Detection Technologies, Part 1
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Progress Report on a Pandemic
The international journal of science / 20 August 2020 other diseases were more likely to be admitted to intensive care, whereas children seemed to have milder disease4. Progress report But it quickly became apparent that SARS-CoV-2 is not just a respiratory virus. It also affects blood vessels, causing on a pandemic thrombosis5 and strokes6. Autopsies have found the virus in organs other than the lungs, including the kidneys, liver, heart and brain, In the first of a series of editorials, we as well as in the blood7. We now know that symptoms of look back at some of the key findings COVID-19 can include gastrointestinal, neurological, renal, from scientists’ race to demystify the new cardiovascular and other complications8. coronavirus. Something in the air n the space of eight months, the new coronavirus It soon became clear that SARS-CoV-2 could hop from SARS-CoV-2 and the disease it causes, COVID-19, have one person to another. This could happen through direct dominated the work of thousands of researchers in an contact or indirect transmission, such as through drop- unprecedented global effort. lets expelled during a cough, or even a simple exhalation. In a series of editorials, we look back at key scientific What wasn’t clear — and is still a matter of debate — is how Ifindings that have revealed important characteristics of big those droplets need to be, and how far they can travel. the virus and COVID-19, including emerging approaches to It’s an important question. Larger droplets will quickly treatment and prevention. We begin, this week, with how fall to the ground, but smaller, lighter ones — known as aer- the virus was identified; how it transmits between people; osols — can stay suspended in the air. -
US and International Responses to the Global Spread of Avian
Order Code RL33219 CRS Report for Congress Received through the CRS Web U.S. and International Responses to the Global Spread of Avian Flu: Issues for Congress Updated February 23, 2006 Tiaji Salaam-Blyther and Emma Chanlett-Avery Coordinators Foreign Affairs, Defense, and Trade Division Congressional Research Service ˜ The Library of Congress U.S. and International Responses to the Global Spread of Avian Flu: Issues for Congress Summary One strain of avian influenza currently identified in Asia, Europe, the Middle East, and Africa is known as Influenza A/H5N1. Although it is a bird flu, it has infected a relatively small number of people — killing around 50% of those infected. Some scientists are concerned that H5N1 may cause the next influenza pandemic. Flu pandemics have occurred cyclically, between every 30 and 50 years. Since 1997, when the first human contracted H5N1 in Hong Kong, the virus has resurfaced and spread to more than a dozen countries in Asia and eastern Europe — infecting more than 170 people and killing more than 90. In February 2006, the virus spread further to countries in western Europe. That month, officials confirmed that birds in Austria, Germany, Greece, and Italy were infected with the virus. Health experts are investigating suspected bird cases in France. The first human H5N1 fatalities outside of Asia occurred in 2006 when Turkey and Iraq announced their first human deaths related to H5N1 infection in January 2006 and February 2006, respectively. A global influenza pandemic could have a number of consequences. Global competition for existing vaccines and treatments could ensue. Some governments might restrict the export of vaccines or other supplies in order to treat their own population. -
Recent Articles from the China Journal of System Engineering Prepared
Recent Articles from the China Journal of System Engineering Prepared by the University of Washington Quantum System Engineering (QSE) Group.1 Bibliography [1] Mu A-Hua, Zhou Shao-Lei, and Yu Xiao-Li. Research on fast self-adaptive genetic algorithm and its simulation. Journal of System Simulation, 16(1):122 – 5, 2004. [2] Guan Ai-Jie, Yu Da-Tai, Wang Yun-Ji, An Yue-Sheng, and Lan Rong-Qin. Simulation of recon-sat reconing process and evaluation of reconing effect. Journal of System Simulation, 16(10):2261 – 3, 2004. [3] Hao Ai-Min, Pang Guo-Feng, and Ji Yu-Chun. Study and implementation for fidelity of air roaming system above the virtual mount qomolangma. Journal of System Simulation, 12(4):356 – 9, 2000. [4] Sui Ai-Na, Wu Wei, and Zhao Qin-Ping. The analysis of the theory and technology on virtual assembly and virtual prototype. Journal of System Simulation, 12(4):386 – 8, 2000. [5] Xu An, Fan Xiu-Min, Hong Xin, Cheng Jian, and Huang Wei-Dong. Research and development on interactive simulation system for astronauts walking in the outer space. Journal of System Simulation, 16(9):1953 – 6, Sept. 2004. [6] Zhang An and Zhang Yao-Zhong. Study on effectiveness top analysis of group air-to-ground aviation weapon system. Journal of System Simulation, 14(9):1225 – 8, Sept. 2002. [7] Zhang An, He Sheng-Qiang, and Lv Ming-Qiang. Modeling simulation of group air-to-ground attack-defense confrontation system. Journal of System Simulation, 16(6):1245 – 8, 2004. [8] Wu An-Bo, Wang Jian-Hua, Geng Ying-San, and Wang Xiao-Feng. -
CODATA Workshop on Big Data Programme Book
Sponsor I CODACODATA S UU Co-Sponsors Organizer Workshop on Big Data for International Scientific Programmes CONTENTS I. Sponsoring Organizations International Council for Science (ICSU) I. Sponsoring Organizations 2 The International Council for Science (ICSU) is a the international scientific community to II. Programme 7 non-governmental organization with a global strengthen international science for the benefit of membership of national scientific bodies society. (121members, representing 141 countries) and international scientific unions (31 members). ICSU: www.icsu.org III. Remarks and Abstracts 13 ICSU mobilizes the knowledge and resources of Committee on Data for Science and Technology (CODATA) IV. Short Biography of Speakers 28 I CODACODATA S UU V. Conference Venue Layout 41 CODATA, the ICSU Committee on Data for Science challenges and ‘hot topics’ at the frontiers and Technology, was established in 1966 to meet of data science (through CODATA Task a need for an international coordinating body to Groups and Working Groups and other improve the management and preservation of initiatives). VI. General Information 43 scientific data. CODATA has been at the forefront 3. Developing data strategies for international of data science and data policy issues since that science programmes and supporting ICSU date. activities such as Future Earth and Integrated About Beijing 43 Research on Disaster Risk (IRDR) to address CODATA supports ICSU’s mission of ‘strengthening data management needs. international science for the benefit of society’ by ‘promoting improved scientific and technical data Through events like the Workshop on Big Data for About the Workshop Venue 43 management and use’. CODATA achieves this International Scientific Programmes and mission through three strands of activity: SciDataCon 2014, CODATA collaborates with 1. -
Detection Technologies, Part 2
www.engineeringvillage.com Citation results: 500 Downloaded: 4/24/2020 1. RESPIRATORY NITRIC OXIDE METER MAULT JAMES R Assignee: HEALTHETECH INC Publication Number: WO126547 Publication date: 06/07/2001 Kind: CORRECTED TITLE PAGE OF AN EP-A DOCUMENT Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 2. RESPIRATORY NITRIC OXIDE METER MAULT JAMES R Assignee: HEALTHETECH INC Publication Number: WO126547 Publication date: 04/19/2001 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 3. RESPIRATORY THERAPY APPARATUS AND METHODS KHASAWNEH, Mohammad, Qassim, Mohammad; SAGOO, Jeevan; VARNEY, Mark, Sinclair Assignee: SMITHS MEDICAL INTERNATIONAL LIMITED Publication Number: WO2015036723 Publication date: 03/19/2015 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 4. RESPIRATORY THERAPY APPARATUS AND METHODS BENNETT, Paul James Leslie Assignee: SMITHS MEDICAL INTERNATIONAL LIMITED Publication Number: WO2014202923 Publication date: 12/24/2014 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 5. RESPIRATORY THERAPY APPARATUS AND METHODS Khasawneh, Mohammad Qassim Mohammad; Sagoo, Jeevan; Varney, Mark Sinclair Assignee: SMITHS MEDICAL INTERNATIONAL LIMITED Publication Number: US20160213868 Publication date: 07/28/2016 Kind: Patent Application Publication Database: US Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 6. RESPIRATORY THERAPY APPARATUS AND METHODS BENNETT, Paul James Leslie Assignee: Smiths Medical International Limited Publication Number: EP3010396 Publication date: 04/27/2016 Kind: Patent Application Publication Database: EP Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. -
1. Sars-Cov Nucleocapsid Protein Epitopes and Uses Thereof
www.engineeringvillage.com Citation results: 500 Downloaded: 4/24/2020 1. SARS-COV NUCLEOCAPSID PROTEIN EPITOPES AND USES THEREOF KELVIN, David; PERSAD, Desmond; CAMERON, Cheryl; BRAY, Kurtis, R.; LOFARO, Lori, R.; JOHNSON, Camille; SEKALY, Rafick-Pierre; YOUNES, Souheil-Antoine; CHONG, Pele Assignee: UNIVERSITY HEALTH NETWORK; BECKMAN COULTER, INC.; UNIVERSITE DE MONTREAL; NATIONAL HEALTH RESEARCH INSTITUTES Publication Number: WO2005103259 Publication date: 11/03/2005 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 2. SARS-CoV-specific B-cell epitope and applications thereof Wu, Han-Chung; Liu, I-Ju; Chiu, Chien-Yu Assignee: National Taiwan University Publication Number: US20060062804 Publication date: 03/23/2006 Kind: Utility Patent Application Database: US Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data Provider: Engineering Village 3. A RECOMBINANT SARS-COV VACCINE COMPRISING ATTENUATED VACCINIA VIRUS CARRIERS QIN, Chuan; WEI, Qiang; GAO, Hong; TU, Xinming; CHEN, Zhiwei; ZHANG, Linqi; HO, David, D. Assignee: INSTITUTE OF LABORATORY ANIMAL SCIENCE OF CHINESE ACADEMY OF MEDICAL SCIENCES; THE AARON DIAMOND AIDS RESEARCH CENTER; QIN, Chuan; WEI, Qiang; GAO, Hong; TU, Xinming; CHEN, Zhiwei; ZHANG, Linqi; HO, David, D. Publication Number: WO2006079290 Publication date: 08/03/2006 Kind: Patent Application Publication Database: WO Patents Compilation and indexing terms, 2020 LexisNexis Univentio B.V. Data -
University of Copenhagen, Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark and 6James D
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Copenhagen University Research Information System MetaPGN a pipeline for construction and graphical visualization of annotated pangenome networks Peng, Ye; Tang, Shanmei; Wang, Dan; Zhong, Huanzi; Jia, Huijue; Cai, Xianghang; Zhang, Zhaoxi; Xiao, Minfeng; Yang, Huanming; Wang, Jian; Kristiansen, Karsten; Xu, Xun; Li, Junhua Published in: GigaScience DOI: 10.1093/gigascience/giy121 Publication date: 2018 Document version Publisher's PDF, also known as Version of record Document license: CC BY Citation for published version (APA): Peng, Y., Tang, S., Wang, D., Zhong, H., Jia, H., Cai, X., ... Li, J. (2018). MetaPGN: a pipeline for construction and graphical visualization of annotated pangenome networks. GigaScience, 7(11), 1-11. [giy121]. https://doi.org/10.1093/gigascience/giy121 Download date: 09. apr.. 2020 GigaScience, 7, 2018, 1–11 doi: 10.1093/gigascience/giy121 Advance Access Publication Date: 2 October 2018 Research Downloaded from https://academic.oup.com/gigascience/article-abstract/7/11/giy121/5114262 by Faculty of Life Sciences Library user on 13 December 2018 RESEARCH MetaPGN: a pipeline for construction and graphical visualization of annotated pangenome networks † † † Ye Peng 1,2,3, , Shanmei Tang 2,3,4, ,DanWang 2,3,4, , Huanzi Zhong 2,3,4,5, Huijue Jia 2,3,4, Xianghang Cai2,3, Zhaoxi Zhang2,3, Minfeng Xiao 2,3, Huanming Yang2,6,JianWang2,6, Karsten Kristiansen2,3,5, Xun Xu 2,3 and Junhua Li 1,2,3,4,* 1School of Biology and Biological -
Mudskipper Genomes Provide Insights Into the Terrestrial Adaptation of Amphibious Fishes
Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes You, Xinxin; Bian, Chao; Zan, Qijie; Xu, Xun; Liu, Xin; Chen, Jieming; Wang, Jintu; Qiu, Ying; Li, Wujiao; Zhang, Xinhui; Sun, Ying; Chen, Shixi; Hong, Wanshu; Li, Yuxiang; Cheng, Shifeng; Fan, Guangyi; Shi, Chengcheng; Liang, Jie; Tom Tang, Y; Yang, Chengye; Ruan, Zhiqiang; Bai, Jie; Peng, Chao; Mu, Qian; Lu, Jun; Fan, Mingjun; Yang, Shuang; Huang, Zhiyong; Jiang, Xuanting; Fang, Xiaodong; Zhang, Guojie; Zhang, Yong; Polgar, Gianluca; Yu, Hui; Li, Jia; Liu, Zhongjian; Zhang, Guoqiang; Ravi, Vydianathan; Coon, Steven L; Wang, Jian; Yang, Huanming; Venkatesh, Byrappa; Wang, Jun; Shi, Qiong Published in: Nature Communications DOI: 10.1038/ncomms6594 Publication date: 2014 Document version Publisher's PDF, also known as Version of record Citation for published version (APA): You, X., Bian, C., Zan, Q., Xu, X., Liu, X., Chen, J., Wang, J., Qiu, Y., Li, W., Zhang, X., Sun, Y., Chen, S., Hong, W., Li, Y., Cheng, S., Fan, G., Shi, C., Liang, J., Tom Tang, Y., ... Shi, Q. (2014). Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes. Nature Communications, 5(5594). https://doi.org/10.1038/ncomms6594 Download date: 29. sep.. 2021 ARTICLE Received 14 Aug 2014 | Accepted 16 Oct 2014 | Published 2 Dec 2014 DOI: 10.1038/ncomms6594 OPEN Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes Xinxin You1,2,*, Chao Bian1,2,*, Qijie Zan3,*, Xun Xu2,*, Xin Liu2, Jieming Chen1,2, Jintu Wang2, Ying Qiu1,2, Wujiao Li1, Xinhui Zhang1,2, Ying Sun2, Shixi Chen4, Wanshu Hong4, Yuxiang Li2, Shifeng Cheng2, Guangyi Fan2, Chengcheng Shi2, Jie Liang2, Y. -
The Genetic Structure of SARS‐
Received: 2 September 2020 Revised: 16 October 2020 DOI: 10.1002/bies.202000240 PROBLEMS & PARADIGMS Prospects & Overviews The genetic structure of SARS-CoV-2 does not rule out a laboratory origin SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation Rossana Segreto1 Yuri Deigin2 1 Department of Microbiology, University of Innsbruck, Innsbruck, Austria Abstract 2 Youthereum Genetics Inc., Toronto, Ontario, Severe acute respiratory syndrome-coronavirus (SARS-CoV)-2′soriginisstillcontro- Canada versial. Genomic analyses show SARS-CoV-2 likely to be chimeric, most of its sequence Correspondence closest to bat CoV RaTG13, whereas its receptor binding domain (RBD) is almost iden- Rossana Segreto, Department of Microbiology, tical to that of a pangolin CoV. Chimeric viruses can arise via natural recombination or University of Innsbruck, Technikerstraße 25, 6020 Innsbruck, Austria. human intervention. The furin cleavage site in the spike protein of SARS-CoV-2 confers Email: [email protected] to the virus the ability to cross species and tissue barriers, but was previously unseen No external funding was received for this work. in other SARS-like CoVs. Might genetic manipulations have been performed in order to Rossana Segreto and Yuri Deigin contributed evaluate pangolins as possible intermediate hosts for bat-derived CoVs that were orig- equally to this study. inally unable to bind to human receptors? Both cleavage site and specific RBD could result from site-directed mutagenesis, a procedure that does not leave a trace. Consid- ering the devastating impact of SARS-CoV-2 and importance of preventing future pan- demics, researchers have a responsibility to carry out a thorough analysis of all possible SARS-CoV-2 origins. -
COVID-19 and Infectious Diseases
World Scientific Titles on COVID-19 and Infectious Diseases GET THIS SPECIAL EBOOK PACKAGE ON COVID-19 AND INFECTIOUS DISEASES FOR YOUR INSTITUTION’S USE, AVAILABLE UNTIL MARCH 2021! Original price US$2,384 / GBP 2,020 Packaged price US$1,668 / GBP 1,415 Prevention and Control Hydrogen-Oxygen of COVID-19 Inhalation for Treatment Editor-in-chief Wenhong Zhang for COVID-19 (Huashan Hospital of Fudan University, With Commentary China) from Zhong Nashan by Kecheng Xu “World Scientific is to be congratulated (Jinan University, China) for rapidly pulling together a book written and edited by the Chinese teams who first COVID-19 pneumonia is ravaging the experienced and managed the Covid 19 world. Faced with the lack of specialized outbreak. This book’s free access is so treatment, a novel form of hydrogen- commendable, thus inevitably and rightly oxygen inhalation therapy has been increasing access to all; an excellent successfully developed. Molecular repository of up to date knowledge on the hydrogen, a very safe "physiological gas", greatest health challenge of our generation.” has proven to be able to reduce lung damage caused by viruses including COVID-19, improve dyspnea, and promote disease J Richard Smith recovery due to its healing biological properties. Imperial College, London, UK This book details an innovative form of treatment from theory to Shanghai COVID-19 Medical Treatment Expert Team edits this practice, and comprehensively discusses the rationality of this new timely guide for effective prevention and control of COVID-19. treatment for COVID-19 pneumonia. It is ideal not only for doctors, Readers will obtain useful guidance on prevention and control but also for the general public, as it provides new knowledge and of COVID-19 in different places ranging from homes, outdoors, effective treatment and rehabilitation methods to combat this highly workplaces, etc. -
WHO-Convened Global Study of Origins of SARS-Cov-2: China Part
WHO-convened Global Study of Origins of SARS-CoV-2: China Part Joint WHO-China Study 14 January-10 February 2021 Joint Report 1 LIST OF ABBREVIATIONS AND ACRONYMS ARI acute respiratory illness cDNA complementary DNA China CDC Chinese Center for Disease Control and Prevention CNCB China National Center for Bioinformation CoV coronavirus Ct values cycle threshold values DDBJ DNA Database of Japan EMBL-EBI European Molecular Biology Laboratory and European Bioinformatics Institute FAO Food and Agriculture Organization of the United Nations GISAID Global Initiative on Sharing Avian Influenza Database GOARN Global Outbreak Alert and Response Network Hong Kong SAR Hong Kong Special Administrative Region Huanan market Huanan Seafood Wholesale Market IHR International Health Regulations (2005) ILI influenza-like illness INSD International Nucleotide Sequence Database MERS Middle East respiratory syndrome MRCA most recent common ancestor NAT nucleic acid testing NCBI National Center for Biotechnology Information NMDC National Microbiology Data Center NNDRS National Notifiable Disease Reporting System OIE World Organisation for Animal Health (Office international des Epizooties) PCR polymerase chain reaction PHEIC public health emergency of international concern RT-PCR real-time polymerase chain reaction SARI severe acute respiratory illness SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 SARSr-CoV-2 Severe acute respiratory syndrome coronavirus 2-related virus tMRCA time to most recent common ancestor WHO World Health Organization WIV Wuhan Institute of Virology 2 Acknowledgements WHO gratefully acknowledges the work of the joint team, including Chinese and international scientists and WHO experts who worked on the technical sections of this report, and those who worked on studies to prepare data and information for the joint mission. -
Evaluating the Association of Clinical Characteristics with Neutralizing Antibody Levels in Patients Who Have Recovered from Mild COVID-19 in Shanghai, China
Research JAMA Internal Medicine | Original Investigation Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China Fan Wu, PhD; Mei Liu, MS; Aojie Wang, MS; Lu Lu, PhD; Qimin Wang, MS; Chenjian Gu, MS; Jun Chen, MD; Yang Wu, MS; Shuai Xia, PhD; Yun Ling, MD; Yuling Zhang, MS; Jingna Xun, MS; Rong Zhang, PhD; Youhua Xie, PhD; Shibo Jiang, MD, PhD; Tongyu Zhu, MD; Hongzhou Lu, MD; Yumei Wen, MD; Jinghe Huang, PhD Editor's Note page 1362 IMPORTANCE The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute Supplemental content respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health. The association between clinical characteristics of the virus and neutralizing antibodies (NAbs) against this virus have not been well studied. OBJECTIVE To examine the association between clinical characteristics and levels of NAbs in patients who recovered from COVID-19. DESIGN, SETTING, AND PARTICIPANTS In this cohort study, a total of 175 patients with mild symptoms of COVID-19 who were hospitalized from January 24 to February 26, 2020, were followed up until March 16, 2020, at Shanghai Public Health Clinical Center, Shanghai, China. EXPOSURES SARS-CoV-2 infections were diagnosed and confirmed by reverse transcriptase–polymerase chain reaction testing of nasopharyngeal samples. MAIN OUTCOMES AND MEASURES The primary outcome was SARS-CoV-2–specific NAb titers. Secondary outcomes included spike-binding antibodies, cross-reactivity against SARS-associated CoV, kinetics of NAb development, and clinical information, including age, sex, disease duration, length of stay, lymphocyte counts, and blood C-reactive protein level.