Datasheet Inhibitors / Agonists / Screening Libraries a DRUG SCREENING EXPERT

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Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT Product Name : Thunberginol C Catalog Number : TMA0955 CAS Number : 147517-06-4 Molecular Formula : C15H12O5 Molecular Weight : 272.30 Description: Thunberginol C exhibits antimicrobial activity against oral bacteria. It shows antiallergic activity in the in vitro bioassay using the Schults-Dale reaction in sensitized guinea pig bronchial muscle. Storage: 2 years -80°C in solvent; 3 years -20°C powder; Receptor (IC50) Antifection In vitro Activity METHODS AND RESULTS: New antiallergic and antimicrobial dihydroisocoumarins, thunberginols C, D, and E, were isolated from Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, together with new dihydroisocoumarin glycosides, thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. CONCLUSIONS: Thunberginol C, D, E, G, and (-)-hydrangenol 4'-O-glucoside showed antiallergic activity in the in vitro bioassay using the Schults-Dale reaction in sensitized guinea pig bronchial muscle, and they also exhibited antimicrobial activity against oral bacteria. Reference 1. Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (- )-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium. Chem Pharm Bull (Tokyo). 1992 Dec;40(12):3352-4. 2. Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)- hydrang. Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1440-7. FOR RESEARCH PURPOSES ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE. Information for product storage and handling is indicated on the product datasheet. Targetmol products are stable for long term under the recommended storage conditions. Our products may be shipped under different conditions as many of them are stable in the short-term at higher or even room temperatures. We ensure that the product is shipped under conditions that will maintain the quality of the reagents. Upon receipt of the product, please follow the storage recommendations on the product data sheet. [email protected] | Tel: +1-781-999-4286 | www.targetmol.com.

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Ep 1384475 A1
Europäisches Patentamt *EP001384475A1* (19) European Patent Office Office européen des brevets (11) EP 1 384 475 A1 (12) EUROPEAN PATENT APPLICATION published in accordance with Art. 158(3) EPC (43) Date of publication: (51) Int Cl.7: A61K 31/352, C07D 311/76, 28.01.2004 Bulletin 2004/05 A61P 1/16, A23L 1/30, A23K 1/16 (21) Application number: 02713236.4 (86) International application number: (22) Date of filing: 28.03.2002 PCT/JP2002/003098 (87) International publication number: WO 2002/080904 (17.10.2002 Gazette 2002/42) (84) Designated Contracting States: • KAYAHASHI, Shun, AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU Tsukuba Research Laboratories MC NL PT SE TR Tsukuba-shi, Ibaraki 305-0841 (JP) Designated Extension States: • HASHIZUME, Erika, AL LT LV MK RO SI Tsukuba Research Laboratories Tsukuba-shi, Ibaraki 305-0841 (JP) (30) Priority: 05.04.2001 JP 2001106600 • NAKAGIRI, Ryusuke, Tsukuba Research Laboratories (71) Applicant: KYOWA HAKKO KOGYO CO., LTD. Tsukuba-shi, Ibaraki 305-0841 (JP) Chiyoda-ku, Tokyo 100-8185 (JP) (74) Representative: Casalonga, Axel et al (72) Inventors: BUREAU D.A. CASALONGA - JOSSE • SAKAI, Yasushi, Paul-Heyse-Strasse 33 Foods & Liquors Research Laborat. 80336 München (DE) Inashiki-gun, Ibaraki 300-0398 (JP) (54) LIVER FUNCION PROTECTING OR AMELIORATING AGENT (57) A liver function protecting or improving agent which comprises a compound represented by the formula (I) {in the formula (I), R1,R2,R3,R4,R5,R6,R7,R8and R9 may be the same or different, and represent hydrogen, halogen, hydroxy, alkoxy or alkyl; and RA represents the formula (II) EP 1 384 475 A1 Printed by Jouve, 75001 PARIS (FR) (Cont.
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1 AMINO ACIDS Commonly, 21 L-Amino Acids Encoded by DNA Represent the Building Blocks of Animal, Plant, and Microbial Proteins
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Chem. Pharm. Bull. 61(6): 655-661 (2013)
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