Running head: MAIN EFFECTS AND AVERAGE EFFECTS 1 On the Relationship between ANOVA Main Effects and Average Treatment Effects Linda Graefe Friedrich Schiller University Jena Sonja Hahn University of Education Karlsruhe Axel Mayer Bielefeld University This is a preprint that has not undergone peer-review. April 30, 2021 Author Note Correspondence concerning this article should be addressed to Linda Graefe, Department of Psychological Methods, Institute of Psychology, Friedrich Schiller University, Am Steiger 3, Haus 1, D-07743 Jena, Germany, e-mail:
[email protected] This work was supported by a grant to the last author from the German Research Foundation (DFG; Grant No. MA 7702/1-1). MAIN EFFECTS AND AVERAGE EFFECTS 2 Abstract In unbalanced designs, there is a controversy about which ANOVA type of sums of squares should be used for testing main effects and whether main effects should be considered at all in the presence of interactions. Looking at this problem from a causal inference perspective, we show in which designs and under which conditions the ANOVA main effects correspond to average treatment effects as defined in the causal inference literature. We consider balanced, proportional and nonorthogonal designs, and models with and without interactions. In balanced designs, main effects obtained by type I, II, and III sums of squares all correspond to the average treatment effect. This is also true for proportional designs except for ANOVA type III which leads to bias if there are interactions. In nonorthogonal designs, ANOVA type I is always highly biased and ANOVA type II and III are biased if there are interactions.