaka H, Choi HK, Zeng X, Strand V, Grainger R, Clegg D, Singh JA, Diaz-Torne C, Boers M, Gow P, Barskova VG. A Modified Delphi Exercise To Determine The Extent Of Consensus With OMERACT Outcome Domains For Studies Of Acute And Chronic Gout. Ann Rheum Dis 2007 Nov 29; [Epub ahead of print]. Gao X, Qi L, Qiao N, Choi HK, Curhan G, Tucker K L, and Ascherio A. Intake of added sugar and sugar-sweetened drink was associated with serum uric acid concentration. Hypertension 2007; 50(2):306-12. Epub 2007 Jun 25. Choi JJW, Ford ES, Gao X, Choi HK. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level - The Third National Health and Nutrition Examination Survey. Arthritis Rheum 2008; 59(1):109-16. Choi HK, Curhan G. Soft drinks, fructose consumption, and the risk of gout in men - A prospective cohort study. BMJ 2008; 336(7639):309-12. Epub 2008 Jan 31.

Cibere, Dr. Jolanda Gossec L, Hawker G, Davis AM, Maillefert JF, Lohmander LS, Altman R, Cibere J, Conaghan PG, Hochberg MC, Jordan JM, Katz JN, March L, Mahomed N, Pavelka K, Roos EM, Suarez-Almazor ME, Zanoli G, Dougados M. OMERACT/OARSI initiative to define states of severity and indication for joint replacement in hip and knee osteoarthritis. J Rheumatol 2007;36:1432-5. Marra C, Cibere J, Tsuyuki R, Soon J, Esdaile J, Gastonguay L, Oteng B, Embley P, Colley L, Enenajor G, Kok R. Improving osteoarthritis detection in the community: Pharmacist Identification of New, Diagnostically Confirmed Osteoarthritis. Arthritis Rheum 2007;57(7):1238-1244. McWalter EJ, Cibere J, Nicolaou S, MacIntyre NJ, Nicolaou S, Schulzer M, Wilson DR. Relationship between varus-valgus alignment and patellar kinematics in individuals with knee osteoarthritis. J Bone Joint Surg Am 2007;89:2723-31. Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Differential association of biomarkers with pre-radiographic and radiographic knee osteoarthritis in a population based study. Arthritis Rheum 2007 (under revision)

Esdaile, Dr. John M Li X, Guh D, Lacaille D, Esdaile J, Anis AH. The impact of cost sharing of prescription drug expenditures on health care utilization by the elderly: own-and cross-price elasticities. Health Policy 2007;82:340-7. Panopalis P, Petri M, Manzi S, Isenberg DA, Gordon, Senecal JL, Penrod J, Joseph L, St. Pierre Y, Pineau C, Fortin PR, Sutcliffe N, Goulet JR, Choquette D, Grodzicky T, Esdaile JM, Clarke AE for the Tri-Nation Study Group. The systemic lupus erythematosus Tri-Nation study: Cumulative indirect costs. Arthritis Rheum 2007;15:64-70. Marra CA, Marion SA, Guh DP, Najafzadeh M, Wolfe F, Esdaile JM, Clarke AE, Gignac MA, Anis AH. Not all “quality-adjusted life years” are equal. J Clinical Epidemiol 2007;60:616-24.

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Marra CA, Cibere J, Tsuyuki RT, Soon JA, Esdaile JM, Gastonguay L, Oteng B, Embley P, Colley L, Enenajor G, Kok R. Improving osteoarthritis detection in the community: pharmacist identification of new, diagnostically confirmed osteoarthritis. Arthritis Rheum 2007;57:1238-44. Al-Herz A, Snip JP, Clarke B, Esdaile JM. Exercise therapy for patients with diffuse idiopathic skeletal hyperostosis. Clin Rheumatol 2007 Sep 21; [Epub ahead of print].

Gillies, Dr. Jean H Ratzlaff CR, Gillies JH, Koehoorn MW. Work-related repetitive strain injury and leisure-time physical activity. Arthritis Rheum. 2007 Apr 15;57(3):495-500. Maxwell NJ, Ryan MB, Taunton JE, Gillies JH, Wong AD. Sonographically guided intratendinous injection of hyperosmolar dextrose to treat chronic tendinosis of the Achilles tendon: a pilot study. AJR Am J Roentgenol. 2007 Oct;189(4):W215-20.

Kopec, Dr. Jacek Kopec JA, Yothers G, Ganz PA, Land RS, Cecchini SL, Wieand HS, Lembersky B, Wolmark N. Quality of Life in Operable Colon Cancer Patients Receiving Oral versus Intravenous Chemotherapy: Results from the National Surgical Adjuvant Breast and Bowel Project Trial C-06. J Clin Oncol 2007 Feb 1;25(4):424-30. Dhalla S, Kopec JA. The CAGE Questionnaire: A Review of Reliability and Validity Studies. Clin Invest Med 2007;30(1):33-41. Kopec JA, Richardson C, Llewellyn-Thomas H, Klinkhoff A, Carswell A, Chalmers A. Probabilistic threshold technique showed that patients' preferences for specific tradeoffs between pain relief and each side effect of treatment in osteoarthritis varied. J Clin Epidemiol 2007;60(9):929-38. Epub 2007 May 8. Land SR, Kopec JA, Cecchini RS, Ganz PA, Wieand HS, Colangelo LH, Murphy K, Kuebler JP, Seay TE, Needles BM, Bearden JD, Colman LK, Lanier KS, Pajon ER, Jr, Cella D, Smith RE, O'Connell MJ, Costantino JP, Wolmark N. Neurotoxicity with Oxaliplatin Combined with Weekly Bolus 5-Fluorouracil and Leucovorin as Surgical Adjuvant Chemotherapy for Stage II and III Colon Cancer: Results from NSABP Protocol C-07. J Clin Oncol 2007;25(16):2205-11. Epub 2007 Apr 30. Richardson C, Chalmers A, Kopec JA, Llewellyn-Thomas H, Klinkhoff A, Carswell A. Pain Relief in Osteoarthritis: Patients' Willingness to risk medication-induced gastrointestinal, cardiovascular, and cerebrovascular complications. J Rheumatol 2007;34(7):1569-75. Epub 2007 Jun 1. Pouchot J, Kherani RB, Brant R, Lacaille D, Lehman AJ, Ensworth S, Kopec JA, Esdaile JM, Liang, MH. Fatigue in rheumatoid arthritis: determination of the minimal clinically important difference for seven fatigue measures. J Clin Epidemiol (accepted, August 2007) Noonan VK, Kopec JA, Zangh H, Dvorak MF. The impact of associated conditions resulting from spinal cord injury on the health status and quality of life in individuals with traumatic central cord syndrome. Arch Phys Med Rehab (accepted, October 2007) Kopec JA, Sayre EC. ROC Area Discrimination (ROCAD) Curve: a new method of evaluating the discriminating ability of ordinal scales. J Clin Epidemiol (accepted, November 2007) Goligher EC, Pouchot J, Brant R, Kherani RB, Avina-Zubieta A, Lacaille D, Lehman AJ, Ensworth S, Kopec JA, Esdaile JM, Liang MH. The minimal clinically important difference for seven measures of fatigue in patients with systemic lupus erythematosus. J Rheum (accepted, November, 2007) Kopec JA, Rahman MM, Aghajanian J, Sayre EC, Cibere J, Anis AH, Badley EM. Trends in physician-diagnosed osteoarthritis incidence in an administrative database in British Columbia, Canada, 1996/7 - 2003/4. Arthritis Care Res (accepted, December 2007)

Kur, Dr. Jason Kur J and Esdaile JM. Posterior Reversible Encephalopathy - An Under Recognized Manifestation of Systemic Lupus Erythematosus. J Rheum 2006; 33:2178-83.

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Lacaille, Dr. Diane V Adam P, White M, Lacaille D. Arthritis and self-employment: Strategies that people with arthritis have found to be helpful. J Vocational Rehabilitation 2007;26(3):141-152. Li X, Guh D, Lacaille D, Esdaile J, Anis AH. The impact of cost sharing of prescription drug expenditures on health care utilization by the elderly: Own- and cross-price elasticities. Health Policy 2007;82(3):340-7. Abrahamowicz M, Xiao Y, Ionescu-Ittu R, Lacaille D. Simulations showed that validation of database-derived diagnostic criteria based on a small sub-sample reduced bias. J Clin Epidemiol 2007;60:600-9. Escorpizo R, Bombardier C, Boonen A, Hazes JMW, Lacaille D, Strand V, Beaton D. Worker Productivity Outcome Measures in Arthritis. J Rheumatology 2007;34(6):1372-80. (authors other than 1st and last are listed by alphabetical order. All had equal contribution). *Lacaille D, White MA, Backman CL, Gignac MA. Problems faced at work due to inflammatory arthritis: New insights gained from understanding patients’ perspectives. Arthritis Rheum 2007;57(7):1269-79.

LePage, Dr. Judy A Iverson G.L., Le Page J., Koehler B.E., Shojania K., Badii, M. (2007). TOMM scores are not affected by chronic pain or depression in patients with fibromyalgia. The Clinical Neuropsychologist, 21(3), 532-46.

Shojania, Dr. Kamran Iverson GL, Le Page J, Koehler BK, Shojania K, Badii M. Test of memory malingering (TOMM) scores are not affected by chronic pain or depression in patients with fibromyalgia. Clinical Neuropsychologist 2007;21:532-46. de Gannes GC, Ghoreishi M, Pope J, Russell A, Bell D, Adams S, Shojania K, Martinka M, Dutz JP. Psoriasis and pustular dermatitis triggered by TNF alpha inhibitors in patients with rheumatologic conditions. Arch Dermatol 2007;143:223-31. Kherani RB, Shojania K. Septic arthritis in patients with pre-existing inflammatory arthritis. CMAJ 176:1605-8. Maksymowych, WP, Gladman D, Rahman P, Boonen A, Bykerk V, Choquette D, Dimond S, Fortin P, Karsh J, Klinkhoff AV, Mosher D, Mulholland K, Olszynski WP, Russell AS, Savage L, Shanner L, Shojania K, Starr M, Thomson G, Zummer M, Inman R. The Canadian Rheumatology Association/Spondylitis Research Consortium of Canada treatment recommendations for the management of Spondyloarthritis: A national multidisciplinary stakeholder project. J Rheumatol 2007;34:2273-84. Reynolds J, Shojania K, Marra CA. Abatacept: A novel treatment for moderate to severe rheumatoid arthritis. Pharmacotherapy 2007;27(12):1693-701.

Tsang, Dr. Ian K Tsang I.K. Establishing the Efficacy of Traditional Chinese Medicine, Nature Clinical Practice Rheumatology (2007) 3, 60-61.

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