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Rabbit Anti-SEC31A antibody

SL4453R

Product Name: SEC31A Chinese Name: TransporterSEC31A抗体 1810024J13Rik; ABP125; ABP130; AU042160; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; MGC93320; transport protein Sec31A; Alias: SEC31 homolog A (S. cerevisiae); SEC31 like 1; SEC31 like protein 1; SEC31 related protein A; SEC31L1; VAP1; Web1 like protein; Yeast Sec31p homolog. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep, ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800ICC=1:100-500IF=1:100- 500（Paraffin sections need antigen repair） Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 133kDa Cellular localization: cytoplasmic Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLHwww.sunlongbiotech.com conjugated synthetic peptide derived from human SEC31A:51-150/1220 Lsotype: IgG Purification: affinity purified by Protein A Storage Buffer: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed: PubMed The protein encoded by this is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for Product Detail: vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).

Subunit: COPII is composed of at least 5 : the SEC23/24 complex, the SEC13/31 complex and SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12.

Tissue Specificity: Cytoplasm. Cytoplasmic vesicle; COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Note: Associates with membranes in a GTP-dependent manner.

Post-translational modifications: Monoubiquitinated by the BCR(KLHL12) E3 ubiquitin ligase complex, leading to regulate the size of COPII coats.

DISEASE: A chromosomal aberration involving SEC31A is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;4)(p23;q21) with ALK.

Similarity: Belongswww.sunlongbiotech.com to the WD repeat SEC31 family. Contains 8 WD repeats.

SWISS: O94979

Gene ID: 22872

Database links:

Entrez Gene: 22872 Human Omim: 610257 Human

SwissProt: O94979 Human

Unigene: 370024 Human

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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