Uniformed Services University of the Health Sciences
Board of Regents Quarterly Meeting
October 2014
BOARD OF REGENTS UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 189th MEETING
October 14, 2014 Hershey Lodge Hershey, Pennsylvania
CONTENTS
Matters of Information
Federal Register: Notice of Partially Closed Meeting ...... 1 Board of Regents...... 2 Charter...... 3 Bylaws...... 4 Meeting Calendars ...... 5
Winter Meeting: February 2-3, 2015 Spring Meeting: May 14-16, 2015 Summer Meeting: August 3-4, 2015 Fall Meeting: November 2-3, 2015
Chair’s Opening Comments ...... 6
Matters of General Consent
Board Meeting Minutes, August 5, 2014 ...... 7 Declaration of Board Actions ...... 8
Board Actions
Degree Granting, School of Medicine Graduate Programs ...... 9-18 Faculty Appointments and Promotions, School of Medicine ...... 19 Faculty Appointments and Promotions, Postgraduate Dental College ...... 20 Awards and Honors...... 21-22
President’s Report ...... 23
Reports to the Board of Regents
Armed Forces Radiobiology Research Institute ...... 24 F. Edward Hébert School of Medicine ...... 25-26 Daniel K. Inouye Graduate School of Nursing ...... 27 Postgraduate Dental College ...... 28
TAB 1
Federal Register: Notice of Partially Closed Meeting 56348 Federal Register / Vol. 79, No. 182 / Friday, September 19, 2014 / Notices
that the Settlement Agreement and the the provisions of the Federal Advisory personnel rules and practices of the Order are in the public interest, it is Committee Act of 1972 (5 U.S.C., agency, will involve allegations or ORDERED that the Settlement Appendix, as amended), the findings of a person having committed Agreement be, and is, hereby, accepted; Government in the Sunshine Act of a crime or censuring an individual, and and it is 1976 (5 U.S.C. 552b, as amended), and may disclose investigatory records FURTHER ORDERED, that Meijer 41 CFR part 102–3.150. compiled for law enforcement purposes. shall comply with the terms of the Purpose of the Meeting: The purpose Written Statements: Pursuant to 41 Settlement Agreement and shall pay a of the meeting is to review the CFR part 102–3.140, and section 10(a)(3) civil penalty of two million dollars operations of USU, particularly the of the Federal Advisory Committee Act ($2,000,000.00 U.S. dollars), within academic affairs, and provide advice to of 1972, the public or interested twenty (20) calendar days after receiving the USU President and the Assistant organizations may submit written service of the Commission’s final Order Secretary of Defense for Health Affairs comments to the Board about its accepting the Settlement Agreement. (who represents the Secretary of approved agenda pertaining to this Upon failure of Meijer to make the Defense). These actions are necessary meeting, or at any time on the Board’s foregoing payment when due, interest for the University to pursue its mission, mission. Interested persons may submit on the unpaid amount shall accrue and which is to provide outstanding a written statement for consideration by be paid by Meijer at the federal legal healthcare practitioners and scientists to the Board. Individuals submitting a rate of interest set forth at 28 U.S.C. the uniformed services, and to obtain written statement must submit their 1961(a) and (b). If Meijer fails to make institutional accreditation. statement to the Designated Federal such a payment or to comply in full Agenda: The actions that will take Officer at the address listed in FOR with any other provision as set forth in place include the approval of minutes FURTHER INFORMATION CONTACT. If such the Settlement Agreement, such conduct from the Board Meeting held on August statement is not received at least 5 will be considered a violation of the 5, 2014; recommendations regarding the calendar days prior to the meeting, it Settlement Agreement and Order. approval of faculty appointments and may not be provided to or considered by Provisionally accepted and promotions; recommendations regarding the Board until a later date. The provisional Order issued on the16th day the awarding of post-baccalaureate Designated Federal Officer will compile of September, 2014. degrees; and the review of awards and all timely submissions with the Board’s By Order of the Commission. honors. The USU President will provide Chairman and ensure such submissions lllllllllllllllllllll a report on recent actions affecting are provided to Board Members before Todd A. Stevenson, academic and operations of the the meeting. Secretary, U.S. Consumer Product Safety University. The Armed Forces Commission. Radiobiology Research Institute will Dated: September 16, 2014. [FR Doc. 2014–22344 Filed 9–18–14; 8:45 am] provide an operational update; the F. Aaron Siegel, BILLING CODE 6355–01–P Edward He´bert School of Medicine will Alternate OSD Federal Register Liaison provide academic updates to include Officer, Department of Defense. initiatives and collaborations; the Daniel [FR Doc. 2014–22399 Filed 9–18–14; 8:45 am] DEPARTMENT OF DEFENSE K. Inouye Graduate School of Nursing BILLING CODE 5001–06–P will present an update on academic Office of the Secretary activities and collaborations; and the Postgraduate Dental College will DEPARTMENT OF DEFENSE Board of Regents, Uniformed Services provide an update on academic University of the Health Sciences; activities. A closed session will be held Office of the Secretary Notice of Federal Advisory Committee to discuss personnel actions and active Meeting investigations. U.S. Strategic Command Strategic Meeting Accessibility: Pursuant to Advisory Group; Notice of Advisory AGENCY: Uniformed Services University Federal statute and regulations (5 U.S.C. Committee Closed Meeting of the Health Sciences (USU), 552b and 41 CFR parts 102–3.140 AGENCY: Department of Defense. Department of Defense. through 102–3.165) and the availability ACTION: ACTION: Quarterly meeting notice. of space, the meeting is open to the Notice of Advisory Committee closed meeting. SUMMARY: The Department of Defense is public from 2:00 p.m. to 3:45 p.m. publishing this notice to announce the Seating is on a first-come basis. SUMMARY: The Department of Defense is following meeting of the Board of Members of the public wishing to attend publishing this notice to announce the Regents, Uniformed Services University the meeting should contact Jennifer following Federal Advisory Committee of the Health Sciences (‘‘the Board’’). Nuetzi James at the address and phone meeting of the U.S. Strategic Command number noted in the FOR FURTHER DATES: Tuesday, October 14, 2014, from Strategic Advisory Group. This meeting 2:00 p.m. to 3:45 p.m. (Open Session) INFORMATION CONTACT section. will be closed to the public. Pursuant to 5 U.S.C. 552b(c)(2, 5–7) and 4:00 p.m. to 5:00 p.m. (Closed the Department of Defense has DATES: Thursday, October 16, 2014, Session). determined that the portion of the from 8:00 a.m. to 5:00 p.m. and Friday, ADDRESSES: Hershey Lodge, 325 meeting from 4:00 p.m. to 5:00 p.m. October 17, 2014, from 8:00 a.m. to University Drive, Hershey, PA 17033. shall be closed to the public. The Under 11:00 a.m. FOR FURTHER INFORMATION CONTACT: Secretary of Defense (Personnel and ADDRESSES: Dougherty Conference Jennifer Nuetzi James, Designated Readiness), in consultation with the Center, Building 432, 906 SAC Federal Officer, 4301 Jones Bridge Road, Office of the DoD General Counsel, has Boulevard, Offutt AFB, Nebraska 68113. D3002, Bethesda, Maryland 20814; determined in writing that a portion of FOR FURTHER INFORMATION CONTACT: Mr. telephone 301–295–3066; email the committee’s meeting will be closed Bruce Sudduth, Designated Federal [email protected]. as the discussion will disclose sensitive Officer, (402) 294–4102, 901 SAC SUPPLEMENTARY INFORMATION: This personnel information, will include Boulevard, Suite 1F7, Offutt AFB, NE meeting notice is being published under matters that relate solely to the internal 68113–6030.
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SEP 1 5 2014
MEMORANDUM FOR DESIGNATED FEDERAL OFFICER, BOARD OF REGENTS, UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES
SUBJECT: Determination to Close a Portion of the Board of Regents, Uniformed Services University of the Health Sciences Meeting on October 14, 2014
I find that the request to close a portion of the fall meeting of the Board of Regents, Uniformed Services University of the Health Sciences ("the Board"), from roughly 4:00 pm until 5:00 pm on October 14, 2014, is consistent with provisions outlined in the Government in the Sunshine Act, 5 U.S.C. § 552b(c)(2, 5-7), and the Federal Advisory Committee Act, 5 U.S.C. Appendix. Therefore, I determine that the prescribed portion of the meeting shall be closed to the public.
The reason for my determination is that this portion of the meeting will disclose sensitive personnel information, includes matters that relate solely to the internal personnel rules and practices of the University, will involve accusing a person of a crime or censuring an individual, and may disclose investigatory records compiled for law enforcement purpose.
Specifically, the portions of the meeting that will be closed are the discussions on personnel actions and active investigations.
As required by 41 C.F.R. § 102-3.155(d), you shall insure that a copy ofthis determination is made available to the public upon request. In light of this determination, you shall also comply with all requirements for reporting closed meetings as specified in Department of Defense Instruction 510 5. 04.
cc: Group Federal Officer Advisory Committee Management Officer
TAB 2
Board of Regents BOARD OF REGENTS UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES October 2014
NAME TITLE TERM EXP
Ronald R. Blanck, D.O. Chair, Board of Regents June 20, 2019 Otis W. Brawley, M.D. Member, Board of Regents March 9, 2015 Sheila P. Burke, M.P.A. Member, Board of Regents July 19, 2017 Haile T. Debas, M.D. Member, Board of Regents June 20, 2019 GEN Ronald H. Griffith, USA (Ret) Member, Board of Regents November 4, 2015 Michael M.E. Johns, M.D. Member, Board of Regents June 20, 2019 Kenneth P. Moritsugu, M.D., M.P.H. Member, Board of Regents June 20, 2019 Charles S. Robb, J.D. Member, Board of Regents November 4, 2015 Gail R. Wilensky, Ph.D. Member, Board of Regents June 20, 2019 Jonathan Woodson, M.D. Assistant Secretary of Defense for Health Ex Officio Affairs* Charles L. Rice, M.D. President, USU** Ex Officio LTG Patricia D. Horoho, AN, USA Surgeon General, United States Army Ex Officio VADM Matthew L. Nathan, MC, USN Surgeon General, United States Navy Ex Officio Lt Gen Thomas W. Travis, USAF, MC Surgeon General, United States Air Force Ex Officio RADM Boris D. Lushniak, USPHS Acting Surgeon General of the United Ex Officio States
Gen Thomas R. Morgan, USMC (Ret) Military Advisor to the Board Advisor Arthur L. Kellermann, M.D., M.P.H. Dean, F. Edward Hébert School of Advisor Medicine Marguerite Littleton-Kearney, Ph.D., Acting Dean, Graduate School of Nursing Advisor R.N. Patrick D. Sculley, D.D.S., M.A. Executive Dean, Postgraduate Dental Advisor College Col L. Andrew Huff, USAF, MC Director, Armed Forces Radiobiology Advisor Research Institute RDML Raquel C. Bono, MC, USN Director, National Capital Region Medical Advisor Directorate Maj Gen Bart O. Iddins, USAF, MC Commander, 59th Medical Wing Advisor BG Robert D. Tenhet, MSC, USA Commanding General, Northern Regional Advisor Medical Command Maj Gen Roosevelt Allen, Jr., USAF, DC Commander, 79th Medical Wing Advisor BG Jeffrey B. Clark, MC, USA Director, Walter Reed National Military Advisor Medical Center COL John H. Garr, MC, USA Commander, Defense Medical Readiness Advisor Training Institute Joshua Girton, J.D. Legal Advisor to the Board of Regents Advisor
Jeffrey L. Longacre, M.D. Executive Secretary Jennifer Nuetzi James Designated Federal Officer
*The Assistant Secretary of Defense for Health Affairs is not a statutory member of the Board of Regents but represents the Secretary of Defense, who is by statute an ex officio member. **The President, USU is a non-voting ex officio member as defined by statute.
TAB 3
Charter Charter Board of Regents, Uniformed Services University of the Health Sciences
1. Committee’s Official Designation: The Committee shall be known as the Board of Regents, Uniformed Services University of the Health Sciences (“the Board”).
2. Authority: The Secretary of Defense, pursuant to the provisions of 10 U.S.C. § 2113a, the Federal Advisory Committee Act (FACA) of 1972 (5 U.S.C., Appendix, as amended), and 41 C.F.R. § 102-3.50(a), established the Board.
3. Objectives and Scope of Activities: The Board shall assist the Secretary of Defense in an advisory capacity in carrying out the Secretary’s responsibility to conduct the business of the Uniformed Services University of the Health Sciences (“the University”), as set out in paragraph four below.
4. Description of Duties: The Board shall provide advice and recommendations on academic and administrative matters critical to the full accreditation and successful operation of the University.
5. Agency or Official to Whom the Committee Reports: The Board shall report to the Secretary of Defense, through the Under Secretary of Defense for Personnel and Readiness (USD(P&R)). The USD(P&R), pursuant to Department of Defense (DoD) policy, may act upon the Board’s advice and recommendations.
6. Support: The DoD, through the Office of the USD(P&R), shall provide support, as deemed necessary, for the performance of the Board’s functions and shall ensure compliance with the requirements of the FACA, the Government in the Sunshine Act of 1976 (5 U.S.C. § 552b, as amended) (“the Sunshine Act”), governing Federal statutes and regulations, and established DoD policies and procedures.
7. Estimated Annual Operating Costs and Staff Years: The estimated annual operating cost, to include travel, meetings, and contract support, is approximately $212,000.00. The estimated annual personnel costs to the DoD are 1.8 full-time equivalents.
8. Designated Federal Officer: The Board’s Designated Federal Officer (DFO), pursuant to DoD policy, shall be a full-time or permanent part-time DoD employee, and shall be appointed in accordance with established DoD policies and procedures.
The Board’s DFO is required to be in attendance at all meetings of the Board and its subcommittees for the entire duration of each and every meeting. However, in the absence of the Board’s DFO, a properly approved Alternate DFO, duly appointed to the Board according to established DoD policies and procedures, shall attend the entire duration of meetings of the Board or its subcommittees.
The DFO, or the Alternate DFO, shall call all of the Board and its subcommittees meetings; prepare and approve all meeting agendas; and adjourn any meeting when the DFO, or the Alternate DFO, determines adjournment to be in the public interest or required by governing regulations or DoD policies and procedures.
1
Charter Board of Regents, Uniformed Services University of the Health Sciences
9. Estimated Number and Frequency of Meetings: The Board shall meet at the call of the Board’s DFO, in consultation with the Board’s Chairperson. The Board shall meet at least once a quarter.
10. Duration: The need for this advisory function is on a continuing basis; however, this charter is subject to renewal every two years.
11. Termination: The Board shall terminate upon repeal of 10 U.S.C. § 2113a.
12. Membership and Designation: Under the provisions of 10 U.S.C. § 2113a(b), the Board shall be composed of 15 members, appointed as specified below:
a. Nine persons outstanding in the field of health care, higher education administration, or public policy, who shall be appointed from civilian life by the Secretary of Defense;
b. The Secretary of Defense, or his designee, who shall be an ex-officio member;
c. The Surgeons General of the Uniformed Services, who shall be ex-officio members; and
d. The President of the University, who shall be a non-voting, ex-officio member.
As directed by 10 U.S.C. § 2113a(c), the term of office for each member of the Board (other than ex-officio members) shall be six years except that:
a. Any member appointed to fill a vacancy occurring before the expiration of the term for which his predecessor was appointed shall be appointed for the remainder of such term; and,
b. Any member whose term of office has expired shall continue to serve until his successor is appointed.
In accordance with 10 U.S.C. § 2113a(d), one of the members of the Board (other than an ex- officio member) shall be designated as Chairman by the Secretary of Defense and shall be the presiding officer of the Board.
Board members that are not ex-officio members shall be appointed by the Secretary of Defense and their appointments will be renewed on an annual basis according to DoD policies and procedures. Members of the Board, who are not full-time or permanent part- time Federal employees, shall be appointed as experts and consultants, under the authority of 5 U.S.C. § 3109, to serve as special government employee (SGE) members.
Pursuant to 10 U.S.C. § 2113a(e), members of the Board (other than ex-officio members), while attending conference or meetings or while otherwise performing their duties as members, shall be entitled to receive compensation at a rate to be fixed by the Secretary of Defense; and shall also be entitled to receive an allowance for necessary travel expenses while so serving away from their place of residence.
2
Charter Board of Regents, Uniformed Services University of the Health Sciences
Each member of the Board is appointed to provide advice to the Government on the basis of his or her best judgment without representing any particular point of view and in a manner that is free from conflict of interest.
13. Subcommittees: DoD, when necessary and consistent with the Board’s mission and DoD policies and procedures, may establish subcommittees, task forces, and working groups to support the Board. Establishment of subcommittees will be based upon a written determination, to include terms of reference, by the Secretary of Defense, the Deputy Secretary of Defense, or the USD(P&R), as the DoD Sponsor. All subcommittees, task forces, or working groups shall operate under the provisions of FACA, the Sunshine Act, governing Federal statutes and regulations, and established DoD policies and procedures.
Such subcommittees shall not work independently of the Board, and shall report all their recommendations and advice solely to the Board for full and open deliberation and discussion. Subcommittees have no authority to make decisions and recommendations, verbally or in writing, on behalf of the Board. No subcommittee or any of its members can update or report, verbally or in writing, on behalf of the Board, directly to DoD or any Federal officer or employee.
The Secretary of Defense shall appoint subcommittee members even if the member in question is already a Board member. Subcommittee members, with the approval of the Secretary of Defense, may serve a term of service on the subcommittee of one-to-four years, as determined by the Secretary; however, no member, unless authorized by the Secretary of Defense, may serve more than two consecutive terms of service.
Subcommittee members, if not full-time or part-time Government employees, shall be appointed as experts and consultants, under the authority of 5 U.S.C. § 3109, to serve as SGE members. The Secretary of Defense or the Deputy Secretary of Defense must renew appointments on an annual basis. With the exception of travel and per diem for official travel related to the Board or its subcommittees, subcommittee members shall serve without compensation.
Each subcommittee member is appointed to provide advice to the Government on the basis of his or her best judgment without representing any particular point of view and in a manner that is free from conflict of interest.
All subcommittees operate under the provisions of the FACA, the Sunshine Act, governing Federal statutes and regulations, and established DoD policies and procedures.
14. Recordkeeping: The records of the Board and its subcommittees shall be handled according to Section 2, General Records Schedule 26, and governing DoD policies and procedures. These records shall be available for public inspection and copying, subject to the Freedom of Information Act of 1966 (5 U.S.C. § 552, as amended).
15. Filing Date: May 2, 2013
3
TAB 4
Bylaws Bylaws of the Board of Regents of the Uniformed Services University of the Health Sciences
Article I
Establishment. The Board of Regents of the Uniformed Services University of the Health Sciences (USU), hereinafter the Board, is established by 10 U.S. Code § 2 l l 3a.
Description. The Board is a Federal Advisory Committee within the Department of Defense and operates in accordance with the Federal Advisory Committee Act (FACA), DoD Instruction 5105.04, "Federal Advisory Committee Management Program," DoD Directives and Instmctions specifically and generally applicable to USU, and its DoD Charter.
Article II
Purpose.
A. The purpose of the Board shall be to provide advice and guidance to the Secretary of Defense; the Under Secretary of Defense for Personnel and Readiness; the Assistant Secretary of Defense for Health Affairs; the Director, TRICARE Management Activity; and the USU President in order to ensure that the operation of USU is effective, in compliance with all applicable accreditation standards, and in the best traditions of academia.
B. The purpose of these bylaws is to set forth the organization of the Board and to outline the procedures it uses to accomplish its responsibilities as an advisory committee.
Article III
Members. Pursuant to 10 U.S. Code§ 2113a, the Board shall consist of:
A. Nine persons, outstanding in the fields of health care, higher education administration, or public policy, who shall be appointed from civilian life by the Secretary of Defense; B. The Secretary of Defense, or the Secretary's designee, who shall be an ex officio member;
C. The Surgeons General of the Uniformed Services who shall be ex officio members; and
D. The USU President, who shall be a nonvoting ex officio member.
Representatives. Individual members of the Board, to include the designee of the Secretary of Defense, may be represented at meetings of the Board and at committee meetings by representatives, provided these representatives are Federal government employees or members of the Armed Services and provided they arc appointed in advance and in writing. Representatives should be appointed with continuity in mind and should have authority to speak for the represented members.
Tem1 of Office. The tenn of office for each member of the Board (other than an ex officio member) shall be six years except that:
A. Any member of the Board appointed to fill a vacancy occurring before the expiration of the term for which a predecessor was appointed, shall be appointed for the remainder of such term.
B. Any member of the Board whose term of office has expired shall continue to serve until a successor is appointed. These appointments will be renewed annually on the anniversary of the original appointment date.
Appointment of Chair. One of the members of the Board (other than an ex officio member) shall be designated by the Secretary of Defense as Chair and shall be the presiding officer of the Board. The term of the Chair shall continue until a successor is appointed.
Selection of Vice-Chair. The Chair of the Board shall select an appointed member of the Board to serve as Vice Chair.
Article IV
Duties and Responsibilities. The Board shall:
A. Advise the Secretary of Defense, through the Assistant Secretary of Defense for Health Affairs and the Under Secretary of Defense for Personnel and Readiness, · regarding the appointment of the USU President and advise the USU President regarding the appointments of deans of USU schools, directors of USU institutes and similar USU administrative positions;
2 B. Be informed by the USU President of the appointments of vice presidents, assistant vice presidents and similar USU staff positions; or by the appropriate dean of the appointments of associate deans, assistant deans, department chairs and similar USU faculty positions;
C. Advise the USU President on the awarding of appropriate academic degrees to successful candidates after first receiving and considering the recommendations of the faculty and deans of USU schools;
D. Advise the USU President on the conferring of honors (to include Professor Emeritus, Senior Lecturer, and Distinguished Professor) and honorary degrees after first receiving and considering the recommendations of the deans of USU schools;
E. Provide its advice on policies and procedures intended to ensure that USU maintains appropriate accreditation requirements;
F. Consider recommendations made by USU Committees on Appointments, Promotion, and Tenure and provide its advice on these recommendations to the USU President;
G. Consider recommendations made to establish new academic programs at USU. (Recommendations for new programs will be read into the minutes at the Board meeting when they are first presented. Advice on whether or not to approve new programs will ordinarily be provided to the USU President at the next regularly scheduled Board meeting.); and
H. Perform other duties as deemed appropriate and within its Cha11er, to include (I) assessing and providing advice to the Assistant Secretary of Defense for Heal th Affairs, the Under Secretary of Defense for Personnel and Readiness, and the Secretary of Defense on the performance of the USU President; the performance of USU as an institution (including major academic programs and divisions); the well-being of USU faculty, students, and staff; the adequacy of USU financial resources and their management; and the adequacy ofUSU's physical facilities; and (2) serving as an advocate for USU and its needs.
Article V
Advisors. Advisors to the Board shall include:
A. USU deans;
B. Commanders of affiliated teaching hospitals;
C. A legal advisor (the USU General Counsel);
D. A military advisor to provide advice to the Board from an operational perspective;
3 and
E. Other individuals invited by the Board to serve in this capacity.
Article VI
Committees.
A. Designation: The Board of Regents, as a body, shall designate either standing or ad hoc committees as necessary.
B. Purpose: Board committees shall be responsible for in-depth consideration of assigned Board agenda items and/or special projects between scheduled meetings.
C. Membership: The Chair of the Board of Regents shall appoint committee members and designate their chairs. Ordinarily, at least one appointed member of the Board and at least one ex officio member of the Board will be appointed to each committee.
D. Meetings: Each committee shall meet either at the call of its chair, or at the request of any two members other than the chair. Meetings may be held in person or via conference call.
Article VII
Awards.
A. Board of Regents Awards: The Board shall annually recognize four outstanding students selected by the Dean, School of Medicine; the Dean, Graduate School of Nursing; the Associate Dean, Graduate Education; and the Executive Dean, Postgraduate Dental College, in accordance with separately established criteria.
B. Carol J. Johns, M.D. Medal: The Board shall review and approve or disapprove the Carol J. Johns, M.D. Medal recognizing an outstanding faculty member selected by the Faculty Senate in accordance with separately established criteria.
C. The Distinguished Service Award, Exceptional Service Award, and the University Medal: The Board shall review and approve or disapprove Distinguished Service and Exceptional Service awards and the University Medal.
4 Article VIII
General Procedures.
A. Regular Meetings: The Board shall hold at least four ( 4) meetings in an annual period from October 1 to September 30, or more often if the Secretary of Defense, the designee of the Secretary of Defense, or the Chair of the Board of Regents shall deem it necessary. Unless otherwise determined by the Board, meetings shall be held in the Everett Alvarez Jr. Board of Regents Conference Room at the University, 4301 Jones Bridge Road, Bethesda, MD 20814.
B. Additional Meetings: Additional meetings shall be called by the Designated Federal Officer of the Board upon the direction of the Chair of the Board of Regents, the USU President, or upon written request of three or more members of the Board. Additional meetings of the Board shall be held at such times and places as shall be specified in the notice of the meeting.
C. Notice of Meetings:
1. Notice of all meetings of the Board shall be sent by the Designated Federal Officer to each member of the Board by mail, fax, electronic mail or telephone.
2. The Designated Federal Officer shall mail a notice not less than fifteen (15) days before any regular meeting. Faxing, emailing, or telephoning a notice shall be done not less than seven (7) days before a regular meeting.
3. The recital by the Executive Secretary in the minutes that notice was given shall be sufficient evidence of the fact.
4. Public announcement of the meetings of the Board shall appear in the Federal Register as provided in the Government in the Sunshine Act. (5 U.S.C. 552b(e)(3))
D. Closure of Meetings: Meetings of the Board shall be open to the public unless a written determination is made to close all or part of a meeting in coordination with General Counsel. The determination shall cite those provisions of 5 U.S.C. 552b(c)(l) that justify closure and a summary of meeting activities shall be prepared and maintained as part of nonpublic Board of Regents files.
E. Quorum: The presence of a majority of all members of the Board will constitute a quorum of the Board. When there are no vacancies on the Board, a quorum means at least eight (8) members must be present in person or via electronic means. A member's duly designated representative, provided the designation includes a proxy, counts for purposes of a quorum.
5 F. Voting:
1. During a meeting, if a quorum is called for by a member and found not to be present, no further business may be transacted.
2. During a meeting, issues will be determined by voice balloting, unless an ind ividual member of the Board of Regents requests a written ballot.
3. The Chair, Board of Regents, is a member of the voting assembly and has the same right to vote as any other member.
4. Unless otherwise specified, a simple majority vote will determine matters of issue before the Board. In the event of a tie vote, the proposed resolution is lost.
5. At the direction of the Chair, Board of Regents, action may also be taken by a majority of the members by notation voting (that is to say by voting on material circulated to the members individually or serially, or by polling members individually or collectively by mail, telephone, fax, e-mail or a similar procedure). Such action will be reported by the Executive Secretary at the next meeting of the Board.
6. The Secretary of Defense, or the Secretary's designee, or a duly appointed representative of the Secretary's designee is authorized to vote.
7. The Surgeons General of the Uniformed Services, or their duly appointed representatives, arc authorized to vote.
8. The USU President is precluded by statute from voting.
9. Except for the USU President, individual members of the Board, to include lhe designee of the Secretary of Defense, may give proxies to their representatives or to other members of the Board of Regents (allowing them to be counted for quorum purposes and to vote) provided this is done in advance and in writing.
G. Order of Business: The order of business will be at the discretion of the Chair, Board of Regents, unless otherwise specified by the Board.
H. Rules of Order: The rules contained in the current edition of Robert's Rules of Order Newly Revised shall govern the Board in all cases in which they are applicable and in which they are not inconsistent with applicable statutes and directives, these bylaws, and any special rules the Board may adopt.
6 Article IX
Amendment and Effective Date.
A. Amendment: These bylaws may be amended at any meeting of the Board as long as each proposed amendment has been provided to the members at least 60 days before the next scheduled meeting. Amendments will take effect by the affirmative vote of two thirds (2/3) of the members present.
B. Effective Date: These bylaws are effective May 18, 2012, and supersede previously published bylaws dated February 7, 2012.
Ronald R. Blanck, D.O., Chair, Board of Regents
7
TAB 5
Meeting Calendars Board of Regents Uniformed Services University of the Health Sciences
Meeting Calendar
November 2014 December 2014 January 2015 S M T W T F S S M T W T F S S M T W T F S 1 1 2 3 4 5 6 1 2 3 2 3 4 5 6 7 8 7 8 9 10 11 12 13 4 5 6 7 8 9 10 9 10 11 12 13 14 15 14 15 16 17 18 19 20 11 12 13 14 15 16 17 16 17 18 19 20 21 22 21 22 23 24 25 26 27 18 19 20 21 22 23 24 23 24 25 26 27 28 29 28 29 30 31 25 26 27 28 29 30 31 30
February 2015 March 2015 April 2015 S M T W T F S S M T W T F S S M T W T F S 1 2 3 4 5 6 7 1 2 3 4 5 6 7 1 2 3 4 8 9 10 11 12 13 14 8 9 10 11 12 13 14 5 6 7 8 9 10 11 15 16 17 18 19 20 21 15 16 17 18 19 20 21 12 13 14 15 16 17 18 22 23 24 25 26 27 28 22 23 24 25 26 27 28 19 20 21 22 23 24 25 29 30 31 26 27 28 29 30
May 2015 June 2015 July 2015 S M T W T F S S M T W T F S S M T W T F S 1 2 1 2 3 4 5 6 1 2 3 4 3 4 5 6 7 8 9 7 8 9 10 11 12 13 5 6 7 8 9 10 11 10 11 12 13 14 15 16 14 15 16 17 18 19 20 12 13 14 15 16 17 18 17 18 19 20 21 22 23 21 22 23 24 25 26 27 19 20 21 22 23 24 25 24 25 26 27 28 29 30 28 29 30 26 27 28 29 30 31 31
August 2015 September 2015 October 2015 S M T W T F S S M T W T F S S M T W T F S 1 1 2 3 4 5 1 2 3 2 3 4 5 6 7 8 6 7 8 9 10 11 12 4 5 6 7 8 9 10 9 10 11 12 13 14 15 13 14 15 16 17 18 19 11 12 13 14 15 16 17 16 17 18 19 20 21 22 20 21 22 23 24 25 26 18 19 20 21 22 23 24 23 24 25 26 27 28 29 27 28 29 30 25 26 27 28 29 30 31 30 31
October 2014 Page 1/2
Board of Regents Uniformed Services University of the Health Sciences
Meeting Calendar
November 2015 December 2015 January 2016 S M T W T F S S M T W T F S S M T W T F S 1 2 3 4 5 6 7 1 2 3 4 5 1 2 8 9 10 11 12 13 14 6 7 8 9 10 11 12 3 4 5 6 7 8 9 15 16 17 18 19 20 21 13 14 15 16 17 18 19 10 11 12 13 14 15 16 22 23 24 25 26 27 28 20 21 22 23 24 25 26 17 18 19 20 21 22 23 29 30 27 28 29 30 31 24 25 26 27 28 29 30 31
February 2016 March 2016 April 2016 S M T W T F S S M T W T F S S M T W T F S 1 2 3 4 5 6 1 2 3 4 5 1 2 7 8 9 10 11 12 13 6 7 8 9 10 11 12 3 4 5 6 7 8 9 14 15 16 17 18 19 20 13 14 15 16 17 18 19 10 11 12 13 14 15 16 21 22 23 24 25 26 27 20 21 22 23 24 25 26 17 18 19 20 21 22 23 28 29 27 28 29 30 31 24 25 26 27 28 29 30
May 2016 June 2016 July 2016 S M T W T F S S M T W T F S S M T W T F S 1 2 3 4 5 6 7 1 2 3 4 1 2 8 9 10 11 12 13 14 5 6 7 8 9 10 11 3 4 5 6 7 8 9 15 16 17 18 19 20 21 12 13 14 15 16 17 18 10 11 12 13 14 15 16 22 23 24 25 26 27 28 19 20 21 22 23 24 25 17 18 19 20 21 22 23 29 30 31 26 27 28 29 30 24 25 26 27 28 29 30 31
August 2016 September 2016 October 2016 S M T W T F S S M T W T F S S M T W T F S 1 2 3 4 5 6 1 2 3 1 7 8 9 10 11 12 13 4 5 6 7 8 9 10 2 3 4 5 6 7 8 14 15 16 17 18 19 20 11 12 13 14 15 16 17 9 10 11 12 13 14 15 21 22 23 24 25 26 27 18 19 20 21 22 23 24 16 17 18 19 20 21 22 28 29 30 31 25 26 27 28 29 30 23 24 25 26 27 28 29 30 31
October 2014 Page 2/2
TAB 6
Chair’s Opening Comments Chair’s Opening Comments
• Welcome to new Board member, Senator Charles Robb
• Next meeting - Winter 2015 o February 2-3, 2015 o At USU
• 2015 Board off site meeting
• Liaison Committee on Medical Education (LCME) site visit o October 25-28, 2015
• Award approval process update
• February 2015 Board review of the Charter, Membership Balance Plan and Bylaws
• Faculty packet due dates (Attachment 1)
• Closed session this afternoon o personnel actions o active investigations
• USU’s mission, vision and values (Attachment 2)
October 2014
Attachment 1
USU BOARD OF REGENTS
Faculty Packet Due Dates
Board Meeting Board Due Date CHR Due Date 3 February 2015 5 January 2015 15 December 2014 15 May 2015 16 April 2015 26 March 2015 4 August 2015 6 July 2015 15 June 2015 3 November 2015 5 October 2015 14 September 2015 2 February 2016 4 January 2016 14 December 2016 20 May 2016 21 April 2016 31 March 2015 2 August 2016 1 July 2016 10 June 2016
October 2014 Attachment 2
Mission
The mission of the Uniformed Services University of Health Sciences is to train, educate and prepare uniformed services health professionals, officers and leaders to directly support the Military Health System, the National Security and National Defense Strategies of the United States and the readiness of our Armed Forces.
Vision
By the end of 2015, the Uniformed Services University of the Health Sciences, recognized as the preeminent educational institution for the creation of career uniformed services health professionals and leaders prepared to serve the nation wherever and whenever duty calls, will be a central hub for military-related health education and research, and the nation’s center of excellence for the health dimensions of our national security strategies. USU will insure that each graduate is prepared with an outstanding health education, inter-professional health training, and a deep and abiding commitment to selfless service and responsible leadership, the military ethos and the security of the United States.
Values
The University is unique within the Department of Defense and, indeed, across the entire health education and training community. We serve one of our nation’s most values-centric and trusted institutions: the Armed Forces of the United States. Our institutional values reflect the community we serve and include:
Courage and Integrity We foster a culture of academic, physical and moral courage in all our graduates, faculty and leaders, and we are uncompromising in our adherence to the highest standards of intellectual and personal integrity.
Innovation As an academic institution, our faculty and researchers continuously and aggressively push back the frontiers of knowledge in areas crucial to America’s national security.
Caring We foster an atmosphere of caring, mutual respect, courtesy, pride in work and combined military and academic professional development.
Communication We interact and share information in a timely manner with openness, candor and sensitivity.
Scholarship We are committed to academic freedom as fundamental to the advancement of knowledge and a lifetime of learning.
Service We are committed to serving those who defend the nation, and we are sensitive to the unique role that our Soldiers, Sailors, Airmen and Marines play in our national security.
Collaboration and Teamwork We value the contributions of each member of our community and work to achieve an environment characterized by cooperation, collegiality, tolerance, mutual respect and an appreciation of diversity, and we facilitate cooperation and collaboration in our science, educational, methodologies, research and leadership.
TAB 7
Board of Regents Meeting Minutes: August 5, 2014 Minutes of the Board of Regents, Uniformed Services University of the Health Sciences
Meeting No. 188 August 5, 2014
The Board of Regents, Uniformed Services University of the Health Sciences met on August 5, 2014, at the Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Everett R. Alvarez, Jr. Board of Regents Room (D3001 ), Bethesda, Maryland. The meeting date and agenda items were published in the Federal Register and each Regent was duly notified prior to the meeting. The Board Executive Secretary, Jeffrey L. Longacre, M.D., was present during the meeting along with the Designated Federal Officer (DFO), Mrs. Jennifer K. Nuetzi James. The DFO called the meeting to order at 8:05 a.m. Members and advisors listed below were in attendance:
Board Members
Sheila P. Burke, M.P.A., Member Otis W. Brawley, M.D., Member GEN Ronald H. Griffith, USA (Ret), Member Michael M.E. Johns, M.D., (Acting) Chair Gail R. Wilensky, Ph.D., Member Jonathan Woodson, M.D., Assistant Secretary of Defense for Health Affairs Charles L. Rice, M.D., President, USU MG Thomas Tempel, DC, USA, Representing the Surgeon General of the U.S. Army RADM Forrest Faison, MC, USN, Representing the Surgeon General of the U.S. Navy Brig Gen Gretchen Dunkelberger, USAF, NC, Representing the Surgeon General of the U.S. Air Force RADM Boris D. Lushniak, USPHS, Acting Surgeon General of the U.S.
Advisors to the Board
Gen Thomas R. Morgan, USMC (Ret), Military Advisor to the Board Brian Reamy, M.D., Representing the Dean, F. Edward Hebert School of Medicine, USU Ada Sue Hinshaw, Ph.D., R.N., Dean, Daniel K. Inouye Graduate School of Nursing, USU Patrick D. Sculley, D.D.S., M.A., Executive Dean, Postgraduate Dental College, USU Col L. Andrew Huff, USAF, MC, Director, Armed Forces Radiobiology Research Institute, USU RDML Raquel C. Bono, MC, USN, Commander, Defense Health Agency National Capital Region Medical Directorate BG Jeffrey B. Clark, MC, USA, Director, Walter Reed National Military Medical Center Joshua Girton, J.D., Legal Advisor to the Board of Regents, USU
OPENING COMMENTS In his opening comments, Dr. Johns noted that he is serving as acting Chair for the Board of Regents and welcomed the new representatives attending on behalf of others. The following points were included in Dr. Johns' remarks: • A copy of the letter that the Board sent to the Under Secretary of Defense is included at Tab 7 • Member renewals and a new member appointment were approved. Senator Charles Robb will be joining the board in October. Dr. Woodson noted the positive trend in responsiveness and action within the FACA office. • The fall Board of Regents meeting will be in Hershey, Pennsylvania at the Hershey Lodge. Tuesday afternoon, October 14, 2014 will be the meeting of record. Dr. Longacre elaborated on the general schedule and optional activity of the USU Bushmaster field exercise. It was noted that the preparatory sessions will be combined in to Tuesday afternoon. • The award approval process was addressed and it was noted that the board acts in an advisory capacity. The Board's role is to make recommendations to the university president for action. • Dr. Johns addressed USU faculty tardiness in the packet submissions to the Board. Dr. Longacre referred to Attachment 1 and the noted due dates adding that deadlines have to be met to comply with F ACA regulations. • It was noted that a closed session will occur later that morning. • Dr. Johns read a thank you letter addressed to the USU Board Chair from Dean Hinshaw that was submitted the afternoon before the Board meeting and was included for review as a handout. Dr. Johns noted the exquisite leadership by the Graduate School of Nursing Dean. • Dr. Johns yielded time to Mr. Kaar, USU General Counsel, to provide an ethics refresher. Mr. Kaar referenced Special Government Employees (handout in folder, provided to the Board) and the rules that apply to those employees. It was noted that representation was the key point and that SGE's cannot represent a third party to a government official. Dr. Wilensky sought clarification by asking if members are still prohibited even if there is no cost involved. Mr. Kaar confirmed that it doesn't matter if there is a cost or not. Dr. Brawley asked a question regarding communication with a Congressman. Mr. Kaar asked if the communication would occur on government time and noted that if a trip is arranged specifically to do an extracurricular activity then it would be a problem. Dr. Johns sought further clarification regarding paid Board time. Mr. Kaar stated that once the meeting is adjourned then members are off the clock.
MATTERS OF GENERAL CONSENT Dr. Johns presented the matters of general consent listed below. • The board meeting calendars on Tab 5 • Minutes of the May 16, 2014, meeting. Dr. Johns recused himself from voting on the May meeting minutes due to his absence at that meeting. o Advanced electronic approval of the May 16, 2014 meeting minutes was received from Drs. Blanck, Debas and Moritsugu.
Upon motion duly made and seconded, the Board Vote by voice vote: Approved the matters of general consent as presented. Dr. Johns noted that Dr. Blanck will sign the May meeting minutes.
Board of Regents, USU, August 5. 2014 Page 2/ 10 PRESIDENT'S REPORT Dr. Rice noted the upcoming retirement of Dr. Hinshaw and the presentation of the University Medal and the Order of Military Medical Merit. The points below summarize the additional items discussed by Dr. Rice. • Dr. Bibb will be moving to Wichita State University to serve as the Dean of the College of Health Professions. • The Enlisted to Medical Doctor Preparatory Program continues to gain momentum with both Air Force and Army students already selected. Dr. Rice noted that he was looking forward to the Navy's participation next year. He noted CSM (Ret) Althea Green Dixon has taken the lead on this project. Dr. Reamy noted the outstanding quality of the candidates. Dr. Wilensky asked for the educational background of the candidates. Dr. Rice stated the candidates have bachelor's degrees in fields other than the sciences. An agreement with George Mason University allows the students to complete their remaining preparatory (hard science) requirements. Students are typically in a remote location as active duty Service members and have completed degrees online. Dr. Rice stated this program will be ideally suited to prepare these selected students, who already possess the drive and intellect, to succeed. A slightly higher failure rate is to be expected which would ensure the net was cast wide enough to get all potential candidates. Dr. Reamy noted the medical college admissions test changes that are coming in 2015 and this program might better prepare students. Dr. Wilensky enthusiastically agreed and voiced her support for the program. Dr. Rice expressed thanks to the Services for making this initiative happen. GEN Griffith asked about the minority composition of this group. Dr. Reamy noted 6 of the 10 are underrepresented minorities. GEN Morgan asked about the students' relationship with USU and mentoring for the students. Dr. Rice noted that each student will have a mentor and the mentor will potentially be a prior enlisted individual. Col Kevin Glasz noted that the students are assigned to the brigade and Dr. Rice noted that the students will need to continue to meet military requirements. Dr. Longacre mentioned that George Mason is embracing this program and they are also providing academic mentors. The students will have support here at USU and at George Mason. Dr. Reamy reiterated the close involvement between the pre-med advisor at George Mason and the USU Assistant Dean for Admissions. Dr. Rice shared that a request for proposal (RFP) was advertised and the George Mason proposal was deemed the strongest. The other RFP submissions were also solid but George Mason received the contract. • An update was provided on the electronic Registrar system and USU IT involvement. The system should be operating by fall and have full capability in 12-15 months. A progress report will be provided to Middle States Commission on Higher Education in September. • The Naval Academy asked for USU clinical support on I-day (Indoctrination Day). Although the logistics didn't work out this year, there are plans and interest to provide support in the future. • Dr. Rice noted Dr. Woodson's establishment of the Innovation Cell at USU and the spectrum of activities it will encompass. Dr. Rice noted that a 100% success rate will be a challenge.
Board of Regents, USU, August 5, 2014 Page 3'10 • The Consortium of Universities of the Washington Metropolitan Area was described and noted to include many local institutions as members. USU is exploring a membership which would allow the students of the member universities to enroll in classes at the other member institutions for academic credit. There would be a notable benefit especially for USU PhD students. • Dr. Rice mentioned the FTE Cap that will be a challenge for a number of years and over the next few years the FTE cap ceiling will drop, which will continue to be an increasing challenge. • A command climate survey will take place in late summer, early fall.
BOARD ACTIONS Degree Granting - Graduate Education Dr. Mueller presented for certification six candidates to receive the graduate degree of Doctor of Philosophy (two candidates in the Emerging and Infectious Diseases Graduate Program, two candidates in the Medical and Clinical Psychology Graduate Program, one candidate in the Molecular and Cell Biology Graduate Program and one candidate in the Preventive Medicine and Biometrics Graduate Program). Dr. Mueller noted the error in listing Ms. Genevieve Sullivan's degree as Medical and Clinical Psychology Graduate Program, rather than Molecular and Cell Biology.
Upon motion duly made and seconded, the Board Vote by voice vote: Concurred with the recommendations as presented by Dr. Mueller and recommended that the president confer the degrees as stated upon each of the six candidates.
Dr. Rice noted the military relevance of each of the graduate education degree candidates' research.
Faculty Appointments and Promotions - School of Medicine Dr. Reamy presented the recommendations made by the School of Medicine Committee on Appointments, Promotion and Tenure at a meeting held on June 27, 2014. Thirty-three individuals were recommended for faculty appointments or promotion. Dr. Reamy noted the amount of national faculty who teach USU students across the country. Dr. Reamy also noted three additional faculty recommendations that are included as a handout. These three additions are surgeons that were duly promoted but their information was inadvertently delayed in administrative processing.
Upon motion duly made and seconded, the Board Vote by voice voted: Concurred with the recommendations as presented by Dr. Reamy and recommended that the president implement the actions.
Dr. Rice noted the great strides that have been made in the appointment and promotion process by Drs. Reamy and Sculley.
Faculty Appointments and Promotions - Postgraduate Dental College Dean Sculley presented the recommendations made by the Postgraduate Dental College Committee on Appointments, Promotion and Tenure at a meeting held on July 7, 2014. Two individuals were recommended for faculty appointments or promotion.
Board of Regents, USU. August 5. 2014 Page 4/ 10 Upon motion duly made and seconded, the Board Vote by voice voted: Concurred with the recommendations as presented by Dean Sculley . and recommended that the president implement the actions.
Awards and Honors Dean Sculley presented the recommendation by the Names and Honors Committee for Colonel George Barber to receive the Exceptional Service Award for his three years of distinguished service to the University as the Program Director for the Advanced Education in General Dentistry-2 Progran1 at Ft. Bragg, NC.
Upon motion duly made and seconded, the Board Vote by voice vote: Concurred with the recommendation as presented by Dean Sculley and recommended that the president implement the actions.
ACADEMICS PREPARA TOR Y SESSION A review of the Academics Preparatory session was provided by Dr. Johns. The following points were included in Dr. Johns' discussion: • The report of the School of Medicine (SOM) notes important accomplishments including the increase of underrepresented minorities to 10.5% from 2% last year, a significant change. The LCME peer review of teaching programs was put in place. There was an extensive review of the appointment and promotion guidelines, most significantly the extension of tenure from six years to nine years. There will be reviews and guidance every three years. • Dr. Rice asked for elaboration on the class statistics. o Dr. Reamy noted the increase to 10.5% of underrepresented minority students. o First generation college students are 19% of the class. o Prior enlisted students are 10% of the class. o Service academy enrollees are 14% of the class. o These groups of students above have been an initiative for the school and the increasing numbers speak to the success in reaching these students. Dr. Reamy noted that the outreach to students occurred through a variety of methods and even after they have been accepted. Dr. Wilensky asked about which outreach strategies have worked the best. Dr. Reamy noted that there have been a variety of strategies implemented and Dr. Saguil has published a paper on these strategies. Dr. Saguil and Dr. Kellermann electronically published a paper about the first generation college students noting most go through community college. • The Graduate Education Office has had some office changes to include Dr. Greg Mueller assuming the duties as Acting Dean for Graduate Education. Dr. Mueller addressed the issue of stipend support and he reviewed the strong collaboration between the School of Medicine, The Henry M. Jackson Foundation and the Graduate Education Office. Dr. Mueller also noted the challenges of the DoD restrictions on international applicants, restricting students to only those with a bachelor's degree from an accredited program in the U.S. or Canada. • The Graduate School of Nursing (GSN) reported that Dr. Marguerite Littleton-Kearney will serve as Acting Dean of the Graduate School of Nursing, when Dean Hinshaw steps down. The Health Resource and Services Administration (HRSA) initiative was
Board of Regents, USU. August 5. 2014 Page 5/ 10 reviewed. Dr. Penny Pierce will be the director of the HRSA collaboration. A summary of Dean Hinshaw's visit with congressional staff and the Federal Nursing Service Counsel was reviewed. The GSN inter-professional initiatives with the SOM and Postgraduate Dental College (PDC) were reviewed. • Dr. Sculley's report for the PDC recapped the five dental college graduations. It was noted that the new dental program at Fort Gordon had matriculants on July 1. Representatives from the Tri-Service Center for Oral Health Studies are working with the military populations at Fort Bragg and Lackland on a pilot study. Inter-professional assistance is being received from the GSN to create an enhanced research environment. Dr. Sculley reviewed the San Antonio Uniformed Services Health Education Consortium initiative to potentially partner with USU in graduate medical education. The Military Training Network had an annual meeting in San Antonio. Dr. Sculley provided a Medical Education and Training Campus update pointing out that the charter is out for signature. • Dr. Auster's report for the Faculty Senate noted the travel restrictions currently in place and while funds are available they cannot be used. Dr. Woodson noted that over the last couple of years with sequestration, things were complicated and now there is work to push the travel approval process to the correct level and separate conference issues. Dr. Woodson is hopeful for a resolution in the near future. Dr. Auster noted that increasing involvement of faculty in the University processes has been a positive development. Dr. Johns noted the comparability report at the end of the Faculty Senate report. • The Vice President for Research report noted the indirect cost and under recovery challenge. The ability to accept external foundation awards has become a challenge and faculty are pressured to find funding through other sources. The indirect costs paid by grants can sometimes be zero and there is no immediate solution. There is no ability at USU to absorb the indirect costs as might be the case at a civilian institution. Another effort to streamline the grant submission process was noted. Dr. Rice pointed out the interest of the National Heart Lung and Blood Institute in creating a collaboration with USU, similar to the current collaboration of the National Institute of Allergy and Infectious Disease and the USU Center for Neuroscience and Regenerative Medicine. Dr. Rice and the Director, National Institute of Minority Health and Health Disparities are meeting with Dr. Woodson to discuss a health disparities initiative. Dr. Woodson noted that the vision for moving the MI IS forward involves a new focus and they are interested in setting up a cell of folks that can serve a purpose within the MHS to create a synergy that would be beneficial to assist with modernization efforts. Dr. Johns noted the importance of health data and current efforts in academia to use this data. Dr. Woodson noted that with the enhanced multi-service market and integrated healthcare system, the need to be competitive. RADM Faison noted that there is an extraordinary amount of data on MHS patients and they are trying to build computing power and data analysis power. The super computers are being investigated to research risk factors and they are also looking at increasing transparency for increased clinical trials. A large investment in the IT infrastructure will be needed. Dr. Rice noted the MPH grad students that are looking for projects and the University has statutory authority to contract with a non profit. Dr. Wilensky noted the access to data will be critical and the help to the military will be tremendous. Ms. Burke noted that the information could bring in some revenue if there is authority to charge for that information. Dr. Woodson noted the increased
Board of Regents, US U, August 5.101.t Page 6/J O relationshjp with health leaders. This is an area (information/analytics) where the MHS can lead the nation. This is a two-sided effort, academics to improve healthcare and moving those findings in to practice. Dr. Woodson noted his early efforts to do studies and put them in to action.
FINANCE AND ADMINISTRATION PREPA RATORY SESSION Dr. Brawley provided a summary of the reports reviewed during the Finance and Admirustration Preparatory session. • Mr. Rice was unable to attend and Ms. Arta Mahboubi attended as ms representative. Bridge funding for the Enlisted to Medical Degree Preparatory Program was noted. The loss of FTE's as mentioned earlier by Dr. Rice, will be a tremendous strain. Financially, the school is meeting its core missions, but the current pace is not sustainable. The good condition of the physical infrastructure was reviewed; these items tend to be ignored when money is tight so the school should be commended. • The Brigade report noted a climate assessment that will soon be coming out and they also noted that the replacement for the open Marine Corps vacancy will be filled soon. The major concern is that there will be a loss of personnel at the military ranks of 0 -3 and 0- 4 levels. The Brigade also provided updates on the University strategic framework. Col Glasz has been working on a professional development series with amazing speakers. There has been significant discussion regarding officer trairung and the senior enlisted staff at the University that help with customs and courtesies. There is a need to ensure that officers complete the proper training. • Mr. Kaar noted the challenges of low staff in the OGC office but they are finally reaching full staff with a deputy general counsel joining the staff.
GEN Griffith commented that if one ignores infrastructure a sigruficant backlog will result. It's easy to divert money to trairung but the university is doing a great job.
Dr. Woodson commented that it is essential to maintain excellence in officersrup for both the University and the MHS.
Dr. Brawley noted that about 30-40 students per year miss training for a variety of administrative reasons. It was noted that the corps here at the University surrounds and advises these individuals and helps them to succeed.
BREAK OCCURRED from 9:34am - 9:50am
USU INSPECTOR GENERAL'S REPORT Mr. Henske noted that this is a status update on the Inspector General (IG) office. Mr. Henske noted the draft policy which was devised from the DoD and the Surgeon General offices using the applicable academic information. The reporting chain and office functions were reviewed. For inquiries, comments, et cetera, the Ethics Point (hotline) is used, which offers complete anonymity. When a breach is reported it goes directly to the USU IG office and then Dr. Rice. Within I 0 days a response is provided to the person. Since the program began, five years ago, there have been 213 inquiries (mostly environmental). The next office focus is the wrustleblower protection program. The USU IG office maintains all coordination for external agencies and for the Surgeon General IO offices. This office is also the focal point for the GAO.
Board of Regents, USU, August 5, 201 -+ Page 7110 Dr. Rice expressed thanks to GEN Griffith for his recommendation to have the office and to Mr. Henske for taking this tasker. Dr. Rice noted he was pleased with the functioning of the office. GEN Griffith noted the importance of the office and asked how individuals would know about the office. Dr. Rice noted that he includes information during his meet and greet session for new staff and it is mentioned in the President's Open Door policy. Ms. Burke asked what happens if the issue is the president. Mr. Henske said that nothing prohibits the IG (including one focused on the president) from beginning an investigation. Mr. Henske would have to send that sort of investigation if it were to ever occur to the next level.
MATRICULATION AND DECLINATION RATES Dr. Rean1y presented the matriculation and declination info1mation due to a previous Board request. He noted a 61 % student acceptance rate and on the second page he noted comparative numbers and was interested in comments from the Board. He also noted that schools with most rejections of acceptance would rank high on the U S. News & World Report. Dr. Wilensky noted that students have self-selection and that high acceptance rates might be because of limited options available. Dr. Reamy noted that USU is very comfortable with our acceptance rate. Dr. Johns noted that it can also be tracked if there are dual acceptances and where the student ultimately goes. Rates give a sense of the pool with which one competes. Dr. Reamy pointed out that USU acceptances are offered contingent on passing medical qualifications. RADM Lushniak asked how much information regarding medical stipulations are provided in advance. Dr. Reamy said that for applicants invited to interview, those requirements are described in detail on that day they are here.
FACULTY APPOINTMENT CVs Dr. Reamy noted that the second item for him to discuss was the faculty dissatisfaction in having to present the Board with an abbreviated CV. Faculty are busy and we ask them to submit a two-page CV for the Board. The two-page CV was meant as a quick summary for the use of the Board. Dr. Reamy and Dr. Sculley are looking to eliminate that two-page CV. Dr. Brawley notes that faculty have to maintain a two-page abbreviated (NIH) CV. Dr. Reamy notes that the NIH one would be acceptable and when previously brought to the Board it seemed that no one looks at the CV's. Dr. Brawley mentioned that maybe the Board would accept an NIH CV. Dr. Johns noted that the Board role is governance and not management. The appointment and promotion process is already in place and the Board responsibility is to assure that the approved process is followed. Dr. Johns noted that often a person who does not have expertise looking at the CV cannot adequately review the CV and judge the quality of the science or research. His view of the Board' s primary role is to make sure the appointment and promotion process is clear and in place and is followed. It was noted that some faculty don't do the NIH resume. Ms. Burke noted that the Board trusts the process and that anyone on faculty has to do this, i.e., when giving a speech there are similar requirements. Dr. Wilensky agreed with Ms. Burke and noted that the Board is providing oversight. Dr. Wilensky noted that the Boards role is to make sure that processes are in place to provide good outcomes. Dr. Johns noted, if the faculty are going to post CV s, then maybe the Board could easily access them or they could be scanned to members. Dr. Wilensky likes the ability to have a quick read of the person corning on as faculty. Dr. Sculley mentioned that there is a time element involved to get the book ready and then have it presented to the Board. Dr. Wilensky noted that the process needs to be revised if it is taking too long. Dr. Johns asks if there is a way to post the full CV on a secure web site so the
Board of Regents, USU. August 5, 2014 Page 8/10 Board could access. There should also be training for the faculty on how to write a good resume. The Board will want to read the resume of a new individual and not see their full CV. Dr. Brawley referred to maintaining an NIH CV and the benefits. Dr. Rice would like to put together a small working group and try to streamline the process, and put up a secure website and at the October meeting he will come back to the board with suggestions to both streamline the process for the Board and streamline the process for the faculty. The Board agreed with Dr. Rice's plan.
NATIONAL CAPITAL REGION (NCR) UPDATE RDML Bono noted the 5-year business plan and three initiatives. The estimated 5-year net savings represents half of all the anticipated savings. There are six enhanced multi-service markets in the MHS and each region represents 50% of costs of the MHS indirect system. There are over 450,000 eligible beneficiaries in the NCR. The NCR has an opportunity for savings that none of the other markets have. There is hope to increase the enrollment over the 5-year period. Pre and post BRAC, half of the eligible enrollees are in MTFs. It was noted that Johns Hopkins only enrolls 7% of the eligible population in the area. In addition, Hopkins has a controlled growth (10% cap of previous enrollment). RDML Bono noted that they are partnering with Hopkins to see how they can take care of the patients better. Dr. Wilensky asked for elaboration on the Hopkins cap. RDML Bono noted that is how Hopkins has it written in to their program, that they can only grow at 10% per year. It was noted that 32% of patients pre-BRAC were not enrolled in any MTF and now that number is down to 31 % and that is the opportunity for growth. Deferrals were defined as those patient referrals that can't be cared for at the MTF and are deferred to the network. For example, in May, 18% of the patients were going to the network. Ms. Burke asked who the deferral patients are. It was noted that they are most notably orthopedics and general pediatrics. The numbers are based on military providers. Gastroenterology has similar trends. RDML Bono would like to get to a 40% MGMA median. The current state of GME is doing very well and has achieved maximum accreditation. RDML Bono noted that there are no programs on probation yet two programs were cited for concerns. The challenges are access to patients and index cases needed for training. There is an opportunity to get patients not currently in the market and an opportunity to partner with Hopkins. The more important thing is to work to partner within the market. There is compelling leadership of the other MTFs in the market. RDML Bono noted the need to go where the patients are, instead of allowing them to go out to the network or requiring them to go to Walter Reed if it is considerable distance for the patient. Because of the current governance structure, the NCR can now influence decision making versus the previous silo approach. GEN Griffith notes that more physicians are needed where the patients are, to meet the objective. The one team approach is spreading to the entire area. The physical therapy patients were recently addressed as a market, not as an individual MTF. Ms. Burke asked about labeling (Ex. Sibley Hospital is now Hopkins). Is there capacity at the new location where the physicians would go? RDML Bono noted that parameters are monitored frequently. Dr. Johns noted that people will travel for the brand. RDML Bono noted the educational efforts that will continue at print media and they will address their presence in the market. Gen Morgan asked where the AF active duty and retired military go for care. Brig Gen Dunkelberger noted they receive care at Walter Reed. RADM Faison asked about the workload. RDML Bono said any case is an index case. RADM Faison noted that the RRCs are looking at specific case mix and wondered will we get the right workload to support the GME requirements? BG Clark noted that the VA is a key piece and they are also working with the Armed Forces Retirement Home which both provide routine cases.
Board of Regents, USU, August 5. 20 14 Page 9/10 RADM Faison asked about the competition between residency programs and how do we maintain those cases. RDML Bono noted they are trying to shorten the access route and bring in complex cases from the VA. Dr. Brawley noted that use of robotics now has created young surgeons that don't know how to operate. RDML Bono noted that robotics care has not shown an increased value or advantage. It is an emerging technology and military health has been proud of using emerging technology. Dr. Brawley noted that academic centers are trying to retain older staff and have them intensively train young surgeons. RDML Bono noted that older faculty do stay longer to train young doctors. Dr. Rke noted that RDML Bono and BG Clark are making clinical success and this is vital to the University's educational program. Or. Rice also noted another access challenge, the perimeter of the facility. which is controlled by Naval Support Activity Bethesda (NSAB). Parking is a particular challenge and NSAB is aware of the challenge.
ADJOURNMENT There being no further business on the agenda. Dr. Johns asked if there was any further information to be brought forward, then adjourned the open portion of the meeting at 10:56 a.m.
SUBMITTED: APPROVED:
y L. I.: ngacre, M.D. Michael M.E. Johns, M.D. Executive Secretary, Board of Regents (Acting) Chair, Board of Regents
Prepared by: Mrs. Jennifer Nuetzi James, Designated Federal Officer
Board of Regents, USU. August 5, 2014 Page 10/ 10
TAB 8
Declaration of Board Actions UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301JONESB~DGEROAD BETHESDA, MARYLAND 20814-471 2 http:l/www.usuhs.ml1
BOARD OF REGENTS
September 22, 2014
MEMORANDUM FOR CHAIR, BOARD OF REGENTS
SUBJECT: Record of Board Actions
According to the Board of Regents Bylaws, action may be taken by polling members individually or collectively by telephone, fax or e-mail. Any such action is then reported to the Board at an open meeting and recorded appropriately in the minutes of record.
Since the August 5, 2014 meeting, the Board of Regents concurred with the following actions and recommended that the President, USU take action:
• Faculty primary appointment for Laura Taylor, PhD, to the Daniel K. Inouye Graduate School of Nursing • Faculty Emeritus appointment for Ada Sue Hinshaw, PhD, RN, to the Daniel K. Inouye Graduate School of Nursing
Learning to Care far Those in H arm's Way
TAB 9
Degree Granting: School of Medicine Graduate Programs
Recommended Graduate Degrees - School of Medicine October 2014
Tab 10 Anita Marinelli Doctor of Philosophy Emerging Infectious Diseases Graduate Program
Tab 11 LTC Mark Smith Doctor of Philosophy Emerging Infectious Diseases Graduate Program
Tab 12 Tonia Zangari Doctor of Philosophy Emerging Infectious Diseases Graduate Program
Tab 13 David Chang Doctor of Philosophy Molecular and Cell Biology Graduate Program
Tab 14 Bandana-Ajay Vishwakarma Doctor of Philosophy Molecular and Cell Biology Graduate Program
Tab 15 Trevor Logan Doctor of Philosophy Neuroscience Graduate Program
Tab 16 Omni Cassidy Master of Science Department of Medical and Clinical Psychology
Tab 17 CPT Sarah McCreight Master of Science Department of Medical and Clinical Psychology
Tab 18 CPT Matthew Moosey Master of Science Department of Medical and Clinical Psychology
TAB 10
Degree Granting: School of Medicine Graduate Programs
Anita Marinelli
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September 2. 2014 I MEMORANDUM FOR BOARD OF REGENTS l? _ Through: Charles L. Rice. M.D .. President ~~
SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for ce1tification to receive the Doctor of Philosophy effective upon your approval:
Anita Marin elli
DOCTOR OF PHILOSOPHY
Emerging Infectious Diseases Graduate Program
Attached is the candidate·s ce1tification ol successlul completion of the Final Examination. Also attached are the Dissertation Approval Fann. certification of authorized use of copyrighted materials. Thesis Abstract. Thesis Title Page. and Curriculum Vitae.
~~ "'""----C1 (c, {1l( Arthur L. ellcnnann. MD. MPH Dean. USU. School of Medicine
Attachments: As stated
Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Ro ad, Bethesda, MD 20814
FINAL EXAM INA TION/PRIV ATE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE EMERGING lNFECTlOUS DISEASES GRADUATE PROGRAM
Name of Student: Anita Marinelli
Date of Examination: July 2, 2014
Time: I O:OOam
Place: 84004
DECISION OF EXAMINA TJON COMMITTEE MEMBERS:
PASS FAIL t7" Dr. Anthony T. Maurelli DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY C-00 3?&~ ~
Dr. Ann E. Jerse DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY j
~
J Dr. rk . S 1rtliff UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE Committee Member
Gregory P. Mueller, Ph.D., Associate Dean (Acting II www.usuhs.mil/graded II [email protected] Toll Free: 800-772-1747 Commercial : 301-295-3913 I 9474 DSN : 295-9474 I Fax: 301 -295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
DISSERTATION APPROVAL FOR THE DEGREE OF DOCTOR OF PH ILOSO PHY rN THE EMERGING NFECTIOUS DISEASES GRADUATE PROGRAM
Title of Dissertation: "Examination of the Role of Secretory Leukocyte Protease Inhibitor (SLPI) During Gonococcal Infection"
Name of Candidate: Anita Marinelli Doctor of Philosophy Degree July 2, 2014
DISSERT ATIO AND ABSTRACT APPROVED:
DATE:
0-1--10-/y Dr. Anthony T. Maurel Ii DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Committe7 Chairperson 0.oi r '--?4:?{ ?ol-!C/ Dr. Ann E. Jerse DEP~ENT OF MICROBIOLOGY AND IMMUNOLOGY Disse atio Advisor ~ ~L1 ~~ ~ 7/1v/
Committee Member
. hi1tliff Y OF MARYLAND SCHOOL OF MED£CrNE Committee Member
Gregory P. Mueller, Ph .D., Associate Dean (Acting www.usuhs.m1l/ graded [email protected] Toll Free 800·772· 1747 Commercial : 301·295·3913 / 9474 DSN: 295 ·9474 Fax: 301·295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:
"Examination of the role of Secretory Protease Leukocyte Inhibitor (SLPI) during gonococcal colonization" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
Emerging Infectious Disease Program Department of Microbiology and Immunology Uniformed Services University Date 07/16/2014 ABSTRACT
Title of Dissertation:
Examination of the role of Secretory Leukocyte Protease Inhibitor (SLPI) during gonococcal infection
Anita Marinelli, Doctor of Philosophy, 2014
Thesis directed by:
Ann E. Jerse, PhD
Professor, Department of Microbiology and Immunology
Neisseria gonorrhoeae is a human-restricted pathogen that has evolved several mechanisms to evade host innate defenses. Secretory leukocyte protease inhibitor (SLPI) is an antimicrobial and anti-inflammatory peptide present in mucosa} secretions. Here we show that wild-type N. gonorrhoeae strains are differentially susceptible to SLPI in vitro. The observed strain variability could not be explained by differences in the expression of the phase-variable opacity proteins as suggested by a recent study, or by differences in the expression of the
MtrCDE active efflux pump, which expels other antimicrobial peptides. To f111ther examine the interplay between N. gonorrhoeae and SLPI and to test the relevance of SLPI during gonococcal infection in vivo, we measured expression of SLPI in experimentally infected female mice via qRT-PCR and ELISA and studied the impact of SLPI on gonococcal colonization in SLPI deficient mice. In BALB/c mice, increased SLPI expression occurred on day I of infection, followed by down-regulation at time points that coincided with a neutrophil influx. Strikingly, infected C57BL/6 mice, which do not mount a pro-inflammatory response to N gonorrhoeae, showed increased SLPI expression that was sustained over time. This differential expression pattern however, did not occur at the protein level, as the concentration of SLPI in vaginal lavages remained constant despite the presence of infection or inflammation. Furthermore, SLPI deficient mice cleared infection similarly to wild-type mice, suggesting that, despite being susceptible to SLPl in vitro, N gonorrhoeae has the ability to protect against SLPI bactericidal activity in vivo. The analysis of a pro-inflammatory cytokine panel in SLPI-deficient mice revealed no differences in the inflammatory response to gonococcal infection compared to wild type mice. Taken together, the results of this dissertation work indicate that SLPI is bactericidal against the gonococcus in vitro, but its effects in vivo are impaired by the low concentrations present in the lower female reproductive tract and, or by unidentified gonococcal resistance mechanisms. In the approaching era of untreatable gonorrhea, topical administration of bactericidal amounts of SLPI or the use of agents that induce higher levels of expression could be envisioned as a valid therapeutic strategy against gonococcal infections. Examination Of The Role Of Secretory Leukocyte Protease Inhibitor (SLPl)
During Gonococcal Infection
by
Anita Marinelli
Dissertation submitted to the Faculty of the Emerging Infectious Disease Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Doctor of Philosophy 2014 ANITA MARINELLI
SUMMARY PhD student in Emerging Infectious Diseases (Microbiology and Immunology). Expertise in the study of host-pathogen interaction and innate immune responses to infection in vitro and in vivo. Research experience in bacteriology, virology, immunology and cell biology. Independent and flexible worker, capable of carrying out multiple projects simultaneously. Excellent communication skills with the ability to relay complex concepts to both scientific and non-scientific audiences.
EDUCATION PhD candidate, Microbiology and Immunology expected July 2014 GPA3.97 Uniformed Services University of the Health Sciences, Bethesda MD MS, Pharmaceutical Biotechnology March 2008 Summa cum laude University of Bologna, Italy BS, Medical Biotechnology September 2005 Summa cum laude University of Bologna, Italy
RESEARCH EXPERIENCE Doctoral Research August 2008 - Present Uniformed Services University of the Health Sciences, Bethesda, MD Examination of the role of secretory leukocyte protease inhibitor (SLPI) in gonococcal infection (Advisor: Ann E. Jerse, PhD). Assessed in vitro bactericidal activity of SLPI against Neisseria gonorrhoeae and potential resistance mechanisms. Determined SLPI expression pattern during gonococcal infection of female mice and the impact of SLPI expression on gonococcal survival in SLPl-deficient mice. • Presented research at national and international meetings • Abstract highlighted for an oral presentation at the 2013 Gordon Conference on Antimicrobial Peptides • Developed in vitro assays for testing recombinant peptides against Neisseria gonorrhoeae • Conceptualized and implemented a new protocol to measure adherence of peptides to bacterial surface via FACS • Measured expression of antimicrobial peptides in a mouse model of gonococcal infection via real time PCR and ELISA • Developed a protocol to assess ascending gonococcal infection in a mouse model Additional projects: • Analysis of the impact of Lactobacillus spp. on the innate immune response to N. gonorrhoeae in vitro and in vivo in a female mouse model in terms of inflammation and cytokine production • Characterization of a Chlamydia muridarum and N. gonorrhoeae coinfection model • Investigation of the role of the human receptor CD36 in Kaposi's sarcoma-associated Herpesvirus infection and lytic replication in primary and immortalized cell lines Master Thesis Research April 2007 - March 2008 Laboratory of G-protein-mediated signaling, Consorzio Mario Negri Sud, Italy Analysis of the activity of orthosteric and allosteric inhibitors of IL-8 signaling. • Principal liaison in collaboration with a pharmaceutical company for testing novel anti-inflammatory candidates • Transfected multiple cell lines with wild-type and mutant human IL-8 receptor • Measured expression of IL-8 receptors with confocal microscopy • Optimized a radiolabel-based assay to measure signaling activity of the receptors in purified membrane fractions • Prepared and presented scientific reports to principal investigator Bachelor Thesis Research May - August 2005 Laboratory of vascular biology and pharmacology, Consorzio Mario Negri Sud, Italy • Isolated platelets from human blood • Measured expression and activity of COX1 and COX2 with molecular and biochemical methods • Prepared and presented scientific reports to principal investigator Summer Research Intern August 2004 Laboratory of tumor cell invasion, Consorzio Mario Negri Sud, Italy • Maintained human cell lines in culture • Performed in vitro assays to measure cell invasion
TECHNICAL SKILLS • Animal models: extensive experience with mouse models of infection including N. gonorrhoeae, C. muridarum and Lactobacillus spp.; proficient in tissue and lymph node harvesting, maintenance of mouse breeding colony, intraperitoneal and subcutaneous injections, peritoneal macrophage collection, immunization techniques (intranasal and subcutaneous), sample collection (serum and vaginal lavages) • Cell biology: tissue culture of primary and immortalized cell lines, transfection, membrane purification, radio-labeled GPCR assay, light and confocal microscopy, immunofluorescence, multi color flow cytometry, ELISA, Western blotting • Molecular biology: DNA/RNA extraction, cDNA synthesis, PCR and real-time PCR, DNA cloning and sequence analysis • Essential microbiology techniques: culture of Gram(-) and Gram(+) bacteria and Human Herpesvirus-8, in vitro bactericidal assays with antimicrobial peptides
GRANTS and AWARDS USU HS Student Training Grant (December 2010). Project title: "Effect of human vaginal Lactobacillus species on the innate immune responses to Neisseria gonorrhoeae" FEMS Young Scientist Meeting Grant (July 2012). Abstract title: "Expression and Role of Secretory Leukocyte Protease Inhibitor (SLPI) during Neisseria gonorrhoeae Infection of Female Mice" presented at the 18th International Pathogenic Neisseria Conference in Wurzburg, Germany
PUBLICATIONS Marinelli A. and Jerse A. E. "Role of Secretory Leukocyte Protease Inhibitor during experimental Neisseria gonorrhoeae infection" manuscript in preparation Conant K.L., Marinelli A., Kaleeba J.A. "Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi's sarcoma and P. falciparum malaria". Front. Microbiol. 2013 Sep 19;4:281.
ABSTRACTS and ORAL PRESENTATIONS 1. Marinelli A. and Jerse A. E. "Role of Secretory Leukocyte Protease Inhibitor during Neisseria gonorrhoeae infection". Gordon Research Conference on Antimicrobial Peptides. Ventura, CA. February 24 - March 1, 2013 (oral and poster presentation) 2. Marinelli A. and Jerse A. E. "Expression and Role of Secretory Leukocyte Protease Inhibitor (SLPI) during Neisseria gonorrhoeae Infection of Female Mice". 181h International Pathogenic Neisseria Conference. Wurzburg, Germany. September 9 - 14, 2012 (poster presentation) 3. Yedery R., Marinelli A., Shafer W. M., Jerse A. E. uSulforaphane induces the expression of antimicrobial peptides that kill Neisseria gonorrhoeae and suppresses inflammation induced by gonococcal lipooligosaccharide". 18th International Pathogenic Neisseria Conference. Wurzburg, Germany. September 9 - 14, 2012 (oral presentation by Yedery R.)
PROFESSIONAL DEVELOPMENT and MEMBERSHIPS ASM Science Teaching Fellow (2013 - 2014) • Selected in a cohort of 50 students and post-docs to participate in a highly focused training experience involving attendance of a webinar series and assignments, including readings and skill building activities (e.g., short questions, problems, and cases) about undergraduate teaching and curriculum design Association for Women in Science (AWIS), Secretary, Bethesda chapter executive board member (2013 - 2014) National Association of Italian Biotechnologists (ANSI), Executive board member (2013 - 2014) Docent at the Smithsonian National Museum of Natural History, Washington DC (June-December 2013) Volunteer at the USA Science and Engineering Festival, Washington DC (2012) American Society for Microbiology (ASM)
TAB 11
Degree Granting: School of Medicine Graduate Programs
LTC Mark Smith
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September 2, 2014
MEMORANDUM FOR BOARD OF REGENTS ~ .,
Through: Charles L. Rice. M.D., President ~(v...L l,. -
SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for certification to receive the Doctor of Philosophy effective upon your approval:
LTC Mark Smith
DOCTOR OF PI IILOSOPHY
Emerging Infectious Diseases Graduate Program
Attached is the candidate's certification of successful completion of the Final Examination. Also attached are the Dissertation Approval Fonn. certification of authorized use of copyrighted materials, Thesis Abstract. Thesis Title Page, and Curriculum Vitae. A~l~ti~tL / Dean. USU. School of Medicine
Attachments: As stated
=>rinted on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
FINAL EXAMINATION/PRIVATE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY rN THE EMERGING INFECTIOUS DISEASES GRADUATE PROGRAM
Name of Student: Mark Smith
Date of Examination: July 3, 2014
Time: 1O:OOam
Place: 84004
DECISION OF EXAM INATION COMM ITTEE MEMBERS:
PASS FAIL
MICROBIOLOGY AND IMMUNOLOGY
Dr. Alison D. O'Brien i DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
OF EMERGING INFECTIOUS DISEASES Committee Member
Dr. Stephen J. Davies DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Committee Member
Gregory P. Mueller, Ph.D., Assoc ate Dean (Acting II www.usuhs.mil/graded [email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 / 9474 II DSN. 295-9474 II Fax: 301 -295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
DISSERTATION APPROVAL FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE MOLECULAR AND CELL BIOLOGY GRADUATE PROGRAM
Title of Dissertation: "Development of Vaccines Against Uropathogenic Escherichia coli Toxins to Reduce Morbidity Associated with Urinary Tract Infections"
Name of Candidate: Mark Smith Doctor of Philosophy Degree July 2, 2014
DISSERTATION AND ABSTRACT APPROVED:
DATE:
MICROBIOLOGY AND IMMUNOLOGY Committ~ Chairperson I l 1.& -\._, (k _,\ '----- Dr~Alison D. O'Brien DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY ....._ D/e',, Advi.sof/ __-z, ~ r
Committee Member
Dr. Stephen J. Davies DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Committee Member
Gregory P. Mueller Ph 0., Associ ate Dean (Acting www.usuhs.mil/graded [email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 I 9474 II DSN: 295 9474 II Fax: 301-295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:
.. Development ofVaccmes Agrunst Uropathogenic £sc.:herichw coli Toxins to Reduce Morbidity Associated \\ith Urinary Tract Infections..
is appropriately acJ..nowlcdged and. beyond brief excerpts. is \i.1th !he penmss1on of the copyright O\\ner. · 2!!sJ:~-- Molecular and Cell Biology Graduate Program Uniformed Sef\ ices Unt\ ersily 18/07/2014 ABSTRACT
Title of Dissertation:
Development of Vaccines Against Uropathogcnic Escherichia coli Toxins to Reduce Morbidity
Associated with Urinary Tract Infections
Mark A Smith, Doctor of Philosophy, 2014
Thesis directed by:
Alison O'Brien, Ph.D.
Professor and Chair, Department of Microbiology and Immunology
Uniformed Services University of the Health Sciences
Urinary tract infections (UTis) are estimated to affect eighty percent of women in the United
States annually with a resulting cost of billions of dollars spent on physician visits, treatment, and lost work hours. Uropathogenic £. coli (UPEC) are the leading cause of UTis. Previous research in our
laboratory demonstrated that female C3H/HeOuJ mice that arc transurethrally infected with UPEC strain
CP9 into the urinary bladder develop a suppurative cystitis with severe submucosal edema within 24
hours of bacterial inoculation. Researchers in our laboratory also reported that CP9 strains with
inactivated Cytotoxic Necrotizing Factor I (CNFl) and/or the Hemolysin (HlyA) genes evoke less severe pathology in the urinary bladder than does the wild type strain. CNF! and HlyA arc toxins that contribute
to UPEC pathogenesis. CNFl enzymatically causes constitutive activation of small Rho family GTPases
that leads to cytoskeletal changes in host cells. HlyA forms membrane pores and lyses mammalian cells.
CNFI and HlyA contribute to the robust inflammatory response in the bladders of mice challenged for
24hrs with the UPEC strain CP9. We hypothesized that antibodies against CNF I and/or HlyA will reduce the pathology caused by CP9 infection of the bladder. Therefore, we actively immunized mice with a
HlyA toxoid in which two essential lysine residues were changed to glutamic acid. Female C3HIHe0uJ mice were vaccinated subcutaneously twice with HlyA toxoid in adjuvant and boosted once or twice more without adjuvant. We collected serum prior to each boost, and we observed increases in anti-HlyA titers over time by ELISA and elevations in neutralizing antibody levels as assessed by erythrocyte lysis neutralization after the second boost. Two weeks after the final boost, we challenged the mice intraurethrally with CP9 and sacrificed them 24 hr later. We observed a reduction in urine colonization in
HlyA-vaccinatcd mice compared to sham-vaccinated mice but the reduction was not statistically significant. There was no difference in kidney colonization between the two groups. HlyA-vaccinatcd mice exhibited significantly reduced cystitis when compared to sham-immunized mice. We also actively immunized mice with a CNF! toxoid in which an essential cysteine residue within the catalytic site was changed to serine. Mice were immunized subcutaneously once with CNFI toxoid in adjuvant and boosted three times with CNFl toxoid combined with sublethal doses of CNFI without adjuvant. We collected serum prior to each boost and observed an increase in anti-CNF I titers over time by ELISA and an enhancement of neutralizing antibody titers as assessed by inhibition of multinucleation of HEp-2 cells, a CNFJ-mediated phenotype. Two weeks after the final CNF! toxoid/ CNFI boost, we challenged the mice. We observed no differences in urine bacterial counts or in kidney counts between the CNF I - vaccinated mice and sham-vaccinated mice. There was also no reduction in cystitis in CNF I -vaccinated mice. To determine whether antibodies against CNFI could reduce cystitis, we passively administered a
CNF-neutralizing monoclonal antibody intraperitoncally to mice 24hr and 4hr prior to intraurethral challenge with CP9. After 24hr, we collected urine, sacrificed the mice and harvested the bladder and kidneys. Enumeration of bacteria in the urine and kidneys showed that the anti-CNF I antibody did not affect colonization. However, the anti-Cl\r I antibody caused a significant reduction in cystitis when compared to bladders of mice given an isotype control antibody. Taken together, our data show that
antibodies against CNFI or HlyA reduce the bladder pathology caused by UPEC. Development of Vaccines Against Uropathogenic Escherichia coli Toxins to
Reduce Morbidity Associated with Urinary Tract Infections
by
Mark A. Smith
Dissertation submitted to the Faculty of the
Molecular and Cell Biology Graduate Program
Uniformed Services University of the Health Sciences
In partial fulfillment of the requirements for the degree of
Doctor of Philosophy 2014 MARK A. SMITH, V.M.D. Diplomate ACVP Lieutenant Colonel, United States Army Veterinary Corps
Education USUHS - Ph.D. Candidate (Molecular Biology) 2009-2014 (projected) AFIP - ACVP Board Certification 2006 University of Pennsylvania - V.M.D. 1997 Temple University - B.S. Biology 1991
Assignments WRAIR - Vet. Biomedical Researcher/Pathologist 2012-present USUHS - PhD Student/Pathologist 2009-2012 USAMRllD - Biodefense Research Pathologist 2006-2009 AFIP - Pathology Resident 2003-2006 SEVD- Chief, Vicenza Branch 2000-2003 MFO, Egypt- Force Veterinarian 1999-2000 Luke AFB, AZ - Section Chief 1997-1999
Other Professional Experience ACVP Government Policy Committee 2009-present Institutional Animal Care and Use Committee, USAMRIID 2007 to 2009 Government Liaison, CDMRP and MRMC, Reston, VA 2007 Emergency Service Clinician, Phoenix, AZ 1998-1999 Epidemiology Preceptor, CDC, Atlanta, GA 1996-1997 Veterinary Extern, Philadelphia Zoo, Phila, PA, 1996 Research Assistant, University of Pennsylvania, Phi la, PA, 1995 Project - Invasiveness of mutant strains of Salmonella enteritidis
Publications 1. Vijayakumar V, Santiago A, Smith R, Smith MA, Robins-Browne RM, Nataro JP, Ruiz-Perez F. Role of Class 1 Serine Protease Autotransporter in the Pathogenesis of Citrobacter rodentium Colitis. Infect Immun. 2014 Jun; 82(6):2626-36. 2. Russo LM , Melton-Celsa AR, Smith MA, Smith MJ, O'Brien AD. Oral intoxication of mice with Shiga toxin type 2a (Stx2a) and protection by anti-Stx2a monoclonal antibody llE lO. lnfect Immun. 2014 Mar; 82(3):1213-21. 3. Flora AD, Teel LD, Smith MA, Sinclair JF, Melton-Celsa AR, O'Brien AD. Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys. PLoS One. July 2013 4. Zumbrun SD, Melton-Celsa AR, Smith MA, Gilbreath JJ, Merrell DS, O'Brien AD. Dietary choice affects Shiga toxin-producing Escherichia coli (STEC) 0157:87 colonization and disease. Proc Natl Acad Sci USA. June 2013 5. Zangari T, Melton-Celsa AR, Panda A, Boisen N, Smith MA, Tatarov I, De Tolla LJ, Nataro JP, O'Brien AD. Virulence of the Shiga toxin type 2-expressing Escherichia coli 0104:H4 German outbreak isolate in two animal models. Infect lmmun. May 2013 6. Garcia TA, Venhtra CL, Smith MA, Merrell DS, O'Brien AD. Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host r esponses in the murine bladder. Infect Immun. Jan 2013 7. Hensley LE, Smith MA, Geisbert JB, Fritz EA, Daddario-DiCaprio KM, Larsen T, Geisbert TW. Pathogenesis of Lassa fever in cynomolgus macaques. Virol J. May 2011 8. Cashman KA, Smith MA, Twenhafel NA, Larson RA, Jones KF, Allen RD 3rd, Dai D, Chinsangaram J, Bolken TC, Hruby DE, Amberg SM, Hensley LE, Guttieri MC. E valuation of Lassa antiviral compound ST-193 in a guinea pig model. Antiviral Res. Apr 2011 9. Warren TK, Warfield KL, Wells J, Enterlein S, Smith MA, Ruthel G, Yunus AS, Kinch MS, Goldblatt M, Aman MJ, Bavari S. Antiviral Activity of a Small-Molecule Inhibitor of Filovirus Infection. Antimicrobial Agents and Chemotherapy, May 2010 10. Geisbert TW, Daddario-DiCaprio KM, Hickey AC, Smith MA, Chan YP, Wang LF, Mattapallil JJ, Geisbert JB, Bossart KN, Broder CC. Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection. PLoS One. May 2010 11. Rozak DA, Gelhaus HC, Smith MA, Zadeh M, Huzclla L, Waag D, Adamovicz JJ. CpG oligodeoxyribonucleotides protect mice from Burkholderia pseudomallei but not Francisella tularensis Schu S4 aerosols. J Immune Based Thcr Vaccines. Feb 2010 12. Bradfute SB, Swanson PE, Smith MA, Watanabe E, McDunn JE, Hotchkiss RS, Bavari S. Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. J Immunol. Jan 2010 13. Geisbert TW, Daddario-Dicaprio KM, Lewis MG, Geisbert JB, Grolla A, Leung A, Paragas J, Matthias L, Smith MA, Jones SM, Hensley LE, Feldmann H, Jahrling PB. Vesicular stomatitis virus-based ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates. PLoS Pathog. Nov 2008 14. Smith MA, Schulman FY. Subcutaneous Neoplasms of the Ventral Abdomen with Features of Adrenocortical Tumors in Two Ferrets. Veterinary Pathology, 2007
Posters and Presentations I. Smith M, Kaminski RW, Clarkson K, Pierson T, Bryant N, Marll M, Pratt M, Turbyfill KR, Oaks EV Non-GLP Mouse Toxicology Studies of Slrige/la Invaplex., Vaccine Delivered via Intradermal, Subcutaneous, and Intranasal Routes. Poster, 1th annual Conference of Vaccine Research, Bethesda MD, 2014 2. Smith MA, Ventura CL, and O 'Brien AD Antibodies against Cytotoxic Necrotizing Factor 1 or Hemolysin Reduce Bladder Inflammation Caused by Uropathogenic E. coli. Poster, ASM General Meeting 2013 3. Weingarten RA, Smith MA, Ventura CL, O 'Brien AD Characterization of the Hemolysins of Uropathogenic Escherichia coli Poster, ASM General Meeting 2011
Acronyms AFB Air Force Base ACVP American College of Veterinary Pathologists ASM American Society for Microbiology AFIP Armed Forces Institute of Pathology AMEDD Army Medical Department CDMRP Congressionally Directed Medical Research Programs ILE Intermediate Level Education MM CBC Medical Management of Chemical and Biological Casualties MRMC Medical Research and Materiel Command MFO Multinational Force and Observers SEVD Southern Europe Veterinary Detachment USUHS Uniformed Services University of the Health Sciences USAMRIID United States Army Medical Research Institute oflnfcctious Disease
TAB 12
Degree Granting: School of Medicine Graduate Programs
Tonia Zangari
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September '.L 2014
ME:\10RANDUM FOR BOARD OF REGENTS
Through: Charles L. Rice. M.D .. President ~{<-< [Q,' -
SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for certification to receive the Doctor of Philosophy effective upon your approval:
Tonia Zangari
DOCTOR OF PHILOSOPHY
Emerging Infectious Diseases Graduate Program
Anached is the candidate's certification of successful completion of the Final Examination. Also anached are the Dissertation Apprornl Form. cenification of authorized use of copyrighted materials. Thesis Abstract. Thesis Title Page. and Curriculum Vitae. Cw! Arthur L. Ke lermann. MD. MPH Dean. USU. School of Medicine
Attachments: As stated
Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
FINAL EXAMlNATIONIPRTV ATE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE EMERGING INFECTIOUS DISEASES GRADUATE PROGRAM
Name of Student: Tonia Zangari
Date of Examination: August 11, 2014
Time: I O:OOam
Place: B4004
DECISION OF EXAMINATION COMMITTEE MEMBERS:
PASS FAIL
Dr. Ann Jerse DEPARTMEN E CROBIOLOGY AND IMMUNOLOGY Comwittee Chairpersop ( _L 1 " L~ 1,, "-' i- DY Alison O'Brien DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY / Dr. G · opher Broder DEPARTMENT OF MICROBIOLOGY & IMMUNOLOGY C~b:Jv- / Dr. Edward Mitre DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Committee Member
~ -1>/l /G'.-t'~f-- /y.!? Dr. Peter Feng DIVISION OF MICROBIOLOGY FOOD AND DRUG ADMINISTRATION Committee Member
Gregory P. Mueller, PhD., Associate Dean (Acting II www.usuhs.mil/graded II [email protected] To ll Free: 800-772-1747 II Commercial 301-295-3913 I 9474 I DSN. 295·9474 II Fax: 301 295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
DISSERTATION APPROVAL FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE EMERGING INFECTIOUS DISEASES GRADUATE PROGRAM
Title of Dissertation: "THE CONTRIBUTION OF SHIGA TOXIN TYPE 2 (STX2) TO THE PATHOGENESIS OF E.COLI 0 157:H7 AND E. COLl 0 104:H4 "
Name of Candidate: Tonia Zangari Doctor of Philosophy Degree August 11 , 2014
DISSERTATION AND ABSTRACT APPROVED:
DATE:
Dr. Ann Jerse DEPARTMENT d MICROBIOLOGY AND IMMUNOLOGY Co(Llm · · e ~hairperso{_n f i 1 ''/ 1-J \../ 'i~A. ~ Dr. Alison O'Brien DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Di~· '-- / / Dr. Cbr.t.st er rode DEP~MENT OF MICROBIOLOGY & JMMUNOLOGY Com · ne7;,r~er , ~ ~£1 dJ ie1 ~ . Dr. Edward Mitre DEPARTMENT OF MICROBIOLOGY & IMMUNOLOGY Committee Member ~ .])~. /'r5 /'t?-,e ~t?Al'f? Dr . Pet er Feng DIVISION OF MICROBIOLOGY FOOD AND DRUG ADMINISTRATION Commi ttee Member
Gregory P. Mueller, Ph.D., Associate Dean (Acting I www.usuhs.mil/graded II [email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 I 9474 I DSN: 295 9474 II Fax: 301-295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:
"The Contribution of Shiga Toxin Type 2 (Stx2) to the Pathogenesis of E. coli 0157 :H7 and E. coli 0104:H4" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
~T.·Z~· orua angari 0 () EID, MIC Uniformed Services University 28 June 2014 ABSTRACT
The Contribution of Shiga Toxin Type 2 (Stx2) to the Pathogenesis of E. coli Ol 57:H7 and E.coli 0104:114.
Tonia Zangari, Ph.D., 2014
Thesis directed by: Alison D. O'Brien, Ph.D., Department of Microbiology and
Immunology
Shiga toxin (Stx) -producing Escherichia coli (STEC) are pathogenic bacteria that can cause disease in humans who ingest contaminated food or water or who come in contact with infected animals. Individuals infected with the major STEC serotype associated with disease in the United States, 0 l 57:H7, can present with hemorrhagic colitis (HC) and, in some patients, the hemolytic uremic syndrome (HUS). The latter is a a serious sequela of infection that can cause kidney failure Stxs are the primary virulence determinants of STEC that are required for serious disease to develop in infected persons. There arc two major serologically-distinct groups of
Stxs, Stx l and Stx2. These toxins have the same mode of action and receptor, but antiserum to one does not neutral i7c the other. There are a number of subtypes, or variants, within each of these toxin groups that differ in some facet of biological or immunological activity from the prototype toxin in each category (called Stx I a and Stx2a). These phenotypes occur despite the fact that the variants are often highly homologous to the prototype toxin. Indeed, Stx2a and
Stx2c are 97% homologous at the amino acid level. Epidemiological studies suggest that stx2t E. coli 0157 :H7 and stx2+ stx2c- E. coli 0157: H7 are associated with more severe disease in humans compared to E. coli 0157:H7 isolates that contain other stx allele combinations. In support of this observation, previous work in our laboratory demonstrated that E325 l l, an E. coli O l 57:H· that produces both Stx2a and Stx2c, is more virulent in the streptomycin-treated mouse model than other 0157 that express Stxla and Stx2a. Additionally, a follow-up study demonstrated that, when expressed by E. coli K-12 transformed with a plasmid encoding either stx2a or st<2c cloned from E3251 I, the st.x 2 c~ strain was virulent in streptomycin-treated mice. A 2006 spinach associatcd outbreak of0157:H7 resulted in higher hospitalization and HUS rates than previous
0 I 57:H7 outbreaks, and the isolate responsible for that outbreak, K3995, contains both stx2 and stxic- In our first investigation (described in chapter 2), we tested the hypothesis that the virulence ofK3995 is due to the combination of those stx2 alleles. For that purpose, we compared the virulence of K3995 and an isogenic stx2a mutant to other 0157:ll7 outbreak strains
(86-24 stx2/ or 2812 stx13 stx2a+) in mouse and/or rabbit models. In our second study (detailed in chapter 3), we focused on the role of Stx2a in the pathogenesis of a recently-emerged STEC strain, £. coli of 0104: H4 serotype that produced Stx2a. In May 2011, a large food-borne outbreak ultimately linked to sprouts occurred in Germany. That outbreak was attributed to an unusual strain of E. coli That 0 I 04:H4 E. coli produces Stx2a but otherwise has the genetic profile of an enteroaggregative E.coli (EAEC) strain. We developed a mouse infection model to srudy both the pathogenesis and possible treatments for this unique strain. The virulence of the isolate for Dutch belted rabbits was also examined.
We found that the virulence of both the 0157:H7 spinach outbreak strain, K3995, and the
O 104:H4 sprout-associated strain, C227-l I, were associated with the presence and expression of stx23 . We further correlated the virulence of K3995 with an increased level of Stx2 production and stxi-bearing phage induction when compared to another 0157:H7 outbreak strain, 86-24. We also developed an ampicillin-treated mouse model to study the pathogenesis of C227-l l, and propose that this animal system represents a new tool to study the contribution of various bacterial factors to EAEC infection and disease. THE CONTRIBUTION OF SHIGA TOXIN TYPE 2 (STX2) TO THE PATHOGENESIS OF
ESCHERICHIA COL/0157:H7 ANDE. COL10104:H4
by
Tonia Zangari
Dissertation submitted to the Faculty of the Emerging Infectious Disease Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Doctor of Philosophy 2014 Tonia Zangari
School Address Dept. of Microbiology and Immunology Uniformed Services University 4301 Jones Bridge Rd Bethesda, MO 20814 301-295-3421
EDUCATION Uniformed Services University of the Health Sciences (2014) Ph .D., Emerging Infectious Disea ses
Bloomsburg University of Pennsylvania (2006) B. S., Biology
RESEARCH EXPERIENCE Uniformed Services University of the Health Sciences (2007-2014) Graduate Research, Emerging Infectious Diseases. &!vlli2!:: Alison D. O'Brien, Ph .D. Thesis Committee: Ann E. Jerse, Ph.D (chair); Alison D. O'Brien, Ph.D.; Christopher C. Broder, Ph. D; Edward M itre, M.D.; and Peter Feng, Ph.D. " The Contribution of Shiga Toxin 2 to the Pathogenesis of Enterohemorrhagic Escherichia coli 0157:H7 and Enteroaggregative E.coli 0104:H4".
Bloomsburg University of Pennsylvania (2003-2005) Undergraduate Research, Microbiology and Ecology. Advisors: Judith Kipe-Nolt, Ph.D. and Barry Nolt, Ph.D. Honors Thesis: "An Evaluation of Coliform and Odor Reductions in Swine Manure Achieved Through Anaerobic Digestion and Composting".
SPECIALIZED SKILLS Research experience in microbi ology. Molecular Techniques: Nucleic acid extraction, isolation, digestion, and ligation; gene cloning; site directed mutagenesis by PCR (splicing by overlap extension); Western, Southern, dot, and co lony blots; DNA and protein gel electrophoresis, PCR, sequencing. Mouse Work: Handling mice, necropsy, intraperitoneal injection, blood collection by tail vein, feeding by pipette. M icrobiology: bacterial site-directed mutagenesis by Lambda-Red recombination, bacteriophage isolation, diluting and plating to determine CFU, bacterial transformation. Experience working with CDC select agents. Knowledge of biocontainment procedures, laboratory safety, biosecurity, and decontamination. Computing: MS Office Suite, Photoshop, Illustrator, GraphPad Prism. Proficiency and clarity in written and oral communication skills for presentation of scientific results and concepts. Ability to work independently and as part of a team.
HONORS AND ACTIVITES Uniformed Services University of the Health Sciences Member, Student ASM, USUHS Chapter EID Representative, Graduate Student Council Student Representative, USUHS Names and Honors Committee 201 4 Graduate Student Colloquium Oral Presentation Finalist
Bloomsburg University of Pennsylvania Bloomsburg University Honors Program (2002-2006) Board of Governors Scholarship for Leadership (full tuition) (2002-2006) Dean's list Awardee Second place, Ecology Platform Presentation, CPUB (2005) Scholar-Athlete Awardee (2003-2007)
MEETING ABSTRACTS
2014 Poster Presentation: "Enhanced virulence of an Escherichia coli 0157:H7 outbreak strain in t wo animal models is associated with higher levels of Stx2 production". American Society for Microbiology General Meeting, Boston, MA.
2014 Oral Presentation: "Enhanced virulence of an Escherichia coli 0157:H7 outbreak strain in two animal models is associated with higher levels of Stx2 production". USU School of Medicine Graduate Programs Research Colloquium, Bethesda, MD.
2012 Poster Presentation: "Enhanced virulence of the Escherichia coli 0157:H7 spinach-associated outbreak strain in two animal models". American Society for Microbiology General Meeting, San Francisco, CA.
2012 Poster Presentation: "The German 0104:H4 Shiga toxin type 2 (Stx2)-positive Escherichia coli (STEC) Outbreak Isolate, C227-ll, is Virulent in Mice and Rabbits". USU School of Medicine Graduate Programs Research Colloquium, Bethesda, MD.
2011 Poster Presentation: "Enhanced Virulence of the Escherichia coli 0157:H7 Spinach-Associated Outbreak Strain in Two Animal Models". USU School of Medicine Graduate Programs Research Colloquium, Bethesda, MD.
2005 Oral Presentation: "An Evaluation of Coliform and Odor Reductions in Swine Manure Achieved Through Anaerobic Digestion and Composting". Commonwealth of Pennsylvania University Biologists (CPUS) Annual Meeting, Millersville University & College of Science and Technology, Millersville, PA.
International M eetings 2012 Poster Presentation: "Enhanced virulence of the Escherichia coli 0157:H7 spinach-associated outbreak strain in two animal models". 8th International Symposium on Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections, Amsterdam, The Netherlands.
PUBLICATIONS
Zangari, T., Melton-Celsa, A.R., Panda, A., Smith, M .A., Tatarov, I., DeTolla, L.J., and O'Brien, A.O. 2014. Enhanced virulence of the Escherichia co li 0157:H7 spinach-associated outbreak strain in two animal models is associated with higher levels of Stx2 production after induction with ciprofloxacin. (submitted, Infection and Immunity).
Boisen N., Hansen A.M., Melton-Celsa A.R., Zangari T., Mortensen N.P., Kaper J.B., O'Brien A.O., and Nataro J.P. 2014. The Presence of the pAA Plasmid in the German 0104:H4 Shiga toxin (Stx) type 2a- producing Enteroaggregative Escherichia coli Strain Promotes the Translocation of Stx2a across an Epithelial Cell Monolayer. (accepted, The Journal of Infectious Diseases).
Zangari T., Melton-Celsa A.R., Panda A., Boisen N., Smith M.A., Tatarov I., De Tolla L.J., Nataro J.P., O'Brien A.O. 2013. Virulence of the Shiga toxin type 2-expressing Escherichia coli 0104:H4 German outbreak isolate in two animal models. Infect lmmun. 81(5):1562-74. doi: 10.1128/IAl.01310-12.
Mohawk K.L., Melton-Celsa A.R., Zangari T., Carroll E.E., O'Brien A.O. 2010. Pathogenesis of Escherichia coli 0157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora. Microb Pathog. 48(3-4):131-42. doi: 10.1016/j.micpath.2010.01.003.
TAB 13
Degree Granting: School of Medicine Graduate Programs
David Chang
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September 2, 2014
MEMORANDUM FOR BOARD OF REGENTS ~- Through: Charles L. Rice, M.D., President ft.w_,l CJ ..._
SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for certification to receive the Doctor of Philosophy effective upon your approval:
David Chang
DOCTOR OF PHILOSOPHY
Molecular and Cell Biology Graduate Program
Attached is the candidate's certification of successful completion of the Final Examination. Also attached are the Dissertation Approval Form, certification of authorized use of copyrighted materials, Thesis Abstract, Thesis Title Page, and Curriculum Vitae. U£~~1f'( Arthur L. Kellermann, MD, MPH Dean, USU, School of Medicine
Attachments: As stated
Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICNE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MO 20814
FINAL EXAM INATION/PRIVATE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE MOLECULAR AND CELL BIOLOGY GRADUATE PROGRAM
Name of Student: David Chang
Date of Examination: July 18, 2014
Time: I :00 pm
Place: A2015
DECISION OF EXAMINATION COMMITTEE MEMBERS:
PASS FAIL
I ii NT OF MICROBIOLOGY AND IMMUNOLOGY
Dr. erald V. Quinnan PREVENTIVE MEDICINE AND BIOMETRICS Dissertation Advisor . /£#~~ Dr. Chou-Zen Giarn DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Committee Member / Dr. Sodsai Tovanabutra DEPARTMENT OF MOLECULAR VIROLOGY AND PATHOGENESIS US MILITARY HIV RESEARCH PROGRAM Committee Member
Gregory P. Mueller, Ph.D., Associate Dean www.usuhs.m1l/ graded [email protected] Toll Free: 800-772-1747 Commercial: 301-295-3913 I 9474 DSN: 295-9474 Fax: 301-295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDIONE GRADUATE PROGRAMS Graduate Education Office {A 1045) 4301 Jones Bridge Road, Bethesda, MD 20814
APPROVAL OF THE DOCTORAL DISSERTATION IN THE MOLECULAR AND CELL BIOLOGY GRADUATE PROGRAM
Title of Dissertation: "Advancing HlV-1 Vaccine Design: Understanding the Connection Between HIV-I Viral Envelope and the Induced Neutralizing Antibody Response, and the Development of an Alphavirus-based HIV-I Vaccine Vector"
Name of Candidate: David Chang Doctor of Philosophy Degree July 18, 2014
DISSERTATION AND ABSTRACT APPROVED:
DATE:
a allil OF MICROBIOLOGY AND IMMUNOLOGY
Dr. Gerald V. Quinnan PREVENTIVE MEDICINE AND BlOMETRJCS Dissertation Advisor ~c;J Dr. Chou-Zen Giam DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY Committee Member _s-. / .. .._ Dr. Sodsai Tovanabutra DEPARTMENT OF MOLECULAR VIROLOGY AND PATHOGENESIS US MILITARY HIV RESEARCH PROGRAM Committee Member
Gregory P. Mueller, Ph.D. • Associate Dean www.usuhs.mil/graded [email protected] Toll Free: 800· 772·1747 Commercial: 301·295·3913 / 9474 OSN: 295-9474 Fax: 301-295-6772 COPYRIGHT STATEMENT
The author hereby certifies that the use of any copyrighted material in the dissertation manuscript entitled:
"Advancing HIV-1 Vaccine Design: Understanding the Connection Between HIV-1
Viral Envelope and the Induced Neutralizing Antibody Response, and the
Development of an Alpha, 1irus-based HIV-1 Vaccine Vector"
is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
[Signature]
David Cha-Han Chang
July 30, 2014
VI ABSTRACT
Advancing HIV-1 Vaccine Design: Understanding the Connection Between IDV-1
Viral Envelope and the Induced Neutralizing Antibody Response, and the
Development of an Alphavirus-based HJV-1 Vaccine Vector
David Cha-Han Chang, Ph.D., 2014
Thesis directed by: Gerald V. Quinnan, Jr., M.D. RADM (Ret), USPHS, Professor and
Chair of Preventive Medicine and Biometrics, Department of Preventive Medicine and
Biometrics, Uniformed Services University
Induction of potent, broadly cross-reactive neutralizing antibodies (bcnAbs) remains a primary goal in HIV-1 vaccine development. Human clinical trials of HIV-1 vaccines have been largely unsuccessful until recently, when the RV144 Thai vaccine study demonstrated modest efficacy in preventing the acquisition of virus. These trials have highlighted the complexities of designing and delivering an immunogen capable of eliciting a humoral and/or cell mediated immune response. We investigated both of these aspects of vaccine design, beginning with a focus on screening for HIV-I infected individuals who develop bcnAbs, and looking for connections between the envelope glycoprotein from early infection and the induced neutralizing antibody response. We also developed a potential replication competent HIV- I vaccine vector based on the
Vll alphavirus, Fort Morgan Virus, and tested its safety and immunogenicity in a small
animal pilot study.
We screened sera from 157 individuals of the U.S. Military HIV Natural History
Study Cohort for neutralization against a diverse panel of HIV-1 virus envelope clones.
We found that bcnAbs were likely to be found across all HIV-1 disease progression
groups, which included elite and viremic controllers, long tenn non-progressors, and
rapid and typical progressors. Elite controllers, however, were found to be poor
neutralizers. We compared six each of the best and worst neutralizers for differences in
HIV-1 envelope neutralization sensitivity and sequence, and for differences in serum
neutralization specificity. We found evidence of increased positive selection in envelope
clones, and serum neutralization targeting specific epitopes in top neutralizers. Overall,
envelope clones from top neutralizers were more sensitive to neutralization by
monoclonal antibodies targeting CD4-induced epitopes. Additionally, we identified a
patient (one of the top neutralizers) who possessed early envelope clones that were
resistant to neutralization by monoclonal antibodies targeting the CD4 binding site and a
glycan dependent epitope in V3, and also possessed serum antibodies directed towards
the same two epitopes. We hypothesize that induction of bcnAbs may be related to the
persistence of certain neutralization resistant viruses early in infection.
Alphaviruses have been shown to target dendritic cells and traffic to draining
lymph nodes, where they produce high levels of antigen amidst resident antigen
presenting cells. Fort Morgan Virus, carried by bedbugs that infest the nests of sparrows
and swallows, is not known to be pathogenic in humans. We developed Fort Morgan
Virus (FMV) as a replication competent vaccine vector that stably expresses HIV-1
Vlll envelope glycoproteins in vitro. We confirmed stable expression of in each successive round of plaque purification, a significant accomplishment in light of the combined size of the FMV RNA genome with HIV- I transgene. Our novel FMV vector is one of only
two non-attenuated, replication competent vectors that have been developed for HIV-1.
In a small in vivo pi lot study of safety and immunogenicity in rabbits, wc found elevated,
statistically significant serum anti-gpl40 binding levels (measured by ELISA) in two
immunized animals. Immunizations were well tolerated and no obvious abnormalities
were observed in any of the animals. We completed a proof of concept FMV vaccine
vector that merits further characterization and additional animal testing.
lX Advancing HIV-I Vaccine Design: Understanding the Connection Between HIV-I Viral
Envelope and the Induced Neutralizing Antibody Response, and the Development of an
Alphavirus-based HIV-I Vaccine Vector
by
David Cha-Han Chang
Dissertation submitted to the Faculty of the Molecular and Cell Biology Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Doctor of Philosophy 2014 DAVID CHA-HAN CHANG Curriculum Vitae
EDUCATION
2007 - 2014 Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD Ph.D., Molecular and Cell Biology Graduate Program • Dissertation: "Advancing HIV-1 Vaccine Design: Understanding the Connection Between HIV-1 Viral Envelope and the Induced Neutralizing Antibody Response, and the Development of an Alphavirus-based HIV-1 Vaccine Vector" • Thesis Advisor: Dr. Gerald V. Quinnan, Jr., M.D., RADM (Ret) USPHS
2005 Un iversity of California at Berkeley BA Double Major: Molecular and Cell Biology -Immunology Emphasis, and Integrative Biology - Human Body & Health Sciences Path
RESEARCH LABORATORY EXPERIENCE
2005 - 2007 Hawaii Biotech, Aiea, Ill Research Associate, Immunology Group - Vaccine Development • Develop and perform GLP immunoassays for West Nile & Dengue Fever Viruses • Analyze immunogenicity, specificity, and long-term protection of vaccine antigens and adjuvants • Perform immunizations, bleeds, and ascites production in small animals
PUBLICATIONS
Cha ng DC, Zhang PF, Okulicz JF, Agan BK. Quinnan GV Jr. 2014. Assessment of broadly cross-reactive neutralization among different IIIV-1 disease progression groups in the US Military HIV Natural History Study. In preparation.
Cha ng DC, Zhang PF, Okulicz JF, Agan BK, Quinnan GV Jr. 2014. Comparison of HIV-1 envelope glycoprotein phenotypes and induced neutralization specificities in patients with and without broadly cross-reactive neutralization. In preparation.
Cha ng DC, Zhang PF, Liao X, Zhang Z, Yan L, Quinnan GV Jr. 2014. Development of an alphavirus-based replication competent potential HIV-1 vaccine vector. In preparation.
ABSTRACTS
Chang DC, Zhang P, and Quinnan GV. HIV-1 Envelope Glycoproteins and Broadly Cross-Reactive Neutralizing Antibody Responses in the US Military DoD HIV Natural History Study. Abstract accepted: Research Days, Uniformed Services University; 2014 May 14-15; Bethesda, MD.
Cha ng DC, Zhang P, and Quinnan GV. Neutralization Profiles of Disease Progression Groups in the US Military DoD HIV Natural History Study. Abstract accepted: HIV Vaccines, Keystone Symposia; 2013 Feb 10-15; Keystone, CO.
Chang DC, Zhang P, and Quinnan GV. Neutralization Profiles of Disease Progression Groups in the US Military DoD HIV Natural History Study. Abstract accepted: Research Days, Uniformed Services University; 2012 May 14-15; Bethesda, MD.
1 SCIENTIFIC PRESENTATIONS
Chang DC. "HIV-1 Envelope Clones from the DoD HIV Natural History Study." Molecular and Cell Biology Student Seminar Series, USU HS; 2014 Jan 9; Bethesda, MD.
Chang DC. "Neutralization in the DoD HIV Natural History Study and an alphavirus-HIV Chimeric Virus." Molecular and Cell Biology Student Seminar Series, USU HS; 2013 Jan 3; Bethesda, MD.
Chang DC. "Engineering Fort Morgan Virus to be a Vaccine Vector." Molecular and Cell Biology Student Seminar Series, USUHS; 2012 Jan 19; Bethesda, MD.
Chang DC "Dirty jobs: Finding broadly cross reactive neutralizing antibodies in HIV patients." Molecular and Cell Biology Student Seminar Series, USUHS; 2011 Feb 2; Bethesda, MD.
SPECIALIZED SKILLS & TECHNIQUES
Tissue culture Cell line maintenance, working stock production, hybridoma fusion and subcloning for production of monoclonal antibodies, mycoplasma detection assay
Virus Viral RNA isolation, virus production, pseudovirus production, alphavirus manipulation, RNA transcription, electroporation, transfection, titration, growth curve, and analysis
Serology ELISA. PRNT, lmmunofocus Forming Assay, Virus Neutralization Assay, Complement Fixation Assay, flow cytometry, protein assay
Molecular biology Mutagenesis, cloning. PCR, RT-PCR, Single Genome Amplification, protein/nucleic acid analysis, sequencing
Animal manipulation/Vaccine preparation
Animal immunization, bleed, splenectomy, dissection, ascites fluid production, adjuvant formulation, nanoparticle adsorption
Technical Liquid handling robotics programming and operation, trained to work in BSL2 and BSL3, GLP techniques SOPs and protocols, lab supply and safety management, Graph pad PRISM, Microsoft Excel, Visual Basic
Language skills English (native), Mandarin and Cantonese Chinese (fluent conversational. working technical)
MENTORSHIP & SERVICE
2011- 2012 President, Graduate Student Council Uniformed Services University of the Health Sciences, Bethesda, MD
2010 - 2011 Molecular and Cell Biology Student Representative, Graduate Student Council Uniformed Services University of the Health Sciences, Bethesda, MD
Summer2012 Summer Research Intern Mentor for Lynn Tran (University of Maryland, College Park)
Summer 2011 Summer Research Intern Mentor for Alex Garzon (Princeton University) 2
TAB 14
Degree Granting: School of Medicine Graduate Programs
Bandana-Ajay Vishwakarma
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814--4799
September 8. 2014
MEMORANDUM FOR BOARD OF REGENTS ~
Through: Charles L. Rice, M.D., President ~l i. t' ~
SUBJECT: Certification of Graduate Student
The graduate studenl listed below is presented for certification to receive the Doctor of Philosophy effective upon your approval:
Bandana-Ajay Vishwakarma
DOCTOR OF PHILOSOPHY
Molecular and Cell Biology Graduate Program
Attached is d1e candidate· s certification of successful completion of the Final Examination. Also attached are the Dissertation Approval Form. certification of authorized use of copyrighted materials, Thesis Abstract, TI1esis Title Page, and Curriculum Vitae.
~ellermann, MD, ~'11e:\/ tt{ Dean. USU. School of Medicine
Attachments: As stated
Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
FINAL EXAMINATION/PRIVATE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE MOLECULAR AND CELL BIOLOGY GRADUATE PROGRAM
Name of Student: Bandana Ajay Vishwakanna
Date of Examination: September 5, 2014
Time: I :OOpm
Place: A2052
DECISION OF EXAMINATION COMMITTEE MEMBERS:
PASS FAIL ~ Dr. Chou-Zen Giam Department of Microbiology & Immunology Committee Chairperson ~ x =Dr. Yang Du~ Department of Pediatrics Dissertation Advisor ~~. &.0 Molecular and Cell Biology Program Committ ember .~----
. Andrew Snow Dep ology Co
Gregory P. Mueller, Ph.D., Interim Associate Dean II www.usuhs.mil/graded II [email protected] Toll Free: 800 772-1747 II Commercial: 301-295-3913 I 9474 II DSN : 295-9474 II Fax: 301-295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
DISSERTATION APPROVAL FOR THE DOCTORAL DISSERT AT!ON IN THE MOLECULAR AND CELL BIOLOGY GRADUATE PROGRAM
Title of Dissertation: "Role of Sethpl in Myeloid Leukemia Development..
Name of Candidate: Bandana Ajay Vishwakanna Doctor of Philosophy Degree September 5, 2014
DISSERTATION AND ABSTRACT APPROVED:
DATE:
Dr. Chou-Zen Giam Department of Microbiology & Immunology Committee Chairperson ~Les=-=> ~/r/t'f Dr. Yang Du Department of Pediatrics Dissertation Advisor ~ D~ '1!11l'f Molecular and Cell Biology Program Committee mber
9"-- S- /:-J
Gregory P. Mueller, Ph.D., lntenm Associate Dean I www.usuhs.mil/graded I [email protected] Toll Free: 800 772-1747 II Commercial: 301295-3913/9474 I DSN: 295 9474 II Fax: 301-295-6772 COPYRIGHT STATEMENT
The author hereby ccnifies that the use of any copyrighted material in the thesis manuscript entitled:
"Role of Setbpl in Myeloid Leukemia Development" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
Bandana Ajay Vishwakanna MCB Program, Department of Pediatrics Unifonned Services University ABSTRACT
Title of Dissertation: Role of Setbpl in myeloid leukemia development.
SETBP I, an AT-hook transcription factor, was first identified through its interaction with SET.
Since then it has been implicated in development of myeloid leukemias either through overexpression or misscnsc mutation. We have found previously that ovcrcxpression of Setbpl can immortalize mouse myeloid progenitors in culture through activation of Homeobox genes,
Hoxa9 and HoxaJO both in vitro and in vivo. However, it is not known whether activation of
Setbpl alone is sufficient to induce myeloid leukemia development. Herc we show that Setbpl overexpression in murinc bone marrow progenitors through retroviral transduction is capable of
inducing myeloid leukemia development in irradiated recipient mice. In pre-leukemia stage, overexpression of Setbpl enhances the self-renewal of hematopoietic stem cells (HSCs) and expands granulocyte macrophage progenitors (GMPs). Interestingly, Setbpl activation also causes transcriptional repression of tumor suppressor gene Runxl and this effect is crucial for
Setbp /-induced transformation. Runxl repression is induced by Setbp I-mediated recruitment of
Hdacl to Runxl promoters and can be relieved by treatment with histone deacetylase (HDAC)
inhibitors entinostat and vorinostat. Moreover, treatment with these inhibitors caused efficient differentiation of Setbpl-induced myeloid leukemia cells and immortalized myeloid progenitors
in culture and significantly extended the survival of mice with Se/bpi-induced myeloid neoplasm, suggesting that HDAC inhibition could be an effective strategy for treating myeloid malignancies with SETBPJ activation. Previous observations demonstrated that overexpression of Setbp 1 in mouse bone marrow cells is capable of inducing myeloid leukemia development in mice. However, only 50% of the mice receiving Setbpl-transduced cells developed leukemia in 10 months, suggesting that additional cooperating mutations may be required for Setbpl-induced leukemia development. To identify such mutations, we cloned retroviral insertions from a total of 16 Setbpl-induced leukemias.
Interestingly, two such leukemias contained independent viral integrations at Mllt3 that activated its expression, strongly suggesting that Mllt3 may cooperate with Setbpl to induce leukemia development. To test this hypothesis, we co-transduced BM progenitors with retroviruses expressing Setbpl and Mllt3, and compared their leukemia induction potential to cells singly infected with either virus by transplantation into irradiated recipient mice. When aged for 6 months, only 2 out of 8 mice receiving cells singly transduced with Setbpl virus developed leukemia and none of the mice transplanted with Mllt3-transduced cells fell ill. In contrast, 100% of the mice transplanted with co-transduced cells developed myeloid leukemia within 92 days, confirming cooperation between Mllt3 and Setbpl in inducing myeloid leukemia development.
Moreover, we also found that co-transduction induced leukemia cells expressed significantly higher levels of Meis 1 compared to leukemia cells induced by Setbpl alone. Given that Setbpl activates Hoxa9, which is known to cooperate with Meisl in leukemic transfom1ation, this finding further suggests that Meis] activation by Mllt3 may be responsible for the cooperation between Setbpl and Mllt3.
Taken together our studies indicate that Setbpl is a novel oncogene capable of inducing myeloid leukemia development. Role of Setbpl in Myeloid Leukemia Development
by
Bandana Ajay Vishwakanna, M.Sc., M.Tcch
Dissertation submitted to the Faculty of the Molecular and Cell Biology (MCB) Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Doctor of Philosophy 2014 CURRICULUM VITAE
BANDANA AJAY VISHWAKARMA (PhD. candidate)
Molecular and Cell Biology Program Department of Pediatrics Uniformed Services University of Health Sciences 4301 Jones Bridge Road Bethesda, MD 20814 €
EDUCATION
Aug, 2009 Final Year Ph.D., Molecular and Cell Biology, CGPA - 3.55 / 4.00 -Present Thesis Project: Role of Setbp1 in Myeloid Leukemia Development Advisor: Dr. Yang Du Uniformed Services University of Health Sciences, Bethesda, MD, USA
1994-1995 M.Tech., Agricultural Engineering Specialization: Agricultural Systems and Management Indian Institute of Technology, Kharagpur, West Bengal, India
1991-1993 M.Sc., Zoology Specialization: Cytology and Molecular Genetics The University of Burdwan, West Bengal, India
1988-1991 B.Sc., Zoology Minor: Botany and Chemistry The University of Burdwan, West Bengal, India
RESEARCH EXPERIENCE
THEISIS PROJECT
• Determined the leukemogenic potential of Set binding protein 1 (Setbp1) and identified the cooperating mutations through oncogenic retrovirus induced insertional mutagenesis.
• Determined the cell types to which Setbp1 can promote self-renewal.
• Studied the effect of HDAC inhibitors - Entinostat and Vorinostat, on Setbp1-induced leukemia.
Skills and Techniques
• Cell Culture, Transfection, Production of virus and assessment of viral titer, Transduction (retronectin spinoculation ), • Cloning, Infusion cloning, Sequencing, Primer design for Infusion cloning and PCR, Western blotting, Southern blotting, Real time PCR, , FACS, Genomic DNA extraction, Cytospin, Histology (H&E staining), Chromatin lmmunoprecipitation, Co-immunoprecipitation. • shRNA knockdown (spinoculation), colony assay • Handling of mice, Retro-orbital Bleeding, Intra Peritoneal Injection, Bone Marrow Harvest PROFESSIONAL EXPERIENCE
June 2000- Lecturer, Department of Zoology, G.M. Momin Women's College, University of June 2007 Mumbai, India
Oct. 1996- Product Officer, Product Management Team, Kami Pharma Private Limited, Oct. 1997 Mumbai, India
AWARDS AND HONOURS
2013 Winner, Best Oral Presentation, Graduate Student Colloquium, Research Week, Uniformed Services University of the Health Sciences Bethesda, MD
2006 Recognized as the teacher of the University of Mumbai for the M.Sc. degree in Zoology by Papers with effect from 26th May, 2006.
2006 Appointed as Honorary Extension Work Field Coordinator for the academic year 2005-2006 and 2006-2007 by the Department of Adult and Continuing Education and Extension of University of Mumbai, India.
2003 Lectureship in Life Sciences, Awarded by the Council of Scientific and Industrial Research, India
1994 Indian Institute of Technology Assistantship Award for pursuing M.Tech in The Indian Institute of Technology, Kharagpur, West Bengal, India
1993 Ranked Second According to Merit in the M.Sc. Final Examination, University of Burdwan, West Bengal, India
TEACHING
2000-2007 Zoology, Delivered lectures and conducted practical for Bachelor of Science students in Molecular Biology, Genetics, Molecular Evolution, Toxicology, and Biotechnology
PUBLICATIONS
I . Bandana A. Vishwakarma, Kristbjorn 0 . Gudmundsson, Hideki Makishima , Naoko Honsono , Nhu Nguyen,Vijay Negi, Kevin Oakley, Jaroslaw P. Maciejewski, and Yang Du. Setbp1 induces leukemia development through repression of Runx1 .(2014) Submitted Nature Medicine (Under Review)
2. Makishima H, Yoshida K, Nguyen N, Przychodzen B, Sanada M, Okuno Y, Ng KP, Gudmundsson KO , Vishwakarma BA, Jerez A, Gomez-Segui I, Takahashi M, Shiraishi Y, Nagata Y, Guinta K, Mori H, Sekeres MA, Chiba K, Tanaka H, Muramatsu H, Sakaguchi H, Paquette RL, McDevitt MA, Kojima S, Saunthararajah Y, Miyano S, Shih LY, Du Y, Ogawa S, Maciejewski JP. Somatic SETBP1 mutations in myeloid malignancies. (2013) Nat Genet. Aug;45(8):942-6.
3. Oakley K, Han Y, Vishwakarma BA, Chu S, Bhatia R, Gudmundsson K, Keller J, Chen X, Vasko, Jenkins NA, Copeland NG, Du Y. Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. (2012) Blood 119(25):6099-108.
TAB 15
Degree Granting: School of Medicine Graduate Programs
Trevor Logan
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September 2. 2014
MEMORANDUM FOR BOARD OF REGENTS ~'
Through: Charles L. Rice, M.D., President ~l L. L:::
SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for ce11i fication to receive the Doctor of Philosophy effective upon your approval:
Trevor Logan
DOCTOR OF PHILOSOPHY
Neuroscience Graduate Program
Attached is the candidate's ce11ification of successfi.11 completion of the Final Examination. Also attached are the Dissertation Approval Form. certificatjon of authorized use of copyrighted materials. Thesis Abstract. Thesis Title Page. and Cu1Ticulum Vitae.
Attachments: As stated
Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
FINAL EXAMlNA TION/PRIV ATE DEFENSE FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN THE NEUROSC IENCE GRADUATE PROGRAM
Name of Student: Trevor Logan
Date of Examination: June 25, 2014
Time: 1:OOpm
Place: C2015
DECISION OF EXAMINATION COMMITTEE MEMBERS:
PASS FAIL J Dr. Zygmunt Galdzicki DEPA~TMENT OF ANATOMY, PHYSIOLOGY, AND GENETICS Com1 ttee Chairper~on
Dr. Kimoerly Byrnes DEPARTMENT OF ANATOMY, PHYS IOLOGY, AND GENETICS Committee Member ~ --- t/ Dr.Mart~y DEPARTMENT OF ANATOMY, PHYSIOLOGY, AND GENETICS Commilti~mber j! J
Dr.Gabrielatt- · DEPARTMENT OF PATHOLOGY Committee Member
Eleanor S. Metcalf, Ph .D., Asso ciate Dean II www.usuhs.mil/graded II [email protected] Toll Free: 800-772-1747 II Commercial: 301·295-3913 I 9474 I DSN . 295-9474 II Fax : 301-295-6772 UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
DISSERTATION APPROVAL FOR THE DOCTORAL DISSERTATION JN TIIE NEUROSCIENCE GRADUATE PROGRAM
Title of Dissertation: "Changes in Adult Neurogenesis After Traumatic Brain Injury- The role of TGF-~ Cytokines and the transcription factor Runx l"
Name of Candidate: Trevor Logan Doctor of Philosophy Degree June 25, 2014
DISSERTATION AND ABSTRACT APPROVED:
DATE: L.12}\ (IL(
D . Aviva Symes / DEPARTMENT 6f°PHARMACOLOGY Dissertati_o~or ~es 't/9/'f DEPARTMENT OF ANATOMY, PHYS IOLOGY, AND GENETICS Committee Member
D; ~:in~ -...__ -ij"lf l'f' DEPARTMENT OF ANATOMY, PHYSIOLOGY, AND GENETICS
:r/ q I IL{
Committee Member
Eleanor s. Metcalf, Ph.D., Associate Dean II www.usuhs.m11/graded II [email protected] Toll Free: 800-772-1747 II Commercial: 301-295-3913 I 9474 II DSN: 295-9474 II Fax· 301-295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:
Changes in adult neurogenesis after traumatic brain injury - the role of TGF-P cytokines and the
transcription factor Runx 1.
is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
~·--~ Trevor ogan Neuroscience Program, Pharmacology Department Uniformed Services University 8/4/14 ABSTRACT
Changes in adult neurogenesis after traumatic brain injury - the role ofTGF-~ cytokines
and the transcription factor Runxl:
Trevor T. Logan, Doctor of Philosophy, 2014
Thesis directed by: Aviva J. Symes, Associate Professor of Pharmacology
Adult traumatic brain injury (TBJ) is a common, acquired injury that often results permanent loss of neurological function. There are currently no standard treatments aimed preventing neuronal degeneration during the secondary injury phase or to facilitate of the central nervous system (CNS). Numerous studies indicate that traumatic brain increases neurogenesis in the forebrain subventricular zone (SVZ) and the hippocampal gyrus (OG). It is possible that these endogenous stem cell populations could be manipulated provide replacement neurons to facilitate CNS repair and recovery after injury. growth factor-P (TGF-~) superfamily cytokines are important regulators of adult but their involvement in regulation of neurogenesis after adult brain injury is unclear. We utilized a craniotomy and controlled cortical impact (CCI) model of TBI in the mouse to investigate the hypothesis that TBI would induce changes in the TGF-~ superfamily pathways within the adult neurogenic regions. Through analysis of qPCR array data from RNA isolated from the SVZ and DG of adult mouse at different time points after identified major changes in expression of genes involved in the TGF-p, bone morphogenetic
Vl (BMP), and activin signaling pathways. which could bear relevance to the endogenous stem and progenitor cell (NSPC) response to injury.
TBI induced expression of the transcription factor Runxl in microglia and a subpopulation ofNSPCs of the SVZ and DG. Runx I expression was associated with microglial activation and proliferation after injury, suggesting it could regulate these processes. We then investigated the hypothesis that Runxl induces proliferation and neuronal differentiation of adult NSPCs in primary adult mouse NSPC cullures. We provide evidence that Runxl acts as a pro-mitotic factor and can also promote neuronal fate choice in adult NSPCs. Taken together, our data suggest that Runxl is induced by injury and could drive post-injury neurogcnesis from a specific sub-population of adult
NSPCs. The Runx 1 pathway may therefore be a valuable target for manipulation in order to facilitate endogenous neurogcnesis following TB!.
VII Changes in adult neurogenesis after traumatic brain injury - the role of TGF-~ cytokines and the
transcription factor Runxl.
by
Trevor T. Logan
Dissertation submitted to the Faculty of the Neuroscience Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Doctor of Philosophy 2014 Curriculum Vitae Trevor Thomas Logan
Education
Graduate Education Currently a graduate student and PhD candidate in the Neuroscience program at the Uniformed Services University of the Health Sciences (USU). Completed qualifying examinations and advanced to PhD candidacy in Fall 2010. Current GPA: 3.69
Rotating labs: I) Lab of Dr. Zygmunt Galdzicki, where I focused on taking and analyzing field electrophysiology recordings of the rat hippocampus. 2) Lab of Dr. Maria Braga, where 1 worked on a project analyzing the effect of the chemical ROX on GABA receptor activity using whole-cell patch-elamp recordings of neurons in the rat amygdala. 3) Lab of Dr. Aviva Symes, where I worked on a project analyzing the ability of hepatocyte gro\.\'th factor to antagonize TGF-beta induced signaling in cultures of rat astrocytes.
Thesis lab: Dr. A \'i\'a Symes· lab. My graduate thesis examines changes in TGF-beta superfan1ily cytokine signaling in the adult neurogcnic regions after traumatic brain injury, the induction of a novel pro-neuronal differentiation transcription factor in adult NSC's after injury, and the effects of forced expression of this transcription factor in cultured adult neural stem cells.
Undergraduate Education Bachelor of Arts: Biology major with a minor in Neuroscience; Received Spring 2008 from St. Mary's College of Maryland, 20686 E. Fisher Road. St. Mary's City, MD 20686. GPA: 3.46.
High School Graduated from The John Carroll School in 2004. 703 Churchville Road, Bel Air, MD 21014
Publications
I) Villapol S. Yaszemski AK, Logan TT, Sanchez-Lemus E, Saavedra JM, et al. (2012) Candesartan. an angiotensin ll A T(l )-receptor blocker and PPAR-gamma agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology 37: 2817-2829. 2) Logan TT, Villapol S, Symes A. (2013) TGF-P superfamily gene expression and induction of the Runx 1 transcription factor in adult neurogenic regions after brain injury. PLoS ONE 8(3): e59250. doi: I 0.1371/journal.pone.0059250
3) Villapol S, Logan TT, and Symes A. (2013). Role ofTGF-P Signaling in Neurogenic Regions After Brain Injury, Trends in Cell Signaling Pathways in Neuronal Fate Decision, Dr Sabine Wislet-Gendebien (Ed.), ISBN: 978-953-51-1059-0, InTech.
4) Logan TT, Symes A. Runx 1 promotes proliferation and neuronal differentiation in adult mouse neurosphere cultures. Manuscript under review.
Grants and A wards Sigma Xi Grant-in-Aid of Research: Undergraduate research grant of $1000 awarded in Fall 2007.
USU Graduate Stipend: The Uniformed Service University offers stipends on a competitive basis to civilian doctoral students who are U.S. citizens or resident aliens. The stipends are $27,000 for entering students and $28,000 after advancement to candidacy. I received USU supported stipend upon entering the University in the Fall of 2008
Dean's Special Fellowship award at USU: A number of Dean's Special Fellowships are available on a competitive basis to recognize the outstanding scholarship and academic credentials of selected incoming students. The stipend for the Fellowship is the USU-supported graduate student stipend plus $5,000/year.
Henry Jackson Foundation Fellowship in Medical Sciences: The Henry Jackson Foundation for the Advancement of Military Medicine awarded two one-year student stipend fellowships for the academic year of 2013-2014. The fellowship is competitively awarded and is open to all graduate students in the Uniformed Services University. This award granted a stipend of $28,000 for one academic year, and $1000 travel support to attend and present findings at a scientific meeting.
TAB 16
Degree Granting: School of Medicine Graduate Programs
Omni Cassidy
UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799
September 5, 2014
MEMORANDUM FOR BOARD OF REGENTS ~-
Through: Charles L. Rice. M.D., President ~L l ·
SUBJECT: Certification of Graduate Student
The graduate student listed below is presented for certification to receive the Master of Science effective upon your approval:
Omni Cassidy
MASTER OF SCIENCE
Department of Medical and Clinical Psychology
Attached is the candidate's Dissertation Approval Form, certification of authorized use of copyrighted materials, Thesis Abstract, Thesis Title Page, and Curriculum Vitae.
Attachments: As stated
Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814
August 12, 2014
APPROVAL SHEET
Title of Dissertation: A Socio-ecological Conceptualization of Factors Promoting Excessive Weight Gain in Rural African Americans Girls: Considerations for Adapting Interpersonal Psychotherapy for the Prevention of Excessive Weight Gain for the Preventing Weight Gain and Enhancing Relationships in Underserved Populations (POWER-UP) Study
Name of Candidate: Omni Cassidy, Master of Science in Medical and Clinical Psychology,
08/04/2014
THESIS AND ABSTRACT APPROVED:
DATE:
Committee Chairperson
Tracy Sbrocco;Ph.D. DEPARTMENT OF MEDICAL & CLINICAL PSYCHOLOGY Thesis Advisor
Committee Member (Adjunct)
Gregory Mueller, Ph.D., Associate Dean (acting) II www.usuhs.mil/graded II [email protected] Toll Free: 800·772·1747 II Commercial: 301-295-3913 I 9474 II DSN: 295·9474 II Fax: 301-295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:
"A Socio-Ecological Conceptualization of Factors Promoting Excessive Weight Gain in
Rural African Americans Girls: Considerations for Adapting Interpersonal Psychotherapy for the
Prevention of Excessive Weight Gain" is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner.
Omni Cassidy Doctoral Program, Department of Medical & Clinical Psychology Uniformed Services University 08/3112014 ABSTRACT
Title of Thesis: A Socio-Ecological Conceptualization of Factors Promoting Excessive
Weight Gain in Rural African Americans Girls: Considerations for Adapting
Interpersonal Psychotherapy for the Prevention of Excessive Weight Gain
Omni Cassidy, BA, 2014
Thesis directed by: Tracy Sbrocco, Ph.D., Assistant Professor, Department of Medical &
Clinical Psychology
This thesis places-in broader context- African American girls who may be a vulnerable, high-risk group. While obesity and disordered eating prevention for rural African American girls is critical. efforts must be tailored to fit the given population. In doing so, researchers must carefully consider iii relevant, culturally specific factors precipitating obesity risk in these girls. Importantly, such risk factors must extend beyond the individual and capture broader social, cultural, and political influences. Collaborating with community members through community based participatory research (CBPR) may provide valuable insights regarding such factors and help improve acceptability and sustainability of the prevention program. Data will be presented from a CBPR qualitative study aimed to explore community members' perspectives on obesity, disordered eating behaviors, and an empirically supported excessive weight gain prevention program. The thesis concludes with a discussion of the various levels of risk factors highlighted by community participants and describes how data will be used to adapt the prevention program manual. iv A Socio-Ecological Conceptualization of Factors Promoting Excessive Weight Gain in Rural African Americans Girls: Considerations for Adapting Interpersonal Psychotherapy for the Prevention of Excessive Weight Gain by Omni Cassidy Thesis submitted to the Faculty of the Medical & Clinical Psychology Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Master of Science, 2014 Omni Cassidy ------EDUCATION Uniformed Services University of the Health Sciences, Bethesda, MD (August 2012 - present) Anticipated Graduation: May 2018 Clinical Psychology Doctoral Program Track: Medical & Clinical Psychology Washington University in St. Louis, St. Louis, MO (July 2006 - May 2010) Bachelor of Arts with Honors in Psychology Major: Psychology, Minor: Women and Gender Studies Cumulative GPA: 3.58/4.00; Major GPA: 3.63/4.00; Minor GPA: 3.90/4.00 Honors: Psi Chi - International Honor Society in Psychology, Dean's List, Eliot Scholar Jackson State University, Jackson, MS (June 2007 - July 2007) Summer Transient Student Cumulative GPA: 4.00/4.00 RESEARCH EXPERIENCE Graduate Student-Research Assis tant, Uniformed Services University (USU) Center for Health Disparities, Uniformed Services University of the Health Sciences (USU HS) , Bethesda, MD (August 2012 - present) Advisors: Tracy Sbrocco, Ph.D. & Marian Tanofsky-Kraff, Ph.D. • Assist Advisors in executing active laboratory projects related to 1) health disparities and obesity intervention among African American women and 2) eating disorder and obesity prevention in adolescent girls Research Assistant, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development!USUHS, Bethesda, MD (July 2010 - July 2012) Supervisors: Marian Tanofsky-Kraff, Ph.D. & Jack Yanovski, M.D., Ph .D. • Coordinated study testing the effectiveness of a psychotherapy program aimed to prevent excessive weight gain in adolescent girls at-risk for adult obesity and binge eating (MTK & JY) • Gathered focus group data and coordinated multi-site pilot trial to adapt a psychotherapy program to be more culturally appropriate in preventing excessive weight gain in Latina and African American girls who are at a disproportionate risk for adult obesity and binge eating using community-based participatory research methods (MTK) Research Intern, Jackson Heart Study, Jackson, MS (July 2009 -August 2009) Supervisor: Daniel Sarpong, Ph.D. • Investigated associations among spirituality/religiosity, social support, coping, stress, and glycemic control in African Americans Research Assistant, University of Miami, National Science Foundation Social, Behavioral, and Economic Sciences Summer Research Program, Coral Gables, FL (May 2008 - July 2008) Supervisor/Mentor: Frank Penedo, Ph.D. • Explored quality of life in prostate cancer survivors; Independent project: "Perceived stress mediates the relationship between spiritual well-being and depression in prostate cancer survivors" SELECTED PUBLICATIONS Cassidy, 0 , Sbrocco, T, Tanofsky-Kraff, M. (2014). Utilising non-traditional research designs to explore culture-specific risk factors for eating disorders in African-American adolescents. Advances in Eating Disorders: Theory, Research and Practice (in press). Cassidy, 0 , Sbrocco, T, Vannucci, A, Nelson, B, Heimdal, J, Mirza, N, Wifley, DE , Osborn, R, Shomaker, L, Young, JF, Waldron, H, Carter, M, Jackson-Bowen, D, Tanofsky-Kraff, M. (in press). Adapting Interpersonal Psychotherapy for the Prevention of Excessive Weight Gain in Rural African American girls. Journal of Pediatric Psychology [Special Issue on Innovative Treatment and Prevention Programs Addressing Pediatric Obesity]. Cassidy 2 Cassidy, OL, Matheson, 8, Osborn, R, Vannucci, A, Kozlosky, M, Shomaker, LB , Yanovski, SZ, Tanofsky-Kraff, M. (2012). Loss of control eating in African-American and Caucasian youth. Eating Behaviors, 13(2), 174-178. CLINICAL EXPERIENCE Psychology Extern, Mt. Washington Pediatric Hospital Baltimore, M.D. (August 2014 - Present) Supervisor: Erica Lee, Psy. D. • Conduct psychological assessments and therapy with children 5-17 years old who experience emotional or behavioral difficulties Psychology Extern, National Center for Weight and Wellness Washington, D.C. (January 2014 - May 2014) Supervisor/Co-leader: Robyn Osborn, Ph .D. Co-lead clinical therapy group for overweight and obese women with eating, weight, and mood related issues utilizing cognitive-behavioral and interpersonal psychotherapy techniques Graduate Student Leader and Clinical Interviewer, Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda, MD (September 2010 - Present) Supervisors: Marian Tanofsky-Kraff, Ph.D., Lauren B. Shomaker, Ph.D. • Co-lead cognitive-behavioral therapy and health education groups for overweighVobese adolescent girls at risk for Type II diabetes Provide health education to parent-child dyads of overweight youth at risk for obesity and disordered eating • Administer psychiatric interviews to assess general and eating-related psychopathology TEACHING EXPERIENCE Graduate Teaching Assistant, Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences Bethesda, MD (Fall 2014) Instructors: Tracy Sbrocco, Ph.D., & Marian Tanofsky-Kraff, Ph .D. • Assisted instructors in Psychopathology course for first-year doctoral students to develop competencies in identification and diagnosis of mental disorders, critical analysis of research and popular literature, and scientific writing skills Graduate Teaching Assistant, Department of Medical & Clinical Psychology, Uniformed Services University of the Health Sciences Bethesda, MD (Fall 2013) Instructor: Mark Ettenhofer, Ph.D. • Assisted instructor in Research Methods I course for first-year doctoral students to develop competencies in fundamental research methodology, critical analysis of research literature and designs, and strengthen scientific writing skills POLICY EXPERIENCE Work Group Member and Co-Editor, Peers for Progress, American Academy of Family Physicians Foundation, University of North Carolina-Chapel Hill Bethesda, MD (August 2013 - November 2013) • Assisted advisor (TS) in coordinating "Sustainability and Advocacy" work group tasked with building an economic case for local and national adoption of community health workers (CHWs) through healthcare reform and the Affordable Care Act and exploring effective models of advocacy for CHWs • Co-wrote and -edited workgroup product, "CHW Advocacy Toolkit: Changing Health Policy to Promote Sustainability" Graduate Teaching Assistant, Department of Medical & Clinical Psychology, Daniel K. Inouye Graduate School of Nursing, Uniformed Services University of the Health Sciences Bethesda, MD (Fall 2013-Winter 2013) Instructor: Patrick Deleon, Ph.D., J.D., M.P.H. • Assist instructor in Public Policy course for clinical psychology and nursing students with to introduce the use of research and clinical expertise in shaping public policy TAB 17 Degree Granting: School of Medicine Graduate Programs CPT Sarah McCreight UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 September 2, 2014 MEMORANDUM FOR BOARD OF REGENTS ~ · Through: Charles L. Rice. M.D., President dw..l L, J:: - SUBJECT: Certification of Graduate Student The graduate student listed below is presented for certification to receive the Master of Science effective upon your approval: CPT Sarah McCreight MASTER OF SCIENCE Department of Medical and Clinical Psychology Attached is the candidate· s Dissertation Approval Form, certification of authorized use of copyrighted materials, Thesis Abstract, Thesis Title Page. and Curriculum Vitae. ~Lrman n, MD, MP;{r) M Dean, USU, School of Medicine Attachments: As stated Prnned on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY, SCHOOL OF MEDICINE GRADUATE PROGRAMS Graduate Education Office (A 1045), 4301 Jones Bridge Road, Bethesda, MD 20814 July 24, 2014 APPROVAL SHEET Title of Dissertation: Program Outcomes and Soldier Perceptions of the Army Pregnancy and Postpartum Physical Training (P3T) Program Name of Candidate: Sarah J. McCreight, Master of Science in Medical and Clinical Psychology, Date: 07/24/2014 THESIS AND ABSTRACT APPROVED: DATE: £Wiry AND CLINICAL PSYCHOLOGY c~~ ~ Ph.D. DEPARTMENT OF MEDICAL AND CLINICAL PSYCHOLOGY Mi~hael Feuerstein, Ph.D. DEPARTMENT OF MEDICAL AND CLINICAL PSYCHOLOGY Committee Member Gregory Mueller, Ph.D., Associate Dean (acting) II www.usuhs.mil/graded JI [email protected] Toll Free: 800-772-1747 II Commercial : 301-295-3913 I 9474 II DSN : 295-9474 II Fax: 301-295-6772 The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled: PROGRAM OUTCOMES AND SOLDIER PERCEPTIONS OF THE ARMY PREGNANCY AND POSTPARTUM PHYSICAL TRAINTNG (P3T) PROGRAM is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner. ~r~~~ DEPARTMENT OF MEDICAL & CLINICAL PSYCHOLOGY Uniformed Services University July 24, 2014 ABSTRACT PROGRAM OUTCOMES AND SOLDIER PERCEPTIONS OF THE ARMY PREGNANCY AND POSTPARTUM PHYSICAL TRAINING (P3T) PROGRAM Sarah J. McCreight, M.S., 2014 Thesis directed by: Tracy Sbrocco, Ph.D., Associate Professor, Department of Medical and Clinical Psychology The Anny Pregnancy Postpartum Physical Training (P3T) Program is a mandatory exercise and education program that assists Army Soldiers in preventing excess antepartum weight gain, maintaining fitness during pregnancy, and meeting fitness and body composition standards postpartum. This study examined the relationship between program outcomes and perceptions of command support, program helpfulness, social support, and morale for 305 participants at Fort Campbell, Kentucky. Most participants perceived command support for Soldier participation. However, less than half of participants reported meeting fitness and body composition standards by 180 days postpartum and few believed P3T helped participants meet standards. Participants endorsed a number of positive social and retention-related program attributes, suggesting that P3T potentially improves confidence and morale, thereby improving retention of highly qualified female Soldiers who also choose to become parents. This evaluation provides insight into factors that may improve retention of highly qualified Soldiers, as well as considerations for future evaluations. ------PROGRAM OUTCOMES AND SOLDIER PERCEPTIONS OF Tl IE ARMY PREGNANCY AND POSTPARTUM PHYSICAL TRAINING (P3T) PROGRAM by Sarah J. Mccreight Thesis submitted to the Faculty of the Department of Medical and Clinical Psychology Graduate Program Uniformed Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Master of Science, 2014 Sarah J . Mccreight, MA Captain, U.S. Army Medical Service Corps PROFESSIONAL: PERSONAL: 4301 Jones Bridge Road Bethesda, MD 20814 (301) 295-3751 [email protected] EDUCATION Uniformed Services University of the Health Sciences (USU), Bethesda, MD In Progress Ph.D. in Clinical Psychology Anticipated graduation: May, 2016 Master's Thesis: Program outcomes and soldier perceptions of the Army Pregnancy and Postpartum Physical Training (P3T) Program. Under the direction of Tracy Sbrocco, Ph .D. East Carolina University (ECU), Greenville, NC 2010 M.A. in Clinical Psychology Master's Thesis: Online mental health services: Do women view this as a viable treatment option for sexual assault? Under the direction of Heather Littleton, Ph .D. East Carolina University (ECU), Greenville, NC 2001 B.A. in Psychology Institutional Honors: Magna Cum Laude CLINICAL EXPERIENCE USU DOCTORAL PROGRAM PRACTICA Tree House Child Assessment Center of Montgomery County, MD July 2013 - Jun 2014 Rockville, MD Hours: 16 per week Supervisor: Alicia Meyer, Ph.D. Fort Belvoir Community Hospital June-Aug 2013 Fort Belvoir, VA Hours: 16 per week Supervisor: Pamela Smith, Psy.D. Malcolm Grow Medical Clinic May 2012 - May 2013 Joint Base Andrews, MD Hours: 16-20 per week Supervisor: Rita Schonberg, Ph.D. USUHS National Patient Simulation Center Aug 2011 - Feb 2013 Silver Spring, MD Hours: 1 per week Supervisors: Claire DeLabar, Psy.D. & Jeannette Witter, Ph.D. ECU MASTER'S PROGRAM PRACTICA Cherry Hospital Jan - June 2006 Goldsboro, NC Hours: 16-20 per week Supervisor: Steven Peters, Psy.D. Womack Army Medical Center (WAMC) Behavioral Health Clinic Sept - Dec 2005 Fort Bragg, NC Hours: 16-20 per week Supervisor: Bradley Poppen, Ph.D. (L TC, U.S. Army) Special Forces Assessment and Selection Nov 2005 Camp Mackall/Fort Bragg, NC Hours: 10 Supervisors: Bruce Moyer, Psy.D. (MAJ, U.S. Army) & Mark Baggett, Ph.D. (COL, U.S. Army) Posttraumatic Stress Disorder Process Group Sept - Nov 2005 Fort Bragg, NC Hours: 1 every 2 weeks Supervisor: Bradley Poppen, Ph.D. (L TC, U.S. Army) TEACHING EXPERIENCE Health Equity Seminar, USU, Feb 2014 " Ethics in Research'', Research Methods II, Role: Preceptor USU, Dec 2012 Instructors: Mark Stephens, M.D. (CAPT., USN) Role: Guest Lecturer and Tracy Sbrocco, Ph.D. Instructor: David Krantz, Ph.D. Clinical Assessment II, USU, Feb - May 2013 Public Policy in the Context of Military & Role: Teaching Assistant Federal Health Care, USU, May - Aug 2012 Instructor: Layne Bennion, Ph.D. Role: Teaching Assistant Instructor: Pat DeLeon, Ph.D., J.D., M.P.H. Clinical Assessment I, USU, Nov 2012 - Feb 2013 Army Pregnanc y & Postpartum Physical Role: Teaching Assistant Training Program (P3T), Oct 2010 - May 2011 Instructor: Stan Ridley, Ph.D. Fort Wainwright, AK Role: Instructor Trainer/Program Manager RESEARCH EXPERIENCE USUHS Center for Health Disparities Funding Source: NIH Partnership with Army Institute of Public Health Feb 2012 - current Program evaluation of the Army's Pregnancy Postpartum Physical Training (P3T) program. Prevention of Obesity in Military Communities (POMC) Funding Source: DoD POMC: Mother-Baby, Fit-4-Duty, and Adolescent Projects Aug 2011 - present Prevention of Obesity in Military Communities (POMC), Program Project Grant Pl: Tracy Sbrocco, Ph.D. PUBLICATIONS & PROFESSIONAL PRESENTATIONS Tanofsky-Kraff, M., Sbrocco, T., Thiem, K. R. , Cohen, L. A., Mackey, E. R., Stice, E. , Henderson, J. L. , Mcc reight, S. J., Bryant, E. J., & Stephens, M. B. (2013). Obesity and the U.S. military family. Obesity, 21: 2205-2220. http://dx.doi.org/10.1002/oby.20566 Mccreight, S. J . (2013, May). The Army Pregnancy and Postpartum Physical Training (P3T) Program: A case study of Ft. Campbell, KY. Presentation to the Department of Medical and Clinical Psychology Seminar Series, Uniformed Services University of the Health Sciences, Bethesda, MD. Mccreight, S. J., Rawlings, J. A. , Jackson, T., Young, L. J. , & Sbrocco, T. (2013, May). Program evaluation plan for the Army Pregnancy and Postpartum Physical Training (P3T) Program. A poster presented to the Uniformed Services University of the Health Sciences Research Week, Bethesda, MD. Brewer, S. , Mirochnitchenko, D., Landenburger, A. , Mccreight, S., Barry, D., & Ettenhofer, M. (2012, May). Virtual reality driving assessment of combat exposure effects. A poster presented to the Uniformed Services University of the Health Sciences Research Week, Bethesda, MD. MILITARY PROFESSIONAL POSITIONS May 2001 - current 1 Assistant Brigade S6, 16 h Combat Aviation Brigade July 2010 - May 2011 Fort Wainwright, AK Battalion 56, 402nd Brigade Support Battalion June - December 2009 Kandahar Airfield, Afghanistan Executive Officer, 21•1 Signal Company Mar 2008 - June 2009 Fort Lewis, WA Platoon Leader, 21 •1 Signal Company Mar 2007 - Mar 2008 Fort Lewis, WA Selectee, Green to Gold, Active Duty Option Aug 2004 - July 2006 East Carolina University, Greenville, NC Communications Security Analyst/Senior Watch Officer Feb 2002 - July 2004 National Security Agency, Joint COMSEC Monitoring Activity, Linthicum Heights, MD TAB 18 Degree Granting: School of Medicine Graduate Programs CPT Matthew Moosey UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 September 2, 2014 MEMORANDUM FOR BOARD OF REGENTS ~ Through: Charles L. Rice, M.D., President ~ L· SUBJECT: Certification of Graduate Student The graduate student listed below is presented for certification to receive the Master of Science effective upon your approval: CPT Matthew Moosey MASTER OF SCIENCE Department of Medical and Clinical Psychology Attached is the candidate's Dissertation Approval Form. certification of authorized use of copyrighted materials, Thesis Abstract Thesis Title Page. and Curriculum Vitae. C!j ellermann, MD, ~l~ Dean, USU. School of Medicine Attachments: As stated Printed on @ Recycled Paper UNIFORMED SERVICES UNIVERSITY OF THE H EALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDIC INE 4301 JONES BR I DGE ROAD BETH ESDA, MARYLAND 20814-4799 July29, 2014 GRADUATE PROGRAMS I N THE BIOM EDICAL SCIENCES AND PUBLIC HEALTH APPROVAL SHEET Ph.D. Degrees Title of Thesis: "Effects of Nicotine and Stress on Anxiety-related lnterdisciplinat) and Depression-related Behavior in Rats" -Emerging Infectious Diseases -Molecular & Cell Bioloro -Neuroscience Name of Candidate: Matthew J. Moosey Clinical Psychology Departmental -Clinical Psychology Master of Science -Environmental I lealth Sciences July 29, 2014 -Medical PS)chology -Medical Zooloro· Ph)sician Scientist (MDfPh.0.) Thesis and Abstract Approved: Doctor of Public I lea Ith (Dr.P.H.) Master ofScie11ce Degrees -Public I lcalth Neil E. Grunberg, Ph. Masters Degrees Department of Medi ca linical Psychology Thesis Advisor -Milital) Medical History -Public I lcalth -Tropical Medicine & Hygiene Graduate Educatio11 Office ~/!~ Andr Web Site http:/ ''"'' .usuhs.mil gradcdf httQ' u'uh' mil gco gradpgm inde,,html 1~~(~1 anette Witter, Ph.D. ~ E-mail Address epartment of Medical and Clinical Psychology !m!duat.;program ll usuhs.mil Committee Member Plto11e Numbers Commercial: 301-295-9474 Toll Free: 800-772-1747 DSN: 295-9474 FAX: 301-295-6772 COPYRIGHT STATEMENT The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled: Effects ofNicotine and Stress on Anxiety-related and Depression related Behavior in Rats is appropriately acknowledged and, beyond brief excerpts, is with the permission of the copyright owner. [Signature] Matthew J. Moosey July 30, 2014 v ABSTRACT Title of Thesis: Effects of Nicotine and Stress on Anxiety-related and Depression-related Behavior in Rats Matthew J. Moosey, Master of Science, 2014 Thesis directed by: Neil E. Grunberg, Professor, MPS Current cigarette use in the U.S. includes roughly 20% of civilian adults, 30% of Anned Forces personnel, and a majority of psychiatric patients. Tobacco use by American Warriors deployed to Iraq and Afghanistan is estimated at approximately 50%, despite widespread knowledge of the health risks associated with tobacco use. Two animal (rat) experiments were conducted to examine whether nicotine, the drug of addiction in tobacco, decreases anxiety-related and depression-related behavior. In Experiment 1, rats (male and female, Sprague-Dawley rats) were exposed to the Warrior Stress Paradigm (a paradigm that mimics the threat of death and environmental stressors experienced by Warriors in combat) and nicotine was delivered via SC implc~mted osmotic mini pumps at three levels of nicotine dosages (0, 3, and 6 mg nic/kg/day). Planned comparisons between saline controls and unstressed female rats in the 6 mg nic/kg/day nicotine condition demonstrated less depression-related behavior at certain time points, yet these findings for females (and not males) were preliminary and warranted replication. There were no anxiolytic effects of nicotine in the first experiment. A second experiment used four dosages of nicotine (0, 3, 6, 9 mg nic/kg/day) and failed to find clear anti-depressant effects of nicotine. Future studies could use varying levels of Vl Warrior stress or different predatory stressors to investigate how sex may moderate the anxiolytic or anti-depressant properties of nicotine, which may inform tobacco cessation treatment in male and female Warriors. VII Effects of Nicotine and Stress on Anxiety-related and Depression-related Behavior in Rats by Matthew J. Moosey Thesis submitted to the Faculty of the Medical and Clinical Psychology Graduate Program Unifonned Services University of the Health Sciences In partial fulfillment of the requirements for the degree of Master of Science, 2014 MATTHEW J. MOOSEY EDUCATION Uniformed Services University of the Health Sciences, Bethesda, Maryland Ph.0. in Clinical Psychology Projected Graduation 2015 Uniformed Services University of the Health Sciences. Bethesda. Maryland M.S. in C linical Psychology 201-t Master·s Thesis: Effects of Nicotine and Stress on Anxiety-related and Depression-related Behavior in Rats Chicago School of Professional Psychology, Chicago, Illinois M.A. in Forensic Psychology 2009 Master's Project: Integrated Morale Management for Small Units United States Military Academy, West Point, New York B.S. in International Politics 2005 Areas of Concentration: Middle Eastern Politics Minor: Nuclear Engineering TEACHING EXPERIENCE Co-course Director, Appetitive Behaviors Winter 2013-Present Co-directed a 12-lesson graduate student seminar on Appetitive Behaviors, USU Graduate School. Collaborated with Professor Neil Grunberg on curriculum development, course assessments, lecture presentation, on selected topics in Appetitive Behaviors, Motivation, related theories. Preceptor for Military Medical Leadership, USU School of Medicine Fall 2013-Present Facilitator, trainer, and mentor to first and second year medical students and advanced graduate nursing students on selected topics in military medical leadership including communication for leaders and essentials of leadership for the Department of Mi Iitary and Emergency Medicine. Teaching Assistant for Medical Psychology, USU School of Medicine Fall 2013 Collaborated with Professor Neil Grunberg and USU Medical School faculty to develop curriculum, assessments, and lectures for first year medical students in Medical Psychology for the Fundamentals of Medicine Module. Teaching Assistant to Professor eil E. Grunberg, Ph.D. 2012 - 2013 Collaborated with Professor Grunberg with lecture presentation development, curriculum assessment, and lecture presentation logistics for medical student education in the following topics: Fundamentals of Learning. Fundamentals of Stress. and Tobacco Use. Teaching Assistant to Professor Paul Rapp, Ph.D. Fall 2012 Collaborated with Professor Rapp with syllabus and curriculum development, and lecture presentation for a 12-lesson graduate student seminar on psychophysiology. MATTHEW J MOOSEY PAGE Z RESEARCH EXPERIENCE Consortium for Health and Human Performance- Panel Co-Chair May 2014 Panel Co-Chair for a multi-disciplinary ·'Women in Combat'' conference held at the Defense Health Agency. Co chaired with Professor Mady Segal. Professor Emeritus. University of Maryland on several topics related to integrating female Warriors into 21"' Century combat. including leadership communications and the role of psychologists in military gender integration. Bushmaster Activities Research Group- Member August 2012-Present Member of an inter-disciplinary research group focusing on improving military medical officer education at USU through the development of Operation Bushmaster, a week-long field training exercise (FTX) for advanced fourth year medical students. Also participated as faculty for Operation Bushmaster as Leadership Observer-Controller (OC). Behavior, Environment, Anxiety, Threat and Nicotine (BEAT-Nie) August 2012-Present Lead graduate student on a study examining the bio-behavioral effects of environmental and predator stress on male and female Sprague-Dawley rats administered a sustained nicotine dose through subcutaneously implanted osmotic mini-pumps. Measurements of anxiety and depression like behavior. including collecting blood and brain samples for conisol and neuronal competency analysis. Questionnaire Implementation Team (USU-QulT) August 2012-Present Collaborated with Professor Carlo DiClemente, University of Maryland-Baltimore county, on a multi-disciplinary research team to develop and implement a brief. 20-question survey instrument to assess the attitudes and tobacco-related behavior of patients and staff within nearly 900 state- owned mental health and substance abuse clinics within the State of Maryland. Grunberg Research Laboratory August 2011-Present Responsible for a wide range of research related duties within Professor Grunberg's research group including performing behavioral measures of animal behavior. collecting blood and brain samples, conducting literature review, and editing papers. Collaborated and acted as lab liaison to Professor Marini's Soman nerve agent study. Completed lab safety training, blood borne pathogen tra in ing, animal handling and ethical research (CIT!) training. PUBLICATIONS Moosey, M. (2013) Effects of Nicotine and Stress on Anxiety-related and Depression-related behavior in rats (Master's thesis). Uniformed Services University of the Health Sciences, Bethesda. MD. Moosey, M., Barry. E.S., Finton, B.J., Graham, A., Weisbrod, A., Yarnell, A.M .. Grunberg, N.E. (2013, May) Behavior, Environment, Affect, Threat and Nicotine (BEAT-Nie). Presented at USUHS Research Days, May 15-16, 2013. Bethesda. MD. Woodson. J., Barry, E.S., Finton, B.J., Moosey. M., Weisbrod, A., Yarnell, A.M., & Grunberg. N.E. (2013, May) Bushmaster Research Activities Group (BRAG). Presented at USUHS Research Days. May 15-16, 2013, Bethesda, MD. PROFESSIONAL EDUCATION 2014 - Level I Certification, Eye Movement Desensitization and Reprocessing (EMDR), EMDR Institute, Watsonville, CA 20 I0 - Graduate, Army Medical Department Advance Course, Ft Sam Houston, fX 2005 - Graduate, Mounted Officer Basic Course, Ft Knox. KY TAB 19 USU Faculty Appointments and Promotions School of Medicine UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F. EDWARD HEBERT SCHOOL OF MEDICINE 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 208144712 http://www.usuhs.mil OFFICE OF THE DEAN September I I, 2014 MEMORANDUM FOR BOARD OF REGENTS SUBJECT: Faculty Appointments The attached are recommendations made by the Committee of Appointments, Promotion and Tenure at a meeting on August 26, 2014. I recommend tbat you approve these recommendations and forward them to the President of the University for further action. Arthur211~~ L. Kellermann, MD, MPH .Professor and Dean, School of Medicine Attachments Learning to Care for Those in flarm's Way 1 PROPOSED FACULTY RECOMMENDATIONS October 14, 2014 BOARD OF REGENTS ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION Primary Appointments (Billeted) FAMILY MEDICINE LEGGIT, Jeffrey Associate Professor Promotion COL, MC, USA Non-Tenure USUHS SERVEY, Jessica Associate Professor Promotion Col, USAF, MC Non-Tenure USUHS PHARMACOLOGY BAUSCH, Suzanne Professor Promotion Ph.D. With Tenure USUHS 2 ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION Primary Appointments (Non-Billeted) MEDICINE ACOSTA, Ruben Associate Professor Promotion LCDR, MC, USN Non-Tenure WRNMMC BASSETT, John Associate Professor Promotion CDR, MC, USN Non-Tenure WRNMMC BATTAFARANO, Daniel Professor Promotion D.O. Non-Tenure Ft. Sam Houston, TX BLAYLOCK, Barbara Clinical Associate Professor Promotion M.D. Non-Tenure Rockville, MD DORRANCE, Kevin Associate Professor Promotion CAPT, MC, USN Non-Tenure WRNMMC EVANS, Neil Clinical Associate Professor Promotion M.D. Non-Tenure Washington, DC KERR, Gail Clinical Professor Appointment M.D. Non-Tenure Washington, DC MAKARY, Zizette Clinical Associate Professor Promotion M.D. Non-Tenure WRNMMC NELSON, Michael Professor Promotion COL, MC, USA Non-Tenure WRNMMC OSSWALD, Michael Clinical Professor Promotion M.D. Non-Tenure Ft. Sam Houston, TX PEPPER, Patricia Associate Professor Promotion CAPT, MC, USN Non-Tenure San Diego, CA RAMSEY, Robert L. Clinical Professor Promotion M.D. Non-Tenure WRNMMC 3 ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION RICHARDS, John Clinical Associate Professor Promotion M.D. Non-Tenure Washington, DC RITTER, Joan Clinical Professor Promotion M.D. Non-Tenure WRNMMC WHITMAN, Timothy Associate Professor Promotion CDR, MC, USN Non-Tenure WRNMMC WOOL, Ronald Clinical Associate Professor Appointment COL, MC, USA Non-Tenure Ft. Sam Houston, TX MILITARY/EMERGENCY MEDICINE BEBARTA, Vikhyat Professor Promotion Lt Col, USAF, MC Non-Tenure Ft. Sam Houston, TX NEUROLOGY KENNEY, Kimbra Associate Professor Promotion M.D. Non-Tenure Rockville, MD PATHOLOGY BRISSETTE, Mark Associate Professor Appointment M.D. Non-Tenure Silver Spring, MD GRIEDER, Franziska Adjunct Associate Professor Appointment Ph.D. Non-Tenure Bethesda, MD PSYCHIATRY BLACK, Nancy Clinical Associate Professor Promotion M.D. Non-Tenure Washington, DC BRASINGTON, Steve Clinical Associate Professor Appointment CAPT, MC, USN Non-Tenure Bethesda, MD 4 ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION MATECZUN, John Clinical Professor Promotion M.D. Non-Tenure Davidsonville, MD REGIER, Darrel Adjunct Professor Appointment M.D. Non-Tenure Bethesda, MD SURGERY BODO, Michael Adjunct Associate Professor Appointment M.D. Non-Tenure Silver Spring, MD BONO, Raquel Clinical Professor Appointment RDML, MC, USN Non-Temure Bethesda, MD CABLE, Benjamin Professor Promotion COL, MC, USA Non-Tenure Honolulu, HI COLYER, Marcus Associate Professor Promotion MAJ, MC, USA Non-Tenure WRNMMC COPELAND, Annesley Associate Professor Promotion M.D. Non-Tenure USUHS GROSS, Kirby Associate Professor Promotion COL, MC, USA Non-Tenure WRNMMC GWINN, David Associate Professor Promotion CDR, MC, USN Non-Tenure WRNMMC MCCAFFERTY, Randall Associate Professor Appointment Col, USAF, MC Non-Tenure Ft. Sam Houston, TX 5 ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION Secondary Appointments (Billeted) NEUROSCIENCE BAUSCH, Suzanne Professor Promotion Ph.D. Non-Tenure USUHS 6 ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION Secondary Appointment (Non-Billeted) PEDIATRICS NELSON, Michael Professor Promotion COL, MC, USA Non-Tenure WRNMMC PREVENTIVE MEDICINE & BIOMETRICS WITKOP, Catherine Adjunct Associate Professor Appointment Lt Col, USAF, MC Non-Tenure McLean, VA 7 ACTION/CURRENT DEPARTMENT/NAME PROPOSED RANK DUTY STATION Emeritus Appointment PATHOLOGY Friedman, Robert Emeritus Professor M.D. TAB 20 USU Faculty Appointments and Promotions Postgraduate Dental College UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES POSTGRADUATE DENTAL COLLEGE 2787 Winfield Scott Road, Suite 220, Building 2398 JBSA Fort Sam Houston, Texas 78234 OFFICE OF TIIE DEAN 5 September 2014 MEMORANDUM FOR BOARD OF REGENTS SUBJECT: Faculty Appointments, Postgraduate Dental College The attached is the recommendation made by the Postgraduate Dental College's Committee on Appointments and Promotions (PDC CAP) at a meeting on Appointments and Promotions on 4 September 2014. I recommend that you approve this recommendation and forward it to the President of the University for further action. fb_ti9i-., Patrick D. Sculley.DDS, MA Executive Dean and Professor Postgraduate Dental College Attachments Learning to Care for Those in Harm~ i:#iy POSTGRADUATE DENTAL COLLEGE FACULTY RECOMMENDATIONS September 4, 2014 BOARD OF REGENTS ACTION/CURRENT SCHOOL/NAME PROPOSED RANK DUTY STATION Air Force Postgraduate Dental School David Lee Associate Professor Appointment Lt Col, USAF, DC JBSA - Lackland, TX Ryan Snyder Associate Professor Promotion LTC, DC, USA JBSA - Lackland, TX Navy Postgraduate Dental School Jeffrey Wessel Associate Professor Appointment LCDR, DC, USN Bethesda, MD TAB 21 Awards and Honors Naming of the Chair of Pathology UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http://www.usuhs.mil 9 September 2014 MEMORANDUM FOR THE PRESIDENT, USU TI IROUGI I: USU BOARD OF REGENTS SU BJ ECT: Naming of the Chair of Pathology in Honor of Dr. Robert Friedman The USU Names and Honors Committee fully supports the naming of the School of Medicine Chair of Pathology in honor of Dr. Robert Friedman for his continuous 33 years of dedicated service to the University. As the founding Chair of Pathology. Dr. Friedman built a robust academic department generating knowledge through research, and laying the foundation for the education of physician graduates as well as research scientists. I lis own research involving the ability of Interferon to cause differentiation of tumor cells has been groundbreaking. I !is efforts continue even today to ensure the University is a shining example of the excellence here at USU. Thank you for your consideration. L. Andrew Huff. Col. USAF. i\IC. SFS Dircdor. AFRR: Chair. CSL: Names&. llonors C\rn11111ttee L earning to Care for Those in H arm's 1#ly UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES F.EDWARD HEBERT SCHOOL OF MEDICINE America's Medical School 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4799 http://www.usuhs.edu OFFICE OF THE DEAN September 4, 2014 MEMORANDUM FOR COL LESTER HUFF, CHAIR, NAMES AND HONORS COMMITTEE SUBJECT: Title change of the Chair of Pathology Dr. Robert M. Friedman, the founding Chair of Pathology, will officially retire on January 9, 2015 after 33 years of service. During his time of service at USU, Dr. Friedman had built a robust academic department generating knowledge through research, and laying the foundation for the education of physician graduates as well as research scientists. I Iis own research involving the ability ofinterferon to cause differentiation of tumor cells has been groundbreaking. Dr. Friedman has served as an exemplar to his fellow chairs and faculty. As a result, I recommend the title of Chair of Pathology be changed to the Robert M. Friedman Chair of Pathology to honor his positive impact on the Department of Pathology, the School of Medicine, and the Uniformed Services University of the Ilealth Sciences. Arthur L. Kellermann, M.D., M.P.H. Professor and Dean HIGHLIGHTS FROM CV OF DR. ROBERT FRIEDMAN The first research I completed employed methotrexate to inhibit immunological responses. When I found that I was able to suppress both humoral and cellular immunity in animals, I showed that virus infected animals treated with methotrexate recovered, but they still produced interferon. This was one of the first demonstrations that interferons have a role in the recovery of animals from primary virus infections. My research then was devoted to the mechanism of action of interferons. In order to carry out this project, I had to elucidate some of the mechanisms of virus replication in cells, and then see if the steps I had uncovered were altered in interferon treated cells. It finally became clear that progress in this field depended on developing a cell free system showing interferon-induced inhibition of virus activity. I helped to develop such a system working with Ian Kerr at Mill Hill in London. This work has proved to be important in the development of research on regulation of cell activities. My next project was to study the activity of interferons on membrane associated viruses. Several unique activities were found in these systems. The most important finding, however, was the observation that interferons could suppress virus growth in chronically infected cells. This basic research was applied in clinical studies that used interferon to treat viral hepatitis infections. My current research is concerned with an observation that interferon can induce reversion of transformed cells in cultures. We have established that the mechanism involved depends on the induction of the activity of the gene for lysyl oxidase. I am currently investigating the mechanism for this activity which appears to involve methylation of DNA sites. SCIENTIFIC CONTRIBUTIONS of DR. ROBERT FRIEDMAN Dr. Friedman has carried out research in three areas: immunology, virology, and studies on interferons (numbers refer to citations in his bibliography) I. Studies on interferons: a. Biology of interferons - one of the first reports that interferons are important in recovery from primary virus infections (8, 27) b. Clinically relevant studies on interferons. 1. Interferons are produced in patients with SLE and HIV Infections (177, 178, 187, 197) 2. Interferon gamma inhibits malaria and mycotic infections (220,232, 234) 3. Inhibition of HIV growth by interferons (243, 244, 245, 249, 250) c. Mechanisms of interferon synthesis (34, 35, 38, 49, 57, 73, 76, 134, 164, 263, 270) d. First reports that cell protein synthesis is required for interferon activity (20, 26, 180) e. Inhibition of viral protein and nucleic acid synthesis by interferons (25, 32, 33, 36, 123) f. Interferon regulates production of hemoglobin epsilon (251) g. Reports of the first cell free system for antiviral action of interferon (82, 84, 88, 180) h. Studies on interferon inhibition of membrane-associated viruses. These studies were important because they demonstrated that interferons were useful in the inhibition cells chronically infected with viruses and were used to justify the employment of interferon in the treatment of chronic Hepatitis B and C infections. (94, 95, 96, 99, 101, 103, 104, 106, 109, 112, 116, 125, 126, 128, and fifteen additional papers) I. Reversion of transformed cells by interferon; importance of the gene for lysyl oxidase (179, 192, 198, 201, 259, 262, 265, 266, 267, 271, 275 and twelve additional papers) II. Immunology. Early demonstration that cellular and humoral immunity could be inhibited by an antimetabolite methotrexate (4, 13, 15, 19, and 28) Ill. Virology. Studies on viral RNA and protein synthesis in infections with an arbovirus (22, 23, 43, 44, 45, 46, 47, 48, 50 51, 53, 54, 63, 64, 68, 71, 80, 81, 130, 151, 152, 156, and 212) CURRICULUM VITAE Name: Robert M. Friedman, M.D. Date & Place of Birth: Licensure: California Certificate #69268 Citizenship: United States Education: 1954 - A.B., with honors, Cornell University 1958 - M.D., New York University College of Medicine Board Certification: 1965 - Diplomate, American Board of Pathology Fellow, College of American Pathologists (FCAP) Brief Chronology of Employment: 1958-1959 - Rotating Intern, The Mount Sinai Hospital, New York 1959-1961 - SA Surgeon, USPHS, Div. of Biologic Standards, NIH 1961-1963 - Resident in Pathologic Anatomy, NCI 1963-1964 - Visiting Scientist, Virology & Bacteriology Laboratory National Inst. for Medical Research, Mill Hill, London with Dr. Alec Isaacs 1965-1970 - Medical Officer, Laboratory of Pathology, NCI, NIH 1965-1983 - Faculty, the Foundation for Advanced Education in the Sciences, Inc., Bethesda, MD Teaching courses in immunology, pathology, and virology 1969-1973 - Head, Viral Oncology and Molecular Pathology Section, Laboratory of Pathology, NCI, NIH, Bethesda, MD 1971-1973 - Visiting Scientist, Biochemistry Department, National Institute for Medical Research, Mill Hill, London 1973-1982 - Medical Director, USPHS 1973-1981 - Head, Section on Chemical Pathology, Laboratory of Experimental Pathology, NIAMDD, NIH, Bethesda, Md. 1976-1981 - Chief, Laboratory of Experimental Pathology, NIAMDD,NIH, Bethesda, MD 1981 - Royal Society Visiting Scientist, Department of Biological Sciences, University of Warwick 1981- 2014 - Chairman, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Md. Societies: Phi Beta Kappa Alpha Omega Alpha Phi Kappa Phi American Association of Immunologists American Society for Microbiology American Society for Experimental Pathology American Association of University Pathologists (Pluto Club) 1 Honors, Other Special Scientific Recognition, and Public Service: 1950 - New York State Scholarship Cornell University Scholarship 1955 - New York State Medical Scholarship 1963-64 - visiting Scientist, Natl. Institute for Medical Research, Mill Hill, UK 1966 - Representative, Joint Japan-American Conference on Tuberculosis 1969 - Representative, Joint Japan-American Conference on Interferon 1970 - 90. - Contract Review Officer for NIH and Contract Consultant Officer 1970 - 1986 - Editorial Board, Journal of Virology 1970 - Elected to American Association of University Pathologists 1971 - McLaughlin Lecturer, The University of Texas Medical Branch, Galveston, Texas 1973, 1988, 1991 - Member, Program Committee, American Society of Experimental Pathology 1973 - Member, Public Information Committee, Federation of American Societies for Experimental Biology 1971-3 – Visiting Scientist, National Institute for Medical Research, Mill Hill, UK 1973 - 1976 - Member, Infectious Disease Committee, National Institute of Allergy & Infectious Disease 1974 - 1980 - Contract Officer, National Cancer Institute 1975 - 1982 - Consultant, Antiviral Substances Program, NIAID 1978 - 1981 - Editorial Board, Virology 1979 - 1983 - Editorial Board, Archives of Virology 1980 - 1984 - Editorial Board, Infection & Immunity 1984 - 1990 - Editorial Board, Journal of Immunology 1981 - One of 1,000 most-cited scientists 1965-1978. Current Contents. Oct. 12, 1981 1983 - 1992 - Editor-in-Chief, Journal of Experimental Pathology 1989 - Consultant, Assistant Secretary of Defense, Health Affairs 1991- Royal Society Fellow, Warwick University, UK 1992 - Adjunct Professor of Pathology, Georgetown University 1992 - Mellanby Memorial Lecturer, Central Drug Research Institute, Lucknow, India, February 17, 1992 1993- NIH representative to Hungary to evaluate biomedical research programs. 1993 - Visiting Professor, Department of Cancer Biology, Cleveland Clinic Foundation 1993 - Alumni Leadership Award, NYU School of Medicine 1994 - pres Member, Board of Governors, NYU School of Medicine Alumni 1994-5 - Secretary, International Society for Interferon & Cytokine Research (ISICR) 1996-2006. Member, Scientific Advisory Board, Armed forces Institute of Pathology 1996- Member, Academy of Medicine of Washington, DC 1996-97 - President, ISICR 2003 - Elected Honorary Member, ISICR 2004 – Cited by US Dept. of State for supervision of USUHS program and activities in India. 2005 – Visiting Scientist, Centro Nacional de Biotecnologia, Madrid, Spain 2012 - Distinguished Service Award – ISICR 2014 – Solomon Berson Award for Research from NYU Medical School I have also served from time to time as a visiting lecturer at several universities and research institutes, and as a book reviewer or ad hoc editorial consultant for several professional journals. 2 Research Interests: pathology, virology, immunology, & oncology. Home Address: Research Grants: My work has been well-supported in the past by grants from the NIH, The Kroc Foundation, The American Society for AIDS Research, and the U.S. Army Medical Research and Development Command. At present my research on differentiation therapy of cancer is supported by funds from The Henry M. Jackson Foundation for the Advancement of Military Medicine.. 3 BIBLIOGRAPHY 1. Adams, E., Friedman, R.M., and Goldstone, A.: Animal metabolism of hydroxyproline: isolation and enzymatic reactions of -hydroxy-glutamic semialdehyde. Biochem. Biophys. Acta 30:212, 1958. 2. Kirschstein, R., Borman, C., Baron, S., Friedman, R.M., Murray, R., and Hottle, G.: Laboratory investigations of the attenuated polio-virus vaccine strains. I. Neurovirulence after intramuscular inoculation of monkeys, Live Poliovirus Vaccines, Second International Conference of the Pan American Health Org. 50:90, 1960. 3. Baron, S., Friedman, R.M., Kirschstein, R., Borman, G., Murray, R., and Hottle, G.: Laboratory investigations of the attenuated polio-virus vaccine strains. II. Tissue culture characteristics before and after gastrointestinal passage, Live Poliovirus Vaccines, Second International Conference of the Pan American Health Org. 50:124, 1960. 3a Friedman, R.M.: Chick cell agglutinating unit. New E. Journal of Med. 264 (3): 153, 1961 4. Friedman, R.M., Buckler, C., and Baron, S.: The effect of amino-methylpteroylglutamic acid on the development of skin hypersensitivity and on antibody production in guinea pigs. J. Exp. Med. 114:173, 1961. 5. Friedman, R.M., and Baron S.: The role of antibody in recovery from infection with vaccinia virus. J. Immun. 87:379, 1961. 6. Hiatt, C.W., Gerber, P., and Friedman, R.M.: Photodynamic inactivation of the vacuolating virus, SV40. Proc. Soc. Exp. Biol. Med. 109:230, 1962. 7. Baron, S., Nasou, J., Friedman, R.M., Owen, G., Levy, H., and Barnett, E.: Antibody production by hypogammaglobulinemic patients. J. Immun. 88:443, 1962. 8. Friedman, R.M., Baron, S., Buckler, C., and Steinmuller, R.: The role of antibody delayed hypersensitivity and interferon production in recovery of guinea pigs from primary infection with vaccinia virus. J. Exp. Med. 116:347, 1962. 9 Friedman, R.M., Kirschstein, R., Borman, G., and Robbins, F.: Characteristics of Sabin type I poliovirus after gastrointestinal passage in newborn infants. I. Monkey neurovirulence and temperature marker findings. Am. J. Hyg. 76:137, 1962. 10. Friedman, R.M., Rabson, A.S., and Kirkham, W.: Variation in interferon production by polyoma virus strains differing oncogenicity. Proc. Soc. Exp. Biol. Med. 112:347, 1963. 11. Baron, S., Friedman, R.M., and Buckler, C.E.: Characterization of monkey CNS factor which inhibits poliovirus growth. Proc. Soc. Exp. Biol. Med. 113:107, 1963. 4 12. Friedman, R.M., Holtz, A.I., Baron, S., Silbergeld, S., and Buckler, C.E.: Studies on rapid immunization with mumps vaccine. Am. J. Hyg. 78: 269, 1963. 13. Friedman, R.M., and Buckler, C.E.: Methotrexate inhibition of tuberculin hypersensitivity. J. Immun. 91:846, 1963. 14. Friedman, R.M., and Rabson, A.S.: Possible role of interferon in determining the oncogenic effect of polyoma virus variants. J. Exp. Med. 119: 71, 1964. 15. Brandriss, M.W., Smith, J.W., and Friedman, R.M.: Suppression of EAE by methotrexate. Ann. N.Y. Acad. Sci. 122:356, 1965. 16. Friedman, R.M.: Role of interferon in viral interference. Nature 201:848, 1964. 17. Friedman, R.M., and Steigbiegel, N.: Histiocytic medullary reticulosis. Am. J. Med. 38:130, 1965. 18. Friedman, R.M., and Rabson, A.S.: Polyoma virus strains of differing oncogenicity: Transplantation immunity in mice. Virology 23:273, 1964. 19. Friedman, R.M.: Inhibition of established tuberculin hypersensitivity by methotrexate. Proc. Soc. Exp. Biol. Med. 116:471, 1964. 20. Friedman, R.M., and Sonnabend, J.A.: Effect of p-fluorophenylalanine on interferon action. Nature 203:366, 1964. 21. Friedman, R.M., and Roberts, W.C.: Myocardial embolization. A complication of mitral valvulotomy. New Eng. J. Med. 272:251, 1965. 22. Sonnabend, J.A., Delgarno, L., Friedman, R.M., and Martin, E.M.: A possible replicative form of Semliki Forest Virus. Biochem. Biophys. Res. Comm. 17:455, 1964. 23. Friedman, R.M., and Sonnabend, J.A.: Inhibition by interferon of production of double stranded Semliki Forest Virus RNA. Nature 206:532, 1965. 24. Sabesin, S.M., and Friedman, R.M.: Absence of cellular localization of antigen in delayed hypersensitivity. Proc. Soc. Exp. Biol. Med. 118:838, 1965. 25. Friedman, R.M., Sonnabend, J.A., and McDevitt, H.: Interferon inhibition of cytoplasmic DNA accumulation in vaccinia virus infection. A radioautographic study. Proc. Soc. Exp. Biol. Med. 119:551, 1965. 25a. Friedman, R. M. Effect of interferon treatment on interferon production. J. Immunol. 96: 872-77. 1966 5 26. Friedman, R.M., and Sonnabend, J.A.: Inhibition of interferon action by puromycin. J. Immun. 95:696- 703, 1965. 27. Baron, S., Buckler, C.E., and Friedman, R.M.: Role of circulating interferon in resistance to virus infections. J. Immun. 96:17-24, 1966. 28. Allison, A.C., and Friedman, R.M.: Antitumor immunity in the pathogenesis of tumors of rabbit fibromatosis. J. Nat. Cancer Inst. 36:859-868, 1966. 29. Friedman, R.M., Sonnabend, J.A., and Baron, S.: Interferon and virus infections. In Allison, A. (Ed.): Penguin Science Survey B 1966, London, England, Cox and Wyman Ltd., 1966, pp. 135-147. 30. Sonnabend, J.A., and Friedman, R.M.: Mechanism of interferon action. In Finter, N.B. (Ed.): Interferons, Amsterdam, North-Holland Pub. Co., 1966, pp. 202-231. 31 Friedman, R.M.: Interferon production and protein synthesis in chick cells. J. Bact. 91:1224-1229, 1966. 32. Friedman, R.M., Levy, H.B., and Carter, W.B.: Replication of Semliki Forest Virus: Three forms of viral RNA produced during infection. Proc. Nat. Acad. Sci. 56:440-446, 1966. 33. Friedman, R.M., and Berezesky, I.K.: Cytoplasmic fractions associated with Semliki Forest Virus RNA replication. J. Virol. 1:374-383, 1967. 34. Friedman, R.M.: Interferon binding: The first step in establishment of antiviral activity. Science 156:1760, 1967. 35. Friedman, R.M., and Cooper, H.L.: Stimulation of interferon production in human lymphocytes by mitogens. Proc. Soc. Exp. Biol. Med. 125:901, 1967. 36. Friedman, R.M., Fantes, K.H., Levy, H.B., and Carter, W.A.: Interferon action on parental Semliki Forest Virus RNA. J. Virol. 1:1168, 1967. 37. Baron, S., Buckler, C.E., Levy, H.B., and Friedman, R.M.: Some factors affecting the interferon induced antiviral state. Proc. Soc. Exp. Biol. Med. 125:1320, 1967. 38. Guggenheim, M.A., Friedman, R.M., and Rabson, A.S.: Interferon production in chick erythrocytes activated by cell fusion. Science 159:542-543, 1968. 39. Friedman, R.M.: Interferon and virus infections. Am. J. Nursing 68:542-546, 1968. 6 40. Friedman, R.M., and Pastan, I.: Specific inhibition of virus growth by phospholipase C. Proc. Nat. Acad. Sci. 59:1371-1378, 1968. 41. Pastan, I., and Friedman, R.M.: Inhibition of cell phospholipid synthesis by actinomycin D. Science 160:316-317, 1968. 42. Friedman, R.M.: Replicative intermediate on an arbovirus. J. Virol. 2:547-552, 1968. 43 Friedman, R.M.: Protein synthesis directed by an arbovirus. J. Virol. 2:26-32, 1968. 44. Friedman, R.M.: Effect of elevated incubation temperature on non-structural arbovirus proteins. Biochem. Biophys. Res. Comm. 32:1002-1005, 1968. 45. Friedman, R.M.: Structural and non-structural arbovirus proteins. J. Virol. 2:1076-1081, 1968. 46. Friedman, R.M.: Interferon inhibition of arbovirus protein synthesis. J. Virol. 2:1081-1085, 1968. 47. Grimley, P.M., Berezesky, I.K., and Friedman, R.M.: Cytoplasmic structures associated with arbovirus infection: Loci of viral RNA synthesis. J. Virol. 2:1326-1338, 1968. 48. Friedman, R.M., and Pastan, I.: Nature and function of the phospholipids of an arbovirus. J. Mol. Biol. 40:107, 1969. 49. Guggenheim, M.A., Friedman, R.M., and Rabson, A.S.: Interferon action in heterokaryons. Proc. Soc. Exp. Biol. Med. 130:1242-1245, 1969. 50. Friedman, R.M., and Grimley, P.M.: Inhibition of arbovirus assembly by cycloheximide. J. Virol. 292- 299, 1969. 51. Stern, R., and Friedman, R.M.: Separation of arbovirus RNA forms on a BD cellulose column. J. Virol. 356, 1969. 52. Friedman, R.M., and Pastan, I.: Interferon and cyclic-3'5'-AMP: Potentiation of antiviral action. Biochem. Biophys. Res. Comm. 36:735-740, 1969. 53. Friedman, R.M.: Primary gene products of an arbovirus. Biochem. Biophys. Res. Comm. 37:369-373, 1969. 54. Grimley, P.M., and Friedman, R.M.: Development of Semliki Forest Virus in mouse brain: An electron microscopic study. J. Exp. Mol. Path. 12:1-13, 1970. 55. Friedman, R.M., and Sonnabend, J.A.: Mechanism of action of interferon. Arch. Int. Med. 126:51-63, 1970. 7 56. Stern, R., and Friedman, R.M.: Apparent double-stranded RNA synthesized in animal cells in the presence of actinomycin D. Nature 226:612-616, 1970. 57. Barth, R.F., Friedman, R.M., and Malmgren, R.A.: Depression of interferon production in mice after treatment with antilymphocyte serum. Lancet 2:723-724, 1969. 58. Friedman, R.M., and Pastan, I.: Mechanism of action of MPB: a reversible inhibitor of interferon action. Proc. Nat. Acad. Sci. U.S.A. 65:104-109, 1970. 59. Friedman, R.M.: Interferon inhibition of protein synthesis directed by the genome of parental Semliki Forest Virus. Proc. of the Joint Japan-American Conference on Interferon, 1969. In Nagano, Y., and Levy, H.B. (Eds.): Interferon, Igaku Shoin Ltd., Tokyo, 1970, pp. 44-57. 60. Friedman, R.M., and Sonnabend, J.A.: Factors which modify interferon assay in chick cells. Internat. Symp. on Standardization of Interferon and Interferon Inducers, London, 1969; Symp. Series Immunobiol. Standard. 14:125-130, 1970. 61. Friedman, R.M.: Studies on the mechanism of interferon action. J. Gen. Physiol. 56:149-171, 1970. (Special Supplement) 62. Friedman, R.M.: Studies on the mechanism of interferon action. Proc. of the New York Heart Assoc. Symp. on Interferon, 1969. In Vilcek, J. (Ed.): Interferon. Little, Brown, New York, 1970, pp. 149- 171. 63. Grimley, P.M., and Friedman, R.M.: Arboviral infection of voluntary striated muscles. J. Infect. Dis. 122:45-52, 1970. 64. Friedman, R.M., and Sreevalsan, T.: Membrane binding of input arbovirus ribonucleic acid: Effect of interferon or cycloheximide. J. Virol. 6:169-175, 1970. 65. Friedman, R.M.: Interferon inhibition of protein synthesis directed by the genome of input Semliki Forest virus. In L'Interferon. Publication No. 6; Colloques de L'Institut National de La Sante' et de La Recherche Me' dicale; Minister of Public Health and Social Security, 1970, pp. 101-118. 66. Friedman, R.M., Guggenheim, M.A., and Rabson, A.S.: Interferon action in heterokaryons. In L'Interferon. Publication No. 6; Colloques de L'Institute National de La Sante' et de La Recherche Me' dicale; Minister of Public Health and Social Security, 1970, pp. 153-158. 67. Friedman, R.M., and Pastan, I.: Potentiation of interferon's antiviral activity by cyclic-3.5.-adenosine monophosphate. In L'Interferon. Publication No. 6; Colloques de L'Institut National de La Sante' et de La Recherche Me' dicale; Minister of Public Health and Social Security, 1970, pp. 213-218. 68. Friedman, R.M.: Basis for variable response of arboviruses to guanidine treatment. J. Virol. 6:628-636, 8 1970. 69. Johnson, G.S., Friedman, R.M., and Pastan, I.: Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3'5'-cyclic monophosphate and its derivatives. Proc. Nat. Acad. Sci. 68: 425-429, 1971. 70. Johnson, G.S., Friedman, R.M., and Pastan, I.: Cyclic AMP-treated sarcoma cells acquire several morphological characteristics of normal fibroblasts. Ann. NY Acad. Sci. 185:413-416, 1971. 71. Levin, J.G., and Friedman, R.M.: Analysis of arbovirus ribonucleic acid forms by polyacrylamide gel electrophoresis. J. Virol. 7:504-514, 1971. 72. Friedman, R.M.: Antiviral agents. Maryland State Med. J. 20:70-75, 1971. 73. Friedman, R.M., Barth, R.F., and Stern, R.: Anomalous effects of heterologous serum on interferon production in mice. Nature 230:17-18, 1971. 74. Johnson, G.S., Friedman, R.M., and Pastan, I.: Analysis of the fusion of XC cells induced by homogenates of murine leukemia virus-infected cells and by purified murine leukemia virus. J. Virol. 7: 753-758, 1971. 75. Friedman, R.M., and Nebert, D.W.: Viral interference: The mechanism of action of interferon. In Mihich, E. (Ed.): Drugs and Cell Regulation, Academic Press, Inc., New York, 1971, pp. 309-329. 76. Myers, M., and Friedman, R.M.: Potentiation of human interferon production by superinduction. J. Nat. Cancer Inst. 47:757-764, 1971. 77. Stern, R., and Friedman, R.M.: Ribonucleic acid synthesis in the presence of actinomycin. Biochemistry 10:3635-3645, 1971. 78. Horvath, A.E., and Friedman, R.M.: Nucleic acid and proteins isolated from a strain of murine sarcoma virus (MSV-O). Introduced by A.S. Rabson. Proc. Soc. Exp. Biol. Med. 137:1075-1081, 1971. 79. Grimley, P.M., Levin, J.G., Berezesky, I.K., and Friedman, R.M.: Biologic activity associated with unique membranous structures formed during the replication of group A arboviruses. In Melnick, J.L. (Ed.): International Virology 2. Basel, S. Karger, 1972, p. 163. 80. Grimley, P.M., Levin, J.G., Berezesky, I.K., and Friedman, R.M.: Specific membranous structures associated with the replication of group A arboviruses. J. Virol. 10:492-503, 1972. 81. Friedman, R.M., Levin, J.G., Grimley, P.M., and Berezesky, I.K.: Membrane-associated replication complex in arbovirus infection. J. Virol. 10:504-515, 1972. 9 82. Friedman, R.M., Esteban, R.M., Metz, D.H., Tovell, D.R., Kerr, I.M., and Williamson, R.: Translation of RNA by L cell extracts: Effect of interferon. FEBS Letters 24:273-277, 1972. 83. Friedman, R.M., and Buckler, C.E.: Virus-induced interferons. In Bauer, D.J. (Ed.): Chemotherapy of Virus Diseases. Oxford, Pergamon Press, 1972, Vol. 1, pp. 365-404. 84. Friedman, R.M., Metz, D.H., Esteban, R.M., Tovell, D.R., Ball, L.A., and Kerr, I.M.: Mechanism of interferon action: Inhibition of viral messenger ribonucleic acid translation in L-cell extracts. J. Virol. 10:1184-1198, 1972. 85. Nebert, D.W., and Friedman, R.M.: Stimulation of aryl hydrocarbon hydroxylase induction in cell cultures by interferon. J. Virol. 11:193-197, 1973. 86. Sonnabend, J.A., and Friedman, R.M.: Mechanism of interferon action. In Finter, N.B. (Ed.): Interferons and Interferon Inducers. Amsterdam-London, North-Holland Publ. Co. Inc., 1973, pp. 201- 239. 87. Kerr, I.M., Friedman, R.M., Esteban, R.M., Brown, R.E., Ball, L.A., Metz, D.H., Risby, D., Tovell, D.R., and Sonnabend, J.A.: The control of protein synthesis in interferon-treated cells. In Raspe, E. (Ed.): Advances in the Biosciences. Vieweg, Pergamon Press, 1973, Vol. 11, pp. 109-126. 88. Kerr, I.M., Friedman, R.M., Brown, R.E., Ball, L.A., and Brown, J.C.: The inhibition of protein synthesis in cell-free systems from interferon-treated, infected cells: further characterization and effect of formylmethionyl-tRNAf. J. Virol. 13:9-21, 1974. 89. Stern, R, Rose, J.A., and Friedman, R.M.: Phleomycin-induced cleavage of deoxyribonucleic acid. Biochemistry 13:307-312, 1974. 90. Friedman, R.M.: Interferon research in the Red Queen's Kingdom. Archives of Pathology 98:73-75, 1974. 91. Friedman, R.M., Stern, R., and Rose, J.A.: Phleomycin stimulation of thymidine triphosphate incorporation by animal cell nuclei. J. Nat. Cancer Inst. 52:693-697, 1974. 92. Friedman, R.M., and Ramseur, J.M.: Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon. Proc. Natl. Acad. Sci. U.S.A. 71:3542-3544, 1974. 93. Friedman, R.M.: The inhibition of protein synthesis in cell-free systems from interferon-treated, infected cells. In Geraldes, A. (Ed.): Effects of Interferon in Cells, Viruses, and the Immune System. Academic Press, London, 1975, pp. 553-573. 94. Friedman, R.M., Chang, E.H., Ramseur, J.M., and Myers, M.W.: Interferon-directed inhibition of 10 chronic murine leukemia virus production in cell cultures: lack of effect on intracellular viral markers. J. Virol. 16:567-574, 1975. 95. Friedman, R.M., and Costa, J.R.: Fate of interferon-treated cells. Infection and Immunity 13:487-493, 1976. 96. Friedman, R.M., Costa, J.C., Ramseur, J.M., Myers, M.W., Jay, F.T., and Chang, E.H.: Persistence of the viral genome in interferon-treated cells infected with oncogenic or nononcogenic viruses. The Journal of Infectious Diseases 133:A43-A50, 1976. 97. Friedman, R.M., and Kohn, L.D.: Cholera toxin inhibits interferon action. Biochem. Biophys. Res. Commun. 70:1078-1083, 1976. 98. Kohn, L.D., Friedman, R.M., Holmes, J.M., and Lee, G.: Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initieates its antiviral activity. Proc. Nat. Acad. Sci., USA 73:3695- 3699, 1976. 99. Ramseur, J.M., and Friedman, R.M.: Interferon Inhibits Induction of Endogenous Murine Leukemia Virus Production. Virology 73:553-556, 1976. 100. Friedman, R.M., Jay, F.T., Chang, E.H., Myers, M.W., Ramseur, J.M., Mims, S.J., Triche, T.J., Wong, P.K.Y.: Interferon-Directed Inhbition of Chronic Murine Leukemia Virus Production in Cell Cultures. In Chirigos, M.A. (Ed.): Control of Neoplasia by Modulation of the Immune System. Raven Press, New York, 1977, pp. 347-359. 101. Wong, P.K.Y., Yuen, P.H., Macleod, R., Chang, E.H., Myers, M.W., and Friedman, R.M.: The Effect of Interferon on de novo Infection of Moloney Murine Leukemia Virus. Cell 10:245-252, 1977. 102. Chang, E.H., Myers, M.W., Wong, P.K.Y., and Friedman, R.M.: The inhibitory effect of interferon on a temperature-sensitive mutant of Moloney murine leukemia virus. Virology 77:625-636, 1977. 103. Chang, E.H., and Friedman, R.M.: A large glycoprotein of Moloney leukemia virus derived from interferon-treated cells. Biochem. Biophys. Res. Commun. 77:392-398, 1977. 104. Chang, E.H., Mims, S.J., Triche, T.J., and Friedman, R.M.: Interferon inhibits mouse leukemia virus release: an electron microscope study. J. Gen. Virol. 34:363-367, 1977. 105. Jay, G., Jay, F.T., Friedman, R.M., and Levine, A.S.: Simian Virus 40-specific ribosome-binding proteins induced by a nondefective adenovirus 2-Simian Virus 40 hybrid. J. Virol. 23:692-699, 1977. 106. Strauchen, J.A., Young, N.A., and Friedman, R.M.: Interferon-mediated inhibition of mouse mammary tumor virus expression in cultured cells. Virology 82:232-236, 1977. 107. Friedman, R.M.: Antiviral activity of interferons. Bact. Rev. 41:543-567, 1977. 11 108. Meldoleshi, M.F., Friedman, R.M., and Kohn, L.D.: An interferon-induced increase in cyclic AMP levels precedes the establishment of the antiviral state. Biochem. Biophys. Res. Commun. 79:239-246, 1977. 109. Ramseur, J.M., and Friedman, R.M.: Prolonged infection of interferon-treated cells by Vesicudlar Stomatitis Virus: Possible role of temperature-sensitive mutants and interferon. J. Gen. Virol. 37:523- 533, 1977. 110. Friedman, R.M., and Chang, E.H.: Interferon action: Possible mechanisms of antiviral activity. In Stewart III, W.E. (Ed.): Interferons and Their Actions. CRC Press, 1977, pp. 145-152. 111. Friedman, R.M.: Interferon action and the cell surface. Pharmac. Ther. A, 2:425-438, 1978. 112. Chang, E.H., Jay, F.T., and Friedman, R.M.: Physical morphological, and biochemical alterations in the membrane of AKR mouse cells after interferon treatment. Proc. Nat'l. Acad. Sci. USA 75:1859-1863, 1978. 113. Jay, G., Jay, F.T., Friedman, R.M., and Levine, A.S.: Biosynthesis, immunological specificity, and intracellular distribution of the simian virus 40-specific protein induced by the nondefective hybrid + Ad2 ND1. J. Virol. 26:411-419, 1977. 114. Kohn, L.D., Lee, G., Grollman, E.F., Ledley, F.D., Mullin, B.R., Friedman, R.M., Meldolesei, M.F., and Aloj, S.M.: Membrane glycolipids and their relationship to the structure and function of cell surface receptors for glycoprotein hormones, bacterial toxins, and interferon. In Cell Surface Carbohydrate Chemistry, Academic Press, New York, 1978, pp. 303-333. 115. Friedman, R.M.: Interferons and Cancer. J. Nat'l. Cancer Inst. 60:1191-1194, 1978. 116. Ramseur, J., and Friedman, R.M.: Prolonged infection of L cells with vesicular stomatitis virus. Virology 85:253-261, 1978. 117. Friedman, R.M., Grollman, E.F., Chang, E.H., Kohn, L.D., Lee, G., and Jay, F.T.: Interferon and glycoprotein hormones. In The Interferon System, University of Texas Medical Branch, Texas, 1978, pp. 326-329. 118. Jay, G., Jay, F.T., Chang, D., Friedman, R., and Levin, A.S.: Tumor-specific transplantation antigen: + Use of the Ad2 ND1 hybrid virus to identify the protein responsible for simian virus 40 tumor rejection and its genetic origin. Proc. Nat'l. Acad. Sci. USA 75:3055-3059, 1978. 119. Friedman, R.M.: The mechanism of action of interferon: possible primary effects on membranes. Horizons in Biochem. and Biophys. 5:281-313, 1978. 12 120. Friedman, R.M.: Interferon and cancer treatment. Ca - a Cancer Journal for Clinicians 28:278-283, 1978. 121. Grollman, E.F., Lees, G., Ramos, S., Lazo, P.S., Kaback, H.R., Friedman, R.M., and Kohn L.D.: Relationships of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state. Cancer Research 38:4172-4185, 1978. 122. Chang, E.H., Grollman, E.F., Jay, F.T., Lee, G., Kohn, L.D. and Friedman, R.M.: Membrane Alterations Following Interferon Treatment. Human Interferon 85-99, 1978. 123. Torrence, P.F. and Friedman, R.M.: Are double-stranded RNA-directed inhibition of protein synthesis in interferon-treated cells and interferon induction related phenomena? J. Biol. Chem. 254:1259-1267, 1979. 124. Friedman, R.M.: Induction and production of interferon in Methods in Enzymology Vol LVIII Cell Culture (William B. Jakoby and Ira H. Pastan) pp 292-296, Academic Press, New York, 1979. 125. Bandyopadhyay, A.K., Chang, E.H., Levy, C.C., and Friedman, R.M.: Structural abnormalities in murine leukemia viruses produced by interferon-treated cells. Biochem. Biophys. Res. Comm. 87:983- 988, 1979. 126. Friedman, R.M., and Ramseur J.M.: Mechanisms of persistent infections by cytopathic viruses in tissue culture. Brief Review. Arch. Virol. 60:83-103, 1979. 127. Jay, G., Jay, F.T., Chang, C., Levine, A.S., and Friedman, R.M.: Induction of simina virus 40-specific + tumour rejection by the Ad2 ND2 hybrid virus. J. Gen. Virol. 44:287-296, 1979. 128. Maheshwari, R.K., and Friedman, R.M.: Production of vesicular stomatitis virus with low infectivity by interferon-treated cells. J. Gen. Virol. 44:261-264, 1979. 129. Maheshwari, R.K., Jay, F.T., and Friedman, R.M.: Selective inhibition of glycoprotein and membrane protein of vesicular stomatitis from interferon-treated cells. Science 207:540-541, 1980. 130. Espstein, D.A., Torrence, P.F., and Friedman, R.M.: Double-stranded RNA inhibits a phosphoprotein phosphatase present in interferon-treated cells. Proc. Natl. Acad. Sci., USA 77:107-111, 1980. 131. Friedman, R.M.: Interferons: Interactions with cell surfaces. Interferon 1:55-74, 1979. 132. Maheshwari, R.K., and Friedman, R.M.: Effect of interferon treatment on vesicular stomatitis virus (VSV): Release of unusual particles with low infectivity. Virology 101:399-407, 1980. 133. Maheshwari, R.K., Demsey, A.E., Mohanty, S.B., and Friedman, R.M.: Interferon-treated cells release vesicular stomatitis virus particles lacking glycoprotein spikes: Correlation with biochemical data. Proc. Natl. Acad. Sci. USA 77:2284-2287, 1980. 13 134. Berger, S.L., Hitchcook, J.M., Zoon, K.C., Birkenmeier, C.S., Friedman, R.M., and Chang, E.H.: Characterization of interferon messenger RNA synthesis in namalva cells. J. Biol. Chem. 255:2955- 2961, 1980. 135. Friedman, R.M.: Interferon-mediated inhibition of murine leukemia virus replication. Microbiology pp 214-216, 1980. 136. Friedman, R.M.: Interferons in host resistance. Microbiology pp. 125-127, 1980. 137. Maheshwari, R.K., Lazo, P.S., Friedman, R.M., and Kohn, L.D.: Enhancement of interferon activity by a membrane glycoprotein related to the thyrotropin receptor. In Interferon: Properties and Clinical Uses. (Eds.) Khan, A., Hill, N.O., Dorn, G.L. Wadley Institutes of Molecular Medicine, Dallas, Texas, 1980, pp. 387-396. 138. Maheshwari, R.K., Banerjee, D.K., Waechter, C.J., Olden, K., and Friedman, R.M.: Interferon treatment inhibits glycosylation of a viral protein. Nature 287:454-456, 1980. 139. Maheshwari, R.K., and Friedman, R.M.: Morphological and biochemical characterization of vesicular stomatitis virus with low infectivity released from interferon treated cells. U.P. State Dental Journal (India), 11:95-110, 1980. 140. Torrence, P., Friedman, R.M., Kirk, K.L., Cohen, L.A., and Creveling, C.R.: 2-Fluorohistidine: Effects on protein synthesis in cell free systems and mouse L cells. Biochem. Pharmacol. 28:1565-1567, 1979. 141. Johnston, M.I., Friedman, R.M., and Torrence, P.F.: 2'5'-Oligoadenylate synthetase: A new assay and preliminary structure-activity relationships for enzyme activation by nucleic acids. Ann. of the N.Y. Academy of Sci., 350:603-604, 1980. 142. Johnston, M.I., Zoon, K.C., Friedman, R.M., De Clercq, E., and Torrence, P.F.: Oligo(2'-5')Adenylate synthetase in human lymphoblastroid cells. Biochemical and Biophy. Res. Comm. 97:375-383, 1980. 143. Johnston, M.I., Friedman, R.M., and Torrence, P.F.: Interferon-induced (2'-5') Oligoadenylate synthetase: Adsorption to and assay on adenosine 2',5'-diphosphate-sepharose. Biochemistry 19:5580- 5585, 1980. 144. Maheshwari, R.K., Banerjee, D.K., Waechter, C.J., Olden, K., and Friedman, R.M.: Interferon treatment inhibits glycosylation of a viral protein. Nature 287:454-456, 1980. 145. Maheshwari, R.K., Jay, F.T., and Friedman, R.M.: Selective inhibition of glycoprotein and membrane protein content of vesicular stomatitis virus released by interferon-treated cells. Annals of N.Y. Acad. Sci. 330:601-602, 1980. 146. Epstein, D., Torrence, P.F., and Friedman, R.M.: Inhibition by double-stranded RNA of a phosphoprotein phosphatase present in interferon-treated cells. Annals of N.Y. Acad. Sci. 350:605-606, 1980. 14 147. Hitchcock, M.J.M., and Friedman, R.M.: Microinjection of Xenopus oocytes: An automated device for volume control in the nanoliter range. Analytical Biochem. 109:338-344, 1980. 148. Czarniecki, C.W., Sreevalsan, T., Friedman, R.M., and Panet, A.: Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells. J. Virol. 37:827-831, 1981. 149. Arya, S.K., Czarniecki, C.W., and Friedman, R.M.: Interferon induced inhibition of mouse mammary tumor virus production. J. Interferon Res. 1:147-154, 1980. 150. Friedman, R.M., Maheshwari, R.K., Jay, F.T., and Czarniecki, C.: Mechanism of interferon inhibition of viruses that bud from the plasma membrane. Ann. N.Y. Acad. Sci. 350:533-544, 1980. 151. Epstein, D.A., Czarniecki, C.W., Jacobsen, H., Friedman, R.M., and Panet, A.: A mouse cell line, which is unprotected by interferon against lytic virus infection, lacks ribonuclease F activity. Eur. J. Biochem. 118:9-15, 1981. 152. Torrence, P.F., Johnston, M.I., Epstein, D.A., Jacobsen, H., and Friedman, R.M.: Activation of human and mouse 2-5A synthetases and mouse protein P1 kinase by nucleic acids. FEBS Letters 130:291-296, 1981. 153. Friedman, R.M.: Interferons, a primer. Academic Press, 1981, 185 pp. (book) 154. Friedman, R.M.: Interferons. In Cellular Functions in Immunity and Inflammation. (Eds.) Oppenheim, J.J., Rosenstreich, D.L., and Potter, M. Elsevier/North-Holland. New York/Amsterdam, pp. 283-299, 1981. 155. Friedman, R.M., Kohn, K.D., Lee, G., Epstein, D., and Jacobsen, H.: Stimulatory activity by mouse interferon on the uptake of iodide by rat thyroid cells. In De Maeyer, E., Galasso, G., and Schellekens, H. (eds.). The Biology of the Interferon System. Elsevier/North Holland Biomedical Press, 1981. 156. Panet, A., Czarniecki, C.W., Falk, H., and Friedman, R.M.: Effect of 2'5'-Oligoadenylic acid on a mouse cell line partially resistant to interferon. Virology 114:567-572, 1981. 157. Maheshwari, R.K., Lad, P.M., and Friedman, R.M.: Assays and procedures to study changes in cellular cAMP concentrations after interferon treatment of cells. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 162-168, Academic Press, New York, 1981. 158. Epstein, D.A., Torrence, P.E., and Friedman, R.M.: Measurement of inhibition of phosphoprotein phosphatase activity by Poly(I).Poly(C) in extracts of interferon-treated cells. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 179-184, Academic Press, New York, 1981. 159. Johnston, M.I., Friedman, R.M., and Torrence, P.E.: Assay of (2'-5')-Oligo(a) synthetase with 2',5'-ADP separose. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 228-233, Academic 15 Press, New York, 1981. 160. Maheshwari, R.K., Vijay, I.K., Olden, K., and Friedman, R.M.: Assay of glycosyltransferase activities in microsomal preparation from cells treated with interferon. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 302-306, Academic Press, New York, 1981. 161. Sreevalson, T., Lee, E., and Friedman, R.M.: Assay of effect of interferon on intracellular enzymes. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 342-349, Academic Press, New York, 1981. 162. Maheshwari, R.K., and Friedman, R.M.: Assay of effect of interferon on viruses that bud from plasma membrane. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 451-458, Academic Press, New York, 1981. 163. Friedman, R.M.: Cell surface alterations induced by interferon. In Methods in Enzymology Vol. 79 Interferons Part B (S. Pestka, ed.) pp 458-461, Academic Press, New York, 1981. 164. Jacobson, S., Friedman, R.M., and Pfau, C.J.: Interferon induction by lymphocytic choriomeningitis viruses correlates with maximum virulence. J. Gen. Virol. 57:275-283, 1981. 165. Friedman, R.M.: Interferon: Interferon and Interferon Inducers. Science 209:326-327, 1981 (Book Review). 166. Friedman, R.M., Epstein, L.B., and Merigan, T.C.: Interferon redux. Nature 296:704-705, 1982. 167. Preble, O.T., Black, R.J., Friedman, R.M., Klippel, J.H., and Vilcek, J: Systemic lupus erythematosus: Presence in human serum of an unusual acid-labile leukocyte interferon. Science 216:429-431, 1982. 168. Harrell, S.A., Maheshwari, R.K., Mohanty, S.B., Friedman, R.M.: Effect of human interferon on vesicular stomatitis virus released from bovine embryonic kidney cells. Am. J. Vet. Res. 43:565-568, 1982. 169. Friedman, R.M.: Interferons: Basic Research, Clinical Studies, and Their Support. Arch. Pathol. Lab. Med. 106:259-260, 1982. 170. Czarniecki, C.W., and Friedman, R.M.: Antitumor Activities of Interferons. Molec. Aspects Med. 5:209-224, 1982. 171. Friedman, R.M., Lee, G., Shifrin, S., Ambesi-Impiombato, S., Epstein, D., Jacobsen, H., and Kohn, L.: Interferon Interactions with Thyroid Cells. J. IFN Res. 2(3):387-400, 1982. 172. Torrence, P.F., Imai, J., Lesiak, K., Johnston, M.I., Jacobsen, H., Friedman, R.M., Sawai, H., and Safer, B.: Double-Stranded RNA and 2',5'-Oligoadenylates: Companions in Interferon Action? In Interferons Vol. XXV (T.C. Merigan and R.M. Friedman, eds.) pp 143-157, Academic Press, New York, 1982. 16 173. Turek, L.P., Byrne, J.C., Lowy, D.R., Dvoretzky, I., Friedman, R.M., and Howley, P.M.: Interferon Inhibits Bovine Papillomavirus Transformation of Mouse Cells and Induces Reversion of Established Transformants. In Interferons Vol. XXV (T.C. Merigan and R.M. Friedman, eds.) pp 181-191, Academic Press, New York, 1982. 174. Preble, O.T., Black, R.J., Klippel, J.H., Friedman, R.M., and Vilcek, J.: Interferon in Systemic Lupus Erythematosus. In Interferons Vol. XXV (T.C. Merigan and R.M. Friedman, eds.) pp 219-231, Academic Press, New York, 1982. 175. Friedman, R.M.: Effects of Interferons on Cell Membranes. In The Interferon System: A Review to 1982 - Part I Vol. 41 (S. Baron, F. Dianzani, and G.J. Stanton, eds.) pp 313-316, The University of Texas Medical Branch, Galveston, 1982. 176. Friedman, R.M., Czarniecki, C.W., Epstein, D.A., Jay, F.T., Maheshwari, R.K., Sreevalsan, T., and Panet, A.: Mechanisms of Interferon Action on Cell Growth and on Murine Leukemia, Vesicular Stomatitis, and Encephalomyocarditis Viruses. In Interferon: Properties, Mode of Action, Productions, Clinical Applications Vol. 11 (K. Munk and H. Kirchner, eds.) pp 1-10, S. Karger, Basel (Switzerland), 1982. 177. Friedman, R.M., Preble, O., Black, R., and Harrell, S.: Interferon Production in Patients with Systemic Lupus Erythematosus. Arth. Rheum. 25(7):802-803, 1982. 178. DeStefano, E., Friedman, R.M., Friedman-Kien, A.E., Goedert, J.J., Henriksen, D., Preble, O.T., Sonnabend, J.A., and Vilcek, J.: Acid-Labile Human Leukocyte Interferon in Homosexual Men with Kaposi's Sarcoma and Lymphadenopathy. J. Inf. Dis. 146(4):451-455, 1982. 179. Turek, L.P., Byrne, J.C., Lowry, D.R., Dvoretzky, I., Friedman, R.M., and Howley, P.M.: Interferon induces morphologic reversion with elimination of extrachromosomal viral genomes in bovine papillomavirus-transformed mouse cells. Proc. Natl. Acad. Sci. USA 79:7914-7918, 1982. 180. Jacobsen, H., Epstein, D.A., Friedman, R.M., Safer, B., and Torrence, P.F.: Double-stranded RNA- dependent phosphorylation of protein P1 and eukaryotic initiation factor 2 does not correlate with protein synthesis inhibition in a cell-free system from interferon-treated mouse L cells. Proc. Natl. Acad. Sci. USA 80:41-45, 1983. 181. Demsey, A. and Friedman, R.M. Reexamination of the morphogenetic block of a putative late-stage, temperature-sensitive mutant of Moloney mouse leukemia virus. J. Virol. 45(3):1140-1142, 1983. 182. Maheshwari, R.K., Sreevalsan, T., Silverman, R.H., Hay, J., and Friedman, R.M. Tunicamycin enhances the antiviral and anticellular activity of interferon. Science 219:1339-1341, 1983. 183. Jacobsen, H., Czarniecki, C.W., Krause, D., Friedman, R.M., and Silverman, R.H.: Interferon-induced synthesis of 2-5A-dependent RNase in mouse JLS-V9R Cells. Virology 125:496-501, 1983. 184. Jay, F.T., Dawood, M.R., and Friedman, R.M.: Interferon induces the production of membrane protein- 17 deficient and infectivity-defective vesicular stomatitis virions through interference in the virion assembly process. J. Gen. Virol. 64:707-712, 1983. 185. Maheshwari, R.K., Husain, M.M., Attallah, A.M., and Friedman, R.M.: Tunicamycin treatment inhibits the antiviral activity of interferon in mice. Infect. Immun. 41(1):61-66, 1983. 186. Preble, O.P., and Friedman, R.M.: Biology of Disease. Interferon-induced alterations in cells: Relevance to viral and nonviral disease. Lab. Invest. 49:4-19, 1983. 187. Preble, O.T., Rothko, K., Klippel, J.H., Friedman, R.M., and Johnston, M.I.: Interferon-induced 2'-5' adenylate synthetase in vivo and interferon production in vitro by lymphocytes from SLE patients with and without circulating interferon. J. Exp. Med. 157:2140, 1983. 188. Maheshwari, R.K., Husain, M.M., Serrate, S., Attallah, A.M., and Friedman, R.M.: The in vivo and in vitro antiviral effect(s) of interferons may be mediated through different mechanism(s). In The Biology of the Interferon System 1983 (E. De Maeyer and H. Schellekens, eds.) pp 257-263, Elsevier Science Publishers B.V., 1983. 189. Silverman, R.H., Krause, D., Jacobsen, H., Leisy, S.A., Barlow, D.P., and Friedman, R.M.: 2-5A- dependent RNase levels vary with interferon-treatment, growth rate and cell differentiation. In The Biology of the Interferon System 1983 (E. De Maeyer and H. Schellekens, eds.) pp 189-200, Elsevier Science Publishers B.V., 1983. 190. Preble, O.T. and Friedman, R.M.: Characterization of acid-labile alpha interferon from patients with autoimmune diseases. InThe Biology of the Interferon System 1983 (E. De Maeyer and H. Schellekens, eds.) pp 379-386, Elsevier Science Publishers B.V., 1983. 191. Samid, D., Chang, E.H., and Friedman, R.M.: Revertants from interferon-treated mouse cells transformed by a human oncogene. In The Biology of the Interferon System 1983 (E. De Maeyer and H. Schellekens, eds.) pp 359-360, Elsevier Science Publishers B.V., 1983. 192. Jacobsen, H., Krause, D., Friedman, R.M., and Silverman, R.H.: Induction of ppp(A2'p)nA-dependent RNase in murine JLS-V9R cells during growth inhibition. Proc. Natl. Acad. Sci. USA 80:4954-4958, 1983. 193. Friedman, R.M.: Mechanisms of antiviral action of interferons. In Recent Advances in Haematology, Immunology and Blood Transfusion (S.R. Hollan et al., eds.) pp 313-324, Publishing House of the Hungarian Academy of Sciences, 1983. 194. Friedman, R.M. and Vogel, S.N.: Interferons with Special Emphasis on the Immune System. In Advances in Immunology Volume 34 (F.J. Dixon and H.G. Kunkel, eds.) pp. 97-140, Academic Press, 1983. 195. Maheshwari, R.K., Husain, M.M., and Friedman, R.M.: Low infectivity of vesicular stomatitis virus (VSV) particles released from interferon- treated cells is related to glycoprotein deficiency. Biochem. 18 Biophy. Res. Com. 117(1):161-168, 1983. 196. Grimley, P.M., Kang, Y-H., Masur, H., Frederick, W., Hoofnagle, J., Klippel, J., and Friedman, R.M.: Tubuloreticular inclusions in patients with AIDS: Interferon-related effect in circulating T-cells and monocytes. In The Epidemic of Kaposi's Sarcoma and Opportunistic Infections (A.E. Friedman-Kien and L.J. Laubenstein, eds.) pp. 181-192, New York: Masson Press, 1984. 197. Grimley, P.M., Kang, Y-H., Frederick, W., Rook, A.H., Kostianovsky, M., Sonnabend, J.A., Macher, A.M., Quinnan, G.V., Friedman, R.M., and Masur, H.: Interferon-related leukocyte inclusions in acquired immune deficiency syndrome: localization in T cells. J. Clin. Path. 81(2):147-155, 1984. 198. Samid, D., Chang, E.H., and Friedman, R.M.: Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene. Biochem. Biophy. Res. Com. 119(1):21-28, 1984. 199. Vilcek, J., Friedman-Kien, A.E., Henriksen-DeStefano, D., Sonnabend, J.A., Preble, O.T., and Friedman, R.M.: The role of interferon in AIDS. In The Epidemic of Kaposi's Sarcoma and Opportunistic Infections (A.E. Friedman-Kien and L.J. Laubenstein, eds.) pp. 193-198, New York: Masson Press, 1984. 200. Friedman, R.M. Interferons and their applications (book review) Nature 311:183, 1984. 201. Samid, D., Chang, E.H., and Friedman, R.M.: Development of transformed phenotype induced by a human ras oncogene is inhibited by interferon. Biochem. Biophy. Res. Com. 126(1):509-516, 1985. 202. Friedman, Robert M.: Editor Interferon vol.3 Mechanisms of production and action. General editor. N.B. Finter Elsevier, Amsterdam, 1984, 396. 203. Friedman, Robert M. and Pitha, Paula M. THe effect of interferon on membrane - associated viruses in Interferons vol 3. Mechanisms of production of action (R.M. Friedman, ed.) Elsevier, Amsterdam 1984. pp. 319-341. 204. Krause, D., Silverman, Robert H., Jacobsen, H., Leisy, Sharon A., Dieffenbach, Carl W., and Friedman, Robert M. Regulation of ppp(A2'p)nA-dependent RNase levels during interferon treatment and cell differentiation. Eur. J. Biochem. 146, pp 611-618, 1985. 205. Preble, O.T., A.H. Rook, G.V. Quinnan, J.Vilcek, R.M. Friedman, R. Steis, E.P. Gelmann and J.A. Sonnabend. Role of Interferon in AIDS. Annals of the New York Acad. Sci, 437:65-75, 1985. 206. Preble, O.T., J. Vilcek, A.E. Friedman Kien, R.M. Friedman, J.J. Goedert and J.A. Sonnabend. Acid- labile leukocyte interferon in homosexual men with Kaposi's sarcoma and lymphadenopathy. In The Acquired Immuno-deficiency Syndrome and Infections of Homosexual Men, ed. by P. Ma and D. Armstrong, Yorke, 1983, p. 381. 207. Friedman, R.M., The Interferon Crusade. (Book Review), J. Hist. Med.,40:377-380, 1985. 19 208. Friedman, R.M., Antiviral Chemotherapy, Interferons and Vaccines. (Book Review), The Quarterly Review of Biology, 60:252, 1985. 209. Samid, D., Schaff, Z., Chang, E.H., and Friedman, R.M. Reduction in ras expression accompanies phenotypic reversion of interferon-treated, c-Ha-ras oncogene-transformed mouse cells in: The Biology of the Interferon System 1984 (Kirchner, H. and Shellekens, H., eds) Elsevier, Amsterdam. pp 189-198, 1985. 210. Samid, D., Schaff, Z., Chang, E.H., and Friedman, R.M. 1985 Interferon-induced modulation of human ras oncogene expression in: Endocoids. Progress in Clinical and Biological Research Vol. 192. (eds. Lal, H., La Bella, F., and Lane, J.) Alan R. Liss, New York. pp 265-268, 1985. 211. Samid, D., Chang, E.H., and Friedman, R.M. Specific inhibition by interferon of oncogene-induced transformation in Serono Symposia Publications vol 24 (eds Dianzani, F. and Rossi, G.B.) Raven Press, New York. pp 415-422, 1985. 212. Black, R. J., Friedman, R.M., Imai, J. and Torrence, P.F., Antogonism of 2-5A-mediated inhibition of protein synthesis in intact cells by 2',5'-(pA)3, FEBS Letters 191:154-158, 1985. 213. Vogel, S.N. and Friedman, R.M., Interferon and macrophages: activation and cell surface changes,In Interferon, Volume 2: Interferons and the Immune System, (J. Vilcek and E. De Maeyer, eds.), pp. 35- 59, Elsevier Science Publishers B.V., 1984. 214. Maheshwari, R.K., Husain, M.M., Friedman, R.M. and Krishna, G.: The calcium ionophore A23187 evokes and potentiates antiviral activity of interferon. J. Interferon Res. 5: 605-612, 1985. 215. Samid, D., Flessate, D.M., Greene, J.J., Chang, E.H., and Friedman, R.M. Mechanisms of Antioncogenic activity of interferon in The 2-5A System: molecular and clinical aspects of the interferon- regulated pathway (B.R.G. Williams and R.H. Silverman eds.) pp203-210 Alan R. Liss, N.Y., (vol 202 in Prigin Clinical and Biological Research), 1985. 216. Maheshwari, R.K. and Friedman, R.M. Interferon-induced inhibition of enveloped viruses in The 2-5A System: molecular and clinical aspects of the interferon-regulated pathway (B.R.G. Williams and R.H. Silverman eds.) pp297-306 Alan R. Liss, N.Y., (vol 202 in Prigin Clinical and Biological Research), 1985. 217. Singh, V.K., Maheshwari, R.K., Krishna, G., and Friedman, R.M. Effect of interferon on calcium in The 2-5A System: molecular and clinical aspects of the interferon-regulated pathway (B.R.G. Williams and R.H. Silverman eds.) pp351-356 Alan R. Liss, N.Y., (vol 202 in Prigin Clinical and Biological Research), 1985. 218. Samid, D., Chang, E.H., and Friedman, R.M.: Biological and morphological characteristics of phenotypic revertants appearing in interferon-treated mouse cells transformed by a human oncogene. J. Exper. Path. 2(3): 211-222, 1985. 20 219. Maheshwari, R.K., Singh, V.K., Husain, M.M. and Friedman, R.M.: Release of low infectivity vesicular stomatitis virus particles from tunicamycin-treated cells. J. Exper. Path. 2(3): 149-163, 1985. 220. Maheshwari, R.K., Czarneicki, C.W., Dutta, G.P., Puri, S.K., Dhawan, B.N., Friedman, R.M.: Recombinant Human Gamma Interferon Inhibits Simian Malaria. Infection and Immunity, 53:628-630, l986. 221. Friedman, R.M.: Growth factors and oncogenes. Modulation of growth and differentiation by interferons in Interferons in Cancer Treatment (ed.H.K.B. Silver) MES Medical Education Services, 1986 pp. 11-16. 222. Samid, D. and Friedman, R.M.: Transcriptional regulation of ras by interferon in Interferons as cell growth inhibitors and antitumor factors (eds R.M. Friedman, T. Merigan, and T. Sreevalsan) Alan R. Liss, New York, 1986, pp. 413-422. 223. Friedman, R.M. Growth factors, oncognes and Interferons. An Editorial J. Exp. Path. 2:223-229, l986. 224. Singh, V.J., Friedman, R.M., and Maheshwari, R.K. Tunicamycin inhibits natural killer cell and antiviral activity of interferonin mice in Interferons as cell growth inhibitors and antitumor factors (eds. R.M. Friedman, T. Merigan and T.Sreevalsan) Alan R. Liss, New York, l986, pp.209-222. 225. Friedman, R.M., Merigan, T., and Sreevalsan, T.(editors) Interferons as cell growth inhibitors and antitumor factors. Alan R. Liss, New York, l986. 226. Friedman, R.M. Antitumor activity by interferons in Interferons in Biomedical Research (eds Dhawan, B.N., Maheshwari, R.K., and Singh, N.B.), Central Drug Research Institute, Lucknow, India), pp. 54-73, l987. 227. Damewood, G.P., Singh, V.K., Friedman, R.M., and Maheshwari, R.K. The antiproliferative effects of interferon in Interferons in Biomedical Research (eds Dhawan, B.N., Maheshwari, R.K., and Singh, N.B.) CDRI, Lucknow (India), pp. 86-96, l987. 228. Panigraph, P., Mohanty, S.B., Maheshwari, R.K., and Friedman, R.M.: Structural Proteins of Bovine Parainfluenza-3 Virus. Vet. Microbiol., 13:205-210, 1987. 229. Singh, Vijay K., Damewood, George P. IV, Friedman, Robert M., and Maheshwari, Radha K.: Tunicamycin Enhances Virus Replication and Inhibits Antiviral Activity of Interferon in Mice: Correlation with Natural Killer Cells. J. of Exper. Path. 3:19-34, l987. 230. Samid, D., Flessate, D.M., and Friedman, R.M.: Interferon-Induced Revertants of ras-Transformed Cells: Resistance to Transformation by Specific Oncogenes and Retransformation by 5-Azacytidine. Molecular and Cellular Biology, 7(6):2196-2200, June 1987. 231. Friedman, R.M.: Antitumor Effects of Interferons. J. Exper. Path. 3(2):203-227, 1987. 232. Melloui, S., Maheshwari, R.K., Rhodes-Feuillette, A., Beaudoin, R.L., Berbiguier, N., Matile, H., 21 Miltgen, F., Landau, I., Sylvianne, Pied, Chigot, J.P., Friedman, R.M., and Mazier, D.: Inhibitory Activity of Interferons and Interleukin 1 on the Development of Plasmodium falciparum in Human Hepatocyte Cultures. J. of Immunology, 139(12):4192-4195, 1987. 233. Friedman, R.M.: The Discovery of Interferons as an Example of the Big Scientific Heist. J. of Interferon Research, 7:451-453, 1987. 234. Maheshwari, Radha K., Tandon, Rajesh N., Feuillette, Alice- Rhodes, Mahouy, G., Badillet, G., and Friedman, Robert M.: Interferon Inhibits Aspergillus fumigatus Growth in Mice: An Activity Against an Extracellular Infection. J. of Interferon Research, 8:35-44, 1988. 235. Panigrahi, P., Mohanty, S.B., Maheshwari, R.K., and Friedman, R.M.: Effect of Cloned Human Interferon-2a on Bovine Parainfluenza-3 Virus. Archives of Virology, 98:107-115, 1988. 236. Singh, V.K., Maheshwari, R.K., Damewood, G.P. IV., Stephensen, C.B., Oliver, C., and Friedman, R.M.: Interferon Alters Intracellular Transport of Vesicular Stomatitis Virus Glycoprotein. J. of Biological Regulators and Homeostatic Agents, Vol. 2 No. 2, pp. 53-62, 1988. 237. Rimoldi, Donata, Samid, Dvorit, Flessate, Denise, and Friedman, R.M.: Transcriptional Inhibition of Ha-ras in Interferon-induced Revertants of ras-transformed Mouse Cells. Cancer Research, 48:5157- 5162, 1988. 238. Szebeni, Janos, Wahl, Sharon M., Popovic, Mikulas, Wahl, Larry M., Gartner, Suzanne, Fine, Robert L., Skaleric, Uros, Friedman, R.M., and Weinstein, John N.: Dipyridamole Potentiates the Inhibition by 3'- Azido-3'-Deoxythymidine and other Dideoxynucleosides of Human Immunodeficiency Virus Replication in Monocyte-Macrophages. Proc. Natl. Acad. Sci., 86:3842-3846, 1989. 239. Friedman, R.M. and Oldham, R.K.: Antitumor Effects of Interferons in Cancer Growth and Progression. (Ed) P.V. Wooley, Kluwver Academy Publishers, Boston, MA., pp. 9-20, 1989. 239a. Reid, TR, Race, ER, Wolff, BH, Friedman, RM, Merigan, TC, Basham, TY: Enhanced in vivo therapeutic response in mice with an in vitro interferon-resistant B-cell lymphoma. Cancer Res. 49: 4163-4169, 1989. 240. Goedert, J.J., Kessler, C.M., Aledort, L.M., Biggar, R.J., Andes, W.A., White, G.C., Drummond, J.E., Vaidya, K., Mann, D.L., Eyster, M.E., Ragni, M.V., Lederman, M.M., Cohen, A.R., Bray, G.L., Rosenberg, P.S., Friedman, R.M., Hilgartner, M.W., Blattner, W.A., Kroner, B., and Gail, M.H.: A Prospective Study of Human Immunodeficiency Virus Type 1 Infection and the Development of AIDS in Subjects with Hemophilia. The New Eng. J. of Med., 321:1141-1148, 1989. 241. Black, R.J., and Friedman, R.M.: Cytokines and oncogene activity. Cancer Surveys 8(4):725-739, 1989. 242. Contente, S., Kenyon, K., Rimoldi, D., and Friedman, R.M.: Expression of Gene rrg is Associated with Reversion of NIH 3T3 Transformed by LTR-c-H-ras. Science, 249:796-798, 1990. 243. Gendelman, H.E., Baca, L.M., Turpin, J., Kalter, D.C., Hansen, B., Orenstein, J.M., Dieffenbach, C.W., 22 Friedman, R.M., and Meltzer, M.S.: Regulation of HIV replication in infected monocytes by IFN α. J. Immunol., 145:2669-2676, 1990. 244. Gendelman, H.E., Friedman, R.M., Joe, S., Baca, L.M., Turpin, J.A., Dveksler, G., Meltzer, M.S., and Dieffenbach, C.: A selective defect of interferon α production in human immunodeficiency virus infected monocytes. J. Exptl. Med., 172:1433-1442, 1990. 245. Gendelman, H.E., Baca, L., Turpin, J.A., Kalter, D.C., Hansen, B.D., Orenstein, J.M., Friedman, R.M., and Meltzer, M.S.: Restriction of HIV replication in infected T cells and monocytes by Interferon-α. AIDS Res. and Human Retroviruses, 6(8):1045-1049, 1990. 246. Rimoldi, D., Dieffenbach, C.W., Friedman, R.M., and Samid, D.: 2', 5'-Oligoadenylate synthetase gene expression in revertants of ras-transformed NIH3T3 fibroblasts. Exptl. Cell Res., 191:76-82, 1990. 247. Kenyon, K., Contente, S., Trackman, P.C., Tang, J., Kagan, H.M., and Friedman, R.M.: Lysyl oxidase and rrg messenger RNA. Science, 253:802, 1991. 248. Maheshwari, R.K., Sidhu, G.S., Bhartiya, D., and Friedman, R.M.: Primary amines enhance the antiviral activity of interferon against a membrane virus: role of intracellular pH. Journal of Gen. Virol., 72:2143-2152, 1991. 249. Szebeni, J., Dieffenbach, C.W., Wahl, S.M., Venkateshan, C.N., Yeh, A., Popovic, M., Gartner, S., Wahl, L.M., Peterfy, M., Friedman, R.M., and Weinstein, J.N.: Induction of Alpha Interferon by Human Immunodeficiency Virus Type 1 in Human Monocyte-Macrophage Cultures. J. Virol. 65(11):6362- 6364, 1991. 250. Gendelman, H.E., Baca, L.M., Kubrak, C.A., Genis, P., Burrous, S., Friedman, R.M., Jacobs, D., and Meltzer, M.S.: Induction of IFN-α in Peripheral Blood Mononuclear Cells by HIV-Infected Monocytes. J. of Immunology 148:(2)422-429, 1992. 251. Friedman, Robert M., Yeh, Annie, and Wozhan, Tang: Post-Transcriptional Regulation by Interferon-α of ε-Globin Production in Human Erythroleukemia K-562 Cells. J. of Interferon Research 12:311-316, 1992. 252. Mock, Beverly A., Contente, Sara, Kenyon, Kaylene, Friedman, Robert M., and Kozak, Christine A.: The Gene for Lysyl Oxidase Maps to Mouse Chromosome 18. Genomics 14:822-823, 1992. 253. Contente, Sara, Csiszar, Katalin, Kenyon, Kaylene, and Friedman, Robert M.: Structure of the Mouse Lysyl Oxidase Gene. Genomics 16:395-400, 1993. 254. Kenyon, Kaylene, Modi, William S., Contente Sara, Friedman, Robert M.: A Novel Human cDNA with a Predicted Protein Similar to Lysyl Oxidase Maps to Chromosome 15q24-q25. The Journal of Biological Chemistry 268: (25)18435-18437, 1993. 255. Maheshwari, Radha K., Sidhu, Gurmel S., Singh, Anoop K., Sivaram, Sudha S., Kinchington, Paul R., Hay, John, and Friedman, Robert M.: Defective Transport of Herpes Simplex Virus Glycoprotein in 23 Interferon-Treated Cells: Role of Intracellular pH. Journal of Interferon Research 14:319-324, 1994. 256. Friedman, Robert M., Grimley, Philip, and Baron, Samuel: Biological effects of the interferons and other cytokines. Biotherapy 8:189-198, 1996. 257. Singh, Anoop K., Sidhu, Gurmel S., Friedman, Robert M., and Maheshwari, Radha K: Mechanism of Enhancement of the Antiviral Action of Interferon Against Herpes Simplex Virus-1 by Chloroquine. Journal of Interferon and Cytokine Research 16:725-731, 1996. 258. Su, Zao-Zhong, Yemul, Shrishailam, Estabrook, Alison, Friedman, Robert M., Zimmer, Stephen G., and Fisher, Paul B: Transcriptional switching model for the regulation of tumorigenesis and metastatsis by the Ha-ras oncogene: transcriptional changes in the Ha-ras tumor suppressor gene lysyl oxidase. International Journal of Oncology 7:1279-1284, 1995. 259. Friedman, Robert M., Yeh, Annie, Gutman, Pablo, Contente, Sara, and Kenyon, Kaylene: Reversion by Deletion of Transforming Oncogene Following Interferon-β and Retinoic Acid Treatment. Journal of Interferon and Cytokine Research 17:647-651, 1997. 260. Friedman, Robert M: I Listened to my Grass Roots, But Heard Only Murmurs of Discontent. Cytokine and Growth Factor Reviews, Vol. 8, 2:101, 1997. 261. Friedman, Robert M: Foreword. Journal of Interferon and Cytokine Research 17:Supplement 1:S1 (1997). 262. Contente Sara, Kenyon Kaylene, Sriraman Priya, Subramanyan Savitri, and Friedman Robert M: Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene. Molecular and Cellular Biochemistry 194:79-91, 1999. 263. Naniche Denise, Yeh Annie, Eto Danelle, Manchester Marianne, Friedman Robert M., and Oldstone Michael B.A: Evasion of Host Defenses by Measles Virus: Wild-Type Measles Virus Infection Interferes with Induction of Alpha/Beta Interferon Production. Journal of Virology 74:7478-7484, 2000. 24 264. Contente, Sara, Attard, Frank A., Yeh, Tze-Jou Annie, Buchhagen, Dorothy L., & Friedman, Robert M.: Deregulated Expression of Interferon Regulatory Factor- 1 in Oncogene-Transformed Mouse Fibroblasts. Journal of Interferon & Cytokine Research 23: 639-647, 2003. 265. Attard, Frank A., Contente, Sara, Yeh, Tze-Jou Annie, Buchhagen, Dorothy L., & Friedman, Robert M.: Mechanisms of Deregulation of IFN Regulatory Factor-1 in ras-Transformed Fibroblasts. Journal of Interferon & Cytokine Research 25: 418-423, 2005. 266. Yeh, Annie Tze-Jou, Contente, Sara, & Friedman, Robert M.: Transformation of Revertant Murine Cells by 5-Azacytidine Results in Rapid Inhibition of Lysyl Oxidase Expression. Acta Microbiologica et Immunologica Hungarica 52:433-442 (2005). 267. Contente, Sara, Attard, Frank A., & Friedman, Robert M.: Identification of Proteins Immunologically Related to Interferon Regulatory Factor – 1 That Bind with Interferon Regulatory Factor Element. Journal of Infectious Dis. 194 (Suppl. 1):S27-32 (2006) 268. Friedman, Robert M.: On the Discovery of Interferon. J.Interferon & Cytokine Research. 27: 175-179 (2007) 269. Friedman, Robert M.: Clinical Uses of Interferons. British J.of Clinical Pharmacology. 65: 158-162. 2007 270. (25a). Friedman, R.M.: Effect of interferon treatment on interferon production, J. Immunol. 96: 872-877. 1966. 271. Contente, S., Tze-Jou, Annie, & Friedman, Robert M. Tumor suppressive effect of lysyl oxidase proenzyme. Biochimica et Biophysica Acta. 1793: 1272-1278. 2009 272. Friedman, R. M. & Contente, S. Interferons as Therapy for Viral and Neoplastic Diseases: From Panacea to Pariah to Paragon. Pharmaceuticals 2: 206-216. 2009 273. Friedman, R. M. & Contente, S. Treatment of Hepatitis C Infections with Interferon: A Historical Perspective. Hepatitis Research and Treatment 2: 1-4. 2011 274. Friedman, R. M. Review of Paolo Mazzarello. Golgi. A biography of the 25 Founder of Modern Neuroscience. Oxford University Press, 2010. In Psychiatry 74: 170- 174. 2011 275. Contente, S., Yeh, T-J, & Friedman, R. M. H-Ras localizes to cell nuclei and varies with the cell cycle. Genes & Cancer: 2,166-172. 2011 276. (3a) Friedman, R.M. Chick-cell agglutinating unit. New Eng. J. Med. 264(3),153. 1961 277. (239a) Reid,TR, Race,ER,Wolff, BH, Friedman,RM, Merigan,TC, Basham,TV. Enhanced in vivo therapeutic response to interferon in mice with an in vivo interferon-resistant B-cell lymphoma. Cancer Res. 49, 4163- 69, 1989. 278. Friedman, R.M. Review of Howard Markel. An Anatomy of Addiction: Sigmund Freud, William Halsted and the Miracle Drug Cocaine. In Psychiatry. 75:301-304, 2012. 279. Friedman, R. M. Reviews of Isvan Hagittai. Drive and curiosity: What fuels the Passion for Science and Michael Brooks. Free Radicals: The Secret Anarchy of Science. in Psychiatry 76: 185-6, 2013. 280. Friedman, R. M. Review of Mario Livio. Brilliant Blunders from Darwin to Einstein. Colossal Mistakes by Great Scientists That Changed Our Understanding of Life and the Universe in Psychiatry 77: 102-105, 2014. 281. Friedman, R. M. Review of Stanley B. Prusiner, M.D. Madness and Memory. The Discovery of Prions in Psychiatry, in press 26 TAB 22 Awards and Honors University Medal UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http://www.usuhs.mil 15 September 2014 MEMORANDUM FOR THE PRESIDENT, USU THROUGH: USU BOARD OF REGENTS SUBJECT: University Medal for Mr. Stephen Rice The USU Names and Honors Committee fu lly supports the presentation of the University Medal to Mr. Stephen Rice for 14 years of outstanding service to the Uniformed Services University as Vice President for Finance and Administration. Thank you for your consideration. jtlr,~.J rnf1 L. Andrew I luff. Col. USAF. MC, SI~ Director. AFRRl Chair, USU Namci. & Honors Committee Learning to Care for Those in Harm's u:izy UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAD BETHESDA, MARYLAND 20814-4712 http://www.usuhs.mil 12 September 2014 MEMORANDUM FOR CHAIR, NAMES AND HONORS COMMITTEE SUBJECT: Recommendation for Uniformed Services University Medal In accordance with USUHS Instructions, I nominate Stephen Rice for the Uniformed Services University Medal. Mr. Rice has served at the Uni versity for more than 14 years. He has distinguished himself throughout those years as a devoted servant to the University's mission in the role as Vice President of Finance and Administration. His accomplishments are described in detail in the attached justification and citation. Mr. Rice's dedication and perseverance to the Uniformed Services University are worthy of its highest recognition. Thank you for your consideration. Chjef of Staff Attachments: As stated Learning to Care far 1bose in Harm's Way STEPHEN C. RICE, Vice President for Finance and Administration of the Unifonned Services University of the Health Sciences, is highly deserving of the University Medal. The University Medal is the highest honor the University can bestow and is awarded for making a exemplary and distinguished difference in the academic life of our community of scholars. Mr. Rice exemplifies the qualities of the ideal academic administrator: he learned and understands the academic enterprise and with honesty, dedication, professionalism, and versatility worked to support the scholarship of the members of the University and secure the academic values of the institution now and into the future. His 14 years of University service made the Uniformed Services University a permanently better academic institution. In November 2000, upon his retirement from active naval service, Mr. Rice joined the Uniformed Services University of the Health Sciences as Vice President for Resource Management. In May 2006, he was promoted to Vice President for Finance and Administration, where he was responsible for all facets of financial services, acquisition management, civilian personnel, logistics, facilities, health and safety, and administrative support functions for military medicine's premier academic instirution. Experienced in graduate professional education as a Health Care Administrator during his naval career, Mr. Rice worked diligently to understand the scholarly conununity and academic enterprise that was the Uniformed Services University. During his tenure at the Uniformed Services University of the Health Sciences, Mr. Rice demonstrated exceptional leadership, vision, and management expertise as he shepherded the University though unprecedented growth and mission expansion, under the most difficult circumstances. His efforts secured the University as it moved from a post doctor draft medical officer accession source to a multipurpose educational & research institution serving diverse needs in the National Security Strategy in a complex post-Cold War world. Mr. Rice appreciated that the strength of the University lay in the collective scholarly achievements of the members of the community, faculty and student. While student recmitment was excellent, the faculty was aging and vulnerable, He recognized that the University recruited faculty in a national market and led the effort to establish a reliable and relevant data source to use as the basis for salary setting for the faculty and staff of the University. His tireless efforts to improve the University' s ability to recniit and retain top faculty educators and researchers is evidenced by his accomplishments in: obtaining programmatic resources to suppo1t Faculty Recruitment & Retention; managing the Merit Pay Pool process; guiding and securing approval for AD salary schedules and retention authorities; and overseeing multiple hiring packages. Significantly, he worked with DCPAS, Wage and Salary Branch to implement the new salary and pay provisions for University after the passage of the 2008 NDAA. As a result of his direct involvement and leadership, USU implemented the NDAA intent for comparable compensation for faculty and staff, which has been a boost to recruitment and retention of high caliber faculty. Moreover, with the passage of2008 NDAA, Mr. Rice succeeded in removing the pay limitations of 5 USC 5373. In addition, pay flexibility was granted for the GSN salary schedule to increase the total pay maximum for each rank up to 35% for Certified Registered Nurse Anesthetist (CRNA). This pay provision in conjunction with USU recruitment and retention pay provisions of up to 25%, gave the GSN the ability to hire the school's first faculty CRNA. This was a significant achievement for the GSN as the GSN was unable to hire a CRNA faculty member due salary constraints prior to September 201 0. These efforts were vital to preserve the competitive status of the University and ensure that the University recruited and retained the best scholars the Nation has to offer; preserving the ability of the University to continue to graduate the future leaders and educators of the Military Health System. Furthermore, he recognized scholarly recruitment was not just a matter of salary, but also of research opportunity. He created the process supporting new hires, structuring the hiring promise letter and creating the "package" concept of post~doctoral fellows, equipment funds, and supplies. In addition, he provided resource expertise and experience to complete the financial commitments and salary recommendations for a number significant recruitment packages, including Deans, Vice Presidents, SOM Chairs and senior Academic Administrator hiring promises, to include Surgery, OBGYN, Radiology, Military and Emergency Medicine, Rehabilitative Medicine, Neuro1ogy, Anesthesiology, and Associate Dean for Medical Education. Each negotiation was ultimately successful and carefully balanced the interests of the University and the individual in question. Mr. Rice's maturity as an academic administrator led to the realization that research efforts over years required predictability and planning._His successes included establishment of two new categories of support cost recovery, a Federal Compliance Cost (FCC) and a Post-Award Off Site. In addition, he continued liaison with the Office of Research and HJF on Indirect Rates and the Under Recovery Program to facilitate research efforts and appropriately reimburse USU for infrastructure support of sponsored programs. Significant research infrastructure capabilities were added during his tenure, most notably, a PET/MRI scanner for neuroscience research, a Cobalt lrradiator and Cesium 147 Irradiator at USU, and a Linear Accelerator at AFRRI for radiobiological research. In addition, over $SOM was invested in other replacement and upgraded research equipment. His personal leadership on several Oversight Committees, including the Center for Neuroscience and Regenerative Medicine, Center for Prostate Disease Research and U.S. Military Cancer Institute was vital to advancing DoD's research interests while ensuring effective resource utilization. Mr. Rice's administrative experience provided insight into the vulnerability of many of the University's scholarly programs. These excellent programs were individualistic and idiosyncratic, their long term stability required placement within the ongoing base funding of the University. During his tenure, he oversaw the addition of~ $1 Billion in new programs to the base USUHS budget (now representing about $125M annually). These programs include the: Curriculum Review, Center for Neuroscience and Regenerative Medicine, Graduate School of Nursing, Faculty Recruitment and Retention, the Center for Prostate Disease Research, the TriService Nursing Research Program, and many others. Most members of the academic community are immune to issues of appearance and infrastructure until it impacts their scholarship. Mr. Rice justified the inclusion of a Restoration & Modernization line item in the University's financial profile, enabling substantial investments in the University and AFRRI physical facilities. As a result of his initiative, innumerable long standing deficiencies have been addressed, including renovations of classroom and lecture halls, laboratories, as well as HVAC, garage, roof repairs and other renovations. Prior to Mr. Rice's arrival, no labs had been renovated since they had been built. To date, under his laboratory Renovation program, 120 labs have been renovated and USU has a program in place to renovate every lab on a twenty year refresh cycle. To equip these renovated labs Mr. Rice pioneered the Equipment Unfunded Requirement Review Committee and the process that supports it. Since inception this process has prioritized and secured funding for ~$1 OM of equipment to support the teaching and research missions of the University. Mr. Rice worked closely with the Senior VP/Executive Dean PDC on funding for space, equipment, and furnishings to support current and future University operations in San Antonio. This was a significant milestone in the history of USU, marking the first time USU expanded its presence into another MHS center of gravity installation. Mr. Rice was instrumental in establishing collaborative relationships within DoD and with other federal partners to fully leverage appropriated funds. One such partnership was with the National Institutes of Health to fund the refueling of the cobalt source, thus preserving the Nation's capacity to conduct high throughput ionizing radiation research critical to our Nation's defense. Mr. Rice's exceptional ability to acquire and execute resources to further the academic mission of the University is unsurpassed. In the area of education, his efforts paved the way for creation and expansion of several programs addressing key DoD manning requirements, such as psychiatric mental health advanced practice nurses, certified registered nurse anesthetists, neuroscience and emerging infectious disease. In addition to adding funds to the core USUHS budget for new programs, Mr. Rice was also successful in getting resources transferred to the USUHS core program from other sponsors, most notably RDT&E Funds. When Mr. Rice arrived at USU there were no RDT&E funds in the USU program, whereas now the USU intramural program is funded at -$24M/year. Mr. Rice demonstrates the basic skills of financial and administrative management that would be expected of any senior government administrator; he expertly has led the University in fiscal years with multiple continuing resolutions, sequestration, a government shutdown, and throughout times in which cash flow, travel restrictions, FTE and contract ceilings were imposed, all the while through ensuring mission accomplishment and averting as much turmoil as possible for the faculty and staff. He steadfastly developed financial allocation and sequestration plans, identifying programs and commodities for reduction or elimination to meet Congressionally imposed budget targets. His plans protected all core USU missions and always minimized disruption to USU operations to the greatest extent possible. He has improved human capital management systems and process, often in spite of efforts to "improve" personnel management at the Federal level, for example, though careful planning and oversight he made the NSPS process work for USU employees. But what sets Steve Rice apart is his appreciation of the academic purpose of academic administration - the resources support and the administration facilitates education and research of students and faculty and so make possible a University. Mr. Rice is a member of the community of scholarship, USU is his University, and it is with pride that we number him among our permanent alumni by the award of the University Medal. 1 CITATION 2 TO ACCOMPANY THE AWARD OF THE 3 UNIVERSITY MEDAL 4 TO 5 MR. STEPHEN C. RIC E 6 The President of the Uniformed Services University, on the recommendation of the faculty and 7 the with the advice and consent of the Board of Regents, awards the University Medal to Mr. Stephen C. 8 Rice for exceptionally distinguished service as the Vice President for Finance and Administration for the 9 Uniformed Services University of the Health Sciences from November 2000 through May 2014. During 10 this period Mr. Rice demonstrated exceptional leadership, vision, and management expertise of a gifted 11 academic administrator, facilitating unprecedented growth and academic development in University 12 programs. His efforts to understand and support the academic mission first stabilized and then grew the 13 University resource portfolio as the institution matured from a Cold War medical officer accession 14 source to a multipurpose educational & research institution serving diverse needs in the National 15 Defense strategy in a complex world. Mr. Rice quickly appreciated that the University acquired faculty 16 in a national academic market and so led the effort to establish a reliable and relevant data source to 17 use as t he basis for salary setting for the faculty and staff of the University. In concert with other leaders 18 he created the process for supporting new hires through structured hiring promise letters. These efforts 19 were vital to preserve the competitive status of the University and ensure that the University recruited 20 and retained the best scholars the Nation has to offer; preserving the ability of the University to 21 continue to graduate the future leaders and educators of the Military Health System. The excellence of 22 the faculty led to a variety of new scholarly programs supporting aspects of the National Security 23 Strategy but the programs were individualistic special interests, Mr. Rice's extraordinary leadership skills 24 and dedication were vital to the reprogramming of resources from within the Department to the 25 University to support such diverse, expanded missions as: the Armed Forces Radiobiology Research 26 Institute, the Graduate School of Nursing, the Consortium for Health and Human Performance, and the 27 Center for Neuro-Science and Regenerative Medicine. During his tenure Mr. Rice further demonstrated 28 his skill as an academic administrator by developing and implementing a program of laboratory 29 renovation allowing University scholars to keep pace with the peers in the scholarship of discovery. He 30 served the entire community in his efforts to recapitalize the University infrastructure and create 31 programed funding to support restoration and modernization efforts going forward. Mr. Rice was 32 instrumental in establishing collaborative relationships within DoD and with other federal partners to 33 fully leverage appropriated funds. Mr. Rice's ability to acquire and execute resources to expedite the 34 translation of research from bench to battlefield was key to numerous clinical and translational research 35 programs that improved to the care delivered to our nation's warriors. Mr. Rice exemplifies the ideal 36 academic administrator: understanding and supporting the academic enterprise of the University with 37 honesty, dedication, professionalism, and versatility. The extraordinary accomplishments of Mr. Rice 38 reflect great credit upon himself and dramatically improved the Uniformed Services University and so he 39 is permanently numbered among the members of our community of scholars. 40 TAB 23 USU President’s Report USU President’s Report Charles L. Rice, MD • Honor Code • Board of Regents Candidate o Leo Rouse, DDS (Attachment 1) o Caswell Evans, DDS (Attachment 2) o Harold Slavkin, DDS, PhD (Attachment 3) • FTE Constraints • Military Manpower Study • National Heart, Lung, and Blood Institute Project • New Salary Schedules • Enlisted to Medical Degree Preparatory Program October 2014 Attachment 1 Curriculum Vitae Leo E. Rouse, D.D.S., L.H.D. (Hon.), F.A.C.D. Professor of Clinical Dentistry Dean EDUCATION 2014- Honorary Degree, Doctor of Humane Letters, Western University of the Health Sciences 1969-1973 Doctor of Dental Surgery, Howard University College of Dentistry 1965-1969 Bachelor of Science, Pre Dental, Howard University MILITARY 1976-1978 Certificate, Comprehensive General Dentistry, Walson Army Hospital 1984 Certificate, Army Medical Department Faculty Development Course 1986 Diploma, U.S. Army Command and General Staff College 1994 Diploma, U.S. Army War College PROFESSIONAL AFFILIATIONS American Dental Association National Dental Association American Association of Dental Boards American Dental Education Association North East Regional Board of Dental Examiners PROFESSIONAL RECOGNITION Fellow, American College of Dentists Omicron Kappa Upsilon Honor Society Chi Delta Mu Professional Fraternity Scabbard and Blade Military Honor Society Order of Military Medical Merit #2002 OTHER AFFILIATIONS Alpha Phi Alpha Fraternity, Inc. Life Member ABSTRACT OF PROFESSIONAL SERVICE Oct 2013-Dec 31, 2013 Interim Deputy Provost for Health Sciences 2004-Present Dean, Howard University College of Dentistry 2003-2004 Interim Dean, Howard University College of Dentistry 1997-2003 Associate Dean for Clinical Affairs and Chairman, Department of Clinical Dentistry, Howard University College of Dentistry. 1995-1997 Commander and Chief Operating Officer, U.S. Army Dental Command, Fort Sam Houston, TX 1993-1995 Commander, 163rd Medical Battalion (DS), 18th Medical Command, Dental Surgeon US Forces Korea/Eighth US Army. 1991-1993 Chairman, Department of Dental Sciences and Dental Corps Advisor, Army Medical Department Center and School, Fort Sam Houston, TX. Consultant, Military Academic Affairs to Surgeon General. 1989-1991 Commander, US Army Dental Activity, Fort Devens, MA 1973-1989 Clinician, Resident, Clinic Chief, Instructor, Chief Instructor, Class advisor and Branch Chief Honors – Military Legion of Merit (One Oak Leaf Cluster) Meritorious Service Medal (Five Oak Leaf Clusters) Army Commendation Medal Army Achievement Medal (One Oak Leaf Cluster) National Defense Medal Army Service Medal Army Overseas Medal (One Oak Leaf Cluster) Honors – College of Dentistry Howard University College of Dentistry [HUCD] Alumni Achievement Award – 1997 HUCD Student Council Award for Outstanding Support – 1998 HUCD Class of 1998 Excellence in Service Award HUCD Student Council Award for Dedicated Service – 1999 HUCD Class of 1999 Exemplary Service Award HUCD Class of 2000 Exemplary Service Award HUCD Student Council Award for Exemplary Service to Students – 2001 HUCD Class of 2001 Outstanding Administrator Award HUCD Class of 2002 Outstanding Administrator Award Honors – Professional American Dental Education Association Presidential Citation – 2009 National Dental Association President’s Award – 2010 District of Columbia Dental Society Sterling V. Mead Award – 2011 National Dental Association Legend Award - 2011 PROFESSIONAL FELLOWSHIPS Fellow, Academy of General Dentistry 1980 Fellow, International College of Dentists 1990 Fellow, American College of Dentists 1998 APPOINTMENTS 1999-2013 Examiner Consultant & Member, North East Regional Board of Dental Examiners. 1997-Present Executive Committee, Howard University College of Dentistry. 1998-2000 Reviewer, Academic Fund for Excellence Grant Program, Howard University. 2003-2008 Member, Examination Committee, North East Regional Board of Dental Examiners. 2 2002-2006 Member, University-Wide HIPAA Committee. 1998-1999 Chairman, Howard University College of Dentistry Restructuring Committee. 2005-2007 Minority Affairs Advisory Committee, American Dental Education Association. Chair, 2006-2007 2005- Present Member, DENTSPLY International Education Advisory Committee. 2007- 2008 Treasurer, Board of Directors, Student Clinicians ADA [SCADA] Dentsply International. 2008-2009 Secretary, Board of Directors, Student Clinicians ADA [SCADA] Dentsply International 2009-2010 Vice Chair, Board of Directors, Student Clinician ADA [SCADA] Dentsply International 2010-2011 President, Board of Directors, Student Clinician ADA [SCADA] Dentsply International 2009-2010 President, Board of Directors, Association of Minority Health Professional Schools [AMPHS]. 2009-Present Member, Board of Directors of the National Children’s Oral Health Foundation [NCOHF] 2006-2007 Member-at-Large, Council of Deans, American Dental Education Association. 2007-2008 Vice-Chair, Council of Deans, American Dental Education Association 2009-2010 Chair, Council of Deans, American Dental Education Association. 2007-2013 Member , American Dental Association Foundation Board of Directors. 2010-2011 President-Elect, American Dental Education Association 2011-2012 President, American Dental Education Association 2012-Present Immediate Past President, American Dental Education Association 2010-2011 Representative Member, ADEA to the Expert Panel for Core Competencies for Interprofessional Collaborative Practice (IPEC) 2011-Present Member, Board of Visitors, University of Pittsburgh School of Dental Medicine 2012-Present Member, Board of Directors, Oral Health America 2013-Present Member, the National Advisory Council of the National Center for Interprofessional Practice 2013-Present Onsite Advisor/Mentor, American Dental Education Association/Academy for Academy Leadership-Leadership Institute 2014-Present Member, Board of Visitors, Meharry Medical College School of Dentistry. SELECTED PEER-REVIEWED PUBLICATIONS Rouse, L.E., Welsh, S.C., Schwab, J.I., A Techniques for the Repair of a Fractured Crowned Tooth, Fall I ssue/Journal of the New Jersey Dental Association. 1977. Rouse, L.E., Hays, G.C., Dental Considerations: Sickle Cell Anemia. Journal of the Academy of General Dentistry. Nov-Dec 1979. Liewehr, F., Rouse, L.E., A Preclinical Model for Exodontia, Journal of Dental Education Vol. 56/No. 6. 1992. Sanz, M., Rouse, L., Profile of the dentist in the oral healthcare team in countries with developed economies. European Journal of Dental Education. Sept 2007. 3 Henley, G.L., Rouse, L.E., Skinner, C., Predicting successful matriculation through basic science curriculum at Howard University, Journal of Dental Research, Special Issue, 2005. Rouse, L.E., ADEA President-Elect Address, Journal of Dental Education, July 2011. Henley, G. L., Hughes, G.B., Feimster, T., Rouse, L.E., Chapter 4, Parsing Banner Downloaded Data into a Flat-File Format for Analysis, Cases for Institutional Research Systems, IGI Global, 2012. Rouse, L.E., ADEA President’s Address, Journal of Dental Education, July2012. Winfree, W.J., Rouse, L.E., Brown, R.S., Body Dysmorphic Disorder and Cosmetic Dentistry, Diagnostic, Management, and Ethical Issues, Dentistry Today, March 2014. PRESENTATIONS AVAILABLE UPON REQUEST 4 Attachment 2 CURRICULUM VITAE Caswell A. Evans, Jr., D.D.S., M.P.H. PERSONAL DATA Work Address: University of Illinois at Chicago College of Dentistry (MC 621) 801 South Paulina Street, Room 102GD Chicago, IL 60612 Home Address: Date / Place of Birth: PRESENT POSITION(S) July 2004 – Present Associate Dean for Prevention and Public Health Sciences University of Illinois at Chicago, College of Dentistry Director, Division of Prevention and Public Health Sciences – center point for the prevention curriculum and related public health curriculum and training experiences. Course Director, DCLE 341-2-3: Extra-mural Education. The D4 course represents 15 units of credits; it is graded and requisite. D4 students gain half of their clinical experience (approximately 60 days) in community-based service-learning environments. Affiliation agreements crafted with 21 sites in Chicago and Illinois; but also including sites in Colorado, Guatemala, China and Tanzania. Adjunct faculty are credentialed at each site. The course includes didactic elements, reflective essays, reflective seminars, and evaluations by faculty and students. Initiated 2005. Human Research Review Committee, Department of Pediatric Dentistry (2005 – present) Chair, Dental College search committee for Associate Dean for Research (2007) Lectures in DBSC 341 (D3) course: U.S Health Care System, and U.S. Dental Care System 2005-Present Lectures in DBSC 310 (D2) course: Dental Public Health (2005- present) Faculty Advisor: Student Chapter, American Association of Public Health Dentistry Goldie’s Place Student-run Clinic Schweitzer Fellowship Program Student National Dental Association Faculty Coach: students as requested Master of Science thesis committee for Jennifer Lee Caplin, DMD, “The relationship between Caries and Malocclusion in Migrant Children in China” (2014) UIC Health Workforce Development Task Force appointment (2013 – present) National Academy Members Nomination Committee, UIC Chancellor’s Advisory Committee (2010 – Present) Caswell A. Evans, Jr., D.D.S., M.P.H. 2 UIC Center for Global Health, Internal Advisory Committee (2012 – present) UIC Healthcare Delivery Grants and Contract Review Board (2012 – present) Search Committee appointment, UIC Cancer Center, Assistant Director for Cancer Prevention and Population Sciences Research (2008 - 2009) Search Committee appointment, UIC Vice Provost for Budget and Resource Planning and Associate Chancellor (2012 - 2013) Search Committee appointment, Dean UIC College of Dentistry (2013) Candidate interview panel, UIC Vice President for Health Affairs (2012) Candidate interview panel, UIC Associate Vice President, Community Based Practice (2012) National Advisory Board, Project EXPORT, UIC College of Medicine, Rockford, IL branch (2004 – 2008) Professor, UIC School of Public Health; joint appointment (2004 – present) Lectures in HPA 400, Principles of Management in Public Health (2005 – present) Development of a dual degree DDS-MPH program; in discussion and process Visiting Professor, Columbia University School of Dental and Oral Surgery, New York City, NY PREVIOUS POSITIONS June 2002 – Director, National Oral Health Initiative June 2004 Office of the US Surgeon General, Washington, DC Represent the Surgeon General providing guidance and assistance to initiatives responsive to the “Call for Action” articulated in Oral Health in America: A Report of the Surgeon General Surgeon. Initiate the development and completion of the National Call To Action To Promote Oral Health, released April 2003. April 1998 - 2004 Adjunct Associate Professor Howard University, School of Medicine, Washington, DC May 1997 – Project Director and Executive Editor, U. S. Surgeon General’s Report on Oral June 2001 Health (via Interagency Personnel Agreement between Los Angeles County and the U. S. Department of Health and Human Services) Develop report concepts and track process. Identify and guided the work of authors, reviewers, and subject editors. Develop timelines and monitor the progress. Manage actions and issues related to the report. Develop broad-based partnerships with foundations, private market sector, and associations. Represent the Surgeon General as necessary regarding the report. The U.S. Surgeon General released the 308-page report on May 25, 2000. Caswell A. Evans, Jr., D.D.S., M.P.H. 3 October 1996 – Assistant Director of Health Services; Director, Office of Public Health Initiatives, June 2001 Los Angeles County Department of Health Services, Los Angeles, CA (concurrent assignment) Plan and implement broad based public health outreach/ education advocacy strategies that promote the public health mission; direct efforts on specific local public health initiatives, such as ensuring optimal fluoridation of Southern California’s water supply and expanding local health and faith partnerships. May 1988 – Adjunct Professor, School of Public Health, June 2001 University of California, Los Angeles, CA July 1987 – Adjunct Professor, School of Dentistry, June 2001 University of California, Los Angeles, CA July 1986 – Associate Professor, Community Medicine, June 2001 Charles R. Drew University of Medicine and Science, Los Angeles, CA July 1985 – Director, Public Health Programs and Services, Assistant Director of Health October 1996 Services, Los Angeles County Department of Health Services Executive administration of Public Health Programs and Services comprised of health promotion, disease prevention and health protection, including environmental health services, Alcohol and Drug Abuse Programs, AIDS Programs, California Children Services, Violence/Injury Prevention, and Juvenile Court Health Services. Through subordinate deputy directors, administrators, and medical managers, plan, organize, direct, implement, and control all administrative, medical, and policy functions of public health programs. Represent the Director of Health Services as requested and assigned. Budget: $340 million; staff: 3200 FTE. • Beyond the administrative duties described above, significant accomplishments include: • Reorganized and consolidated public health in the Department by creating and developing the Public Health Programs and Services division. • Developed a new mission statement for public health beyond the traditional model of disease control and prevention by focusing on a broader range of community preventive services, including such programs as tobacco cessation and prevention, alcohol and drug abuse prevention, cancer prevention, and injury/violence prevention. • Launched and led successful campaign to optimally fluoridate the City of Los Angeles’ municipal water supply. (Received the American Dental Association’s Council’s Choice Award, 2001, in recognition of this effort.) • Initiated a collaborative community effort to market public health, known as Public Health Week, now celebrated nationally. • Developed the Great Beginnings for Black Babies campaign to encourage pregnant African-American women to seek early and continued prenatal care. • Applied the national Year 2000 health objectives to the local level by creating the Healthy Los Angeles 2000 coalition consisting of academic, practicing, and community public health professionals. Caswell A. Evans, Jr., D.D.S., M.P.H. 4 • Founded the Health and Faith Coalition of Greater Los Angeles in collaboration with the Greater Hollywood Health Partnership (16 congregations) and the Southern Area Clergy Council (65 congregations). January 1980 – Director, King County Health Services Division, Seattle-King County Department of June 1985 Public Health, Seattle, WA Direct the work of and administer the King County Health Services Division; direct the provision of public health services and the enforcement of laws, rules and regulations pertaining to public health in the county. Significant accomplishments include: • Developed the County Services Division within the newly reorganized department. • Established standards for program performance and public health practice guidelines for the new division • Expanded operations through successful proposals to open additional public health service sites; worked collaboratively with consortia of community clinics to expand the service delivery platform. July 1979 – Director of Operations, Seattle-King County Department of Public December 1979 Health Direct the work of and administer the Operations Division, responsible for providing public health services, personal and environmental services in Seattle and King County. Significant accomplishments include: • Managed the phase out of the division as part of the Department’s reorganization. October 1974 – Chief of Dental Services, Seattle-King County Department of Public June 1985 Health (concurrent with positions above beginning, July 1979) Administer and coordinate programs of dental care and dental disease prevention; identify program objectives, capacities and treatment priorities; establish program policies and procedures; evaluate programs and services in Seattle-King County. Significant accomplishments include: • Led successful campaigns to preserve water fluoridation in the City of Seattle; initiated water fluoridation in the City of Renton, Washington (King County); and defeated an Initiative that would have prohibited community water fluoridation statewide. • Expanded the service in terms of clinic sites and staff; initiated use of occlusal sealants and fluoride mouth rinses in schools. Caswell A. Evans, Jr., D.D.S., M.P.H. 5 October 1974 – Affiliate Assistant Professor of Community Dentistry, School of Dentistry, University June 1985 of Washington, Seattle, WA. Member, Admissions Committee. October 1974 – Clinical Assistant Professor of Epidemiology and International Health, School of June 1985 Public Health and Community Medicine, University of Washington. July 1973 – Chief of Dental Services; and Director of Research and Evaluation, HEALTHCO, September 1974 Inc., Soul City, North Carolina Plan, develop and operate the dental component of a new 314e Comprehensive Health Care Center. Develop and coordinate all data collection and reporting systems, and establish program evaluation criteria for the health center. July 1973 – Assistant Professor of Dentistry, Department of Dental Ecology, School of Dentistry, September 1974 University of North Carolina, Chapel Hill, NC. Member, Admissions Committee. EDUCATION A.B. Franklin and Marshall College. Lancaster, PA - 1965. Major: English D.D.S. Columbia University, School of Dental and Oral Surgery. New York, NY – 1970 Internship Zoller Memorial Dental Clinic, University of Chicago Hospitals and Clinics. Certificate Chicago, IL – 1971 M.P.H. University of Michigan, School of Public Health. Ann Arbor, MI – 1972 Residency University of Michigan, School of Public Health. Certificate Ann Arbor, MI – 1973 PROFESSIONAL CERTIFICATION American Board of Dental Public Health; Diplomate 1985. Northeast Regional Board Certification in Dentistry. Licensed to practice dentistry: Washington. Restricted Faculty Licenses: Illinois CONSULTANT, ADVISORY AND OTHER PROFESSIONAL ACTIVITIES (SELECTED) 2012-2015 Advisory Committee on Training in Primary Care Medicine and Dentistry, HRSA, appointed by DHHS Secretary Kathleen Sebalious; elected Chairman 2012. 2010-2013 National Academies’ Report Review Committee, representing the Institute of Medicine Founding member and Executive Committee of the Board, U. S. National Oral Health Alliance 2010 – Present Caswell A. Evans, Jr., D.D.S., M.P.H. 6 2010 - Present Board of Governors, Institute of Medicine of Chicago 2010 – Present Board member, Oral Health America 2010 - Present Chicago Partnership for Public Health, steering committee 2010 - Present Board of Directors and vice-Chair, A.C.T.S. of F.A.I.T.H, Chicago, IL (Actions Connected To Spirituality: Forming Alliances In Transforming Health) 2009-Present Advisory Board, Project Salud y Paz (Quetzaltenango, Guatemala) 2009-Present Board of Directors, DentaQuest Foundation, Boston, MA; elected Vice-Chair 2011; elected Chair 2012 2009-Present Advisory Council of the Chicago Albert Schweitzer Fellowship 2008-Present Board of Directors, National Oral Health Policy Center 2008-2011 Commission Consultant, Council on Dental Accreditation (CODA) 2007-Present Chicago Board of Health, appointed by Mayor Richard M. Daley 2007-2010 Chair, Alaska Dental Health Aide Therapist National Advisory Committee, W.K. Kellogg Foundation 2006-2012 Illinois State Board of Health, gubernatorial appointment for three-year term; reappointed 2010 2005-2014 Board of Directors, Otho S. A. Sprague Memorial Institute, Chicago, IL 2004-2008 Review Committee on Dental Public Health, Commission on Dental Accreditation, American Dental Association 2004-Present Board of Directors, Children’s Dental Health Project, Washington, D.C. 2003-2007 Board of Visitors, Samuel D. Harris National Museum of Dentistry, Baltimore, MD 2001-2007 Chair, National Advisory Committee, Pipeline, Profession & Practice: Community-based Dental Education grant program, The Robert Wood Johnson Foundation. 1999-2001 Committee on Community-Level Programs for Youth, a collaborative project of the NRC and NIH; report Community Programs to Promote Youth Development published by National Academy Press, 2001. 1998 Chair, Dental Public Health Specialty Examination Committee, Oregon Board of Dentistry. 1997-2001 Consultant, Department of Corporations, State of California. 1997-1998 Scientific Review Panel, National Health and Nutrition Examination Survey IV, National Center for Health Statistics, DHHS. 1996-2001 Chair, Task Force on Community Preventive Services, Centers for Disease Control and Prevention (CDC). 1996-1999 National Advisory Dental Research Council, National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH). Caswell A. Evans, Jr., D.D.S., M.P.H. 7 1995-2005 Editorial Board, Journal of Health Communication. 1995 Public Health Functions Steering Committee, Office of the Assistant Secretary of Health, DHHS 1995 California Coalition for Childhood Immunizations 1994-2000 Medicine/Public Health Initiative, National Committee. 1993 Prevention in Health Care Reform Advisory Group, Contract Report to the California Wellness Foundation. 1992-1997 Professional Advisory Committee, UCLA School of Public Health, Department of Health Services. 1990-1993 Advisory Board, Southern California Injury Prevention Research Center. 1989- 1997 Executive Committee, National Black Leadership Initiative on Cancer, Western Region. 1988-1992 California AIDS Leadership Committee, State Department of Health Services. 1988-1993 Alumni Society Governing Board, School of Public Health, University of Michigan. 1988-1989 Council on Education in Public Health, Task Force on Long Term Financing of Accreditation . 1985-1991 Chair, Los Angeles County Hazardous Materials Coordinating Council. 1985-1987 Board of Directors, Los Angeles Regional Family Planning Council, Inc. 1983 Panel Member, NIH Consensus Development Conference on Dental Sealants in the Prevention of Tooth Decay. 1980-1983 National Caries Program Advisory Committee, National Institute of Dental Research; NIH. 1980 Medical Audit Team, Washington State Penitentiary at Walla, Walla. 1978-1981 Washington State Health Coordinating Council (Gubernatorial appointment); Chair, Education and Implementation Committee; Member, Executive Committee 1979, 1981. 1978-1981 Primary Care Center Review Committee, DHHS Region X. 1977-1984 Board of Directors, King County Health Planning Council; Chair, Minority, Disadvantaged and Handicapped Committee 1978-79. 1975-1985 Health Services Advisory Committee, Seattle-King County Head Start Program; Chair 1977-78, 1984 1975-1985 Dental Consultant, Head Start Program, DHHS Regions IV and X. PROFESSIONAL ORGANIZATIONS American Public Health Association: President (1994-95) Caswell A. Evans, Jr., D.D.S., M.P.H. 8 Treasurer (1986-92) Executive Board (1986-1992; 1993-1996) Governing Council (1985-1992; 1993-present) Oral Health Section: Chair (1984) Founder, Caucus on Public Health and the Faith Community (1996); Chair 1996; 2000-2002 Nominating Committee, Chair (2004-2005) Institute of Medicine Planning Committee, Interest Group 8: Health of Populations/Health Disparities (2010-2013, Committee Chair 2012 and 2013) Chair, IOM Section 9 (2006-2007) Membership Committee (2004-2007) Report Review Committee, National Academy of Sciences (2010-present) Report Review Committee Monitor: Future Directions for the National Healthcare Quality and Disparities Reports (2010) Relieving Pain in America (May 2011) A Plan for Evaluating the District of Columbia’s Public Schools (2011) International Animal-Research Regulations: Impact on Neuroscience (2012) Educating the Student Body: Taking Physical Activity and Physical Education to School (2013) Evaluating Obesity Prevention Efforts: A Plan for Measuring Progress (2013) Committee on Oral Health Access to Services (2010 – 2011); report: Improving Access to Oral Health , Care for Vulnerable and Underserved Populations, July 2011 Annual Meeting, session moderator: The Health of Populations: Networks, Neighborhoods, Disparities and Health (2008) Committee on Community-Level Programs for Youth; report Community Programs to Promote Youth . Development (2001) Public Health Roundtable (1995-96) Review Panel on Needle Exchange and Bleach Distribution Programs (1993-1995) National Association of County and City Health Officials Board of Directors (1994-1997) Environmental Health Advisory Committee, Member (1995-1997) United States Conference of Local Health Officers: Board of Directors (1991-94) Executive Committee (1993-94) Co-Chair, Minority Health Committee (1993-94) Washington State Public Health Association: President (1980-81) Executive Committee (1976-81) American Board of Dental Public Health Board Director (1997-2003) President 2002-2003. American Association of Public Health Dentistry President (2007-2008) Executive Council (2005-2009) American Dental Education Association Legislative Advisory Committee (2006 – present) Institute for Policy and Advocacy (2007 – present) Task Force on Education or New Oral Health Professionals (Participating Observer, 2010 – present) Caswell A. Evans, Jr., D.D.S., M.P.H. 9 Technical Advisory Committee for the Dental Pipeline National Learning Institute American Dental Association National Dental Association Hispanic Dental Association American Public Health Association Illinois Public Health Association Institute of Medicine of Chicago American College of Dentists -- Fellow International College of Dentists - Fellow Academy of Dentistry International - Fellow Public Health Leadership Society US - Mexico Border Health Association: Governing Council (1990-93) Washington State Association of Black Health Care Professionals, Board of Directors; Founding Member. GRANTS AWARDED 2008-12 Pipeline Approach to Changing Community-Based Dental Practice Patterns. Illinois Children’s Healthcare Foundation. Principal Investigator 2007-08 Piloting community-based service-learning of student clinical time and increasing URM matriculation. Robert Wood Johnson Foundation. Principal Investigator 2005-08 Dental/Community Partnerships Responding to the Illinois Silent Epidemic. Robert Wood Johnson Foundation. Pricipal Investigator 1989-94 Cancer Prevention Research Unit (RFP #88-CA-06) National Cancer Institute, NIH; Co- Principal Investigator. 1986-91 Cancer Control Technical Development in Health Agencies (RFP #86-CA-01) National Cancer Institute, NIH; Principal Investigator. 1977 Skill Development in Dental Public Health Programming (#10-A-7-06043-01), DHEW Short- term Training Grant, Seattle, Washington. 1974 Refunding proposal for HEALTHCO, Inc., (#04-H00817-01-0) Grant awarded by Community Health Services Division, HSHMA, DHEW. 1973 Evaluative Models for the Appraisal of the Quality of Dental Care Programs (RFP #NIH 73- 4010 [P]) conference of same title conducted in Ann Arbor, Michigan. HONORS Honorary Doctorate in Science, Franklin and Marshall College, Commencement Ceremony, 2014 Distinguished Service Award, the American Association of Public Health Dentistry, 2013 Ascend the Summit Leadership Circle Award, the National Dental Association and the Colgate- Palmolive Company, 2012 Caswell A. Evans, Jr., D.D.S., M.P.H. 10 Distinguished Scholar and Fellow, National Academies of Practice, designated 2012 National Associate (lifetime honor), National Research Council of the National Academies, 2011 2011 William J. Gies Award for Achievement – Dental Educator; ADEA Gies Foundation, 2011 Oral health delegation leader to China. People To People Citizen’s Ambassador Program, 2008 Shils Award: Edward B. Shils Entrepreneurial Education Fund, 2007 William Thomas Green Morton National Award for the Advancement of General Dentistry, 2007 Laureate, 2007 President’s Award, National Dental Association, 2006 Fellow, Academy of Dentistry International, 2006 Presidential Citation, American Dental Education Association, 2005 Surgeon General’s Exemplary Service Award, awarded by Surgeon General Richard H. Carmona, 2004. Exemplary Service Award, commendation by the Chief Dental Officer, US Public Health Service, 2004. Featured (January), 2004 African American History Calendar, Aetna, Inc. www.aetna.com/diversity/aahcalendar/2004/index.html Speaker, Raymond L. Hayes Distinguished Professor Lecture Series, Omicron Kappa Upsilon, Pi Pi Chapter National Dental Honor Society Induction ceremony, Howard University College of Dentistry, Washington, DC, April 22, 2003. Oral Health Delegation Leader to Cuba. People To People Citizen’s Ambassadors Program, 2003 Featured, Leaders in Dentistry, International College of Dentists’ videotape series; October 18, 2002.http://usa- icd.org. Featured, National Museum of Dentistry, Baltimore, MD, The Future is Now! African Americans in Dentistry exhibit; September 27, 2002 through August, 2003. Nomination, Charles C. Sheppard Science Award for most outstanding peer-reviewed research paper published by CDC/ATSDR during 2001. Paper title: “Reviews of Evidence Regarding Interventions to Reduce Alcohol- Impaired Driving.” Inaugural Annual David Satcher Keynote Address, Commissioned Officers Association, US Public Health Service Dental Category, April 2002. Council’s Choice Award, American Dental Association’s Council on Access, Prevention and Interprofessional Relations, 2002. Surgeon General’s Medallion, awarded by U.S. Surgeon General David Satcher, 2001. Fellow, American College of Dentists; elected 2001. Visiting Consultant, Ireland Fluoridation Forum, with presentations in Dublin and Cork, Ireland, 2001. Special Merit Award, American Association of Public Health Dentistry, 2001. Caswell A. Evans, Jr., D.D.S., M.P.H. 11 Visiting Consultant, British Fluoridation Society, London, England, with presentation at the British House of Parliament, 2000. Director’s Exemplary Service Award, National Institute of Dental and Craniofacial Research, NIH, 2000. Fellow, International College of Dentists; elected 2000. Special Recognition Award, National Dental Association, 2000. Distinguished Minority Visiting Professor, University of Boston Medical Campus, April 11-14, 2000; Association of Teachers of Preventive Medicine, and the Centers for Disease Control and Prevention. Certificate of Special Recognition, California Coalition for Childhood Immunization, 1995. Honorary Fellow, The Royal Society for Health, England (Hon FRSH); elected to membership1995 Champion of Prevention Award, Centers for Disease Control and Prevention, 1995. Distinguished Alumni Award, Columbia University School of Dental and Oral Surgery, 1994. Omicron Kappa Upsilon, National Honorary Dental Society, Epsilon Chapter; elected 1994. Award of Excellence, National Black Leadership Initiative on Cancer, 1993. Homer Calver Award, Environmental Health Section, American Public Health Association, 1993. Beverlee A. Myers Award for Excellence in Public Health, California State Department of Health Services, 1993; First Recipient. Institute of Medicine, National Academy of Science; elected to membership 1992. Public Health Leadership Institute, sponsored by the Centers for Disease Control and Prevention, 1991-92; Inaugural scholar class. Unit Commendation Award, Maternal and Child Oral Health Consultant Group, Health Resources and Services Administration, DHHS, 1991. President, Class of 1970, Columbia University School of Dentistry and Oral Surgery. LITERATURE AND PROPOSAL REVIEWS Journal of the American Dental Association Journal of the California Dental Association Journal of Healthcare for the Poor and Underserved Journal of Dental Education American Journal of Preventive Medicine International Medical Corps Institute of Medicine, National Academy of Sciences Josiah Macy, Jr. Foundation Journal of the American Public Health Association Journal of Health Communication Journal of Public Health Dentistry Journal of the American Medical Association, Pediatrics Journal of Adolescent Health Caswell A. Evans, Jr., D.D.S., M.P.H. 12 Frontiers in Public Health and Systems Research Health Affairs National Center on Minority Health and Health Disparities, National Institutes of Health National Institute of Dental and Craniofacial Research, National Institutes of Health Rapides Foundation Robert Wood Johnson Foundation W.K. Kellogg Foundation US Department of Health and Human Services; various agencies and bureaus Health Research Board, Ireland PUBLICATIONS AND PRESENTATIONS Available upon request. Attachment 3 Harold C. Slavkin HAROLD C. SLAVKIN CURRICULUM VITAE PERSONAL INFORMATION August 2014 Date of Birth: Place of Birth: Married: Children: Grandchildren Home Address: Telephone: Previous Employer: University of Southern California School of Dentistry (1968-2014) Center for Craniofacial Molecular Biology 2250 Alcazar Street, CSA #103 Los Angeles, CA 90033 Telephone: www.usc.edu/hsc/dental/ccmb HONORS AND AWARDS 2014 Formally appointed “Professor and Dean Emeritus” by the Provost of the University of Southern California Harold C. Slavkin 2014 Elected to the Board of Directors, LA Trust for Children’s Health for the Los Angeles Unified School Board (LAUSD) (the second largest public school district in USA with 650,000 children) 2012 FNIDCR “Distinction in Public Service Award” (in appreciation of a career devoted to excellence in dental research and education), Friends of the National Institute of Dental and Craniofacial Research, National Institutes of Health, December 6th 2012. 2012 Convocation Invited Speaker, International College of Dentists, October 2012 2011 Meskin/Shils Award, Dr. Edward B. Shils Entrepreneurial Fund, Annual Meeting, Union League of Philadelphia, October 18th 2011. 2010 Outstanding Dental Leader Award, International College of Dentists, Annual Meeting, October 8th 2010, Orlando, Florida 2009 ADA Gold Medal Award, American Dental Association 150th Annual Meeting, Honolulu, Hawaii 2008 Honorary Professorship, Peking University, Beijing, China 2008 Honorary Member, USC’s Chapter of Golden Key International 2006 William Gies Award, American College of Dentists 2006 Honorary Award, Hispanic Dental Association of Los Angeles 2004 Student Research Day Distinguished Scientist Award, NYU College of Dentistry 2004 Gruber Award, Greater New York Dental 2004 Pierre Fauchard Academy Honor Award 2002 Callahan Memorial Award, Ohio Dental Association 2001 Honorary Award, National Ectodermal Dysplasia Foundation 2001 Fellow, American Association for the Advancement of Science (AAAS) 2001 Honorary Award, American Cleft Lip and Palate Association 2001 Visiting CATCH Professorship, American Academy of Pediatrics 2001 John L. Sullivan Memorial Lecture, University of Tennessee, Knoxville 2001 Distinguished Award of the Swedish Dental Society 2000 “Prevention Research Advisory Council” Research America! Washington, DC 2000 Pierre Fauchard Gold Medal Award 2000 Honorary Doctor of Humane Letters Degree, University of Detroit Mercy 2000 Freddie Award for the film “Open Wide: Celebrating 50 years at the NIDR” International Health and Medical Film Competition, Time, Inc. (1999) 1999 Special Citation - American Dental Association 1999 Honorary membership, American Academy of Periodontology 1999 Honorary Doctor of Science Degree, University of Connecticut Health Science Center 1999 Honorary Doctor of Science Degree, University of Medicine and Dentistry of New Jersey 1999 Honorary Doctor of Science Degree, Université de Montréal 1999 Honorary Membership, the Craniofacial Society of Great Britain 1999 Honorary Membership, American Academy of Oral Medicine 1999 Paul Goldhaber Award, Harvard School of Dental Medicine 1999 Alvin Sakler Distinguished Lecture in Oral Medicine 1998 Honorary Member, British Society of Craniofacial Biology 1998 Henry Spenadel Award, 1st District Dental Society, New York 1998 Honorary Fellow, the Academy of Dentistry International 2 Harold C. Slavkin 1998 Percy T. Phillips Visiting Professorship 1997 Honorary Doctor of Science Degree, University of Maryland at Baltimore 1997 Vincent A. Barr Professorship, University of Kentucky School of Dentistry 1996 Annual William Thomas Green Morton Lectureship 1996 Alpha Omega International Dental Fraternity Achievement Medal 1996 Honoris Causa Award (Doctor of Philosophy) from the University Paris Vth 1996 18th Marvin Goldstein Lectureship, Medical College of Georgia 1995 Jerome M. & Dorothy Schweitzer Research Award, Greater New York Academy of Prosthodontics 1991 Honorary Chalmers Memorial Lectureship, American Society of Oral & Maxillofacial Surgeons 1991 Craniofacial Biology Award, International Association for Dental Research 1991 Dental Research Award, Columbia University 1990 Golden Key International Honor Society (Headquarters Atlanta, Georgia) 1990 Doctorate of Science (Honorary Degree), Georgetown University 1989 George and Mary Lou Boone Endowed Chair in Craniofacial Molecular Biology 1989 Keynote Address, American Cleft Palate-Craniofacial Association 1989 Pierre Fauchard Academy 1987 Lady Davis Visiting Professorship in Technion-Israel Institute of Technology's Rappaport Institute for Research in the Medical Sciences, Haifa, Israel 1987 Seymour Kreshover Memorial Lecture, National Institutes of Health 1980 Creative Scholarship Award, Associates of the University of Southern California 1980 Honorary Kisskaden Lecturer, American Association of Plastic Surgery 1979 Honorary Research Scholar, University College London, Gower Street, London 1976 Isaac Schour Memorial Award, International Association for Dental Research 1975 Honorary Lecturer, American Society of Plastic and Reconstructive Surgeons, Plastic Surgery Research Council 1974 Honorary Chalmers Memorial Lecture, American Society of Oral Surgeons 1972 Member, Omicron Kappa Upsilon 1968 Research Career Development Award, U.S. Public Health Service 1966 Member, Sigma Xi 1965 Postdoctoral Fellowship Award, U.S. Public Health Service 1965 Member, Tau Epsilon (Honorary Dental Group) 1965 Elected to Membership, Phi Delta Kappa (Honors), March 1st 1965 EDUCATION 2009-2010 Sabbatical, Center for Craniofacial Molecular Biology (CCMB), School of Dentistry, University of Southern California, Los Angeles, California (Professor Yang Chai) 3 Harold C. Slavkin 1987-1988 Sabbatical, Lady Davis Professor, School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (Professor Michael Silberman) 1979-1980 Sabbatical, Honorary Research Scholar, Department of Anatomy & Embryology, University College London, London (Professor Geoffrey Burnstock) 1975 Sabbatical, National Institute of Health, Bethesda, Maryland (George Martin, Laboratory for Developmental Biology, NIDR, NIH) 1966-1968 Postdoctoral Fellow, Department of Biochemistry, University of Southern California, Los Angeles (Professor Lucien Bavetta) 1965-1966 Postdoctoral Fellow, Department of Anatomy, School of Medicine, University of California, Los Angeles (Professor Richard Geulich) 1961-1965 School of Dentistry, University of Southern California, D.D.S., June, 1965, Honors 1958-1961 University of Southern California, B.A., English Literature, June, 1961, Honors LICENSURE State Licensure 1965 California Board of Dental Examiners #18411 National Licensure 1965 National Board of Dental Examiners American Dental Association PREVIOUS ACADEMIC/FEDERAL GOVERNMENT ADMINISTRATIVE / SCIENTIFIC ACTIVITIES January 2009 – December 31st 2009, Sabbatical Center for Craniofacial Molecular Biology The University of Southern California granted a one-year sabbatical. This time was used in several ways: (1) to retool in the science of craniofacial molecular biology with Professor Yang Chai and his research group [attending weekly research meetings, seminars and workshops, reading current scientific journals, reading and editing scientific manuscripts, coaching graduate 4 Harold C. Slavkin and postdoctoral students]; (2) to write and publish both scientific as well as health policy manuscripts in peer-reviewed journals [American Journal of Medical Genetics, Developmental Biology, Academic Pediatrics, Journal of American Dental Association]; (3) to take a number of courses in fiction writing and to use this background to write a novel entitled “Atlanta;” (4) to give a few invited lectures for Delta Dental of Idaho in Boise; (5) to continue participation within The Santa Fe Group and the conference held in Fort Lauderdale in November 2009; (6) to serve on the Board of Councilors for the Schools of Dental Medicine at Nova Southeastern University and University of Pittsburgh; (7) to continue advocacy for federal and state oral health programs for vulnerable children and elderly adults; (8) to continue to serve on the Board of Directors for Patterson Companies in Minneapolis; (9) to write a book entitled “Birth of a Discipline: Craniofacial Biology” to be published by Aegis Communications in Newtown, Pennsylvania, and (10) to participate in many activities with family and friends. January 2007 – October 2009 Project Advisor (along with Professor Caswell Evans) Gain collaborative foundation interest and financial support that enabled provision of counsel and guidance to quantify the extent of oral disease among underserved children throughout Los Angeles County. This study was led by Drs. Roseann Mulligan and Hazem Seirawan and resulted in the following publication: The Children’s Dental Health Project of Los Angeles County: The oral health baseline needs assessment of underpriviledged children. Supported by First 5 LA, The Annenberg Foundation, The California Endowment, and the California Wellness Foundation (released October 2009). August 2000 - December 2008 Dean, University of Southern California School of Dentistry Provide leadership as the chief academic and administrative officer of the School, reporting directly to the Provost of USC, and responsible for all academic and clinical programs, fiscal and human resource management, intra and inter-college relations and student, alumni, government and professional affairs. Introduced “White Coat Ceremony” in 2000 for entering freshman dental, dental hygiene and international dental students; strategic planning to emphasize measureable advances in education and learning, innovation and discovery, patient and community health programs, and leadership; introduced learner-centered education vis-à-vis problem-based learning (PBL) for the DDS Program; designed and created The USC Oral Health Center to enable faculty practice coupled with resident and student learning; enhanced Continuing Dental Professional Education from 1,000 to 8,000 learners per year; in 2006 aligned two trans-disciplinary academic programs into the School of Dentistry [i.e. Program in Biokinesiology & Physical Therapy (#1 rank in US News & World Report), and Program in Occupational Science & Occupational Therapy (#1 rank in US News & World Report]; sustained active research growth in craniofacial molecular biology, tissue engineering and oral infections and biofilms; grew community-based outreach programs through increased numbers of community-based clinics, hospitals and mobile clinics; enhanced communications and public relations to include many culturally diverse communities in Southern California; increased 5 Harold C. Slavkin percentage of graduating DDS seniors who apply and are accepted into Residency Programs; increased the value of the endowment ($45 million to $75 million); increased annual fundraising for Dentistry to $3.5 million per year; renovated essentially all student, resident and faculty practice clinics as well as waiting rooms and the Blair Learning Center rooms; introduced school-wide informatics as well as introduced Axium software for all patient/student clinic functions; and formalized collaborative agreements (e.g. faculty and student changes, research, continuing education) with Pacific Rim Institutions in Japan, Korea, Thailand, Taiwan, and China. 1995-2000 Director, National Institute of Dental and Craniofacial Research (Institute name change effective 10/98) Provided leadership, stewardship and management to realize the mission of the Institute--to promote health, reduce disease, improve diagnostics and therapeutics, and to encourage and foster fundamental research through inquiry and training programs. Served as the lead federal agency to create the first-time ever Surgeon General’s Report “Oral Health in America.” Provided leadership for the oral health components of “Healthy People 2000” and “Healthy People 2010” in the Department of Human Health Services. Provided leadership for the trans- NIH Pain Initiative, Head and Neck Cancer Initiatives, TMD Initiatives, Biomimetic/Bioengineering Initiatives and Diversity Initiatives. Led “first-time” strategic planning process “shaping the future,” increased patient advocacy groups, increased budget by an additional $120 million per year, increased leverage opportunities with other ICs, remodeled a number of research labs and dental clinic at NIDCR, created initiative to reduce oral health disparities, restructured extramural and intramural programs, chaired the trans-NIH committee for recruitment of a diverse workforce in biomedical research and authored the so-called “Slavkin Report,” created International Office for Oral Health, changed the name of the Institute from NIDR to NIDCR, and inspired the creation of “Friends of NIDCR” in 1998 (a patient, academic and industry advocacy group). 1995-2000 Chief, Craniofacial Development Section National Institute of Arthritis and Musculoskeletal and Skin Diseases This research program focused on molecular processes associated with specification of craniofacial, oral and dental patterns, and determination of cranial neural crest-derived cell lineages such as cartilage, bone and tooth formations. NIH COMMITTEES: 1999 Co-Chair, Trans-NIH Working Group on Domestic Health Disparities 1999 Acquisitions Management Steering Committee 1999 Central Services Office and Center (CSOC) Committee 1998 National Science and Technology Council (NSTC) Interagency Working Group (IWG) 6 Harold C. Slavkin 1998-1999 Chair, Committee for Recruitment of Ethnically Diverse Young Talent into Biomedical Research (i.e. “The Slavkin Report”) 1998-1999 Co-Chair, Implementation and Oversight Committee 1997-1999 Clinical Center Advisory Council Committee 1997 Co-Chair, NIH Pain Consortium 1996-97 Working Group on Priority Setting Committee 1996-97 NIH Scientist Administration Working Group 1996-97 Working Group on New Investigators 1989-1995 Director, Center for Craniofacial Molecular Biology, University of Southern California Conceptualized, designed, created and managed the Center for Craniofacial Molecular Biology (CCMB), a Research Organizational Unit located on the Health Sciences Campus dedicated to improving the diagnosis, treatment, therapeutics and prevention of human craniofacial malformations. The Center consists of 12 research faculty investigators and a total of approximately 60 full-time research staff, an operating budget of over $1 million dollars per year and a direct research budget of $5.5 million dollars annually. CCMB occupies 15,000 square feet of state-of-the-art research space designed by architect Kenneth Kornberg. 1975-1985 Chairman and Program Director, Graduate Program in Craniofacial Biology, Graduate School, University of Southern California Created and launched the first graduate program in Craniofacial Biology in the United States. Provided leadership and guidance for 10 years through NIH-supported training grants and non-federal support to augment the financial needs of the program. 1975-1976 Acting Laboratory Chief, Laboratory for Biology and Anomalies, Intramural Program, National Institute for Dental Research, National Institutes of Health, Bethesda, Maryland Provided scientific leadership and managed the Laboratory For Developmental Biology and Craniofacial Anomalies (LDB) within the Intramural Research Program of the NIDR on the NIH Campus in Bethesda. Evaluated ongoing research of approximately 60 NIH staff and served as acting Lab Chief for Dr. George Martin who was on sabbatical leave. Attended all planning meetings within the NIDR Intramural Research Program, participated in the NIH planning for recombinant DNA technology, and represented the LDB on the NIH Campus as required. 1973-1989 Laboratory Chief, Laboratory for Developmental Biology Gerontology Center, University of Southern California Directed and managed one of the five research laboratories of the Gerontology Center. As Lab Chief forged innovative scientific and training grant collaborations between faculty of the School of Dentistry and faculty of the College of Letters, Arts, and Sciences; responsible for recruiting 7 Harold C. Slavkin 12 new tenured-track basic science faculty for the School of Dentistry. In 1989, moved the research program from the Gerontology Center on the University Park Campus to the new Center For Craniofacial Molecular Biology on the Health Sciences Campus. 1969-1975 Chairman, Department of Biochemistry and Nutrition, School of Dentistry, University of Southern California Administered a rapidly changing Department of Biochemistry in the School of Dentistry. In six years, expanded Department from 5 faculty members, one graduate student and one postdoctoral fellow, with total NIH support of $160,000 per year in 1969, to12 full-time faculty, six graduate students, eight postdoctoral fellows, and NIH research and training support of $1.5 million dollars in 1975. During this tenure, organized and sponsored two major international research conferences (i.e. the 1992 and 1994 Santa Catalina Conferences). Appropriated significant expanded research space from 3,000 square feet in 1969, to 8,000 square feet in 1973. ACADEMIC AND RELATED APPOINTMENTS 2014-Present Professor and Dean Emeritus, University of Southern California (as designated by Provost of the University) 2011-Present Chairperson, Student Academic Performance Committee (SPPEC), Herman Ostrow School of Dentistry 2009-Present Professor of Dentistry, and Faculty, Center for Craniofacial Molecular Biology, Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California 2000-2009 USC School of Dentistry, and Endowed Chair, G. Donald and Marian James Montgomery Professor of Dentistry 1995-2000 Director, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 1990-1995 Endowed Chair, George and Mary Lou Boone Professor of Craniofacial Molecular Biology 1989-1995 Director, Center for Craniofacial Molecular Biology 1982-1995 Faculty, Thematic Option, College of Letters, Arts and Sciences, University of Southern California 8 Harold C. Slavkin 1975-1985 Chairman, Graduate Program in Craniofacial Biology, School of Dentistry, University of Southern California 1974-Present Professor of Biochemistry and Nutrition (Basic Sciences: Presently, Division of Health Promotion, Disease Prevention, and Epidemiology), School of Dentistry, University of Southern California 1971-1973 Associate Professor of Biochemistry and Nutrition (Basic Sciences), School of Dentistry, University of Southern California 1969 Faculty, Gerontology Institute, University of Southern California 1968-1970 Assistant Professor of Biochemistry and Nutrition (Basic Sciences), School of Dentistry, University of Southern California 1968-1995 Faculty, Graduate Programs in Cellular and Molecular Biology, Graduate School, University of Southern California RESEARCH, FELLOWSHIP, TRAINING AND CONFERENCE GRANTS Research Grants 2005-2010 Co-Principal Investigator, NIDCR, NIH, USPHS “The Molecular Regulatory Mechanism of Calvarial Morphogenesis (Yang Chai,PI) 1994-1995 Principal Investigator/Director. Center Grant: Center for Craniofacial Molecular Biology: U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE09165. $2,708,158 direct costs. (Center Principal Investigators: Drs. Harold C. Slavkin, Charles F. Shuler, Robert Maxson, Laurence H. Kedes, and Malcolm Snead) 1990-1995 Principal Investigator. Molecular Phenotype of Hertwig's Epithelial Root Sheath: U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE90002. $1,081,517 direct costs. Ten Year NIH Merit Award. 1991-1994 Co-Principal Investigator. Growth Factors and Lung Morphogenesis: U.S. Public Health Service, National Institutes of Health, National Institute of Heart and Lung Disease, HL-44977. $1,349,343.00 direct costs. Principal Investigator, Dr. David Warburton. 9 Harold C. Slavkin 1990-1995 Mentor/Sponsor. Epigenetic Growth Factors in Mandibular Morphogenesis: U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, Physician Scientist Award. Gilbert Mak, Scientist. $328,724 direct costs. 1991-1994 Principal Investigator. Program Project Grant: Biology & Chemistry of Mineralized Tissues: USPHS, NIH, NIDR DE-02848. $450,000/year direct costs. Co-Investigators: Fincham, MacDougall & Zeichner-David. 1989-1994 Principal Investigator/Director. Center Grant: Center for Craniofacial Molecular Biology: U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE-09165. $2,445,845 direct costs. (Center Principal Investigators: Drs. Harold C. Slavkin, Charles F. Shuler, Robert Maxson, Laurence H. Kedes, Eduardo Lau, Mary MacDougall and Malcolm Snead) 1989-1991 Principal Investigator. Biomatrix for Enhanced Guided Tissue Regeneration. Johnson and Johnson Dental Care Company. $50,000 direct costs. 1987-1993 Principal Investigator. Nutritional Studies of Tooth Development In Vitro. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE06425. $636,099 direct costs. (Research Associates: John Evans, Yasuyuki Sasano, Sasson Chitayat, C.C. Hu, Y. Sakakura.) 1991-1995 Principal Investigator. Program Project Grant: Biology of Connective Tissues, Bones and Teeth: US Public Health Service, National Institute for Dental Research, DE02848. $2,400,000 direct costs. (Co- Investigators: Drs. Alan Fincham, Margarita Zeichner-David and Mary MacDougall) 1986-1991 Principal Investigator. Program Project Grant: Biology of Connective Tissues, Bones and Teeth: U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE-02848. $2,144,272 direct costs. (Co-Investigators: Drs. Margarita Zeichner-David and Malcolm L. Snead) 1985-1991 Co-Principal Investigator. Determination and Expression of Amelogenin Gene Products. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research DE06988. $585,060 direct costs. (Principal Investigator: Dr. Malcolm Snead) 10 Harold C. Slavkin 1984-1988 Principal Investigator. Epithelial-Mesenchymal Interactions: Lung Development. U.S. Public Health Service, National Institutes of Health, National Heart, Lung, and Blood Institute. HL28325. $314,304 direct costs. (Co-Principal Investigators: Dr. Tina Jaskoll, 1984-1987; Dr. Peter Oliver, 1986-1988) 1984-1987 Principal Investigator. Nutritional Studies of Tooth Development In Vitro. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE06425. $262,075 direct costs. Co-Investigator, Dr. M.L. Snead 1983-1986 Principal Investigator. Isolation and Characterization of Enamel Gene Products. Johnson & Johnson Corporate Gifts, New Jersey. $75,000/yr. 1982-1986 Principal Investigator. Program Project Grant: $700,000 direct costs. (Co-Investigators: Drs. Margarita Zeichner-David and Mark Ferguson) 1981-1984 Principal Investigator. Epithelial-Mesenchymal Interactions: Lung Development. U.S. Public Health Service, National Institutes of Health, National Heart, Lung, and Blood Institute. HL28325. $186,575 direct costs.(Co-Principal Investigator: Dr. Lawrence Honig) 1980-1983 Co-Principal Investigator. H-2 and Teratogen Induced Craniofacial Malformation. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE05440. $538,267 direct costs. (Principal Investigator: Dr. Michael Melnick) 1977-1982 Principal Investigator. Program Project Grant: Program in Oral-Facial-Craniofacial Development Programs. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE02848. $1,397,217 direct costs. (Co-Investigators: Drs. Anna Brownell, Margarita Zeichner-David and Michael Melnick) 1977-1980 Principal Investigator. Intercellular Communication During Tooth Formation. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE05997. $243,369 direct costs. 1975-1977 Co-Principal Investigator. Role of Vascularization During Craniofacial Development. National Institutes of Health. Co-Principal Investigator with Dr. Nino Sorgente 1975-1977 Co-Principal Investigator. DNA-Chromosomal Protein in Craniofacial Development. National Institutes of Health. Co-Principal Investigator with Dr. Isaac Bekhor 11 Harold C. Slavkin 1975-1976 Co-Principal Investigator. Role of Cementogenesis. California Dental Association. $5,000. Co-Principal Investigator with Dr. Steven Schonfeld 1974-1977 Principal Investigator. Program Project Grant: Program in Oral-Facial-Craniofacial Development Programs. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE02848. $610,000 direct costs. (Co-Investigators: Drs. Paul Denny, Cedric Minkin, Gregory Mooser and Marcel Nimni) 1972-1978 Principal Investigator. Dermal-Epidermal Diffusion in Human Gingival Sulcus Tissues. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research. $275,000 direct costs. (Co-Investigators: Drs. Sigmund Stahl, Larry Yamada and John Chrispens) 1972-1977 Principal Investigator. Intercellular Communication During Tooth Formation. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE03569. $210,000 direct costs. (Co-Investigator: Dr. Gary Trump) 1969-1974 Principal Investigator. Program Project Grant: Biology of Connective Tissues, Bone and Teeth. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, DE02848. $676,925 direct costs. (Co-Investigators: Drs. Samuel Allerton, Lucien Bavetta, Jack Beierle, Barbara Mills, Marcel Nimni and Michael Schneir) 1969-1970 Principal Investigator. Time-Lapse Cinemicrophotography and Electron Microscopy of the Initiation of Tooth Formation. Southern California State Dental Association. $1,960 direct costs. 1968-1971 Principal Investigator/RCDA. Epithelio-Mesenchymal Interactions During Odontogenesis. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research. DE02768. $75,000 direct costs. (Co-Investigator: Dr. Lucien Bavetta) 1966-1968 Postdoctoral Fellow. Biochemical Studies on the Periodontium in Rat and Man. U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research. DE02471. $85,000 direct costs. Fellowships Grants Awarded and/or Sponsored 12 Harold C. Slavkin 1985-1990 Dr. Malcolm L. Snead, Research Career Development Award "Determination and Expression of Amelogenin Gene Products," 1985-1990, National Institutes of Health (Sponsor) 1980-1985 Dr. Michael Melnick, Research Career Development Award, "H-2 and Teratogen-Induced Craniofacial Malformations," 1980-1985, National Institutes of Health (Sponsor) 1975-1978 Dr. Anna Brownell, Postdoctoral Fellowship, "Fetal-Maternal Interactions and Craniofacial Development," 1975-1978, National Institutes of Health (Sponsor) 1974-1975 Dr. Richard Croissant, Postdoctoral Fellowship, "Model Studies of Tooth Development in Organ Culture," U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, 1974-1975 (Sponsor) Dr. Harold Guenther, Postdoctoral Fellowship, "Regulation of Extracellular Matrix Protein During Odontogenesis," 1974-1975, National Institutes of Health (Sponsor) Dr. Nino Sorgente, Postdoctoral Fellowship, "The Vasculature During Craniofacial Development," 1974-1975, National Institutes of Health (Sponsor) 1973-1977 Dr. Gregory Mooser, Research Career Development Award, "Molecular Biology of Taste Receptors," 1973-1977, National Institutes of Health (Sponsor) 1970-1975 Dr. Isaac Bekhor, Research Career Development Award, "Molecular Studies of Cell Differentiation in Mammalian Salivary Glands," 1970-1975, National Institutes of Health (Sponsor) 1968-1972 Awardee, Research Career Development Award, "Epithelial-Mesenchymal Interactions During Odontogenesis," U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, University of Southern California 1966-1968 Postdoctoral Fellow Trainee: "Training Grant in Biochemistry and Nutrition" (Dr. Lucien A. Bavetta, Program Director), U.S. Public Health Service, National Institutes of Health, National Institute for Dental Research, University of Southern California 13 Harold C. Slavkin 1965-1966 Postdoctoral Fellow Trainee: "Training in the Basic Sciences" (Dr. Richard C. Gruelich, Program Director) National Institutes of Health, National Institute for Dental Research, University of Southern California Training Grants 2011 – 2016 Faculty and Internal Advisory Group, Graduate Program in Craniofacial Biology (CBY), Training Grant from NIDCR, USPHS. 1991-1994 Principal Investigator, California Science Project (USC/LAUSD), University of California, Office of the President, $350,000, CSP/HS/91/92. 1992-1995 Principal Investigator, Praxis: USC/LAUSD Science Institute for Elementary School Teachers: National Science Foundation, $3,090,310, NSF TPE-9153819. 1969-1978 Principal Investigator, Training Grant in Biochemistry and Nutrition, National Institutes of Health, National Institute for Dental Research, DE00094. 1973-1975 Program Director, Multidisciplinary Postdoctoral Training in Craniofacial Developmental Biology, National Institutes of Health, National Institute for Dental Research, DE00134. 1975-1980, 1980-1985 Program Director, Training Program in Craniofacial Anomalies, National Institutes of Health, National Institute for Dental Research, DE07006. Conference Grants 1992 Conference on "Chemistry & Biology of Mineralized Tissues," February 5-9th, 1992, Hotel Del Coronado, Coronado, California, NIH, $20,000 and $50,000 raised from the Private Sector. 1989 Conference on "Advances in Craniofacial Developmental Biology and Clinical Implications." Funded by the March of Dimes Birth Defects Foundation, $10,000, San Francisco, April 1989. 1985 Conference on "Tissue Specific Expression of Cloned Genes." Funded by the National Institute of Child Health and Human Development, HD20793 for $17,000, August 1985 14 Harold C. Slavkin International Society of Developmental Biology (ISDB) Conference in Los Angeles, August, 1985. In addition to registration, funded by gifts and donations from the private sector, $250,000. 1974 Second Santa Catalina Island Colloquium: "Extracellular Matrix Influences on Gene Expression." Funded by the National Institute for Dental Research, DE04020-01 for $41,330, September 1974 1972 First Santa Catalina Island Colloquium: "Molecular Biology of Intracellular Matrices." Funded by the National Institute for Dental Research, DE03561-01 for $16,601, June 1972 TEACHING ACTIVITIES 2009-present Craniofacial Molecular Genetics (CBY 579L) (invited lectures) 2006 - present Fundamentals of Craniofacial Biotechnology (BME 499, 412) 2000- present Facilitator, PBL Cases (9 - 12 cases per year); and Triple-Jump Faculty 1989-1991 Project 2003: Science Education for Elementary School Teachers (CTSE 599) 1990-1995 Seminar in Cellular and Molecular Biology, College of Letters, Arts and Sciences (BISC537) 1985-1995 Mechanisms in Development (BioSci 518) 1982-1983 The Process of Change in Science (Core Course 103), Thematic Option, (Undergraduate Honors Students, College of Letters, Arts and Sciences) 1981-1995 Human Craniofacial Development, Undergraduate Program, School of Dentistry, (INTB 501) 1980-1995 Scientific Policy: Past, Present and Future (Graduate Students) (CBY 670) 1980-1991 Problems in Medical and Biomedical Ethics, School of Medicine, with Professor Wes Robb 1977 Recent Advances in Craniofacial Biology: The Macromolecular Structure and Function of Collagens with Associate Professor Michael Schneir (Graduate Students) 15 Harold C. Slavkin 1976-1995 Seminar Programs in Craniofacial Biology (CBY580) 1976-1995 Human Embryology and Craniofacial Development (Graduate Students in Graduate Program in Craniofacial Biology) (CBY 73) 1976-1991 Biomedical Ethics (Upper Division Undergraduates, Pre-med, and Pre-dental Students, College of Letters, Arts and Sciences) with Professor J. Wesley Robb 1974-1995 Research 490 Program (Advanced Upper Division Undergraduate Students in College of Letters, Arts and Sciences) 1974-1995 Principles of Developmental Biology (Graduate Students in Cellular and Molecular Biology Graduate Program) 1972-1995 Continuing Dental and Medical Education Courses in Oral Biology, Nutrition, Congenital Craniofacial Malformations, Immune Mechanisms in Periodontal Diseases, Growth and Development 1972 Recent Advances in Cellular and Molecular Biology: Intercellular Communication (Graduate Students in Cellular and Molecular Biology Graduate Program) 1972-1974 Core Course in Oral Biology (Residents in Dental Specialties) 1968-1995 Biochemistry of Human Disease and Nutrition (Dental Students) (BIOC 502) 1967-1985 Human Biochemistry and Nutrition (Dental Hygiene Students) (BIOC 310) UNIVERSITY COMMITTEES School of Dentistry (University of Southern California) 2011- 2014 Chair, Student Academic Performance and Ethics Committee (SPPEC) 2000-2008 Dean’s Council 2002-2008 Dean’s Kitchen Cabinet 2001-2008 Board of Councilors 1993-1995 Chair, Research Committee 16 Harold C. Slavkin 1992-1993 Chair, Orthodontic Chairman Search Committee 1989-1995 Grand Rounds Faculty Committee 1988-1995 Long-Range Planning Committee 1986-1988 Subcommittee of the PEW National Dental Education Program 1985-1987 Member, Faculty Grievance Committee 1977-1979 Member, Task Force, Developmental Dentistry 1974-1975 Member, Search Committee for Dean of the School of Dentistry 1973-1979 Chairman, Research Committee 1973-1974 Chairman, Priorities Committee 1970-1975 Member, Executive Committee 1968-1974 Chairman, Committee for Student Research 1968-1971 Member, Minority Recruitment Programs 1967-1979 Faculty Research Mentor, Undergraduate and Graduate University of Southern California 2007 Member, Clinical and Translational Science Institute, Internal Advisory Board 2007 Member, 15th Anniversary USC Institute for Genetic Medicine Honorary Committee 2005-2008 Member, Provost’s Research Council 2005-2008 Board Member, USC Neighborhood Outreach Program 2005 Member, Subcommittee on Federal Government Relations 2005 Member, Initiative on Global Presence Subcommittee 2005-2006 Chair, School of Gerontology Deans Search Committee 2004-2005 Chair, School of Pharmacy Deans Search Committee 2001-2008 Urban Deans Council 2004-2005 Member, Executive Advisory Committee to Provost 2000-2008 Member, Executive Council of Deans 2000-2008 Member, Council of Deans 2000-2001 Member, Executive Advisory Committee to Provost 2000-2004 Member, Capitol Improvements Committee 2000-2001 Chairman, Subcommittee on USC Capitol Projects in Science and Technology 1994-1995 Member, Honorary Degree Committee 1994 Member, Search Committee for Senior Vice President for Research 1993-1995 Chair, University Research Committee 1993-1995 Member, Social Science Research Institute Advisory Board 1991-1995 Member, Francisco Bravo Medical Magnet High School, Educational Committee 1991-1995 Member, Academic Senate Research Committee 1990-1995 Member, University Research Committee 1985-1989 Member, Health Sciences Caucus 1985-1988 Member, Academic Senate 17 Harold C. Slavkin 1984-1985 Member, Advisory Group to the Vice President of Health Sciences 1984-1985 Member, All-University Public Relations Committee 1980-1982 Member, Undergraduate Education Commission 1979-1980 Member, University Administration Committee 1979-1995 Member, Research Task Force 1977-1978 Member, Graduate School Review of Basic Sciences in School of Medicine 1975-1995 Member, Graduate Program in Craniofacial Biology 1974-1976 Member, Cancer Center Scientific Review Advisory Group Member, Academic Committee to the President 1973-1975 Member, Search Committee for Associate Director, Basic Sciences--Cancer Center 1973-1975 Member, All-University Curriculum Committee Member, University Task Force on the Gerontology Center 1969-1973 French Examiner, Graduate Programs in Biological Sciences MENTORING OF GRADUATE AND POSTDOCTORAL STUDENTS Postdoctoral Fellows 2004-2008 Randy Phillips, D.D.S. 2004-2013 Jennifer Holtzman, D.D.S. 2004-2008 Pascal Magne, D.D.S., Ph.D. 2001-2007 Hessam Nowzari, D.D.S., Ph.D. 1995-2000 Katsu Takahashi, D.D.S., Ph.D. 1995-2000 Ichiro Takahashi, D.D.S., Ph.D. 1995-2000 Jennifer Ayres, Ph.D. 1995-2000 Amano Yamane, Ph.D. 1993-1995 Osamu Amano, D.D.S., Ph.D. 1993-1995 Higinio Arzate, D.D.S., M.S., Ph.D. 1993-1995 Douglas Hoffman, M.D., Ph.D. 1993-1995 Hiroshi Sekiguichi, D.D.S., Ph.D. 1993-1995 Akira Yamane, D.D.S., M.S. 1991-1994 Yang Chai, D.D.S., Ph.D. 1991-1993 James Simmer, D.D.S., Ph.D. 1991-1993 Thomas Diekwisch, D.D.S., Ph.D. 1990-1992 Yasunori Sakakura, Ph.D. 1990-1993 Ching-Chun Hu, D.D.S., Ph.D. 1989-1991 Lillian Shum, Ph.D. 1988-1993 Gilbert Mak, D.D.S. 1988-1991 Sasson Chitayat, Ph.D. 1987-1990 Yasuyuki Sasano, D.D.S., Ph.D. 1986-1988 John Evans, D.D.S. 1985-1987 Masanori Nakamura, D.D.S., Ph.D. 18 Harold C. Slavkin 1984-1986 Supriya Mhaskar, Ph.D. 1984-1985 Martha Howard, Ph.D. 1984-1985 Randall Johnson, Ph.D. 1984-1985 Mary MacDougall, Ph.D. 1984 William Allen, III, D.D.S. 1983-1985 Mohamed Elkerdany, D.D.S., Ph.D. 1983-1984 Ming-Youn Hsu, D.D.S., Ph.D. 1982-1984 Jefferson Davis, D.D.S., M.D. 1982 Antonio Nanci, Ph.D. 1981-1984 Nelson Samuel, Ph.D. 1981-1984 Malcolm Snead, D.D.S., Ph.D. 1981-1983 Gary Greenberg, Ph.D. 1980-1983 Edward Graham, Ph.D. 1980-1981 Lawrence Honig, Ph.D. 1978-1979 Parmod Nijhawan, Ph.D. 1977-1980 Tina Jaskoll, Ph.D. 1977-1978 Ryu-Ichiro Hata, M.D. 1975-1977 Anna Brownell, Ph.D. 1975-1976 Victor Lee-Own, Ph.D. 1974-1975 Dennis-Duke Yamashita, D.D.S. 1974-1975 Harold Guenther, Ph.D. Candidates in Graduate Program, Cellular and Molecular Biology 1982 Elaine Cummings, Ph.D. 1976 Steven Schonfeld, D.D.S., Ph.D. 1975 Joseph Bonner, Ph.D. 1974 Richard Croissant, Ph.D. Ronald LeBaron, D.D.S., Ph.D. Visiting Scientists Sponsored 1997-2000 Kazuaki Nonaka, D.D.S., Ph.D. Department of Pediatric Dentistry Kyushu University, Fukuoko, Japan 1997-1998 Tsuyoshi Ikura, D.D.S., Ph.D. Department of Pharmacology Kyoto University, Kyoto, Japan 1996 Shogo Takashiba, D.D.S., Ph.D.Department of Periodontology & Endodontology Okayama University Dental School Okayama, Japan 19 Harold C. Slavkin 1996-1997 Ichiro Semba, D.D.S., Ph.D. Department of Oral Pathology Kagoshima University Dental School Ushki-cho, Sakuragaoka, Kagoshima, Japan 1996-1997 Osamu Tanaka, D.D.S., Ph.D. Department of Morphology Tokai University School of Medicine Bohseidai, Isehara-city Kanagawa-Pref, 259-11 Japan 1990-1992 Yasanori Sakakura, Ph.D. 1989 Koji Kindaichi, D.D.S., Ph.D., Department of Anatomy, School of Dentistry, University of Tohoku, Sendai, Japan 1988-1989 Shigeshi Kikunaga, Ph.D., Department of Food and Human Nutrition, Notre Dame Seishin University, Okayama, Japan 1986-1988 Wen Luo, M.D., Department of Oral Pathology, Medical College, Jinan University, Guangzhou, Guangdong, People's Republic of China 1985-1987 Masanori Nakamura, D.D.S., Ph.D., Department of Anatomy, School of Dentistry, Tohoku University, Sendai, Japan 1984-1985 Paul Ameloot (Doctorandus), Laboratory of Dentistry, Institute of Dentistry, Free University of Brussels, Brussels, Belgium 1981 Mark W.J. Ferguson, D.D.S., Ph.D., Department of Anatomy, Medical Biology Centre, The Queens University of Belfast, Northern Ireland 1978 Yael Michaeli, D.M.D., Hadassah Medical School, Hebrew University, Jerusalem, Israel 1977-1979 Marie Yamada, D.D.S., Ph.D., Department of Anatomy, School of Dentistry, Niigata University, Niigata, Japan 1976-1977 Michael Silbermann, D.D.S., Ph.D., 20 Harold C. Slavkin Department of Morphology, The Aba Khoushy School of Medicine, Haifa, Israel 1975 Guilherme Blumen, D.D.S., Department of Histology, School of Dentistry, Sao Paulo University, Sao Paulo, Brazil 1972-1974 Rolf Lehmann, Ph.D., Institute of Arthritis, University of Munster, Munster, Republic of West Germany 1972 Hector Orams, D.D.S., Ph.D., Department of Oral Medicine, School of Dental Medicine, University of Melbourne, Melbourne, Australia PROFESSIONAL ORGANIZATION MEMBERSHIPS American Dental Education Association Academy of Dentistry International American Academy of Periodontology American Association for Dental Research American Association for the Advancement of Science American Association of Anatomists American Association of University Professors American College of Dentists American Dental Association American Institutes of Biological Sciences American Society for Bone and Mineral Research American Society for Cell Biology American Society of Zoology Association of American Medical Colleges California Dental Association California Science Teachers Association Friends of the National Institute of Dental Craniofacial Research Greater Los Angeles Science Teachers Association International Association for Dental Research: . Craniofacial Biology Section . Mineralization and Calcification Group . Periodontal Research Group International Cleft Lip and Palate Society International College of Dentists International Society for Developmental Biology Institute of Medicine 21 Harold C. Slavkin Los Angeles Dental Society Los Angeles County Art Museum Associates New York Academy of Sciences Omicron Kappa Upsilon Sigma Xi Society of Craniofacial Genetics Society for Experimental Biology and Medicine The Santa Fe Group USC Dental Century Club USC Cancer Associates ACTIVITIES IN PROFESSIONAL ORGANIZATIONS 2014 Member, Board of Directors, Los Angeles Trust for Children’s Health 2011-present Chair, First Five Oral Health Committee, Los Angeles 2011-present Member, Oral Health Performance & Quality Committee, DentaQuest Institute, Washington DC 1996 – present Institute of Medicine (IOM) Member, Clinical Research Roundtable (2000 – 2005) Member, Reorganization of the NIH Committee (2005 – 2007) Member, Oral Health Initiative Committee (2010 – 2011) 2009 – 2012 American Dental Association Council on Scientific Affairs 2007 – 2008 Los Angeles Trust for Children’s Health Steering Committee 2005 – Present Member, Board of Directors, Scientific Advisory Board, National Children’s Oral Health Foundation 2001 – 2007 Harvard Medical School/Harvard School of Dental Medicine Visiting Committee 2001-2005 California Dental Association Foundation Board 2002 – 2008 University of Pittsburgh School of Dental Medicine 22 Harold C. Slavkin Board of Visitors 2008 – 2010 Nova Southeastern University, School of Dental Medicine Board of Councilors 2007 – present Operation Smile Scientific Council 2002 – 2011 National Ectodermal Dysplasia Foundation ` Director’s Council 1996 – Present Founding Member, Santa Fe Group International Association for Dental Research (IADR) 1994-97 Member, Task Force on General Session Subcommittee A, Meeting Content 1984-1987 Chairman, Progress in Research Committee 1983-1985 Representative to the AAAS Committee for Section G-Biological Sciences 1979-1980 Chairman, Isaac Schour Award Committee 1977-1981 Member, Isaac Schour Award Committee 1976-1994 Chairman, Progress of Research Committee 1976-1980 Councilor, Craniofacial Biology Section 1972-1979 Editor, Craniofacial Biology Newsletter 1970-1971 Councilor, Southern California Chapter 1969-1970 President, Southern California Chapter American Association for Dental Research (AADR) 1994-1995 Past President, AADR Board Member 1994-1995 Chairman, Research in Oral Biology Award 1994-1995 Member, AADR Distinguished Scientist Award Committee 1993-1994 President 1992-1993 President-Elect 1991 Vice President 1986 Member, Progress in Dental Research 1978-1979 Member, Nominating Committee 23 Harold C. Slavkin 1976-1977 Member, Board of Directors Councilor Representative 1975-1981 Councilor, Craniofacial Biology Section American Association for the Advancement of Science (AAAS) 2005-2009 & 1982-1985 Member, Dentistry (R) Section 1993-1995 & 1985-1988 Representative to the AADR Committee for Section G-Biological Sciences American Cleft Palate Association (ACPA) 1985-1995 Appointment on the Professional Education Committee American Dental Association (ADA) 2009-Present Member, Council on Scientific Affairs 1993 Member, Selection Committee for the Norton M. Ross Award for Excellence in Clinical Research 1985 Review ADA Research Programs 1982-1983 Chairperson, Organizing Committee, Symposium on Gerontology and Dentistry for the October, 1983 Annual ADA meeting, Anaheim, California American Society of Cell Biology (ASCB) 1990-1995 Member, Congressional Liaison Committee 1990-95 Member, Educational Programs Committee International Society of Developmental Biology (ISDB) 1985-1989 International Secretary 1982-1985 Chairperson, Organizing Committee for the 1985 International Meeting of ISDB COMMUNITY ACTIVITIES 1996-Present Founding Member, SANTA FE GROUP 2012 – 2015 Chairperson, Advisory Committee, First 5 and the Community Clinic Association of Los Angeles County (CCALAC), First 5 LA 24 Harold C. Slavkin 2014-Present Member, Board of Directors, LA TRUST 2003- 2008 Member, Advisory Board for Child Health Indicators Project 2002-Present Member, Board of Visitors, National Museum of Dentistry 2002-Present Independent Director, Member, Board of Directors, Patterson Companies ORGANIZATION OF CONFERENCES AND SYMPOSIA “Beyond Access to Care: The Role of Family and the Community,” Santa Fe Group, Organized by Wendy Mouradian and Harold Slavkin, Los Angeles, June 2006 “Major Revisions in Oral Health Professional Education,” Santa Fe Group, Organized by Dom DePalo and Harold Slavkin, San Francisco, June 2004 “Dental Enamel Conference.” April 26, 1996, The CIBA Foundation, London, England. Organized by Drs. Derek Chadwick & Harold Slavkin (Chairperson). "Chemistry & Biology of Mineralized Tissues." 4th International Conference, February 5-9, 1992, Hotel Del Coronado, California. Organized by Drs. Paul Price & Harold Slavkin "Advances in Craniofacial Developmental Biology and Clinical Implications." American Cleft Palate Association, April 23-24, 1989, San Francisco, California. Organized by Drs. Libby Wilson and H.C. Slavkin "Molecular Basis of Growth and Development." National Institute for Dental Research, Bethesda, Maryland, February 22-23, 1988. (Drs. Martin, Townsley and Slavkin) "Tissue Specific Expression of Cloned Genes." Funded by the National Institute of Child Health and Human Development, $17,000. August 9-12, 1985, Marina Del Rey, California. (Drs. Roger Pederson and Harold C. Slavkin) "New Discoveries and Technologies." Tenth International Congress of the International Society of Developmental Biologists. August 4-9, 1985, Los Angeles, California (Chair-person) Symposium: "Gerontology and Dentistry," Annual American Dental Association (ADA) Meeting, October 1983, Anaheim, California (Chairperson) Symposium: "Controversies in Modern Nutrition," Continuing Dental Education, School of Dentistry, University of Southern California, February 6-7, 1981 (Chairperson) 25 Harold C. Slavkin Symposium: "Nutrition and Preventative Dentistry," Continuing Dental Education, School of Dentistry, University of Southern California, February 28-March 1, 1980 (Chairperson) Symposium: "Vistas in Congenital Craniofacial Malformation," American Association for the Advancement of Science, San Francisco, January 3-8, 1980 (Chairperson) Symposium: "Aging, Oral Tissues and Periodontal Disease," 1975 American Society of Gerontology meetings in Louisville, Kentucky, October 26-30, 1975. (Drs. John Ingle, Roy Page, Ralph Snyderman and Harold C. Slavkin) Second Santa Catalina Island International Colloquium: "Extracellular Matrix Influences on Gene Expression," Fisherman's Cove, Two Harbours, Santa Catalina Island, California, September 1974 (Chairperson) Symposium: "Dental Plaque--Fact and Fancy," Syntax Research Division, Palo Alto, California (Drs. Richard Greulich, Harold L`e, S.S. Stahl, Sigmund Socransky, Max Listgarten, Joost Openheim and Harold C. Slavkin) First Santa Catalina Island International Colloquium: "Comparative Molecular Biology of Extracellular Matrices," Fisherman's Cove, Two Harbours, Santa Catalina Island, California, June 1972 (Chairperson) CONSULTANTSHIPS 2014-Present Member, Board of Directors, LA Trust 2012-2015 Chair, First 5 Committee for Reducing Oral Health Disparities in Los Angeles County 2012-Present Member, National Oral Health Quality Improvement Committee, DentaQuest Institute 2012-Present Member, Scientific Advisory Board, Developmental Biology and Regenerative Medicine Program, Childrens Hospital-Los Angeles 2001- Present Independent Director, Board of Directors, Patterson Companies, MN 2006-Present Member, Scientific Advisory Board, the National Children’s Dental Foundation 2007-Present Member, Scientific Advisory Group, Operation Smile, Virginia 2000-Present Member, Health Prevention Committee, Research America 2000-2003 Co-Chair, Clinical Research Workforce Committee, Panel on Clinical Research, Institute of Medicine, National Academy of Science. 1989 Chapman College, Division of Natural Sciences, Consultant. 1989 Deans' Distance Learning Consortium, New York University School Education, Working Group Member. 1985-1987 U.S. News and World Report, "Growth and Development." 1985-1987 Torstar Books, Inc., "The Human Body", Series Consultant. 26 Harold C. Slavkin 1984 Thrasher Research Foundation, Reviewer. 1983-1995 Los Angeles Educational Partnership-Science/Math Advisory Board. 1981-1985 Foundation for Craniofacial Deformities, International Advisory Council, Oral Biology and Medicine Study Section, National Institutes of Health, Chairperson. 1981-1982 An Evaluation and Assessment of the State of the Science: Congenital and Acquired Craniofacial Malformations, National Institute for Dental Research, National Institutes of Health (with Dr. Sam Pruzansky). 1980-1984 U.S. News and World Report, "Human Biology Series." 1976-1980, 1988-93 Board of Scientific Directors, National Institute for Dental Research, National Institutes of Health, Chairperson. 1976-1977 Institutional Fellowship Training Grant Committee, Chairman, National Institute for Dental Research, National Institutes of Health. 1973-1974 Craniofacial Anomalies Advisory Committee, National Institute for Dental Research, National Institutes of Health. 1975-1976 Biological Sciences, National Institute for Aging, National Institutes of Health. 1975-1976 Visiting Scientist, Intramural Program, National Institute for Dental Research, National Institutes of Health. 1974-1980 Bio-Basics International Corporation, New York. 1967-1973 Department of Biology, Los Angeles Valley College 1972-2000 Medical Research Council (MRC), Australia, Canada and Great Britain. 1973-1975 National Science Foundation (USA). 1973-Present National Foundation (March of Dimes), Ad Hoc Reviewer. 1967-Present National Institutes of Health, Consultation and Ad Hoc Site Visitor. EDITORIAL ACTIVITIES 2012-present Member, Editorial Advisory Board, Stem Cells in Oral Medicine 2009-Present Member, Honorary Editorial Board, Journal of Healthcare Leadership 2007-Present Associate Editor, Japanese Society of Prosthodontics 2007-Present Member, Editorial Board, Journal of Interdisciplinary Dentistry 2005-Present Member, Scientific Advisory Board, Idea International, Inc. 2004-Present Member, Editorial Board, Oral Sciences 2003-Present Member, Editorial Board, Dimensions in Dental Hygiene 2004-Present Member, Editorial Board, Revista Odontological Mexican 1997-2000 Member, Editorial Board, Surgeon General’s Report “Oral Health in America” 1995-1998 Member, Editorial Board, Oral Diseases 1990-2000 Member, Editorial Board, International Journal of Developmental Biology. 1989-1995 Member, Editorial Board, Current Opinion in Dentistry. 27 Harold C. Slavkin 1988-1995 Member, Scientific Advisory Board, California Museum of Science and Technology. 1987-1995 Member, National Advisory Panel, Modern Biology, Holt, Rinehart and Winston, Inc. 1984-1990 Board of Advisors, "INSEARCH." 1983-1995 Member, Los Angeles Educational Partnership, Math/Science Fellows Program. 1981-1995 Member, Editorial Board, Differentiation. 1981-1984 Member, Editorial Board, U.S. News and World Report. 1980-1981 Co-Managing Editor, United States, Differentiation. 1980-2000 Co-Editor, Journal of Craniofacial Genetics and Developmental Biology. 1979-1982 Member, Editorial Board, The Compendium on Continuing Education in General Dentistry. 1977-1995 Member, Editorial Advisory Board, Clinical Orthopedics and Related Research. 1976-1978 Member, Editorial Advisory Board, Journal of Dental Research. 1975-1995 Member, Southern California Advisory Group for Craniofacial Anomalies. 1973-1984 Member, Editorial Board, Oral Sciences Review. 1966-1977 Abstractor, Oral Research Abstracts, American Dental Association. Scientific Review, American Journal of Physiology Scientific Review, Archives of Oral Biology Scientific Review, Development Scientific Review, Developmental Biology Scientific Review, Calcified Tissue International Scientific Review, Proceedings of the National Academy of Sciences Scientific Review, Science Scientific Review, Journal of Cell Biology Scientific Review, Journal of Structural Biology Scientific Review, Oral Diseases PUBLISHED WORKS: Peer-Reviewed Scientific Contributions to Journals Saito K, Takahashi K, Asahara M, Kiso H, Togo Y, Tsukamoto H, Huang B, Sugai M, Shimizu A, Motokawa M, Economides AN, Slavkin HC, Besso K (2014) Interactions between BMP-7 28 Harold C. Slavkin and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations. PLOS ONE. Slavkin HC. (2014) From phenotype to genotype: enter genomics and transformation of primary health care around the world. J Dent Res. 93(6) (published online May 5th 2014 dol:10.1177/0022034514533569) Slavkin HC. (2014) Sex differences, gender biology, and chronic oral-facial pain, Dimensions in Dental Hygiene (May 24th 2014) Slavkin HC, Sanchez-Lara P, Chai Y, Urata M. (2014) A model for Interprofessional health care: lessons learned from craniofacial teams. Journal California Dental Assoc (September, 2014). Slavkin HC with Santa Fe Group (2014) Revising the scope of practice for oral health professionals: enter genomics. JADA 145(3):228-230. Slavkin, H.C. (2014) The Future of Research in Craniofacial Biology: Scientific Discovery Informs Oral Health Professional Education and Clinical Practices. In: Special Issue/Craniofacial Biology, edited by Grant Townsend, Australian Dental Journal. 59(1 Suppl):1-5. Slavkin, H.C. (2013) Reflections on My Journey in Biomedical Sciences: the Art, Science, and Politics of Advocacy. Discovery Section. J Dent Research. 92 (1):7-9. (online in November 2012) Slavkin, H.C. (2012) Year in Review. Inside Dentistry. 8(12):31. Slavkin, H.C. (2012) Advocate to improve American’s oral health. Dimensions in Oral Hygiene. 10(12):16-17. Slavkin, H.C. (2012) The Answer Lies in the Genome. Global Health NEXUS. 14:6-15. Slavkin, H.C. (2012) Enlightened Self-Interest and Public/Private Partnerships. J Public Health Dentistry 72:68-72. Slavkin, H.C. (2012) Professor Clifton O. Dummett: A Lifetime of Courage. J Dent Res. 91:117-118. 29 Harold C. Slavkin Slavkin, H.C. (2012) The evolution of the scientific basis for dentistry 1936 to now and its impact on dental education. Journal Dental Education. 76(1):28-35. Sakata, T., Takahashi, K., Kiso, H., Huang, B., Tsukamoto, H., Takemoto, M., Hayashi, T., Sugai, M., Nakamura, T., Yokota, Y., Shimizu, A., Slavkin, H.C., Bessho, K. (2012) Id2 controls chrondrogenesis acting downstream of BMP signaling during maxillary morphogenesis. Bone. 50(1):69-78. Slavkin, H.C., Fox, C., Meyer, D.M. (2011) Salivary diagnostics and its impact in dentistry, research, education and the professional community. Advances in Dental Research 23(4): 381-386. (online at www.adr.sagepub.com/content/23/4.toc). Nagata, M., Nuckolls, G.H., Wang, X., Shum, L., Seki, Y., Kawase, T., Takahashi, K., Nonaka, K., Takahashi, I., Noman, A.A., Suzuki, K., Slavkin, H.C. (2011) The primary site of the acrocephalic feature in Apert syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling. Bone 48(4):847-856. Slavkin, HC. (2011) The Future of Dentistry. Dear Doctor Magazine 5:32-38. Slavkin, HC. (2010) Leadership for Healthcare in the 21st Century: A Personal Perspective. Journal of Healthcare Leadership. 2:35-41 (on-line, open access journal) Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y.(2010) Transforming growth factor beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J. Biol. Chem.284:13987-14000. Slayton, RL and Slavkin, HC (2009) Commentary: Scientific investments continue to fuel improvements in oral health (May 2000 – Present). Academic Pediatrics. 9(6):383-385. Mouradian, WE, Slayton, RL, Maas, WR, Kleinman, DV, Slavkin, HC, DePaola, D, Evans, C and Wilentz, J. (2009) Progress in children’s oral health since the Surgeon General’s Report on Oral Health. Academic Pediatrics, 9(6):374-379. Huang, X., Bringas, P., Slavkin, H.C., Chai, Y. (2009) Fate of HERS during Tooth Root Development. Developmental Biology. 334 (1):22-30. Slavkin, H.C. (2009) What the Future Holds for Ectodermal Dysplasias: Future Research and Treatment Directions. American Journal of Medical Genetics. 149A:2071-2074. 30 Harold C. Slavkin Snead, M.L. and Slavkin, H.C. (2009) Science is the fuel for the engine of technology and clinical practice. Journal American Dental Association. 140 (Special Supplement):17-25. Shi S., Chai, Y. and Slavkin H.C. (2009) Emerging Opportunities for the Next Generation of Dental Implants? Dent. Today 28(3):98-99 http://www.dentistrytoday.com (posted March 15th, 2009). Murashima-Suginami A., Takahashi K., Sakata T., Tsukamoto H., Sugai M., Yanagita M., Shimizu A., Sakurai T., Slavkin H.C., Bessho K. (2008) Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun. 369(4):1012-6. Murashima-Suginami A., Takahashi K., Kawabata T., Sakata T., Tsukamoto H., Sugai M., Yanagita M., Shimizu A., Sakurai T., Slavkin H.C., Bessho K. (2007) Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun. 3;359(3):549-55. Slavkin H.C., Lawrence L. (2007) Incorporating leadership knowledge and skills into the dental education community. J Dent Educ. 71(6):708-12. Mouradian W.E., Huebner C.E., Ramos-Gomez F., Slavkin H.C. (2007) Beyond access: the role of family and community in children's oral health. J Dent Educ. 71(5):619-31. Slavkin, H.C. (2006) The future of dentistry. Interview with Harold C Slavkin, DDS. Dent Today. 25(10):90, 92. Slavkin, H.C., Bartold, P.M. (2006) Challenges and potential in tissue engineering. Periodontol 2000. 41:9-15. Slavkin, H.C. (2005). Dental Student Research: Helping to Shape the Future. Journal of the California Dental Association. 33(12):945. Sasaki, T., Ito, Y., Bringas, P. Jr., Chou, S., Urata, M.M., Slavkin, H.C., Chai, Y. (2005). TGFβ- Mediated FGF Signaling is Crucial for Regulating Cranial Neural Crest Cell Proliferation During Frontal Bone Development. Development. 133. Kupersmith, J., Sung, N., Myron, G., Slavkin, H., Califf, R., Bonow, R., Sherwood, L., Reame, N., Catanese, V., Baase, C., Feussner, J., Dobs, A., Tilson, H., Reece, A.E. (2005) Creating a New Structure for Research on Healthcare Effectiveness. J. of Investigative Medicine. 53(2):67- 72 Sasaki, T., Ito, Y., Xu, X., Han, J., Bringas, P. Jr., Maeda, T., Slavkin, H.C., Grosschedl, R., Chai, Y. (2005). LEF1 is a Critical Epithelial Survival Factor During Tooth Morphogenesis. Dev. Biol. 278:130-143. 31 Harold C. Slavkin DePaola, D., Slavkin, H.C. (2004). Reforming Dental Health Professions Education: A White Paper. J. Dental Education. 1139-1150. Crowley, W.F. Jr., Sherwood, L., Salber, P., Scheinberg, D., Slavkin, H., Tilson, H., Reece, E.A., Catanese, V., Johnson, S.B., Dobs, A., Genel, M., Korn, A., Reame, N., Bonow, R., Grebb, J., Rimoin, D. (2004). Clinical Research in the United States at a Crossroads: Proposal for a Novel Public –Private Partnership to Establish a National Clinical Research Enterprise. JAMA. 3;291(9):1120-6. Slavkin, H.C. (2004). Leadership in Research: Organizing Genius. Journal of the American College of Dentists. 71(4):33-8. Slavkin, H.C. (2003). Tissue Engineering: Modifying the Healing Response (Keynote Address). The International Journal of Oral & Maxillofacial Implants (JOMI). 18(5):760. Slavkin, H.C. (2003). The failure of Dentistry’s Social Contract with America and California’s Search for Legislative Solutions. Journal of Dental Education. 67(10):1076-7. Sung N., Crowley W., Genel M., Salber P., Sandy L., Sherwood L., Johnson S., Catanese V., Tilson H., Getz K., Larson E., Scheinberg D., Reece E., Slavkin H., Dobs A., Grebb J., Martinez R., Korn A., and Rimoin D. (2003). Central Challenges Facing the National Clinical Research Enterprise. JAMA. 289:1278-1287. Slavkin, H.C. (2003). Applications of Pharmacogenomics in General Dental Practice. Pharmacogenomics. 4(2):163-170. Yamane, A., Amano, O., Slavkin, H.C. (2003). Insulin-like Growth Factors, Hepatocyte Growth Factor and transforming Growth Factor-alpha in Mouse Tongue Myogenesis. Dev. Growth Differ. 45(1):1-6. Slavkin, H.C. (2003). Genomes, Biofilms, and Implications for Oral Health Professionals. Dimensions of Dental Hygiene. 1:16-20. Chai, Y, Slavkin, H.C. (2003). Prospects for Tooth Regeneration in the 21st Century: A Perspective. Microscopy Research and Technique (MRT). 60:469-479. Yamane, A., Amano, O., Slavkin, H.C. (2003) Insultin-like growth factors, hepatocyte growth factor and transforming growth factor-alpha in mouse tongue myogenesis. Dev Growth Differentiation 45(1):1-6. Slavkin, H.C. (2002). Distinguishing Mars From Venus: Emergence of Gender Biology Differences in Oral Health and Disease. Compendium. 23(10):29-31 32 Harold C. Slavkin Slavkin, H., Rossomando, E.F. (2002). JADA’s Industry Advisory Board. Journal of the American Dental Association. 133(6):696,698. Slavkin, H.C. (2002). The “Mouth-Body Connection” (Is There One?). FDA Consumer. 36(3):36. Slavkin, H.C. (2002). University of Southern California School of Dentistry: Dental Education for the 21st Century. Journal of the California Dental Association. 30:777-781. Slavkin, H.C. (2002). Implications of Pharmacogenomics in Oral Health. The Pharmacogenomics Journal. 2:148-151. Slavkin, H.C. et al (2002). YY1 Activates Msx2 Gene Independent of bone morphogenetic Protein Signaling. Nucleic Acid Research. 1;30(5):1213-23. Ignelzi, M.A. and Slavkin, H.C. (2002). Co-Culture of Osteoblasts with Immature Dural Cells Causes an Increased Rate and Degree of Osteoblast Differentiation (A Discussion). J. Plastic and Reconstructive Surgery. 109:643-644 Slavkin, H.C., (2001). Human Genome, Oral Infection/systemic Diseases and the Future of Clinical Dentistry. Annals of Dentistry. 5(1):12, 21. Ayres, J.A., Shum, L., Akarsu, A.N., Dashner, R., Takahashi, K., Ikura, T., Slavkin, H.C., Nuckolls, G.H. (2001). Msx2 is a Repressor of Chondrogenic Differentiation in Migratory Cranial Neural Crest Cells. Developmental Dynamics. 222(2):252-62. Ayres, J.A., Shum, L., Akarsu, N., Dasher, R., Takahashi, K., Ikura, T., Slavkin, H.C., and Nuckolls, G. (2001). DACH: Genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the murine homologue. Genomics. 77(1): 18-26. Slavkin, H.C. (2001). The Surgeon General’s Report and Special Needs Patient: A Framework for Action For Children and Their Caregivers. Special Care in Dentistry. 21(3): 88-94. Slavkin, H.C. (2001). Expanding the Boundaries: Enhancing Dentistry’s Contribution to Overall Health and Well-being. J. Dental Education. 65: 1323-1334. Goldhaber, P., Greenspan, J.S., Bowen, W.H., Genco, R.J., Barker, B., Greene, J.C., Allukian, M. Jr., McCallum, C.A., Slavkin, H. (2001). The Growing Family of NIH Institutes. Science. 8;292(5523):1835-6. Slavkin, H.C. (2001). The Human Genome, Implications for Oral Health and Diseases, and Dental Education. J. Dental Education. 65: 463-479. 33 Harold C. Slavkin Genco, R.J., Scannapieco, F.A., and Slavkin, H.C. (2000). Oral Reports. The Sciences. 40:25- 30. Slavkin, H.C. (2000). Thoughts on the Future of Dental and Craniofacial Research. Compendium. 21: 927-930. Slavkin, H.C., Baum B.J. (2000). Relationship of Dental and Oral Pathology to Systemic Illness. J of Amer. Med. Assoc. 284: 1215-1217. Slavkin, H.C. (2000). Toward Understanding the Molecular Basis of Craniofacial Growth and Development. Amer. J. of Orthodontics and Dentofacial Orthopedics. 117(5)538-539. Takahashi K, Shum L, Takahashi I, Nonaka K, Nagata M. Ikura T, Nuckolls G.H., and Slavkin, H.C. (2000). Mxs2 is a repressor of chondrogenic differentiation in migratory cranial neural crest cells. Develop. Biol. Slavkin, H.C. (2000). A Personal Change and a Changing Panorama: Looking Forward Toward the Next Decade. J. Amer. Dent. Assoc. 131:1071-1075. Slavkin, H.C. (2000). Maturity and Oral Health: Live Longer and Better. J. Amer. Dent. Assoc. 131:805-808. Slavkin, H.C. (2000). Obesity, Brain and Gonadal Function and Osteoporosis. J. Amer. Dent. Assoc. 131:673-677. Slavkin, H.C. (2000). From Discovery to Improving the Quality of Life. Compendium. 21(4):293-296. Semba I, Nonaka K. Takahashi I, Takahashi K, Dashner R, Shum L, Nuckolls G.H., and Slavkin, H.C. (2000). Positionally dependent chondrogenesis induced by MBP4 is co-regulated by Sox9 and MSX2. Develop. Dynamics. 217:401-414. Slavkin, H.C. (2000). Compassion, Communication and Craniofacial Orodental Trauma: Opportunities Abound. J. Amer. Dent. Assoc. 131:507-510. Slavkin, H.C. (2000). The Body’s Skin Frontier and the Challenges of Wound Healing: Keloids. J. Amer. Dent. Assoc. 131:362-365. Slavkin, H.C. (2000). Another Approach to Learning About Health Disparities: Working Toward Individualized Therapy. J. Amer. Dent. Assoc. 131:236240. Slavkin, H.C. (2000). Health Promotion Made Easy - Give a Gift!. J. Amer. Dent. Assoc. 131:87-91. 34 Harold C. Slavkin Nuckolls GH, Slavkin HC. (1999) Paths of glorious proteases. Nature Genetics. 23:378-380. Slavkin, H.C. (1999). Streptococcus Mutans, Early Childhood Caries, and New Opportunities. J. Amer. Dent. Assoc. 130:1787-1792. Slavkin, H.C. (1999). Building a Better Mousetrap: Towards an Understanding of Osteoporosis. J. Amer. Dent. Assoc. 130:16321636. Slavkin, H.C. (1999). Science and Technology Shapes the Future of Health. Commorative Millennium Publication, The Dental Society of the State of New York. Nonaka K, Shum L, Takahashi I, Takahashi K, Ikura T, Dashner R, Nuckolls G.H., Slavkin, H.C. (1999). Convergence of the BMP and EGF Signaling Pathways on Smad1 in the Regulation of Chrondrogenesis. Internat. J. of Develop. Biol. 43:795-807 Slavkin HC, Panagis JS, Kousvelari E. (1999) Future Opportunities for Bioengineering Research at the National Institutes of Health. Clin Orthop. 367:S17-30 Kobayashi S, Satomura K, Levsky J.M., Sreenath T, Wistow G.J., Semba I, Shum L, Slavkin HC, and Kulkarni A.B. (1999). Expression Pattern of Macrophage Migration Inhibitory Factor During Embryogenesis. Mechanisms of Development 84:153-156. Amano O, Bringas P Jr., Takahashi I, Takahashi K, Yamane A, Chai Y, Nuckolls GH, Shum L and Slavkin HC. (1999). Nerve Growth Factor (NGF) Supports Tooth Morphogenesis in Mouse First Branchial Arch Explants. Developmental Dynamics. 216:299-310 Slavkin, H.C. (1999) Toward molecular gastronomy, or what’s in a taste? J. Amer. Dent. Assoc. 130:1497-1500. Xu X, Li C, Takahashi K, Slavkin HC, Shum L, and Deng CX (1999). Murine Fibroblast Growth Factor Receptor 1α Isoforms Mediate Node Regression and Are Essential for Posterior Mesoderm Development. Developmental Biology. 208:293-306 Kobayashi S, Satomura K, Levsky JM, Sreenath T, Wistow GJ, Semba I, Shum L, Slavkin HC, Kulkarni AB. (1999) Expression pattern of macrophage migration inhibitory factor during embryogenesis. Mechanisms of Development. 84:153-156 Slavkin, H.C. (1999). Atherosclerosis, Russell Ross and the Passion of Science. J. Amer. Dent. Assoc. 130:1219-1222 Slavkin, H.C. (1999). Visual Illusions, Science and Esthetic Dentistry. J. Amer. Dent. Assoc. 130:1115-1119 35 Harold C. Slavkin Slavkin, H.C. (1999). The National Institute of Dental and Craniofacial Research: Behavioral Research as a Driver for Preventing Disease and Promoting Health. Psychological Science Agenda. 12(3):9 Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler C, Derynck R, and Werb Z. (1999). Epidermal Growth Factor Receptor Function is Necessary for Craniofacial Development and Palate Closure. Nature Genetics. 22:69-73. Slavkin, H.C. (1999) Learning, Immunology and Allergic Responses. J. Amer. Dent. Assoc. 130:863-867 Slavkin H.C. (1999) Towards a Common Theme for Autoimmunity. J. Amer. Dent. Assoc. 130:561-566 Slavkin H.C. (1999) Changing Patterns of Disease and Mucosal Immunity. J. Amer. Dent. Assoc. 130:735-738 Slavkin H.C. (1999) Entering the Era of Molecular Dentistry. J. Amer. Dent. Assoc. 130:413- 417. Slavkin H.C. (1999) The Significance of a Human Smile: Observations on Bell’s Palsy. J. Amer. Dent. Assoc. 130:269-272. Slavkin H.C. (1999) Does the Mouth Put the Heart at Risk? J. Amer. Dent. Assoc. 130:109-113. Nuckolls G.H., Shum L., Slavkin H.C. (1999) Progress Towards Understanding Craniofacial Malformations. The Cleft Palate Craniofacial Journal. 36(1)12-26. Takahashi K, Yamane A, Bringas P, Jr., Caton J , Slavkin, H.C., Zeichner-David M. (1998) Induction of Amelogenin and Ameloblastin by Insulin and Insulin-like Growth Factors (IGF-I and IGF-II) During Embryonic Mouse Tooth Development In Vitro. Connec. Tissue Res. 39(1- 3):269-278 Slavkin H.C. (Dec. 1998) Science Technology and Health Literacy for the 21st Century–A Future for Dentistry. New York State Dental Journal. 64(10):25-28. Slavkin H.C. (Oct. 1998) The Future of Clinical Dentistry. Journal of Dental Education. 751-755 Chai Y, Bringas P Jr., Shuler CF, Slavkin HC. (1998) PDGF-A and PDGFR-α Regulate Tooth Formation via Autocrine Mechanism During Mandibular Morphogenesis in Vitro. Developmental Dynamics. 213:500-511 Slavkin H.C. (1998) Facing the New Century with the National Institute of Dental and Craniofacial Research. J. Amer. Dent. Assoc. 129:1760-1763. 36 Harold C. Slavkin Slavkin, H.C. (1998) Diseases and Disorders that Open a Seam Between the Face and the Self. J. Amer. Dent. Assoc. 129:1608-1611. Slavkin, H.C. (1998) Cell Biology, Disease Susceptibility and Innovative Therapeutics. J. Amer. Dent. Assoc. 129:1462-1466. Takahashi I, Nuckolls GH, Takahashi K, Tanaka O, Semba I, Dashner R, Shum L, and Slavkin HC. (1998) Compressive Force Induces Sox9, Type II Collagen and Aggrecan and Inhibits IL1-β Expression Resulting in Chondrogenesis in Mouse Embryonic Limb Bud Mesenchymal Cells. J. Cell Sci. 111:2067-2076. Yamane A, Bringas P Jr., Mayo ML, Amano O, Takahashi K, Shum L, and Slakin HC. (1998) Transforming Growth Factor Alpha Up-regulates Desmin Expression During Embryonic Tongue Morphogenesis. Developmental Dynamics. 213:71-81. Slavkin H.C. (1998) Building a Dynamic Picture of the Dental and Craniofacial Complex: Progress in Imaging. J. Amer. Dent. Assoc. 129:1301-1306 Slavkin H.C. (1998) Toward Molecularly Based Diagnostics for the Oral Cavity. J. Amer. Dent. Assoc. 129:1138-1143 Yamane A, Takahashi K, Mayo M, Vo H, Shum L, Zeichner-David M, Slavkin H.C. (1998) Induced Expression of MyoD, Myogenin and Desmin During Myoblast Differentiation in Embryonic Mouse tongue Development. Archives of Oral Biol. 43:407-416 Slavkin, H.C. (1998) Protecting the Mouth Against Microbial Infections. J. Amer. Dent. Assoc. 129:1025-1030 Slavkin, H.C. (1998) Advice to Coaches of Students in One of the Youngest Sciences. J. Dent. Education. 62(3):226-229 Takahashi K, Nuckolls G, Tanaka O, Semba I, Takahashi I, Dashner R, Shum L, Slavkin, H.C. (1998) Adenovirus Mediated Ectopic Expression of Mxs2 in Even-Numbered Rhombomeres Induces Apoptotic elimination of Cranial Neural Crest Cells in Ovo. Development. 125:1627- 1635 Slavkin, H.C. (1998) And We All Lived Happily Ever After: Understanding the Biological Controls of Aging. J. Amer. Dent. Assoc. 129:629-633 Slavkin, H.C. (1998) NIDR: 50 Years of Scientific Progress. CDA Journal. 26(6):440-444 Slavkin, H.C. (1998) Building Sound and Regular Teeth: The National Institute of Dental Research Celebates Its Golden Anniversary. J. Amer. Dent. Assoc. 129:694-701 37 Harold C. Slavkin Slavkin, H.C. (1998) Toward Increased Sensitivity and Specificity in the Treatment of Neoplastic Disease. J Amer. Dent. Assoc. 129:473-478 Chai Y, Bringas P, Jr., Shuler C, Devaney E, Grosschedl R, Slavkin, H.C. (1998) A Mouse Mandibular Culture Model Permits the Study of Neural Crest Cell Migration and Tooth Development. Inter. J. Develop. Biol. 42:87-94 Slavkin, H.C. (1998) Distinguishing Mars from Venus: Emergence of Gender Biology in Health and Disease. J. Amer. Dent. Assoc. 129:357-360 Slavkin, H.C. (1998) Biomimicry, Dental Implants and Clinical Trials. J. Amer. Dent. Assoc. 129:226-230 Slavkin, H.C. (1998) Placing Health Promotion into the Context of Our Lives. J. Amer. Dent. Assoc. 129:91-95 Sadler TW, Melissa R, Slavkin HC, Lauder J, Maness P, Linney E, Sulik K, Mirkes P (1997) Growth and Differentiation Factors. Reproductive Toxicology 11(2-3):331-337 Slavkin HC. (1997) Preparing for the 21st century: a new era for oral health promotion and oral health care. J Dent Assoc S. Afr 52(1):2-3 Slavkin HC. (1997) Preparing for the 21st century: a new era for oral health promotion and oral health care. International College of Dentists Globe. pp. 15-18 Yamane A, Takahashi K, Bringas P. Jr., Amano O, Slavkin H.C., Zeichner-David M. (1997) Insulin-like Growth Factor-I and II Induce an Increase in the Translational Activity of Amelogenin in the Mouse Embryonic First Molar In Vitro. Int. J of OralBiol. 22(3):161-166 Yamane A., Mayo M.L., Bringas P. Jr., Chen L., Huynh M., Thai, K., Shum, L., Slavkin, H.C. (1997) TGF-α, EGF and Their Cognate EGF Receptor Are Co-Expressed with Desmin During Embryonic, Fetal and Neonatal Myogenesis in Mouse Tongue Development. Developmental Dynamics 209:353-366 Slavkin, H.C. (1997) Reflections on Taste for Oral Health Professionals. J. Amer. Dent. Assoc. 128:1697-1701 Slavkin, H.C. (1997) Chronic Disabling Diseases and Disorders: The Challenges of Fibromyalgia. J. Amer. Dent. Assoc. 128:1583-1589 Slavkin, H.C. (1997) Benefit-to-Risk Ration: The Challenge of Antibiotic Drug Resistance. J. Amer. Dent. Assoc. 128:1447-1451 38 Harold C. Slavkin Slavkin, H.C. (1997) Nutrients and Micronutrients: Progress in Science-Based Understanding. J. Amer. Dent. Assoc. 128:1306-1313 Slavkin, H.C. (1997) Benefits and Risks of Medications: Challenges for the 21st Century. J. Amer. Dent. Assoc. 128:1157-1160 Slavkin, H.C. (1997) Sex, Enamel & Forensic Dentistry: A Search for Identity. J. Amer. Dent. Assoc. 128:1021-1025 Slavkin, H.C. (1997) First Encounters: Transmission of Infectious Oral Diseases from Mother to Child. J. Amer. Dent. Assoc. 128:773-778. Slavkin, H.C. (1997) Clinical Dentistry in the 21st Century. Compendium 18(3)212-218 Zeichner-David M, Vo H, Tan H, Diekwisch T, Berman B, Thiemann F, Alocer MD, Hsu P, Wang T, Eyna J, Caton J, Slavkin HC, MacDougall M. (1997) Timing of the Expression of Enamel Gene Products During Mouse Tooth Development. Int. J Dev Biol 40:27-38 Chai Y, Sasano Y, Bringas P Jr., Mayo M, Slavkin H.C., Shuler, C. (1997) Characterization of the Fate of Medial Epithelial Cells During the Fusion of Mandibular Prominances in Mice Lacking TGFβ. Developmental Dynamics 208:526-535 Slavkin, H.C. (1997) Diabetes, Clinical Dentistry and Changing Paradigms. J. Amer. Dent. Assoc. 128:638-644 Slavkin, H.C. (1997) Biofilms, Microbial Ecology & Antoni van Leeuwenhoek. J. Amer. Dent. Assoc. 128:492-495 Slavkin, H.C. (1997) What’s in a Tooth. J. Amer. Dent. Assoc. 128:366-369 Slavkin, H.C. (1997) Charles Darwin and the Foundation of Clinical Genetics in Dentistry. J. Amer. Dent. Assoc. 128:241-245 Slavkin, H.C. (1997) Emerging & Re-emerging Infectious Diseases: A Biological Evolutionary Drama. J. Amer. Dent. Assoc 128:108-113 Zhao J, Bu D, Lee M, Slavkin HC, Hall FL, Warburton D (1996) Abrogation of Transforming Growth Factor-β Type II Receptor Stimulates Embryonic Mouse Lung Branching Morphogenesis in Culture. Developmental Biology 180:242-257 Slavkin, H.C. (1996) Basic Science is the Fuel that Drives the Engine of Biotechnology: A Personal Science Transfer Vision for the 21st Century. Tech & Health Care 4. 249-253 39 Harold C. Slavkin Slavkin, H.C. (1996) And the Next Fifty Years? The Future of Recombinant DNA Technology in Oral Medicine. J. Public Health Dentistry. 278-285 Hoffman, D.S., Bringas P. Jr., Slavkin, H.C. (1996) Co-culture of Contiguous Developmental Fields in a Serumless, Chemically-Defined Medium: An In Vitro Model Permissive for Development of the Mouse Ear. Int. J. of Dev. Biol 40:953-964 Slavkin, H.C. (1996) The Flu Zone. J. Amer. Dent. Assoc. 127:127-129 Slavkin, H.C. (1996) Understanding Human Genetics J. Amer. Dent. Assoc. 127:266-267 Slavkin, H.C. (1996) Are We Ready for Clinical Gene Therapy. J. Amer. Dent. Assoc. 127:396- 297 Slavkin, H.C. (1996) The War on Oral Cavity and Pharyngeal Cancer. J. Amer. Dent. Assoc. 127:517-520 Slavkin, H.C. (1996) Meeting the Challenges in Craniofacial-Oral-Dental Birth Defects. J. Amer. Dent. Assoc. 127:681-682 Slavkin, H.C. (1996) Notes on a Silent Disease. J. Amer. Dent. Assoc. 127:801-802 Slavkin, H.C. (1996) A Lifetime of Motion: Temporomandibular Joints. J. Amer. Dent. Assoc. 127:1093-1098 Slavkin, H.C. (1996) Biomimetics: Replacing Body Parts is no Longer Science Fiction J Amer. Dent. Assoc. 127:1254-1257 Slavkin, H.C. (1996) An Update on HIV/AIDS. J. Amer. Dent. Assoc. 127:1401-1404 Slavkin, H.C. (1996) What We Know About Pain. J. Amer. Dent. Assoc. 127:1536-1541 Slavkin, H.C. (1996) The A, B, C, D, & E of Viral Hepatitis. J. Amer. Dent. Assoc. 127:1667- 1670 Slavkin, H.C. (1996) Infection and Immunity. J. Amer. Dent. Assoc. 127:1792-1796 Slavkin, H.C. (1996) Director's Column. Neuroscience Newsletter pp. 10,17 (May/June) Wuenschell, C.W., Sunday, M.E., Singh, G., Minoo, P., Slavkin, H.C., Warburton, D. (1996) Embryonic Mouse Lung Epithelial Progenitor Cells Co-Express Immunohistochemical Makers of Diverse Mature Cell Lineages. The J of Histochem & Cytochem 44(2):113-123 Slavkin, H.C., Diekwisch, T. (1996) Evolution in Tooth Developmental Biology: Of Morphology and Molecules. The Anatomical Record 245:131-150 40 Harold C. Slavkin Slavkin, H.C. (1996) Linking Research and Practice. J. of the Amer. Coll. Of Dentists: Dentistry 2010: Visions of the Future 63(3):21-22 Hu, J.C.C., Zhang, C., Slavkin, H.C. (1995) The Role of Platelet-Derived Growth Factor in the Development of Mouse Molars. Int. J. Dev. Biol 39:939-945 Slavkin, H.C. (1995) Molecular biology experimental strategies for craniofacial-oral-dental dysmorphology. Connective Tiss. Res. 32:233-239. Fincham, A.G., Moradian-Oldak, J., Diekwisch, T.G.H., Lyaruu, D.M., Wright, J.T., Brigas, Jr., P. and Slavkin, H.C. (1995) Evidence for amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. J. of Struct. Biol. 115:1-10. Moradian-Oldak, J., Simmer, J.P., Lau, E.C., Diekwisch, T., Slavkin, H.C. and Fincham, A.G. (1995) A review of the aggregation properties of a recombinant amelogenin. Connective Tissue Research, 31, [No. 3]:1-6. Diekwisch, T.G.H., Berman, B.J., Gentner, S. and Slavkin, H.C. (1995) Initial enamel crystals are not spatially associated with mineralized dentine. Cell Tissue Res. 279:149-167. Zeichner-David, M., Diekwisch, T., Fincham, A. Lau, E., MacDougall, M., Moradian-Oldak, J., Simmer, J., Snead, M. and Slavkin, H.C. (1995) Control of ameloblast differentiation. Int. J. Dev. Biol. 39:69-92. MacDougall, M., Zeichner-David, M., Crall, M., Yen, S., Vides, J. and Slavkin, H.C. (1994) Presence of dentine phosphoprotein in molars of a patient with dentinogenesis imperfecta type II. J. Craniofac. Genet. Develop. Biol. 14:26-32. Chai, Y., Mah, A., Crohin, C., Groff, S., Bringas, P., Le, T., Santos, V. and Slavkin, H. C. (1994) Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Develop. Biol. 162:85-103. Simmer, J.P., Hu, C.C., Lau, E.C., Slavkin, H.C. and Fincham, A.G. (1994) Alternative splicing of the mouse amelogenin primary RNA transcript. Calcif. Tiss. Internat. 55:302-310. Fincham, A.G., Moradian-Oldak, J., Simmer, J.P., Sarte, P.E., Lau, E.C., Diekwisch, T. and Slavkin, H.C. (1994) Self-assembly of a recombinant amelogenin protein generates supramolecular aggregates, J. Struct. Biol. 112, 103-109. Nakamura, M., Bringas, Jr., P., Nanci, A., Zeichner-David, M., Ashdown, B. and Slavkin, H.C. (1994) Translocation of enamel proteins from inner enamel epithelia to odontoblasts during mouse tooth development. The Anatomical Record 238:383-396. 41 Harold C. Slavkin Simmer, P.J., Lau, E.C., Hu, C., Aoba, T., Lacey, M., Nelson, D., Zeichner-David, M., Snead, M.L., Slavkin, H.C. and Fincham, A.G. (1994) Isolation and characterization of a mouse amelogenin expressed in Eschericia coli. Calcif. Tiss. Internat. 54:312-316. Canoun, C., Ma, C., Halpern, D., Shum, L., Bringas, P., Sank, A. and Slavkin, H. C. (1993) Endogenous epidermal growth factor regulates limb development. J. Surg. Res. 54:638-647. Diekwisch, T., David, S., Bringas, P., Santos, V. and Slavkin, H.C. (1993) Antisense inhibition of AMEL demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development. Development, 117, 471-482. Lau, E.C., Li, Z.-Q., Santos, V. and Slavkin, H.C. (1993) Messenger RNA phenotyping for semi- quantitative comparison of glucocorticoid receptor transcript levels in the developing embryonic mouse palate. J. Steroid Biochem. Mol. Biol. 46:751-758. Lau, E.C., Li, Z.-Q. and Slavkin, H.C. (1993) Preparation of denatured plasmid templated for PCR amplification. BioTechniques,14:378. Seth, R., Shum, L., Wu, F., Wuenschell, C., Hall, F.L., Slavkin, H.C. and Warburton, D. (1993) Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy. Develop. Biol. 158:555-559. Shum, L., Sakakura, Y., Bringas, Jr., P., Luo, W., Snead, M. L., Mayo, M., Crohin, C., Millar, S., Werb, Z., Buckley, S., Hall, F.L., Warburton, D. and Slavkin, H.C. (1993) EGF abrogation induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. Development, 118:903-917. Slavkin, H.C. (1993) Reigers syndrome revisited: experimental approaches using pharmocologic and antisense strategies to abrogate EGF and TGF-a functions resulting in dysmorphogenesis during embryonic mouse craniofacial morphogenesis. Am. J. of Med. Genetics, 47:689-697. Canoun, C., Ma, C., Halpern, D., Shum, L., Bringas, Jr., P., Sank, A. and Slavkin, H.C. (1993) Endogenous epidermal growth factor regulates limb development. J. of Sur. Res. 54:638-647. Gollard, R.P., Slavkin, H.C. and Snead, M.L. (1992) Polyoma virus-induced murine odontogenic tumors. Oral Surg., Oral Med. & Oral Path. 74:761-767. Hu, C.C., Sakakura, Y., Sasano, Y., Shum, L., Bringas, P., Werb, Z. and Slavkin, H.C. (1992) Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis. Int. J. Dev. Biol. 36: 505-516. 42 Harold C. Slavkin Lau, E.C., Simmer, J.P., Bringas, Jr., P., Hsu, D.D.-J., Hu, C.-C., Zeichner-David, M., Thiemann, F., Snead, M.L., Slavkin, H.C. and Fincham, A.G. (1992) Alternative splicing of the mouse amelogenin primary RNA transcript contributes to amelogenin heterogeneity. Biochem. Biophys Res. Commun. 188:3 1253-1260. MacDougall, M. Slavkin, H.C. and Zeichner-David, M. (1992) Characteristics of Phosphorylated and non-phosphorylated dentine phosphoprotein. Biochem. J. 287:651-655. MacDougall, M., Zeichner-David, M., Murray, J., Crall, M., Davis, A. and Slavkin, H.C. (1992) Dentin phosphoprotein gene locus in not associated with dentinogenesis imperfecta Type II and III. Am. J. Human Genetics, 50:190-194. Mayo, M.L., Bringas, P., Santos, V., Shum, L. and Slavkin, H.C. (1992) Desmin expression during early mouse tongue morphogenesis. Internat. J. Devleop. Biol. 36:255-263. Sasano, Y., Kaji, Y., Nakamura, M., Kindaichi, K., Slavkin, H.C. and Kagayama, M. (1992) Distribution of glycoconjugates localized by peanut and maclura pomifera agglutinis during mouse molar root development. Acta Anatomica, 145:149-155. Sasano, Y., Mizoguchi, I., Kagayama, M., Shum, L., Bringas, Jr., P. and Slavkin, H.C. (1992) Distribution of type I collagen, type II collagen and PNA binding glycoconjugates during chondrogenesis of three distinct embryonic cartilages. Anat. Embryol. 186:205-213. Slavkin, H.C. (1992) Incidence of cleft lips, palates rising. J. Amer. Dent. Assoc.123:61-65. Slavkin, H.C. (1992) Regulatory factors in pulp biology: a reaction. Proc. Finn. Dent. Soc. 88 Suppl. I, 377-380. Warburton, D., Seth, R., Shum, L., Horcher, P.G., Hall, F.L., Werb, Z. and Slavkin H.C. (1992) Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morhogenesis. Developmental Biol. 149:123-133. Zeichner-David, M., MacDougall, M., Yen, S., Hall, F., and Slavkin, H.C. (1992) Protein kinases in dentinogenesis. Proc Finn Dent Soc 88 Suppl. I, 295-303. Fincham, A.G., Bessem, C.C., Lau, E.C., Pavlova, Z., Shuler, C.F., Slavkin, H.C. and Snead, M.L. (1991) Human developing enamel proteins exhibit sex-linked dimorphism. Calcif. Tiss. Internat. 48:288-290. Fincham, A.G., Hu, Y., Lau, E.C., Slavkin, H.C. and Snead, M.L. (1991) Amelogenin post-secretory processing in the postnatal mouse molar tooth. Arch Oral Biol. 36:305-317. 43 Harold C. Slavkin Kresja, R.J., Bringas, Jr., P. and Slavkin, H.C. (1991). A neontological interpretation of conodont elements based on agnathan cyclostome tooth structure. Lethaia, 23:359-378. Kresja, R.J., Bringas, Jr., P. and Slavkin, H.C. (1991). The cyclostome model: an interpretation of conodont element structure and function based on cyclostome tooth morphology, function and life history. Cour-Forsch - Inst Senckenberg, 118:473-492. Luo, W., Slavkin, H.C. and Snead, M.L. (1991). Cells from Hertwig's epithelial root sheath do not transcribe amelogenin. J. Periodont Res. 26:42-47. MacDougall, M., Zeichner-David, M., Murray, J., Crall, M., Davis, A. and Slavkin, H.C. (1991) Dentine phosphoprotein gene locus is not associated with dentinogenesis imperfecta type II and III. Amer J. Med. Genet. 50:190-194. Nakamura, M., Bringas, P. and Slavkin, H.C. (1991) Inner enamel epithelia synthesize and secrete enamel proteins during mouse molar occlusal "enamel-free area" development. J. Craniofac. Genet. Dev. Biol. 11:96-104. Slavkin, H.C. (1991) Molecular determinants during dental morphogenesis and cytodifferentiation: a review. J. Craniofac. Genetic & Develop. Biol. 11:338-349. Slavkin, H.C. (1991) Research creativity is in danger. The J. NIH Res. 30:36-39. Fincham, A.G., Hu, Y., Lau, E.C., Pavlova, Z., Slavkin, H.C. and Snead, M.L. (1990). Isolation and partial characterization of a human amelogenin from a single fetal dentition using HPLC techniques. Calcif Tissue Int. 47:105-111. Hata, R., Bessem, C., Bringas, Jr., P., Hsu, M-Y. and Slavkin, H.C. (1990). Epidermal growth factor regulates gene expression of both epithelial and mesenchymal cells in mouse molar tooth organs in culture. Cell Biol Int. Rep. 14(6):509-519. Sasano, Y., Kikunaga, S. and Slavkin, H.C. (1990) Development of embryonic mouse mandible in serumless, chemically-defined organ culture: morphogenesis and growth factors. Tissue Culture (Japanese) 16(11):424-429. Slavkin, H.C. (1990). Molecular determinants of tooth development: A review. Crit. Rev. Oral Biol. Med. (CRC Press) 1(1):1-16. Slavkin, H.C. (1990). Regulatory issues during early craniofacial development: A summary. Cleft Palate J. 27(2):121-130. Slavkin, H.C., Sasano, Y., Kikunaga, S., Bessem, C., Bringas, P., Jr., Mayo, M., Luo, W., Mak, G., Rall, L. and Snead, M.L. (1990). Cartilage, bone and tooth induction during early embryonic 44 Harold C. Slavkin mouse mandibular morphogenesis using serumless, chemically-defined medium. Connect. Tissue Res. 24:41-51. Fincham, A.G., Bessem, C., Bringas, P., Hu, Y., Snead, M.L. and Slavkin, H.C. (1989). Amelogenesis in vitro: a model for studies of epithelial postsecretory processing during tissue-specific extracellular matrix biomineralization. Differentiation, 41:62-71. Fincham, A.G., Hu, Y., Pavlova, Z., Slavkin, H.C. and Snead, M.L. (1989). Human Amelogenins: Sequences of "TRAP" Molecules. Calcif. Tissue Int. 45:243-250. Lau E.C., Mohandas T.K., Shapiro L.J., Slavkin H.C., Snead M.L. (1989) Human and mouse amelogenin gene loci are on the sex chromosomes. Genomics.4:162-168. Slavkin, H.C. (1989). The Changing Face of Dentistry: Craniofacial growth and development in the 1990's. Calif. Dent. Assoc. J. 17:10:26-37. Slavkin, H.C. (1989). Recombinant DNA Technology and Clinical Dentistry. Int. J. Prosthodont. 2:80-96. Slavkin, H.C. (1989). Splice of life: Towards understanding genetic determinants of oral diseases. Adv. Dent. Res. 3:1:42-57. Slavkin, H.C., Bessem, C., Fincham, A.G., Bringas, P., Santos, V., Snead, M.L. and Zeichner-David, M.(1989). Human and Mouse Cementum Proteins Immunologically Related to Enamel Proteins. Biochim. Biophys. Acta, 991:12-18. Slavkin, H.C., Bringas, P., Bessem, C., Santos, V., Nakamura, M., Hsu, M., Snead, M.L., Zeichner-David, M. and Fincham, A.G. (1989). Hertwig's Epithelial Root Sheath Differentiation and Initial Cementum and Bone Formation During Long-term Organ Culture of Mouse Mandibular First Molars Using Serumless, Chemically-Defined Medium. J. Periodont. Res. 23:28-40. Slavkin, H.C., Johnson, R., Oliver, P., Bringas, P., Jr., Don-Wheeler, G., Mayo, M. and Whitsett, J.A. (1989). Lamellar body formation precedes pulmonary surfactant apoprotein expression during embryonic mouse lung development in vivo and in vitro. Differentiation, 41:223-236. Slavkin, H.C., Bringas, P., Jr., Sasano, Y. and Mayo, M. (1989). Early embryonic mouse mandibular morphogenesis and cytodifferentiation in serumless, chemically-defined medium: A model for studies of autocrine and/or paracrine regulatory factors. J. Craniofac. Genet. Dev. Biol. 9:185-205. Snead, M.L., Luo, W., Oliver, P., Nakamura, M., Don-Wheeler, G., Bessem, C., Bell, G.I., Rall, L.B. and Slavkin, H.C. (1989). Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development. Dev. Biol. 134(2)420-429. 45 Harold C. Slavkin Evans, J., Bringas, P., Jr., Nakamura, M., Nakamura, E., Santos, V. and Slavkin, H.C. (1988). Metabolic expression of intrinsic developmental programs for dentine and enamel biomineralization in serumless, chemically-defined, organotypic culture. Calcif. Tissue. Int. 42:220-230. Jaskoll, Don-Wheeler, G., Johnson, R.C. and Slavkin, H.C. (1988). Embryonic mouse lung morphogenesis and type II cytodifferentiation in serumless, chemically-defined medium using prolonged in vitro cultures. Cell Differ. 24:105-118. Slavkin, H.C. (1988). Gene regulation in the development of oral tissues. 1987 Kreshover Lecture. J. Dent. Res. 67(9):1142-1149. Slavkin, H.C., Bessem, C., Bringas, P., Jr., Zeichner-David, M., Nanci, A. and Snead, M.L. (1988). Sequential expression and differential function of multiple enamel proteins during fetal, neonatal and early postnatal stages of mouse molar organogenesis. Differentiation, 37:26-39. Slavkin, H.C., MacDougall, M., Zeichner-David, M., Oliver, P., Nakamura, M. and Snead, M.L. (1988) Molecular determinants of cranial neural crest-derived odontogenic ectomesenchyme during dentinogenesis. Am. J. Med. Genet. 4:7-22. Slavkin, H.C. and Slavkin, L.E. (1988). Science curriculum and teaching for the 21st century. J. For The Education of the The Gifted, 2:35-61. Snead, M.L., Luo, W., Lau, E.C. and Slavkin, H.C. (1988). Spatial- and temporal-restricted pattern for amelogenin gene expression during mouse molar tooth organogenesis. Development, 104:77-85. Zeichner-David, M., Vides, J., MacDougall, M., Fincham, A., Snead, M.L., Bessem, C. and Slavkin, H.C. (1988). Biosynthesis and characterization of rabbit tooth enamel extracellular matrix proteins. Biochem. J. 251:631-641. Bringas, P., Jr., Nakamura, M., Nakamura, E., Evans, J. and Slavkin, H.C. (1987). Ultrastructural analysis of enamel formation during in vitro development using chemically-defined medium. Scanning Microsc. 1(3):1103-1108. Lau, E.C., Bessem, C.C., Slavkin, H.C., Zeichner-David, M. and Snead, M.L. (1987). Amelogenin antigenic domain defined by clonal epitope selection. Calcif. Tissue Int. 40:231-237. Nanci, A., Slavkin, H.C. and Smith, C.E. (1987). Application of high resolution immunocytochemistry to the study of the secretory, resorptive, and degradative functions of ameloblasts. Adv. Dent. Res. 1(2):148-161. 46 Harold C. Slavkin Nanci, A., Slavkin, H.C. and Smith, C.E. (1987). Immunocytochemical and radiographic evidence for secretion and intracellular degradation of enamel proteins by ameloblasts during the maturation stage of amelogenesis in rat incisors. Anat. Rec. 217:107-123. Samuel, N., Bessem, C., Bringas, P., Jr. and Slavkin, H.C. (1987). Immunochemical homology between elasmobranch scale and tooth extracellular matrix proteins in cephalosgyllium ventriosum. J. Craniofac. Genet. Develop. Biol. 7:371-386. Zeichner-David, M., MacDougall, M., Vides, J., Snead, M.L., Slavkin H.C., Turkell, S.B. and Pavlova, Z. (1987). Immunochemical and biochemical studies of human enamel proteins during neonatal development. J. Dent. Res. 66:50-56. Glazman, L., Bringas, P., Jr. and Slavkin, H.C. (1986). Comparison of trytophan-labeled constituents of developing rodent molar enamel matrix non-enamel occlusal cusp, Hertwig's epithelial root sheath, and presumptive root furcation regions: Light microscopic autoradiography. J. Craniofac. Genet. Dev. Biol. 6:171-188. Slavkin, H.C. (1986). Advances in therapeutics; Chemical agents for reduction of plaque. Emphasis Article J. Am. Dent. Assoc. 112:19-28. Davis, J.U., Bringas, P., Jr. and Slavkin, H.C. (1985). Quantitative localization of polystyrene microspheres following microinjection in the avian metencephalic neural crest pathway. J. Craniofac. Genet. Dev. Biol. 5:11-19. Jaskoll, T.F. and Slavkin, H.C. (1985). Ultrastructural and immunofluorescence studies of basal lamina alterations during mouse lung morphogenesis. Differentiation, 28:36-48. MacDougall, M., Zeichner-David, M. and Slavkin, H.C. (1985). Production and characterization of antibodies against murine dentine phosphoprotein. Biochem. J. 232:493-500. Nanci, A., Bendayan, M. and Slavkin, H.C. (1985). Enamel protein biosynthesis and secretion in mouse incisor secretory ameloblasts as revealed by high resolution immunocytochemistry. J. Histochem. Cytochem. 33:1153-1160. Slavkin, H.C. (1985). Developmental and immunogenetic features of biological aging. J. Am. Dent. Assoc. 109:451-454. Slavkin, H.C. (1985). Regional specification of cell specific gene expression during craniofacial development. J. Craniofac. Genet. Dev. Biol. Pruzansky Festschrift Edition (edited by M.M. Cohen and B.R. Rollnick), Supplement 1:57-66. 47 Harold C. Slavkin Snead, M.L., Lau, E.C., Zeichner-David, M., Fincham, A.G., Woo, S.L.C. and Slavkin, H.C. (1985). DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein. Biochem. Biophys. Res. Commun. 129:812-818. Ferguson, M.W.J., Honig, L.S. and Slavkin, H.C. (1984). Differentiation of cultural palatal shelves from alligator, chick and mouse embryos. Anat. Rec. 209(2):231-249. Honig, L.S., Smith, B.T., Slavkin, H.C. and Donahue, H.G. (1984). Influence of the major histocompatibility complex (H-2) on glucocorticoid-stimulated pulmonary surfactant synthesis in two congenic mouse strains. Proc. Soc. Exp. Biol. Med. 176:419-425. Jaskoll, T.F., Phelps, D., Taeusch, M.W., Smith, B.T. and Slavkin, H.C. (1984). Localization of pulmonary surfactant protein during mouse lung development. Dev. Biol. 106:256-261. Lehmann, R. and Slavkin, H.C. (1984). Identification of inner and outer cell proliferation centers during fetal tooth morphogenesis. J. Craniofac. Genet. Dev. Biol. 4:47-57. Ryan, U., Slavkin, H.C., Revel, J.-P., Massaro, D. and Gail, D. (1984). Conference report: Cell-to-cell interactions in the developing lung. Tissue Cell, 16:829-841. Slavkin, H.C. (1984). A prescription for the prevention of birth defects. USA Today 112(2466):87-89. Slavkin, H.C. (1984). Congenital craniofacial malformations: issues and perspectives. J. Prosthet. Dent. 51:109-118. Slavkin, H.C. (1984). Genetic engineering in dentistry: Current research at USC. CDA J. 12:146-150. Slavkin, H.C., Snead, M.L., Zeichner-David, M., Jaskoll, T.F. and Smith, B.T. (1984). Concepts of epithelial-mesenchymal interactions during development: Tooth and lung organogenesis. J. Cell Biochem. 26:117-125. Snead, M.L., Bringas, P., Jr., Bessem, C. and Slavkin, H.C. (1984). De novo gene expression detected by amelogenin gene transcript analysis. Dev. Biol. 104:255-258. Ferguson, M.W.J., Honig, L.S., Bringas, P., Jr. and Slavkin, H.C. (1983). Alligator mandibular development during long-term organ culture. In Vitro, 19:385-393. Greenberg, G., Bringas, P., Jr. and Slavkin, H.C. (1983). The epithelial genotype controls the pattern of ext enamel prism formation. Differentiation, 25:32-43. Nanci, A., Bringas, P., Jr., Samuel, N. and Slavkin, H.C. (1983). Selachian tooth development III. Ultrastructural features of secretory amelogenesis in Squalus acanthias. 48 Harold C. Slavkin J. Craniofac. Genet. Dev. Biol. 3:53-73. Riviere, G.G., Tarbox, G.S., Bringas, P., Jr. and Slavkin, H.C. (1983). Murine tooth germ transplantation after organ culture. J. Dent. Res. 62:980-984. Samuel, N., Bringas, P., Jr., Santos, V. and Slavkin, H.C. (1983). Selachian tooth development I. Histogenesis, morphogenesis and anatomical features in Squalus acanthias. J. Craniofac. Genet. Dev. Biol. 3:29-41. Slavkin, H.C. (1983). Craniofacial genetics and developmental biology: Implications for the future of academic dentistry. J. Dent. Educ. 47:231-238. Slavkin, H.C., Brownell, A.G., Bringas, P., Jr., MacDougall, M. and Bessem, C. (1983). Basal lamina persistence during epithelial-mesenchymal interactions in murine tooth development in vitro. J. Craniofac. Genet. Dev. Biol. 3:387-408. Slavkin, H.C., Samuel, N., Bringas, P., Jr., Nanci, A. and Santos, V. (1983). Selachian tooth development II. Immunolocalization of the amelogenin polypeptides in epithelium during secretory amelogenesis in Squala acanthias. J. Craniofac. Genet. Dev. Biol. 3:43-51. Slavkin, H.C., Graham, E., Zeichner-David, M. and Hildemann, W. (1983). Enamel-like antigens in hagfish: Possible evolutionary significance. Evolution, 37:404-412. Snead, M.L., Zeichner-David, M., Chandra, T., Robson, K.J.H., Woo, S.L.C. and Slavkin, H.C. (1983). Construction and identification of mouse amelogenin cDNA clones. Proc. Natl. Acad. Sci.U S A, 80:7254-7258. Tassin, M.T., Slavkin, H.C. and Weill, R. (1983). Criteria for distinction of different epithelial phenotypes covering murine palatal shelves at the stage of fusion. J. Craniofac. Genet. Dev. Biol. 3:91-115. Zeichner-David, M., MacDougall, M. and Slavkin, H.C. (1983). Enamelin gene expression during fetal and neonatal rabbit tooth organogenesis. Differentiation, 25:148-155. Zeichner-David, M., Slavkin, H.C., Lyaruu, D.M. and Termine, J.D. (1983). Biosynthesis and secretion of enamel proteins during hamster tooth development. Calcif. Tissue. Int. 35:366-371. Slavkin, H.C. (1982). Combinatorial process for extracellular matrix influences on gene expression: An hypothesis. J. Craniofac. Genet. Dev. Biol. 2:179-189. Slavkin, H.C. (1982). Higher education efforts to adjust and readjust (Commencement Address) Momentum 7(2):1-6. Slavkin, H.C. (1982). Prospects for dental research and development in the 1980's. 49 Harold C. Slavkin CDA J. 10:39-44. Slavkin, H.C., Bringas, P., Jr., Cummings, E. and Grodin, M.S. (1982). Initiation of quail and mouse mandibular chondrogenesis and osteogenesis in a serumless, chemically-defined medium. Calcif. Tissue. Int. 34:111-112. Slavkin, H.C. and Melnick, M. (1982). Maternal influences on congenital craniofacial malformations. Am. J. Orthod. 81(4):261-268. Slavkin, H.C., Zeichner-David, M., MacDougall, M., Bessem, C., Bringas, P., Jr., Honig, L.S., Lussky, J. and Vides, J. (1982). Enamel gene products during murine amelogenesis in vivo and in vitro. J. Dent. Res. 61:1467-1471. Slavkin, H.C., Zeichner-David, M., MacDougall, M., Bringas, P., Jr., Bessem, C. and Honig, L.S. (1982). Antibodies to murine amelogenins: Localization of enamel proteins during tooth organ development in vitro. Differentiation, 23:73-82. Brownell, A.G., Bessem, C.C. and Slavkin, H.C. (1981). Possible functions of mesenchyme cell-derived fibronectin during formation of basal lamina. Proc. Natl. Acad. Sci. U S A, 78(6):3711-3715. Cummings, E., Bringas, P. Jr., Grodin, M.S. and Slavkin, H.C. (1981). Epithelial-directed mesenchyme differentiation in vitro model of murine odontoblast differentiation mediated by quail epithelia. Differentiation, 20:1-9. Davies, A.M., Lumsden, A.G.S., Slavkin, H.C. and Burnstock, G. (1981). Influence of nerve growth factor on the embryonic mouse trigeminal ganglion in culture. Dev. Neurosci. 4:150-156. Jaskoll, T., Melnick, M., MacDougall, M., Brownell, A.G. and Slavkin, H.C. (1981). Spatio-temporal patterns of fibronectin distribution during embryonic development. II. Chick branchial arches. J. Craniofac. Genet. Dev. Biol. 1:203-212. Lumsden, A.G.S., Davies, A.M., Slavkin, H.C. and Burnstock, G. (1981). Neurite outgrowth from murine sensory ganglia cultured in a serumless medium. Dev. Neurosci. 4:176-180. Melnick, M., Jaskoll, T., Brownell, A.G., MacDougall, M., Bessem, C. and Slavkin, H.C. (1981). Spatiotemporal patterns of fibronectin distribution during embryonic development. I. Chick limbs. J. Embryol. Exp. Morph. 63:193-206. Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981). Corticosteriod-induced cleft lip in mice: A teratologic, topographic and histologic investigation. Am. J. Med. Genet. 10:333-350. Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981). Corticosteriod-induced cleft palate in mice and H-2 haplotype material and embryonic effects. Immunogenetics, 13:443-450. 50 Harold C. Slavkin Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981). The association of H-2 haplotype with implantation, survival, and growth of murine embryos. Immunogenetics, 14:303-308. Slavkin, H.C. (1981). The aging process and nutrition: Conception to senescence. Spec. Care Dentist, 1(1):31-36. Slavkin, H.C. (1980). Congenital craniofacial malformations: Of mice and men. Compend. Contin. Educ. Gen. Dent. 1(1):39-47. Slavkin, H.C. (1980). Human reproduction, congenital malformations and nutrition. In New Horizons in Nutrition for the Health Professions (edited by H.C. Slavkin), USC J. Contin. Dent. Educ. 1(2):12-37. Slavkin, H.C., Slavkin, M.D. and Bringas, P., Jr. (1980). Mineralization during long-term cultivation of chick embryos in vitro. Proc. Soc. Exp. Biol. Med. 163:249-257. Yamada, M., Bringas, P., Jr., Grodin, M., MacDougall, M., Cummings, E., Grimmett, J., Weliky, B. and Slavkin, H.C. (1980). Chemically-defined organ culture of embryonic mouse tooth organs: Morphogenesis, dentinogenesis and amelogenesis. J. Biol. Buccale. 8(2):127-139. Yamada, M., Bringas, P., Jr., Grodin, M., MacDougall, M. and Slavkin, H.C. (1980). Developmental comparisons of murine secretory amelogenesis in vivo, as xenografts on chick chorio-allantoic membrane, and in vitro. Calcif. Tissue Int. 31:161-171. Zeichner-David, M., Weliky, B.G. and Slavkin, H.C. (1980). Isolation and preliminary characterization of epithelial-specific messenger ribonucleic acids and their products during embryonic tooth development. Biochem. J. 185:489-496. Chrispens, J., Weliky, B., Bringas, P., Jr. and Slavkin, H.C. (1979). Proenamel enamel polypeptides: A concept. In Third International Symposium on Tooth Enamel (edited by J. Termine and M. Nylen), J. Dent. Res. 58(B):988-990. Hyatt-Fischer, H., Chrispens, J., O'Keefe, D. and Slavkin, H.C. (1979). An antisera for the fluorescent labeling of mouse amelogenesis. In: Third International Symposium on Tooth Enamel (edited by J. Termine and M. Nylen), J. Dent. Res. 58(B):1008-1009. Slavkin, H.C. (1979). Amelogenesis in vitro. Third International Symposium on Tooth Enamel (edited by J. Termine and M. Nylen), J. Dent. Res. 58(B):735-739. Slavkin, H.C. (1979). Congenital craniofacial malformations: Identifying individuals at risk. Ear Nose Throat J. 58(1):7-20. 51 Harold C. Slavkin Slavkin, H.C. (1979). Renaissance Relevance, utility and uselessness. J. Dent. Educ. 43(12):622-624. Slavkin, H.C. (1979). Report on the questionnaire survey. Third International Symposium on Tooth Enamel (edited by J. Termine and M. Nylen), J. Dent. Res. 58(B):1030. Slavkin, H.C. (1979). The nature and nurture of epithelial-mesenchymal interactions during tooth morphogenesis. J. Biol. Buccale. 6:189-203. Slavkin, H.C., Weliky, B., Stellar, W., Slavkin, M.D., Zeichner-Gancz, M., Bringas, P., Jr., Hyatt-Fischer, H., Shimizu, M. and Fukae, M. (1979). Ameloblast differentiation: Protein synthesis and secretion in fetal New Zealand white rabbit molar tooth organs and isolated epithelia in vitro. J. Biol. Buccale. 6:309-326. Bonner, J.J., Terasaki, P.I., Thompson, P., Holve, L.M., Wilson, L., Ebbin, A.J. and Slavkin, H.C. (1978). HLA phenotype frequencies in individuals with cleft lip and/or palate. Tissue Antigens, 12:228-232. Hata, R. and Slavkin, H.C. (1978). De novo induction of a gene product during heterologous epithelial-mesenchymal interactions in vitro. Proc. Natl. Acad. Sci. U S A, 75(6):2790-2794. Guenther, H.L., Croissant, R.D., Schonfeld, S.E. and Slavkin, H.C. (1977). Identification of four extracellular-matrix enamel proteins during embryonic-rabbit tooth-organ development. Biochem. J. 163:591-603. Lee-Own, V., Zeichner, M., Benveniste, K., Denny, P., Paglia, L. and Slavkin, H.C. (1977). Cell-free translation of messenger RNAs of embryonic tooth organs: Synthesis of the major extracellular matrix proteins. Biochem. Biophys. Res. Commun. 74(3):849-856. Schonfeld, S.E. and Slavkin, H.C. (1977). Demonstration of enamel matrix proteins on root-analogue surfaces of rabbit permanent incisor teeth. Calcif. Tissue Res. 24:223-229. Schonfeld, S.E., Trump, G.N. and Slavkin, H.C. (1977). Immunogenicity of two naturally occurring solid-phase enamel proteins. Proc Soc Exp Biol Med 155:111-114. Slavkin, H.C. (1977). New horizons in craniofacial anomalies research. N.Y. State J. Dent. 47(1):3-8. Sorgente, N., Brownell, A.G. and Slavkin, H.C. (1977). Basal lamina degradation: The identification of mammalian-like collagenase activity in mesenchymal-derived matrix vesicles. Biochem. Biophys. Res. Commun. 74(2):448-454. Lehmann, R. and Slavkin, H.C. (1976). Localization of 'transcriptively active' cells during odontogenesis using acridine orange ultrastructural cytochemistry. Devel. Biol. 49:438-456. 52 Harold C. Slavkin Slavkin, H.C. (1976). Towards a cellular and molecular understanding of periodontics: Cementogenesis revisited. J. Periodontol. 47(5):249-256. Slavkin, H.C. and Bringas, P., Jr. (1976). Epithelial-mesenchyme interactions during odontogenesis IV. Morphological evidence for direct heterotypic cell-cell contacts. Dev. Biol. 50:428-442. Slavkin, H.C., Croissant, R.D., Bringas, P., Jr., Matosian, P., Wilson, P., Mino, W. and Guenther, H. (1976). Matrix vesicle heterogeneity: Possible morphogenetic functions for matrix vesicles. Proceedings of the First International Conference on Matrix Vesicle Calcification, 35(2):127-134. Slavkin, H.C., Mino, W. and Bringas, P., Jr. (1976). The biosynthesis and secretion of precursor enamel protein by ameloblasts as visualized by autoradiography after tryptophan administration. Anat. Rec. 185(3):289-312. Bonner, J.J. and Slavkin, H.C. (1975). Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouse. Immunogenetics, 2:213-218. Slavkin, H.C. (1975). What is the role of the host in periodontal disease. Periodont. Abstr. 23(3):101-103. Trelstad, R.L., Slavkin, H.C. (1974). Collagen synthesis by the epithelial enamel organ of the embryonic rabbit tooth. Biochem. Biophys. Res. Commun. 59:443-449. Slavkin, H.C. (1974). Genetic alterations in craniofacial anomalies. J. Oral Surg. 32:333-342. Slavkin, H.C., Trump, G.N., Mansour, V., Matosian, P. and Mino, W.G. (1974). Localization of H-2 histocompatibility alloantigens on mouse embryonic tooth epithelial and mesenchymal cell surfaces. J. Cell Biol. 60:796-801. Slavkin, H.C. (1972). Preventative dentistry through nutritional awareness. Part I. San Fernando Valley Dental Soc. Bulletin, 6:10-11. Slavkin, H.C. (1972). Preventative dentistry through nutritional awareness. Part II. San Fernando Valley Dental Soc. Bulletin, 6:12-13. Slavkin, H.C. (1972). Preventative dentistry through nutritional awareness. Part III. San Fernando Valley Dental Soc. Bulletin, 6:10-11. Slavkin, H.C. (1972). Preventative dentistry through nutritional awareness. Part IV. San Fernando Valley Dental Soc. Bulletin, 6:14-15. 53 Harold C. Slavkin Slavkin, H.C. (1972). Preventative dentistry through nutritional awareness. Part V. San Fernando Valley Dental Soc. Bulletin, 6:8-9. Slavkin, H.C. (1972). Preventative dentistry through nutritional awareness. Part VI. San Fernando Valley Dental Soc. Bulletin, 6:16-17. Slavkin, H.C., Bringas, P., Jr., Croissant, R. and Bavetta, L.A. (1972). Epithelial-mesenchymal interactions during odontogenesis. II. Intercellular matrix vesicles. Mech. Ageing Dev. 1:139-161. Slavkin, H.C., Cameron, J.R., Bringas, P., Jr., LeBaron, R. and Bavetta, L.A. (1972). Dermal-epidermal interactions. Cultivation of embryonic rabbit gingiva and studies of heterotypic tissue recombinants on the chick chorio-allantoic membrane. Arch. Oral Biol. 17:585-590. Slavkin, H.C., Croissant, R. and Bringas, P., Jr. (1972). Epithelial-mesenchymal interactions during odontogenesis. III. A simple method for the isolation of matrix vesicles. J. Cell Biol. 53:841-849. Slavkin, H.C., Stahl, S.S., Yamada, L. and Levine, S. (1972). Speculations about gingival repair. J. Periodontol. 43:395-402. Slavkin, H.C. (1971). Tooth formation: A review. J. South Calif. State Dent. Assoc. 39:808-815. Slavkin, H.C. (1970). Epithelial-mesenchymal interactions related to periodontal disease. J. Periodontol. 41:373-381. Slavkin, H.C., Flores, P., Bringas, P., Jr., and Bavetta, L.A. (1970). Epithelial-mesenchymal interactions during odontogenesis. I. Isolation of several intercellular matrix low molecular weight methylated RNAs. Dev. Biol. 23(2):276-296. Slavkin, H.C., Bringas, P., Jr., and Bavetta, L.A. (1969). Ribonucleic acid within the extracellular matrix during embryonic tooth formation. J. Cell Physiol. 73:179-190. Slavkin, H.C., Bringas, P., Jr., Cameron, J.C., LeBaron, R. and Bavetta, L.A. (1969). Epithelial and mesenchymal cell interactions with extracellular matrix material in vitro. J. Embryol. Exp. Morph. 22:395-405. Slavkin, H.C., Bringas, P., Jr., Lebaron, R.D., Cameron, J.C. and Bavetta, L.A. (1969). The fine structure of the extracellular matrix during epithelio-mesenchymal interactions in the rabbit embryonic incisor. Anat. Rec. 165:237-255. 54 Harold C. Slavkin Slavkin, H.C. and Bavetta, L.A. (1968). Morphogenetic expressions during odontogenesis: A tool in developmental biology. Clin. Orthop. 59:97-109. Slavkin, H.C. and Bavetta, L.A. (1968). Odontogenesis in vivo and in xenografts on chick chorio-allantois. I. Collagen and hexosamine biosynthesis. Arch. Oral Biol. 13:145-154. Slavkin, H.C. and Bavetta, L.A. (1968). Organogenesis: Prolonged differentiation and growth of tooth primordia on the chick chorioallantoic membrane. Experientia, 24:192-194. Slavkin, H.C. and Bavetta, L.A. (1968). Odontogenetic epithelial-mesenchymal interactions in vitro. J. Dent. Res. 47:779-785. Slavkin, H.C. and Bavetta, L.A. (1968). Total protein, collagen, nucleic acids and calcium ions during rabbit odontogenesis. Arch. Oral Biol. 13:1465-1476. Slavkin, H.C., Beierle, J. and Bavetta, L.A. (1968). Odontogenesis: Cell-cell interactions in vitro. Nature, 217-269. Slavkin, H.C., Tetreault, C.E. Slavkin, H.C. and Bavetta, L.A. (1968). Carbon 14 tryptophan metabolism in developing rat molars. J. Dent. Res. 47:272-274. Slavkin, H.C., Tetreault, C., Nimni, M. and Bavetta, L.A. (1967). Autoradiographic and biochemical investigations of collagen biosynthesis and participation in the dentine extracellular organic matrix. Proc. Soc. Exp. Med. Biol. 126(2):439-442. Slavkin, H.C., Canter, M.R. and Canter, S.R. (1966). An anatomic study of the pterygomaxillary region in the craniums of infants and children. Oral Surg. Oral Med. Oral Pathol. 21(2):225-235. Slavkin, H.C. (1965). Anatomical investigation of the greater palatine foramen and canal. Alpha Omegan, 58:148-151. Slavkin, H.C. (1965). Dental amputation neuromas. JADA, 70:662-675. Canter, S.R., Slavkin, H.C. and Canter, M.R. (1964). Anatomical study of pterygopalatine fossa and canal: Considerations applicable to the anesthetization of the second division of the fifth cranial nerve. J. Oral Surg., Anesth. Hosp. Dent. Svc. 22:318-323. Monographs 55 Harold C. Slavkin Pruzansky, S. and Slavkin, H.C. (1982) An evaluation and assessment of the state of the science: Congenital and acquired craniofacial malformations. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health. Slavkin, H.C., Zeichner-David, M. and Siddiqui, M.A.Q. (1981) Molecular aspects of tooth morphogenesis and differentiation. Molecular Aspects of Medicine - Vol. 4(2):125-188. Slavkin, H.C. (1974) Tooth Formation: A Tool in Developmental Biology. Oral Sciences Reviews - Vol. 4:1-120. Chapters in Books Slavkin H.C. (in preparation) Personalized Oral Health Care and the Contemporary Health Care Environment (Chapter 1). In Personalized Oral Health Care: Concept Design to Clinical Practice (editor Peter Polverini). Slavkin H.C., Navazesh M, Patel P. (in press) Basic principles of human genomics: a primer for oral medicine. In Burket's Oral Medicine. 12th ed. (eds. Greenberg M, Glick M, Ship J) Hamilton, Ontario: BC Decker Inc. Slavkin H.C. (2011) Biotechnology in Dentistry: Advances in Genomics, Biomimetics and Tissue Engineering. In Dental Horizons: Essentials of Oral Health (edited by Rajiv Saini and Santosh Saini), Paras Medical Publisher, New Delhi, India, pp. 276-287. Chai Y, Lee M, Slavkin, HC, Warburton D (2011) Regulation of Embryogenesis. In: Fetal and Neonatal Physiology. Fourth Edition, Volume 1 (eds. R.A. Polin, W. W. Fox and S. H. Abman) Philadelphia, PA: Elsevier/WB Saunders Co., pp.49-58. Slavkin H.C., Navazesh M, Patel P. (2008) Basic principles of human genetics: a primer for oral medicine. In Burket's Oral Medicine. 11 ed. (eds. Greenberg M, Glick M, Ship J) Hamilton, Ontario: BC Decker Inc. pp 549-568. Slavkin H.C. (2007) Shaping the future. In Dental school leadership strategies : top deans on establishing a mission, recruiting quality faculty and students, and incorporating technology into education. Boston: Aspatore Books. Slavkin, H.C. (2004) Regulation of Embryogenesis. In: Fetal and Neonatal Physiology. Third Edition (eds. R. Polin, W. Fox and s. Abman) Philadelphia, PA: WB Saunders Co. Slavkin, H.C. (2002). Molecules and Faces: What is on the Horizon? In: Understanding Craniofacial Anomalies (eds. Mooney, M. and Siegel, M.). John Wiley and Sons, New York, pp.549-560 56 Harold C. Slavkin Chai Y, Slavkin HC (2002) Utilization of in vitro organ culture model to investigate the regularory mechanism of craniofacial development. In: “Experimental Oral Pathology” (Zhang, KH and Yu,XF, eds) PMPH Press, Beijing, China pp. 379-399. Slavkin, H.C. (2001). Basic Science Principles. In: Craniofacial Surgery-Science and Surgical Technique (eds. Lin, KY, Ogle, R.C. and Jane, J.A.). W.B. Saunders Co., Philadelphia, pp.ix-xi. Shum L, Takahashi K, Takahashi I, Nagata M, Tanaka O, Semba I, Tan DP, Nuckolls GH, and Slavkin, HC. (2000) Embryogenesis and the Classification of Craniofacial Dysmorphogenesis. In: Oral and Maxillofacial Surgery, Vol. 6. (eds. Baker, SB and Fonseca, RJ). W.B. Saunders Co., pp149-194 Slavkin, H.C. (1999) Dental and Craniofacial Science, and Education in 2020. Proceedings from the AADS 75th Anniversary Summit Conference. pp. 111-115 Slavkin, H.C. (1999). Oral health in the next century. In: Contact Point (ed. David Chambers). Univ of the Pacific School of Dentistry Millennium Issue. pp. 22-25 Slavkin H., Nuckolls G., Shum L. (1999) Craniofacial Development and Patterning. In: Methods in Molecular Biology, Vol, 136: Developmental Biology Protocols, Volume II. (eds. R.S. Tuan and C.W. Lo). Humana Press Inc., Totowa, NJ. pp. 45-54 Cohen W., Slavkin H.C. (1999) Periodontal Disease and Systemic Disease. In: Periodontal Medicine (eds. Genco R, Mealey B, Cohen W, Rose L). B.C. Decker, Inc. pp. 1-8 Nuckolls GH, Slavkin HC, Shum L. (1999) Bone Morphogenetic Protein Signaling in Limb and Craniofacial Development. In: Proceedings of the Biologicl Mechanisms of Tooth Eruption, Resorption and Replacement by Implants. (eds. Davidowitch, Z). Harvard Society for the Advancement of Orthodontics, EBSCO media, Birmingham, Alabama. pp 39-47. Slavkin H.C. (1999) Possibilities of Growth Modification: Nature Versus Nurture. In: McNamara JA Jr. (ed.), Growth Modification: what works, what doesn’t, and why. Craniofacial Growth Series, Volume 35. Ann Arbor: Center for Human Groth and Development, University of Michigan, pp. 1-15. Slavkin H.C., Shum L, Nuckolls G.H (1998) Ectodermal Dysplasia: A Synthesis Between Evolutionary, Development and Molecular Biology and Human Clinical Genetics. In: Molecular Basis of Epithelial Appendage Morphogenesis. (eds. Chuong C.M.). Landes Science Publishers. pp. 15-37 Slavkin, H.C. (1997) Regulation of Embryogenesis. In: Fetal and Neonatal Physiology. Second Edition (eds. R. Polin and W. Fox) Philadelphia, PA: WB Saunders Co. Pp. 37-47 57 Harold C. Slavkin Gorlin, R.J. and Slavkin, H.C. (1997). Embryology of the Face. In: Congenital Anomalies of the Ear, Nose, and Throat. (eds. T.L. Tewfik and V. DerKaloustian) New York: Oxford University Press. Pp. 287-296 Slavkin, H.C. (1997) Molecular Determinants of Anodontia. In: Studies in Stomatology & Craniofacial Biology (eds. M. Cohen, Jr., and B. Baum) Canada: IOS Press, pp. 397-405. Slavkin, H.C., Diekwisch, T. (1997) Molecular Strategies of Tooth Enamel Formation Are Highly Conserved During Vertebrate Evolution. In: CIBA Foundation (eds. D. Evered and S. Harnett) New York, NY: John Wiley & Sons, pp. 73-85 Slavkin, H. C. (1995) Recombinant DNA technology in the diagnosis and therapeutics of oral medicine. In: DNA, The Double Helix Forty Years: Perspective and Prospective, ed. D. Chambers, Ann. New York Acad. Sci., pp. 314-328. Slavkin, H.C. (1995) Antisense oligonucleotides: an experimental strategy to advance a causal analysis of development. In: Odontogenesis: Embryonic Dentition As A Tool For Developmental Biology, ed. J.V. Ruch, The International Journal of Developmental Biology, 39:123-126. Slavkin, H.C., Chai, Y., Hu, C.C., Millar-Groff, S. and Bringas, Jr., P. (1994). Intrinsic molecular determinants of tooth development from specification to root formation: A review. In: Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants. (ed. Z. Davidovitch) EBSCO Media, pp. 263-272. Chai, Y. and Slavkin, H.C. (1994). Biology of Bone Induction and its Clinical Applications. In: Oral and Maxillofacial Surgery Clinics of North America, (eds. W. Howard Davis and H. Sailer) Philadelphia: W.B. Saunders Company, 7(4)739-753. Slavkin, H.C. (1993). Enamel and dentine gene expression and caries resistance. In: Cariology for the Nineties (eds. Bowen, W.H. and Tabak, L.A.), pp. 145-154. Rochester, New York: University of Rochester Press. Slavkin, H.C., Hu, C.C., Sakakura, Y., Diekwisch, T., Chai, Y., Mayo, M., Bringas, Jr., P., Simmer, J., Mak, G., Sasano, Y. and Sasson, D. (1992) Gene expression, signal transduction and tissue-specific biomineralization during mammalian tooth development. In Critical Review in Eucaryotic Gene Expression (Eds. G.S. Stein, J.L. Stein and J.B. Lian) pp. 315-329. CRC Press, Inc. Slavkin, H.C., Hu, C.C., Sasano, Y., David, S., Bringas, P., Sakakura, Y., Santos, V. and Nakamura, M. (1992) Towards an understanding of tissue-specific biomineralization. In: Hard Tissue Mineralization and Demineralizations (eds. S. Suga and N. Watabe), pp. 1-15. Tokyo: Springer-Verlag. 58 Harold C. Slavkin Slavkin, H.C., Shum, L., Bringas, Jr., P., Sakakura, Y., Chai, Y., Mayo, M., Santos, V. and Werb, Z. (1992). EGF regulation of Meckel's cartilage morphogenesis during mandibular morphogenesis in serumless, chemically-defined medium in vitro. In: Chemistry and Biology of Mineralized Tissue (eds. H.C. Slavkin and P. Price), pp. 361-367. Amsterdam, Elsevier Scientific Publications. Slavkin, H.C., Shum, L., Bringas, P. and Werb, Z. (1992). Endogenous EGF regulated embryonic mouse mandibular morphogenesis in vitro using serumless, chemically-defined medium. In: The Biological Mechanisms of Tooth Eruption and Resorption(ed. Z. Davidovitch), pp. 37-46. Birmingham, AL: EBSCO Media. Slavkin, H.C. (1991). Future Prospects for Craniofacial Molecular Biology in the 1990s. In: Craniofacial Growth Series (from Symposium on Craniofacial Growth) (ed. D. Carlson and A. Ferrara), pp. 179-202. Ann Arbor: University of Michigan Press. Slavkin, H.C. (1991). Perspectives on morphogenesis. In: Fundamentals of Bone Growth: Methodology and Applications (eds. A.D. Dixon and B.G. Sarnat), pp. 23-34. Boca Raton, Florida: CRC Press. Slavkin, H.C., Kresja, R.J., Fincham, A.G., Bringas, P., Santos, V., Sasano, Y., Snead, M.L. and Zeichner-David, M. (1991). Evolution of enamel proteins: a paradigm for mechanisms of biomineralization. In: Mechanisms of Biomineralization (eds. S. Suga and H. Nakahara), pp. 383-389. Tokyo: Springer-Verlag. Slavkin, H.C. (1990). Cellular and molecular determinants during craniofacial development. In: Craniofacial Malformations: Embryology, Classification, Surgery (eds. M. Stricker, J. Van der Meulen, B. Raphael and R.F. Mazzola), pp. 1-20. London: Livingstone Publishers. Slavkin, H.C. (1990). The future of prevention for craniofacial defects. In: Risk Assessment in Dentistry. (ed. J.D. Bader), pp. 288-297. Chapel Hill: University of North Carolina Dental Ecology. Slavkin, H.C., Snead, M.L., Luo, W., Bringas, P., Kikunaga, S., Sasano, Y., Bessem, C., Mayo, M., MacDougall, M., Rall, L.B., Rappolee, D. and Werb, Z. (1990). Analysis of embryonic cartilage and bone induction in a defined culture system. In: Bone Regulatory Factors: Morphology, Biochemistry, Physiology and Pharmacology, Proceedings of NATO ASI, Erice, Italy, (eds. A. Pecile and B. deBernard), pp. 55-68. London: Plenum Publishing Company. Slavkin, H.C., Snead, M.L., Zeichner-David, M., Lau, E.C. and Fincham, A.G. (1990). Dental enamel biomineralization. A prospectus. MRS Proceedings (eds. P. Rieke, P. Calvert and M. Alper), pp. 3-8. MacDougall, M., Zeichner-David, M. and Slavkin, H.C. (1989). Characterization of extracellular and nascent dentin phosphoproteins. In: The Chemistry and Biology of 59 Harold C. Slavkin Mineralized Tissues, from the Proceedings of the Third International Conference on the Chemistry and Biology of Mineralized Tissue (Chatham), (eds. Glimcher and J.B. Lian), pp. 697-703. Gordon and Breach Science Publishers S.A. Slavkin, H.C. (1989). Positional signalling and patterning for amelogenesis in mouse molar tooth development. In: The Chemistry and Biology of Mineralized Tissues, from the Proceedings of the Third International Conference on the Chemistry and Biology of Mineralized Tissue (Chatham), (eds. Glimcher and J.B. Lian), pp. 91-100. Gordon and Breach Science Publishers S.A. Snead, M.L., Lau, E.C., Fincham, A.G., Zeichner-David, M., Davis, C. and Slavkin, H.C. (1989). Of mice and men: anatomy of the amelogenin gene. In: The Chemistry and Biology of Mineralized Tissues from the Proceedings of the Third International Conference on the Chemistry and Biology of Mineralized Tissue (Chatham), (eds. M.J. Glimcher and J.B. Lian), pp. 727-735. Gordon and Breach Science Publishers S.A. Zeichner-David, M., MacDougall, M., Davis, A., Vides, J., Snead, M.L. and Slavkin, H.C. (1989). Enamelins and amelogenins share the same aminoterminal sequence. In: The Chemistry and Biology of Mineralized Tissues, from the Proceedings of the Third International Conference on the Chemistry and Biology of Mineralized Tissue (Chatham), (eds. M.J. Glimcher and J.B. Lian), pp. 749-755. Gordon and Breach Science Publishers S.A. Slavkin, H.C. (1988). Molecular biology of dental development: a review. In: Biological Mechanisms of Tooth Eruption and Root Resorption (ed. Z. Davidovitch), pp. 107-116. Birmingham, Albama: Ebsco Media. Slavkin, H.C., Snead, M.L., Zeichner-David, M., MacDougall, M., Fincham, A., Lau, E.C., Luo, W., Nakamura, M., Oliver, P. and Evans, J. (1988). Factors influencing expression of dental ECM biomineralization. In: Cell and Molecular Biology of Hard Tissues, CIBA Foundation Symposium 135 (eds. G. Rodan and A. Caplan), pp. 22-41. Chichester, England: John Wiley and Sons. Snead, M.L., Lau, E.C., Zeichner-David, M., Nanci, A., Bendayan, M., Bringas, P., Jr., Bessem, C. and Slavkin, H.C. (1987). Relationship of the Ameloblast Biochemical Phenotype to Morpho-Cyto-Differentiation. In: Molecular Approaches to Developmental Biology (eds. R.A. Firtel and E.H. Davidson), pp. 641-652. New York: Alan R. Liss, Inc. Joskoll, T.F., Johnson, R., Don, G. and Slavkin, H.C. (1986). Embryonic mouse lung morphogenesis in serumless, chemically-defined medium in vitro. In: Progress in Developmental Biology, Part A (ed. H.C. Slavkin), pp. 381-384. New York: Alan R. Liss, Inc. Slavkin, H.C., Jaskoll, T.F., MacDougall, M. and Zeichner-David, M. (1986). Hormonal and non-hormonal features of selected epithelial-mesenchymal interactions during development. In: 60 Harold C. Slavkin Cellular Endocrinology Hormonal Control of Embryonic and Cellular Differentiation (eds. G. Serrero and J. Hayashi), pp. 93-102. New York: Alan R. Liss, Inc. Krejsa, R.J., Samuel, N., Bessem, C. and Slavkin (1985). Immunogenetic and phylogenetic comparisons between teleost scale and dental enameloid with mammalian enamel antigens. In: Tooth Morphogenesis and Differentiation (ed. by A.B. Belcourt and J.V. Ruch), pp. 369-376. Paris: INSERM. MacDougall, M., Zeichner-David, M., Bringas, P., Jr. and Slavkin, H.C. (1985). Dentine phosphoprotein expression during in vitro mouse tooth organ culture. In: The Second International Conference on the Chemistry and Biology of Mineralized Tissues (ed. W. Butler), pp. 177-181. New York: Elsevier/North Holland. Nanci, A., Bendayam, M., Bringas, P., Jr. and Slavkin, H.C. (1985). High resolution immunocytochemical localization of enamel proteins in mouse ameloblasts in situ and in culture. In: Tooth Morphogenesis and Differentiation (ed A.B. Belcourt and J.V. Ruch), pp. 333-340. Paris: INSERM. Slavkin, H.C. (1985). Current perspectives on enamel proteins. In: The Second International Conference on the Chemistry and Biology of Mineralized Tissues (ed. W. Butler), pp. 237-239. New York: Elsevier/North Holland. Slavkin, H.C., Snead, M.L., Zeichner-David, M., Jaskoll, T.F. and Smith, B.T. (1985). Concepts of epithelial-mesenchymal interactions during development: Tooth and lung organogenesis. In: Proceeding of the 1984 UCLA Symposia on Extracellular Matrix: Structure and Function (ed. A.H. Reddi), pp. 11-19. New York: Alan R. Liss. Slavkin, H.C., Zeichner-David, M., Snead, M.L., Samuel, N., Bessem, C. and Bringas, P., (1985). Genetic and phylogenetic aspects of enamel. In: Tooth Morphogenesis and Differentiation (eds. A.B. Belcourt and J.V. Ruch), pp. 341-354. Paris: INSERM. Snead, M.L., Lidsky, A.S., DiLella, A., Zeichner-David, M., Woo, S.L.C. and Slavkin, H.C. (1985). Of mice and men: The cloning of enamel gene sequences. In: Tooth Morphogenesis and Differentiation (eds. A.B. Belcourt and and J.V. Ruch), pp. 363-368. Paris: INSERM. Snead, M.L., Zeichner-David, M., Lau, E., DiLella, A., Woo, S.L.C. and Slavkin, H.C. (1985). Enamel gene expression in selected vertebrates using nucleic and hybridization probes. In: The Second International Conference on The Chemistry and Biology of Mineralized Tissues (ed. W. Butler), pp. 270-273. New York: Elsevier/North Holland. Zeichner-David, M., Snead, M. and Slavkin, H.C. (1985). Genetic differences in enamel gene products amongst mammalian species. In: Tooth Morphogenesis and Differentiation (eds. A.B. Belcourt and J.V. Ruch), pp. 355-362. Paris: INSERM. 61 Harold C. Slavkin Zeichner-David, M., Vides, J., Snead, M. and Slavkin, H.C. (1985). Enamel protein characterization by mRNA translation in a cell-free system. In: The Second International Conference on The Chemistry and Biology of Mineralized Tissues (ed. W. Butler), pp. 264-269. New York: Elsevier/North Holland Publishers. Nanci, A., Bendayan, M. and Slavkin, H.C. (1984). Distribution of enamel protein antigens during mouse incisor amelogenesis as revealed by high resolution immunocytochemistry. In: Tooth Enamel IV (eds. R.W. Fernhead and S. Suga), pp. 141-145. Amsterdam: Elsevier/North Holland Publishers. Slavkin, H.C. (1984). Morphogenesis of a complex organ: Vertebrate palate development. In: Current Topics in Developmental Biology, vol. 19 (ed. E.F. Zimmerman), pp. 1-16. New York: Academic Press. Slavkin, H.C., Snead, M.L., Zeichner-David, M., Bringas, P., Jr. and Greenberg, G.L. (1984). Amelogenin gene expression during epithelial-mesenchymal interactions. In: The Role of Extracellular Matrix in Development (ed. R.L. Trelstad), pp. 221-253. New York: Alan R. Liss, Inc. Slavkin, H.C., Zeichner-David, M., Snead, M.L., Bessem, C. and Santos, V. (1984). epithelial- mesenchymal interactions and enamel gene induction--phylogenetic implications. In: Tooth Enamel IV (eds. r.W. Fernhead and S. Suga), pp. 167-171. Amsterdam: Elsevier/North Holland Publishers. Slavkin, H.S., Zeichner-David, M., Snead, M.L., Graham, E.E., Samuel, N. and Ferguson, M.W.J. (1984). Amelogenesis in reptilia: Evolutionary aspects of enamel gene products. In: Structure, Function and Evolution of Reptiles (ed. M.W.J. Ferguson), pp. 275-303. London: Academic Press. Snead, M.L., Zeichner-David, M., Woo, S.L.C. and Slavkin, H.C. (1984). Construction and identification of moleculr clones to mouse enamel proteins: The anatomy and physiology of the enamel genes. In; Tooth Enamel IV (eds. R.W. Fearnhead and S. Suga), pp. 172-176. Amsterdam: Elsevier/North Holland Publishers. Zeichner-David, M., MacDougall, M., Vides, J., Snead, M. and Slavkin, H.C. (1984). Enamel gene expression in selected vertebrates. In: Tooth Enamel IV (eds. R.W. Fernhead and S. Suga), pp. 183-187. Amsterdam: Elsevier/North Holland Publishers. Slavkin, H.C. and Zeichne, M. (1983). Biosynthesis of enamel proteins. In: Handbook Series on Experimental Dentistry (ed. E.P. Lazzari), pp. 137-142. Boca Raton, Florida: CRC Press Inc. 62 Harold C. Slavkin Slavkin, H.C. and Zeichner-David, M. (1983). Regulatory processes during odontogenic epithelial-mesenchymal interactions. In: Control of Gene Expression in Early Development (ed. M.A.Q. Siddiqui), pp. 187-218. Boca Raton, Florida: CRC Press, Inc. Ferguson, M.W.J., Honig, L.S., Bringas, P., Jr. and Slavkin, H.C. (1982). In vivo and in vitro development of first branchial archderivatives in Alligator mississippiensis. In: Factors and Mechanisms Influencing Bone Growth (eds. A.D. Dixon and B.G. Sarnat), pp. 275-286. New York: Alan R. Liss, Inc. Slavkin, H.C. (1982). Structural and metabolic aspects of bone-forming systems. Summary. In: Current Advances in Skeletogenesis development, biomineralization, mediators and metabolic bone disease (eds. M. Silbermann and H.C. Slavkin), pp. 461-463. Amsterdam, The Netherlands: Excerpta Medica. Slavkin, H.C., Cummings, E., Bringas, P., Jr. and Honig, L.S. (1982). Eithelial-derived basal lamina regulation of mesenchymal cell differentiation. In: Embryonic Development: Part B: Cellular Aspects (eds. M.M. Burger and R. Weber), pp. 249-259. New York: Alan R. Liss, Inc. Slavkin, H.C., Honig, L. and Bringas, P., Jr. (1982). Experimental "dissection" of avian and murine tissue interactions using organ culture in a serumless medium free from exogenous (non- defined) factors. In: Factors and Mechanisms Influencing Bone Growth (eds. A. Dixon and B. Sarnat), pp. 217-228. New York: Alan R. Liss, Inc. Slavkin, H.C., Zeichner-David, M., Ferguson, M., Termine, J.D., Graham, E., MacDougall, M., Bringas, P., Jr., Bessem, C. and Grodin, M. (1982). Phylogenetic and immunogenetic aspects of enamel proteins. In: Oral Immunogenetics and Tissue Transplantation (eds. G.R. Riviere and W.H. Hildemann), pp. 241-251. New York: Elsevier/North Holland Publishers. Slavkin, H.C., Zeichner-David, M. and Siddiqui, M.A.Q. (1982). Enamel extracellular matrix: Differentiation specific gene products and the control of their synthesis and accumulation during development. In: Current Advances in Skeletogenesis developmen, biomineralization, mediators and metabolic bone disease (eds. M. Silbermann and H.C. Slavkin), pp. 24-33. Amsterdam, The Netherlands: Excerpta Medica. Slavkin, H.C. (1981). Biosynthesis of non-collagenous proteins. In: Chemisrtry and Biology of Mineralized Connective Tissues, (ed. A. Veis), pp. 409-415. New York: Elsevier/North Holland Publishers. Slavkin, H.C. (1981). Congenital craniofacial malformations: Perspectives in susceptibility. In: International Conference on Orthodontics (ed. H. Barrer), 289-296. Philadelphia: University of Pennsylvania Press. Slavkin, H.C., Bringas, P., Jr., Cummings, E. and Grodin, M.S. (1981). Murine mandibular chondrogenesis and osteogenesis in a serumless, chemically-defined medium. In: Chemistry 63 Harold C. Slavkin and Biology of Mineralized Connective Tissues (ed. A. Veis), pp. 445-448. New York: Elsevier/North Holland. Slavkin, H.C. and Zeichner-David, M. (1981). The possible mode of transmission for "inductive RNA" during epithelial-mesenchymal interactions. In: The Role of RNA in Reproduction and Development (eds. M.C. Niu and C. Hsiao-hui), pp. 686-713. Beijing: Science Press, New York: Van Nostran Reinhold Co. Brownell, A. and Slavkin, H.C. (1980). role of basal lamina in tissue interactions. In: Renal Physiology (eds. G.M. Berlyne and S. Thomas), pp. 193-204. S. Karger, Basel, Switzerland. Slavkin, H.C. (1980). Biologic regulatory mechanisms related to dentofacial deformities. In: Surgical Correction of Dentofacial Deformities (eds. W.H. Bell, W.R. Proffit and R.P. White, Jr.), pp. 1742-1786. Philadelphia: W.B. Saunders Co. Slavkin, H.C. (1980). Major histocompatibility complex (H-2)-linked genes affecting teratogen- induced congenital craniofacial malformations in mice. In: Etiology of Cleft Lip and Cleft Palate (eds. M. Melnick, D. Bixler and E.D. Shields), pp. 121-147. New York: Alan R. Liss, Inc. Slavkin, H.C. (1980). Vistas in congenital craniofacial malformations. In: Proceedings of the 8th National Conference on Speech Therapy (ed. J. Mitchell), pp. 5-20. England: University of Warick Press. Slavkin, H.C. and Melnick, M. (1980). Maternal factors, the major histocompatibility complex (H-2) and glucocorticosteriod-induced facial clefting in congenic murine strains. In: Current Research Trends in Prenatal Craniofacial Development (ed. R. Pratt), pp. 387-402. New York: Elsevier/North Holland Biomedical Press. Slavkin, H.C., Yamada, M., Bringas, Jr., P. and Grodin, M. (1980). Tooth epithelial differentiation in vitro and congenital craniofacial malformations. In: Birth Defects: Original Articles Series (eds. B.S. Danes, R. Cox and W.H.J. Douglas). New York: Alan R. Liss Inc. 16(2):211-230. Cohen, D.W., Listgarten, M., Tichman, N. and Slavkin, H.C. (1979). Pathogenesis of Periodontal Diseases. In: Current Advances in Oral Biology (eds. H.C. Slavkin and D.W. Cohen), pp. 1-65. Bristol, Pennsylvania: Distribution Systems, Inc. Slavkin, H.C. (1979). Craniofacial developmental biology. In: Current Advances in Oral Biology (eds. H.C. Slavkin and D.W. Cohen), pp. 1-65. Bristol, Pennsylvania: Distribution Systems, Inc. 64 Harold C. Slavkin Slavkin, H.C. (1979). Current concepts in human nutrition, human development and the prevention of disease. In: Current Advances in Oral Biology (eds. H.C. Slavkin and D.W. Cohen), pp. 1-71. Bristol, Pennsylvania: Distribution Systems, Inc. Slavkin, H.C. (1979). Epithelial-mesenchymal interactions and normal epithelial differentiation. In: Oral Premalignant Lesions - Epithelial Changes Prior to Malignancy (eds. I.C. MacKenzie and E. Dabelsteen), Iowa City: University of Iowa Press. Slavkin, H.C. (1979). Immunogenetics and congenital craniofacial malformations. In: Human Genetics in Dental Education (ed. H. Kopel), pp. 52-56. Los Angeles: University Press. Slavkin, H.C. (1979). Overview of research on craniofacial malformations: Gene regulation. In: Second International Conferences on the Diagnosis and Treatment of Craniofacial Anomalies (ed. J.M. Converse), pp. 68-81. St. Louis: The C.V. Mosby Company. Slavkin, H.C. (1979). Speculations regarding the influence of the major histocompatibility complex (H-2) upon congenital craniofacial malformations in inbred and congenic strains of mice. In: Craniofacial Dysmorphology: Understanding the Clinical Dilemma through Developmental Biology, Birth Defects: Original Article Series Vol. XV (ed. M. Melnick), pp. 43-54. New York: Alan R. Liss, Inc. Slavkin, H.C. (1978). Morphogenesis of the mandible. In: Symposium on Reconstruction of Jaw Deformity (ed. L.A. Whitaker), pp. 24-32. The C.V. St. Louis: Mosby Company. Slavkin, H.C., Croissant, R., Guenther, H.G. and Sorgente, N. (1978). The role of matrix vesicles in mineralization and calcification. In: Formation and Calcification of Hard Tissues (eds. R.V. Talmage and H. Ozawa), pp. 59-82. Tokyo: Shakai Hoken Publishing Company, Ltd. Slavkin, H.C., Trump, G., Schonfeld, S.E., Brownell, A.G., Sorgente, N. and Lee-Own, V. (1978). Epigenetic regulations of enamel protein synthesis during epithelial-mesenchymal interactions. In: Cell Interactions in Differentiation (eds. L. Saxen and L. Weiss), pp. 209-226. New York: Academic Press. Slavkin, H.C., Trump, G.N., Brownell, A.G. and Sorgente, N. (1977). Epithelial-mesenchymal interactions: mesenchymal specificity. In: Cell and Tissue Interactions (eds. J.W. Lash and M.M. burger), pp. 29-46. New York: Raven Press. Slavkin, H.C. and Bonner, J.J. (1976). Genetic control mechanisms during early oral facial development. In: Oral Facial Genetics (eds. R. Stewart and G. prescott), pp. 1-45. St. Louis: C.V. Mosby Company. Croissant, R.D., Guenther, H.L. and Slavkin, H.C. (1975). How are embryonic preameloblasts instructed by odontoblasts to synthesize enamel. In: Extracellular Matrix Influences on Gene Expression (eds. H.C. Slavkin and R.C. Greulich), pp. 515-521. New York: Academic Press. 65 Harold C. Slavkin Guenther, H.L., Croissant, R.D., Schonfeld, S.E. and Slavkin, H.C. (1975). Enamel proteins: Identification of epithelial specific differentiation products. In: Extracellular Matrix Influences on Gene Expression (eds. H.C. Slavkin and R.C. Greulich), pp. 387-397. New York: Academic Press. Slavkin, H.C. (1975). Current concepts in dermal-epidermal interactions. In: Peridontal Surgery--A current evaluation, American Lectures in Dentistry, (ed. S.S. Stahl), pp. 5-41. New York: Charles Thomas, Publishers. Slavkin, H.C. (1975). Current concepts in nutrition, molecular biology and the prevention of periodontal disease. In: Proceedings Workshop: Diet, Nutrition and Periodontal Disease, pp. 67-77. Philadelphia: J.B. Lippincott Company. Slavkin, H.C. (1975). The isolation and characterization of calcifying and non-calcifying matrix vesicles from dentine. In: International Colloquium on Physical Chemistry and Crystallography of Apatites of Biological Interest (ed. G. Montel), pp. 161-177. Paris: Centre National de la Recherche Scientifique. Slavkin, H.C., Croissant, R.D. and Guenther, H. (1975). The role of extracellular matrix macromolecules upon cell differentiation. In: Protides of the Biological Fluids Vol. XXII (ed. H. Peeters), pp. 23-32. Oxford: Pergamon Press. Slavkin, H.C., Crossant, R.D., Guenther, H., Matosian, P., Wilson, P. and Bringas, P., Jr. (1975). Epithelial-specific extracellular matrix influences on mesenchyme collagen biosynthesis in vitro. In: Extracellular Matrix Influences on Gene Expression (eds. H.C. Slavkin and R.C. Greulich), pp. 237-251. New York: Academic Press. Slavkin, H.C. (1974). Epithelial-mesenchymal induction. (Collection of five previously published papers). IN: Cellular Induction, Series on the Mechanism of Cell-Cell Interaction and Communication, (ed. R.T. Acton), 9-79, New York: MSS Information Corp. Slavkin, H.C. (1973). Message to specialize. In: The Laboratory of the Body, Washington, D.C.: American Dental Association. Slavkin, H.C. and Croissant, R. (1973). Intercellular communication during odontogenesis epithelial-mesenchymal interactions: Isolation of extracellular matrix vesicles containing RNA. In: The Role of RNA in Reproduction and Development (eds. M.C. Niu and S. Segal), pp. 247- 258, Amsterdam: North Holland Publishing Co. Slavkin, H.C. (1972). Intercellular communication during epidermal organ formation. In: Epidermal Wound Healing (eds. H.I. Maibach and D.T. Rovee), pp. 311-321. Chicago: Year Book Medical Publishers. 66 Harold C. Slavkin Slavkin, H.C. (1972). Intercellular communication during odontogenesis. In: Developmental Aspects of Oral Biology (eds. H.C. Slavkin and L.A. Bavetta), pp. 165-201. New York: Academic Press. Slavkin, H.C. (1972). The developmental aspects of extracellular matrices. In: The Comparative Molecular Biology of Extracellular Matrices (ed. H.C. Slavkin), pp. 1-75. New York: Academic Press. Stahl, S.S. and Slavkin, H.C. (1972). Development of gingival crevicular epithelium and periodontal disease. In: Developmental Aspects of Oral Biology (eds. H.C. Slavkin and L.A. Bavetta), pp. 325-350. New York: Academic Press. Slavkin, H.C. (1971). The dynamics of extracellular and cell surface protein interactions. In: Cellular and Molecular Renewal in the Mammalian Body, (eds. I.L. Cameron and J.D. Thrasher), pp. 221-275. New York: Academic Press. Slavkin, H.C. (1970). Cell aggregation: Molecular Specificity in outer cell surface materials. In: Phylogeny of Transplantation, Transplantation Proceedings (Supplement) (eds. W.H. Hildemann and E.L. Cooper), 11:199-201. Greulich, R.C. and Slavkin, H.C. (1965). Amino acid utilization in the synthesis of enamel and dentin matrices as visualized by autoradiography. In: The Use of Radioautography in Investigating Protein Synthesis (eds. C.P. Leblond and K.B. Warren), pp. 199-214. New York: Academic Press. Books Slavkin, HC (2012) The Birth of a Discipline: Craniofacial Biology. AEGIS Communications, Newtown, Pennsylvania. Slavkin, H.C. (2012) Atlanta (a novel). CreateSpace/Amazon.com. Slavkin, H.C. (1979) Developmental Craniofacial Biology, Philadelphia: Lea and Febiger. Books Edited Slavkin, H.C. and Price, P. (1992) Chemistry & Biology of Mineralized Tissues. Amsterdam: Elsevier Scientific Publishers. Slavkin, H.C. (1986). Progress in Developmental Biology. Part A and Part B Volumes. New York: Alan R. Liss, Inc.. 67 Harold C. Slavkin Engelman, D.M., Reiser, S.J., Slavkin, H.C. and Thomas, L. (1982-1985). The Human Body (a 26-volume series), Washington, D.C.: U.S. News Books. Silbermann, M. and H.C. Slavkin (1982). Current Advances in Skeletogenesis Development, Biomineralization, Mediators and Metabolic Bone Disease. The Netherlands: Excerpta Medica, Amsterdam. Slavkin, H.C. (1981). New Horizons in Nutrition for the Health Professions. Los Angeles: University of Southern California Press. Slavkin, H.C. and D.W. Cohen (1979). Current Advances in Oral Biology (a 12-volume series). Philadelphia: University of Pennsylvania Press. Slavkin, H.C. and R.C. Greulich (1975). Extracellular Matrix Influences on Gene Expression. New York: Academic Press. Slavkin, H.C. (1972). Comparative Molecular Biology of Extracellular Matrices. New York: Academic Press. Slavkin, H.C. and Lucien A. Bavetta (1972). Developmental Aspects of Oral Biology. New York: Academic Press. Editorials Slavkin, H.C., Bartold P.M. (2006) Challenges and Potential in Tissue Engineering. Periodontology 2000. 41:9-15. Slavkin, H.C. (2004) The Failure of Dentistry’s Social Contract with America and California’s Search for Legislative Solutions. “Guest Editorial” J. Dental Education. Slavkin, H.C. (1999) Preparing for Change in the 21st Century. “Guest Editorial” J. of Dental Hygiene. Slavkin, HC. (2000) Multidisciplinary Training Key to Future Biomedical Research. Interview with Dr. Harold Slavkin. American Association of Anatomists Newsletter. 9(1):8 Slavkin, H.C. (2000) Reflections on the Astonishing 20th Century. Alpha Omegan Journal (The Millennium Edition). 93:14-17. Slavkin, H.C. (1999) Biting Comments. Interview with Dr. Harold Slavkin. Secure Retirement. 8(2)44-48. 68 Harold C. Slavkin Slavkin, H.C. (1998) Spotlight on Excellence: Interview with Dr. Harold Slavkin. Periodontal Insights. p. 20 Slavkin, H.C. (1998) In the Spotlight: Harold C. Slavkin, D.D.S. J of Practical Hygiene. pp. 55- 56 Slavkin, H.C. (1997) Craniofacial-Oral-Dental Research in the 21st Century. “Guest Editorial” J. Dent. Res. 76(2)628-630 Slavkin, H.C. (1996) Synthesis at the Cutting Edge of Inquiry. “Guest Editorial” J. Public Health Dentistry. 56(4)169-170 Slavkin, H.C. (1989). Challenges and opportunities for the 21st century. "Guest Editorial," Forum (The Association of Canadian Faculties of Dentistry). Slavkin, H.C. (1988). "Genetic and epigenetic challenges in tooth development." J. Craniofac. Genet. Dev. Biol. 8(3):195-198. Slavkin, H.C. (1987). Does the broth become simpler? Serumless and chemically-defined medium for in vitro cell, tissue and organ cultures. J. Craniofac. Genet. Dev. Biol. 7:319-320. Slavkin, H.C. (1986). Vitamins acting as hormones during craniofacial morphogenesis? J. Craniofac. Genet. Dev. Biol. 6:95-97. Slavkin, H.C. (1985). Genes and morphogenesis--Challenges for developmental biology. J. Craniofac. Genet. Dev. Biol. 5(1):1-3. Slavkin, H.C. (1984). Craniofacial genetics and developmental biology: Research implications for the near future. J. Craniofac. Genet. Dev. Biol. 4:3-5. Slavkin, H.C. (1983). Epithelial-mesenchymal interactions during odontogenesis. J. Craniofac. Genet. Dev. Biol. 3(2):89-90. Slavkin, H.C. (1983). Malnutrition and congenital craniofacial malformations. J. Craniofac. Genet. Dev. Biol. 3(1):1-2. Slavkin, H.C. (1982). Extracellular matrix influences on gene expression. J. Craniofac. Genet. Dev. Biol. 2:97-98. Slavkin, H.C. (1982). High technology, biomedical ethics, and recombinant DNA impacts in the 1980s. J. Craniofac. Genet. Dev. Biol. 2:3-4. Slavkin, H.C. (1981). Craniofacial developmental biology upon the horizon. J. Craniofac. Genet. Dev. Biol. 1:337-340. 69 Harold C. Slavkin Films and Videos Slavkin, H.C. (2000) The Mouth: The Window to Good Health, 4 minutes, 30 seconds. Produced by Videodiscovery, Inc., Seattle, WA. Slavkin, H.C. (1998) OpenWide: Celebrating 50 Years at the NIDCR, 3 minutes, 46 seconds. Produced by Mona Kanin for the NIDR. Slavkin, H.C. (1997) NIDR at Fifty: Shaping the Future, 10 minutes, 35 seconds. Produced by Mona Kanin for the NIDR. Slavkin, H.C. (1985) A Lifetime of Change, Public Broadcasting Company (PBS), 28 minutes, (Executive Producer and Writer). Slavkin, H.C. (1984) Genetic Engineering, Why in the World? Public Broadcasting Company (PBS), 30 minutes. Slavkin, H.C. Development and Differentiation, McGraw-Hill Films, 16 mm. Color and Sound, 22 minutes), (Consultant). Slavkin, H.C. and Coe, G. (1972) Intercellular Communication, Department of Cinema, University of Southern California, 16 mm. Color and sound, 10 minutes. LECTURES BY INVITATION (Selected Presentations: 2000 - Present) Keynote Address: “Genomics enters Oral Health Care” Institute of Oral Health Care Palm Springs, California October 23-25th 2014 Keynote Address: “The Future of Craniofacial Biology” US/Japanese Biomedical Collaborations NIDCR/NIH, Bethesda, Maryland September 3rd 2014 Keynote Address: “Oral Health Integration into Primary Health Care” Annual Conference of Health Insurers Sponsored by Renaissance Health Service Corporation Bar Harbour Inn, Michigan 70 Harold C. Slavkin August 2nd, 2014 Commencement Speech: “Advocacy for Comprehensive Health Care for All American” A.T. Stills School of Dentistry Mesa, Arizona June 6th 2014 Lecture – “Genomics and Clinical Dentistry” CE Course, Ostrow School of Dentistry Saturday April 26th 2014 Lecture – Scientific Research and Inter-Professional Education Transformation of Dental Education Chicago, Illinois September 2013 Lecture – “Reflections on the Birth of a Discipline: Craniofacial Biology” Gordon Research Conference Craniofacial Morphogenesis & Tissue Engineering Ventura, California March 22nd 2012 Lecture – “Impact of science on dental education” 75th Anniversary of the Journal of Dental Education (JDE) Annual ADEA Meetings Orlando, Florida March 19th 2012 Lecture – “From Gene to Community” Michigan Macomb County Dental Society Royal Park Hotel, Rochester, Michigan November 4th 2011 Lecture – “IOM Oral Health Initiative Reports” Deans Institute The Breakers, Palm Beach, Florida August 5th 2011 Commencement Speech – “Our enlightened self-interest” Graduation School of Dentistry, UCSF June, 2011 Lecture(s) – “Brave New World” and “Human Genetics #101” 71 Harold C. Slavkin Delta Dental of Idaho, Boise, Idaho April, 2009 Lecture – “Dental Technology Education for the 21st Century” 4th International Congress of Dental Technology, Osaka, Japan November 22, 2008 Lecture -"The Next Frontier: Nanobiotechnology in Clinical Dentistry" USC 7th International Endodontic Symposium, Los Angeles, CA November 14, 2008 Lecture – “A National Dental Perspective” American Public Health Association's Annual Meeting and Exposition, San Diego, CA October 27, 2008 Keynote Address – “Future of Oral Health Research” University of Michigan Clinical Research Symposium, Ann Arbor, MI September 12, 2008 Lecture – “Nanobiotechnology Meets Clinical Dentistry in the 21st Century” Pacific Coast Society for Prosthodontics, Kona, HI June 19, 2008 Lecture – “Dental Education in the 21st Century” 8th International Symposium and 40th Anniversary of Yonsei University College of Dentistry, Seoul, Korea May 23, 2008 Lecture - "Maps, Codes, and Meaning: Tissue Engineering in Clinical Dentistry" Star of the North Dental Meeting, Saint Paul, MN April 12, 2008 Lecture - "Biomemetic Tissue Engineering and Generation: Nanotechnology Meets Clinical Dentistry in the 21st Century” and “From George Washington's Dentures to Tooth Regeneration" 72 Harold C. Slavkin Hinman Meeting, Atlanta, GA March 14, 2008 Lecture - “What the future holds for Ectodermal Dysplasias” International Conference on Ectodermal Dysplasia Classification, Charleston, SC March 12, 2008 Keynote Address –“Beyond Access to Care ~ The Role of Family and Community in Children’s Oral Health” Children's Oral Health Summit, San Luis Obispo, CA February 22, 2008 Keynote Address - “Emerging Opportunities for Dental Research and Education” University of Michigan Annual Research Day, Ann Arbor, MI February 12, 2008 Lecture - "Dental Education in the 21st Century: The USC Model Revisited" Presentation at Glendale Academy of Dentists, Glendale, CA January 3, 2008 Lecture -"The Changing Opportunities for Dental Education" 55th Annual JADR Meeting, Japan November 17, 2007 Lecture - "Common Pediatric Dental Emergencies and Their Management" American Academy of Pediatrics May 28, 2007 Lecture - "Applying Dental Varnish in the General Pediatrician's Office and How to Get Paid for it" American Academy of Pediatrics May 27, 2007 Lecture -"Stem Cells in Dentistry" Virtual Seminar, National Association of Dental Plans May 24, 2007 73 Harold C. Slavkin Closing Presentation at the Oral Health in LA Forum April 19, 2007 Keynote Address - "Emerging Opportunities for Dental Research and Education" University of Tennessee Health Science Center College of Dentistry Research Day February 20, 2007 Keynote Address -"Emerging Opportunities for Dental Research and Education" University of Illinois at Chicago College of Dentistry Research Day February 7, 2007 Lecture - "Trends in Oral Health Care" USC Marshall School of Business February 3, 2007 Presentation at the Western Pedodontic and Odontic Society Meeting Mammoth, CA January 20, 2007 Lecture- “The Role of Community if Children’s Oral Health” Community Clinic Association of Los Angeles County 6th Annual Health Care Symposium Innovations and Challenges in Caring for the Underserved Burbank, CA November 30, 2006 Keynote Address- “Children’s Oral Health” 5th Annual Community Forum on the Conditions of Children in Orange County, California State University, Fullerton, CA November 11, 2006 Keynote Address- “Emerging Opportunities for Dental Education” Showa University 30th Anniversary, Japan November 4, 2006 74 Harold C. Slavkin Lecture- “Emerging Opportunities of Dental Research and Education in the 21st Century” Kanagawa Dental College, Lecture for scientists and clinicians Japan November 2, 2006 Lecture- “The Changing Opportunities for Dental Education” Tsurumi University School of Dentistry Japan October 30, 2006 Lecture- “Future Opportunities of Dentistry” Kyushu University School of Dentistry, Lecture for Dental Faculty Japan October 25, 2006 Lecture- “Dentistry 101: The Dental Exam” American Academy of Pediatrics 23rd Annual Current Advances in Pediatrics Irvine, CA October 20, 2006 Lecture- “Maps, Codes and Meaning: Tissue engineering in clinical dentistry” American Dental Association 147th Annual Session Las Vegas, NV October 16, 2006 & October 18, 2006 Lecture- “Human Genome Project” AHIP Dental Relations Committee Meeting Presentation Washington, DC October 13, 2006 Lecture- “Future Opportunities of Clinical Dentistry” De La Salle Binational Symposium Leon, Guanajuato, Mexico September 29, 2006 Lecture- “The Mouth: A Mirror to Wellness” National Museum of Dentistry’s 10th year Anniversary Gala 75 Harold C. Slavkin Baltimore, MD June 23, 2006 Lecture- "The Life of a Child: The Role of Family and Community in Children’s Oral Health" USC/CHOC Pediatric Dental Residency Program Event Garden Grove, CA May 10, 2006 Keynote Address-“Maps, Codes, and Meaning: Tissue Engineering in Clinical Dentistry” 31st Annual USC Periodontal & Implant Symposium Los Angeles, CA January 27, 2006 Lecture-"Dentistry based on Gene Therapy" UNAM Program Mexico City, Mexico January 20, 2006 Lecture- "Impact of Social, Biotechnological, and Educational changes on the future of Dentistry” UNAM Program Mexico City, Mexico January 19, 2006 Lecture- “Tissue Engineering in the New Century” Pacific Coast Society for Prosthodontics Marina del Rey, California June 25th, 2005 Keynote Address- “Genetics 102” National Oral Health Conference Pittsburgh, Pennsylvania May 5th 2005 Lecture-“Enter the Genetics of Complex Human Diseases” International Association of Dental Research (IADR); Baltimore, Maryland March 15th 2005 Lecture- "The Future of Oral Health"; UC San Diego Free Dental Clinic Project San Diego, CA 76 Harold C. Slavkin December 2, 2004 Lecture- "Genomic and Proteomic Influence on Therapeutic Future" Universidad Naciaonal Autonoma de Mexico (UNAM) Mexico City, Mexico November 18, 2004 Lecture- "Genetic Future Dentistry" USC-AAOM Symposium Los Angeles, California November 6-9, 2004 Keynote Address- "Scientific and Professional Success" Hinman Student Research Symposium Memphis, Tennessee October 29, 2004 Lecture- "The Next Frontier" AAOMS Meeting San Francisco, California September 30, 2004 Lecture- "Emerging Opportunities in Oral Health" NADP 16th Annual Conference St. Petersburg, Florida September 23, 2004 Lecture- "Update on Oral Health Issues Facing Dentistry Today" CDA Scientific Sessions San Francisco, California September 9, 2004 Lecture- "Leadership in Research: Organizing Genius" UOP National Leadership Symposium San Francisco, California August 27, 2004 Lecture- "Deans Approach to Faculty Recruitment and Funding" 91st Annual NDA Convention- Minority Facutly & Administrator's Forum Los Angeles, California 77 Harold C. Slavkin July 30, 2004 Lecture- "Innovations in Learning: Critical Thinking and Problem Based Learning" AGD Annual Meeting Anaheim, California July 8, 2004 Lecture- "Enhancing the Vitality of the National Institutes of Health: Organizational Change to Meet New Challenges: A Summary" NCI Tobacco Control Investigators San Diego, California June 2, 2004 Keynote- "Emerging Opportunities for Oral Health" American Association of Dental Consultants Fort Meyers, Florida May 6, 2004 Lecture- "Genomics: Implications for Oral Health and Disease" National Oral Health Conference Los Angles, California May 3-4, 2004 Lecture- "The Future of Pediatric Dentistyr in California" California Society of Pediatric Dentistry La Jolla, California April 2, 2004 Keynote- "The Social Contract Between Society and the Oral Health Profession" SCLARC, Oral Health Conference Los Angeles, California March 27, 2004 Lecture- “Genomes, Transcriptomes, Proteomes and OralCancer" The San Deigo American Cancer Society's Head and Neck Committee La Jolla, California February 27, 2004 78 Harold C. Slavkin Lecture- "The Next Frontier: Oral Health in the Next 21st Century" NYU College of Dentistry New York, NY February 19, 2004 Lecture- "Oral Health Opportunities for the 21st Cetury" San Gabriel Valley Dental Society Alhambra, CA February 17, 2004 Lecture- "The Social Contract Between Dentistry and Society" American College / New England Boston, MA January 31, 2004 Lecture- "Expanding Opportunities for the Oral Health Professions" Yankee Dental Congress Boston, MA January 31, 2004 Lecture- "The Human Genome and Dentistry" Yankee Dental Congress Boston, MA January 30, 2004 Lecture- "The Human Genome Impacts on Clinical Dentistry" Seattle Study Club Laguna Niguel, CA January 28, 2004 Lecture- Grand Rounds, "Pediatric Providers:Enhancing the Link Between Oral Health and Overall Health" Children’s Hospital of San Diego San Diego, California March 14, 2003 Lecture- "Tissue Engineering-Modifying the Healing Response" Academy of Osseointegration Boston, Massachusetts 79 Harold C. Slavkin February 27, 2003 Lecture- "Genetics and the Genome Project: Relevance to the Practicing Orthodontist" 30th Annual Moyers Symposium University of Michigan February 22, 2003 Lecture- "Biological Solutions to Biological Problems: The Post Genomic Era" Southern California Academy of Oral Pathology Los Angeles, California January 15, 2003 Testimony- "Health Risks for Pregnant Women, Children, Diabetics from Mercury in Amalgam" Dental Board of California November 7, 2002 Keynote- “Improving Dental Health for All California Children” California Children’s Dental Disease Prevention Program Conference Sacramento, California October 2, 2002 Lecture- “New Research in Dentistry: Implications for Clinical Practice” Pinnacle Group, Dentsply International Reno, Nevada September 20, 2002 Lecture- “Biotechnology Meets Clinical Dentistry in the 21st Century” Ohio Dental Association Columbus, Ohio September 12, 2002 Lecture- “The Future of Clinical Dentistry” Washington State Dental Association Seattle, Washington July 26, 2002 Lecture- “Grand Rounds” 80 Harold C. Slavkin Children’s Hospital Los Angeles Los Angeles, California July 12, 2002 Lecture- “Beyond Genomics: the Nexus Between Biotechnology, Tissue Engineering & Pediatric Clinical Dentistry in a New Century” Japanese Society of Pediatric Dentistry Makuhari-Messe, Japan June 6, 2002 Lecture- “Beyond Genomics” Graduate School , Tokyo Dental College Tokyo, Japan June 4, 2002 Lecture- “What Plans Need to Know about New Professionals” California Association of Dental Plans Indian Wells, California May 9, 2002 Lecture- “The Human Genome, Oral Infection, Systemic Disease & Clinical Dentistry in the 21st Century” Kern County Dental Society Bakersfield, California March 22, 2002 Keynote Academy of Laser Dentistry La Jolla, California March 14, 2002 Lecture- “Predoctoral Education in Pediatric Dentistry: A Key to Access” ADEA Annual Conference San Diego, California March 4, 2002 Lecture- “Biotechnology in Dentistry” Dentigenix Seattle Washington March 1, 2002 81 Harold C. Slavkin Lecture- “A Changing Landscape for Oral Health Professionals” The 27th Annual Review of Dentistry Maui, Hawaii August 8-18, 2001 Keynote- The National Foundation for Ectodermal Dysphasia: Twentieth Anniversary St. Louis, Missouri July 19, 2001 Keynote- “Pulp Biology Workshop” Dentin/ Pulp Complex 2001 Chiba City, Japan July 1, 2001 Lecture- “Future Technology” IADR, GC International Symposium Chiba City, Japan June 30, 2001 Lecture- “New Frontiers: Genomics and Biomimetics” Kanagawa University Kanagawa, Japan June 26, 2001 Keynote- “Advances in Craniofacial Mollecular Biology” Kyoto University Kyoto, Japan June 25, 2001 Keynote- “Future of Clinical Dentistry” Delta Dental Pebble Beach, CA June 15, 2001 Lecture- “Oral Health Disparities” Irvine Children & Families Commission, Beckman Center University of California at Irvine Irvine, CA June 6, 2001 Lecture- “The Biotechnology Century: Back to the basics and Beyond Y2K” 82 Harold C. Slavkin The New Odontic Seminar Los Angeles, CA June 1, 2001 Keynote- “The Human Genome and Oral Systemic Diseases” Distinguished Professor Symposium University of Washington Seattle, WA May 24, 2001 Lecture- “The Human Genome and Oral Systemic Diseases” John Sullivan Memorial Lecture University of Tennessee Knoxville, Tennesee April 27, 2001 Keynote- “The Future of Dentistry” College of Dentistry Anaheim, CA April 20, 2001 Lecture- “The Human Genome and the Future of Oral Health” Delta Dental Plan of Massachusetts Boston, Massachusetts October 24, 2000 Lecture - “Prospects for Dental Science, Education and Practice” 22nd Asia Pacific Dental Congress Tokyo, Japan May 28, 2000 Commencement - University of Detroit Mercy School of Dentistry Detroit, Michigan May 20, 2000 John Valentine Mershon Memorial Lecture, AAO Annual Lecture “ The Language and Meaning of DNA, Craniofacial Growth and Development” Chicago, IL April 29, 2000 83 Harold C. Slavkin Keynote – “Future Trends in Dentistry: Paradigm for the New Millennium” International Dental Exhibition and Meeting (IDEM 2000) Singapore April 14, 2000 Presentation - 1st Smile Train Cleft Lip and Palate Symposium (Presentation presented via video tape) Beijing, China March 2-4, 2000 Lecture “Biomimetics in the 21st Century” Memorial Sloan-Kettering Cancer Center Surgery Grand Rounds New York, NY February 28, 2000 Lecture “Human Faces, DNA Chips and the Human Genome” American Association for the Advancement of Science Annual Meeting Washington, DC February 18, 2000 PREVIOUS EMPLOYMENT 1995-2000 Director National Institute of Craniofacial Dental Research National Institutes of Health Bethesda, Maryland 1989-1995 Director Center for Craniofacial Molecular Biology School of Dentistry University of Southern California Los Angeles, California 1969-1989 Director and Principal Investigator School of Dentistry University of Southern California Los Angeles, California 1965-1972 Private Practice (General Dentistry), Part-Time, Westwood Village, Los Angeles 1962-1966 Research Technical Assistant 84 Harold C. Slavkin Department of Anatomy School of Dentistry and Medicine University of California, Los Angeles (Professor Richard C. Greulich 1955-1958 Technician, U.S. Army Dental Corps (Enlisted Soldier), Walter Reed Medical Center and Armed Forces Institute of Pathology 85 TAB 24 Armed Forces Radiobiology Research Institute Report Uniformed Services University of the Health Sciences Board of Regents Board Brief Submitted by: Col L. Andrew Huff, USAF, MC, SFS Date: 5 Sep 2014 Title & Department: Director, AFRRI Phone 301-295-1210 Purpose: Information X Action Subject: Director’s Report for AFRRI Institute of Medicine Report: “Research on Health Effects of Low-Level Ionizing Radiation Exposure: Opportunities for the Armed Forces Radiobiology Research Institute” released on 11 June 2014 Our request of the study (2012): 1. Identify current research directions in low-dose ionizing radiation. 2. Assess how AFRRI programs are advancing research along these directions. 3. Identify opportunities for AFRRI to advance understanding of low-dose radiation and military operations. 4. Assess the demand for radiobiology researchers and examine workforce projections. Results were: a. No shortage of radiobiology researchers currently. b. Supply will not meet demand in the coming years. Other findings and our responses (where appropriate) 1. AFRRI is a unique national asset: programs, outreach, research, guidance, infrastructure 2. Port response materials, forms and tools to tablets and smart phones o We delivered these requests to the USUHS VP for Information and Education. 3. Coordinate within the Services to standardize military radiological response teams; ensure teams are properly equipped, and 4. Integrate/coordinate DoD purchases, commissioning, acquisition, testing, maintenance and use of radioactivity detection instruments o We are initiating contact with Major General West, Joint Staff Surgeon, and her staff to determine a way ahead with these two recommendations. 5. Psychological effects: source of information, training and research (collaborate with USUHS) o We passed this information to the USUHS Center for the Study of Traumatic Stress. 6. Bolster Radiation Biology department; accelerate training and recruitment o We stand ready to advance this recommendation when a validated DoD requirement is identified and funded. 7. Epidemiologic and risk assessment studies using molecular and cellular indicators of low-level radiation effects and 8. Pursue low-level exposure research and collaboration; add this knowledge to training materials October 2014 o AFRRI’s Director, Deputy Director and Scientific Advisor along with the USUHS VP for Research met with Dr. David Smith, DASD(HA) for Force Health Protection and Readiness in August. The consensus was that while low-level ionizing radiation research would be important to DoD, the larger issues to address were: . a plan to get AFRRI drug candidates/therapeutics into advanced development . overall program management and advocacy for radiobiology research within DoD 9. Make AFRRI facilities “more open to use by outside investigators interested in conducting research consistent with its mission.” o This will require improved staffing before addressing other factors. 10. Scientific Director (vs Scientific Advisor) and “chain of command” o We are re-evaluating our organizational chart to empower the Scientific Advisor. 11. External program evaluation o We are working with the USUHS Office of General Counsel to select scientists who could review AFRRI’s research portfolio. o After establishing the scientists to conduct the external review, we will seek funding. o Ideally, the agency providing overall program management would also periodically review AFRRI’s research program (possibly the US Army Medical Research and Materiel Command). Facility modernization/renovation (major): 1. Completed since May 2014 a. Eleven laboratories b. Freezer room c. Reactor area intercoms upgrade d. VSD drain replacement (2nd & 3rd floors) 2. Nearing completion in FY14 a. Improved shielding for calibration lab (Cesium-137 source) b. Physical security upgrades (software, cameras, badge readers, fiber optic backbone, exterior lighting) c. BSL-3 lab ventilation upgrade 3. Ongoing projects for FY14 a. Repair damaged roof for large bore CT room b. Reactor prep room renovation c. Upgrade to digital HVAC controls d. Expand veterinary support space e. Electrical upgrade throughout the facility Veterinary sciences: 1. Staffing a. Husbandry manager needed; current manager out for past year (leave without pay) b. Veterinary technicians – continuity for training and experience: i. Civilians: tied to protocols ii. Military: frequent changes and moves iii. Growth in large animal studies (NHP and minipig) iv. GLP protocols v. After hours monitoring of animals October 2014 vi. Solution: centralized VSD staff 2. Capacity limitations for NHPs and minipigs a. Memorandum of Agreement with NIH: primate procurement and housing 3. Aging facility: phased restoration and modernization with dedicated funds Military Medical Operations: 1. Medical Effects of Ionizing Radiation – FY14 a. 29 courses with about 1200 students b. CME: 22.5 hours c. Cost: about $100 per student; or $4 per CME hour d. “Just in time training” – after simulated detonation disaster 2. Medical Radiobiology Advisory Teams – Two teams expandable to four. List of exercises: a. Department of Energy nuclear weapon accident, April 2014. Advisory only b. Joint Special Ops Command source recovery mission, Ft. Bragg, May 2014 c. ATROPIAN PHOENIX, June 2014, Aberdeen Edgewood. Nuclear reprocessing plant d. Ft. Belvoir Community Hospital mass casualty exercise, July 2014 e. VIBRANT RESPONSE, July/Aug 2014, Camp Atterbury, IN. Improvised nuclear devices Radiation sciences facility and regulatory update: providing radiation sources, precise measurement of dose delivered (dosimetry), radiation safety program, and training 1. Small Animal Radiation Research Platform (SARRP) – 0.4mm x-ray beam a. On line now 2. Linear Accelerator/CT facility a. Damage to ceiling scheduled for repair in FY15 b. Commissioning starting in September 2014 3. Control console replacement for research reactor (TRIGA) and cobalt irradiator a. Cobalt irradiator – September to December 2015 (to give researchers lead time) b. TRIGA; 2016/17 4. Panoramic Cobalt Irradiator refueling completed July 2014 5. Chronic Low Level Irradiation Facility: low level facility remains to be refueled (2016/17, but already funded) – and will be redesigned so that a range of low dose rates can be maintained for a longer period 6. Ongoing Nuclear Regulatory Agency activities a. Relicensing the Training, Research, Isotope General Atomics reactor (pending) b. Broad scope license (radionuclide use at AFRRI), will be submitted November 2014 c. Cobalt facility: complete 7. Staffing a. Physicist/engineer to operate and maintain the SARRP and LINAC; assist in the development to improve dose measurement methods b. Assistant Radiation Safety Officer; augment junior military technical staff, provide continuity of operations and cover more sources Scientific research: 1. Move AFRRI radiation countermeasures into advanced development and through FDA certification – this is a continued emphasis a. AFRRI is participating in a Technology Readiness Level Assessment October 2014 b. Force Health Protection and Readiness also advocating for advanced development funding 2. AFRRI is under increasing pressure to perform advanced drug development in large animal models because of availability of funds from other agencies. This is resource intensive for veterinary support. Good Laboratory Practices (GLP) Program: 1. Advances research of our drug candidates (but AFRRI efforts alone will not be sufficient for FDA licensure) 2. Funding: Biomedical Advanced Research and Development Authority (BARDA) until Q2 FY15. Then, $3.5M from the Defense Health Agency to continue GLP program for 4 years 3. Veterinary Sciences personnel will take over quality control function from core GLP staff, QA (core GLP position) will provide oversight and monitoring 4. GLP “practice” studies projected: a. Mouse study starting about Nov 2014 b. NHP and minipig studies about Jan 2015 c. BARDA will closely monitor the large animal studies 5. National Institute of Allergy and Infectious Diseases (NIAID) is funding an independent GLP audit 14-15 Oct 2014 October 2014 TAB 25 F. Edward Hébert School of Medicine Report Uniformed Services University of the Health Sciences Board of Regents Board Brief Submitted by: Art Kellermann, MD, MPH Date: September 5, 2014 Title & Department: Dean, School of Medicine Phone 301-295-3016 Purpose: Information X Action Subject: Dean’s Report: School of Medicine (SOM) Achievements Welcome to Bushmaster! Medical Field Practicum 202, long known as “Bushmaster”, is the capstone experience for senior medical students in the School of Medicine (SOM) as well as select graduate nursing students, dental students and graduate students in Medical and Clinical Psychology at USU. It is the final MFP in a series of four that are conducted throughout the SOM’s four year curriculum: the first two are taught in the 18 month pre-clerkship phase of Military Medical Practice & Leadership (MMP&L)—MFP 101 and 102—and the last two. — MFP 201 and 202.—are held in the final 18 month post-clerkship phase as part of Advanced MMP&L. “Bushmaster” is distinguished from the other MFPs as well as anything experienced in other medical schools by the combination of training, formative and summative evaluations of senior students in the three major elements of USU’s unique military medical program of instruction: Military Medical Practice, Pre-Hospital Trauma Life Support/Combat Medical Skills and Leadership. A slightly more detailed overview of the exercise, including recent changes to its objectives, is attached at the end of this report (see Attachment 1). USU signs historic MOU with the NHLBI: Jointly signed by USU President Rice and NHLBI director Gary Gibbons, MD, this MOU establishes and recognizes the “enduring nature of the broad scientific, policy and operational goals and objectives of the Collaborative Health Initiative Research Program.” The goal of the MOU is to identify, develop and conduct collaborative research in areas of USU strength that will generate findings that advance our understanding and treatment of heart, lung, blood and sleep disorders of importance to the U.S. military and civilian medicine. Dr. Harvey Pollard, Chair of the Department of Anatomy, Physiology and Genetics has agreed to lead USU’s team, and Dr. David Scott, Vice Chair for Research in the Department of Medicine will serve as Associate Director. Funds will be administered by HJF. The first project supported by this MOU is led by Drs. Patricia Deuster and COL Frances O’Connor of the Department of Military and Emergency Medicine. It will explore the association between sickle cell trait exertional injuries and sudden death, with the goal of identifying important genotypes and phenotypes that might point to an increased or reduced risk of adverse outcomes. October 2014 The Enlisted to Medical Degree Preparatory Program (EMDP2) begins: The initial group of 5 Army and 5 Air Force students have started classes at the George Mason University’s Prince William Campus in Manassas, VA. The students represent air traffic controllers, laboratory technicians, and Special Forces medics, and come from many different walks of life. They would like to offer a personal thank-you to the Board of Regents for the Board’s tremendous support of the program. The US Navy and Marine Corps hope to add enlisted students to the program starting in 2015. WRNMMC & USU are achieving “Unity of Effort” in multiple areas of joint endeavor:: Accomplishments in the last quarter include: a) crafting a shared vision for the future of the Murtha Cancer Center, b) the appointment of Dr. Paul Pasquina, Chair of USU’s Department of Physical Medicine and Rehabilitation to coordinate TBI-related activities between WRNMMC and the National Intrepid Center of Excellence (NICoE); c) harmonization of key elements of IRB process and procedures between USU and WRNMMC; d) pursuit of joint accreditation of Simulation in Healthcare activities at USU, WRNMMC and FBCH; e) an agreement to jointly support activities that will enhance fitness and readiness, and f) joint recruitment of the next Chairman of the Department of Pathology at USU, who will also serve as Chief of Pathology at WRNMMC and work closely with the Joint Pathology Center (JPC). Infectious Diseases Clinical Research Program (IDCRP) receives a highly favorable external review. Recently, a high-level panel led by LTG (ret) James Peake, MD, reviewed the research productivity and overall management of the IDCRP. This panel consisted of 5 senior clinician-administrators with extensive experience in infectious diseases, multicenter clinical research networks, executive management, regulatory affairs, military medicine, and graduate medical education. The panel’s report praised the IDCRP for making impressive strides since its last review in 2010. Since that time the IDCRP has achieved sustained productivity in the conduct of militarily-relevant clinical research, published important findings in high-quality journals, and used these findings to inform MHS policy. The panel notes that this USU-based clinical research model, which draws its support from the Henry M. Jackson Foundation and leverages a centralized IRB, could serve as a conceptual model that other MHS clinical research networks could follow. In fact, the panel supports centralizing the coordination and conduct of MHS multicenter collaborative clinical research at the University. Congress reprograms funds to enable the DoD to support 4 vital USU research programs. Thanks to the strong support of ASD(HA) Dr. Woodson, his staff and USU’s Office of Finance, the School of Medicine expects to receive more than $100 million in reprogrammed Defense Health Program funds to enhance four SOM projects of vital importance to the nation and sustain them for several years: • Army STARRS ($31.9M) – The funding will enable long-term follow-up of the existing Army STARRS sample and should be of great value to increase our understanding of the patterns and predictors of the range of positive and negative mental health and behavioral outcomes observed in the course of military service. Follow-on study will improve early October 2014 detection, and effective prevention and treatment of suicide, PTSD, TBI, and comorbidities. Because of its cutting edge procedures, sampling and analyses, this increased level of effort will leverage existing and emerging technologies to improve existing health care for warfighters and others. It will also enable ongoing and new analyses of: 1) existing and emerging data from the study; and 2) new findings regarding diagnostics, therapeutics and outcome measures for PTSD, TBI, related injuries and other disorders. • Center for Rehabilitative Sciences Research ($10.5M) – The new funding will provide for the advancement of rehabilitative care for Service members with combat related injuries, particularly those with orthopedic trauma, limb loss and neurological complications. Increased level of effort will promote the recovery of injured Service members, emphasizing return to duty and successful community reintegration. Increased level of effort will include: 1) Existing Barriers to Successful Reintegration, 2) Improvements to Pain Management Strategies, 3) Use of New Technologies to Advance Rehabilitation and Measure Performance, and 4) Use of New Technology or Novel Interventions to Improve Functionality. Increased level of effort will determine factors that influence successful reintegration of injured Service members and develop new technology/treatment interventions to mitigate barriers. • Surgical Critical Care Outcomes Improvement for Wounded Service Members-SC2i ($45.7M) - Funding will increase level of effort to develop individualized treatment and decision algorithms (Clinical Decision Support Tools - CDS) that are based on the underlying biology of physiologic compensation to injury, with the ultimate goal of improving outcomes while reducing costs of care of wounded, ill, and injured military personnel. The increased level of effort this funding provides will accelerate transfer into medical practice of biomarker-based decision-making in critically ill military surgical patients. • Infectious Disease Clinical Research Program-IDCRP ($18.3M) Funding will increase the IDCRP’s level of effort in translational research on militarily relevant infectious diseases (ID) within the MHS. Increased the baseline level of effort beyond that provided by the NIAID will allow for greater access to large patient populations from the worldwide network of Military Treatment Facilities (MTFs). The IDCRP's current portfolio is executed in over ten MTFs. It includes 51 protocols in the fields of trauma infection, HIV, respiratory infection, skin/soft tissue infection, travel/deployment-related infection, and sexually transmitted disease. The Val G. Hemming Simulation Center’s growing impact - The Hemming Simulation Center is seeking re-accreditation by the American College of Surgeons (ACS) for a third consecutive cycle. It was recently one of 5 centers nationwide to successfully achieve the ACS's designation as an accredited site for simulation fellowship training. The Sim Center is also seeking a second accreditation by the Society for Simulation in Healthcare in partnership with the WR-B and FBCH simulation sites, representing a true collaborative joint venture. The Center October 2014 continues to attract new learners to its “Wide Area Virtual Environment” (WAVE) facility including the Capitol Hill Medical group, the US Air Force medical group at Joint Base Bolling- Anacostia and USU students during their emergency medicine rotation. Center for Deployment Psychology launches an online “Military Culture” course for healthcare professionals (a joint effort with DVA). The course can be found at http://www.deploymentpsych.org/military-culture The National Center for Disaster Medicine and Public Health hosts second annual “Learning in Disaster Health” Workshop at the Fort Myer Officer’s Club on 9-10 Sept 2014. This unique national workshop intentionally fosters an interdisciplinary learning environment that focuses on the unique challenges of disaster health education and training. A report on the meeting will be published in a professional journal. Academic Affairs Updates: • Honor Code Update: o The Honor Representatives and Student Leadership of the USUHS SOM Classes of 2014, 2015, 2016 and 2017 led a University wide discussion of Honor and Academic Integrity. Their goal was to make the code 1) applicable to all schools at the University; 2) more readily recalled and internalized; and 3) one that students would take an active role in (particularly with regard to education and culture). After consultation with the service academies and other medical schools with honor codes, the students proposed the following: "We will not lie, cheat, or steal, nor do we tolerate those who do." In addition, they embraced the concept "Observe, Confront, Report." They have designed a process that embraces these concepts at the student level, and have spent a great deal of time and energy educating their peers. The new Honor Code and System have been adopted in the SOM for both medical and graduate students. The other Schools of the University are currently reviewing the code and considering it for adoption (see Attachment 2). • Admissions: o The Class of 2018 matriculates! The 171 students in the Class of 2018 represent 36 states and the District of Columbia. Ten percent are prior enlisted and 10% are students from groups that are under-represented in medicine – a marked increase from the average number of under-represented minority students recruited per year over the past decade. Nineteen percent (19%) are first generation to college students. The average GPA is 3.6 and the average MCAT score is 31.7. o Interviews for the class of 2019 have begun! As of September 3, USUHS has received 2,277 verified applications. We did not receive the same quantity of October 2014 applications until October 25 during the last cycle. At this pace we could potentially exceed 3000 applications this year, a benchmark last achieved in 1997. • Medical Education: o Class of 2015: Typically, after a medical school reforms its curriculum, performance on the USMLE exam declines as faculty and students adapt to the new changes. The Class of 2015 defied conventional wisdom by setting a new standard for performance on the USMLE Step 1 and Step 2-clincal exams. Their Step 1 pass rate was greater than 99% on the first attempt, and all students have subsequently passed, with average scores that are appreciably higher than the national average and 20 points above USU’s historical mean. To date, more than 80% of class members have received their USMLE Step 2c scores. As was true with Step 1, the class pass rate exceeds 99% and the average score is again around 20 points higher than our school’s historical mean. We could not be prouder of these students. The class of 2015 will complete their first six post-clerkship rotations this month, and all recently completed their “audition” rounds for residency positions. They are currently in the thick of GME applications. They return to campus the first week of October to study military contingency medicine, culminating with the Bushmaster field exercise. o Class of 2016: The Class of 2016 just completed their second full clerkship block. Unsolicited feedback from our national faculty is full of praise about how strong our clinical students are on their rotations. They consistently perform above the level expected for their training. We’ve received similar feedback from the Washington DC VA and other hospitals where our students work next to GWU and Georgetown medical students. Our Office of Student Affairs has begun post-clerkship planning and the students are beginning to map out their courses of study for their last 18 months. This class will have a full 6 weeks of Step 1 preparation. We will closely track any students felt to be at risk of a low score. o Class of 2017: Following their break, the Class of 2017 is back in the swing of things with module #6, “Reproduction/Endocrinology.” In August, all completed a wide variety of summer experiences and Medical Field Practicum102, culminating with the Antietam Medical Staff Walk. This class was instrumental in helping the SOM Office of Student Affairs orient the class of 2018. They have received their clerkship schedules and are beginning to accomplish necessary training in the use of the MHS EMR and the technical aspects of booking travel to their clinical rotations at national MTFs. o Class of 2018: The Class of 2018 hit the ground running. They will be conducting elections for their class officers after their first midterm, which is about three weeks from the filing date of this report. The Office of Student Affairs is also starting the process of interviewing each student regarding their transition to USU and their progress thus far. Several members of this class started a new USU tradition. Desiring a more formal ceremony to mark their transition into uniform, these students worked with the Brigade and Commandant, School of Medicine to organize a commissioning October 2014 ceremony on 29 August 2014. Forty new medical students from the Army, Navy, Air Force and Public Health Service participated. Colonel Kevin Glasz, USU Brigade Commander, presided over the ceremony and LTG (ret) Eric Schoomaker was the guest speaker. Faculty, staff and family members attended to show their support. Dean’s Office Updates: • Dr. Greg Mueller, a highly-regarded professor in the Department of Anatomy, Physiology and Genetics, has stepped up to take on the role of Acting Associate Dean of the Office of Graduate Education (GEO). He is being supported by two capable and respected Assistant Deans: Professor Brian Cox, former Chair of the Department of Pharmacology, and Dr. David Cruess, Vice Chair of the Department of Preventive Medicine and Biometrics and director of PMB’s graduate programs. Janet Anastasi, who previously worked in the GEO office, has come out of retirement temporarily to assist with program administration. A decision about permanent leadership of GEO will be made in the very near future. • Dr. Martin Ottolini, Director of the SOM’s new Capstone Program, is phasing the program in as an advanced elective with the goal of eventually integrating it as part of the post-clerkship educational experience for all USU medical students. More than 30 members of the class of 2015 have begun their independent projects. At least as many students from the class of 2016 have expressed an interest in taking on a Capstone project, and are started to plan their activities. • COL Jeffrey Hutchinson Associate Dean for Clinical Affairs taught at the AAMC’s annual Minority Faculty Development Workshop in Vancouver, British Columbia, Sept 6-8. He was joined by LTC Terrill Tops (PAT) one of the SOM’s best young educators. • CAPT (ret) Jerri Curtis retired from the military this past spring after a distinguished 30 year career as a Navy Medical Corps officer. Following a “mini-sabbatical” of sorts, she returned to USU in August in a civilian capacity as our new, permanent Associate Dean for Graduate Medical Education and Designated Institutional Official (DIO) for the National Capitol Consortium, which coordinates military GME programs in the National Capitol Region. Challenges: • The LCME will visit USU in late October 2015. Shortly following completion of the 2015 iteration of Bushmaster, the LCME will bring a team of surveyors to USU to evaluate the adequacy of our academic resources, curriculum, instruction, governance, scholarship and other elements. A successful site visit cannot be taken for granted. Several well-known Schools of Medicine, most notably Baylor, recently fared poorly when visited by the LCME. We are determined to avoid a similar fate. We have already completed substantial preparatory work, and the successful implementation of our new reformed curriculum has provided the faculty with a boost. On September 11, the School October 2014 will formally launch the reaccreditation effort by rolling out committee assignments, the work plan and related expectations. Although it will require an “All of School” effort, any effort this complex requires highly capable leadership. We are fortunate to have Dr. William (Bill) Gilliland, Associate Dean for Medical Education, on our team. He is receiving strong support from Dr. Brian Reamy, Senior Associate Dean for Academic Affairs. • USU’s Graduate Education program faces multiple challenges. USU’s interdisciplinary doctorate and post-doc programs in Neuroscience, Emerging Infectious Diseases and Cell Biology learn from, work with and support USU faculty members who are generating high impact science that advances military health, medicine and global health security. These basic science programs are not only valuable for the research they generate; they are also essential to the education (and accreditation) of USU’s medical student training program, as well as the GSN, PDC, and public health and clinical psychology training programs. The vast majority of USU PhD graduates take positions with federal research labs in the National Capitol Region and other parts of the country. Unfortunately, because the legislation that established USU did not recognize that PhD training is an essential aspect of medical school operations, the status of these students at USU is unclear. This not only undermines student morale, it requires the University to go to elaborate lengths to ensure that they have a reasonably supportive environment to learn, teach and develop their research skills. A solution is urgently needed to assure the long term stability of graduate student education at USU. News: • The Center for Neuroscience and Regenerative Medicine (CNRM) has been selected as a finalist for the 7th Annual Major Jonathan Letterman Award for Medical Excellence. Ten finalists will be recognized at this year’s dinner, and two will be selected to receive the 7th Annual Major Jonathan Letterman Award for Medical Excellence. One award will be presented to an individual and one will be presented to an organization or project. CNRM is nominated in the organization category. • (PAT) Dr. Robert Friedman, who has led the Department of Pathology for more than 3 decades, stepped down as Chair on June 30. He will formally retire from USU on December 31, but intends to continue conducting lab research on a volunteer basis. • (OBG) RADM (ret) William H.J. Haffner received the Association of Professors of Gynecology and Obstetrics Lifetime Achievement Award. • (OSA) Two members of the School of Medicine Class of 2015, Air Force 2nd Lt Philip Matthews and Army 2LT Christopher Stark, presented their Capstone Program research at the First Annual Pediatric Medical Student Research Forum, an academic meeting held in Orlando, Fla., August 29-31, 2014. October 2014 • (ANE) CAPT Dale Szpisjak (ANE) and Dr. John Capacchione will soon execute a CRADA regarding a brain cooling device. • (MEM) Dr. Patricia Deuster and COL Frances O'Connor were keynote speakers at the 3rd International Congress on Soldier Physical Performance • (MIC) In late May, Department Chair Alison O’Brien, Ph.D. organized a department research retreat, which was funded by USU and HJF technology transfer and sponsored projects awards. Oral and poster presentations were given by 23 postdoctoral fellows, 10 graduate students, and 2 research technicians. The Keynote Speaker was Dr. Christopher Broder, who presented a captivating seminar about his development of a vaccine and a therapeutic to treat the deadly Hendra virus. Other highlights included extensive interactions among MIC faculty, students, and postdocs; establishment of collaborations; and involvement of medical students who spent time in MIC research labs over the summer. • (MIC) Joseph Mattapallil, Ph.D. was appointed as a Standing/Chartered member in the AIDS Immunology and Pathogenesis (AIP) Study Section at CSR for the term effective from July 1, 2014 to June 30, 2020. Study sections review grant applications submitted to the NIH, make recommendations on these applications to the appropriate NIH national advisory council or board, and survey the status of research in their fields of science. These functions are of great value to medical and allied research in this country. Members are selected on the basis of their demonstrated competence and achievement in their scientific discipline as evidenced by the quality of research accomplishments, publications in scientific journals, and other significant scientific honors. • (MIC) Edward Mitre, M.D. has been invited by the Infectious Diseases Society of America to help formulate a Maintenance of Certification module for the American Board of Internal Medicine. As the module is on tropical infectious diseases, the invitation recognizes the expertise Dr. Mitre and USUHS have in the field of tropical medicine. • (APG) Sharon Juliano, Ph.D., director of the Interdisciplinary neuroscience program, recently published a high-impact paper, entitled "ASIC1a Activation Enhances Inhibition in the Basolateral Amygdala and Reduces Anxiety" in The Journal of Neuroscience. The article has generated a lot of interest in the scientific community. ScienceDaily, one of the Internet's most popular science news web sites with more than 3 million monthly visitors, recently reprinted a press release issued by the Society for Neuroscience http://www.sciencedaily.com/releases/2014/02/140225193239.htm. • (PAT): A US Department of Energy (DOE) pilot project directed by Dr. Michael Daly has been upgraded to ‘full project status’. It is exploring techniques to promote bioremediation of acidic, high-temperature radioactive waste sites leftover from the Cold War. Funding has been set at $450K per year. October 2014 • (PAT): A Defense Threat Reduction Agency (DTRA) funded collaborative project involving Dr. Radha Maheshwari (PAT), Dr. Michael Daly (PAT), and Dr. Juliann Kiang (AFRRI) has been established to test the radioprotective efficacy in mice of a synthetic Mn-antioxidant peptide. It is based on new insights implicating the proteome as the critical target in irradiated cells. The Mn-antioxidant peptide was developed by Dr. Daly's group at USU, which has been studying the molecular basis of extreme radiation resistance in the bacterium Deinococcus radiodurans since 1992. • (PAT) Dr. Robert Friedman and Dr. Sara Contente are following a lead on a previously-undescribed mechanism of action by interferon. They have observed that HRAS-transformed cells can be reverted to non-malignant status by treatment with interferon beta. This appears to be due to the induction of the production of the pro- enzyme for lysly oxidase in the reverted population of cells. This induction is in turn due to an extensive methylation of many DNA sites by the interferon treatment. The transformed state of the cells can be reintroduced by treatment with azacytidine, a demethylating agent. • (MED) Dr. Charlie Magee was deployed to Afghanistan in support of OEF • (MED) Research conducted by Dr. Brian Hemann was selected for oral presentation at annual Academic Internal Medicine Week annual conference. It is entitled, "The Association of Poor Internship Performance with Students Requiring Remediation in the Internal Medicine Clerkship". Dr. Monica Yepes-Rios (MED) abstract "Progression of Communication Skills in the PreClerkship: Is student performance improved with a modular curriculum?" was also selected. This means USU has 2 of the 5 oral abstracts that will be presented at this prestigious annual gathering of Chairs of Medicine and internal medicine educators for undergraduate and GME at US and Canadian medical schools. • (MED) Dr. Bill Kelly won the 2014 Distinguished Service Award from the American College of Chest Physician. • (MED) Dr. David Scott received an NIH grant ($378,675) to develop novel approaches to induce immune tolerance to clotting Factor VIII, a major obstacle to effective treatment of bleeding due to hemophilia. • (MED) Ms. Erin Quiko, Administrator, USUHS clerkships at Naval Medical Center San Diego was named USU’s “Senior Employee of the Quarter”. • (MED) Dr. Todd Gleeson has been named 2014 USUHS Faculty Member of the Year and Mentor of the Year by WRNMMC’s Internal Medicine Residency housestaff. Dr. Brian Neubauer was elected by the Class of 2016 as one of two “Module Directors of the Year” October 2014 • (OBG) Dr. Christopher Zahn, Department Chair, has secured a multi-institutional research grant to investigate health literacy and numeracy in pregnancy-related diabetes. The research will be conducted in collaboration with Northwestern University. Approximate amount: $200,000. • (OBG/SIM) Dr. Shad Deering, Deputy Director of the Val Hemming Simulation Center, has been tasked by Dr. Woodson to head a working group to develop a strategic plan for simulation across the MHS. • (PED/SIM) Dr. Joe Lopreiato, the Center’s director, has been appointed to the Board of Directors of the Society for Simulation in Healthcare in part for his work in developing a global dictionary of simulation terminology. • (OBG) COL Ernest Lockrow and COL Shad Deering conducted the first ‘Teach the Teacher’ Course for simulation in obstetrics and gynecology attended by senior leaders of the American College of Obstetricians and Gynecologists (course developed and implemented by Drs. Ernest Lockrow and Shad Deering). October 2014 Attachment 1 An Overview of “Bushmaster” (MFP 202) “Bushmaster”, or Medical Field Practicum 202 (MFP 202), is the capstone military medical experience for senior medical students in the School of Medicine (SOM) as well as select graduate nursing students, dental students and graduate students in Medical and Clinical Psychology (MPS) at USU. It is the final MFP in a series of four that are conducted throughout the four year SOM curriculum: two are in the 18 month pre-clerkship phase of Military Medical Practice & Leadership (MMP&L)—MFP 101 and 102—and two are held in the final 18 months of the post-clerkship phase of Advanced MMP&L—MFP 201 and 202. “Bushmaster” is distinguished by the combination of training, formative and summative evaluations of senior students in the three major elements of the military medical program of instruction (MMP&L and Advanced MMP&L): Military Medical Practice, Pre-Hospital Trauma Life Support/Combat Medical Skills and Leadership. Over the past year and a half, the Department of Military and Emergency Medicine (MEM), under the guidance of the SOM Dean and in partnership with faculty from the other SOM and GSN departments, has been refining the lectures, small group workshops and labs, and medical field practicums that constitute the military medical curriculum into a coherent program of instruction with a progressive training and education of key professional topics (e.g., leadership, medical history), technical skills (e.g., Basic Life Support, Advanced Cardiac and Trauma Life Support, Tactical Combat Casualty Care, bedside ultrasound) and administrative orientation so as to ensure a fully capable uniformed medical officer upon graduation. Material for this POI is woven throughout the four year SOM curriculum from the first week of classroom instruction to graduation by three principal means: material fully integrated into the seven pre- clerkship modules when appropriate to complement the basic material (e.g., heat and cold stress into the Musculo-Skeletal Module or exercise and stress-related nutrition into the Reproduction & Endocrine Module), as “blocks” of instruction in the first and mid-week of each module (e.g., leadership series) or in medical field practicums conducted either on-site at the USU campus (MFP 102 and 201) or at Fort Indiantown Gap (MFP 101 and 202). “Bushmaster” harvests lessons learned and topics covered throughout the previous 3-1/2 years of medical school into one highly intense, operationally realistic period of scenario-based evaluable events in the field. Students exercise their technical skills, are rotated through a series of leadership roles and are challenged with environmental factors (e.g. heat and cold, night and day, rain and fog), personal limitations (e.g. physical, mental and emotional fatigue) unpredictable, even chaotic operational tasks, and time and resource limitations, all under notionally life-threatening conditions. In addition to the improved coherence of MFP 202 in the MMP&L Program of Instruction, the 2014 Bushmaster exercise will feature several innovations. The exercise will leverage continued USUHS faculty role-play as casualties. This was a requirement for the spring Bushmaster exercise for the class of 2014 secondary to a limited number of first year students to serve as casualties (MFP 101) for the off-cycle Bushmaster; it was a great success and will October 2014 continue to offer this experience. This will also be the first Bushmaster that we will introduce Individual First Aid Kits (IFAKs) to the point of injury lanes. The casualties will wear IFAKs and students will be expected to recognize them and utilize the casualties’ equipment before using gear from their individual medic bag; this is a lesson translated from the success on the current battlefield in the Middle East. We will have a record number of foreign medical students in attendance (13), and for the first time will have the participation of 2 postgraduate dental students. Finally, this will be the first time that MEM will serially execute MFP 202-first iteration, followed by MEM 101 for the class of 2018, followed by MFP 202-second iteration. The end result is a ‘living classroom” trial and testing ground for the soon-to-be- graduates that solidifies their roles as new uniformed medical officers and builds their confidence in the four years of education and training they have received. October 2014 Attachment 2 The Importance of Honor and Integrity in the Hébert School of Medicine, Uniformed Services University of the Health Sciences ______ Education at the F. Edward Hébert School of Medicine is built on a foundation of integrity and honor. These qualities are not only essential for physicians; they are equally important for military officers. The school embraces these values in a number of ways: • At three points during the USU medical student education, students swear the Hippocratic Oath, which states, among other things, that “I will lead my life and practice my art in uprightness and honor.” • In the most recent edition of the Medical Student Handbook (2013-2014), page 24, “The Honor System and Your Personal Integrity”, students were introduced to a simple code:1 In my profession and in my life, I will be an honorable, sensitive and forthright person, dedicated to the highest standards of integrity and ethical behavior. I will not tolerate any form of dishonesty, unethical behavior, or corruption in myself or others.” • On the urging of our students, led by the Class of 2016 and the Honor Representatives of all current classes, our new Medical Student Handbook (2014-2015) will contain an even simpler code:2 “We do not lie, cheat, or steal, nor do we tolerate those who do.” • The Hébert School of Medicine’s Student Promotions Committee (SPC) is the official School of Medicine body that “reviews matters of serious concern for violations of personal integrity and professional comportment…” The policies of the SPC are outlined in detail in USUHS SOM-DPM-004-2014, which was last updated on 9 June 2014. According to this instruction: “Academic integrity is required of every medical student and is part of non- cognitive academic performance. Medical students who violate academic integrity are subject to disenrollment even though they are otherwise in good academic standing.” • In the lobby of our A Building, the Uniformed Services University displays a framed set of documents that describe USU’s vision, mission and values. The first of the University’s 7 values is “Courage and Integrity” “We foster a culture of academic, physical and moral courage in all our graduates, faculty and leaders, and we are uncompromising in our adherence to the highest standards of intellectual and personal integrity” Our institution’s core values are echoed in the core values of the four Uniformed Services we support and in which our students serve: October 2014 1. The U.S. Army espouses 7 core values. One of them is integrity:3 “Do what’s right, legally and morally. Integrity is a quality you develop by adhering to moral principles. It requires that you do and say nothing that deceives others. As your integrity grows, so does the trust others place in you. The more choices you make based on integrity, the more this highly prized value will affect your relationships with family and friends, and, finally, the fundamental acceptance of yourself.” 2. The U.S. Navy has 3 core values. One of them is honor:4 "I will bear true faith and allegiance ..." Accordingly, we will: Conduct ourselves in the highest ethical manner in all relationships with peers, superiors and subordinates; Be honest and truthful in our dealings with each other, and with those outside the Navy; Be willing to make honest recommendations and accept those of junior personnel; Encourage new ideas and deliver the bad news, even when it is unpopular; Abide by an uncompromising code of integrity, taking responsibility for our actions and keeping our word; Fulfill or exceed our legal and ethical responsibilities in our public and personal lives twenty-four hours a day. Illegal or improper behavior or even the appearance of such behavior will not be tolerated. We are accountable for our professional and personal behavior. We will be mindful of the privilege to serve our fellow Americans.” 3. The U.S. Air Force also has 3 core values, starting with Integrity First:5 “The Airman is a person of integrity, courage and conviction. Integrity is a character trait. It is the willingness to do what is right even when no one is looking. It is the moral compass, the inner voice, the voice of self-control and the basis for the trust imperative in today's military. Integrity is the ability to hold together and properly regulate all of the elements of a personality. A person of integrity, for example, is capable of acting on conviction. A person of integrity can control impulses and appetites.” But integrity also covers several other moral traits indispensable to national service: Courage, Honesty, Responsibility, Accountability, Justice, Openness, Self-respect, and Humility 4. The U.S. Public Health Service lists 4 core values. One of them is integrity: 6 “Exemplifies uncompromising ethical conduct and maintains the highest standards of responsibility and accountability.” Integrity and honor are not abstract ideas that can be embraced when easy to do so and ignored when it is not. As core values, they must guide our decisions and actions in the most October 2014 trying of circumstances. To date, more than 5,000 graduates of “America’s Medical School” have lived up to these values. Their example sets a high standard for us to follow. We, the faculty, students and staff of the F. Edward Hébert School of Medicine at the Uniformed Services University of the Health Sciences—“America’s Medical School”—must honor their example by maintaining this high standard for those who come behind us. The citizens of our nation, and those who go in harm’s way to defend it, deserve no less. References 1 Medical Student Handbook: 2013-2014. F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences. Bethesda, MD. 2013. Pg. 24. 2 Medical Student Handbook: 2014-2015. F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences. Bethesda, MD. 2013. Pg. XX. 3 http://www.army.mil/values/ 4 http://www.navy.mil/navydata/nav_legacy.asp?id=193 5 http://www.airforce.com/learn-about/our-values/ 6 http://www.usphs.gov/aboutus/mission.aspx October 2014 TAB 26 F. Edward Hébert School of Medicine Graduate Education Report Uniformed Services University of the Health Sciences Board of Regents Board Brief Submitted by: Gregory P. Mueller, Ph.D. Date: Sept. 5, 2014 Title & Department: Associate Dean for Graduate Education (Acting) Phone: 295-9474 Purpose: Information X Action Subject: SOM Office of Graduate Education and Graduate Programs Enrollment Statistics The USU School of Medicine (SOM) Graduate Programs recruitment and application cycle for Summer/Fall 2014 matriculation is complete. Data on accepted offers and on matriculating students follows. • As of 15 August 2014, the close of the 2014 admission cycle, the SOM Graduate Programs have enrolled a total of 60 new students. There are 19 new doctoral students (17 PhD and 2 DrPH students) and 41 master's students. A total of 41 of the master’s students are enrolled in programs of the Department of Preventive Medicine and Biometrics master’s programs: 9 MSPH students, 22 MPH students, 8 MHAP students and 2 MTM&H students. There are 6 doctoral students enrolled in one of the three programs of the Department of Medical and Clinical Psychology: 6 CPS students (0 MPS students, and 0 MCP students). These individuals will complete a master’s degree as part of their PhD program and accordingly are training in an MS/PhD track. • The total number of offers made this year for admission into USU doctoral and master’s programs were 49 and 75, respectively. Total numbers of applications, offers, declinations and acceptances for this year are consistent with the statistics and trends for last year. The overall number of applications received was up from 534 for 2013 to 593 for 2014. The proportion of women (49%) and under represented minorities (24%) applying this year was not appreciably different from the applicant pool of last year (53% and 21% respectively), • The total number of matriculants this year, 60, is down from the 76 students that were enrolled in August 2013. Reasons include a late decision to suspend admission of international graduate students and a requested reduction in civilian admissions into the graduate programs of the Department of Medical and Clinical Psychology. October 2014 • The Graduate Education Office is now receiving a steady stream of applications for graduate study beginning in 2015. The numbers closely approximate those received last year at this time. The deadline for application receipt has been advanced this year from 1 January to 1 December. This will allow the GEO time to process and distribute the applications in advance of the December holiday season. Graduate Education Office: Dr. Gregory Mueller and Drs. David Cruess and Brian Cox continue to serve as Acting Associate Dean and Acting Assistant Deans, respectively, since 1 June 2014. This new structure continues to support the normal operations of the GEO while permitting Dean Kellermann adequate time to identify a permanent Associate Dean for Graduate Education. The new management team is working to reorganize the staffing of the GEO to establish a deputy (GS 9-12) and an assistant (GS 7-9) to the Associate Dean. This staffing will provide for a high level of sustained service and thus enable the new permanent dean the opportunity to focus his/her efforts on important programmatic initiatives. Recent Actions and Initiatives: • The GEO, Dean and President have worked with Henry Jackson personnel to negotiate the acquisition of health insurance coverage for our civilian graduate students from a new provider. Despite the last minute urgency to accomplish this task, due to cancellation of coverage by our previous provider, the transition has occurred without major disruption. Nevertheless, the process has imparted some stress on a number of students highlighting the need for the GEO to improve its communications with the student body during uncertain times. • The GEO is working with the Division of Employee Training and Development of the Food and Drug Administration and the Wounded Warrior Transition Program of the Walter Reed National Military Medical Center to identify opportunities where USU graduate students may gain teaching experience through the offering of formal educational presentations including seminars, lectures, short courses and hands-on lab experiences. Ongoing Matters from the July Update: Challenges and Potential Solutions: The new leadership of the School of Medicine Graduate Education Program will confront a number of challenges over the coming years. These on-going challenges were presented in the July BOR update and are summarized and updated briefly here: • Long-term sustainability of stipend support: The SOM Graduate Programs offer 3 years of appropriated stipend support to civilian doctoral students at levels which have remained constant for the past five years. The current level of appropriated support for incoming students, fall 2014, remains at $25,000. This amount is increased by USU’s Endowment for Graduate Education to $27,000 for students in their first 2 years of training and $28,000 for doctoral students who have been advanced to candidacy (year 3). October 2014 At present, there is no mechanism to replace the dwindling endowment funds. Accordingly, the long-term sustainability of graduate student stipends at a level that is competitive with stipends offered at area schools is in serious doubt. Potential solutions: Increase appropriated funding available for USU graduate student stipends, to a competitive level and seek an increase in the Graduate Education Endowment funding to a level that is self-sustaining through interest income. Without some adjustment, a reduction in the number of stipends offered may become necessary, but this will impair the future viability of the program, as well as increasing overall education costs per student. The GEO is initiating discussions with the faculty and administrative leaders to identify mechanisms for preserving and replenishing the Endowment Fund. • The high and rising cost of health insurance for civilian graduate students: Because many of our graduate students are neither uniformed personnel nor U.S. government employees, we are obliged to provide them with access to health insurance. Currently premiums for civilian graduate students come out of our limited and declining Graduate Education Endowment fund, which is managed at the Jackson Foundation. These costs impose the single largest burden on the Endowment Fund amounting to approximately $.5M annually. At our current rate of utilization, the Endowment Fund, which currently amounts to ~$8.2M, will be fully expended within 5 years. Potential solutions: As noted above, the GEO is beginning to work with the faculty and administrative leaders to identify mechanisms for preserving and replenishing the endowment fund. Separately, we are exploring alternative solutions for obtaining student health insurance for future years. These include the possibility of using the health care exchanges. In this event, we will seek to offset the costs incurred by the students by increasing their stipends with funds from the endowment, although increasing the stipend will reduce the small premium subsidy for which the students are eligible under the Affordable Care Act. Increasing the stipend will, of course, maintain the burden on the endowment, but failure to offer health insurance to students will significantly reduce our ability to recruit the best students to the program. • Severe constraints on recruitment of foreign graduate students: Current DoD instructions preclude USU from admitting any graduate student who does not hold a Bachelor’s degree from an accredited university or college within the US, Puerto Rico, Canada or Guam. Over time, if this policy remains unaltered, the absence of even a small number of foreign students at USU will weaken the academic environment, reduce the total number of qualified applicants to our program, and limit our role in advancing global health engagement in allied nations. Potential solutions: Seek a clarification of the legal issues concerning the recruitment of international students, and if necessary, obtain a revision/exception to the guidance that currently prohibits their recruitment. Additionally, recruiting efforts may be targeted to October 2014 international candidates who meet the Baccalaureate requirement, as well as international students who have strong ties to DoD laboratories in their home country, or whose matriculation here will be useful to the health engagement efforts of regional COCOMs. • Justification for a USU Civilian Graduate Program: Although many if not most of our civilian graduates take important jobs in federal research, management, or oversight and compliance after graduation, there is no formal requirement for federal service after graduation. The lack of an explicit teaching obligation for graduate students while at USU, and the absence of a "payback" requirement have been raised as potential problem for the long term viability of graduate education at USU. Possible solutions: We are seeking ways to enhance the preparation of our graduates for nontraditional research-related careers with an emphasis on federal service opportunities. We also see an opportunity to increase the use of graduate students as teaching assistants in medical, allied health and graduate courses for military students, re-instituting a teaching role that was part of the original rationale for creation of a graduate program at USU. • Fitting an integrated MD/PhD program into the current USU medical and graduate curricula: There has been considerable interest in a combined MD/PhD program at USU, but structuring this within the revised medical curriculum remains challenging. Civilian schools can offer a more integrated program with fewer scheduling difficulties created by the need to enter military service during training. It is also challenging to find time to complete both the required medical courses and the graduate courses needed to learn necessary research skills. Potential solution: Problems related to the curriculum could be alleviated by extending the period of time available for MD/PhD students to complete their PhD training. • Student life issues: Civilian USU graduate students are neither employees of the Federal government nor of the Henry M. Jackson Foundation (in most cases), and they are not members of the military. This creates a number of problems rated to their unique status within NSAB and indeed any DoD environment. Potential solution: Though bothersome, these matters are not significant impediments to their educational programs. However, the dean’s office is committed to making improvements in policy and practice where feasible. In this regard, the leadership of the GEO is setting up quarterly forums to promote regular open exchanges with the graduate student body. Specific areas of focus include health care and tax status of USU graduate students Funding/Budget Estimate/Fiscal Impact: None Staffing Impact: Significant Board Action Requested: None, information only October 2014 TAB 27 Daniel K. Inouye Graduate School of Nursing Report Daniel K. Inouye Graduate School of Nursing Uniformed Services University of the Health Sciences Uniformed Services University of the Health Sciences Board of Regents Board Brief Submitted by: Marguerite Littleton-Kearney, PhD, RN, FAAN Date: September 8, 2014 Title & School: Interim Dean, Graduate School of Nursing Phone: 301-295-9004 Purpose: Information Action ______ Subject: Dean’s Report – Daniel K. Inouye Graduate School of Nursing (GSN) 1. On July 9th a delegation from the South Korea Military Nursing Academy toured USU and met with Dr. Longacre, Dean Hinshaw and the Associate Deans in the GSN. BG Kyung-Hye Choi, Superintendent, Armed Forces Nursing Academy, and her staff are interested in sending Korean Army nurses to the USU PhD in Nursing program. a. An MOU between USU and the Korea Armed Forces Nursing Academy has been drafted and is being circulated for signature. 2. Center of Excellence for Military Families Inter Agency Agreement signed by HRSA and USU. a. Initial support of $100,000 will identify service and policy gaps to direct education and research initiatives associated with the health of military families with a focus on maternal-child care. b. HRSA and the GSN will work together to strategically capitalize on these initiatives with the goal of providing family-centered access and care to our beneficiaries. c. Penny Pierce, PhD, RN, FAAN to be the Director. 3. Interprofessional course on identification and treatment of military sexual trauma in development by Dr. Ann W. Burgess, D.N.S., RNCS, FAAN, the GSN and SOM faculty. a. Pilot course will be offered in November in the GSN. b. The online course units will be integrated into the SOM modules. c. Identification and treatment of military sexual assault will be incorporated in to a Bushmaster exercise in October 2014. d. Students from the SOM and the GSN will participate in an interactive patient session at the Simulation Center. They will interview a simulated patient with a history of recent sexual assault, perform the exam and begin to process a rape kit. After the exam, the students will discuss, in small October 2014 Daniel K. Inouye Graduate School of Nursing Uniformed Services University of the Health Sciences groups, the approach they take to the patient and areas that need improvement. 4. Nurse Midwifery Program a. Service Nurse Corps Chiefs formally requested USU to explore feasibility of adding a DNP Nurse Midwifery program for students from Army, Navy and Air Force. b. A business case analysis is in progress. 5. Faculty News: a. Reporting: 1) CDR Darren Couture, NC, USN CRNA as Clinical Site Director, RNA program, WRNMMC 2) Maj Brian Kittleson, USAF, NC as Clinical Site Director, FNP program, Wilford Hall 3) Col Marla DeJong, USAF, NC as Senior AF Advisor, assigned to the PhD program b. Departing: 1) CDR Robert Hawkins, NC, USN, Program Director and Chair, Registered Nurse Anesthesia program, to Naval Medical Center, Portsmouth. 2) Col Susan Perry USAF, NC, Senior AF Advisor, retiring effective 1 November 2014 3) CAPT John Maye NC, USN, Acting Associate Dean for Faculty Affairs and RNA faculty, retiring effective 1 December 2014 October 2014 TAB 28 Postgraduate Dental College Report Uniformed Services University of the Health Sciences Board of Regents Board Brief Submitted by: Patrick D. Sculley, DDS, MA Date: 5 Sep 2014 Title & Department: Executive Dean, Postgraduate Dental Phone: 210-808-4491 College (PDC); Sr. VP for University Programs (SVS) Purpose: Information X Action Subject: PDC and USU Southern Office Update Significant Issues: 1. The Commandant of the METC, RADM William Roberts has chartered an Integrated Product Team (IPT) to study degree affiliation for METC students. A notional concept for affiliation with USUHS for award of baccalaureate degrees for four program tracks has been drafted and is now undergoing detailed development to flesh out the specifics of this endeavor. The IPT is hopeful to conclude its study in October. The SVP represents the University on the IPT. The need for a ULB (unified legislation and budgeting) is anticipated. 2. On August 12-14, Dr. Marguerite Littleton–Kearney and colleagues from the GSN presented a research methodologies seminar at Ft Bragg for the faculty and dental residents of the endodontics and comprehensive dentistry residency programs. The seminar received rave reviews from the participants. This was a fine example of interprofessional education. The students received great assistance in jump starting their individual research products and Dr. Littleton-Kearney and her colleagues gained great appreciation for the nature and complexity of dental research projects. It is hoped that this seminar can become an annual event and provided to other PDC educational sites. 3. The Southern Office supported the visit to San Antonio of Dr Kellermann on August 24-26 and facilitated the visit of President Rice to San Antonio stakeholders and the educational programs at Ft Hood Sep 21-24. 4. The PDC submits to the Board several candidates for faculty appointment. 5. The Memorandum of Agreement between the Army Medical Department and USUHS regarding graduate dental education programs has been signed. 6. The Military Training Network (MTN) has conducted a total of 54 staff assisted visits from 25 October 2014 March - 15 August 2014. Of all sites visited, 9 sites scored 100% with no documentation errors. The other 45 training sites earned an average score of 94%. Twenty five sites will be recognized with a coin and/or a MTN letter of appreciation for outstanding performance. Ten additional training sites will require a SAV or mentorship. MTN will attempt to visit these sites before the end of December 2014. Eleven new affiliation requests were received for Basic Life Support (BLS) and four for Advanced Cardiac Life Support (ACLS). MTN will begin receiving and processing annual reports from 15 September thru 30 October 2014. A total of 540 training site re-affiliations are projected for FY15. 7. Tri-Service Center for Oral Health Studies completed a protocol for studying the frequency of emergencies following multiple dental procedures. Study objective is to determine if patients receiving multiple procedures have a greater frequency of emergencies than would be expected from adding the probabilities of each individual procedure. A pilot study indicated the only individual procedure associated with a greater than 10 percent probability of a dental emergency within 90 days following treatment is the removal of a tooth completely impacted in bone with unusual surgical complications. Study results will be used to determine if adjustments should be made to the DoD Dental Readiness Classification System. 8. Dr. Woodson Scott Jones, Dean of the San Antonio Uniformed Services Health Education Consortium (SAUSHEC) provides the following update on the proposed SAUSHEC/USUHS affiliation: "The MOA and by laws are moving through command review." Current & Future Concerns: None Funding/Budget Estimate/Fiscal Impact: ULB if METC affiliation is to come to fruition. Staffing Impact: To be determined. Board Action Requested: For information only. October 2014 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES 4301 JONES BRIDGE ROAO BETHESDA, MARYLAND 20814-4712 www.usuhs.mll DEPARTMENT OF MILITARY ANO EMERGENCY MEDICINE TELEPHONE: 301-295-3720 OSN 295-3720 FACSIMILE: (301) 2951773 15 September 2014 SUBJECT: SELECTION MEMORANDUM I recommend that the University offer a position to Dr. Eric B. Schoomaker, MD, PhD, as Professor (non tenured) and Vice Chair Centers, Programs, and Research (non-tenured) in the Department of Military and Emergency Medicine (MEM). The position was advertised for 42 days on Higher Ed Jobs. The inclusive dates of the posting are 18 March to 28 April 2014. There were only 2 applications for the position, and the quality of the applicants was good. Of the two applicants, only one of them was deemed by a committee of MEM and university faculty to be qualified, and he was selected for an interview. The interview took place on 25 August 2014. Dr. Schoomaker is uniquely qualified, and he will bring a mix of management skill, academic accomplishment, teaching ability, and service to the Department and to the University. I also solicited input from al the senior faculty in the Department, and there was unanimous consent that Dr. Schoomaker is the best selection for the position of Professor (non-tenured) and Vice Chair Centers, Programs, and Research (non-tenured). I most strongly support Dr. Schoomaker's selection. The base salary to be offered is Jer year, with no recruitment bonus. It is planned that he will enter on duty as of 6 October 2014 (the first duty day of the pay period starting on 5 October 2014). The complete CV is attached to this message. Sincerely, f Franc::/~is G. O'Connor,-- COL, MC, USA Professor and Chair, Military and Emergency Medicine Board of Regents Abbreviated Curriculum Vitae Name: Eric B. Schoomaker, MD, PhD Department: Military & Emergency Medicine Candidate for: Professor and Vice Chair, Centers & Programs. Will this position be newly tenured? No Citizenship: USA Current Professional Address, Academic Rank and Title: Scholar-in-Residence & Distinguished Professor of Military & Emergency Medicine, Office of the President, Uniformed Services University of the Health Sciences, Room C-1049, 4301 Jones Bridge Road, Bethesda, MD 20814 Education: 1971-1975 University of Michigan Medical School, Ann Arbor, MI, Degree: MD (with honors); 1975-1979 Rackham School of Graduate Studies, University of Michigan, Ann Arbor, MI, Degree: PhD (Human Genetics) GME or Post Doctoral Training: 1976-1979 Residency in Internal Medicine and Fellowship in Hematology, Duke University Medical Center, Durham, NC Academic Appointments: 1979-1982 Assistant Professor of Medicine, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 1982-1988 Associate Professor of Medicine, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 2007-2014 Distinguished Professor of Military and Emergency Medicine, Department of Military & Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD Hospital Appointments: 1997-1999 Evans Army Community Hospital (Fort Carson MEDDAC) 1999-2000 Dunham Army Health Clinic (Carlisle Barracks, PA) 2002-2005 Eisenhower Army Medical Center, Fort Gordon (Augusta), GA Military Assignments: 2007-2011 42nd Army Surgeon General and Commanding General, U.S. Army Medical Command, Washington, DC and San Antonio, TX 3/2007-12/2007 Commanding General, Walter Reed Army Medical Center and North Atlantic Regional Medical Command, Washington, DC 2005-2007 Commanding General, U.S. Army Medical Research & Materiel Command & Fort Detrick, MD and Chief, Army Medical Corps, Fort Detrick, MD Licensure: Maryland, expires 9/30/2015 Specialty Board certification: American Board of Internal Medicine 1979 American Board of Hematology 1982 Professional societies: Fellow, American College of Physicians Association of Military Surgeons of the United States (President, 2009- 2010) National Professional committees, Editorial Boards: 2014-Present Member, National Center for Complementary and Alternative Medicine (NCCAM) National Advisory Council Honors and Awards: 2012 -Laureate Award from the Army Chapter of the American College Physicians 2012 -Dr. Nathan Davis Award for Outstanding Government Service from the American Medical Association 2011 -University Medal, Uniformed Services University of the Health Sciences 2011 -Presidential Commendation, American Academy of Pain Management 2009 Doctor of Science from Wake Forest University Publications: List total number full length articles in peer review journals: 37 Provide complete citations for all publications in the last years: 1. JK Gilman, M Wright, HC Lane, and EB Schoomaker (2014) A Model of Federal Interagency Cooperation: The National Interagency Confederation for Biological Research. Biosecurity and Bioterrorism: Biodefense Strategy, Practice and Science; 12 (3): 144-150. 2. C Buckenmaier III, C Crawford, C Lee, E Schoomaker (2014) Are Active Self-Care Complementary and Integrative Therapies Effective for Management of Chronic Pain? A Rapid Evidence Assessment of the Literature and Recommendations for the Field. Pain Medicine; 15(Suppl 1). 3. E Schoomaker, C Buckenmaier (2014) Call to Action: “If Not Now, When? If Not You, Who?” Pain Medicine;14(Suppl 1):S4-S6. 4. C Buckenmaier, E Schoomaker (2014) Patients’ use of active, self-care complimentary and integrative medicine in their management of chronic pain symptoms. Pain Medicine;14(Suppl 1):S7-S8. 5. C Lee, C Crawford, E Schoomaker, Active Self-Care Therapies for Pain (PACT) Working Group (2014) Movement therapies for the self-management of chronic pain symptoms. Pain Med; 15(Suppl 1):S40-53. 6. R Delgado, A York, C Lee, Active Self-Care Therapies for Pain (PACT) Working Group (2014) (C. Buckenmaier and E Schoomaker [co-editors] and E Schoomaker as member of PACT) Assessing the quality, efficacy and effectiveness of the current evidence base of active self-care complementary and integrative medicine therapies for the management of chronic pain: A rapid evidence assessment of the literature. Pain Med;15(Suppl 1):S9-S20. 7. C Lee, C Crawford, A Hickey, Active Self-Care Therapies for Pain (PACT) Working Group (2014) (C. Buckenmaier and E Schoomaker [co-editors] and E Schoomaker as member of PACT) Mind-body therapies for the self-management of chronic pain symptoms. Pain Med 2;15(Suppl 1):S21-39. 8. D Teyhen, MF Bergeron, P Deuster, N Baumgartner, AI Beutler, SJ de la Motte, BH Jones, P Lisman, DA Padua, TL Pendergrass, SW Pyne, E Schoomaker, TC Sell, F O'Connor (2014).Consortium for Health and Military Performance and American College of Sports Medicine Summit: Utility of Functional Movement Assessment in Identifying Musculoskeletal Injury Risk. Current Sports Medicine Reports 13(1): 52-63 External Peer-Reviewed Grant Awards: None Current Teaching Responsibilities: Teach Medical History Taking and Physical Examination in Fundamentals Module (SOM) ; Served as small group facilitator for Human Context in Health Care (SOM); served as small group instructor in Pathology (SOM); Faculty for Bushmaster Exercise (MFP 202; MEM/SOM) 2012 and 2014; Faculty for Gunpowder (MFP 201; MEM/SOM); invited lecturer/seminar discussant in GSN and MHAP program (SOM); curriculum development in Complementary & Integrative Health & Medicine session for Intersession x2 (SOM); curriculum development in Leadership Series for Military Medical Practice & Leadership (MMP&L/MEM/SOM) Service to Department, School and university over last 3 years. 2014-Present Member, LCME Task Force and Self-Study Subcommittee; Co-Lead for Self- Study of two standards 2014-Present Chair, USU-Duke-Emory-NRMC Surgical Critical Care Institute (SC2I) Oversight Committee Member, National Center for Complementary and Alternative Medicine (NCCAM) National Advisory Council 2014-Present Chair, USU Strategic Framework & Performance Assessment Task Force 2013-Present Member, Henry M. Jackson Foundation for the Advancement of Military Medicine’s Center for Public-Private Partnerships (CP3) The Veteran Metrics Initiative Strategic Advisory Committee 2013-Present Member, USU Enlisted to Medical Degree Preparatory Program (EMDP2) Advisory Committee 2013-Present Member, USU Consortium for Health And Military Performance (CHAMP) External Advisory Committee 2012-Present Member of Scientific Advisory Board for Army STARRS Program (Army Study to Assess Risk and Resilience in Service Members), Department of the Army USU President’s Report Charles L. Rice, MD • Honor Code • Board of Regents Candidate o Leo Rouse, DDS (Attachment 1) o Caswell Evans, DDS (Attachment 2) o Harold Slavkin, DDS, PhD (Attachment 3) • FTE Constraints • Military Manpower Study • National Heart, Lung, and Blood Institute Project • New Salary Schedules • Enlisted to Medical Degree Preparatory Program • USU Strategic Framework (Attachment 4) October 2014 Attachment 4 UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES STRATEGIC FRAMEWORK 2014 – 2018 October 2014 Overview This Strategic Framework is a roadmap guiding all Uniformed Services University of the Health Sciences elements – Schools, Centers, Institutes, and Administrative Functions – to jointly accomplish the University’s mission and achieve the USU President’s vision. The University’s Mission The mission of the Uniformed Services University of Health Sciences is to educate, train, and comprehensively prepare uniformed services health professionals, officers, scientists, and leaders to support the Military and Public Health Systems, the National Security and National Defense Strategies of the United States, and the readiness of our Uniformed Services. USU President’s Vision Statement By the end of CY 2018, the Uniformed Services University of the Health Sciences will be widely recognized as the pre-eminent national educational institution for the creation of career uniformed services leaders in the health sciences who are prepared to serve the nation. USU will be a central hub for uniformed services-related health education and training, research and scholarship, leadership education and training, and national security as it relates to global health. Each USU graduate will be a health & healthcare professional and leader prepared with an outstanding health education, inter-professional health training, leadership training, and a deep and abiding commitment to selfless service, the uniformed services ethos, and the security of the United States. Values Integrity. We foster a culture of academic, physical, and moral integrity in our students, faculty, and staff, and we are uncompromising in our adherence to the highest standards of intellectual and personal integrity. Innovation. Our faculty, students, and staff contribute to and creatively employ knowledge in areas crucial to health and national security. Caring. We foster an atmosphere of caring, mutual respect, courtesy, pride in work, and combined uniformed services and academic professional development. Communication. We interact and share information in a timely manner with openness, candor, and sensitivity. 1 Excellence in Scholarship. We are committed to rigorous standards of scholarship – including teaching, research, integration and application - and academic freedom as fundamental to the advancement of knowledge and a lifetime of learning. Selfless Service. We are committed to serve those who defend the nation and all Americans at home and abroad. We are sensitive to the unique role that our Soldiers, Sailors, Airmen, Marines, Coastguardsmen and Public Health Service professionals play in our national security. Collaboration and Teamwork. We value the contributions of each member of our community and work to achieve an environment characterized by cooperation, collegiality, tolerance, mutual respect, and an appreciation of diversity, as well as facilitate cooperation and collaboration in our science, educational methodologies, research, and leadership. The Five Mission Domains 1. Education and Training. USU educates and trains health professionals and scientists dedicated to career service and leadership in the Department of Defense and United States Public Health Service. We build, sustain, and modify a curriculum that is: a. Integrated, enhancing course work that facilitates a rigorous exchange in and among the three primary academic schools: the School of Medicine, the Graduate School of Nursing, and the Postgraduate Dental College; b. State-of-the-art, leveraging and developing advanced educational methodologies – including distance-learning, integrated teaching, simulations and simulators – blended with proven medical education systems; c. Competitive and stimulating, drawing the best and brightest to USU to prepare for a uniformed services health career; d. Uniformed service-focused, graduating officers who are excellent leaders and superb physicians, nurses, psychologists, dentists, scientists, administrators, and other health professionals. 2. Research and Scholarship: USU research and scholarship are central to the other four mission domains. USU research focuses on: a. Basic research, developing new knowledge; b. Translational research, applying basic sciences to practical applications of interest to the DoD and PHS; c. Clinical research, generating and applying new knowledge to populations and individuals; d. System and operations research, generating and applying new knowledge to health systems worldwide; e. Population health research, focusing on health outcomes across various populations; f. Policy research, the development, application and evaluation of knowledge around which effective policy can be based. 2 3. Leadership. Today’s USU graduates are tomorrow’s national uniformed medical, nursing, dental, health administration, and Public Health Service leadership. USU concentrates on leadership development and thought leadership: a. Leadership Development. USU graduates are tomorrow’s military health and Public Health Service leaders. USU is unique among health sciences educational institutions by integrating leadership responsibilities empowering students to develop necessary skills and abilities to become outstanding leaders at all levels of our nation’s uniformed health services; b. Thought Leadership. USU is widely accepted as a resource for critical information, thoughtful analysis, and valuable insight for current and future Military and Public Health leaders and practitioners in all health fields. 4. National Security and Global Health Engagement. The Military Health System and Public Health Service exist to ensure America’s security: a. USU provides education, training, and research in direct support of national strategies to protect the homeland and maintain our national interests abroad; b. USU is the hub of knowledge for military global health engagement activities around the world. 5. Service. USU faculty, staff, and students provide service to: a. The global community in support of the health of uniformed service members and U.S. interests; b. The American people; c. DoD and other federal agencies; d. The National Capital Area (NCA) community. Across all five mission domains, USU provides rigorous, standards-based, outcomes-oriented performance assessments. These assessments provide measures by which USU continuously evaluates its programs and, in turn, will be the basis upon which we will improve, sustain, and adapt our programs in the future. Domain Critical Tasks To realize the vision and accomplish the mission, USU needs to continue to fulfill essential tasks within each mission domain with empirically-based measures of performance. If these critical enabling tasks are achieved, then our strategic goals will be advanced and accomplished. These tasks include: 1. Education and Training a. Strengthen recruitment, development, and retention programs that make learning, employment, and collaboration at USU attractive and rewarding for outstanding and diverse students, faculty, and staff. b. Graduate outstanding physicians, nurses, psychologists, dentists, scientists, and administrators and professional uniformed services officers. 3 c. Maintain accreditations at the University level and coordinate and support accreditations of constituent schools and programs. d. Expand the use of cutting edge educational methodologies and teaching technologies. e. Generate resources (funding, physical plant, and personnel), strategically allocate these resources, and promote optimal efficiency in their use to enhance Education and Training. 2. Research and Scholarship a. Conduct innovative scholarship in basic, translational, clinical, systems and operations, population health, and policy research relevant to the MHS, the health of the nation, and national security. Our research and scholarship are conducted at USU and within the DoD academic health programs at the Walter Reed National Military Medical Center (WRNMMC), Fort Belvoir Community Hospital (FBCH), and other military health teaching sites in the National Capital Area (NCA) and research sites globally. Moreover, we collaborate with other appropriate national and international research organizations where such collaborations will enhance global health and/or national security. b. Generate resources (funding, physical plant, and personnel) and promote optimal efficiency in their use to enhance quality of faculty and student scholarship. c. Encourage and support participation of USU faculty, students, and staff in DOD, Uniformed Service-specific, international and national health-related meetings. 3. Leadership a. Maintain and expand leadership development education and training relevant to the MHS, PHS, national health and security. b. Maintain and expand USU’s role in thought leadership for the MHS, PHS, and health of the nation. 4. National Security and Global Health a. Expand USU’s role supporting national security. b. Develop USU’s capacity to support U.S. global health programs 5. Service a. Prepare and deploy health services engagement teams when requested by DOD and other U.S. agencies and organizations. b. Continue and expand service to the MHS, the Walter Reed National Military Medical Center and the NCA, the MHS’ network of clinics and hospitals worldwide, and above all to the individuals, units and leaders that comprise our uniformed services. Strategic Plans within USU Each school, center, and institute within USU will have an organizational strategy document that is consistent with the USU Strategic Framework. Each organization’s strategic plan should indicate how it contributes to the USU Strategic Framework; its roles and responsibilities; and how performance is monitored and outcomes improved. Each plan need not address all of the 4 USU mission domains; some are not appropriate for certain constituent organizations. While each plan will be different, all plans should contain, inter alia: • Mission • Vision • Mission Domains • Domain Critical Tasks. 5