Furcate Cord Insertion of the Umbilical Cord: Pathological and Clinical Characteristics in 132 Cases and a Review of the Literature
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Porphyromonas Gingivalis Within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome
RESEARCH ARTICLE Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome Sizzle F. Vanterpool1,2, Jasper V. Been1,3,4, Michiel L. Houben5, Peter G. J. Nikkels6, Ronald R. De Krijger7, Luc J. I. Zimmermann1,8, Boris W. Kramer1,2,8, Ann Progulske-Fox9, Leticia Reyes9,10* 1 Department of Pediatrics, Maastricht University Medical Center, Maastricht, the Netherlands, 2 School for Mental Health and Neurosciences (MHeNS), Maastricht University, Maastricht, the Netherlands, 3 School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, the Netherlands, 4 Division of Neonatology, Erasmus University Medical Center–Sophia Children’s Hospital, Rotterdam, the Netherlands, 5 Department of Pediatrics, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, the Netherlands, 6 Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands, 7 Department of Pathology, Erasmus University Medical Center, Rotterdam, the Netherlands, 8 School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, the Netherlands, OPEN ACCESS 9 Department of Oral Biology, Center for Molecular Microbiology, University of Florida, Gainesville, Florida, Citation: Vanterpool SF, Been JV, Houben ML, United States of America, 10 Department of Pathobiological Sciences, University of Wisconsin-Madison, Nikkels PGJ, De Krijger RR, Zimmermann LJI, et al. Madison, Wisconsin, United States of America (2016) Porphyromonas gingivalis within Placental * [email protected] Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome. PLoS ONE 11(1): e0146157. doi:10.1371/journal. pone.0146157 Abstract Editor: Motohiro Komaki, Tokyo Medical and Dental University, JAPAN Intrauterine presence of Porphyromonas gingivalis (Pg), a common oral pathobiont, is impli- cated in preterm birth. -
Gestational Diabetes Insipidus, HELLP Syndrome and Eclampsia in a Twin Pregnancy: a Case Report
Journal of Perinatology (2010) 30, 144–145 r 2010 Nature Publishing Group All rights reserved. 0743-8346/10 $32 www.nature.com/jp PERINATAL/NEONATAL CASE PRESENTATION Gestational diabetes insipidus, HELLP syndrome and eclampsia in a twin pregnancy: a case report JL Woelk, RA Dombroski and PR Brezina Department of Obstetrics and Gynecology, East Carolina University, Greenville, NC, USA alanine aminotransferase, 65 U lÀ1; and lactate dehydrogenase, We report a case of eclampsia in a twin pregnancy complicated by HELLP 390 U lÀ1. A 24-h urine collection was begun to quantify proteinuria. syndrome and diabetes insipidus. This confluence of disease processes During the first night of hospitalization, the patient developed suggests that a modification of common magnesium sulfate treatment marked polyuria and polydipsia. Urine output increased to 1500 cc hÀ1 protocols may be appropriate in a certain subset of patients. by the early morning totaling 12 l for the entire night. Repeat Journal of Perinatology (2010) 30, 144–145; doi:10.1038/jp.2009.115 electrolytes were unchanged. The endocrinology service was then Keywords: diabetes insipidus ; eclampsia ; HELLP syndrome ; twin consulted for the management of presumptive DI. Therapy with the pregnancy ; magnesium sulfate administration of dDAVP (1-deamino-8-D-arginine vasopressin) orally twice daily was initiated. Serum osmolality was increased at 296 mOsm kgÀ1, and urine osmolality was decreased to 71 mOsm kgÀ1 Introduction with a specific gravity of 1.000. The 24-h urine results showed a total The association between diabetes insipidus (DI) and liver protein of 780 mg. The patient denied the previously reported dysfunction in a preeclamptic patient has been established in headaches, blurry vision and right upper quadrant pain, and her blood multiple case reports.1 This case is an important example that pressures remained 140 to 155 mmHg (systolic) and 80 to 95 mmHg illustrates how the pathophysiology of DI and the pharmacokinetics (diastolic), consistent with a diagnosis of mild preeclampsia. -
Incidence of Eclampsia with HELLP Syndrome and Associated Mortality in Latin America
International Journal of Gynecology and Obstetrics 129 (2015) 219–222 Contents lists available at ScienceDirect International Journal of Gynecology and Obstetrics journal homepage: www.elsevier.com/locate/ijgo CLINICAL ARTICLE Incidence of eclampsia with HELLP syndrome and associated mortality in Latin America Paulino Vigil-De Gracia a,⁎, José Rojas-Suarez b, Edwin Ramos c, Osvaldo Reyes d, Jorge Collantes e, Arelys Quintero f,ErasmoHuertasg, Andrés Calle h, Eduardo Turcios i,VicenteY.Chonj a Critical Care Unit, Department of Obstetrics and Gynecology, Complejo Hospitalario de la Caja de Seguro Social, Panama City, Panama b Critical Care Unit, Clínica de Maternidad Rafael Calvo, Cartagena, Colombia c Department of Gynecology and Obstetrics, Hospital Universitario Dr Luis Razetti, Barcelona, Venezuela d Unit of Research, Department of Gynecology and Obstetrics, Hospital Santo Tomás, Panama City, Panama e Department of Gynecology and Obstetrics, Hospital Regional de Cojamarca, Cajamarca, Peru f Department of Gynecology and Obstetrics, Hospital José Domingo de Obaldía, David, Panama g Unit of Perinatology, Department of Gynecology and Obstetrics, Instituto Nacional Materno Perinatal, Lima, Peru h Department of Gynecology and Obstetrics, Hospital Carlos Andrade Marín, Quito, Ecuador i Unit of Research, Department of Gynecology and Obstetrics, Hospital Primero de Mayo de Seguridad Social, San Salvador, El Salvador j Department of Gynecology and Obstetrics, Hospital Teodoro Maldonado Carbo, Guayaquil, Ecuador article info abstract Article history: Objective: To describe the maternal outcome among women with eclampsia with and without HELLP syndrome Received 7 July 2014 (hemolysis, elevated liver enzymes, and low platelet count). Methods: A cross-sectional study of women with Received in revised form 14 November 2014 eclampsia was undertaken in 14 maternity units in Latin America between January 1 and December 31, 2012. -
Low-Lying Placenta
LOW- LYING PLACENTA LOW-LYING PLACENTA WHAT IS PLACENTA PRAEVIA? The placenta develops along with the baby in the uterus (womb) during pregnancy. It connects the baby with the mother’s blood system and provides the baby with its source of oxygen and nourishment. The placenta is delivered after the baby and is also called the afterbirth. In some women the placenta attaches low in the uterus and may be near, or cover a part, or lie over the cervix (entrance to the womb). If it is shown in early ultrasound scans, it is called a low-lying placenta. In most cases, the placenta moves upwards as the uterus enlarges. For some women the placenta continues to lie in the lower part of the uterus in the last months of pregnancy. This condition is known as placenta praevia. If the placenta covers the cervix, this is known as major placenta praevia. Normal Placenta Placenta Praevia Major Placenta Praevia WHAT ARE THE RISKS TO MY BABY AND ME? When the placenta is in the lower part of the womb, there is a risk that you may bleed in the second half of pregnancy. Bleeding from placenta praevia can be heavy, and so put the life of the mother and baby at risk. However, deaths from placenta praevia are rare. You are more likely to need a caesarean section because the placenta is in the way of your baby being born. HOW IS PLACENTA PRAEVIA DIAGNOSED? A low-lying placenta may be suspected during the routine 20-week ultrasound scan. Most women who have a low-lying placenta at the routine 20-week scan will not go on to have a low-lying placenta later in the pregnancy – only 1 in 10 go on to have a placenta praevia. -
A Guide to Obstetrical Coding Production of This Document Is Made Possible by Financial Contributions from Health Canada and Provincial and Territorial Governments
ICD-10-CA | CCI A Guide to Obstetrical Coding Production of this document is made possible by financial contributions from Health Canada and provincial and territorial governments. The views expressed herein do not necessarily represent the views of Health Canada or any provincial or territorial government. Unless otherwise indicated, this product uses data provided by Canada’s provinces and territories. All rights reserved. The contents of this publication may be reproduced unaltered, in whole or in part and by any means, solely for non-commercial purposes, provided that the Canadian Institute for Health Information is properly and fully acknowledged as the copyright owner. Any reproduction or use of this publication or its contents for any commercial purpose requires the prior written authorization of the Canadian Institute for Health Information. Reproduction or use that suggests endorsement by, or affiliation with, the Canadian Institute for Health Information is prohibited. For permission or information, please contact CIHI: Canadian Institute for Health Information 495 Richmond Road, Suite 600 Ottawa, Ontario K2A 4H6 Phone: 613-241-7860 Fax: 613-241-8120 www.cihi.ca [email protected] © 2018 Canadian Institute for Health Information Cette publication est aussi disponible en français sous le titre Guide de codification des données en obstétrique. Table of contents About CIHI ................................................................................................................................. 6 Chapter 1: Introduction .............................................................................................................. -
Ophthalmic Associations in Pregnancy
CLINICAL Ophthalmic associations in pregnancy Queena Qin, Celia Chen, Sudha Cugati PREGNANCY RESULTS in various physiological variation in pregnancy.2 It normally changes in the female body, including in fades slowly after pregnancy and does the eyes. A typical pregnancy results in not need active intervention. Background A range of ocular pathology exists cardiovascular, pulmonary, metabolic, • Cornea – corneal thickness, curvature during pregnancy. Some pre-existing eye hormonal and immunological changes. and sensitivity may be altered during conditions, such as diabetic retinopathy, Hormonal changes occur, with a rise of pregnancy. Corneal thickness and can be exacerbated during pregnancy. oestrogen and progesterone levels to curvature can increase in pregnancy, Other conditions manifest for the first suppress the menstrual cycle.1 especially in the second and third time during pregnancy as a result of The eye, an end organ, undergoes trimesters, and return to normal in complications such as pre-eclampsia changes during pregnancy. Some of the postpartum period.3 Patients who and eclampsia. Early recognition and understanding of the management of these changes exacerbate pre-existing wear contact lenses may experience ophthalmic conditions is crucial. eye conditions, while other conditions intolerance to the use of contact lenses. manifest for the first time during Pregnant women should be advised Objective pregnancy. Early recognition and to delay obtaining a new prescription The aim of this article is to discuss the understanding of management of for glasses or undergoing a contact physiological and pathological changes in the eyes of pregnant women. ophthalmic conditions during pregnancy lens fitting until after delivery. Laser Pathological changes are sub-divided is crucial for the primary care physician. -
Gestational Diabetes Insipidus (GDI) Associated with Pre-Eclampsia
MOJ Women’s Health Case Report Open Access Gestational diabetes insipidus (GDI) associated with pre-eclampsia Abstract Volume 5 Issue 6 - 2017 Gestational diabetes insipidus (GDI) is a rare complication of pregnancy, usually developing in the third trimester and remitting spontaneously 4-6weeks post-partum. Afsoon Razavi, Muhammad Umair, Zehra It is mainly caused by excessive vasopressinase activity, an enzyme expressed by Tekin, Issac Sachmechi placental trophoblasts which metabolizes arginine vasopressin (AVP). The treatment Department of medicine, Icahn School of Medicine at Mount requires desmopressin. A 38year old G3P0A2 women with no significant medical Sinai/NYC Health+ Hospital/Queens, USA history was admitted to obstetrical service on 36th week of gestation due to significant malaise, anorexia, nausea, vomiting, polyuria, nocturia, and polydipsia, worsening Correspondence: Afsoon Razavi, MD, Department of in the 2weeks prior to presentation. Physical examination demonstrated decreased Medicine, Icahn School of Medicine at Mount Sinai/NYC skin turgor, hyperactive tendon reflexes and no pedal edema, and her blood pressure Health+Hospital/Queens, Diabetes center, 4th floor, Suit P-432, Pavilion building, Queens hospital center, 82-68 164th street, was 170/100mmHg, heart rate 67beats/min and weight 60kg (BMI 23.1kg/m2). Her Jamaica, New York, 11432, USA, Tel +8183843165, laboratory results a month prior to admission showed normal basic metabolic panel Email [email protected] and liver function tests. On admission she found to have urine osmolality112mOsmol/ kg (350-1000); serum osmolality 308mOsmol/kg (278-295); Urinalysis revealed Received: July 25, 2017 | Published: August 16, 2017 specific gravity less than 1005 with proteinuria. serum sodium 151mmol/L (135-145); potassium 4.1mmol/L (3.5-5.0); Cl 128mmol/L, urea 2.2 mmol/L (2.5-6.7), creatinine 1.4mg/dL, Bilirubin 1.3mg/dL, AST 1270 U/L, alkaline phosphatase, 717U/L, uric acid 10.1mg/dL and INR 1.1. -
Critical Care Issues in Pregnancy
CriticalCritical CareCare IssuesIssues inin PregnancyPregnancy Miren A. Schinco, MD, FCCS, FCCM Associate Professor of Surgery University of Florida College of Medicine, Jacksonville College of Medicine – Jacksonville Department of Surgery EpidemiologyEpidemiology •Approximately .1% of deliveries result in ICU admission • Generally, 75% - 80 % are during the post- partum period College of Medicine – Jacksonville Department of Surgery TopTop causescauses ofof mortalitymortality inin obstetricobstetric patientspatients admittedadmitted toto thethe ICUICU Etiology N (of 1354) Percentage Hypertension 20 21.5 Pulmonary 20 21.5 Cardiac 11 11.8 Hemorrhage 8 8.6 CNS 8 8.6 Sepsis/Infection 6 6.4 Malignancy 6 6.4 College of Medicine – Jacksonville Department of Surgery CriticalCritical illnessesillnesses inin pregnancypregnancy A. Conditions unique to pregnancy: account for 50-80% admissions to ICU(account for > 50% ICU admissions): • Preeclampsia / Eclampsia • HELLP syndrome • Acute fatty liver of pregnancy • Amniotic fluid embolism • Peri-partum cardiomyopathy • Puerperal sepsis • Thrombotic disease • Obstetric hemorrhage College of Medicine – Jacksonville Department of Surgery CriticalCritical illnessesillnesses inin pregnancypregnancy B. Pre-existing conditions that may worsen during pregnancy (account for 20-50% ICU admissions): • Cardiovascular: valvular disease, Eisenmenger’s syndrome, cyanotic congenital heart disease, coarctation of aorta, PPH • Renal: glomerulonephritis, chronic renal insufficiency • Hematologic: sickle cell disease, -
Three Typical Claims in Shoulder Dystocia Lawsuits
Three Typical Claims in Shoulder Dystocia Lawsuits Henry Lerner, MD Dr. Lerner practices obstetrics and gynecology at Newton-Wellesley Hospital in Massachusetts. t the end of a busy day, your office manager comes in The plaintiff’s lawyer and expert witnesses willclaim that it was holding a thick envelope. You don’t like the look on the physician’s duty to assess whether the baby was at increased her face. As she hands it to you, you see the return risk for shoulder dystocia at delivery. Plaintiffs will enumerate a Aaddress is a law firm. The envelope holds a summons indicating series of factors gleaned from their history and medical records that a malpractice lawsuit is being filed against you. The name which they will claim indicate that they were at increased risk of the patient involved seems only vaguely familiar. When for shoulder dystocia. Such factors include: you review the chart, you see that it was a delivery with a mild Prelabor risks (alleged): shoulder dystocia—four years ago. ■■ Suspected big baby As an obstetrician who has been in practice for more than 28 ■■ Gestational diabetes years, had numerous shoulder dystocia deliveries, and reviewed ■■ Large maternal weight gain close to 100 shoulder dystocia medical-legal cases, I have seen ■■ Large uteri fundal height measurement the above scenario played out frequently. In some cases, the ■■ Small pelvis delivery was catastrophic and the obstetrician was unsurprised ■■ Small maternal stature by the lawsuit. In most cases, however, the delivery was just ■■ Previous large baby one of hundreds or thousands the doctor has done over the ■■ Known male fetus years…and forgotten. -
Antepartum Haemorrhage
OBSTETRICS AND GYNAECOLOGY CLINICAL PRACTICE GUIDELINE Antepartum haemorrhage Scope (Staff): WNHS Obstetrics and Gynaecology Directorate staff Scope (Area): Obstetrics and Gynaecology Directorate clinical areas at KEMH, OPH and home visiting (e.g. Community Midwifery Program) This document should be read in conjunction with this Disclaimer Contents Initial management: MFAU APH QRG ................................................. 2 Subsequent management of APH: QRG ............................................. 5 Management of an APH ........................................................................ 7 Key points ............................................................................................................... 7 Background information .......................................................................................... 7 Causes of APH ....................................................................................................... 7 Defining the severity of an APH .............................................................................. 8 Initial assessment ................................................................................................... 8 Emergency management ........................................................................................ 9 Maternal well-being ................................................................................................. 9 History taking ....................................................................................................... -
Prioritization Changes
Oregon Health Plan Prioritized List changes Planned Out-of-hospital Birth The Health Evidence Review Commission approved the following changes to the Prioritized List of Health Services on August 13, 2020, based on the approved coverage guidance, “Planned Out-of- hospital Birth.” The changes will take effect on the Prioritized list of Health Services for the Oregon Health Plan on October 1, 2020. Changes for the Prioritized List of Health Services: GUIDELINE NOTE 153 PLANNED OUT-OF-HOSPITAL BIRTH Lines 1,2 Planned out-of-hospital birth is included on this line for pregnant women who are at low risk for adverse obstetric or birth outcomes. The high-risk conditions outlined below would either preclude coverage of planned out-of-hospital birth, necessitate a consultation, or require transfer of the mother or infant to a hospital setting. When a condition requiring transfer arises during labor, an attempt should be made to transfer the mother and/or her newborn; however, imminent fetal delivery may delay or preclude actual transfer prior to birth. Coverage of prenatal, intrapartum, and postpartum care is recommended with the performance of appropriate risk assessments (at initiation of care and throughout pregnancy and delivery) and the out- of-hospital birth attendant’s adherence to the consultation and transfer criteria as outlined below. When a high-risk condition develops that requires transfer or planned hospital birth, coverage is recommended when appropriate care is provided until the point the high-risk condition is identified. For women who have a high-risk condition requiring consultation, ongoing coverage of planned out-of- hospital birth care is recommended as long as the consulting provider’s recommendations are then appropriately managed by the out-of-hospital birth attendant in a planned out-of-hospital birth setting. -
Recode - Guidelines for Use the System Is Hierarchical I.E
ReCoDe - Guidelines for use The system is hierarchical i.e. categories at the head of the list take priority over those lower down. However multiple relevant conditions can be recorded. The primary condition is the highest on the list that is applicable to the case. Secondary condition is the next relevant condition down the list e.g. for codes B2, F3, and A7 - the primary code is A7, secondary code is B2 etc. ReCoDe - version 2.0 Group Condition further definition inclusion/exclusion A Fetus A1 Lethal congenital anomaly Lethal or severe. Any structural, genetic, or metabolic defect arising at conception or during embryogenesis incompatible with life or potentially treatable but causing death. A2 Infection Positive fetal microbiologic or serological culture. 2.1 Chronic – e.g. TORCH E.g. congenital or intrauterine pneumonia, cytomegalovirus, 2.2 Acute rubella, herpes. A3 Non-immune hydrops fetalis Presence of any two of the following signs: Ascites pericardial effusion pleural effusion subcutaneous oedema. A4 Iso-immunisation Blood group incompatibility rhesus or non rhesus (ABO). Death ascribable to blood group incompatibility. An indirect Coomb test greater than 1/16 and fetal hydrops (see A3). A5 Fetomaternal haemorrhage Haemorrhage into maternal circulation Kleihauer-Betke test > 0.4%1. A6 Twin-twin transfusion Presence of polyhydramnios (maximum vertical pocket of ≥ 8 cm) and oligohydramnios (maximum vertical pocket of ≤ 2 cm)2. A7 Fetal growth restriction SGA by customised percentile, intrauterine growth retardation. < 10th customised weight for gestational age centile3 OR IUGR reported on clinical or pathological grounds. A8 Other fetus Death due to other specific fetal conditions e.g.