Authors: Carol A Fulcher Anamika Kothari Ron Caspi Maneesh Yadav An online version of this diagram is available through BioCyc.org and may be used for analysis of omics datasets. Lines in the diagram correspond to reactions; nodes correspond to metabolites. Markus Krummenacker Ingrid Keseler Pathways are colored according to their cellular function, such as biosynthesis of cofactors. Mtbh37rvCyc: Mycobacterium tuberculosis H37Rv Cellular Overview Reactions not assigned to any pathway are in the far right of the cytoplasm. Suzanne Paley Peter D Karp In the membrane are transporters (with arrows) and other membrane proteins. a dimycocerosyl a mycobacterial phthiocerol sulfolipid connections between pathways are omitted for legibility.

Rv3237c Rv1490 Rv0068 LpqS Rv2729c Rv2042c Rv1006 Rv2901c LppX Rv1181 Rv1245c Rv0574c Rv3186 Rv3213c IniA PhoP Rv2998 Rv3779 CpsA Rv3173c KdpD Rv1075c Rv3691 Rv2690c Rv1639c Rv0968 SepF Rv3694c Rv2693c Rv1627c LpqN Rv0628c Rv1785c Rv0383c Rv1518 Rv0846c Rv0523c Rv2414c Rv3558 Rv0338c DppA Rv2994 Rv0849 Rv2715 Rv1648 Rv0897c ClpB Rv2942 Rv2963 Rv3271c GcpE Rv3885c RpsA Rv3055 Rv0463 Rv0398c Rv2551c Rv1753c Rv0613c Rv3474 Rv1254 Rv0460 Rv0364 Rv0999 Rv1671 Rv1988 Rv3000 Rv3657c Rv2144c TatA SupB CydD Rv0088 Rv3325 Rv1087A Rv3632 Rv3823c NusA Rv0246 Rv2732c Rv3401 Rv0774c Rv2185c SecA Rv2446c Rv0927c Rv3789 Rv1194c Rv1145 Rv1787 Rv1882c Rv3346c Rv0048c SigK Rv3723 Rv0064 Rv1172c Rv2644c Rv3738c Rv1546 Rv3018c Rv0826 Rv3394c Rv0093c Rv3035 Rv2676c Rv0842 Rv0490 UspC Rv3770c Rv1578c Rv0146 Rv3067 Rv0874c Rv0519c Rv1610 Rv0177 Rv1626 MbtD InfC Rv0566c Rv0207c EspR Rv3131

Rv1428c Rv1754c a dimycocerosyl a mycobacterial phthiocerol sulfolipid

Rv2198c Rv1050

Rv1091 Rv2600 Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Detoxification DnaJ Amine and Degradation/Utilization/ Fatty Acid and Lipid Biosynthesis Assimilation - Other Polyamine γ a ring-opened 7- β-D-glucose an oxidized L-alanyl- -D- a [protein]-L- adenosylcobalamin biosynthesis II (aerobic) Biosynthesis L-arabinitol 8-oxo-(d)GTP detoxification II cob(II)yrinate roseoflavin 6-phosphate glutamyl-L-lysyl- ditrans,octacis- proline (ω = 180) mycothiol flavin biosynthesis I (bacteria and plants) superpathway of adenosylcobalamin salvage from cobinamide I thiamine diphosphate adenosylcobalamin NAD salvage pathway I (PNC VI cycle) thiamine diphosphate Fermentation mixed acid fermentation reactive oxygen species degradation oxidized GTP and octane oxidation methylguanine in DNA ATP ATP coenzyme F 420 trans, trans-farnesyl superpathway of mycolate biosynthesis a,c-diamide 5’-phosphate D-alanyl-D-alanine undecaprenyldiphospho- oxidation biosynthesis I (E. coli) salvage from cobalamin biosynthesis II (Bacillus) dimycocerosyl triglycosyl spermidine dGTP detoxification glucose-6- Probable NADP- Rv2617c diphosphate biosynthesis p-HBAD biosynthesis Possible N-acetyl-(N- Rv1815 glu phenolphthiocerol biosynthesis probable Probable Rv0368c + biosynthesis I formamidopyrimidine- probable cob(I)alamin phosphate dependent alcohol acetylglucosaminyl) a tRNA NAD phosphoenolpyruvate bifunctional cob(II)inamide 2-[(2R,5Z)-2-carboxy- 2-(2-carboxy-4- dGTP GTP superoxide NADH adenosyltransferase: dehydrogenase: dehydrogenase γ iron- mycothiol cob(I)alamin acetyl-CoA DNA glycosylase muramoyl-L-alanyl- - GTP HMP-PP 4-methylthiazol-5(2H)- HMP-PP methylthiazol-5- cobO AdhC: adhC penicillin- regulated IPP chorismate dGTP GTP mycothiol-mediated (FAPY-DNA probable bifunctional fgd1 D-isoglutaminyl-N-(β- yl)ethyl phosphate a long-chain fatty acid binding peptidyl- ylidene]ethyl phosphate NAD phosphorylation and dephosphorylation SAM Periplasmic detoxification glycosylase): Rv0944 FAD synthetase/ D-asparatyl)-L-lysyl- Glutamyl-tRNA Cob(I)yrinic Thiamine-phosphate Thiamine-phosphate acetyl/propionyl- chorismate Probable Probable pyruvate riboflavin biosynthesis protein 1A/ prolyl Rv1178 synthetase: gltS pyrophosphorylase: Glutamine- pyrophosphorylase: superoxide dismutase Cob(I)yrinic Possible zinc- D-alanyl-D-alanineProbable Probable acid a,c-diamide coa carboxylase mycocerosic acid lyase: kinase PykA: pykA a reduced protein RibF: Putative F420- 1B: ponA1 cis-trans Rv1836c Rv2548 isopentenyl- thiE thiE 8-oxo-dGTP 8-oxo-GTP [Cu-Zn] SodC: sodC acid a,c-diamide containing alcohol asparagine mycothione adenosyltransferase: cob(II)alamin dependent + alpha chain: adenylyltransferase: Rv2949c monobromobimane n-octane Probable dependent isomerase diphosphate riboflavin thiamine rubredoxin adenosyltransferase: riboflavin kinase synthetase reductase: mtr Glu NAD(+) probable NADH NAD 8-oxo-dGTP 8-oxo-GTP dehydrogenase biosynthesis Rv1314c thiamine phosphate accD6 accA3 fadD28 putrescine dAdoMet formamidopyrimidine- glucose-6- A: ppiA an L-glutamyl-[tRNA ] delta- pyrophosphatase: phosphate 4-hydroxybenzoate oxaloacetate Superoxide dismutase Rv1314c (flavokinase) + FMN NAD dependent ditrans,octacis-AsnB: asnB synthetase: 8-oxo-dGTP 8-oxo-GTP DNA glycosylase: fpg phosphate isomerase: idi protein: ribA1 Cob(I)yrinic pyruvate [FE] SodA: sodA alkane adenylyltransferase probable undecaprenyldiphospho- nadE nudC [+ 4 isozymes] a long-chain fatty- phosphatase: phosphatase: Possible mutator adenosyl-cob(III) AdhB: adhB Probable cob(I)alamin acid a,c-diamide 2,6-diamino-4- triphosphate (FAD dehydrogenase bifunctional Rv0831c Probable thiamine- Probable thiamine- Probable malate mycothiol- hydroxylase: an apurinic site yrinate a,c-diamide N-acetyl-(N- DMAPP 2,5-diamino-6- adenosyltransferase: acyl adenylate ester mutT1 mutT1 protein: mutT3 hydroxy-5-(N-methyl) Fgd2: fgd2 Probable Rv1112 Probable glutamyl- monophosphate adenosyltransferase: monophosphate acid hydrogen peroxide bimane conjugate rubB alkB within DNA pyrophosphorylase) membrane- acetylglucosaminyl) mycothione (5-phospho-D- cobO Probable NAD(P) Inorganic malonyl-CoA spermidine dehydrogenase: mdh formamidopyrimidine L-arabinopyranose Rv2469c tRNA reductase: hemA kinase: thiL Rv1314c nicotinate adenine kinase: thiL phosphatase Probable mutator (FAD synthetase) 6-phospho associated muramoyl-L-alanyl-γ- peptidyl- ribosylamino) NMN transhydrogenase polyphosphate/ fatty-acid-AMP synthase: a reduced dinucleotide subunit: [NAD] dependent malate 8-oxo-dGDP 8-oxo-GDP (FAD diphosphorylase) penicillin- β prolyl pyrimidin- [corrinoid ligase: fadD28 speE protein: mutT2 8-oxo-GMP mycothiol S 1-octanol D-glucono- D-isoglutaminyl-N-( - probable cob(I)alamin thiamine (subunit alpha): pntAa ATP-NAD fatty acid methylparaben (flavin adenine coenzyme F 420 cis-trans (S)-4-amino-5-oxopentanoate adenosyltranferase]- Rv2135c oxidoreductase: mez catalase: Rv2633c -conjugate 1,5-lactone binding D-asparaginyl)-L-lysyl- 4(3H)-one thiamine diphosphate kinase: ppnK synthase: fas a reduced Rv0135c adenosyltransferase: diphosphate [+ 2 isozymes] 8-oxo-dGDP 8-oxo-GDP amidase: dinucleotide protein 1A/ D-alanyl-D-alanine isomerase cob(II)inamide (R)-lactate catalase: katG 8-oxo-dGMP H 2 O c-type cobO [+ 2 isozymes] a long-chain fatty acyl- spermidine synthetase): ribF 1B: ponA2 B: ppiB Probable nicotinate- superpathway of heme b biosynthesis [+ 2 isozymes] 4-hydroxybenzoate formate acetyl-CoA (S)-malate phosphatase: phosphatase: mca Probable glutamate- geranyl Probable [mycocerosic acid synthase] cytochrome Rv3159c from uroporphyrinogen-III Rv1700 Rv1700 probable diphosphate nucleotide rhamnosyltransferase: L-alanyl-γ-D- a [protein]-L- an oxidized 1-semialdehyde 2,1- bifunctional cob(II)alamin- H 2 O hydroxyl radical bimane N-acetyl- adenylyltransferase: + Rv2962c roseoflavin adenine D-ala proline (ω = 0) 2 aminomutase: hemL riboflavin [corrinoid a malonyl-[acp] possible: hycD O 2 GlcN-Ins L-cysteinyl glutamyl-L- O c-type nadD NADP mycocerosate acetaldehyde citrate synthase: gltA2 fumarase: fum 1-octanal LpqL ω,E,E-farnesyl adenosyltranferase] uroporphyrinogen-III hycP hycQ hycE Probable phosphate 8-oxo-dGMP 8-oxo-GMP dinucleotide lysyl-D-alanine cytochrome Rv1242 biosynthesis [corrinoid synthase: mas 4-O-(α-L- conjugate acetyltransferase: pta dehydrogenase: hsaG 5-aminolevulinate diphosphate protein: ribG adenosyltranferase]- acyl carrier protein activation rhamnopyranosyl) Probable citrate synthase: acetoacyl-[acp] synthase II CitA: citA probable aldehyde cob(I)inamide -hydroxybenzoate CO 2 H 2 fumarate EspJ idsA1 5-amino-6-(5- Probable uroporphyrinogen synthase: fas a mycocerosyl- dehydrogenase: NaMN nicotinamide methyl ester a 7,8-dihydro-8- Nα,Nε-diacetyl-lysyl- a (7Z)-3-oxo- Probable delta- phospho-D- decarboxylase: hemE [mycocerosic acid synthase] a phenolphthiocerol acetaldehyde cob(II)alamin- ethionamide pyridoxamine a uracil in DNA butan-1-ol Cob(I)yrinic acetyl phosphate Rv0458 methylmalonyl- aminolevulinic acid coenzyme A an apo acyl-carrier protein cob(I)alamin- probable fumarate ATP oxoguanine in DNA 5’-phosphate D-alanyl-D-alanine hexadec-7- Rv3335c (2E,6E)-farnesyl ribosylamino)uracil Nicotinic acid Pyrazinamidase/ [CblC-CblD Rv1993c acid a,c-diamide O-methyl-4-O-(α-L- citrate CoA mutase enoyl-[acp] dehydratase: hemB phosphopantetheinyl [corrinoid nicotinamidase: coproporphyrinogen III an acetoacetyl-[acp] reductase: frdA [+ 4 isozymes] complex] possible ethionamide S- Probable Probable NADP- diphosphate adenosyltransferase: phosphoribosyltransferase probable 5-amino-6-(5- adenosyltranferase] rhamnopyranosyl)- Probable NADP- frdB frdC frdD monooxygenase: Possible pyridoxamine Probable transferase: pptT PncB2: pncB2 pncA phenolphthiocerol Probable acetate Cob(I)yrinic formamidopyrimidine- uracil DNA dependent alcohol phosphoribosylamino) Rv1314c hydroxybenzoate 2’- dependent alcohol octanoate mymA 5’-phosphate oxidase bifunctional 3-oxoacyl- porphobilinogen D-ribulose dimycocerosyl kinase: ackA citrate hydro-lyase (cis- acid a,c-diamide DNA glycosylase: glycosylase, dehydrogenase Rv0594 uracil reductase: ribG holo-[acyl-carrier Cob(I)yrinic Probable 3- O-methyltransferase: pyruvate dehydrogenase (PNP/PMP oxidase) penicillin- [acyl-carrier 5-phosphate Nicotinic acid transferase: papA5 aconitate-forming): acn succinate Nucleoside and Nucleotide Degradation adenosyltransferase: Rv0944 UdgB: udgB AdhC: adhC Probable cob(I)alamin protein] synthase: acpS acid a,c-diamide Probable oxygen- oxoacyl-[acyl- Rv2959c fermentation AdhC: adhC ethionamide S- (pyridoxinephosphate binding protein] Rv2280 5-amino-6-(5- phosphoribosyltransferase acyl-CoA Rv1314c Rv3136 Probable porphobilinogen adenosyltransferase: adenosyltransferase: acetate protein 1A/ Probable phospho-D- 3’,5’-ADP a holo acyl-carrier protein independent carrier protein] to ethanol II monooxygenase: oxidase) (PNPOX) reductase: deaminase: hemC Rv1314c PncB1: pncB1 [+ 5 isozymes] cis-aconitate synthetase: probable Probable 1B: ponA1 Possible zinc- ribitylamino)uracil cobO coproporphyrinogen reductase: fabG2 ethA (pyridoxine 5’-phosphate fabG4 riboflavin a dimycocerosyl phenolphthiocerol p-HBAD-I superpathway of pyrimidine fadD32 formamidopyrimidine- protoporphyrinogen IX III oxidase: hemN pyruvate superpathway of purine deoxyribonucleosides degradation probable cob(I)alamin oxidase): Rv1155 uracil-DNA containing alcohol biosynthesis deoxyribonucleosides degradation DNA glycosylase: fpg Probable cob(I)alamin [+ 2 isozymes] ethanol adenosyltransferase: glycosylase: dehydrogenase preuroporphyrinogen protein: ribA2 adenosylcobinamide D-threo-isocitrate [+ 21 isozymes] ethionamide S- Rv2721c nicotinate Probable pyruvate cobO an apurinic site 7,8-dihydro- ung NAD dependent adenosyltransferase: dimycocerosyl hydro-lyase (cis- 2’-deoxycytidine a [cobalamin adenosylcobalamin- monooxygenase: [+ 2 isozymes] probable Probable Rv0082 protoporphyrinogen folate polyglutamylation a (3R)-3- O-methyl-4-O- decarboxylase: a [cyanocobalamin 8-oxoguanine AdhB: adhB Rv3870 cobO phenolphthiocerol aconitate-forming): acn octanoyl-CoA trafficking triphosphate [methylmalonyl- within DNA ethA2 an apyrimidinic bifunctional 3-oxoacyl- 1-deoxy-L- adenosylcobinamide protoporphyrinogen IX hydroxybutanoyl-[acp] (2-O-methyl-α-L- pdc reductase CblC] uracil oxidase: hemY 2’-deoxyguanosine PLP site in DNA membrane- [acyl-carrier glycero-tetrulose rhamnosyltransferase: rhamnopyranosyl) protein CblD] CoA mutase] 2-ethyl-4- ARP kinase: cobU adenosylcob(III) acetaldehyde butan-1-al Rv2962c D-threo-isocitrate sulfur dioxide associated protein] 4-phosphate alamin-[corrinoid a tetrahydrofolate 3-hydroxyacyl- -hydroxybenzoate Probable 2’-deoxyadenosine amidopyridine cytidine penicillin- reductase: adenosyltranferase] thioester α rhamnosyltransferase: See adenosyl-cobinamide 5,6-dimethylbenzimidazole an ( -L-rhamnopyranosyl) Probable purine binding fabG2 Rv1567c uroporphyrinogen-III dehydratase: htdX Rv2958c Probable NADP- isocitrate deaminase: thymidine Rv2073c 6,7-dimethyl-8- phosphate dimycocerosyl phenol-phthiocerol nucleoside protein 1A/ Cob(I)yrinic 10 cdd a (3R,7Z)-3- N -formyl-tetrahydrofolate biosynthesis dependent dehydrogenase: icd1 ribityllumazine Serine Probable [+ 3 isozymes] phosphorylase: Secondary Metabolite 1B: ponA2 hydroxy-hexadec- uroporphyrin-III C- nicotinate-nucleotide- acid a,c-diamide protoporphyrin IX α alcohol synthase: ribH adenosylcobinamide- hydroxymethyltransferase: folylpolyglutamate O-methyl-4-O-[ -L- Probable Probable deoD Degradation methyltransferase: hemD adenosyltransferase: (α-L- Probable isocitrate Possible cytidine/ 7-enoyl-[acp] dimethylbenzimidazole rhamnopyranosyl- dehydrogenase thymidine phosphate glyA2 synthase adenosine α ε phosphoribosyltransferase: Rv1314c a 10- a (2E)-but-2-enoyl-[acp] rhamnopyranosyl) α AdhC: adhC dehydrogenase deoxycytidylate N ,N -diacetyl- guanylyltransferase: a tetrahydrofolate Ferrochelatase: hemZ (1->3)-2-O-methyl- - phosphorylase: deaminase: D-ala Rv1186c S-adenosyl-L- protein: folC [NADP]: icd2 deaminase: Probable purine N-acetylglucosamine lysyl-D-alanine Rv0508 LipG 6,7-dimethyl-8-(1- cobT formyltetrahydrofolate dimycocerosyl deoA methionine:uroporphyrinogen- cobU Ferrochelatase Che1: che1 Serine L-rhamnopyranosyl]- nucleoside add probable cob(I)alamin phenol-phthiocerol [+ 5 isozymes] Rv3752c degradation I III C-methyltransferase: cysG D-ribityl)lumazine hydroxymethyltransferase hydroxybenzoate phosphorylase: adenosyltransferase: Probable crotonyl-[acp] rhamnosyl 2-O- 2-oxoglutarate adenosylcobinamide- α-ribazole 5’-phosphate 1 GlyA1: glyA1 thymine deoD Probable purine N-acetyl-D- cobO ferroheme b a tetrahydrofolate folylpolyglutamate reductase: fas methyltransferase: O-methyl-4-O-[α-L- ethanol inosine 5’- probable GDP molybdenum cofactor biosynthesis nucleoside glucosamine precorrin-1 Rv2959c 2’-deoxyuridine phosphate a (2R)-2-hydroxy a [glycerolipid]- an oxidized a (3R,5Z)-3- riboflavin synthase rhamnopyranosyl- cob(II)alamin- an apo-["base- acetyl-CoA α phosphorylase: 2’-deoxyinosine 6-phosphate a pimeloyl-[acp] ala pimeloyl-CoA ala oleate nitroaromatic hydroxy-tetradec- Rv1258c Rv1910c PqqE synthase: adenosylcobalamin 5-methyltetrahydrofolate- a 5,10- protein: folC (1->3)-2-O-methyl- - degradation ATP [CblC-CblD off/His-on" even numbered a butanoyl-[acp] deoD Probable N- compound 5-enoyl-[acp] uroporphyrin-III C- ribC ribH homocysteine methylenetetrahydrofolate L-rhamnopyranosyl]- Macromolecule complex] B12-enzyme] straight chain Possible acetyl-CoA Probable mycoside B acetylglucosamine- Possible Possible Probable mycothiol- methyltransferase: hemD cys methyltransferase: metH a 10- hydroxybenzoate Modification 2,3,4-saturated acetyltransferase Probable cobalamin 5’- 6-phosphate Cob(I)yrinic 8-amino-7- cyclopropane- formyltetrahydrofolate fucosyltransferase: IMP fatty acid acyl-CoA 8-amino-7- dependent 3-oxoacyl- ATP Probable 3-oxo- 2-deoxy-α-D- deacetylase: nagA acid a,c-diamide oxononanoate (acetoacetyl-CoA fatty-acyl- S-adenosyl-L- riboflavin phosphate mycoside B synthetase: oxononanoate nitroreductase: [acyl-carrier folylpolyglutamate hexanoyl-[acp] Rv2957 D-glucosamine thiolase): Rv1135A synthase TCA cycle protein Pupylation ribose 1-phosphate inosine-5’- adenosyltransferase: synthase: bioF2 phospholipid Rv2466c Rv1069c methionine:precorrin-1 C- Probable rhamnosyltransferase: fadD32 synthase: bioF2 protein] Rv2744c guanylyl molybdenum synthase synthase: fas and dePupylation monophosphate 6-phosphate Rv1314c synthase: ufaA1 Apa methyltransferase: cysG riboflavin CobS: cobS cysteine Rv2958c O-methyl-4-O-[α-L- a (R)-2-hydroxy reductase: protein: folC Probable acetyl-CoA molybdopterin- GTP cofactor biosynthesis [+ 2 isozymes] dehydrogenase: [+ 21 isozymes] kinase: ribF desulfurase fucopyranosyl-(1->3)- TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) even numbered Probable Probable Putative fabG4 synthase an [α-L-rhamnopyranosyl-(1->3)- a [prokaryotic guaB1 probable cob(I)alamin AMP acetyltransferase: Csd: csd α-L-rhamnopyranosyl- diphosphate straight chain 8-amino-7- 8-amino-7- Cyclopropane- NAD(P)H precorrin-2 MoO 2 - a 5,10- α fadA4 adenylyltransferase: 2-O-methyl- -L-rhamnopyranosyl] α ubiquitin-like protein] α adenosyltransferase: adenosylcobalamin a 3-oxohexanoyl-[acp] (1->3)-2-O-methyl- - uracil 2-deoxy- -D- 2,3,4-saturated oxononanoate oxononanoate fatty-acyl- nitroreductase FMN moeB2 molybdopterin methylenetetrahydrofolate dimycocerosyl phenol-phthiocerol C-terminal L-glutamine 2-deoxy-D-ribose [+ 2 isozymes] cobO 20 [2Fe-2S] iron-sulfur cluster biosynthesis 5’-phosphate Cysteine GTP 3’,8’- Dihydrofolate L-rhamnopyranosyl]- Pup ribose 1-phosphate α-D-glucosamine a [cobalamin a holo-["base- fatty acyl CoA synthase: bioF1 phospholipid acg: acg Probable Rv2415c Rv1823 cofactor (S)-malate 5-phosphate XMP a [cyanocobalamin synthase: bioF1 acetoacetyl-CoA precorrin-2 C - cyclase: reductase: dfrA a reduced 3-oxoacyl- Rv2576c desulfurase: a carboxy- hydroxybenzoate deamidase: 6-phosphate trafficking triphosphate off/His-on" synthase Probable α reductase CblC] 8-amino-7- 8-amino-7- methyltransferase: cobI adenosylcobalamin/ iscS moaA2 Serine Probable 3- [ -L-rhamnopyranosyl- malate dop protein CblD] B12-enzyme] acyl-carrier protein coenzyme A 1: cmaA1 nitroaromatic [acyl-carrier adenylated molybdopterin- a [prokaryotic oxononanoate oxononanoate hydroxymethyltransferase: oxoacyl-[acyl- (1->3)-2-O-methyl-α- O-methyl-4-O-[α- dehydrogenase: mdh compound protein] L-cysteine desulfurase alpha-ribazole an [L-cysteine [small subunit of ubiquitin-like protein] Probable bifunctional GTP 3’,8’- guanine L-rhamnopyranosyl] Probable a [glycerolipid]- reductase: precorrin-3A phosphatase: cobC molybdopterin glyA2 glycine carrier protein] L-fucopyranosyl- desulfurase]-S- dinucleotide [NAD] dependent malate C-terminal L-glutamate deoxyribose- dihydrosterculate FAD synthetase/ cyclase: a 7,8-dihydrofolate decarboxylase: a 5-methyltetrahydrofolate β-dihydromenaquinone- ω-sulfo-II-dihydromenaquinone- reductase: fabG2 dimycocerosyl (1->3)-α-L- 2-deoxy-D-ribose fabG2 Rv3886c Rv0402c sulfanyl-L-cysteine synthase] oxidoreductase: mez riboflavin biosynthesis moaA1 biosynthesis phenol-phthiocerol 5-phosphate phosphate Probable Serine lpdC gcvT gcvB 9 biosynthesis 9 biosynthesis rhamnopyranosyl- prokaryotic F6P a (5Z)-3-oxo- Rv2190c Precorrin-3B protein RibF: adenosylcobalamin protein A [+ 2 isozymes] fucosyltransferase: α aldolase: cysteine (8S)-3’,8-cyclo-7,8- hydroxymethyltransferase (1->3)-2-O-methyl- - ubiquitin- tetradec-5- synthase CobG: cobG riboflavin kinase MobA: mobA Rv2957 fumarase: fum deoC desulfurase dihydroguanosine 1 GlyA1: glyA1 β L-rhamnopyranosyl]- fumarate oxaloacetate like protein xanthosine enoyl-[acp] (flavokinase) + FMN molybdopterin guanylyl menaquinol-9 -dihydromenaquinone-9 a (3R)-3- Malate synthase Csd: csd 5’-triphosphate hydroxybenzoate 2’’’- ligase: pafA Probable adenylyltransferase synthase molybdenum hydroxyhexanoyl-[acp] G GlcB: glcB Rv1874 precorrin-3B II-dihydromenaquinone- an [α-L-fucopyranosyl-(1->3)-α- O-methyltransferase: deoxyribose- Rv1367c sulfurtransferase: dTMP cofactor citrate synthase: gltA2 (FAD cyclic pyranopterin ω Rv2956 N6-([prokaryotic phosphate D-glyceraldehyde 9 -hydroxylase: cyp128 L-rhamnopyranosyl-(1->3)-2-O acetaldehyde Probable purine γ 17 Cysteine pyrophosphorylase) moeB2 synthase: 3-hydroxyacyl- ubiquitin-like protein]- 3-phosphate N-acetyl-muramoyl-(L-alanyl- -D- 5-cis, 7-trans-3-oxo- + cholest-4- a (9Z)-3-oxo- Rv1089 monophosphate ω-hydroxy-β- α Probable citrate aldolase: NAD an aldehyde precorrin-3B C - desulfurase: thyA menaquinone-9 -methyl- -L-rhamnopyranosyl] succinate γ nucleoside glutamyl-L-lysyl-D-alanyl-D-alanine) a 2-oxo NADPH (FAD synthetase) synthase: moaC3 thioester O-methyl-4-O- -L-glutamyl)- deoC adenosylcobinamide- adenine ribotide L-ornithine tetradecadienoyl-CoA en-3-one octadec-9- methyltransferase: cobI iscS dihydromenaquinone-9 dimycocerosyl phenol-phthiocerol dehydrogenase: sdhA synthase II CitA: citA phosphorylase: carboxylate (FAD diphosphorylase) dehydratase: htdX [2-O-methyl-α-L- [protein]-L-lysine acetaldehyde probable bifunctional GDP phosphate probable NAD(P) enoyl-[acp] a thiocarboxylated [+ 2 isozymes] deoD Probable Possible zinc- cholest-4- (flavin adenine dehydrogenase: penicillin-binding Probable ornithine Rv0818 menaquinone- PAPS-dependent fucopyranosyl-(1->3)- [+ 3 isozymes] acetyl-CoA transhydrogenase: en-3-one 26- Probable Rv3590c an S-sulfanyl-[L- [small subunit of cyclic [+ 3 isozymes] α succinate aminotransferase containing alcohol precorrin-4 dinucleotide 9 β-reductase: sulfotransferase: pyridoxal 5’-phosphate biosynthesis II [ -L-fucopyranosyl- α-L-rhamnopyranosyl- citrate hsaG protein 1A/1B: ponA1 probable pntAa pntAb pntB 3-oxoacyl- molybdopterin N6- D-glyceraldehyde acyltransferase: dehydrogenase monooxygenase: cysteine desulfurase] synthetase): ribF pyranopterin (1->3)-α-L- acetaldehyde xanthine cobalamin 5’- (C-terminus menJ Rv2267c (1->3)-2-O-methyl-α- citrate hydro-lyase (cis- 3-phosphate fadA2 kshB cyp125 [acyl-carrier Rv1452c synthase] phosphate a (2E)-hex-2-enoyl-[acp] glyoxylate ([prokaryotic part): rocD2 NAD dependent rhamnopyranosyl- L-rhamnopyranosyl]- aconitate-forming): acn acetyl-CoA purine ribonucleosides degradation probable bifunctional phosphate protein] ω β ubiquitin-like Probable soluble AdhB: adhB precorrin-3 methylase: cobM -sulfo- - aldehydo-D-ribose D-glyceraldehyde (1->3)-2-O-methyl-α- Succinyl-CoA synthase: a (6S)-5- β-dihydromenaquinone-9 hydroxybenzoate γ acetaldehyde membrane-associated pyridine nucleotide reductase: dihydromenaquinone-9 gln ligase: sucD sucC protein]- - cobS Probable cholest-4- Rv0497 5-phosphate 3-phosphate L-rhamnopyranosyl] dehydrogenase: penicillin-binding Probable ornithine transhydrogenase: fabG4 Rv1431 formyltetrahydrofolate hexanoyl-[acp] L-glutamyl) α α beta-ketoacyl en-3-one 26- FAD molybdopterin dimycocerosyl protein 1A/1B: ponA2 Co -[ -(adenin-9-yl)]- aminotransferase Probable NADP- pyridoxal 5- O-methyl-4-O- -[protein]- hsaG sthA an S-sulfanyl-[cysteine synthase reductase: fas GMP Coβ-adenosylcobamide CoA thiolase monooxygenase: precorrin-5 phenol- [2-O-methyl-α-L- adenosine Cofactor, Prosthetic (N-terminus dependent alcohol phosphate L-lysine FadA3: fadA3 + cyp125 desulfurase]-[disordered- catalytic subunit phthiocerol 2’’’-O- urate Group, Electron N-acetyl-muramoyl-(L-alanyl-γ- 5’-phosphate part): rocD1 dehydrogenase Probable Rv3627c NAD phosphorylation synthase fucopyranosyl- succinyl-CoA cis-aconitate hydrolase: dop acetyl-CoA D-ala NADP NADH form scaffold 1: moaE1 methylenetetrahydrofolate methyltransferase: α Carrier Degradation D-glutamyl-L-lysyl-D-alanine) (3Z,5E)-dodeca- AdhC: adhC (25S)-3- 3-oxoacyl- superpathway of tetrahydrofolate biosynthesis and salvage and transhydrogenation (glutamine a hexanoyl-[acp] (1->3)- -L- isocitrate lyase: icl1 L-glutamate-5- a proteinogenic acetyl-CoA Rv0882 protein] complex dehydrogenase: folD Rv2956 Probable 3,5-dienoyl-CoA oxocholest- [acyl-carrier Rv2917 a 5,10- a 5,10- hydrolysing) rhamnopyranosyl- semialdehyde amino acid molybdopterin demethylmenaquinol- [+ 2 isozymes] a [prokaryotic heme degradation VII an alcohol 4-en-26-oate + methylenetetrahydrofolate methenyltetrahydrofolate (1->3)-2-O-methyl-α- 2-oxoglutarate:ferredoxin adenosine protein] Probable synthase 9 biosynthesis : snoP D-threo-isocitrate ubiquitin-like protein] NAD 3-oxo- oxidoreductase: deaminase: add reductase: cysteine a [2-O-methyl-α-L- L-rhamnopyranosyl]- hydro-lyase (cis- precorrin-6A octanoyl-[acp] C-terminal L-glutamate Inorganic methenyltetrahydrofolate PLP α hydroxybenzoate 4’’’- Rv2454c Rv2455c fabG2 Rv2530c desulfurase GTP molybdopterin all-trans- fucopyranosyl-(1->3)- -L- aconitate-forming): acn ferroheme b cyclohydrolase: folD 1,4-dihydroxy- synthase: fas O-methyltransferase: pyrimidine deoxyribonucleotides a (3R,9Z)-3- Csd: csd polyphosphate/ATP- synthase: nonaprenyl rhamnopyranosyl-(1->3)-2-O- xanthosine adenosine inosine guanosine Rv1996 Precorrin-6X NAD kinase: ppnK 2-naphthoate α Rv2955c dephosphorylation hydroxy-octadec- Rv2571c moaD2 moaE2 diphosphate [+ 3 isozymes] methyl- -L-rhamnopyranosyl] reductase CobK: cobK + a 10- 1,4-dihydroxy- 2-oxoglutarate D-threo-isocitrate 9-enoyl-[acp] Cysteine GTP NADP dimycocerosyl phenol-phthiocerol Probable purine Probable purine Probable purine Probable purine pyridoxal 5’-phosphate biosynthesis I formyltetrahydrofolate O-methyl-4-O-[2,4- Nucleoside triphosphate cyclohydrolase 1 2-naphthoate lipoprotein posttranslational nucleoside nucleoside nucleoside nucleoside heme heme desulfurase: a 3-oxooctanoyl-[acp] di-O-methyl-α-L- pyrophosphohydrolase: nonaprenyltransferase: Hydrogen phosphorylase: phosphorylase: oxygenase oxygenase precorrin-6B iscS type 2 homolog: molybdopterin [2-O-methyl-α-L- modification phosphorylase: phosphorylase: Rv3532 Probable NAD(P) menA fucopyranosyl-(1->3)- mazG Rv2230c D-erythrose Production deoD deoD deoD deoD (mycobilin a- (mycobilin b- UDP-N-acetyl-α-D-muramoyl-L- α-L-rhamnopyranosyl- 3-oxo-(5Z)- an organic a (7Z)-3- Rv3497c a [cysteine desulfurase]- transhydrogenase fucopyranosyl- α-L-rhamnopyranosyl- dCTP dCMP an oxidized c- xylitol Rv1855c 4-phosphate demethylmenaquinol-9 producing) producing) γ α (S)-lactate a [protein] Ser/Thr oxotetradec- S-sulfanyl-[disordered- Probable 3- (1->3)-α-L- (1->3)-2-O-methyl-α- isocitrate a [prolipoprotein]- alanyl- -D-glutamyl-meso-2,6- (1->3)-N-acetyl- -D- tetradecenoyl-CoA hydroperoxide Precorrin-6Y C(5,15) (subunit alpha): pntAa molybdopterin L-cysteine biosynthesis : mhuD : mhuD UDP-Galf type cytochrome form scaffold GTP oxoacyl-[acyl- rhamnopyranosyl- hydrogen L-cysteine diaminopimeloyl-D-alanyl-D-alanine glucosaminyl-diphospho- 7-enoyl-[acp] -methyltransferase adenylyltransferase: VI (from L-methionine) L-rhamnopyranosyl]- dehydrogenase: icd1 Probable Probable NADP- Alkyl [+ 2 isozymes] carrier protein] α production V probable bifunctional trans,octacis-decaprenol Possible L-lactate serine/threonine- (decarboxylating) protein] complex cyclohydrolase mog (1->3)-2-O-methyl- - hydroxybenzoate glu arabinogalactan acetyl-CoA dependent alcohol Probable prolipoprotein Probable deoxyuridine penicillin-binding dehydrogenase protein kinase hydroperoxide I: folE reductase: fabG2 L-rhamnopyranosyl] Probable isocitrate 3-oxoacyl- EsxD CobL: cobL 5’-triphosphate protein 1A/1B: ponA1 galactofuranosyl acyltransferase: transcriptional dehydrogenase reductase C Probable NADPH molybdopterin dimycocerosyl dehydrogenase diacylglyceryl (cytochrome) [acyl-carrier Rv2061c 4-phospho- met menaquinol-9 biosynthesis S-methyl-5’- S-methyl-5’-thioadenosine mycobilin a mycobilin b transferase 1: glfT1 fadA2 AdhC: adhC protein: ahpC Rv1522c cysteine 7,8- D-glyceraldehyde [+ 2 isozymes] formate transferase: lgt nucleotidohydrolase: dut α-D-ribose-1-phosphate β-D-galactofuranosyl-(1->5) LldD1: lldD1 regulatory adenine pyruvate D-erythronate phenol- [NADP]: icd2 thioadenosine degradation IV protein] precorrin-7 desulfurase dihydroneopterin 3-phosphate Probable S- O-methyl-4-O-[2,4- probable bifunctional -β-D-galactofuranosyl-(1->4) protein: pknK dinucleotide phthiocerol 4’’’-O- a [prolipoprotein]- degradation II reductase: Csd: csd 3’-triphosphate adenosylmethionine a (3R)-3- di-O-methyl-α-L- Nucleoside triphosphate membrane-associated -α-L-rhamnopyranosyl- Probable Possible zinc- Alkyl methyltransferase: UDP Possible L-lactate fabG4 molybdopterin demethylmenaquinol-9 hydroxyoctanoyl-[acp] S-1,2-diacyl-sn- pyrophosphohydrolase: S-methyl-5’- α [+ 10 isozymes] synthetase: metK Rv2955c fucopyranosyl- S-methyl-5’- penicillin-binding (1->3)-N-acetyl- -D- dehydrogenase beta-ketoacyl containing alcohol hydroperoxide Precorrin-6Y C(5,15) Probable α a reduced glyceryl-L-cysteine mazG thioadenosine Cysteine molybdotransferase: Probable ubiquinone/ (1->3)- -L- thioadenosine protein 1A/1B: ponA2 glucosaminyl-diphospho- (cytochrome) CoA thiolase a [protein] (L-serine/L- dehydrogenase reductase D Rv1325c Rv2826c -methyltransferase 1-deoxy-D- SAM 3-hydroxyacyl- hydrogenase 3 5’-methylthioadenosine Rv0834c desulfurase: moeA2 (3R)-3-hydroxy-2-oxo- menaquinone biosynthesis rhamnopyranosyl- dUTP dUMP Probable 5’- UDP-N-acetylmuramoyl-L- trans,octacis-decaprenol LldD2: lldD2 FadA3: fadA3 threonine) phosphate NAD dependent protein: ahpD Probable (decarboxylating) xylulose 5- thioester α D-ribose 5-phosphate nucleosidase: mtn γ iscS methyltransferase: menH a [2,4-di-O-methyl- -L- (1->3)-2-O-methyl-α- methylthioadenosine D-ala alanyl- -D-glutamyl-meso-2,6- AdhB: adhB CobL: cobL 7,8- 4 phosphooxybutanoate α (3Z)-dodec- 3-oxoacyl- molybdopterin phosphate dehydratase: htdX fucopyranosyl-(1->3)- -L- Glycolysis probable phosphorylase: pnp MTR diaminopimeloyl-D-alanine a reduced c- acetyl-CoA an alcohol dihydroneopterin L-rhamnopyranosyl]- possible: pyruvate 3-enoyl-CoA [acyl-carrier an S-sulfanyl-[cysteine synthase: menaquinol-9 rhamnopyranosyl-(1->3)-2-O- lipoprotein type cytochrome molybdotransferase: Possible hydroxybenzoate 3’’’- hycD D-xylopyranose protein] desulfurase]-S- 3’-phosphate dxs1 [+ 3 isozymes] α 5-hydroxy-CTP 5-hydroxy-CMP 5-MTR-1-P precorrin-8x moeA1 methyl- -L-rhamnopyranosyl] O-methyltransferase: hycP signal RpfB sulfanyl-[disordered- phosphoserine glycolysis I (from glucose 6-phosphate) reductase: Rv3417c Rv0591 dimycocerosyl phenol-phthiocerol Rv2954c hycQ hycE peptidase: form scaffold MoO 2 - aminotransferase: fabG2 SAH a (2E)-oct-2-enoyl-[acp] lspA Precorrin-8X molybdopterin serC a (3R,7Z)-3- protein] complex Probable D-glucopyranose methylmutase: cobH cofactor H 2 hydroxytetradec- 1-deoxy-D- 6-phosphate Probable 7,8- 4-phosphooxy- [2,4-di-O-methyl-α- xylulose 5- octanoyl-[acp] p-HBAD-II an (S-diacyl- 7-enoyl-[acp] cysteine dihydroneopterin L-threonine S-adenosylhomocysteine a lipoprotein Rv0681 chorismate phosphate reductase: fas L-fucopyranosyl- Amino Acid Degradation Rv3449 hydrogenobyrinate desulfurase mycothiol biosynthesis nucleosidase: mtn α sn-glyceryl) signal peptide Rv3499c synthase: (1->3)- -L- glucose-6- Csd: csd Probable -L-cysteinyl- para- dxs2 rhamnopyranosyl- phosphate dihydroneopterin [apolipoprotein] benzimidazole cyclic a thiocarboxylated a [ThiI sulfur- Probable cobyrinic D-glucopyranose S-ribosyl-L- an octanoyl-[acp] (1->3)-2-O-methyl-α- L-valine degradation I adenosylcobinamide- a (5Z)-3- aminobenzoate siroheme biosynthesis isomerase: pgi an acyl-CoA H 2 O a 3-oxoglutaryl- Cysteine aldolase: folB L-proline degradation an acyl-[acyl-carrier protein] a malonyl-[acp] ribotide pyranopterin [SAMP] C- carrier protein]- cys oxododec- acid A,C-diamide 6-phosphate homocysteine L-rhamnopyranosyl] L-isoleucine degradation I L-arginine degradation V GDP ATP [acp] methyl ester synthase: pabB 1-deoxy-D- 3-amino-1- phosphate phosphate terminal glycine stearate Rv1794 synthase CobB: cobB desulfurase: 2-carboxy-1,4- dimycocerosyl (arginine deiminase pathway) Probable acyl- L-cysteine 5-enoyl-[acp] BfrB 6-(hydroxymethyl) xylulose 5- hydroxyacetone 3-oxodecanoyl- Probable 3-oxoacyl- probable molybdopterin Cysteine iscS 4-amino-4- naphthoquinol biosynthesis inositol-1- phenol- F6P CoA thioesterase Probable Probable Rv1651c -7,8-dihydropterin phosphate 1-phosphate uroporphyrinogen-III [acp] β-D-mannosyl a peptide val [acyl-carrier protein] cobalamin 5’- stearate desulfurase: a [cysteine phosphate phthiocerol 3’’’-O- pro synthase II TesB1: tesB1 3-oxoacyl- 3-oxoacyl- hydrogenobyrinate a,c-diamide deoxychorismate phosphomycoketide an N-acyl-(S- ile reductase: fabG4 adenylyltransferase: iscS synthase: uroporphyrin-III C- synthase: fas methyltransferase: arg phosphate catalytic subunit [acyl-carrier [acyl-carrier desulfurase]-(S- 2-amino-4-hydroxy-6- chorismate methyltransferase: hemD biosynthesis diacyl-sn-glyceryl) Probable proline synthase: 2: moaE2 fadD23 sulfanyl) 2 -[disordered- ino1 Rv2954c Branched-chain Probable acyl- protein] protein] hydroxymethyldihydropteridinepyrophosphokinase: folK [+ 3 isozymes] fructose-1,6- 6-phosphofructokinase: -L-cysteinyl- Branched-chain dehydrogenase: Probable 3-oxoacyl- Probable Rv2574 isochorismate cobS reductase: reductase: LprP cobaltochelatase: cobN form scaffold L-homocysteine a medium- bisphosphatase: pfkA amino acid CoA thioesterase synthase: mbtI S-adenosyl-L- [lipoprotein] amino acid arginine Rv1188 [acyl-carrier protein] α α mycocerosic acid cysteine protein] complex (7,8-dihydropterin- chain acyl-CoA transaminase (S)-1-pyrroline- Co -[ - molybdopterin II: tesB2 fabG2 fabG4 Ins(3)P methionine:uroporphyrinogen- a 3-oxodecanoyl-[acp] gpm2 transaminase deiminase: reductase: fabG2 adenylyltransferase: desulfurase Rv3811 UDP-N-acetyl- mycoketide- 6-phosphofructokinase: (benzimidazolyl)]-Co synthase 6-yl)methyl pyridoxine PGL-tb IlvE: ilvE IlvE: ilvE 5-carboxylate GMP fadD28 Csd: csd 4-aminobenzoate Probable α-D-glucosamine Probable III C-methyltransferase: cysG pfkB arcA β-adenosylcobamide a carboxylate cob(II)yrinate a,c-diamide diphosphate 5’-phosphate CoA [+ 2 isozymes] acyl-carrier protein a 3-oxoacyl-[acp] catalytic subunit [+ 2 isozymes] isochorismate (S)-3-methyl-2-oxopentanoate (stearoyl)adenylate a [ThiI sulfur- a (3R)-3- cystathionine precorrin-1 synthase: 5’-phosphate 1: moaE1 Probable synthase: entC Probable 3- hydroxyglutaryl- Rv0405 beta- 3-methyl-2-oxobutanoate L-citrulline carrier protein]- 3-oxoacyl- Rv2076c D-inositol-3-phosphate phenolphthiocerol biosynthesis pks12 β-D-fructose 1,6- a [SAMP] C- ala Cob(I)yrinic acid a,c-diamide dihydropteroate synthase: cbs oxoacyl-[acyl- 5-oxo-L-proline metabolism molybdopterin S-sulfanyl- [acp] methyl ester [acyl-carrier a [cysteine desulfurase]- isochorismate Possible pyridoxamine uroporphyrin-III C- bisphosphate terminal glycine adenosyltransferase: synthase: folP2 glycosyltransferase: carrier protein] a mycoketide-CoA Probable L-cysteine [scaffold protein- 5’-phosphate oxidase methyltransferase: hemD protein] Rv0171 Rv1314c mshA reductase: fabG2 fructose- 3-methyl-2- L-glutamate-5- (2Fe-2S)] complex (PNP/PMP oxidase) acyl-CoA hydrolysis NADH repair a [protein] with a [protein] with reductase: dihydropteroate L-cystathionine chorismate oxobutanoate ornithine semialdehyde 2-succinyl-5- (pyridoxinephosphate DHAP bisphosphate an N-terminal fabG2 probable cob(I)alamin synthase: folP1 S-adenosyl-L- [+ 2 isozymes] an N-terminal 2-methylbutanoyl-CoA Rv2608 enolpyruvyl- aldolase dehydrogenase: carbamoyltransferase, Rv3921c adenosyltransferase: cobO 1-O-(2-acetamido- oxidase) (PNPOX) methionine:precorrin-1 C- L-glutamine L-glutamate a (3R,5Z)-3- a 2,3,4-saturated Fba: fba lpdC bkdC anabolic: argF Probable pyrroline- 6-hydroxy-3- (pyridoxine 5’-phosphate Cystathionine methyltransferase: cysG a (3R)-3- 2-deoxy-α-D- fatty acyl CoA chorismate lyase: Rv2949c triosephosphate NADH bkdA bkdB hydroxydodec- cob(II)yrinate a,c-diamide- cyclohexene- oxidase): Rv1155 gamma- hydroxydecanoyl-[acp] 5-carboxylate 7,8- glucopyranosyl)- isomerase: tpi 5-enoyl-[acp] Rv1969 [corrinoid adenosyltranferase] a [co-chaperone]- 1-carboxylate Probable a mycoketide dehydrogenase dihydropteroate 1D-myo-inositol synthase: metB precorrin-2 acyl-CoA RocA: rocA [scaffold protein- synthase: menD [+ 2 isozymes] 3-hydroxyacyl- isobutanoyl-CoA carbamoyl 3-phosphate thioesterase 4-hydroxybenzoate L-ornithine Rv2639c (2Fe-2S)] complex Probable thioester phosphate Rv3577 cys II: tesB2 a [protein] with (E)-2-methylcrotonoyl-CoA 6 37 a peptide with 2-succinyl-5-enolpyruvoyl- precorrin-2 dehydratase: htdX adenosylcobinamide- phenyl ribotide an (11Z)-3- folylpolyglutamate PLP an N-terminal 5- glu N -dimethylallyladenosine a sulfurated lauroyl-CoA H 2 O (2Z,6E)-farnesyl a 3-oxopimeloyl- 6-hydroxy-3-cyclohexene- dehydrogenase: cysG 4-hydroxybenzate GDP phosphate an N-terminal IPP oxo-icos-11- synthase oxo-L-proline probable in tRNA [sulfur carrier] arachidate ATP diphosphate [acp] methyl ester cob(I)yrinate a,c-diamide- 1-carboxylate [+ 3 isozymes] Probable adenylyltransferase: fadD22 D-glyceraldehyde (R)-NADHX steroid enoyl-CoA Xaa-L-proline enoyl-[acp] Rv0140 protein: folC a mycoketide carbamoyl- Probable acyl- [corrinoid adenosyltranferase] 3-phosphate Probable hydratase: echA9 probable Probable polyprenyl- a 5,10- acyl-CoA phosphate Probable CoA thioesterase Probable Probable a [chaperone-ATP]- 1-(2-acetamido- sirohydrochlorin NAD(P)H- pyrrolidone- phosphate cobalamin 5’- aminopeptidase arachidoyl diphosphate Rv1557 methenyltetrahydrofolate Probable a (2E)-dec-2-enoyl-[acp] thioesterase II methylacrylyl-CoA succinate II: tesB2 3-oxoacyl- 3-oxoacyl- Rv1056 7,8-dihydrofolate 2-deoxy-α-D- 4-hydroxybenzoyl-adenylate hydrate carboxylate synthase: phosphate PepC: pepC adenylyltransferase: synthase: Cob(I)yrinic acid a,c-diamide [co-chaperone]- bifunctional TesB1: tesB1 γ-L-glutamyl (2S,3S)-3-hydroxy-2- [acyl-carrier [acyl-carrier monoglutamate glyceraldehyde carA carB dehydrogenase thr adenosyltransferase: [scaffold protein- methenyltetrahydrofolate glucopyranosyl)- epimerase: peptidase: glutathione methylbutanoyl-CoA synthase: fadD26 grcC2 menaquinone NAD biosynthesis from 2- sirohydrochlorin a 2,3,4-saturated 3-phosphate 5-phosphate (hydrophobic Probable acyl- protein] protein] Rv1314c (2Fe-2S)] complex 1D-myo-inositol nnr pcp possible enoyl- cobS Probable cyclohydrolase: folD biosynthesis ferrochelatase: cysG decanoyl-[acp] 4-hydroxybenzyltransferase: dehydrogenase: (S)-NADHX membrane anchor CoA thioesterase reductase: reductase: NAD de novo biosynthesis amino-3-carboxymuconate fatty acid CoA hydratase: aminopeptidase mycocerosic acid Rv0124 protein: menD reductase: fas fadD22 a β-D-mannosyl gap carbamate subunit): sdhD II TesB1: tesB1 polyprenyl- fabG2 fabG4 riboflavin I (from aspartate) semialdehyde echA12 6 phenyl-Coβ- PepB: pepB adenylyltransferase: Rv1232c Probable cob(I)alamin a 10- N-acetyl-1-D-myo phosphomycoketide diphosphate LppA siroheme 2-methylsulfanyl-N - GMP adenosylcobamide a peptide with adenosyltransferase: cobO formyltetrahydrofolate (1R,6R)-6-hydroxy-2- -inositol-2-amino- 2-amino-3- an unsulfurated 37 a proteinogenic fadD28 laurate synthase: 4-hydroxybenzoyl-[4- [+ 8 isozymes] met 5’-deoxyadenosine dimethylallyladenosine an N-terminal (arachidoyl) [+ 2 isozymes] a 7,8-dihydrofolate succinylcyclohexa-2,4- 2-deoxy-α-D- carboxymuconate- [sulfur carrier] 5’-phosphate amino acid a (3R)-3- riboflavin kinase: ribF Probable 5’- a decanoyl-[acp] hydroxyphenylalkanoate synthase] L-phenylalanine grcC1 Probable asp 13-DPG 2-methylacetoacetyl-CoA in tRNA L-proline adenylate adenosyl-cob(III)yrinate a,c-diamide diene-1-carboxylate glucopyranoside 6-semialdehyde (S)-3-hydroxy- a mono-trans, poly- hydroxypimeloyl- 3-oxoacyl- a [chaperone- Dihydrofolate phosphoribosylglycinamide 5-oxo-L-proline degradation I (aerobic) L-threonine 3-O-phosphate an [2Fe-2S] deacetylase: mshB isobutanoyl-CoA [acp] methyl ester ADP]-[disordered- reductase: dfrA formyltransferase: purN Probable L-aspartate NADH cis-polyisoprenyl [acyl-carrier Rv3388 cluster protein o-succinylbenzoate 3-oxo- Possible acetyl-CoA Rv3094c FMN Probable cobyric acid CO 2 diphosphate protein] Rv1481 form scaffold synthase: menC oxidase NadB: nadB phosphopantothenate biosynthesis I dodecanoyl-[acp] (6R)-L-erythro-5,6,7,8- synthase CobQ1: cobQ1 quinolinate Probable Probable 5- acetyltransferase reductase: protein] complex GlcN-Ins 2-iminosuccinate synthase: fas tetrahydrobiopterin phosphoglycerate oxoprolinase: (acetoacetyl-CoA fabG2 Possible cobyric acid heme b biosynthesis kinase Pgk: pgk oplA thiolase): Rv1135A 2-succinylbenzoate quinolinic acid [+ 3 isozymes] a (3R,11Z)-3- synthase CobQ2: cobQ2 I (aerobic) 3-methyl-2-oxobutanoate 17-(4-hydroxyphenyl)heptadecanoyl- 19-(4-hydroxyphenyl)nonadecanoyl- a tetrahydrofolate L-cysteine:1-D- Probable quinolinate phosphoribosyltransferase: (S)-3-hydroxy-isobutanoate hydroxy-icos- glutathione- [4-hydroxyphenylalkanoate synthase] [4-hydroxyphenylalkanoate synthase] Rv0455c Rv3125c myo-inosityl 2- synthetase NadA: nadA nadC Probable acetyl-CoA 11-enoyl-[acp] Rv1496 (R)-1-amino-2-propanol O-2-phosphate adenosylcobyrate glutaredoxin Possible O- a 3-oxododecanoyl-[acp] 3-phospho-D-glycerate glu FMNH 2 an [Fe-S cluster a [disordered- uroporphyrinogen-III amino-2-deoxy-α- 3-methyl-2-oxobutanoate acetyltransferase: redox reactions succinylbenzoic 17-(4-hydroxyphenyl) 19-(4-hydroxyphenyl) Probable 3- biosynthesis form [Fe-S] cluster D-glucopyranoside hydroxymethyltransferase fadA4 Probable acid--CoA quinolinate NaMN heptadecanoyl-[PKS15/ nonadecanoyl-[PKS15/ hydroxyisobutyrate chaperone]-ATP scaffold protein] ligase: mshC PanB: panB Probable 3- glutathione uroporphyrinogen glutathione ligase: menE 1] thioesterase: tesA 1] thioesterase: tesA phosphoglycerate dehydrogenase: 4-methylphenyl a DNA containing an N-terminal- a (9Z)-3- adenosylcobinamide- oxoacyl-[acyl- 2,3-bisphosphoglycerate- propanoyl-CoA acetyl-CoA L-erythro-7,8- (6R)-4a-hydroxy- a (hydroxy) adenosylcobinamide- a [protein]- DHAP decarboxylase: hemE mmsB a cytosine in DNA PepR biosynthesis quinolinic acid Probable nicotinate- mutase: gpmA dihydrobiopterin 2’-palmitoyl/ ribotide S p methyl L-methionyl-L- oxohexadec- IPP Rv0440 LpqW phosphate synthase: cobD NAD salvage 2-dehydropantoate carrier protein] dependent tetrahydrobiopterin phthioceranyl- GDP L-cysteine 4-(2’-carboxyphenyl) deacetylmycothiol phosphate phosphotriester seryl-[protein] 9-enoyl-[acp] coproporphyrinogen III phosphoribosyltransferase: nucleotide reductase: fabG2 17-(4-hydroxyphenyl)heptadecanoate 19-(4-hydroxyphenyl)nonadecanoate [(hydroxy) stearoyl-2-O-sulfo- Probable glycerol- pathway III (to -4-oxobutyryl-CoA phosphoglycerate phosphoglycerate tRNA processing (S)-methylmalonate- methionine nadC adenylyltransferase: α,α-trehalose probable probable Probable DNA Probable 5,6-dimethylbenzimidazole nicotinamide riboside) mutase subunit: gpmA phthioceranic 3-phosphate Probable cys glu a reduced mutase: Rv3837c semialdehyde aminopeptidase: methylase LYTB-related mycothiol nadD Putative 2-dehydropantoate [+ 2 isozymes] acid synthase] 2’-palmitoyl/stearoyl-2-O- cobalamin 5’- bifunctional dehydrogenase 3-oxoacyl- adenosyl-cobinamide phosphate + glutaredoxin naphthoyl-CoA 17-(4-hydroxyphenyl) 19-(4-hydroxyphenyl) mapA biotin biosynthesis from synthase: 2-reductase: Rv2573 sulfo-α,α-trehalose (hydroxy) phosphate regulatory (modification [acyl-carrier protein nicotinate-nucleotide- Putative NADP synthase: menB NaMN heptadecanoate nonadecanoate a polycistronic [NAD(P)+]: gpdA2 Rv2452c 8-amino-7-oxononanoate I mshD nicotinate adenine a (3R)-3- phthioceranyltransferase: synthase: protein and methylase) protein] LytB2: lytB2 Rv0109 dimethylbenzimidazole adenylyltransferase: fadD29 adenylyltransferase: fadD29 2-phospho-D-glycerate tRNA precursor L-methionine degradation Rv1891 glutamate- acid phosphatase dinucleotide β-alanine hydroxydodecanoyl-[acp] Probable a 3’-(hydroxy) cobS methionine (methyltransferase) adenosylcobinamide- possible 1,4-dihydroxy-2- (R)-pantoate I (to L-homocysteine) L-serine papA1 DNA repair reductase: phosphoribosyltransferase: -cysteine subunit: Rv2135c Probable nicotinate- Putative aminopeptidase: : Rv3263 Probable glycerol- phosphate protoporphyrinogen IX glutaredoxin methylmalonate- degradation a holo-[(hydroxy) phthioceranyl-2’- enzyme: alkA fabG2 Probable cobT ligase 2: 8-amino-7-oxononanoate naphthoyl-CoA mycothiol nucleotide 4-methylphenyl-Co 3-phosphate protein: 3-hydroxyacyl- 17-(4-hydroxyphenyl)heptadecanoyl adenylate 19-(4-hydroxyphenyl)nonadecanoyl adenylate semialdehyde pterin-4-alpha- phthioceranic palmitoyl(stearoyl) mapB LYTB-related guanylyltransferase: cobU [+ 2 isozymes] Glutamine- GMP β-adenosylcobamide a DNA without a 5-methylcytosine Rv0433 Adenosylmethionine-8- + adenylyltransferase: nadD thioredoxin Probable Possible (S)-3-amino-2- carbinolamine -sulfo- a [protein]-S- dehydrogenase Probable Rv3198A dependent thioester Possible dehydrogenase: met acid synthase] -2-O S methyl an N-terminal [+ 2 isozymes] protein NAD pathway Pantoate--beta- enolase methylpropanoate α α 5’-phosphate p met in DNA [NAD(P)+]: gpdA1 RplL α amino-7-oxononanoate dehydratase: htdX ribonuclease ribonuclease mmsA dehydratase: , -trehalose methyl-L-cysteine L-seryl-[protein] a (3R,9Z)-3- LytB1: lytB1 Rv1216c -ribazole 5’-phosphate adenosylcobinamide-GDP protoporphyrinogen a [protein] NAD(+) alanine ligase: panC fatty-acid-AMP fatty-acid-AMP ser phosphotriester aminotransferase: bioA nicotinate adenine dinucleotide Eno: eno E Rne: rne E Rne: rne Probable S- Rv1159.1 hydroxyhexadec- Glutamate- oxidase: hemY synthetase: ligase: fadD29 ligase: fadD29 sn-glycerol (E)-4-hydroxy-3- Rv2203 probable NADH with reduced L- [+ 3 isozymes] adenosylmethionine 9-enoyl-[acp] -cysteine 7,8-diaminopelargonate nadE an oxidized Probable 3-phosphate methylbut-2-en- pyrophosphatase: cysteine residues 1,4-dihydroxy-2-naphthoate synthetase: metK [+ 2 isozymes] ligase: gshA Glutamine-dependent thioredoxin L-serine 1-yl diphosphate Probable cobalamin γ-L-glutamyl- protoporphyrin IX nudC (R)-pantothenate a 17-(4-hydroxyphenyl)heptadecanoyl- a 19-(4-hydroxyphenyl)-nonadecanoyl- phosphoenolpyruvate a tRNA precursor a tRNA precursor with hydrogencarbonate NAD(+) synthetase: nadE + a (2E)-dodec-2-enoyl-[acp] SAM dehydratase: [(phenol)carboxyphthiodiolenone synthase] [(phenol)carboxyphthiodiolenone synthase] with a 5’ extension a 5’ extension and Rv2129c 5’-phosphate L-cysteine Dethiobiotin geranylgeranyl NAD sdaA Rv0885 and a long 3’ trailer a short 3’ extension synthase CobS: cobS synthetase BioD: bioD Ferrochelatase: hemZ NMN diphosphate + pantothenate kinase: coaX 2-aminoprop- dihydro-4- + a PepB an (11Z)-3- Rv0742 biosynthesis NAD dodecanoyl-[acp] phenolpthiocerol C37-phenolphthiodiolenone Probable 2-enoate malonyl-CoA H a nucleoside GDP-α-D-mannose sn-glycerol Ferrochelatase Probable Probable pantothenate Ribonuclease coumaroyl-CoA a ribonucleic acid aminopeptidase oxooctadec- DMAPP reductase: fas synthesis type-I polyketide synthase: ppsE pyruvate RphA: rphA ATP cob(II)inamide triphosphate 3-phosphate dethiobiotin Che1: che1 thioredoxin kinase: coaA P protein substrate 11-enoyl-[acp] (2E,6E)-farnesyl synthase Pps: ppsA kinase Chalcone Possible GDP- adenosylcobalamin 5’-phosphate reductase: component: probable DNA- Probable probable glycerol- Probable Rv1421 diphosphate ppsB ppsC ppsD ppsE PykA: pykA Probable cob(I)alamin synthase mannose 4,6- Probable Rv1999c glutathione ferroheme b trxB2 a C37-phenolcarboxyphthiodiolenone- rnpA aminopeptidase 3-phosphate LYTB-related Probable biotin Probable (R)-4’-phosphopantothenate a dodecanoyl-[acp] SAH adenosyltransferase: cobO Pks10: pks10 directed RNA dehydratase: gca 3-oxoacyl- 1-(β-D ribofuranosyl) PepC: pepC synthetase BioB: bioB [(phenol)carboxyphthiodiolenone synthase] polymerase dehydrogenase: protein adenosylcobalamin/alpha- nicotinamide geranylgeranyl [acyl-carrier Rv1087 a C35-phenolcarboxyphthiodiolenone- a tRNA precursor a tRNA precursor with 2-iminopropanoate glpD2 LytB2: lytB2 pyrophosphate Cob(I)yrinic acid a,c-diamide Chalcone (omega GDP-D-mannose protein] ribazole phosphatase: cobC [(phenol)carboxyphthiodiolenone synthase] pyruvate with a 5’ extension Probable Probable synthetase: idsA2 C37- a short 3’ extension adenosyltransferase: chain): rpoZ dehydratase: reductase: biotin adenosylhomocysteinase: synthase aminopeptidase a reduced Probable 3- phenolcarboxyphthiodiolenone A- Rv1314c gmdA probable glycerol- fabG2 Probable Rv0361 GGPP Pks11: pks11 Rv0218 thioredoxin C35-phenolcarboxyphthiodiolenone sahH [+ 3 isozymes] PepB: pepB adenosylcobalamin oxoacyl-[acyl- [(phenol)carboxyphthiodiolenone GDP-4-dehydro- 3-phosphate LYTB-related A-[phthiodiolenone RphA: rphA triphosphate adenosylcobinamide phloretin a proteinogenic carrier protein] synthase] thioesterase: tesA a ribonucleic acid a peptide α-D-rhamnose dehydrogenase: [+ 2 isozymes] protein synthase] thioesterase: tesA a (3R,11Z)-3- laurate reductase: fabG2 L-homocysteine amino acid glpD1 LytB1: lytB1 LppM glycine cleavage pyruvate hydroxyoctadec- Pentose Phosphate Pathways (E)-4-hydroxy-3- [+ 3 isozymes] C37-phenolcarboxyphthiodiolenone DHAP 11-enoyl-[acp] Rv0746 acyl-CoA C35-phenolcarboxyphthiodiolenone methylbut-2-en- Rv3533c synthetase: an uncharged tRNA a [glycine- L-glutamate 1-yl diphosphate pentose phosphate pathway fadD32 cleavage complex6 degradation IX (via a 3-oxotetradecanoyl-[acp] H protein] N - 4-aminobutanoate) Rv1433 glycine [+ 21 isozymes] lipoyl-L-lysine an N-terminal- a peptidoglycan D-glucopyranose dehydrogenase: L-glutamine L-aspartate degradation I (2Z,4Z)-2-hydroxyhepta- (+)-7-epi- a (6Z)-3- Rv1880c tributyrin H 2 O a DNA segment Rv2468c superpathway of L-tryptophan biosynthesis Amino Acid Biosynthesis C36-phenolphthiodiolenone A 6-phosphate degradation I glu 2,4-dienedioate L-methionyl-L- dimer (S. aureus) jasmonoyl-CoA oxooctadec- superpathway of L- L-histidine biosynthesis L-arginine biosynthesis I (via L-ornithine) L-lysine biosynthesis I S-adenosyl-L-methionine cycle II lauroyl-CoA Probable 3- C34-phenolphthiodiolenone A gcvB ATP cob(II)alamin superpathway of L- superpathway of L- dihydrolipoamide alanyl-[protein] 6-enoyl-[acp] β 6 37 PE-PGRS family protein, 2-hydroxyhepta-2,4- probable isoleucine biosynthesis I tyrosine biosynthesis -alanine threonine biosynthesis oxoacyl-[acyl- methionine Probable Probable N -L-threonylcarbamoyladenosine dehydrogenase: Probable triacylglycerol lipase: lipY Probable phosphoenol D-erythrose biosynthesis III carrier protein] C36-phenolphthiodiolenone Probable glucose- asp Cob(I)yrinic acid a,c-diamide diene-1,7-dioate penicillin- acyl-CoA integrase/ phenolphthiodiolenone glutamate aminopeptidase: pyruvate 4-phosphate PRPP 6-phosphate 1- -modified tRNA biosynthesis lpdC gln isomerase: Rv0939 binding 3-oxoacyl- Rv0309 D-erythrose reductase: fabG2 A reductase: Rv2953 adenosyltransferase: tributyrin lipase: lipU mapA thioesterase II recombinase: oxaloacetate phosphoenol glu asp met A reductase: Rv2953 decarboxylase Probable aspartate [acyl-carrier Rv0457c oxaloacetate dehydrogenase: Rv1314c protein: dacB1 TesB1: tesB1 Rv1701 Rv1747 pyruvate 4-phosphate a [glycine- GMP GadB: gadB aminotransferase: aspC tributyrin lipase: lipN [+ 2 isozymes] zwf1 a [glycine-cleavage 2-hydroxyhepta-2,4- protein] 3-deoxy- Probable aspartate ATP asp Aspartokinase: Probable aspartate C36-phenolphthiodiolone A 6 synthase methionine C34-phenolphthiodiolone A thr cleavage complex6 [+ 2 isozymes] reductase: D-arabino- L-glutamate N- ask complex H protein] N - 4-aminobutanoate probable cob(I)alamin triacylglycerol lipase: lipD diene-1,7-dioate aminotransferase: phosphoribosyltransferase Probable aspartate aminotransferase: H protein] N - [glutamine- Possible aspartate aminopeptidase: a peptidoglycan Probable Probable 3-deoxy- a (3R)-3- aminomethyldihydrolipoyl- adenosyltransferase: cobO isomerase: Rv2993c fabG2 heptulosonate aspC HisG: hisG 1-decarboxylase acetyltranferase: aspC Probable 5- Probable glucose- Putative hydrolyzing]: aminotransferase: aspB tributyrin lipase: lipL mapB acyl-CoA integrase/ hydroxytetradecanoyl-[acp] dihydrolipoyl- D-ala with D,D cross- 7-phosphate D-arabino- argA L-aspartyl-4-phosphate methyltetrahydropteroyltriglutamate-- 6-phosphate 1- threonylcarbamoyl- L-lysine triphosphate precursor: panD L-proline biosynthesis III C34-phenolphthiodiolone L-lysine guaA oxaloacetate adenosylcobalamin butanoate 1,2-dibutyrin (4Z)-2-oxohept-4-enedioate an N-terminal L- link (S. aureus) thioesterase recombinase EsxE Rv0144 synthase: aroG Possible aspartate heptulosonate homocysteine methyltransferase: metE dehydrogenase: AMP synthase: Rv1301 met [+ 2 isozymes] Rv3230c 1-(5-phospho- β Possible aspartate ketoreductase: Rv2951c alanyl-[protein] II: tesB2 a (3R,6Z)-3- XerC: xerC β 7-phosphate -alanine N-acetyl-L- Probable S- 3-hydroxyacyl- zwf2 aminotransferase: -D-ribosyl)-ATP aminotransferase: (L-threonylcarbamoyl)adenylate [+ 7 isozymes] hydroxyoctadec- a DNA segment synthase: aroG glutamate adenosylmethionine thioester (+)-7-epi- aspB Aspartate- aspB 5-methyltetrahydrofolate- C36-phenolphthiotriol A glu 6-enoyl-[acp] 3-deoxy- glu synthetase: metK C34-phenolphthiotriol A 6-phospho L-asparagine jasmonate in reverse phosphoribosyl-ATP semialdehyde homocysteine dehydratase: htdX 6 L-glutamate D-arabino- D-glucono- N -L- Probable degradation I orientation asp pyrophosphatase: 3-deoxy- Probable dehydrogenase: asp methyltransferase: metH degradation I heptulosonate [+ 3 isozymes] threonylcarbamoyladenine aminomethyltransferase: Rv0977 Rv3815c hisE D-arabino- asd (phenol)phthiotriol 1,5-lactone Rv1797 7-phosphate acetylglutamate Probable C34-phenolphthiotriol gcvT heptulosonate methyltransferase: Rv2952 synthase: tsaE kinase ArgB: argB glutamate methyltransferase: Rv2952 Aspartokinase: 1-(5-phospho-β- 7-phosphate Aspartokinase: L-homocysteine SAM a (2E)-tetradec-2-enoyl-[acp] Probable 6- 6 asn (11Z,14Z,17Z)-3- an N-terminal- 4-(cytidine 5’- dihomo γ- 2-trans, 4-trans 3-dehydroquinate L-aspartate 4- 5-kinase an N -L- glu a very-long-chain di- CAIR H 2 O 3-phospho- ask D-ribosyl)-AMP ask phosphogluconolactonase: 37 a malonyl-[acp] oxoicosatrienoyl-CoA L-methionyl-L- diphospho)-2-C- linolenoyl-CoA thiosulfate -undecadienoyl- synthase N-acetylglutamyl- semialdehyde L-ornithine protein: proB C37-phenolphthiocerol A threonylcarbamoyladenine in tRNA L-asparaginase: unsaturated fattyl acyl-[acp] L-serine C35-phenolphthiocerol A devB L-alanine Probable NAD- valyl-[protein] methyl-D-erythritol CoA 3-dehydroquinate phosphate Probable Probable 3-oxoacyl- AroB: aroB myristoyl-[acp] degradation IV ansA dependent glutamate methionine Probable Rv2395 phosphoribosyl- synthase Probable ornithine meromycolic acid Probable 4- Rv2191 L-aspartyl- superpathway of branched chain amino acid biosynthesis Probable γ D-gluconate phosphoribosylaminoimidazole [acyl-carrier protein] acyl-CoA 3-phospho- Probable Rv3872 AMP 1,6 L-aspartyl- -L-glutamyl reductase: fas dehydrogenase: gdh 3-oxoacyl-(acyl aminopeptidase: diphosphocytidyl- AroB: aroB aminotransferase asp carboxylase catalytic subunit: purE reductase: fabG4 3-dehydroquinate 4-phosphate dihydrodipicolinate 4-phosphate 6-phosphate mapA thioesterase II L-serine- NADPH cyclohydrolase: Probable (N-terminus 5-phosphate 2-oxoglutarate carrier protein) 2-C-methyl- synthase: dapA ala TesB1: tesB1 dependent dependent hisI N-acetyl- part): rocD1 synthase II: kasB D-erythritol 3-dehydroquinate pyruvate Probable a myristoyl-[acp] Probable 6-phosphogluconate Probable Probable 3-oxoacyl- S-sulfo-L- 2,4-dienoyl- Aspartate- thr gamma- (2S,4S)-4- methionine 3-dehydroquinate Aspartate- gamma- phosphoribosylaminoimidazole kinase: ispE 1-(5-phospho-β-D-ribosyl)- hydroxy-2,3,4,5- dehydrogenase,decarboxylating Secreted L-alanine [acyl-carrier protein] cysteine CoA Rv3144c dehydratase: aroD semialdehyde glutamyl- semialdehyde Probable cyclopropane phosphatidylinositol mannoside biosynthesis [+ 2 isozymes] aminopeptidase: 2-phospho-4-(cytidine Probable CrgA Probable ornithine glutamyl Gnd2: gnd2 Respiration dehydrogenase: ald a very-long-chain carboxylase ATPase subunit: purK reductase: fabG2 synthase: reductase: 5-[(5-phosphoribosylamino) 3-dehydroquinate Probable phoshate tetrahydrodipicolinate mapB acyl-CoA Rv0589 dehydrogenase: dehydrogenase: phosphate adenosylhomocysteinase: fatty acid (CFA) acyl-carrier protein di-unsaturated 3- 5’-diphospho)-2-C- methylideneamino]imidazole- dehydratase: aroD acetolactate Probable aminotransferase Probable 3- (3R,11Z,14Z,17Z)-3- cysK2 fadH asd reductase asd sahH biosynthesis 6-phosphogluconate pyruvate AIR an N-terminal methyl-D-erythritol thioesterase 3-dehydroshikimate 4-hydroxy- (C-terminus reductase oxoacyl-[acyl- oxo-fatty-acyl-[acp] met 4-carboxamide synthase: ilvG L-serine ArgC: argC 2-oxoisovalerate decarboxylation to isobutanoyl-CoA hydroxyicosatrienoyl-CoA L-valyl-[protein] II: tesB2 protein: proA carrier protein] a 1-phosphatidyl-1D-myo-inositol dehydrogenase: gnd1 (3E)-undec- dehydratase: tetrahydrodipicolinate part): rocD2 a [phospholipid] S-sulfo-L-cysteine L-aspartate 4- 3-dehydroshikimate [+ 3 isozymes] L-aspartate 4- SAH di-homo-γ- 3-enoyl-CoA sdaA reductase: dapB reductase: fabG2 olefinic fatty acid Rv3895c Probable N-acetyl-L- D-ribulose Fatty Acid and Lipid Degradation Rv2626c Probable semialdehyde semialdehyde an [apo BCAA linolenate cyclopropane- phosphatidylinositol 5-phosphate Activation/Inactivation/ shikimate 5- phosphoribosylformimino- glutamate 5- [+ 3 isozymes] Rv3496c (S)-2-acetolactate (S)-2,3,4,5- alpha- dehydrogenase 6 Interconversion 5-aminoimidazole Probable Probable semialdehyde fatty-acyl- dehydrogenase: Probable tetrahydrodipicolinate Probable mannosyltransferase: E2 protein] N carboxamide ribotide shikimate 5- threonine phospholipid 3-methyl-2- superpathway of cholesterol degradation II (cholesterol dehydrogenase) aroE homoserine homoserine a 3-oxohexadecanoyl-[acp] pimA -lipoyl-L-lysine isomerase HisA: hisA dehydrogenase: Probable dehydratase Probable synthase: Probable Ribose-5- oxobutanoate ethionamide activation cholesterol degradation to (5Z,8Z,11Z,14Z,17Z)-3- 1-myristoyl- an N-terminal- cholest-4- 2-trans, 4-cis- dehydrogenase Tetrahydrodipicolinate dehydrogenase L-glutamate-5- L-proline a very-long-chain mono- an unsulfurated aroE KETOL-acid IlvA: ilvA acetylornithine mmaA2 ribulose- phosphate dehydrogenase: androstenedione I (cholesterol oxidase) a malonyl-[acp] oxodocosapentaenoyl-CoA a palmitoleoyl-[acp] sn-glycerol L-methionyl- 3’-dephospho- cys en-3-one undecadienoyl- NusG ThrA: thrA N-succinyltransferase ThrA: thrA semialdehyde α unsaturated acyl-[acp] ATP [sulfur carrier] Rv0488 aminotransferase biosynthesis I L-cysteine biosynthesis V (mycobacteria) a 2-O-( -D-mannosyl)-1- cholesterol glycyl-[protein] CoA CoA shikimate reductoisomerase: DapD: dapD Probable 3- phosphate 3- isomerase: dihydrolipoamide bkdB bkdA Probable 3-oxoacyl- 3-phosphate phosphoribulosylformimino- phosphatidyl-1D-myo-inositol Cysteine ilvC hydrogencarbonate ArgD: argD [+ 2 isozymes] rpiB dehydrogenase: ethionamide very-long-chain 1-acylglycerol- methionine cholest-4-en- Rv1966 AICAR-phosphate (2Z)-2-aminobut- oxoacyl-[acyl- a [phospholipid] epimerase: [acyl-carrier protein] Probable Probable shikimate cholesterol 3-oxoacyl-(acyl 3-phosphate O- aminopeptidase: desulfurase: L-homoserine 2-enoate N-succinyl-2-amino- L-homoserine carrier protein] cyclopropane rpe lpdC ethionamide S- cholesterol reductase: fabG4 dephospho- 3-one C26 Shikimate glu iscS NADPH (2R)-2,3- N-acetyl-L- 6-ketopimelate carrier protein) acyltransferase: mapA monooxygenase kinase: a [CysO sulfur-carrier 3-phospho-L-serine reductase: fabG2 fatty acid monooxygenase: dehydrogenase: CoA kinase: dependent Shikimate dihydroxy-3- probable D-ribose 5- cholesterol synthase I: kasA Rv2182c Rv1424c aroK ornithine Probable protein]-thiocarboxylate an [apo BCAA mymA Rv1106c Probable 3-oxoacyl- coaE [(25R)-3- Rv3081 Probable Probable methylbutanoate carbamoyl- (S)-1-pyrroline- methionine Probable 2,4-dienoyl- kinase: Probable N- Probable glutamate [+ 2 isozymes] phosphate an [apo BCAA dehydrogenase6 oxidase: choD 1-myristoyl-2- oxocholest- 5-carboxylate D-xylulose dehydrogenase 6 [acyl-carrier protein] + homoserine cyclase phosphate CysO-thiocarboxylate- phosphatidyl-myo- phosphatidylinositol E2 protein] N [+ 2 isozymes] aminopeptidase: cysteine CoA aroK succinyldiaminopimelate homoserine 5-kinase -S-[2- ethionamide S- a very-long-chain palmitoleoyl- ADP coenzyme A H 4-en-26-oate Rv0833 shikimate 3- HisF: hisF inositol dimannoside 5-phosphate E2 protein] N cholest-5-en-3-one reductase: fabG2 acyl-carrier protein reductase: kinase Probable synthase: superpathway of L-methionine biosynthesis (by sulfhydrylation) aminotransferase: dapC kinase dependent cysteine a (3R)-3- mannoside methylpropanoyl]dihydrolipoyl- sn-glycerol mapB desulfurase phosphate protein: proB -dihydrolipoyl- monooxygenase: cholest-5-en-3-one acyl-carrier protein mono-unsaturated 3- forming]: cyp142 ThrB: thrB dihydroxy-acid 2-iminobutanoate carA carB Probable [sulfur carrier synthase: cysM synthase: pimB acyltransferase: (3R,5Z,8Z,11Z,14Z,17Z)-3- Csd: csd fadH shikimate 3- ThrB: thrB γ-L-glutamyl hydroxyhexadecanoyl-[acp] L-lysine oxo-fatty acyl-[acp] 3-phosphate an N-terminal protein CysO] L-lysine ethA hydroxydocosapentaenoyl-CoA met dehydratase: N-succinyl-L,L-2,6- pyrroline-5- Rv2611c cholest-5-en-3- glycyl-[protein] (25R)-3- Rv2923c 3-phosphoshikimate 1- D-erythro- phosphate 5-phosphate a sulfurated (3E)-undec- MbtF ilvD diaminopimelate carboxylate sulfurtransferase: Transketolase: tkt one isomerase: ala oxocholest- O-phospho- AICAR imidazole-glycerol- carbamoyl oxaloacetate O-phospho- 3-hydroxyacyl- ethionamide S- cholest-5- carboxyvinyltransferase: L-ornithine reductase: moeB1 [sulfur carrier] 4-en-26-oate 3-enoyl-CoA L-homoserine 3-phosphoshikimate 1- phosphate thioester Rv1106c en-3-one aroA phosphate L-homoserine monooxygenase: carboxyvinyltransferase: 3-methyl-2- Probable succinyl- proC Probable dehydratase: htdX D-sedoheptulose D-glyceraldehyde isomerase: Rv3369 Probable aspartate ethA2 oxobutanoate diaminopimelate gamma- a 2,6-di-O-(α-D-mannosyl)-1- 7-phosphate 3-phosphate cholesterol 5-enolpyruvoyl- Threonine aroA Threonine a [CysO sulfur-carrier a [CysO sulfur-carrier protein]- dihydrolipoyllysine- ethionamide Rv1106c Probable 2-oxobutanoate aminotransferase: glutamyl [+ 3 isozymes] oxidase: choD Rv1158c shikimate 3- synthase: desuccinylase phosphatidyl-1D-myo-inositol a 2-O-(6-O-acyl-α-D-mannosyl)- residue (2- Rv0580c imidazole 5-enolpyruvoyl- ornithine aspC synthase: protein]-Gly-Gly-adenylate Gly-NH-CH 2 -C(O)-S-L-cysteine S-oxide 1-palmitoyl- an N-terminal-L-methionyl- 5’-chloro-5’- a peptide with (2E,4E)- phosphate thrC DapE: dapE pro phosphate 1-phosphatidyl-1D-myo-inositol methylpropanoyl) cholesterol a [formate C glycerol- shikimate 3- 2-isopropylmalate carbamoyltransferase, thrC CysO-cysteine phosphatidylinositol SAM a reduced flavodoxin AsbD acyl-carrier protein coenzyme A a palmitoleoyl-[acp] sn-glycerol L-cysteinyl-[protein] deoxyadenosine an N-terminal tetradeca-2,4- Branched-chain Probable reductase a (2E)-hexadec-2-enoyl-[acp] Probable transferase: bkdC cholest-4-en-3-one oxidase: choD acetyltransferase]-glycine ATP phosphate synthase: leuA anabolic: argF Possible aspartate hydrolase: mec dimannoside phosphatidyl-myo- ethionamide S- 3-phosphate L-methionine dienoyl-CoA Probable phosphate protein: proA transaldolase methionine Probable purine amino acid acetolactate acyltransferase: inositol dimannoside monooxygenase: holo-[acyl- 1-acylglycerol- Methionine RipA thr dehydratase aminotransferase: L,L-diaminopimelate Tal: tal Probable chorismate transaminase synthase: ilvG thr carrier protein] aminopeptidase: nucleoside aminopeptidase: Probable HisB: hisB Probable aspB Rv2611c synthase: pimB mymA cholest-4-en-3-one pyruvate 3-phosphate O- Adenylyl Rv1914c synthase: (2S)-2- IlvE: ilvE palmitoyl-[acp] synthase: acpS mapA phosphorylase: mapA NADPH Rv3520c chorismate L-glutamate-5- [sulfur carrier formate lyase acyltransferase: cyclase (ATP [+ 3 isozymes] reductase: fas cholest-4- aroF isopropylmalate L-citrulline Probable semialdehyde ethionamide S- cholest-4-en- Rv2182c deoD dependent Probable synthase: protein CysO] D-erythrose en-3-one 26- cholest-4- activating methionine pyrophosphate- imidazole acetol- (S)-2-aceto-2- diaminopimelate F6P 2-oxoglutarate decarboxylation to succinyl-CoA monooxygenase: 3-one C26 phosphopantetheinyl Methionine 2,4-dienoyl- L-serine aroF asp adenylyltransferase: 4-phosphate monooxygenase: protein: pflA 1-palmitoyl-2- lyase) (adenylate gln phosphate en-3-one 26- transferase: pptT aminopeptidase: 5-chloro-5- CoA chorismate probable 3- hydroxybutanoate epimerase: dapF α ethA monooxygenase aminopeptidase: dehydratase: val moeB1 a palmitoyl-[acp] a 2-O-(6-O-acyl- -D-mannosyl) cyp125 monooxygenase: a [formate C palmitoleoyl- mapB adenine deoxyribose cyclase): Rv1264 Rv1838c isopropylmalate Probable [(25R)-3- a flavodoxin a holo-[AsbD acyl- acyl-carrier protein mapB reductase: sdaA -6-O-(α-D-mannosyl)-1- a [2-oxoglutarate cyp125 met 5’-deoxyadenosine acetyltransferase]- 3’,5’-ADP sn-glycerol 1-phosphate Rv0504c Probable histidinol- chorismate dehydratase: Probable argininosuccinate Aspartokinase: [CysO sulfur-carrier protein] Transketolase: tkt ethionamide S- oxocholest- semiquinone carrier protein] fadH Rv2081c meso-diaminopimelate L-arginine biosynthesis II (acetyl cycle) phosphatidyl-1D-myo-inositol dehydrogenase 6 glycin -2-yl radical 3-phosphate an N-terminal L- [+ 6 isozymes] phosphate leuD leuC KETOL-acid synthase ask trans,octacis-decaprenyl phosphate monooxygenase: 4-en-26-oate met a peptide met (S)-1-pyrroline- E2 protein] N (25S)-26-hydroxycholest- (25S)-26- cysteinyl-[protein] cyclic-AMP (3E)-tetradec- possible Probable aminotransferase reductoisomerase: ArgG: argG dihydrolipoamide ethA2 forming]: cyp142 Chorismate 5-carboxylate 3-oxo- D-glyceraldehyde -lipoyl-L-lysine 4-en-3-one hydroxycholest- 3-enoyl-CoA anthranilate threonine HisC1: hisC1 ilvC N-acetylglutamyl- dehydrogenase: mutase: 2-isopropylmaleate Diaminopimelate stearoyl-[acp] 3-phosphate 4-en-3-one synthase: dehydratase L-arginino- L-aspartyl- polyprenyl-phosphate β- (2-ethylpyridin- Rv0948c phosphate synthase: fas lpdC Rv0354c 4-phosphate sulfate decarboxylase: lysA Probable D-mannosyltransferase: dihydrolipoamide 4-yl)(imino) cholest-4- LipR trpG trpE IlvA: ilvA (R)-2,3-dihydroxy- succinate a 2-O-(6-O-acyl-α-D- LppK Probable histidinol- pyrroline-5- glyoxylate cycle en-3-one 26- (25R)-26-hydroxycholest- cholest-4- probable 3- 3-methylpentanoate palmitate ppm1 α dehydrogenase: methanesulfinate phosphate Chorismate mannosyl)-6-O-[ -D-mannosyl- monooxygenase: 4-en-3-one en-3-one 26- an odd numbered 1-stearoyl- an N-terminal-L-methionyl- a (3R,7Z,10Z a (2E,4E)-alka- (2Z)-2-aminobut- argininosuccinate probable: carboxylate lpdC an oxidized ferredoxin 3-oxododecanoyl-CoA isopropylmalate Aspartate- lys Probable N- (1->6)-α-D-mannosyl]-1- glu straight chain a palmitoyl-[acp] sn-glycerol L-threonyl-[protein] a stearoyl-[acp] 2,4-dienoyl-CoA aminotransferase: mutase: reductase: trans,octacis- ethionamide S- cyp125 monooxygenase: ,13Z,16Z,19Z)-3- 2-enoate dehydratase: Probable lyase: argH cysD cysN acyl-CoA [iron-sulfur] cluster anthranilate hisC2 Rv1885c semialdehyde acetyl-gamma- a 3-oxooctadecanoyl-[acp] decaprenylphospho-β-D-mannose phosphatidyl-1D-myo-inositol monooxygenase: cyp125 2,3,4-saturated 3-phosphate hydroxydocosa- proC synthetase: succinate a [2-oxoglutarate a [2-oxoglutarate methionine Probable stearoyl-[acyl- leuD leuC dihydroxy-acid dehydrogenase: glutamyl- cholest-4-en- Probable ferredoxin- fatty acid 1-acylglycerol- Probable acetyl-CoA glyoxylate dehydrogenase dehydrogenase mymA (25S)-26-oxocholest- acyl-CoA aminopeptidase: beta-ketoacyl 7,10,13,16,19- Rv1068c LprA dehydratase: fadD32 6 6 3-one C26 carrier protein] NADPH Rv1800 L-histidinol asd APS phoshate 4-en-3-one (25S)-26-oxocholest- dependent 3-phosphate O- pentaenoyl-[acp] Probable anthranilate prephenate ilvD arg Probable 3- E2 protein] N E2 protein] N -S- monooxygenase synthetase: mapA CoA thiolase desaturase: desA2 (2R,3S)-3- reductase ethionamide S- 4-en-3-one glutamate synthase acyltransferase: 3-hydroxyacyl- dependent phosphoribosyltransferase phosphate Probable pro [+ 21 isozymes] oxoacyl-[acyl- Malate synthase -dihydrolipoyl- succinyldihydrolipoyl- fadD32 FadA3: fadA3 isopropylmalate ArgC: argC isocitrate lyase: icl1 [(25R)-3- [NADPH] (large Rv2182c thioester 2,4-dienoyl- TrpD: trpD L-aspartate 4- G GlcB: glcB L-lysine L-lysine monooxygenase: cholest-4- methionine 2-iminobutanoate prephenate (S)-3-methyl-2- adenylylsulfate acetylglutamate carrier protein] oxocholest- an odd numbered 1-stearoyl- stearoyl-[acyl- dehydratase: CoA histidinol- semialdehyde [+ 2 isozymes] ethA en-3-one 26- cholest-4- subunit): gltB [+ 21 isozymes] [+ 2 isozymes] dehydrogenase: Probable 3- oxopentanoate kinase: cysN kinase ArgB: argB palmitoyl-CoA reductase: fabG2 a 2-O-(6-O-acyl-α-D-mannosyl)- 4-en-26-oate aminopeptidase: carrier protein] N-(5- monooxygenase: en-3-one 26- straight chain 2-palmitoyl- htdX reductase: phosphatase: α α + diphosphate AMP acyl-carrier protein mapB HsdM tyrA isopropylmalate gln N-acetyl-L-glutamate 6-O-[ -D-mannosyl-(1->6)- -D- forming]: cyp142 a reduced ferredoxin sn-glycerol acetyl-CoA decanoyl-CoA desaturase: desA1 fadH Crp Rv2853 phosphoribosyl) glu N-acetyl-L-glutamate palmitoleate ethionamide S- cyp125 monooxygenase: H gln 2-oxoglutarate 2,3,4-saturated hisN Branched-chain Probable [+ 2 isozymes] mannosyl-(1->6)-α-D-mannosyl]- [iron-sulfur] cluster [+ 3 isozymes] -anthranilate dehydrogenase: 5-semialdehyde biosynthesis II monooxygenase: cyp125 fatty acyl CoA 3-phosphate an N-terminal L- docosapentaenoyl- 3-(4- homoserine PAPS L-glutamate N- dihydrolipoamide met an oleoyl-[acp] leuB amino acid superpathway of L-serine 1-phosphatidyl-1D-myo-inositol threonyl-[protein] 2-enoyl [acp] a (3E)-alk-3- hydroxyphenyl) L-alanine Probable (plants and bacteria) ethA2 (25S)-3-oxocholest- (25R)-26-oxocholest- histidinol transaminase dehydrogenase acetyltranferase: probable and glycine biosynthesis I a (3R)-3- dehydrogenase: biosynthesis III 4-en-26-oate (25S)-3-oxocholest- enoyl-CoA pyruvate ThrA: thrA argA acetylornithine hydroxyoctadecanoyl-[acp] phosphatidylinositol lpdC 4-en-3-one 2-oxobutanoate (2S)-2-isopropyl- IlvE: ilvE Probable 3’- carbamoyl- aminotransferase tetramannoside α-(1-2) D-threo-isocitrate (S)-malate 2-ethyl-4- 4-en-26-oate Rv3866 3-oxosuccinate phosphoadenosine phosphate a palmitoyl-[acp] Rv3363c Probable histidinol ArgD: argD 3-phospho-D-glycerate -mannosyltransferase: amidopyridine 5’-phosphosulfate synthase: 3-hydroxyacyl- cholest-4-en- Rv3209 1-(o- Probable dehydrogenase: cys L-homoserine possible acyl-[acyl- acyl-CoA a 2-methyl ile Probable thioester pimE malate 3-one C26 1-stearoyl- peptidoglycan peptidoglycan an insertion a 2-trans-4-cis carboxyphenylamino) hisD reductase: cysH carA carB Possible D-3- carrier protein] acyl-CoA synthetase: 3-oxooctanoyl-CoA cholesterol acetolactate isoniazid branched 2,3,4- a stearoyl-[acp] sn-glycerol tetrapeptide, tetrapeptide, sequence -dienoyl-CoA -1’-deoxyribulose Probable glutamate N- phosphoglycerate dehydratase: htdX a 2-O-(6-O-acyl-α-D-mannosyl) desaturase: desA2 D-threo-isocitrate dehydrogenase: mdh synthetase: monooxygenase fadD32 2-methyladenine synthase: ilvG activation adenosylcobinamide-GDP saturated fatty acid 3-phosphate glycan chain 1 glycan chain 2 element IS30 5’-phosphate cysteine Probable acetyltransferase dehydrogenase: serA2 -6-O-[α-D-mannosyl-(1->2) hydro-lyase fadD32 [(25R)-3- ribotide phosphate Probable histidinal tyr sulfite L-ornithine [+ 3 isozymes] [NAD] dependent acyl-CoA 1-acylglycerol- L,D- cholesterol C26 Possible Probable RplU [+ 3 isozymes] 4-methyl-2- L-phenylalanine desulfurase homoserine O- carbamoyl phosphate ArgJ: argJ -α-D-mannosyl-(1->6)-α-D- probable acyl-[acyl- (cis-aconitate- ETH-NAD- oxocholest- beta-ketoacyl Rv2307c malate 3-oxocholest- probable synthetase: 3-phosphate O- transpeptidase monooxygenase transposase NADPH Probable oxopentanoate biosynthesis I Csd: csd acetyltransferase: Probable D-3- mannosyl-(1->6)-α-D-mannosyl]- carrier protein] forming): acn imine adduct 3-oxocholest-4- 4-en-26-oate CoA thiolase Rv3901c (S)-2-aceto-2- a (2E)-octadec-2-enoyl-[acp] isoniazid 4-en-26-oate- cobalamin 5’- fadD32 4: Rv0192 [(25R)-3β- dependent Probable histidinol phosphoglycerate oxidoreductase: mez forming]: cyp142 acyltransferase: (fragment) indole-3- metA N-acetyl-L-ornithine 1-phosphatidyl-1D-myo-inositol desaturase: desA1 en-26-oate--CoA -CoA ligase: phosphate FadA3: fadA3 hydroxybutanoate dehydrogenase: Branched-chain isoniazide Rv2182c hydroxycholest- : Rv0606 2,4-dienoyl- glycerol Cysteine dehydrogenase: serA1 ligase: fadD19 fadD19 [+ 21 isozymes] Probable L,D- amino acid L-alanine chorismate a palmitoleoyl-[acp] peroxidase: synthase: cobS a 2-methyl 1-stearoyl-2- 5-en-26-oate CoA phosphate hisD desulfurase: cis-aconitate acetyl-CoA oxaloacetate Coα-[α-(2-methyladenin-9- [+ 2 isozymes] Probable biosynthesis I O-acetyl-L- 3-phosphooxypyruvate katG (25R)-3-oxocholest- stearoyl-sn transpeptidase forming]: cyp142 [+ 56 isozymes] reductase: Rv2084 transaminase chorismate iscS steroyl-[acp] branched an insertion Rv0875c synthase homoserine hydrogen sulfide 4-en-26-oate (25S)-3-oxocholest- GMP yl)]-Coβ-adenosylcobamide AMP diphosphate acyl-carrier protein LdtB: ldtB acetyl-CoA hexanoyl-CoA KETOL-acid IlvE: ilvE mutase: mbtI ornithine reductase: fas isonicotinate 2,3,4-saturated -glycerol 3- β fadH TrpC: trpC 5’-phosphate peptidoglycan (25R)-3 - sequence IS30 reductoisomerase: his 3-methyl-2- ala citrate hydro-lyase ETH-NAD adduct acyl radical 4-en-26-oyl-CoA fatty acyl-CoA phosphate Rv2430c carbamoyltransferase, Possible phosphoserine D-ala DAP-DAP hydroxycholest- with integrated ilvC [+ 2 isozymes] a 2-O-(6-O-acyl-α-D-mannosyl) (cis-aconitate- (25R)-3- (1S,2R)-1- oxobutanoate anabolic: argF aminotransferase: serC 5-en-26-oate transposon a (3E)-alk-3- prephenate a stearoyl-[acp] α oxocholest-4-en- 3-oxocholest-4- crosslink C-(indol-3- leu Branched-chain Probable O- -6-O-[ -D-mannosyl-(1->2) forming): acn enoyl-CoA superpathway of L- α α citrate 26-oate--CoA en-26-oyl-CoA Rv1768 yl)glycerol (R)-2,3-dihydroxy- amino acid acetylhomoserine - -D-mannosyl-(1->2)- -D- palmitoleate Rv0178 asparagine biosynthesis α synthase: gltA2 ligase: fadD19 dehydrogenase: 3-phosphate 3-methylpentanoate transaminase Prephenate sulfhydrylase: metC 3-phospho-L-serine mannosyl-(1->6)- -D-mannosyl- α isonicotinate acyl- fadE27 fadE26 IlvE: ilvE dehydratase (1->6)- -D-mannosyl]-1- Probable citrate 3-oxo-23,24- 3-oxo- (25R)-3-oxocholest- (15Z)- a [DNA]-3’- a 5’-phospho- a 10- EsxU Probable PheA: pheA phosphatidyl-1D-myo-inositol synthase II CitA: citA NADH adduct an oxidized glycerophosphoglycerol cobyrinate probable Phosphoserine/threonine arachidoyl-[acp] tetracosenoate NADPH hydroxyl [DNA] formyltetrahydrofolate- bisnorchol-1,4- dihydroxy-acid L-cysteine asp 4-en-26-oyl-CoA 3-oxocholest-4,24- adrenodoxin ATP H 2 O tryptophan val phosphatase PstP: pstP dien-22-yl-CoA biosynthesis I L-homocysteine L-citrulline synthase: fas citrate dien-26-oyl-CoA acyl-CoA 4a-carbinolamine dehydratase: 3-phenyl-2- (25S)-3- Probable Probable ATP Rv2897c synthase: stearate ATPase: eccB1 Probable MbtC ilvD L-glutamine oxopropanoate [+ 2 isozymes] oxocholest-4- synthetase: dependent Putative 3-oxo-23,24- trpB trpA NADPH:adrenodoxin glycerophosphoryl cobyrinic en-26-oyl-CoA 3-oxocholest- fadD32 ATPase: eccA3 DNA pterin-4-alpha- bisnorchol- biosynthesis I Probable oxidoreductase: fprB diester ser Probable Probable Probable aspartate Probable 5- 4,24-dien- carbinolamine 1,4-dien- acid A,C- (S)-3-methyl-2- ser acyl-CoA racemase: mcr Putative conserved phosphodiesterase: ligase: ligD Rv2353c ser 5-methyltetrahydrofolate- methyltetrahydropteroyltriglutamate-- argininosuccinate a 3-oxoicosanoyl-[acp] [+ 21 isozymes] α diamide indole oxopentanoate asparagine asparagine aminotransferase: synthetase: phthiocerol biosynthesis 26-oyl-CoA NADPH:adrenodoxin dehydratase: 22-CoA 9 - Probable serine synthase phosphatidylglycerol ATPase: Rv0435c glpQ1 synthase synthetase synthetase aspC homocysteine homocysteine methyltransferase: metE hydratase: oxidoreductase: fprA [+ 2 isozymes] Rv1159.1 hydroxylase: Rv2181 acetyltransferase: glu fadD32 biosynthesis II (Z)-15- + DevS AsnB: asnB AsnB: asnB ala methyltransferase: metH ArgG: argG Serine AMP diphosphate kshB kshA CobB: Branched-chain Probable 3- (25S)-3-oxocholest- echA19 + + H phosphate ADP cysE (non-plastidic) tetracosenoyl-CoA a reduced [+ 2 isozymes] [DNA] cobB Probable Possible aspartate 5-methyltetrahydrofolate- hydroxymethyltransferase: [+ 21 isozymes] behenate H NADP 10 [+ 2 isozymes] 9α-hydroxy-3-oxo- amino acid oxoacyl-[acyl- 4-en-26-oyl-CoA adrenodoxin sn-glycerol probable O-acetyl-L-serine glutamine homocysteine glyA2 24-hydroxy-3- glycerol an N - transaminase aminotransferase: L-arginino-succinate carrier protein] behenoyl DHAP 23,24-bisnorchol- tryptophan Alanine methyltransferase: metH 3-phosphate formyldihydrofolate cob(II)yrinate Rv2264c IlvE: ilvE synthetase: aspB stearoyl-CoA reductase: fabG2 3-oxocholest-4- oxocholest-4- 1,4-dien-22-yl-CoA synthase: racemase adenylyltransferase: a,c-diamide asn asn glnA3 Serine Probable glycerol- en-26-oyl-CoA en-26-oyl-CoA Rv2197c trpB trpA Cysteine Alr: alr argininosuccinate fadD26 Rv3882c hydroxymethyltransferase [+ 2 isozymes] 3-phosphate dehydrogenase: synthase a: cysK1 [+ 3 isozymes] met lyase: argH ile phe 1 GlyA1: glyA1 mycocerosic acid dehydrogenase fadE27 fadE26 probable 3- 38- gln D-ala a (3R)-3- [NAD(P)+]: gpdA1 hydroxybutyryl- a 3’-(hydroxy)phthioceranyl- a 3-methyl- a uridine adenylyltransferase: butanoyl-CoA acetyl-CoA an oligopeptide hydroxyicosanoyl-[acp] 3-oxocholest-4,24- CoA 2’-palmitoyl(stearoyl)- branched 2,3,4- a purine 40 in tRNA Ap4A Rv2599 trp cys arg gly fadD28 arsenate dITP dien-26-oyl-CoA dehydrogenase: 2-O-sulfo-α,α-trehalose saturated fatty acid ribonucleoside Rv1126c Probable glycerol- Probable Probable tRNA Probable Rv2819c 3-hydroxyacyl- (behenoyl)adenylate fadB3 acyl-CoA diadenosine 3-phosphate 3’-(hydroxy)phthioceranyl- Probable purine dITP/XTP beta-ketoacyl pseudouridine 1 4 protease thioester 3-oxocholest- synthetase: 5’,5’’’-P ,P - dehydrogenase 2’-palmitoyl(stearoyl)-2-O nucleoside pyrophosphatase: Rv1341 CoA thiolase synthase B: truB II: ptrBa dehydratase: htdX fatty-acid- 4,24-dien-26-oyl- 3,24-dioxocholest- fadD32 tetraphosphate [NAD(P)+]: gpdA2 -sulfo-trehalose (hydroxy) phosphorylase: FadA3: fadA3 AMP ligase: CoA hydratase: 4-en-26-oyl-CoA Nucleoside triphosphate phosphorylase: phthioceranyltransferase: [+ 21 isozymes] deoD Probable tRNA Probable Rv1803c [+ 3 isozymes] fadD26 sn-glycerol a 3-methyl- Rv2613c Rv0449c echA19 Rv3822 pyrophosphohydrolase: [+ 2 isozymes] pseudouridine protease Rv0658c Nucleoside and Nucleotide Biosynthesis 3-phosphate branched ribose-1-arsenate a purine base mazG synthase a: truA a behenoyl-[(phenol) 2’-palmitoyl/stearoyl-2- diphosphate AMP II: ptrBb a (2E)-icos-2-enoyl-[acp] 24-hydroxy-3-oxocholest- a mycobacterial sulfolipid 2,3,4-saturated 3-oxohexanoyl-CoA 38- 3,24-dioxocholest- α α a pseudouridine ADP ATP carboxyphthiodiolenone Probable glycerol- 4-en-26-oyl-CoA O-sulfo- , -trehalose fatty acyl-CoA dIMP a peptide superpathway of pyrimidine synthase] 3-phosphate 4-en-27-oyl- 40 in tRNA superpathway of guanosine superpathway of pyrimidine pyrimidine deoxyribonucleotides superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis superpathway of pyrimidine deoxyribonucleotides superpathway of guanosine trans-eicos- acyltransferase: CoA:coenzyme Rv0102 nucleotides de novo biosynthesis I probable 3- Bcp EsxG de novo biosynthesis (E. coli) nucleotides de novo biosynthesis II adenosine nucleotides ribonucleosides de novo biosynthesis III deoxyribonucleoside salvage 2-enoyl-[acyl- phenolpthiocerol A propanoyl- plsB2 hydroxybutyryl- de novo biosynthesis II salvage II carrier protein] synthesis type- transferase: UDP CTP 2’-deoxycytidine a 1-acyl-sn CoA fadA5 gln hydrogencarbonate CTP cytidine reductase: fas I polyketide (6Z,9Z,12Z,15Z,18Z)-3- a tetramethylated (9Z,12Z)-15,16- D-glycero-D- -glycerol 3- dehydrogenase: 3-oxo-palmitoyl-CoA 1-octanol IMP synthase Pps: oxotetracosapentaenoyl-CoA O-succinyl-L-homoserine mycocerosyl- epoxyoctadeca- manno-heptose IMP asp Probable cytidine Ribonucleoside- phosphate fadB3 IMP ppsA ppsB a phthiodiolone XTP 7-phosphate FixB diphosphate Probable acetyl-CoA [mycocerosic 9,12-dienoate Rv1443c probable carbamoyl- deaminase: cdd CDP Probable an arachidoyl-[acp] ppsC ppsD ppsE cystathionine gamma- Probable Possible zinc- Rv3194c reductase (beta 3-oxochol-4- acid synthase] Possible cytidine 1-acylglycerol- 3,24-dioxocholest- propanoyl-CoA acyltransferase: fadA2 synthase: metB dITP/XTP beta-ketoacyl Possible phosphate inosine-5’- en-24-oyl-CoA phthiodiolone epoxide containing alcohol Possible cytidine/ chain): nrdF2 3-phosphate O- 4-en-26-oyl-CoA pyrophosphatase: Rv1341 D-alpha-D- synthase: carA carB inosine-5’- deaminase: dCMP dimycocerosyl CoA thiolase dehydrogenase CDP monophosphate Probable Ribonucleoside- 3-oxo- a C34- Probable beta- hydrolase: monophosphate deoxycytidylate cdd acyltransferase: Probable O- FadA3: fadA3 heptose-7- dehydrogenase: adenylosuccinate [+ 4 isozymes] behenoyl-[acp] 3-oxochol-4- transferase: Nucleoside triphosphate ephF NAD dependent dehydrogenase: deaminase: Rv3752c diphosphate carboxyphthiodiolenone- Rv2182c ketoacyl CoA succinylhomoserine phosphate guaB1 synthetase: purA dUDP Cytidylate synthase: fas [(phenol) en-24-oyl-CoA thiolase FadA3: fadA3 papA5 pyrophosphohydrolase: AdhB: adhB Rv0862c carbamoyl phosphate asp Ribonucleoside- Ribonucleoside- guaB1 uridine reductase (beta 3,24-dioxocholest- sulfhydrylase: metZ a holo- [+ 2 isozymes] kinase RslA Possible cytidine/ kinase: cmk carboxyphthiodiolenone a 1,2-diacyl- dehydrogenase: a dimycocerosyl mazG [+ 6 isozymes] Rv0598c diphosphate diphosphate chain): nrdF2 4-en-27-oyl- (4Z,7Z,10Z,13Z,16Z)- [mycocerosic (9Z,12Z)-15,16- HddA: hddA [+ 2 isozymes] deoxycytidylate synthase] sn-glycerol fadE34 acetyl-CoA phthiodiolone myristoyl-CoA acetyl-CoA [+ 5 isozymes] reductase (beta reductase (beta [+ 2 isozymes] adenylo-succinate uridine Probable dCDP a 3-oxodocosanoyl-[acp] CoA:coenzyme docosapentaenoyl-CoA succinate L-homocysteine acid synthase] dihydroxyoctadeca- D-glycero-α-D- [+ 4 isozymes] deaminase: 3-phosphate XMP 1-octanal chain): nrdB chain): nrdF2 nucleosidase: iunH nucleoside A propanoyl- 9,12-dienoate manno-heptose Probable aspartate XMP Rv3752c 3-oxochol-4,22- XMP diphosphate dCDP C34- transferase: fadA5 1,7-bisphosphate carbamoyltransferase: pyrB [+ 3 isozymes] [+ 4 isozymes] Probable Probable Probable integral dien-24-oyl-CoA Rv1979c uracil kinase: ndkA Probable 3- carboxyphthiodiolenone DnaA adenylosuccinate nucleoside membrane UDP oxoacyl-[acyl- A-[phthiodiolenone Rv3507 dCDP GMP synthase lyase: purB Probable 2’-deoxyuridine diphosphate phosphatidate GMP synthase dUTP carrier protein] synthase] nucleoside kinase: ndkA C30-mycocerosyl- N-carbamoyl-L-aspartate [glutamine- reductase: fabG2 cytidylyltransferase: 3-oxochol-4-en-24-oyl-CoA propanoyl-CoA 3-oxopentanoyl- sn-glycerol a supercoiled (3R,5S)-3- Probable [glutamine- diphosphate thioesterase: tesA coenzyme A C35- octanoyl-CoA acetyl-CoA formate Ribonucleoside- Ribonucleoside- hydrolyzing]: guaA cdsA [EntF L-seryl-carrier protein] [mycocerosic CoA 3-phosphate duplex DNA hydroxy-1- hydrolyzing]: guaA Probable deoxyuridine kinase: ndkA 22-hydroxy-3-oxochol- phenolphthiocerol A ITP nucleoside diphosphate diphosphate AMP dCTP [+ 2 isozymes] acid synthase] pyrroline-5- FtsE 5’-triphosphate C34- holo-[acyl-carrier Possible acetyl-CoA Probable Probable glycerol- Rv1144 diphosphate reductase (beta reductase (beta 3-oxochol-4- 4-en-24-oyl-CoA phenolphthiocerol/ Probable carboxylate Probable nucleotidohydrolase: dut a CDP- acetyltransferase dITP/XTP kinase: ndkA GMP dCTP carboxyphthiodiolenone en-24-oyl-CoA protein] synthase: acpS beta-ketoacyl 3-phosphate replicative dihydroorotase: pyrC chain): nrdB chain): nrdF2 GMP dUMP thymidine a (3R)-3- diacylglycerol phthiocerol/ pyrophosphatase: Rv1341 Probable Rv2972c dehydrogenase: (acetoacetyl-CoA CoA thiolase acyltransferase: DNA hydroxydocosanoyl-[acp] Phosphopantetheinyl phthiodiolone pyrroline-5- Adenylate Nucleoside triphosphate thiolase): Rv1135A FadA3: fadA3 [+ 3 isozymes] [+ 4 isozymes] dTMP fadE34 Nucleoside triphosphate plsB2 helicase carboxylate kinase: adk Probable CDP- transferase: pptT dimycocerosyl (S)-dihydroorotate Probable pyrophosphohydrolase: synthase: 1-(18- DnaB: dnaB Rv0227c Probable diacylglycerol--glycerol- transferase: papA5 [+ 4 isozymes] pyrophosphohydrolase: [+ 2 isozymes] reductase: Rv2648 dCTP dUDP guanylate mazG thyA 3-hydroxybehenoyl- 3-oxochol-4,22- 3,22-dioxochol- 3’,5’-ADP a holo-[EntF L-seryl-carrier protein] hydroxyoleoyl) guanylate superpathway of 3-phosphate 3- a holo- mazG proC kinase Gmk: gmk [acyl-carrier dien-24-oyl-CoA 4-en-24-oyl-CoA C95-dimycocerosyl propanoyl-CoA acetyl-CoA 3-oxodecanoyl-CoA -sn-glycrol [+ 8 isozymes] dihydroorotate kinase Gmk: gmk adenosine nucleotides C33-phthiodiolenone A phosphatidyltransferase: [mycocerosic Probable Probable ADP dUMP protein] phenolphthiocerol IMP 3-phosphate a single Hyp GlnH de novo biosynthesis I acid synthase] dehydrogenase: pyrD deoxycytidine nucleoside dehydratase: pgsA2 stranded DNA UTP triphosphate diphosphate GDP flavin-dependent dTMP hadA hadB C33- GDP 3,22-dioxochol- Rv3166c orotate PRPP deaminase: dcd kinase: ndkA thymidylate phthiodiolenone Rv0830 Ribonucleoside- Ribonucleoside- IMP asp Probable synthase: thyX dTMP [+ 4 isozymes] A reductase: 4-en-24-oyl- diphosphate diphosphate PGP 22-hydroxy-3-oxochol- kinase: tmk Rv2953 CoA:coenzyme reductase (beta reductase (beta Probable synthase: 4-en-24-oyl-CoA 3-oxo-2-(cis- an organic Probable orotate A acetyl- an L-phenylalanyl-Phe an L-tyrosyl-Tyr a 3-oxo acid succinyl-CoA pyridoxal 3-oxo-myristoyl-CoA allysine Rv2162c dTMP pgsA3 [EntB aryl-carrier protein] coenzyme A 2’-pentenyl)- hydroperoxide Probable Ribonucleoside- chain): nrdB chain): nrdF2 adenylosuccinate a (2E)-docos-2-enoyl-[acp] transferase: [tRNA ] [tRNA ] phosphoribosyltransferase: dUTP Probable Ribonucleoside- dTDP Ribonucleoside- synthetase: purA cyclopentane-1-(3R- Rv0290 pyrE nucleoside diphosphate C33-phthiodiolone A fadA5 holo-[acyl-carrier probable succinyl- Probable 3-oxoacyl- Probable Probable Probable thiol Rv1582c nucleoside diphosphate diphosphate [+ 4 isozymes] 1-(3-sn- cyclo(L- hydroxyhexanoyl)-CoA diphosphate reductase (beta [+ 3 isozymes] dTMP kinase: tmk adenylo-succinate protein] synthase: acpS [acyl-carrier protein] beta-ketoacyl piperideine-6- peroxidase CMP diphosphate reductase (beta reductase (beta Probable CoA:3-ketoacid- steroid Probable deoxyuridine kinase: ndkA chain): nrdF2 phosphatidyl) tyrosyl-L- reductase: fabG4 CoA thiolase Tpx: tpx phosphorylation nucleoside [+ 2 isozymes] coenzyme A carboxilic acid enoyl-CoA orotidine 5’-phosphate 5’-triphosphate kinase: ndkA chain): nrdF2 chain): nrdB trans-docos- trans-docos- phthiodiolone -sn-glycerol 3,22-dioxochol- phosphopantetheinyl phenylalanyl) dADP dTDP Probable transferase: FadA3: fadA3 dehydrogenase: nucleotidohydrolase: dut diphosphate 2-enoyl-[acyl- 2-enoyl-[acp] ketoreductase: 3-phosphate 4-en-24-oyl-CoA transferase: pptT synthase: hydratase: EspC [+ 4 isozymes] fatty acid elongation -- saturated Probable 3-oxoacyl- pcd Probable CMP [+ 4 isozymes] [+ 3 isozymes] adenylosuccinate kinase: ndkA Rv2951c scoB scoA echA9 carrier protein] isomerase: 3-oxo-4-pregnene- Rv2275 [acyl-carrier protein] 3-oxo-2-(cis- Rv0677c Probable Probable lyase: purB acetyl-CoA [+ 2 isozymes] peroxiredoxin Rv0878c Probable orotidine Cytidylate Nucleoside triphosphate reductase: fas echA10 3’,5’-ADP a holo-[EntB aryl-carrier protein] cyclo(L- GTP 20-carboxyl-CoA Phe Tyr a 2,3,4-saturated reductase: fabG2 2’-pentenyl)- AhpE: ahpE kinase: cmk nucleoside nucleoside C33-phthiotriol A succinate acetyl-CoA lauroyl-CoA 5’-phosphate pyrophosphohydrolase: GTP ATP pyrimidine deoxyribonucleotides dTTP 3,22-dioxochol- a tRNA a tRNA phenylalanyl- 3-oxoacyl-CoA L-2-aminoadipate cyclopentane-1-(E- diphosphate diphosphate an acetoacetyl-[acp] decarboxylase: pyrF CDP mazG dGDP biosynthesis from CTP trans-docos- 4-en-24-oyl- 3-oxo-23,24- L-tyrosyl) 4-pyridoxolactone hexa-2-enoyl)-CoA an alcohol dGDP kinase: ndkA kinase: ndkA AMP an L-1- 2-enoyl-[acp] C33-phthiotriol CoA:coenzyme bisnorchol-4- DsbE UMP dUMP a behenoyl-[acp] phosphatidyl- Probable Probable CTP isomerase: methyltransferase: A acetyl- en-22-oyl-CoA Rv3621c dTTP sn-glycerol Rv3821 nucleoside nucleoside Probable echA11 Rv2952 transferase: fadA5 dehydrogenase: Cytidylate kinase: cmk dTMP nucleoside Adenylate adenine and adenosine salvage II (1S,2R)-1- 3-oxo-2-(cis- an organic diphosphate diphosphate 3-oxo- fadE29 fadE28 a ferrocytochrome vernolate synthase: thyA kinase: adk an apo [peptidyl-carrier protein] coenzyme A a 2,3,4-saturated a 2,3,4-saturated 2- carbonic acid Probable uridylate kinase: ndkA kinase: ndkA diphosphate [+ 2 isozymes] episterol C-(indol-3- 2’-pentenyl)- molecule lignoceroyl-[acp] C34-phthiocerol A fatty acyl-[acp] lysophosphatidate b 5 ser kinase: ndkA 3-oxo-4,17- yl)glycerol cyclopentane-1-(3R- kinase: pyrH dTMP CDP synthase: fas a 3-oxoacyl-[acp] holo-[acyl-carrier Probable transmembrane Possible chloride LpqP CTP dATP a (3Z)-docos-3-enoyl-[acp] pregnadiene-20- 1-acylglycerol- Membrane- 3-phosphate hydroxybutanoyl)-CoA Ffh 3-oxo-4-pregnene- protein] synthase: acpS carbonic anhydrase probable epoxide steroid peroxidase: Rv1661 UDP adenine and adenosine salvage III ADP adenosine acetyl-CoA carboxyl-CoA 3-phosphate O- bound C- 20-carboxyl-CoA (carbonate hydrolase: Rv3177 dTMP kinase: tmk dGTP Ribonucleoside- a 3-oxotetracosanoyl-[acp] acyltransferase: tryptophan enoyl-CoA inosine phosphopantetheinyl 5 sterol ephF Rv2182c dehydratase) (carbonic synthase: hydratase: diphosphate cis-docos-3-enoyl- 3-oxo-23,24- transferase: pptT desaturase: chloride nucleosidase: 3-oxoacyl- 3-oxo-23,24- dehydratase): Rv3273 trpB trpA echA9 dTDP reductase (beta Ribonucleoside- [acyl-carrier bisnorchol- a 2,3,4-saturated erg3 [+ 6 isozymes] 3-oxo-2-(cis- iunH Probable 3- [acyl bisnorchol-4- D-glyceraldehyde peroxidase: Ribonucleoside- dGTP chain): nrdF2 adenine diphosphate phosphatidylglycerol a holo [peptidyl-carrier protein] 3’,5’-ADP 1,2-diacyl-sn ergosta- (9Z)-12,13- PepD Rv0754 protein]:malonyl- fatty acid 4,17(20)-dien- acyl-carrier protein a ferricytochrome trp 2’-pentenyl)- hpx Rv0601c adenine oxoacyl-[acyl- biosynthesis I (plastidic) carrier en-22-oyl-CoA CO 2 H 2 O 3-phosphate diphosphate reductase superpathway of 5-aminoimidazole reductase (beta [acyl-carrier protein] synthase: 22-oyl-CoA -glycerol 3- 5,7,24(28) dihydroxyoctadeca- cyclopentane-1-(E- Probable [+ 4 isozymes] Probable purine carrier protein] protein] dehydrogenase: b 5 β an organochlorine Probable nucleoside (beta chain): nrdF2 ribonucleotide biosynthesis chain): nrdF2 malonyltransferase: fas hydratase: phosphate -trien-3 -ol 9-enoate buta-2-enoyl)-CoA nucleoside nucleoside reductase: fabG2 synthase fadE29 fadE28 compound diphosphate kinase: ndkA dCDP kasA DHAP Rv3542c [+ 4 isozymes] diphosphate phosphorylase: deoD [+ 4 isozymes] III: fabH [+ 2 isozymes] Adenine Rv3541c kinase: ndkA PRPP superpathway of pyrimidine adenosine [+ 2 isozymes] 3-oxo-4,17-pregnadiene- Rv0420c phosphoribosyltransferase: apt [+ 2 isozymes] Probable glycerol- ParB nucleobases salvage 20-carboxyl-CoA Rv0595c dADP a (3R)-3- 3-phosphate fatty acid a (3R)-3- 1-cis-vaccenoyl- a (7Z,10Z,13Z,16Z 3-oxo-4-pregnene- 3-oxo-2-(cis- dTTP Amidophosphoribosyltransferase: purF Probable a 2,3,4-saturated 17-hydroxy-3- an N-modified L(or D)-O- dUDP a (5Z)-3-oxotetracos- dehydrogenase synthase: an apo-[aryl-carrier protein] coenzyme A a palmitoleoyl-[acp] ,19Z)-3-oxodocosa- a 3-oxodocosanoyl-[acp] 2’-pentenyl)- uracil nucleoside hydroxytetracosanoyl-[acp] hydroxyacyl-[acyl- oxo-4-pregnane- sn-glycerol- aminoacyl-[tRNA] 20-carboxyl-CoA phosphoserine [NAD(P)+]: gpdA1 fatty acyl-[acp] fas 7,10,13,16,19-pentaenoyl-[acp] gln 5-phospho-β- diphosphate Probable adenosine AMP 5-enoyl-[acp] carrier protein] 3-oxo-23,24- 20-carboxyl-CoA 3-phosphate cyclopentane-1-(3R- Probable uracil dCMP holo-[acyl-carrier Probable 3-oxoacyl- 3-oxo-behenoyl- 3-oxo-23,24- UTP Probable nucleoside D-ribosylamine deaminase: add Probable 3-hydroxyacyl- fatty acid bisnorchol- 1-acylglycerol- Probable Phosphoserine/ hydroxyoctanoyl)-CoA kinase: ndkA protein] synthase: acpS [acyl-carrier protein] [acp] reductase: bisnorchol-4- diphosphate kinase: ndkA phosphoribosyltransferase: upp nucleoside synthase: 3-phosphate O- threonine steroid Rv2298 thioester cis-delta5-3- Probable glycerol- 4,17(20)-dien- peptidyl- α Rv1398c UMP Possible cytidine/ fas 3-oxo-23,24- acyltransferase: reductase: fabG2 fabG1 en-22-CoA 9 - phosphatase enoyl-CoA Rv0532 Probable diphosphate dehydratase: htdX oxo-C24:1-[acp] 3-phosphate 22-oyl-CoA phosphopantetheinyl tRNA Probable CTP dUTP deoxycytidylate bisnorchol- Rv2182c hydroxylase: PstP: pstP hydratase: guanine and guanosine salvage II phosphoribosylamine- dCTP inosine kinase: ndkA reductase: fabG1 dehydrogenase hydratase: transferase: pptT [+ 2 isozymes] hydrolase [+ 3 isozymes] synthase PyrG: pyrG Cytidylate kinase: cmk [+ 3 isozymes] 4-en-17-ol- kshB kshA echA9 -glycine ligase: purD deaminase: [+ 3 isozymes] Rv3542c 1-cis-vaccenoyl- a (3R,7Z,10Z,13Z,16Z Pth: pth xanthine and [NAD(P)+]: gpdA2 22-oyl-CoA a (3R)-3- [+ 2 isozymes] 3-oxo-2-(cis- Probable deoxyuridine Rv3752c [+ 3 isozymes] a holo-[aryl-carrier protein] 3’,5’-ADP 2-palmitoleoyl- ,19Z)-3-hydroxydocosa- 9α-hydroxy-androst- xanthosine Probable uridylate Rv3541c hydroxydocosanoyl-[acp] 2’-pentenyl)- dATP sn-glycerol lyase: ltp2 acyl-carrier protein an N-modified an uncharged Rv2325c CTP 5’-triphosphate kinase: pyrH Probable purine a trans-tetracos-2-enoyl-[acp] sn-glycerol- 7,10,13,16,19-pentaenoyl-[acp] 4-en-3-one-17- serine Rv3239c salvage GAR a (3R,5Z)-3-hydroxytetracos- 3-phosphate amino acid tRNA cyclopentane-1-(E- nucleotidohydrolase: dut guanosine dUMP nucleoside 3-phosphate propanoyl-CoA 17-hydroxy-3-oxo-4- octa-2-enoyl)-CoA Rv3439c UDP 5-enoyl-[acp] androst-4-ene- phosphorylase: deoD propanoyl-CoA guanosine Probable Probable 5’- trans-tetracos- Probable glycerol- pregnane-20-carboxyl-CoA Nucleoside triphosphate xanthosine guanine and guanosine salvage dTMP adenine and adenosine salvage I 3,17-dione phosphoribosylglycinamide phosphoribosylglycinamide a trans-2- pyrophosphohydrolase: nucleosidase: Probable nucleoside synthase: thyA 2-enoyl-[acp] a cis-delta5-3- 3-phosphate a 2,3,4-saturated fatty acid formyltransferase 2: purT formyltransferase: purN enoyl-[acyl- CDP mazG iunH diphosphate kinase: ndkA hypoxanthine reductase: fas hydroxyC24:1- acyltransferase: fatty acyl-[acp] a peptidoglycan an odd numbered a (3R,6Z)-3- Rv0526 Probable purine synthase: an apo-[LYS2 L-2- a [glutamine- an L-cysteinyl- OpcA dTMP [acyl-carrier plsB2 carrier protein] 3-oxo-23,24- coenzyme A [CysO sulfur- a sulfurated dimer (E. faeciums) 3’,5’-ADP Cys guanine fas ATP straight chain 2,3,4- hydroxyoctadec- nucleoside UTP bisnorchol-4- aminoadipyl-carrier-protein] carrier protein] [sulfur carrier] synthetase]- [tRNA ] Ribonucleoside- dUMP FGAR guanosine adenine and adenosine protein] d: probable saturated fatty aldehyde 6-enoyl-[acp] Rv0159c phosphorylase: a lignoceroyl-[acp] a 1-acyl-sn L-tyrosine PAP diphosphate reductase hadA hadB en-17-ol-22-oyl- holo-[acyl-carrier aldehyde 3-hydroxyacyl- dTMP kinase: tmk Hypoxanthine-guanine adenosine [sulfur carrier penicillin-binding Glutamate- Probable deoD Probable CTP Probable purine Probable purine -glycerol 3- CoA lyase: ltp2 oleate β-oxidation protein] synthase: acpS phosphatase: nrnA (beta chain): nrdF2 phosphoribosyltransferase: hpt salvage VI protein CysO] protein: dacB1 dehydrogenase: thioester peptidyl- dTMP synthase: thyA xanthine Hypoxanthine-guanine phosphoribosylformylglycinamidine synthase PyrG: pyrG phosphate ammonia-ligase nucleoside nucleoside 3-oxo- 2,3,4-saturated Rv0458 dehydratase: tRNA Rv0541c phosphoribosyltransferase: hpt synthase: purQ dTDP a (2E,5Z)-tetracosa- phosphopantetheinyl adenylyltransferase/ adenylyltransferase: 3(2),5-bisphosphate Rv0386 [+ 4 isozymes] phosphorylase: deoD phosphorylase: deoD cerotoyl-[acp] htdX 1-acylglycerol- fatty acyl- (2E,5Z)- transferase: pptT sulfurtransferase: [+ 2 isozymes] nucleotidase: cysQ hydrolase dTMP CTP 2,5-dienoyl-[acp] glnE [+ 4 isozymes] Phosphoribosylformylglycinamidine guanine adenosine adenine synthase: fas [acp]:NAD+ tetradecenoyl-CoA moeB1 a peptidoglycan tetramer a [glutamine an odd numbered Pth: pth dCDP Probable IMP 3-phosphate O- androst-4-ene-3,17-dione propanoyl-CoA a holo-[LYS2 L-2- EsxP synthase II: purL oxidoreductase: fas 3’,5’-ADP D-ala with a D,D cross-link synthetase]-O straight chain 2,3,4- [+ 3 isozymes] nucleoside acyltransferase: aminoadipyl-carrier-protein] a [CysO sulfur- 4 AMP a (2E,6Z)- Cys dTMP kinase: tmk GMP trans-delta2-cis- an unsulfurated (Enterococcus faecium) -(5’-adenylyl) saturated fatty acid a tRNA Probable nucleoside Adenosine a 3-oxohexacosanoyl-[acp] Rv2182c carrier protein]- octadecadienoyl- cys diphosphate delta5-C24:2- androst-4-en- [sulfur carrier] -L-tyrosine Rv3121 diphosphate kinase: ndkA FGAM Hypoxanthine-guanine kinase: adoK Adenine steroid thiocarboxylate [acp] Rv1132 kinase: ndkA [acp]:NADH+ a 1,2-diacyl- 3,17-dione 1- dTDP XMP phosphoribosyltransferase: hpt phosphoribosyltransferase: apt enoyl-CoA AMP oxidoreductase: sn-glycerol dehydrogenase: dCTP Probable Probable 3- hydratase: dTTP inhA 3-phosphate kstD (3E,5Z)-tetradeca- Rv0872c phosphoribosylformylglycinamidine oxoacyl-[acyl- echA9 Probable nucleoside 3,5-dienoyl-CoA 1-palmitoyl- DNA with adenine:7,8- a (3R,11Z)-3- CYCLO-ligase: purM carrier protein] a peptidoglycan an arachidoyl-[(phenol) a cis- diphosphate kinase: ndkA GMP AMP Probable integral sn-glycerol a purine cys L-homocysteine dihydro-8- hydroxyoctadec- a protein Rv1664 reductase: fabG2 androsta-1,4-diene-3,17-dione carboxyphthiodiolenone synthase] vaccenoyl-[acp] Rv1521 a (5Z)-tetracos-5-enoyl-[acp] membrane 3-phosphate ribonucleoside oxoguanine mismatch 11-enoyl-[acp] (S)-3-hydroxy-(5Z) Probable N-acetylmuramoyl- AIR phosphatidate phenolpthiocerol 1-acylglycerol- probable Probable 3-hydroxyacyl- Outer [+ 2 isozymes] -tetradecenoyl-CoA acyl-CoA L-alanine Probable purine dTTP adenine thioester cytidylyltransferase: 1,4-androstadiene- thioesterase II amidase: Rv3717 synthesis type-I 3-phosphate O- nucleoside cystathionine membrane α glycosylase dehydratase: Rv0472c a (3R)-3- cis-delta5-C24:1- cdsA 3,17-dione 9 - TesB1: tesB1 polyketide synthase acyltransferase: phosphorylase: beta- protein [acyl-carrier hydroxylase: ditrans,octacis- Rv2182c synthase: cbs MutY: mutY htdX Rv2060 hydroxyhexacosanoyl-[acp] Pps: ppsA ppsB deoD A OmpA: Rv0481c a peptidoglycan undecaprenyldiphospho- 1-palmitoyl-2- protein]:malonyl- a CDP- kshB kshA Probable ppsC ppsD ppsE ompA pentapeptide N-acetyl-(N- acyl-carrier protein cis-vaccenoyl α-D-ribose- L-cystathionine an apurinic site [+ 3 isozymes] 3-hydroxyacyl- [acyl-carrier protein] diacylglycerol acyl-CoA a C32-carboxyphthiodiolenone- a purine base adenine a (2E,11Z)- Carbohydrate Biosynthesis 9α-hydroxyandrosta- acetylglucosaminyl)muramate phosphatidate 1-phosphate within DNA thioester malonyltransferase: thioesterase [(phenol)carboxyphthiodiolenone octadeca-2,11- a peptide kasA 1,4-diene-3,17-dione Rv3736 dehydratase: htdX Probable CDP- II: tesB2 synthase] dienoyl-[acp] Rv2075c gluconeogenesis I superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis Cell Structure Biosynthesis diacylglycerol--glycerol- LpqZ GDP-mannose biosynthesis [+ 3 isozymes] UDP-α-D-glucose peptidoglycan maturation (meso-diaminopimelate containing) [+ 2 isozymes] 3-phosphate 3- (3E,5Z)- tetradecadienoate biosynthesis I phosphatidyltransferase: an NDP-α- 3-phospho- 1-palmitoyl- a palmitoyl-[(hydroxy) (S)-3- 3-oxo-4- a trans-hexacos-2-enoyl-[acp] a (7Z)-3-oxohexacos- + (S)-malate UDP-α-D- D-glucopyranose lipid II (meso pgsA2 3-hydroxy-9,10- D-glucose a purine 2’- hydroxydecanoyl- pregnene-20- D-glucopyranose IPP 7-enoyl-[acp] glu NAD D-glycerate a palmitoyl-[acp] sn-glycerol phthioceranic dIDP D-glucopyranose galactofuranose 6-phosphate 6-phosphate diaminopimelate containing) secoandrosta-1,3,5(10) 3-phosphate deoxyribonucleoside acid synthase] CoA carboxyl-CoA Rv2240c Rv2108 glucose-6- -triene-9,17-dione Probable glucosyl-3- Rv3090 [NAD] dependent 6-phosphate biosynthesis a trans-hexacos- Probable Probable NADH- 1-acylglycerol- C37- probable 3- 3-oxo-23,24- peptidoglycan cis-delta7-3- phosphoglycerate Probable purine Probable malate phosphoglucomutase: phosphate glucose-6- Probable 2-enoyl-[acp] dependent 3-phosphate O- phthioceranyl- bisnorchol-4- oxo-C26:1-[acp] PGP synthase nucleoside hydroxybutyryl- nucleoside pgmA UDP-α-D-glucose isomerase: pgi transglycosylase: Polymeric Compound Degradation glutamate synthase acyltransferase: oxidoreductase: mez phosphate isopentenyl- reductase: fas synthase: 3-hydroxy-9,10- phosphorylase: CoA CoA en-22-CoA 1- malate α-D-glucopyranose rodA reductase: fabG1 GpgS: gpgS diphosphate F6P isomerase: diphosphate pgsA3 mycobacterial sulfolipid biosynthesis seconandrost- (small subunit): gltD Rv2182c synthase: pks2 dehydrogenase: dehydrogenase: UDP-galactose 4- α deoD kinase: ndkA dehydrogenase: mdh 1-phosphate + 2-O-( -D- α a C37-phthioceranyl- epimerase: galE1 pgi delta- [+ 3 isozymes] 1,3,5(10)-triene- chitin degradation II (Vibrio) dipalmitoyl 2-deoxy- - fadB3 kstD Rv2875 Rv2871 peptidoglycan a cerotoyl-[acp] H NADH 2-oxoglutarate gln a nucleoside glucopyranosyl) acyl-carrier protein [(hydroxy)phthioceranic Rv3840 isomerase: idi 1-(3-sn- 9,17-dione 4- phosphatidate D-ribose 1- a purine base 3-oxo-23,24- [NAD] dependent [+ 3 isozymes] Probable glycosyltransferase: a (3R,7Z)-3-hydroxyhexacos- diphosphate -3-phospho- acid synthase] 3-oxodecanoyl- dITP UTP--glucose- phosphatidyl) monooxygenase: phosphate bisnorchol-1,4- malate UDP-α-D-galactose F6P ponA1 a palmitoyl-[acp] CoA 1-phosphate mannose-6- 7-enoyl-[acp] hsaA D-glycerate dien-22-yl-CoA cerotoyl-[acp] -sn-glycerol chitin oxidoreductase: mez phosphate DMAPP probable [NAD] uridylyltransferase: 3-phosphate a nascent peptidoglycan Synthase: fas dependent malate galU UDP- isomerase: 3,4-dihydroxy-9,10- Probable γ cis-delta7-3- Possible EsxN galactopyranose manA with (L-alanyl- -D-glutamyl- secoandrosta-1,3,5(10) 2503 Rv3856c Rv0297 oxidoreductase: mez glucosamine- β meso-2,6-diaminopimeloyl-D- hydroxyC26:1- chitinase: adenine 4-(β-D- 1-palmitoyl- 5’-deoxy-5’- a palmitoyl-[(hydroxy) D-glycero- -D- UDP-α-D-glucose mutase: glf cerotoyl-CoA -triene-9,17-dione (7,8-dihydropterin- -fructose-6- [acyl-carrier Rv1987 in 23S rRNA sn-glycerol a myristoyl-[acp] phthioceranic Ins(1)P manno-heptose D-mannopyranose alanyl-D-alanine) pentapeptide ribofuranosyl) fluoroadenosine IDP phosphate protein] 6-yl)methyl 1,7-bisphosphate oxaloacetate pyruvate UDP-Galf an L-1- palmitate aminobenzene- 3-phosphate acid synthase] 6-phosphate aminotransferase cerotoyl-CoA 3,4-dihydroxy- 23S rRNA diphosphate Probable purine inositol-phosphate dehydratase: 5’-phosphate 1-acylglycerol- C40- D-alpha,beta- α geranyl phosphatidyl- 9,10- a chitodextrin (adenine(2503)-C(2) nucleoside Probable -D- [isomerizing]: glmS probable carboxylase: hadA hadB dihydropteroate 3-phosphate O- phthioceranyl- phosphatase: cysQ D-heptose-1,7- Rv3653 Probable diphosphate probable sn-glycerol Rv0961 glucopyranose penicillin-binding accD5 palmitate secoandrosta- )-methyltransferase: synthase: folP2 phosphorylase: nucleoside Rv0980c phosphomannomutase: penicillin-binding acyltransferase: CoA biphosphate 1-phosphate protein: dacB1 adenylyltransferase: 1,3,5(10)-triene- rlmN 7,8-dihydropterin- deoD Probable inositol- diphosphate pmmA D-glucosamine protein: dacB1 Rv2182c synthase: pks2 phosphatase: E,Z-farnesyl [+ 3 isozymes] a (2E,7Z)-hexacosa- 9,17-dione 4,5- 2503 β monophosphatase: kinase: ndkA 6-phosphate a mature peptidoglycan with fadD23 6-ylmethyl-4-( - 1-palmitoyl- a C40-phthioceranyl- gmhB diphosphate [+ 4 isozymes] γ 2,7-dienoyl-[acp] a 2-methyladenine 5-fluoro-5- impA Alpha-D-glucose- [+ 3 isozymes] (L-alanyl- -D-glutamyl-meso- dioxygenase: 5’-deoxyadenosine met D-ribofuranosyl) acyl-carrier protein 2-myristoyl [(hydroxy)phthioceranic D-glycero-β-D- Probable synthase: 2-carboxy-cerotoyl-CoA in 23S rRNA deoxy-D-ribose adenine ITP phosphoenolpyruvate 1-phosphate 2,6-diaminopimeloyl-D-alanyl- mycocerosic acid hsaC a chitodextrin aminobenzene phosphatidate acid synthase] manno-heptose Rv1480 phosphomannomutase: phosphoglucosamine Rv1086 1-phosphate myo-inositol Rv0261c thymidylyltransferase: D-alanine) pentapeptide trans-delta2-cis- adenylyltransferase: 5’-phosphate 1-phosphate pmmB mutase: mrsA a nascent peptidoglycan a nascent peptidoglycan Rv3892c rmlA delta7-C26:2- fadD28 (1E,2Z)-3-hydroxy- Probable (2Z,6E)-farnesyl with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- α-D-mannose α [acp]:NADH+ 5,9,17-trioxo-4,5:9,10- Possible enolase Eno: eno -D-glucosamine diphosphate meso-2,6-diaminopimeloyl- diaminopimelate containing) α oxidoreductase: (palmitoyl) disecoandrosta-1 1-phosphate dTDP- -D-glucose 1-phosphate D-alanine) tetrapeptide chitinase: α inhA α α adenylate 1-cis-vaccenoyl- a 5-aminomethyl-2- D-glycero- -D- a methyl- Rv2219 , -trehalose a palmitoyl-[acp] (10),2-dien-4-oate Rv1987 a 10- an L-methionyl- Met quinoxaline-2- a cis- 34 propan-1-ol TatD 2-phospho-D-glycerate aryl-carrier protein sn-glycerol- thiouridine in tRNA MEP manno-heptose branched lipid mannose-1-phosphate mono-trans formyltetrahydrofolate [initiator tRNA ] carboxyl adenylate vaccenoyl-[acp] dTDP- glucosamine-1- long-chain fatty acid 3-phosphate 1,7-bisphosphate Rv0592 guanylyltransferase: -poly-cis- L,D-transpeptidase Probable tRNA (5- Probable 1- Probable NADP- methyl- glucose 4,6- phosphate N- trehalose 2- adenylyltransferase: N,N’- N,N’,N’’- Probable Probable 1-acylglycerol- D-alpha,beta- manB nonaprenyl-cis 4: Rv0192 a mature peptidoglycan a (7Z)-hexacos-7-enoyl-[acp] 2,3-bisphosphoglycerate- dehydratase acetyltransferase: sulfotransferase: 4,5-9,10-diseco- methionyl-tRNA acyl carrier methylaminomethyl- deoxy-D-xylulose dependent alcohol branched with D,D cross-links (meso- fadD23 diacetylchitobiose triacetylchitotriose 3-phosphate O- D-heptose-1,7- dependent -transferase: 2-thiouridylate)- 5-phosphate dehydrogenase lipid ω- RmlB: rmlB glmU Rv0295c 3-hydroxy-5,9,17- formyltransferase protein: acpA acyltransferase: biphosphate Rv1135c α Rv2361c Probable L,D- a nascent peptidoglycan with a nascent peptidoglycan a mature peptidoglycan diaminopimelate containing) Rv1401 phosphoglycerate GDP- -D-mannose a palmitoyl- trioxoandrosta- Fmt: fmt methyltransferase reductoisomerase: dxr AdhC: adhC hydroxylase: transpeptidase (L-alanyl-γ-D-glutamyl-meso- γ γ cis-delta7-C26:1- Rv2182c phosphatase: mutase subunit: gpmA glycogen biosynthesis III (from α-maltose 1-phosphate) [+ 2 isozymes] N-acetyl-α-D- with (L-alanyl- -D-glutamyl- with (L-alanyl- -D-glutamyl- 2-O-sulfo- [(hydroxy) an N-formyl- [+ 2 isozymes] TrmU: trmU 1-deoxy-D- cyp124 mono-trans,octa- palmitoyl-CoA 1(10),2- 1,2-dicis- gmhB glucosamine LdtB: ldtB 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- meso-2,6-diaminopimeloyl- [acyl-carrier α,α-trehalose a quinoxaline-2- [+ 5 isozymes] phthioceranic diene-4-oate L-methionyl- met a tetrahydrofolate acyl-carrier protein vaccenoyl- xylulose 5- α ω CFP-2 dTDP-4-dehydro- cis-decaprenyl protein]:malonyl- a 5-methylaminomethyl- D-glycero- -D- an -hydroxy- 1-phosphate glycine) tetrapeptide D-alanine) tetrapeptide N-acetyl-D- [initiator tRNA ] AMP carboxyl-[aryl- 34 phosphate acid synthase] hydrolase: hsaD phosphatidate 1-propanal methyl- 3-phospho-D-glycerate 6-deoxy-α-D- diphosphate [acyl-carrier protein] glucosamine carrier protein] 2-thiouridine in tRNA manno-heptose D-glucopyranose 6-phosphate ADP-α-D-glucose glucopyranose a nascent peptidoglycan malonyltransferase: 2-O-sulfo trehalose C37- 1-phosphate branched lipid Rv0042c UDP-N- decaprenyl- IniB with L,D cross links (meso- kasA palmitoyltransferase: hydroxyphthioceranyl- Probable acetylglucosamine diphosphatase: PRPP biosynthesis dTDP-4- diaminopimelate containing) a mature peptidoglycan with papA2 3-[(3aS,4S,7aS)-7a-methyl- phosphoglycerate pyrophosphorylase: CoA synthase: pks2 (2Z,4Z)-2-hydroxyhexa- Rv2136c (L-alanyl-γ-D-glutamyl-meso- 1,5-dioxo-octahydro-1H dehydrorhamnose a mature peptidoglycan [+ 2 isozymes] 2,4-dienoate 1-myristoyl- Rv0172 kinase Pgk: pgk alpha, alpha-trehalose- glmU Aromatic Compound Biosynthesis a C37- 5-methoxybenzimidazole a very-long- S-(hydroxymethyl) a [protein]-L- 3,5-epimerase: rmlC trans,octacis 2,6-diaminopimelate) tripeptide γ -inden-4-yl]propanoate sn-glycerol 3-oxopropanoate sn-glycerol phosphate synthase D-ribose 5- with (L-alanyl- -D-glutamyl- hydroxyphthioceranyl- adenosylcobinamide-GDP chain fatty acid a myristoyl-[acp] bacillithiol sn-glycerol methionine 2’-palmitoyl- 2-hydroxyhexa- ribotide phosphate 3-phosphate 3-phosphate Rv3732 phosphate UDP-N-acetyl- -decaprenyl meso-2,6-diaminopimeloyl- a (9Z)-3-oxooctacos- 3-phosphate Rv1825 [ADP-forming]: otsA dTDP-4-dehydro- [(hydroxy)phthioceranic acyl-CoA 13-DPG α phosphate 9-enoyl-[acp] 2-O-sulfo- 2,4-dienoate probable cobalamin acyl-CoA Probable Probable glycerol- mycothiol- peptide Probable ribose- β -D-glucosamine glycine) tetrapeptide salicylate α α acid synthase] synthetase: Probable glycerol- 1-acylglycerol- -L-rhamnose a mature peptidoglycan 4-hydroxybenzoate , -trehalose hydratase: hsaE 5’-phosphate synthetase: methylmalonate- 3-phosphate dependent methionine phosphate biosynthesis I fadD32 3-phosphate 3-phosphate O- with L,D cross-links (meso- biosynthesis synthase: cobS fadD32 semialdehyde acyltransferase: formaldehyde sulfoxide pyrophosphokinase: cis-delta9-3- acyltransferase: acyltransferase: LprM glyceraldehyde α α decaprenol-monophosphate-N- diaminopimelate containing) (S)-4-hydroxy- phosphoglucomutase: pgmA , -trehalose 6-phosphate dTDP-6- II (bacteria) oxo-C28:1-[acp] Coα-[α-(5- plsB2 dehydrogenase: plsB2 dehydrogenase Rv2182c reductase: 3-phosphate prsA acetylglucosaminyltransferase: rfe chorismate 2’-palmitoyl-2-O-sulfo- 2-oxohexanoate [+ 21 isozymes] deoxy- reductase: fabG1 3-[(3aS,4S,7aS GMP β 1-myristoyl- mmsA 1-C16:0-α,ω- subunit: mscR 1-myristoyl-2- msrA Rv1939 dehydrogenase: gap trehalose (hydroxy) methoxybenzimidazolyl)]-Co - Rv3669 triosephosphate PRPP L-lyxo-4- isochorismate chorismate )-7a-methyl-1,5- a very-long-chain acyl-carrier protein sn-glycerol dicarboxyl-2- palmitoleoyl- trehalose 6-phosphate phthioceranyltransferase: adenosylcobamide 5’-phosphate AMP diphosphate a protein-L- isomerase: tpi hexulose [+ 3 isozymes] dioxo-octahydro- fatty acyl-CoA NADH CO 2 acetyl-CoA lysophosphatidate S-formylbacillithiol phosphatase: otsB2 N-acetyl-α-D- synthase: mbtI chorismate 3-phosphate sn-glycerol methionine- DHAP D-glyceraldehyde 3-phosphate reductase: papA1 4-hydroxy-2- 1H-inden-4- glucosaminyl- lyase: 3-phosphate (S)-S-oxide rmlD Probable a cis-delta9-3- oxohexanoate yl]propanoyl:CoA PepA α α diphospho- Rv2949c , -trehalose isochorismate hydroxyC28:1-[acp] aldolase: hsaF ligase: fadD3 Rv2328 trans,octacis- Rv0007 dTDP-β-L- synthase: entC 4-hydroxybenzoate SL 1278 decaprenol α ω rhamnose cis-delta9-3- 3-[(3aS,4S,7aS)-7a-methyl- , -9Z- (S)-4-hydroxy- 3-oxo-23,24- a [protein]-L- Probable fructose- trehalose synthase: treS isochorismate 5-hydroxybenzimidazole sn-glycerol L-gulono- an oxidized c- 1-(18-hydroxyoleoyl)- α 1-propanal pyruvate 1,5-dioxo-octahydro-1H- adenosylcobinamide-GDP octadecenedioate a palmitoyl-[acp] 2-oxopentanoate bisnorchol- methionine bisphosphate α α UDP- -D-glucuronate hydroxyC28:1- SL1278 ribotide phosphate 3-phosphate 1,4-lactone type cytochrome sn-glycrol 3-phosphate -D-glucopyranose 1-phosphate ADP- -D-glucose inden-4-yl]propanoyl-CoA 4-en-22-oate aldolase Fba: fba biosynthesis (from [acyl-carrier hydroxyphthioceranyltransferase: probable cobalamin acyl-CoA Rv2223c α UDP-α-D-glucose isochorismate Probable glycerol- L-gulono- 1-acylglycerol- Probable 4- 3-oxo-23,24- peptide Rv3435c -maltose UDP-glucose) decaprenyl-N-acetyl- protein] Rv3822 propanal 5’-phosphate synthetase: Rv2237 α pyruvate 3-phosphate 1,4-lactone 3-phosphate O- hydroxy-2- bisnorchol-4- methionine -D-glucosaminyl- dehydratase: dehydrogenase: 3-[(3aS,4S,7aS synthase: cobS fadD32 α-maltose-1-phosphate UDP-α-D-glucose lyase: mbtI acyltransferase: dehydrogenase: acyltransferase: oxovalerate en-22-oate 9α- sulfoxide maltokinase: mak pyrophosphate:dTDP- hadA hadB sulfolipid-2 hsaG )-7a-methyl-1,5- synthase: glgA α UDP- Coα-[α-(5- [+ 21 isozymes] plsB2 Rv1771 Rv2182c aldolase: hydroxylase: reductase: β Probable UDP-glucose -L-rhamnose dioxo-octahydro- -D-fructose 1,6-bisphosphate galactose 4- salicylate GMP hydroxybenzimidazolyl)]-Coβ- ω 1-palmitoyl- 1-[18-hydroxyoeoyl]-2- mhpE kshB kshA msrB 6-dehydrogenase: udgA rhamnosyltransferase: 1H-inden-4- -carboxy- a reduced c- L-dehydro- epimerase: a trans-delta2-cis- propanoyl-CoA adenosylcobamide 5’-phosphate acyl-carrier protein sn-glycerol [18-hydroxy-lioleoyl]-sn 3-one-9-hydroxy- a protein-L- Rv3654c Rv0900 UDP-α-D-glucuronate wbbL1 yl]propanoyl-CoA AMP diphosphate (9Z)-octadec- type cytochrome ascorbate ThiC galE1 delta9-C28:2-[acp] 3-phosphate -glycerol 3-phosphate pyruvate acetaldehyde 23,24-bisnorchol- methionine- fructose-1,6- α-maltose 1-phosphate reductase: ipdF 9-enoyl-CoA 4-en-22-oate (R)-S-oxide bisphosphatase: [+ 3 isozymes] gpm2 trans-delta2-cis- 5-hydroxy-3-[(3aS,4S α UDP-α-D- polyacyltrehalose biosynthesis UDP-N-acetyl-D- starch synthase (maltosyl- -L- delta9-C28:2- ,5R,7aS)-7a-methyl-1,5- galactose Rv3843c [+ 2 isozymes] transferring): glgE rhamnopyranosyl- [acp]:NADH+ dioxo-octahydro-1H- Rv0439c galactosamine a [DNA]-3’- a 5’-phospho- + (S)-propane- 1-palmitoyl- Rv1450c (1->3)-N-acetyl- triacylglycerol 5-methylbenzimidazole sn-glycerol an oxidized 1-cis-vaccenoyl-sn- biosynthesis I oxidoreductase: a holo inden-4-yl]propanoyl-CoA adenosylcobinamide-GDP NAD sn-glycerol a D-amino acid F6P α UDP- degradation ribotide phosphate hydroxyl [DNA] a stearoyl-[acp] CO glycerol-3-phosphate 1,2-diol a 1,4-α-D-glucan -D-glucosaminyl- inhA mycolipanoic 3-phosphate cytochrome b 561 UDP-N-acetyl- galactopyranose 3-phosphate diphospho- acid synthase probable cobalamin DNA ligase 1-acylglycerol- Probable NADP- α-D-glucosamine mutase: glf 5-hydroxy-3- Probable glycerol- carbon monoxide 1-acylglycerol- Probable glucose-6-phosphate trans,octacis- 5’-phosphate [NAD 3-phosphate O- dependent UDP-N- 1,4-alpha-glucan a triglyceride [(3aS,4S,5R,7aS 3-phosphate dehydrogenase: 3-phosphate O- D-amino isomerase: pgi decaprenol a cis-delta9-C28:1-[acp] mycolipanoate synthase: cobS dependent]: acyltransferase: alcohol Rv2047c acetylgalactosamine branching enzyme: glgB UDP-Galf )-7a-methyl-1,5- acyltransferase: Rv0373c acyltransferase: UmaA triacylglycerol ligA acid Rv1810 synthase: pks3 dioxo-octahydro- Coα-[α-(5-methylbenzimidazolyl) plsB2 Rv0375c Rv0374c Rv2182c dehydrogenase Rv2182c 4-epimerase: galE1 lipase: lipL oxidase UDP-N-acetyl-α- 1H-inden-4- GMP ]-Coβ-adenosylcobamide 1-stearoyl- 1-cis-vaccenoyl- AdhC: adhC 1-palmitoyl-2- D-glucopyranose 6-phosphate a GlgE-glycogen a mycolipanoyl- a reduced Aao: aao D-galactosamine cis-delta9-C28:1- 2-palmitoleoyl-sn- palmitoleoyl- triacylglycerol yl]propanoyl-CoA 5’-phosphate NMN AMP [DNA] acyl-carrier protein sn-glycerol rhamnosyl- [acyl-carrier [mycolipanoic cytochrome b 561 a 2-oxo lipase: lipD dehydrogenase: 3-phosphate glycerol-3-phosphate (S)-lactaldehyde sn-glycerol acid synthase] Rv0280 N-acetyl- protein]:malonyl- fadE30 3-phosphate carboxylate TcrY glucosaminyl- [acyl-carrier protein] biotin-carboxyl carrier triacylglycerol Rv2126c decaprenyl malonyltransferase: lipase: lipN protein assembly (2E)-3-[(3aS,4S,5R,7aS) diphosphate kasA -5-hydroxy-7a-methyl-1- galactofuranosyl triacylglycerol (5Z,8Z,11Z,14Z,17Z) an N-acylated 2E)-tetradec- a [lipoyl-carrier a 1-acyl-sn a [biotin carboxyl- 16-hydroxypalmitate 6 lipase: lipU oxo-octahydro-1H-inden- S-methyl-L- -glycerol 3- D-lysine Rv2843 transferase: glfT1 [+ 2 isozymes] a mycolipanoate carrier protein]-L-lysine -icosapentaenoyl-CoA L-homocysteine aliphatic-L- 2-enoyl-CoA protein] N -[(R) Rv3778c 4-yl]prop-2-enoyl-CoA methionine phosphate acyl-CoA Probable acyl- amino acid enoyl-CoA -dihydrolipoyl]- PE-PGRS Possible N-acyl- 1-acylglycerol- Rv1386 a cis-delta11-3- biotin--[acetyl- synthetase: fadD32 CoA thioesterase Probable hydratase: L-lysine Probable family protein, L-amino acid 3-phosphate O- oxo-C30:1-[acp] α,α-trehalose CoA-carboxylase] II TesB1: tesB1 homocysteine S- echA2 dihydrolipoamide D-amino triacylglycerol [+ 21 isozymes] methyltransferase: amidohydrolase: acyltransferase: Secondary Metabolite Biosynthesis β-D-galactofuranosyl- synthetase: birA dehydrogenase: acid α lipase: lipY mmuM amiA1 [+ 18 isozymes] Rv2182c Rv2128 (1->4)- -L- cis-delta11-3- 3-[(3aS,4S,5R,7aS)-5- Probable acyl-CoA lpdC oxidase CcsA long-chain-acyl- a mycolipanoyl- AMP diphosphate 16-hydroxypalmitoyl-CoA (S)-3- a 1-acyl-2- rhamnopyranosyl- oxo-C30:1-[acp] a [biotin carboxyl-carrier6 a 1,2-diglyceride thioesterase II: tesB2 an aliphatic a [lipoyl-carrier6 Aao: aao CoA--trehalose CoA hydroxy-7a-methyl-1-oxo- met a carboxylate hydroxytetradecanoyl- palmitoyl-sn ergothioneine biosynthesis I (bacteria) (1->3)-N-acetyl- reductase: fabG1 protein]-N -biotinyl-L-lysine (5Z,8Z,11Z,14Z,17Z) L-amino acid protein]-N - Rv1728c mycocyclosin acyltransferase: octahydro-1H-inden-4-yl]- coenzyme A CoA -glycerol 3- 6-amino-2- α-D-glucosaminyl- -icosapentaenoate lipoyl-L-lysine biosynthesis [+ 3 isozymes] papA3 3-hydroxypropanoyl-CoA phosphate oxohexanoate diphospho- DipZ probable 3- Rv0544c cys trans,octacis- a cis-delta11-3- a 2-(long- an L-tyrosyl- decaprenol hydroxybutyryl- Tyr hydroxyC30:1-[acp] chain-fatty a mycolipenoyl- a [biotin carboxyl- [tRNA ] a 2-acylglycerol CoA acyl)-trehalose CoA carrier-protein6 dimer]- a 2-acyl-sn a peptide with a long-chain fatty d-biotin d EsxF galactofuranosyl- dehydrogenase: 18-hydroxystearate a purine an acyl-[acyl- S-(hercyn-2-yl)-L- a O- Putative cyclo(L- peptidoglycan biosynthesis III (mycobacteria) N -biotinyl-L-lysine -glycerol 3- an N-terminal acyl-[mycocerosic -sulfoxide rhamnosyl-N- cis-delta11-3- fadB3 ribonucleoside adenosylcobinamide carrier protein] cysteine S-oxide sialoglycoprotein glutamate- tyrosyl-L- acyl-CoA phosphate L-alanine acid synthase] UvrC acetyl-glucosaminyl- hydroxyC30:1- 5’-triphosphate Probable Probable Probable PstS2 -cysteine tyrosyl) mycolipenoyl-CoA--2- acetyl/propionyl- 3-[(3aS,4S,5R,7aS)-5- synthetase: fadD32 1-acylglycerol- Probable O- decaprenyl UDP-N-acetyl- [acyl-carrier hercynylcysteine aminopeptidase mycocerosate biotin ligase 2: his synthase: long-chain-acyl-trehalose coa carboxylase biotin hydroxy-7a-methyl-1-oxo- adenosylcobinamide 3-phosphate O- sialoglycoprotein diphosphate:UDP- α-D-glucosamine protein] [+ 21 isozymes] PepC: pepC synthase: mas sulfoxide Rv0433 Rv2275 mycolipenoyltransferase: alpha chain: kinase: cobU acyltransferase: sulfoxide carboxylase: a 1-monoglyceride octahydro-1H-inden-4- endopeptidase: gcp D-galacto-1,4- dehydratase: Rv2182c lyase: egtE reductase: Rv3514 cyclo-(L-tyrosyl- UDP-N- papA3 accD6 accA3 accA1 yl]-3-oxopropanoyl-CoA a purine adenosyl- [+ 2 isozymes] histidine furanose UDP- hadA hadB AMP diphosphate 18-hydroxystearoyl-CoA a 1,2-diacyl- a tetramethylated bisC Rv1796 Glutamate- L-tyrosyl) acetylglucosamine ribonucleoside cobinamide methyltransferase: galactofuranosyl- [+ 4 isozymes] monoacylglycerol acyl-carrier protein sn-glycerol pyruvate ergothioneine a peptide a peptide ala mycocerosyl- enolpyruvyl 5’-diphosphate phosphate EsxA -cysteine (1->5)- 3-phosphate [mycocerosic biotin egtD mycocyclosin D-ribose 5- a trans-delta2-cis- a 2-(long-chain a [carboxyl-carrier lipase: Rv0183 ligase: gshA transferase: glfT1 transferase: murA 6 probable beta- acid synthase] synthase: phosphate delta11-C30:2-[acp] fatty acyl)-3- protein dimer]-N - ketoacyl CoA γ cyp121 α mycolipenoyl- carboxybiotinyl-L-lysine glycerol EsxK -L-glutamyl- hercynine β-D-galactofuranosyl- UDP-N-acetyl- - thiolase: fadA3 Probable ribose- trehalose Rv3277 L-cysteine (1->5)-β-D- D-glucosamine- trans-delta2-cis- 1920 phosphate a peptidoglycan dimer (meso TatC mycocyclosin galactofuranosyl- enolpyruvate delta11-C30:2- mycolipenyl-CoA- probable a cytidine long chain 3S-(4- pyrophosphokinase: (2E)-hexadecenoate -diaminopimelate containing) an alkylated DNA myo-inositol (1->4)-α-L- [acp]:NADH+ -diacyltrehalose acetyl-CoA a mercapturate in 23S rRNA L-homocysteine polyphosphate hydroxyphenyl) prsA Hercynine UDP-N- acyltransferase: acyl-CoA probable -3-hydroxy- biosynthesis rhamnopyranosyl- oxidoreductase: mycolipenyltransferase: possible 3- 23S rRNA Possible N-acyl- 1920 probable inorganic oxygenase: (1->3)-N-acetyl- acetylenolpyruvylglucosamine fadA2 synthetase: fadD32 penicillin-binding propanoyl-CoA Rv3354 inhA Rv1184c methyladenine (cytidine -2’-O)- polyphosphate/ Rv2206 egtB tuberculosinol α reductase: murB protein: dacB1 L-amino acid homocysteine S- steroid D-glucopyranose PRPP -D-glucosaminyl- DNA methyltransferase: biosynthesis a 2-(long-chain [+ 19 isozymes] amidohydrolase: methyltransferase: ATP-NAD RplJ 6-phosphate diphospho- enoyl-CoA ala UDP-N-acetyl- fatty acyl)-2’,3,4’,6- glycosylase: mpg tlyA kinase: ppnK a cis-delta11-C30:1-[acp] 3-[(3aS,4S,5R,7aS)- [+ 4 isozymes] amiA1 mmuM hydratase: γ inositol-1- α trans,octacis- α -L-glutamyl-S- 5-phospho- -D-ribose-1- -D-muramate tetramycolipenoyl- acetyl-CoA AMP diphosphate (2E)-hexadecenoyl-CoA a peptidoglycan with a DNA containing a 2’-O- 1920 phosphate decaprenol 5-hydroxy-7a-methyl- an alkylated an L-cysteine- echA9 (hercyn-2-yl)-L- GGPP diphosphate:decaprenyl- glu trehalose D-ala D,D cross-links (meso- an apurinic/ acetate methylcytidine met [+ 2 isozymes] 1-oxo-octahydro-1H- nucleobase (E)-4- cysteine S-oxide synthase: ino1 galactofuran:UDP- apyrimidinic site S-conjugate in 23S rRNA long chain Rv1500 phosphate 5- diaminopimelate containing) coumaroyl-CoA Rv0040c halimadienyl- D-galacto-1,4- UDP-N- cis-delta11-C30:1- indene-4-carboxyl-CoA polyphosphate Ins(3)P phosphoribosyltransferase: ubiA dimycocerosyl Rv3595c Gamma-glutamyl- diphosphate furanose UDP- glutamate acetylmuramate- [acyl-carrier synthase: racemase: protein]:malonyl- phthiocerol biosynthesis hercynylcysteine trans,octacis- galactofuranosyl- -L-alanine 3-[(3aS,4S,5R sulfoxide Probable inositol- Rv3377c (1->6)- murI ligase: murC [acyl-carrier protein] ,7aS)-5-hydroxy- decaprenylphospho- a long-chain 1409 hydrolase: egtC monophosphatase: tuberculosinyl transferase: glfT2 malonyltransferase: 7a-methyl-1- a cytidine β-D-ribofuranose phospholipases 18-hydroxyoleate a sulfurated a glycogen maltohexaose a ribonucleoside Rv3343c kasA fatty acid hydrogen cyanide phosphoenol Rv0755c impA diphosphate oxo-octahydro- in 16S rRNA ATP an mRNA 5-phosphate [β-D- D-glt UDP-N-acetyl-α-D- [sulfur carrier] diphosphate dGDP RpsG Aminoacyl-tRNA Charging 1H-indene-4- acyl-CoA pyruvate S-(hercyn-2-yl)-L- mycocerosic acid Probable Probable 16S rRNA galactofuranosyl- muramoyl-L-alanine [+ 2 isozymes] a 1,2-diacyl- Probable thiosulfate 1409 ribonucleoside- cysteine S-oxide Inositol-1- tuberculosinol decaprenylphosphoryl- carboxyl-CoA synthetase: fadD32 glycogen glycogen Probable (1->5)-β-D- adenylyltransferase: sn-glycerol sulfurtransferase: (cytidine -2’-O)- diphosphate Probable monophosphatase synthase: 5-phosphoribose a phosphatidylcholine dehydrogenase: phosphorylase phosphorylase tRNA charging fadD28 [+ 21 isozymes] cysA2 methyltransferase: reductase: nrdE pyruvate Rv3378c galactofuranosyl- a cis-delta13-3- 3-phosphate poly(A) Probable SuhB: suhB phosphatase: Rv3807c UDP-N- ipdC GlgP: glgP GlgP: glgP tlyA kinase LppY (1->6)] 14 -β-D- L-asparagine oxo-C32:1-[acp] polymerase: hercynylcysteine acetylmuramoylalanine-- a long-chain [+ 3 isozymes] α α [+ 4 isozymes] PykA: pykA Rv2525c trans,octacis- galactofuranosyl- Probable biosynthesis III AMP diphosphate 18-hydroxyoleoyl-CoA -D- -D- a 2’-O- 1409 a 2’- pcnA MtrB sulfoxide tuberculosinol D-glutamate ligase: murD fatty-acyl (5R,7aS)-5-hydroxy- an unsulfurated α myo-inositol decaprenylphospho- (1->5)-β-D- arginyl-tRNA (tRNA-dependent) thiocyanate glucopyranose an -limit dextrin glucopyranose maltopentaose methylcytidine deoxyribonucleoside arg cis-delta13-3- adenylate ester a 1-acyl-sn 7a-methyl-1-oxo- [sulfur carrier] dGTP pyruvate an mRNA lyase: egtE β-D-ribofuranose galactofuranosyl- 1-phosphate 1-phosphate in 16S rRNA synthetase: oxo-C32:1-[acp] -glycero-3- 3,5,6,7-tetrahydro-2H- 5’-diphosphate (1->4)--L- UDP-N-acetyl- argS asp reductase: fabG1 fatty-acid- phosphocholine indene-4-carboxyl-CoA decaprenylphospho- an L-arginyl- Rv0090 2-(hydroxysulfanyl) rhamnopyranosyl- α Arg AMP β-D-ribofuranose 2- meso-diaminopimelate -D-muramoyl-L- a phosphatidylcholine hercynine (1->3)-N-acetyl- [tRNA ] aspartyl- [+ 3 isozymes] RplN EsxI dehydrogenase: dprE1 alanyl-D-glutamate Arg Asn ligase: α-D-glucosaminyl- tRNA 5-hydroxy-7a- 37 a tRNA fadD28 a fatty acid a [lysine-biosynthesis- a plant soluble a cis-delta13-3- 1-stearoyl- a guanine (S)-1-pyrroline- a 1,4-α-D-glucan trans,octacis- diphospho- synthetase: methyl-1-oxo- 7-hydroxylaurate heteroglycan hydroxyC32:1-[acp] an oleoyl-[acp] sn-glycerol protein LysW]-C-terminal- in tRNA 5-carboxylate phosphoenol decaprenylphospho- trans,octacis- aspS a long-chain fatty 3,5,6,7-tetrahydro- γ dADP UDP-N- acyl-CoA 3-phosphate -(L-ornithyl)-L-glutamate Probable pyruvate Rv1591 β-D-erythro- decaprenol an L-aspartyl- acyl-[mycocerosic 2H-indene-4- probable tRNA Probable pyrroline- 1,4-alpha- acetylmuramoyl- Asn 1-acylglycerol- Probable [tRNA ] acid synthase] carboxyl-CoA synthetase: fadD32 glycogen (guanine-N1)- 5-carboxylate Probable glucan pentofuranosid-2-ulose cis-delta13-3- 3-phosphate O- acetylornithine Rv2560 L-alanyl-D- a 2-acyl-sn dehydrogenase: phosphorylase methyltransferase: dehydrogenase pyruvate branching LpqU ergothioneine hydroxyC32:1- [+ 21 isozymes] acyltransferase: aminotransferase glutamate--2,6- Cysteinyl- mycocerosate a phosphatidylcholine -glycero-3- ipdF GlgP: glgP trmD RocA: rocA kinase enzyme: decaprenyl- (Galf) -Rha-GlcNAc-P-P- probable glutamyl- [acyl-carrier Rv2182c ArgD: argD 1 30 D-ala diaminopimelate tRNA synthase: mas phosphoryl-2- cys tRNA(GLN) protein] phosphocholine a [lysine-biosynthesis-protein α-D- an N - PykA: pykA glgB C 50 :decaprenyl-phosphoryl- ligase: murE AMP diphosphate 7-hydroxylauroyl-CoA 1-stearoyl-2- 37 Rv0531 synthetase γ a plant soluble keto-β-D-erythro β-D-arabinofuranose amidotransferase: dehydratase: (5R,7aS)-7a-methyl-1,5- acyl-carrier protein oleoyl-sn-glycerol LysW]-C-terminal- -(L-glutamate glucopyranose methylguanine glu 1: cysS1 a mycocerosyl- heteroglycan dATP pyruvate starch -pentofuranose arabinofuranosyltransferase: aftA D-alanine- an L-cysteinyl- gatB gatA gatC hadA hadB dioxo-3,5,6,7-tetrahydro- 3-phosphate 5-semialdehyde-2-yl)-L-glutamate 1-phosphate in tRNA Rv3672c Cys [mycocerosic reductase: dprE2 -D-alanine [tRNA ] a phthiocerol membrane- 2H-indene-4-carboxyl-CoA Rv1352 mycobacterial UDP-N-acetyl-α-D- Cys acid synthase] ergothioneine ligase: ddlA an L-asparaginyl- associated arabinogalactan muramoyl-L-alanyl- a tRNA Asn a trans-delta2-cis- (thione form) trans,octacis- [tRNA ] phospholipase (5R,7aS)-7a- PrrA primed with γ-D-glutamyl-meso- delta13-C32:2-[acp] decaprenylphospho- C: plcB methyl-1,5- 1402 β arabinofuran D-alanyl-D-alanine 2,6-diaminopimelate phthiocerol α a cytidine α -D-arabinofuranose a cis- sn-glycerol a 1,4- -D-glucan sn-glycerol 1-hexanol a 1,4- -D-glucan Rv0029 dimycocerosyl dioxo-3,5,6,7- (2E,6E)-farnesyl diphosphate in 16S rRNA trans-delta2-cis- [+ 3 isozymes] dGTP vaccenoyl-[acp] 3-phosphate 3-phosphate transferase: a 1,2-diacyl- tetrahydro- Rv2431c delta13-C32:2- phosphatidylinositol a phosphatidylcholine Probable Ribosomal RNA Probable NADP- 1,4-alpha- α sn-glycerol 2H-indene-4- Probable glycerol- (2E,6E)-farnesyl Probable glycerol- arabinogalactan (1-->5) papA5 Probable deoxyguanosine glycogen glucan UDP-N- [acp]:NADH+ biosynthesis I (bacteria) carboxyl-CoA diphosphate ω- small subunit 3-phosphate dependent alcohol Rho arabinofuranosyltransferase: gln gln triphosphate 3-phosphate phosphorylase acetylmuramoyl- oxidoreductase: hydroxylase: methyltransferase acyltransferase: dehydrogenase branching glutaminyl-tRNA hydrolase: triphosphohydrolase: dgt acyltransferase: embA inhA D-glucopyranose GlgP: glgP H: rsmH AdhC: adhC enzyme: tripeptide--D- biosynthesis via a dimycocerosyl a 1-phosphatidyl- echA20 plsB2 cyp124 4 plsB2 Rv2625c an L-glutaminyl-Gln 6-phosphate a 1,2-diacyl- α glgB alanyl-D-alanine transamidation phthiocerol 1D-myo-inositol triphosphate -D- (2E,6E,10E)-12-hydroxy-3,7,11- an N - 1402 1-oleoyl-sn arabinogalactan α(1-->5) [tRNA ] 2’-deoxyguanosine 1-cis-vaccenoyl- ligase: murF Gln inositol-1- sn-glycerol glucopyranose a 1,4-α-D-glucan trimethyldodeca-2,6,10-trien-1- methylcytidine -glycerol 3- [+ 5 isozymes] Rv3511 arabinofuranosyltransferase: 4,5-bisphosphate (3R)-2-(2-carboxyethyl)- acyl-carrier protein sn-glycerol- a tRNA a cis-delta13-C32:1-[acp] phosphate 1-phosphate in 16S rRNA a glycogen 3-methyl-6-oxocyclohex- 3-phosphate yl phosphonatooxyphosphonate phosphate 1-hexanal Rv3519 embB glu synthase: ino1 1-ene-1-carboxyl-CoA α Rv0076c UDP-N-acetyl- -D- Ins(3)P cis-delta13-C32:1- mycobacterial muramoyl-L-alanyl- γ [acyl-carrier phosphatidylethanolamine (3R)-2-(2- a linear malto- arabinogalactan -D-glutamyl-meso- an L-glutamyl- 1-stearoyl- a maltodextrin long chain (2E)-dec-2- α-amylose Rv3494c Gln protein]:malonyl- biosynthesis I carboxyethyl) pyruvate an acyl-[acyl- butan-1-ol 2,6-diaminopimeloyl- phosphatidylinositol sn-glycerol oligosaccharide enoyl-CoA Rv3894c containing linear Glutamyl- [tRNA ] carrier protein] polyphosphate D-alanyl-D-alanine [acyl-carrier protein] phosphate -3-methyl-6- arabinofuran tRNA Probable pyruvate, 3-phosphate Probable Probable Exopolyphosphatase enoyl-CoA glu malonyltransferase: synthase: pgsA1 oxocyclohex-1- Probable NADP- 1,4-alpha- synthetase: a CDP-diacylglycerol 1-acylglycerol- glycogen glycogen hydratase: Rv3767c probable glutamyl- kasA ene-1-carboxyl- phosphate dikinase 2: ppx2 dependent alcohol glucan α phospho-N- gltS 3-phosphate O- arabinogalactan (1-->3) tRNA(GLN) a 1-phosphatidyl- PpdK: ppdK phosphorylase phosphorylase echA2 dehydrogenase branching an L-glutamyl- Probable CDP- CoA hydrolase: acetylmuramoyl- Glu 1D-myo-inositol acyltransferase: GlgP: glgP GlgP: glgP Exopolyphosphatase arabinofuranosyltransferase: aftC amidotransferase: Rv3552 Rv3551 AdhC: adhC enzyme: Rv3103c pentapeptide- [tRNA ] [+ 2 isozymes] diacylglycerol--serine O- Rv2182c 1: ppx1 [+ 18 isozymes] Rv3910 glu 3-phosphate + glgB gatB gatA gatC phosphatidyltransferase: AMP a 1-stearoyl 2- α-D- α-D- (S)-3- transferase: murX a tRNA diphosphate phosphoenolpyruvate H a linear malto- long chain mycobacterial a cis-delta15-3- glucopyranose [+ 5 isozymes] phosphatidylinositol- pssA 9-carboxy-6-methyl-3,7- acyl-carrier protein acyl-sn-glycerol glucopyranose a maltodextrin hydroxydecanoyl- Rv1234 arabinogalactan an L-glutaminyl- oligosaccharide polyphosphate amylopectin decaprenyl-diphospho- Gln oxo-C34:1-[acp] a 3-sn-phosphatidyl- 3-phosphate 1-phosphate 1-phosphate CoA butan-1-al containing α(1- 3-phosphate 3- dioxononanoyl-CoA N-acetylmuramoyl- [tRNA ] L-serine >3) arabinofuran phosphatase: sapM pentapeptide cis-delta15-3- Rv1980c Rv1733c linkages oxo-C34:1-[acp] a 1-phosphatidyl- Possible 9-carboxy-5- arabinogalactan Isoleucyl- reductase: fabG1 1D-myo-inositol phosphatidylserine 2-amino-6-[1-hydroxyethyl]- a [lysine-biosynthesis- a CDP- (12Z,15Z)-9,10- 1-cis-vaccenoyl- UDP-N- methyl-4,8- 1-myristoyl- Rv0174 α tRNA decarboxylase: psd protein LysW]-C-terminal- sn-glycerol- phytol (1-->3) ile 7-methyl-7,8-dihydropterin a myristoyl-[acp] sn-glycerol diacylglycerol epoxyoctadeca- an arachidoyl-[acp] acetylglucosamine- synthetase [+ 3 isozymes] dioxononanoyl- γ arabinofuranosyl 3-phosphate -(L-glutamyl)-L-glutamate 12,15-dienoate 3-phosphate -N-acetylmuramyl- IleS: ileS an L-1- CoA thiolase: Probable CDP- Probable NADP- transferase: embA 1-acylglycerol- Possible epoxide 1-acylglycerol- arachidoyl- Dfp (pentapeptide) an L-isoleucyl- a cis-delta15-3- phosphatidylethanolamine fadA6 2-amino-4-hydroxy-6- Probable diacylglycerol dependent alcohol Rv3367 Ile 3-phosphate O- hydrolase: ephF 3-phosphate O- [acp] pyrophosphoryl- [tRNA ] hydroxyC34:1-[acp] hydroxymethyldihydropteridinepyrophosphokinase: folK acetylglutamate pyrophosphatase: dehydrogenase arabinogalactan α(1-->3) Ile acyltransferase: acyltransferase: synthase: decaprenol N- a tRNA [+ 2 isozymes] kinase ArgB: argB cdh [+ 6 isozymes] AdhC: adhC HtpX Rv2182c Rv2182c fas arabinofuranosyltransferase: acetylglucosamine [1-(2-amino-7-methyl-4-oxo- cis-delta15-3- 1,2-dimyristoyl- a [lysine-biosynthesis-protein a 1,2-diacyl- (12Z,15Z)-9,10- 1,2-dicis- embB transferase: murG 7,8-dihydro-3H-pteridin- γ [+ 5 isozymes] sn-glycerol LysW]-C-terminal- -(5-phospho- CMP sn-glycerol dihydroxyoctadeca- vaccenoyl- hydroxyC34:1- 7-carboxy-4-methyl- 6-yl)]ethyl diphosphate acyl-carrier protein acyl-carrier protein EspD mycobacterial acetyl-CoA L-glutamyl)-L-glutamate 12,15-dienoate [acyl-carrier 3-phosphate 3-phosphate phosphatidate phytenal Rv1887 arabinogalactan 5-oxoheptanoyl-CoA decaprenyl- protein] containing Rv3127 pyrophosphoryl-(N dehydratase: extended α(1-> Probable 7-carboxy- -acetylglucosamine) hadA hadB 3) arabinofuran leucyl-tRNA 5-methyl-4- leu + a [lysine-biosynthesis-protein -N-acetylmuramyl- synthetase: oxoheptanoyl-CoA maltoheptaose androstan- a secondary Rv2532c linkages H (E)-4-coumaroyl-CoA malonyl-CoA NADPH γ D-glucopyranose long chain O-ureido-L- (pentapeptide) LysW]-C-terminal- -(L-glutamate asp 3α,17β-diol alcohol a protein leuS a trans-delta2-cis- dehydrogenase: polyphosphate homoserine arabinogalactan:decaprenyl- 5-semialdehyde-2-yl)-L-glutamate Rv0787 an L-leucyl-Leu fadE32 Chalcone synthase Probable β delta15-C34:2-[acp] polyphosphate- Possible 20-beta- probable zinc- Rv1686c phosphoryl- -D- [tRNA ] Pks10: pks10 Probable N-acetyl- Probable probable ATP- Leu glycogen hydroxysteroid type alcohol arabinofuranose β(1-->2) gamma-glutamyl- dependent argininosuccinate dependent a tRNA (2E)-7-carboxy-4-methyl- phosphorylase dehydrogenase: dehydrogenase: arabinofuranosyltransferase: aftB Chalcone synthase glucokinase: phoshate reductase GlgP: glgP synthase CLP protease: Rv3630 5-oxohept-2-enoyl-CoA ppgK fabG3 adhD mycobacterial a peptidoglycan trans-delta2-cis- trans-delta2-cis- Pks11: pks11 ArgC: argC ArgG: argG clpP2 clpP1 a [lysine-biosynthesis-protein α-D- 17-β- arabinogalactan dimer (mycobacteria) delta15-C34:2- delta15-C34:3- long chain D-glucopyranose Rv2602 possible enoyl- isoliquiritigenin LysW]-C-terminal-γ-(5-phospho- glucopyranose maltohexaose hydroxyandrostan- [+ 2 isozymes] MprB containing α(1- [acp] isomerase: [acp]:NADH+ polyphosphate 6-phosphate canavaninosuccinate a peptide CoA hydratase: L-glutamyl)-L-glutamate β echA10 1-phosphate 3-one a ketone >3) and (1-> oxidoreductase: echA12 2) arabinofuran Probable inhA SecY valyl-tRNA linkages trans-delta2-cis- [+ 8 isozymes] lipid II (meso peptidoglycan synthase peptideglycan DD- val delta15-C34:2- (3R)-7-carboxy-3-hydroxy-4- SecE Rv1096 diaminopimelate transglycosylase/ protein: 3-oxo-2-(cis-2’-pentenyl)- maltopentaose a ribonucleoside dTDP-4-dehydro- transpeptidase: [acp] isomerase: methyl-5-oxoheptanoyl-CoA a palmitoyl-[(hydroxy) a (6S)-5- containing) L,D valS cyclopentane-1-(3-oxooctanoyl)-CoA glu 2’,3’-cyclic lys 6-deoxy-α-D- cys pbpA echA11 a cis-delta15-C34:1-[acp] phthioceranic acid synthase] formyltetrahydrofolate glucopyranose transpeptidase: ldtA an L-valyl-Val Probable phosphate Lhr Probable acetyl-CoA α α peptidoglycan [tRNA ] probable 3- probable probable , ’-trehalose Val acyltransferase: fadA2 C40- glycogen cyclic nucleotide Lysine N- a mycobacterial transglycosylase: hydroxybutyryl- dTDP-4-amino- α a tRNA folylpolyglutamate cystathionine 6- -mycolate arabinogalactan cis-delta15-C34:1- hydroxyphthioceranyl- phosphorylase phosphodiesterase: acetyltransferase 4,6-dideoxy- rodA CoA Probable beta-ketoacyl synthase beta- EfpA a cis,cis-delta3,15-C34:2-[acp] [acyl-carrier CoA synthase: pks2 GlgP: glgP Rv0805 MbtK: mbtK D-glucose Rv1804c dehydrogenase: CoA thiolase FadA3: fadA3 protein: folC synthase: cbs lipid II (meso a peptidoglycan a peptidoglycan protein]:malonyl- α transaminase: fadB3 3-oxo-2-(cis-2’-pentenyl)- a C40-hydroxyphthioceranyl- -D- a ribonucleoside 6 Rv1866 arabinogalactan: diaminopimelate with D,D cross- with L,D cross- [acyl-carrier protein] acetyl-CoA a (6S)-5- Rv3402c cyclopentane-1-hexanoyl-CoA [(hydroxy)phthioceranic glucopyranose maltotetraose 2’-phosphate N -acetyl-L-lysine lanthionine trehalose- containing) links (mycobacteria) links (mycobacteria) cis,cis-delta3,15- malonyltransferase: formyltetrahydrofolate 7-carboxy-4-methyl-3,5- acid synthase] 1-phosphate dTDP-viosamine mono-mycolate C34:2-[acyl-carrier kasA Probable dioxoheptanoyl-CoA Rv2877c mycolyltransferase: alanyl-tRNA protein]:malonyl- EsxV ala fbpB synthetase: [acyl-carrier protein] [+ 2 isozymes] Rv1140 alaS malonyltransferase: 3-oxo-2-(cis-2’-pentenyl)- 2-phospho-4-(cytidine 5’- N-acetyl-D- a nucleoside probable beta- a glycogen acetoacetyl-CoA D-mannitol an L-alanyl-Ala kasB a cis-delta17-3- cyclopentane-1-(3-oxohexanoyl)-CoA diphospho)-2-C-methyl-D-erythritol galactosamine cyclic 3’,5’- a malonyl-[acp] arabinogalactan: ketoacyl CoA [tRNA ] oxo-C36:1-[acp] Probable acetyl-CoA 6-phosphate monophosphate trehalose- Ala thiolase: fadA3 Probable 2C-methyl- Probable 3-hydroxybutyryl- Probable NADP- Rv1780 a tRNA [+ 2 isozymes] acyltransferase: fadA2 Probable N- 3-oxoacyl- mono-mycolate D-erythritol 2,4- glycogen cyclic nucleotide CoA dependent Rv1396c cis-delta17-3- acetylglucosamine- [acp] mycolyltransferase: probable cyclodiphosphate phosphorylase phosphodiesterase: dehydrogenase: alcohol Rv2971 a cis,cis-delta5,17- oxo-C36:1-[acp] Probable beta-ketoacyl 6-phosphate synthase: fbpA acetyl-CoA synthase: ispF GlgP: glgP Rv0805 fadB2 dehydrogenase 3-oxo-C36:2-[acp] reductase: fabG1 CoA thiolase FadA3: fadA3 deacetylase: nagA fabH acyltransferase: α-D- (S)-3- AdhC: adhC 3-oxo-2-(cis-2’-pentenyl)- 2-C-methyl-D-erythritol- D-galactosamine a nucleoside 5’- a 3- fadA2 acetyl-CoA RplC [+ 3 isozymes] CMP acetate glucopyranose maltotetraose hydroxybutanoyl- aldehydo- oxodocosanoyl- arabinogalactan: cis,cis-delta5,17- cyclopentane-1-butanoyl-CoA 2,4-cyclodiphosphate 6-phosphate monophosphate 1-phosphate CoA D-mannose [acp] trehalose- asn 3-oxo-C36:2-[acp] a cis-delta17-3- Rv3587c Rv3693 mono-mycolate reductase: fabG1 hydroxyC36:1-[acp] 5-carboxy-2-methyl- acetyl-CoA mycolyltransferase: an L-asparaginyl- Asn [+ 3 isozymes] 3-oxopentanoyl-CoA 1498 fbpC [tRNA ] a long-chain a Chi-site containing (9Z,15Z)-12,13-epoxy- a uracil a 3,5,7,9,11,13,15- Rv2146c Asn cis-delta17-3- 6-trans-3-oxo-tridecenoyl-CoA α-linolenate a cis,cis-delta5,17-3- fatty acid double stranded RecA octadeca-9,15-dienoate in 16S rRNA hepta-oxo- cys tRNA hydroxyC36:1- DNA with a blunt end hexadecanoyl-[PKS-acp] hydroxyC36:2[acp] Probable acetyl-CoA acyl-CoA acyl-CoA Ribosomal RNA Rv2490c Rv2209 [acyl-carrier probable Possible epoxide a mycolyl- acyltransferase: fadA2 synthetase: fadD32 Possible probable protein] synthetase: hydrolase: ephF small subunit arabinogalactan- β exonuclease ketoacyl cystathionine dehydratase: fatty acid -oxidation I succinyl-CoA propanoyl-CoA fadD32 methyltransferase peptidoglycan cis,cis-delta5,17- Probable beta-ketoacyl [+ 21 isozymes] V (alpha [+ 6 isozymes] reductase: beta- hadA hadB E: rsmE Rv1749c complex 3-hydroxyC36:2- CoA thiolase FadA3: fadA3 chain): recD 3 Rv1544 synthase: cbs a long-chain (9Z,15Z)-12,13- [acyl-carrier a (3Z)-alk-3- AMP diphosphate α-linolenoyl-CoA AMP diphosphate a double stranded DNA an N - 1498 9-hydroxy-3,5,7,11,13,15- asp acetyl-CoA acyl-CoA dihydroxyoctadeca- Rv3659c protein] 4-trans-undecenoyl-CoA with a RecA protein methyluracil hexaoxohexadecanoyl- Rv2103c a trans-delta2-cis- enoyl-CoA 9,15-dienoate ser dehydratase: loaded 3’ overhang in 16S rRNA [PKS-acp] delta17-C36:2-[acp] an L-aspartyl-asp hadA hadB [tRNA ] PafB asp tRNA trans-delta2-cis- a trans-delta2-cis,cis a long-linear an oxidized RpsP delta17-C36:2- (6Z,9Z,12Z,15Z,18Z,21Z)-3- all-trans- Metabolic Regulator Biosynthesis a trans-2- 1,4-dihydroxy- α trans-aconitate -5,17-C36:3-[acp] oxotetracosahexaenoyl-CoA undecaprenyl -D-glucan a protein fMet nitroaromatic EsxH [acp]:NADH+ H 2 O ATP 2-naphthoate enoyl-CoA compound oxidoreductase: acyl-CoA Probable acetyl-CoA diphosphate Probable enoyl-CoA trans-aconitate synthetase: acyltransferase: fadA2 Nucleoside triphosphate 1,4-dihydroxy- Probable Putative LppJ ppGpp biosynthesis trans-delta2- inhA 3-hydroxybutyryl- glycogen mannosylglucosylglycerate glucosylglycerate biosynthesis I trehalose biosynthesis I trehalose biosynthesis III a 2,3,4-saturated hydratase: a (3R)-3- methyltransferase: membrane bound polypeptide NAD(P)H trehalose biosynthesis V cis,cis-5,17-C36:2- coenzyme A fadD32 pyrophosphohydrolase: 2-naphthoate phosphorylase fatty acid echA9 CoA tam deformylase: Rv2161c biosynthesis I Probable acyl-CoA hydroxyacyl-CoA Probable beta-ketoacyl mazG prenyltransferase: GlgP: glgP metalloprotease: rip nitroreductase [acp]:NADH+ [+ 21 isozymes] epimerase: fadB CoA thiolase FadA3: fadA3 menA def acg: acg pppGpp tyrosyl- oxidoreductase: a cis-delta17-C36:1-[acp] dehydrogenase: [+ 18 isozymes] + α (E)-3- Rv3899c a glycogen GDP-α-D-glucose 3-phospho-D-glycerate D-glucopyranose 6-phosphate UDP-α-D-glucose α-D-glucose 6-phosphate α (4Z,7Z,10Z,13Z,16Z,19Z) AMP diphosphate H -D- a reduced GDP- -D-glucose tRNA inhA fadE5 acetyl-CoA a long-linear (methoxycarbonyl) guanosine pentaphosphate 3-phospho-D-glycerate tyr a 2,3,4-saturated DMKH2-11 glucopyranose a peptide formate met nitroaromatic synthase: a 2,3,4-saturated -docosahexaenoyl-CoA α-D-glucan pent-2-enedioate Hsp synthetase: gpsI Probable glucosyl-3- alpha, alpha-trehalose- alpha, alpha-trehalose- [+ 27 isozymes] (3S)-3- 1-phosphate compound Probable glucosyl-3- tyrS fatty acyl CoA phosphoglycerate cis-delta17-C36:1- hydroxyacyl-CoA phosphoglycerate phosphate synthase phosphate synthase WhiA Probable GTP synthase GpgS: gpgS an L-tyrosyl-Tyr a cis,cis-delta5,17-C36:2-[acp] [acyl-carrier guanosine 3’-diphosphate synthase GpgS: gpgS a maltodextrin [UDP-forming]: otsA [GDP-forming]: otsA pyrophosphokinase: relA 2-O-(α-D-glucopyranosyl) [tRNA ] protein]:malonyl- 5’-triphosphate 3’- 2-O-(α-D-glucopyranosyl) α,α-trehalose 6-phosphate α,α-trehalose 6-phosphate Tyr 3-hydroxyacyl-CoA Rv3508 -3-phospho-D-glycerate a tRNA all-trans- 1-myristoyl- 3-hydroxyisovaleryl- [acyl-carrier protein] dehydrogenase: 3-oxo-2-(cis-2’-pentenyl)- 1,4-dihydroxy- maltotetraose diphosphatase: relA -3-phospho-D-glycerate Maltooligosyltrehalose pristanate palmitoleoyl-CoA sn-glycerol AftD cis,cis-delta5,17- malonyltransferase: Probable fadB3 cyclopentane-1-(3-oxobutanoyl)-CoA dodecaprenyl met CoA synthase TreY: treY 2-naphthoate 3-phosphate Glucosyl-3- trehalose 6-phosphate trehalose 6-phosphate C36:2-[acyl-carrier kasA acetyl-CoA diphosphate Probable acetyl-CoA acyl-CoA Probable probable acyl-CoA steroid Rv0686 phosphoglycerate phosphatase: otsB2 phosphatase: otsB2 protein]:malonyl- acyltransferase: 1,4-dihydroxy- 1-acylglycerol- Probable a 2,3,4-saturated a 2,3,4-saturated acyltransferase: fadA2 synthetase: fadD32 glycogen dehydrogenase: L-glutamate alpha- enoyl-CoA phosphatase trehalose biosynthesis II [acyl-carrier protein] 3-phosphate O- maltooligosyltrehalose [+ 2 isozymes] fatty acyl CoA fadA2 3-oxoacyl-CoA 2-naphthoate phosphorylase fadE35 N-acetyltranferase: α α α α Probable beta-ketoacyl [+ 21 isozymes] acyltransferase: hydratase: GTP ppGpp 2-[2-O-(α-D-mannopyranosyl) GpgP: gpgP , -trehalose , -trehalose malonyltransferase: prenyltransferase: GlgP: glgP argA LprO synthase TreX: treX Probable echA9 kasB a cis-delta19-3- [+ 2 isozymes] CoA thiolase FadA3: fadA3 menA [+ 27 isozymes] Rv2182c Rv3486 -(1->2)-α-D-glucopyranosyl]- α α 2-O-(α-D-glucopyranosyl) D-glucopyranose 6-phosphate ADP- -D-glucose tryptophanyl- oxo-C38:1-[acp] AMP diphosphate pristanoyl-CoA -D- (2E,9Z)- 1,2-dimyristoyl- (E)-2- 3-phospho-D-glycerate a maltooligosyl- acetyl-CoA (+)-7-epi-jasmonoyl-CoA N-acetyl-L- Mpa -D-glycerate Trp tRNA DMK-12 glucopyranose maltotriose hexadecenoyl-CoA sn-glycerol methylcrotonoyl- alpha, alpha-trehalose- a tRNA [+ 2 isozymes] methionine trehalose synthetase: 1-phosphate 3-phosphate CoA Glucosyl-3- phosphate synthase trehalose cis-delta19-3- Probable GTP phosphoglycerate biosynthesis IV trpS a cis,cis-delta7,19- oxo-C38:1-[acp] Maltooligosyltrehalose [ADP-forming]: otsA an L-tryptophanyl- FbpD pyrophosphokinase: relA phosphatase Trp 3-oxo-C38:2-[acp] reductase: fabG1 Rv3454 trehalohydrolase α,α-trehalose 6-phosphate [tRNA ] acetyl-CoA guanosine-3’,5’- GpgP: gpgP 1-palmitoyl- TreZ: treZ α-maltose an all-trans- (7Z)- a holo Rv0283 [+ 3 isozymes] 4-hydroxybenzoyl-acetyl-CoA phytenate 1,4-dihydroxy- bis(diphosphate) 3’- α trp cis,cis-delta7,19- polyisoprenyl asp hexadecenoyl-CoA mycolipanoic sn-glycerol a dodecanoyl-[acp] Probable nucleoside 2-[2-O-( -D- trehalose 2-naphthoate diphosphatase: relA trehalose 6-phosphate 3-oxo-C38:2-[acp] 3-phosphate diphosphate kinase: ndkA α α α a cis-delta19-3- Probable acetyl-CoA acyl-CoA diphosphate probable acyl-CoA acid synthase mannopyranosyl)-(1->2)- - , -trehalose phosphatase: otsB2 synthase: reductase: fabG1 1,4-dihydroxy- Probable aspartate 1-acylglycerol- D-glucopyranosyl]-D-glycerate treS hydroxyC38:1-[acp] acyltransferase: fadA2 synthetase: fadD32 dehydrogenase: fatty acid GDP 2-naphthoate aminotransferase: aspC mycolipanoate 3-phosphate O- EsxO EsxR α α [+ 3 isozymes] fadE35 synthase: , -trehalose α,α-trehalose Probable beta-ketoacyl [+ 21 isozymes] prenyltransferase: synthase: pks3 acyltransferase: NarU Possible aspartate fas cis-delta19-3- CoA thiolase FadA3: fadA3 menA [+ 27 isozymes] Rv2182c Probable a cis,cis-delta7,19-3- aminotransferase: aspB hydroxyC38:1- diphosphate AMP phytenoyl-CoA (2E,7Z)- C29-mycolipanoyl- 1-palmitoyl- threonyl- hydroxyC38:2-[acp] acetyl-CoA 4-hydroxybenzoyl-CoA a (2E)-dodec- [acyl-carrier DMKH 2 oxaloacetate hexadecenoyl-CoA [mycolipanoic 2-myristoyl tRNA 2-enoyl-[acp] protein] acid synthase] phosphatidate thr synthetase: Rv0143c Rv3004 cis,cis-delta7,19- dehydratase: thrS CsoR 3-hydroxyC38:2- hadA hadB Aromatic Compound Degradation an L-threonyl-Thr [acyl-carrier [tRNA ] + all-trans- (7Z)- a holo 1-palmitoyl- Thr protein] H (E)-4-coumaroyl-CoA malonyl-CoA linoleate 1,4-dihydroxy- a tRNA a trans-delta2-cis- tridecaprenyl thr tetradecenoyl-CoA mycolipanoic sn-glycerol an octanoyl-[acp] dehydratase: protocatechuate 2-naphthoate 3-phosphate Rv3391 delta19-C38:2-[acp] nitrobenzene degradation I paraoxon degradation Chalcone synthase acyl-CoA diphosphate probable acyl-CoA acid synthase hadA hadB degradation II (ortho- Probable L-serine 1-acylglycerol- Rv1174c Rv2768c Pks10: pks10 synthetase: fadD32 1,4-dihydroxy- dehydrogenase: C27- fatty acid cleavage pathway) dehydratase: sdaA 3-phosphate O- 2-naphthoate fadE35 mycolipanoate synthase: trans-delta2-cis- Chalcone synthase [+ 21 isozymes] acyltransferase: nitrobenzene paraoxon prenyltransferase: a trans-delta2-cis-cis- delta19-C38:2- Probable threonine synthase: pks3 fas protocatechuate Pks11: pks11 menA [+ 27 isozymes] Rv2182c delta7-19-C38:3-[acp] Probable dehydratase IlvA: ilvA SERYL-tRNA [acp]:NADH+ AMP diphosphate linoleoyl-CoA (2E,7Z)- C27-mycolipanoyl- 1-palmitoyl-2- Rv1527c ser phosphotriesterase: php naringenin chalcone a (2E)-oct- synthetase: oxidoreductase: DMKH2-13 2-oxobutanoate tetradecenoyl-CoA [mycolipanoic cis-vaccenoyl Rv0204c 2-enoyl-[acp] Rv3364c serS trans-delta2- inhA diethylphosphate 4-nitrophenol acid synthase] phosphatidate 3-carboxy-cis nitrosobenzene an L-seryl-ser cis,cis-delta7- [tRNA ] ,cis-muconate ser 19-C38:3- a tRNA [acp]:NADH+ a cis-delta19-C38:1-[acp] all-trans- (11Z)-(S)-3- luteolin 7-O-β- Rv0779c oxidoreductase: 6-cis, 3-oxo-tridecenoyl-CoA decanoate 1,4-dihydroxy- cis-vaccenoyl-CoA Rv3814c parathion degradation hexaprenyl hydroxyhexadec- D-diglucuronide repressor LexA inhA 2-naphthoate inosine RpfC diphosphate 11-enoyl-CoA cis-delta19-C38:1- Probable acetyl-CoA acyl-CoA probable acyl-CoA possible N-phenylhydroxylamine [acyl-carrier (2-carboxy- acyltransferase: fadA2 synthetase: fadD32 1,4-dihydroxy- adenosine dehydrogenase: enoyl-CoA peroxidase: Repressor protein]:malonyl- 2,5-dihydro- parathion 2-naphthoate nucleosidase: fadE35 hydratase: bpoB a cis,cis-delta7,19-C38:2-[acp] Probable beta-ketoacyl [+ 22 isozymes] LexA: lexA Rv1863c Probable [acyl-carrier protein] 5-oxofuran- Probable prenyltransferase: iunH echA2 CoA thiolase FadA3: fadA3 [+ 3 isozymes] Rv3064c prolyl-tRNA 2-yl)-acetate hydroxylaminobenzene menA [+ 27 isozymes] pro malonyltransferase: [+ 18 isozymes] a radical of synthetase: diphosphate AMP decanoyl-CoA hypoxanthine D-ribofuranose (2E,11Z)- cleaved LpqC kasA mutase Hab: hab Probable acetyl-CoA 4-cis-undecenoyl-CoA (2E,11Z)-hexadec- luteolin-7-O- proS cis,cis-delta7,19- Possible 4- demethylmenaquinol-6 octadecenoyl-CoA repressor LexA phosphotriesterase: 2,11-dienoyl-CoA diglucuronide an L-prolyl-Pro C38:2-[acyl-carrier carboxymuconolactone [tRNA ] protein]:malonyl- [+ 2 isozymes] 2-aminophenol php Pro decarboxylase Rv1468c [acyl-carrier protein] Rv2331 a tRNA a cis-delta21-3- (CMD): Rv0771 malonyltransferase: oxo-C40:1-[acp] all-trans- (S)-3- a debranched Rv1441c kasB (4,5-dihydro- 4-nitrophenol 4-trans-3-oxo-undecenoyl-CoA 1,4-dihydroxy- diethylthiophosphate oleate heptaprenyl NADH oleoyl-CoA hydroxyhexanoyl- α-limit dextrin 5-oxofuran- 2-naphthoate a decanoyl-[acp] diphosphate CoA cis-delta21-3- 2-yl)-acetate Probable acetyl-CoA acyl-CoA NADH probable acyl-CoA Probable [+ 2 isozymes] Rv1812c oxo-C40:1-[acp] acyltransferase: fadA2 synthetase: fadD32 1,4-dihydroxy- pyrophosphatase: dehydrogenase: enoyl-CoA glycogen fatty acid Rv0111 reductase: fabG1 2-naphthoate fadE35 hydratase: probable a cis,cis-delta9,21- [+ 21 isozymes] nudC phosphorylase synthase: Probable beta-ketoacyl prenyltransferase: echA2 phenylalanyl- 3-oxo-C40:2-[acp] GlgP: glgP fas Rv2487c [+ 3 isozymes] CoA thiolase FadA3: fadA3 menA reduced β- [+ 27 isozymes] tRNA α phe diphosphate AMP oleoyl-CoA AMP nicotinamide D- (2E,9Z)- [+ 18 isozymes] -D- synthetase: 3-oxoadipate diethylphosphate acetyl-CoA 2-trans-nonenoyl-CoA trans-hex-2- a (2E)-dec- cis,cis-delta9,21- a cis-delta21-3- demethylmenaquinol-7 ribonucleotide octadecenoyl-CoA glucopyranose Rv2159c pheS pheT enoyl-CoA 2-enoyl-[acp] Rv2273 3-oxo-C40:2-[acp] hydroxyC40:1-[acp] 1-phosphate an L-phenylalanyl- Phe reductase: fabG1 [tRNA ] Phe Rv0285 a tRNA [+ 3 isozymes] cis-delta21-3- hydroxyC40:1- all-trans- (S)-3- (5E)-3-oxo-dodec-5-enoyl-CoA adenosylcobinamide-GDP α-ribazole 1,4-dihydroxy- 1,4-dihydroxy- L-fuculose 1-phosphate (2E,6E)-farnesol Rv1777 a cis,cis-delta9,21-3- [acyl-carrier octaprenyl GGPP hydroxybutanoyl- a hexanoyl-[acp] Rv2969c 2-naphthoate 2-naphthoate hydroxyC40:2-[acp] protein] Alcohol Degradation Probable acetyl-CoA diphosphate CoA Probable cobalamin Possible (2E,6E)- dehydratase: acyltransferase: fadA2 1,4-dihydroxy- 1,4-dihydroxy- 3-hydroxybutyryl- 5’-phosphate L-fuculose farnesol ω- fatty acid hadA hadB 2-naphthoate 2-naphthoate CoA cis,cis-delta9,21- synthase CobS: cobS phosphate hydroxylase: synthase: Rv2082 Methionyl- ethanol degradation II Probable beta-ketoacyl prenyltransferase: prenyltransferase: dehydrogenase: 3-hydroxyC40:2- aldolase: fucA cyp124 fas tRNA glycerol and glycerophosphodiester degradation CoA thiolase FadA3: fadA3 menA menA Rv1404 met [acyl-carrier ethanol fadB3 Rv0010c synthetase: a trans-delta2-cis- GMP adenosylcobalamin (2E,6E,10E)-2,6,10- DHAP a (2E)-hex- protein] delta21-C40:2-[acp] degradation I acetyl-CoA (3E)-dec-3-enoyl-CoA demethylmenaquinol-8 demethylmenaquinol-4 (S)-lactaldehyde trimethyldodeca- metS an L-methionyl- ethanol acetoacetyl-CoA 2-enoyl-[acp] dehydratase: 2,6,10-triene-1,12-diol [elongator a glycerophosphodiester Met hadA hadB Probable NADP- tRNA ] trans-delta2-cis- ethanol EsxQ elongatorMet glycerol delta21-C40:2- dependent alcohol glycerolphosphodiesterase: Rv0312 tRNA Rv3656c dehydrogenase Rv2277c Probable NADP- 1518 a trans-delta2-cis,cis [acp] isomerase: Probable glycerol + α-D-glucopyranosyl-(1->6)-2-O- all-trans- adenine / (5Z)- 3-[(4’- stearoyl- AdhC: adhC dependent H malonyl-CoA (E)-cinnamoyl-CoA 1,4-dihydroxy- 1519 -9,21-C40:3-[acp] echA10 [+ 2 isozymes] kinase: glpK (α-D-glucopyranosyl)-D-glycerate decaprenyl adenine in 16S rRNA tetradecenoyl-CoA methylsulfanyl) [mycocerosic a palmitoyl-[acp] alcohol 2-naphthoate Chalcone synthase diphosphate butyl]malate acid synthase] [+ 5 isozymes] dehydrogenase possible acyl-CoA Diglucosylglycerate 1,4-dihydroxy- Probable trans-delta2- trans-delta2-cis- acetaldehyde Pks10: pks10 dehydrogenase: probable 3- fatty acid Rv0063 AdhC: adhC octanoyltransferase: dimethyladenosine mycocerosate Rv1372 Lysyl-tRNA delta21-C40:2- 2-naphthoate fadE16 isopropylmalate MptA cis,cis- octT transferase: ksgA synthase: synthetase [acp] isomerase: Chalcone synthase prenyltransferase: dehydrogenase: synthase: mas delta9,21-C40:3- [+ 5 isozymes] 6 1518 fas 2 LysX: lysX echA11 probable aldehyde sn-glycerol 3-phosphate Pks11: pks11 6-O-octanoyl-α-D- menA N -dimethyladenine [+ 27 isozymes] leuB [acp]:NADH+ acetaldehyde 6 1519 C30-mycocerosyl- dehydrogenase: glucopyranosyl-(1->6)-2-O-(α- /N -dimethyladenine (2E,5Z)- 7-(methylsulfanyl) a (2E)-hexadec- Lys oxidoreductase: pinocembrin chalcone [mycocerosic Lysyl-tRNA Rv0458 D-glucopyranosyl)-D-glycerate DMKH2-10 in 16S rRNA tetradecenoyl-CoA 2-enoyl-[acp] a tRNA inhA glycerol-3-phosphate -2-oxoheptanoate acid synthase] Rv3722c synthetase a cis,cis-delta3,21-C40:2-[acp] acetaldehyde Rv1357c RpsB [+ 4 isozymes] dehydrogenase: glpD2 1: lysS dehydrogenase: an L-lysyl- Lys glycerol-3-phosphate hsaG acetate [tRNA ] a cis,cis-delta9,21-C40:2-[acp] cis,cis-delta3,21- dehydrogenase: glpD1 5-methoxy-6-methylbenzimidazole (5Z)- (S)-3- C402:2-[acyl-carrier adenosylcobinamide-GDP 3-oxo-(5Z)-dodecenoyl-CoA a nucleoside geranylgeraniol a RNA-DNA hybrid lys acetyl-CoA ribotide phosphate dodecenoyl-CoA hydroxybutanoyl- a myristoyl-[acp] triphosphate HspX protein]:malonyl- Acetyl-coenzyme DHAP CoA Rv3345c Rv0328 cis,cis-delta9,21- probable cobalamin 5’- probable beta-ketoacyl probable acyl-CoA Probable [acyl-carrier protein] A synthetase: acs Nucleoside triphosphate geranylgeraniol enoyl-CoA C40:2-[acyl-carrier phosphate synthase: cobS CoA thiolase: fadA3 ω dehydrogenase: ribonuclease fatty acid malonyltransferase: pyrophosphohydrolase: -hydroxylase: hydratase: protein]:malonyl- fadE35 HII protein: synthase: kasB probable acetyl-CoA cyp124 echA2 acetyl-CoA α α mazG fas [acyl-carrier protein] Co -[ -(5-methoxy-6-methylbenzimidazolyl) acyltransferase: fadA2 rnhB Probable GMP [+ 27 isozymes] malonyltransferase: ]-Coβ-adenosylcobamide 5’-phosphate (2E,6E,10E,14E)-2,6,10,14- [+ 2 isozymes] a nucleoside 5’- (2E,5Z)- a nucleoside 5’- [+ 18 isozymes] Rv1279 Rv1762c histidyl-tRNA acetyl-CoA tetramethylhexadeca- a (2E)-tetradec- Rv2575 his kasB (3Z)-dec-3-enoyl-CoA monophosphate DNA synthetase: 2,6,10,14-tetraene-1,16-diol dodecenoyl-CoA monophosphate crotonyl-CoA 2-enoyl-[acp] a cis,cis-delta5,23- Carboxylate Degradation hisS [+ 2 isozymes] 3-oxo-C42:2-[acp] an L-histidyl-His [tRNA ] His a cis,cis-delta11,23- 2-methylcitrate cis,cis-delta5,23- + MihF a tRNA propanoyl CoA pyruvate fermentation to acetate IV an organic 3-[(5’- CydC 3-oxo-C42:2-[acp] cycle I a lipid II H isovaleryl-CoA malonyl-CoA uroporphyrinogen-III hydrogen bromide oxaloacetate [DNA] 3-oxo-C42:2-[acp] degradation I molecule methylsulfanyl) a stearoyl-[acp] Rv3655c reductase: fabG1 pentyl]malate pyruvate fermentation probable penicillin- uroporphyrinogen-III C- cis,cis- Chalcone synthase bromide iron-regulated Probable DNA propanoate pyruvate to acetate II binding protein: dacB1 methyltransferase: cysG probable 3- delta11,23-3- [+ 3 isozymes] propanoyl-CoA Pks10: pks10 peroxidase: phosphoenolpyruvate polymerase fatty acid isopropylmalate [+ 3 isozymes] bpoC IV: dinX synthase: oxo-C42:2-[acp] Chalcone synthase uroporphyrin-III C- carboxykinase Rv1231c Rv1730c a cis,cis-delta5,23-3- propionyl-CoA dehydrogenase: fas Probable reductase: fabG1 pyruvate a N-acetylglucosamine--N- Pks11: pks11 [GTP]: pckA hydroxyC42:2-[acp] carboxylase: methyltransferase: hemD [+ 2 isozymes] leuB [+ 2 isozymes] glycyl-tRNA D-ala acetylmuramyl-(tetrapeptide) Rv1435c gly propanoyl-CoA accE5 pyruvate an organobromine phosphoenol a nucleoside 5’- a (2E)-octadec- synthetase: [+ 3 isozymes] pyrophosphoryl-undecaprenol 6-isobutyl-4-hydroxy-2-pyrone precorrin-2 8-(methylsulfanyl) dehydrogenase: compound pyruvate -2-oxooctanoate monophosphate 2-enoyl-[acp] glyS cis,cis-delta5,23- [+ 2 isozymes] lpdC dlaT aceE Gly a cis,cis-delta11,23- (S)-methylmalonyl- a glycyl-[tRNA ] 3-hydroxyC42:2- Probable acetyl-CoA formate Rv1215c Rv1683 3-hydroxyC42:2-[acp] CoA acetyl-CoA Gly [acyl-carrier methylcitrate a tRNA synthase Rv0669c protein] Probable phosphate S-(2-hydroxyacyl) 3-oxo-(7Z)- 3-[(6’- 1-oleoyl-sn cis,cis-delta11,23- dehydratase: PrpC: prpC Probable phosphate (9Z,12Z,15Z,18Z,21Z)- L-cysteate (S)-lactaldehyde acetyltransferase: pta a ferrocytochrome b 5 glutathione tetradecenoyl-CoA methylsulfanyl) -glycerol 3- lys 3-hydroxyC42:2- hadA hadB acetyltransferase: pta tetracosapentaenoyl-CoA hydroxyacylglutathione Probable aspartate hexyl]malate phosphate [acyl-carrier (2S,3S)-2- probable beta- probable aldehyde LepA (R)-methylmalonyl- Possible linoleoyl-CoA hydrolase: Rv0634c aminotransferase: aspC probable 3- 1-acylglycerol- Rv0484c protein] methylcitrate acetyl phosphate ketoacyl CoA dehydrogenase Lysine-N- a trans-delta2-cis,cis- CoA desaturase (delta(6) isopropylmalate 3-phosphate O- dehydratase: acetyl phosphate thiolase: fadA3 (NAD+) oxygenase: Methionyl- delta5,23-C42:3-[acp] -desaturase): desA3 glyoxalase Possible aspartate dehydrogenase: acyltransferase: Rv1419 Possible dependent: Rv0147 mbtG tRNA hadA hadB (6Z,9Z,12Z,15Z,18Z,21Z) II: Rv2581c [+ 2 isozymes] aminotransferase: aspB leuB Rv2182c met methylcitrate probable Probable acetate a ferricytochrome b 6 synthetase: Probable acetate 5 -tetracosahexaenoyl-CoA a 2-hydroxy dehydratase methylmalonyl- kinase: ackA glutathione (5Z)-dodecenoyl-CoA acetyl-CoA 3-sulfopyruvate (S)-lactate 9-(methylsulfanyl) dioleoyl N -hydroxy- metS trans-delta2- carboxylate Rv0804 Rv1636 a trans-delta2-cis,cis- PrpD: prpD CoA mutase: kinase: ackA -2-oxononanoate phosphatidate L-lysine an L-methionyl- cis,cis- Met delta11,23-C42:3-[acp] mutA mutB [initiator tRNA ] delta5,23-C42:3- acetate Met cis-2- acetate initiator tRNA [acp]:NADH+ Rv2481c methylaconitate trans-delta2- oxidoreductase: succinyl-CoA 2 4 α α (R)-S- all-trans- trans-Δ , cis-Δ - 3-[(3’- (S)-3- (25S)-3 ,7 - cis,cis- inhA (9Z,12Z,15Z,18Z)- a 1-haloalkane Zur a ferrocytochrome b lactoylglutathione retinyl palmitate methylsulfanyl) hydroxyhexadecanoyl- dihydroxy-5β- BfrA tetracosatetraenoyl-CoA 5 decadienoyl-CoA delta11,23-C42:3- propyl]malate CoA cholestanoyl-CoA hydroxyacylglutathione haloalkane Probable [acp]:NADH+ Possible linoleoyl-CoA Probable NADPH hydrolase: Rv2581c probable 3- steroid oxidoreductase: pyruvate decarboxylation to acetyl CoA dehalogenase: carboxylesterase dependent 2,4- a cis,cis-delta5,23-C42:2-[acp] (2R,3S)-2- desaturase (delta(6) isopropylmalate enoyl-CoA x racemase: Rv0279c inhA Rv2296 LipQ: lipQ dienoyl-CoA methylisocitrate superpathway of acetate -desaturase): desA3 hydroxyacylglutathione dehydrogenase: hydratase: mcr reductase: fadH Rv1588c hydrolase: Rv0634c a [pyruvate utilization and formation (6Z,9Z,12Z,15Z,18Z)- [+ 2 isozymes] [+ 2 isozymes] leuB echA9 α α Rv3684 cis,cis-delta5,23- a ferricytochrome b 5 (25R)-3 ,7 - a cis,cis-delta11,23- dehydrogenase 6 tetracosapentaenoyl-CoA 6-(methylsulfanyl) (2E)- β C42:2-[acyl-carrier (R)-lactate glutathione a halide anion a primary alcohol palmitate all-trans-retinol (2E)-dec-2-enoyl-CoA dihydroxy-5 - C42:2-[acp] E2 protein] N -2-oxohexanoate hexadecenoyl-CoA protein]:malonyl- acetate cholestanoyl-CoA -lipoyl-L-lysine Acetyl- [acyl-carrier protein] succinate pyruvate pyruvate RpfE pyruvate coenzyme A cis,cis-delta11,23- malonyltransferase: decarboxylase: Rv3403c Probable synthetase: Rv0404 dihydrolipoamide aceE C42:2-[acyl-carrier kasB acetate 2+ (25S)-3α,7α,12α- dehydrogenase: acs DNA combined with exogenous DNA 3-oxo-(11Z)- a (2E,4E)-alka- protein]:malonyl- protoporphyrin IX Mg cholesterol β kinase: to form a recombinational junction octadecenoyl-CoA 2,4-dienoyl-CoA ethylphosphate trihydroxy-5 - [acyl-carrier protein] lpdC 4’-phosphopantetheine ATP [+ 2 isozymes] ackA Possible magnesium cholestanoyl-CoA malonyltransferase: probable beta- Probable NADPH acid 2+ 2+ a [pyruvate Probable crossover junction cholesterol C26- Mg MgtC Mg LprL citrate degradation a [pyruvate chelatase: Rv0958 ketoacyl CoA dependent 2,4- Rv3030 kasB a cis,cis-delta7,25- acetyl phosphate acetyl-CoA endodeoxyribonuclease: Probable monooxygenase: phosphatase: x racemase: dehydrogenase 6 dehydrogenase6 thiolase: fadA3 3-oxo-C44:2-[acp] ruvC phosphopantetheine dienoyl-CoA kshB cyp125 Rv2135c mcr E2 protein] N dihydrolipoamide E2 protein] N -S- Possible magnesium adenylyltransferase: kdtB reductase: fadH [+ 2 isozymes] -dihydrolipoyl- acyltransferase: acetyldihydrolipoyl- chelatase: Rv2850c [+ 2 isozymes] (25S)-3β- an acetyl-holo [citrate resolution of recombinational junction [+ 3 isozymes] (25R)-3α,7α,12α- Rv1101c cis,cis-delta7,25- citrate L-lysine dlaT L-lysine 3’-dephospho-CoA lyase acyl-carrier protein] formation of two intact strands Mg-protoporphyrin palmitoleoyl-CoA acetyl-CoA a trans-2-enoyl-CoA hydroxycholest- trihydroxy-5β- a cis,cis-delta13,25- 3-oxo-C44:2-[acp] ethanol Probable citrate 5-en-26-oate EsxC LppN 3-oxo-C44:2-[acp] reductase: fabG1 Probable phosphate cholestanoyl-CoA (pro-3S)-lyase acetyltransferase: pta (beta subunit): citE [+ 3 isozymes] acetyl-CoA cis,cis- a citryl-holo [citrate 3 Rv2542 delta13,25-3- lyase acyl-carrier protein] a holo-[4- an N -methyladenine 2-O-sulfo- a cis,cis-delta7,25-3- L-malate degradation II prephenate a nucleoside oxo-C44:2-[acp] glycerophosphoserine a (2S)-2-methylacyl-CoA α,α-trehalose histidinol hydroxyC44:2-[acp] 4-hydroxybenzoate hydroxyphenylalkanoate in DNA diphosphate Rv2254c reductase: fabG1 Rv0578c Probable citrate synthase] glycerolphosphodiesterase: fatty-acid-CoA P-hydroxybenzoyl- Probable DNA-3- 2-O-sulfo trehalose prephenate Probable histidinol Probable (pro-3S)-lyase Rv2277c racemase: far [+ 3 isozymes] (S)-malate AMP ligase: methyladenine stearoyltransferase: dehydrogenase: dehydrogenase: nucleoside 3-cis,cis- (beta subunit): citE glycosylase α papA2 hisD delta7,25-3- [NAD] dependent fadD22 [+ 2 isozymes] -methylacyl-CoA tyrA diphosphate Rv1039c a cis,cis-delta13,25- 4-hydroxybenzoyl-[4- I: tagA kinase: ndkA hydroxyC44:2- malate sn-glycerol racemase: mcr 2-O-sulfo- 3-(4- ModA 3-hydroxyC44:2-[acp] hydroxyphenylalkanoate ser [acyl-carrier oxaloacetate oxidoreductase: mez 3-phosphate an apurinic site 2’-stearoyl- synthase] 3-methyladenine a (2R)-2-methylacyl-CoA hydroxyphenyl) his a nucleoside Rv0590A protein] within DNA α,α-trehalose pyruvate triphosphate dehydratase: pyruvate 3-cis,cis- Amine and Polyamine Degradation hadB hadC Rv3212 delta13,25-3- hydroxyC44:2- Rv2947c 4-aminobutanoate degradation II 3-β- (3S)- [acyl-carrier a 2-methyl branched 2,3,4- glycolaldehyde a trans-delta2-cis,cis- 4-aminobutanoate urea α a proteinogenic hydroxyandrost- 3-methylmuconolactone phenylacetaldehyde hydroxyadipyl- Rv0203 protein] -linolenoyl-CoA a ferrocytochrome b 5 glutathione saturated fatty aldehyde delta7,25-C44:3-[acp] degradation III degradation II amino acid 5-en-17-one CoA dehydratase: aldehyde aldehyde aldehyde 4-aminobutanoate Possible linoleoyl-CoA probable gamma- Possible Rv1354c hadB hadC dehydrogenase: dehydrogenase: dehydrogenase: steroid desaturase (delta(6) glutamyltranspeptidase dehydroepiandrosterone muconolactone 4-aminobutanoate urea Rv0458 Rv0458 enoyl-CoA Rv1841c trans-delta2- 4-aminobutyrate Rv0458 isomerase: -desaturase): desA3 precursor: ggtB dehydrogenase: Rv1106c hydratase: cis,cis- aminotransferase: gabT 4-aminobutyrate urease: an α-(γ-L- Rv0316 a trans-delta2-cis,cis- [+ 4 isozymes] [+ 4 isozymes] [+ 4 isozymes] echA9 delta7,25-C44:3- aminotransferase: ureA a ferricytochrome b stearidonoyl-CoA L-cysteinylglycine glutamyl)-L- Rv3498c delta13,25-C44:3-[acp] succinate semialdehyde 5 5-androstene- a 2-methyl branched 4-methyl-3-oxoadipate- [acp]:NADH+ gabT ureB ureC amino acid phenylacetate glycolate trans-2,3- 3,17-dione 2,3,4-saturated fatty acid enol-lactone Rv3888c oxidoreductase: Inorganic Nutrient Metabolism succinate dehydroadipyl-coA inhA succinate-semialdehyde ammonium Rv1809 trans-delta2- semialdehyde cis,cis- dehydrogenase: gabD1 delta13,25-C44:3- superpathway of sulfate assimilation selenate reduction RNase E mRNA a sophorosyloxyfatty a 1,2-diacyl- Rv0559c a cis,cis-delta7,25-C44:2-[acp] and cysteine biosynthesis Possible succinate- a 5-L-glutamyl- fluoroacetaldehyde [acp]:NADH+ linoleoyl-CoA a ferrocytochrome b an amino acid processing precorrin-6B ser semialdehyde 5 [peptide] acid O(6’’)-acetate sn-glycerol Rv2417c oxidoreductase: substrate 3-phospho- dehydrogenase putative Precorrin-6Y C(5,15) aldehyde Rv1417 inhA selenate succinate Possible linoleoyl-CoA probable gamma- Possible Probable cis,cis-delta7,25- D-glycerate [NADP+] dependent acetyl -methyltransferase dehydrogenase: diacylglycerol desaturase (delta(6) glutamyltranspeptidase ribonuclease L-serine C44:2-[acyl-carrier Probable sulfate (SSDH) GabD2: gabD2 hydrolase (decarboxylating) Rv0458 kinase: Rv2252 -desaturase): desA3 precursor: ggtB E Rne: rne dehydratase: a cis,cis-delta13,25- protein]:malonyl- Possible D-3- adenylyltransferase an α-(5-L- RNase E MbtJ: mbtJ CobL: cobL LprK [+ 4 isozymes] a 1,2-diacyl- sdaA C44:2-[acp] [acyl-carrier protein] phosphoglycerate subunit 2 CysD: cysD a ferricytochrome b γ a peptide glutamyl)- an mRNA fragment processing Rv2401A 5 -linolenoyl-CoA a sophorosyloxyfatty malonyltransferase: dehydrogenase: adenosine 5’- succinate amino acid product mRNA acetate precorrin-8x fluoroacetate sn-glycerol Rv1759c acid pyruvate kasB serA2 phosphoselenate 3-phosphate cis,cis-delta13,25- C44:2-[acyl-carrier protein]:malonyl- [+ 2 isozymes] Probable D-3- Rv1971 thiosulfate disproportionation Rv1995 [acyl-carrier protein] phosphoglycerate a dietary all- (2E,7Z)- a cis,cis-delta9,27- IV (rhodanese) a phenolphthiodiolenone 2-oxoglutarate glyoxylate a phenolic donor GGPP Rv3920c malonyltransferase: dehydrogenase: palmitoyl-CoA a ferrocytochrome b 5 DL-allothreonine trans-retinyl ester tetradecenoyl-CoA kasB 3-oxo-C46:2-[acp] serA1 selenite enoyl-CoA possible Possible linoleoyl-CoA Serine PE-PGRS 2-hydroxy-3- Probable thiosulfate phenolphthiodiolenone hydratase: peroxidase: cis,cis-delta9,27- desaturase (delta(6) hydroxymethyltransferase: family protein, oxoadipate phytoene [+ 2 isozymes] A reductase: Rv2953 echA2 bpoB 3-oxo-C46:2-[acp] sulfate 3-phosphooxypyruvate Probable thiosulfate -desaturase): desA3 glyA2 triacylglycerol synthase: synthase Rv0168 Rv1968 lipase: lipY Rv1248c Rv3169 a cis,cis-delta15,27- reductase: fabG1 sulfurtransferase: cysA2 [+ 18 isozymes] [+ 3 isozymes] PhyA: phyA a ferricytochrome b 5 sapienoyl-CoA gly acetaldehyde 3-oxo-C46:2-[acp] probable: Possible [+ 3 isozymes] a phenolphthiodiolone 2-hydroxy- (S)-3-hydroxy-(7Z) a phenoxyl radical [+ 3 isozymes] selenodiglutathione a fatty acid all-trans-retinol 15-cis-phytoene cysD cysN phosphoserine sulfite thiocyanate 3-oxoadipate -tetradecenoyl-CoA of a phenolic donor cis,cis- a cis,cis-delta9,27-3- aminotransferase: serC LipE Rv3766 delta15,27-3- hydroxyC46:2-[acp] APS Rv2044c oxo-C46:2-[acp] 6 6 RNase III mRNA (3S,6Z,9Z,12Z,15Z,18Z)-3- a [sulfatase]- reductase: fabG1 N ,N -dimethyl- thiosulfate salicylaldehyde 3-phospho- processing a thiol acetaldehyde syringaldazine 3-cis,cis- adenylylsulfate L-arginine hydroxytetracosapentaenoyl-CoA L-cysteine L-serine glutathioselenol substrate [+ 3 isozymes] delta9,27-3- kinase: cysN Formylglycine- probable aldehyde Probable thiosulfate aldehyde N(G),N(G)-dimethylarginine Probable 3-hydroxyacyl-CoA polyphenol Rv1920 hydroxyC46:2- sulfurtransferase: dehydrogenase: dimethylaminohydrolase: ribonuclease dehydrogenase: generating dehydrogenase oxidase: RpfA Rv2028c a cis,cis-delta15,27- [acyl-carrier Phosphoserine/ Rv0458 PAPS Rv2323c III: rnc fadB3 enzyme: (NAD+) cysA2 3-hydroxyC46:2-[acp] threonine Rv2149c protein] RNase III Rv0712 dependent: Rv0147 phosphatase [+ 3 isozymes] [+ 4 isozymes] dehydratase: L-citrulline dimethylamine an mRNA fragment processing (6Z,9Z,12Z,15Z,18Z)-3- tetramethoxy PstP: pstP a [sulfatase]-3- hadB hadC Probable 3’- acetate salicylate azobismethylene 3-cis,cis- hydrogen selenide product mRNA oxotetracosapentaenoyl-CoA a disulfide sulfite phosphoadenosine C1 Compound Utilization and Assimilation oxo-L-alanine quinine Rv0039c [+ 2 isozymes] UvrB delta15,27-3- 5’-phosphosulfate Rv2314c hydroxyC46:2- a trans-delta2-cis,cis- reductase: cysH [acyl-carrier delta9,27-C46:3-[acp] ser formaldehyde oxidation protein] formaldehyde a long-chain VII (THF pathway) sulfite [DNA] 4-hydroxylaminotoluene DMKH 2 benzaldehyde H 2 O betanidin phytenal acyl-CoA dehydratase: sulfite oxidation III formate assimilation into 5,10- Rv0401 trans-delta2- Probable serine Rv3448 hadB hadC phosphate (mycothiol-dependent) methylenetetrahydrofolate ferredoxin- Probable fatty acyl CoA possible aldehyde cis,cis- acetyltransferase: Probable Probable ubiquinone/ probable aldehyde acquisition formaldehyde dependent sulfite exodeoxyribonuclease thioesterase: peroxidase: dehydrogenase: Rv1230c delta9,27-C46:3- cysE hydroxylaminobenzene menaquinone dehydrogenase formaldehyde reductase: sirA III protein: xthA biosynthesis fcoT bpoB Rv0458 a trans-delta2-cis,cis- [acp]:NADH+ formate mutase Hab: hab (NAD+) a phosphate a 2’- methyltransferase: menH dependent: Rv0147 delta15,27-C46:3-[acp] oxidoreductase: an oxidized ferredoxin [+ 2 isozymes] [+ 3 isozymes] [+ 4 isozymes] O-acetyl-L-serine a 5,10- H 2 O hydrogen sulfide deoxyribonucleoside [DNA] 2-amino-5- SppA inhA hydrogen sulfide monoester [iron-sulfur] cluster a long-chain Rv3058c 5’-monophosphate methylphenol MQH 2 benzoate betanidin quinone phytenate acid methylenetetrahydrofolate S-(hydroxymethyl) fatty acid a 10- trans-delta2- phosphatase: mycothiol LpqR formyltetrahydrofolate cis,cis- a cis,cis-delta9,27-C46:2-[acp] Rv2135c methylenetetrahydrofolate delta15,27-C46:3- Cysteine dehydrogenase: folD synthase [+ 3 isozymes] mycothiol- methenyltetrahydrofolate [acp]:NADH+ a 1-long-chain (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3- (11Z)-(S)-3- (2E,9Z)- (indol-3-yl) RplP dependent a long-chain isobutanoate adenosylcobinamide pyrazinamide Rv1196 oxidoreductase: a: cysK1 phosphate a 5,10- cyclohydrolase: folD acyl-glycerone hydroxyhexadec- octadecenoyl-CoA acetamide cis,cis-delta9,27- formaldehyde alcohol hydroxytetracosahexaenoyl-CoA methenyltetrahydrofolate 3-phosphate 11-enoyl-CoA inhA acetyl-coenzyme enoyl-CoA probable probable C46:2-[acyl-carrier dehydrogenase: a 5,10- Possible 3-hydroxyacyl-CoA Rv2672 A synthetase: acs adenosylcobinamide 3-hydroxyacyl-CoA hydratase: amidase: amidase: protein]:malonyl- mscR methenyltetrahydrofolate alkyldihydroxyacetonephosphate dehydrogenase: methenyltetrahydrofolate dehydrogenase: a cis,cis-delta15,27- [acyl-carrier protein] cys synthase: agpS kinase: cobU echA2 amiB2 amiB2 cyclohydrolase: folD fadB3 Rv2508c C46:2-[acp] malonyltransferase: methylenetetrahydrofolate a 1-alkyl- fadB3 Rv3714c S-formylmycothiol a long-chain isobutanoyl-CoA AMP diphosphate [+ 18 isozymes] [+ 4 isozymes] [+ 5 isozymes] kasB dehydrogenase: folD glycerone 3- (6Z,9Z,12Z,15Z,18Z,21Z)-3- adenosyl-cobinamide a 10- fatty acid (11Z)-3-oxo- (S)-3-hydroxy-(9Z) pyrazine-2- phosphate oxotetracosahexaenoyl-CoA phosphate (indol-3-yl)acetate cis,cis-delta15,27- formyltetrahydrofolate hexadecenoyl-CoA -octadecenoyl-CoA carboxylate Rv0851c [+ 2 isozymes] a 5,10- C46:2-[acyl-carrier methylenetetrahydrofolate protein]:malonyl- Probable a cis,cis-delta11,29- Rv2105 Rv2216 [acyl-carrier protein] formyltetrahydrofolate 3-oxo-C48:2-[acp] deformylase: purU α a 1-O-alkyl-2- D-sedoheptulose malonyltransferase: formate -D-galactose 1-phosphate UTP 3,4-dihydroxyphenylacetate a primary alcohol benzaldehyde acetyl-CoA isovalerate O-acyl-3-O-β- 7-phosphate kasB PAPS Rv0822c cis,cis- D-galactosyl- alcohol formate galactose-1-phosphate acetyl-coenzyme Probable catechol-O- Probable aldehyde acetyl-CoA delta11,29-3- sn-glycerol dehydrogenase: [+ 2 isozymes] uridylyltransferase: galTa A synthetase: acs methyltransferase: Glycolipid sedoheptulose- dehydrogenase: carboxylase: Rv2806 Rv0739 oxo-C48:2-[acp] Carbohydrate Degradation sulfotransferase: 7-phosphate adhE1 Rv0458 accE5 reductase: fabG1 galactose-1-phosphate Rv1703c a cis,cis-delta17,29- Rv1373 isomerase: gmhA uridylyltransferase: galTb isovaleryl-CoA AMP diphosphate [+ 5 isozymes] [+ 4 isozymes] [+ 4 isozymes] 3-oxo-C48:2-[acp] [+ 3 isozymes] homovanillate D-glycero-D-manno- D-galactose degradation I (Leloir pathway) UDP-α-D-galactose 3’,5’-ADP a seminolipid an aldehyde benzoate malonyl-CoA LprQ trehalose degradation II (cytosolic) heptose 7-phosphate a cis,cis-delta11,29-3- Rv2041c Rv2168c cis,cis- delta17,29-3- hydroxy C48:2-[acp] β-D-galactopyranose oxo-C48:2-[acp] α α , -trehalose (S)-3- reductase: fabG1 1-chloro-4- a kanamycin (2E,5Z)- 2-methylbutanoate hydroxytetradecanoyl- formaldehyde acrylamide 3-cis,cis- CAIR asp hydroxylaminobenzene dodecenoyl-CoA LpqQ CoA [+ 3 isozymes] delta11,29-3- acetyl-coenzyme Putative enoyl-CoA aldehyde probable Rv2743c Rv3605c Trehalase: Rv2402 Phosphoribosylaminoimidazole- probable hydroxyC48:2- A synthetase: acs 3-hydroxyacyl-CoA aminoglycoside hydratase: dehydrogenase: amidase: a cis,cis-delta17,29- α succinocarboxamide hydroxylaminobenzene [acyl-carrier -D-galactopyranose dehydrogenase: phosphotransferase: echA2 Rv0458 amiB2 3-hydroxyC48:2-[acp] protein] synthase: purC mutase: hab β-D-glucopyranose α-D-glucopyranose fadB3 Rv3168 dehydratase: 2-methylbutanoyl-CoA AMP diphosphate [+ 18 isozymes] [+ 4 isozymes] [+ 4 isozymes] SAICAR 2-amino-5- hadB hadC Probable 3-oxo- a kanamycin (S)-3-hydroxy-(5Z) Rv1906c chlorophenol formate acrylate Rv1257c Rv1382 3-cis,cis- galactokinase: galK myristoyl-CoA 3’-phosphate -dodecenoyl-CoA delta17,29-3- hydroxyC48:2- a trans-delta2-cis,cis- α α [acyl-carrier delta11,29-C48:3-[acp] -D-galactose 1-phosphate UDP- -D-glucose protein] D-glucopyranose D-xylose a single- salicyl-6-hydroxy-2- a 2,3,4-saturated 5-aminolevulinate (S)-lactaldehyde an aldehyde a β-lactam Rv1708 dehydratase: degradation I stranded RNA cyclohexene-on-oyl L-dopa (3S)-3- Rv0507 Rv2253 hadB hadC trans-delta2- hydroxyacyl-CoA Probable acyl-CoA polyribonucleotide Carboxylesterase aldehyde aldehyde β-lactamase: cis,cis- D-xylopyranose ligase: fadD31 nucleotidyltransferase: LipT: lipT Probable catechol-O- 3-hydroxyacyl-CoA dehydrogenase: dehydrogenase: lipL delta11,29-C48:3- gpsI methyltransferase: dehydrogenase: Rv0458 aldA a trans-delta2-cis,cis- [acp]:NADH+ [+ 2 isozymes] β-lactamase: Rv1703c fadB3 delta17,29-C48:3-[acp] oxidoreductase: D-glucopyranose 6-phosphate a nucleoside a single- 6-hydroxy-2- blaC Rv0959 diphosphate AMP 5-aminolevulinyl-CoA [+ 4 isozymes] [+ 4 isozymes] FixA Rv3320c inhA diphosphate stranded RNA salicyl alcohol cyclohexen- a 2,3,4-saturated D-xylulose 3-O-methyldopa a substituted one-carboxylate 3-oxoacyl-CoA (S)-lactate a carboxylate β trans-delta2- -amino acid cis,cis- a cis,cis-delta11,29- probable galactose- Possible delta17,29-C48:3- C48:2-[acp] 1-phosphate D-xylulose Rv2025c Rv1917c [acp]:NADH+ uridylyltransferase: kinase: a double-stranded α sn-glycero-3- a 2’-deoxyribonucleoside O-acetyl-L- 3-[(7’-methylsulfanyl) 5-androstene- Rv0340 oxidoreductase: galTb UDP-galactose 4- 2-O- -mannosyl- xylB [DNA] uroporphyrinogen-I a quinone cis,cis-delta11,29- phosphoethanolamine 5’-triphosphate methanethiol oligonucleotide heptyl]malate 3,17-dione inhA epimerase: galE1 D-glycerate homoserine C48:2-[acyl-carrier glycerolphosphodiesterase: NAD(P)H degradation D-xylulose DNA polymerase III Probable O- Probable probable 3- 5-androstene- protein]:malonyl- probable galactose- [+ 3 isozymes] Rv2277c Oligoribonuclease quinone 5-phosphate (beta chain): dnaN acetylhomoserine uroporphyrinogen isopropylmalate 3,17-dione [acyl-carrier protein] 1-phosphate 2-O-(6-phospho- Orn: orn Rv0538 a cis,cis-delta17,29- [+ 2 isozymes] dehydrogenase: reductase: lpdA isomerase: CinA uridylyltransferase: α-D-mannosyl) [+ 6 isozymes] sulfhydrylase: metC decarboxylase: hemE C48:2-[acp] malonyltransferase: leuB Rv1106c sn-glycerol [+ 2 isozymes] Rv2494 kasB galTa -D-glycerate ethanolamine [DNA] Alpha- 3-phosphate acetate met coproporphyrinogen I a nucleoside 5’- 10-(methylsulfanyl) androst-4-ene- a semiquinone cis,cis-delta17,29- mannosidase: monophosphate -2-oxodecanoate 3,17-dione [+ 2 isozymes] C48:2-[acyl-carrier Rv0648 Rv2337c protein]:malonyl- D-mannose Rv1507c a cis,cis-delta13,31- (R)-glycerate [acyl-carrier protein] degradation 6 2 3-oxo-C50:2-[acp] N -(Δ -isopentenyl) Rv0991c malonyltransferase: a ribonucleoside (2E,6Z,9Z,12Z,15Z,18Z) tuberculosinyl 15-methyl- D-mannopyranose -adenosine 5’- a single stranded DNA an aldehyde baicalein kasB triphosphate -tetracosahexaenoyl-CoA lys acetyl phosphate diphosphate palmitate cis,cis- 6-phosphate monophosphate Probable enoyl-CoA probable aldehyde possible 15-methyl- Rv3413c delta13,31-3- α-D-glucopyranose 1-phosphate UDP-α-D-galactose cytokinin riboside Lysine N- (13R)- Rv1835c [+ 2 isozymes] Probable DNA primase hydratase: echA2 dehydrogenase peroxidase: palmitate ω- oxo-C50:2-[acp] 2-phospho- 5’-monophosphate acetyltransferase isotuberculosinol mannose-6- DnaG: dnaG (NAD+) bpoB hydroxylase: reductase: fabG1 D-glycerate phosphoribohydrolase: log [+ 18 isozymes] MbtK: mbtK synthase: Rv3378c Rv3903c a cis,cis-delta19,31- phosphate 6 dependent: Rv0147 cyp124 phosphoglucomutase: D-ribofuranose ssDNA/pppN(pN) 6 [+ 3 isozymes] 3-oxo-C50:2-[acp] isomerase: N -dimethylallyladenine (3S,6Z,9Z,12Z,15Z,18Z)-3- N -acetyl-L-lysine (13R)- [+ 3 isozymes] pgmA 5-phosphate n -1 hybrid 6,7- 16-hydroxy-15- manA hydroxytetracosapentaenoyl-CoA isotuberculosinol a carboxylate Rv0081 dehydrobaicalein methyl-palmitate trehalose degradation Rv1459c cis,cis- a cis,cis-delta13,31-3- F6P delta19,31-3- hydroxy C50:2-[acp] D-glucopyranose 6-phosphate VI (periplasmic) oxo-C50:2-[acp] Eis 37 a single reductase: fabG1 α,α-trehalose an adenosine tuberculosinyl gentamicin C1a (2E,7Z)- 3-cis,cis- DMAPP 3,4-dihydroxyphenylglycol dopamine acetamide Rv3726 stranded DNA in tRNA diphosphate hexadecenoyl-CoA [+ 3 isozymes] delta13,31-3- RpsS probable Probable tRNA delta(2)- gentamicin 2’-N- possible amidase steroid hydroxyC50:2- Probable catechol-O- Probable catechol-O- (13S)- Trehalase: Rv2402 exodeoxyribonuclease isopentenylpyrophosphate acetyltransferase: (aminohydrolase) enoyl-CoA a cis,cis-delta19,31- [acyl-carrier methyltransferase: methyltransferase: isotuberculosinol VII: xseB xseA transferase: miaA aac : Rv3175 hydratase: Rv2401 3-hydroxyC50:2-[acp] protein] 6 37 Rv1703c Rv1703c synthase: Rv3378c dehydratase: a single-stranded a ribonucleoside N -dimethylallyladenosine echA9 α β N2’- [+ 4 isozymes] Rv0036c -D-glucopyranose -D-glucopyranose 3-methoxy-4- (13S)- hadB hadC oligodeoxyribonucleotide 5’-monophosphate in tRNA 3-methoxytyramine acetylgentamicin (S)-3-hydroxy-(7Z) LprG 3-cis,cis- hydroxyphenylglycol isotuberculosinol acetate C 1A -hexadecenoyl-CoA delta19,31-3- hydroxyC50:2- a trans-delta2-cis,cis- Rv1243c [acyl-carrier delta13,31-C50:3-[acp] 6 Rv3300c protein] an O - an N-hydroxy- (2E,9Z)- a [protein]- α a cutin TrxC dehydratase: methylguanine UDP- -D-glucose a dolichyl phosphate a PII protein UTP an acyl phosphate (+)-muconolactone L-cysteine arylamine hexadecenoyl-CoA hadB hadC trans-delta2- in DNA Probable cis,cis- Methylated-DNA- dolichyl- Probable [protein-PII] Possible steroid Arylamine N- Probable cutinase delta31,13-C50:3- -protein-cysteine phosphate sugar uridylyltransferase: muconolactone enoyl-CoA Rv1195 acetyltransferase: nat acylphosphatase: [acp]:NADH+ synthase: Rv0539 isomerase: Cut1: cut1 hydratase: Rv1095 a trans-delta2-cis,cis- methyltransferase: ogt glnD acyP oxidoreductase: β Rv0316 echA9 Rv3539 delta19,31-C50:3-[acp] a [protein]-S- a dolichyl -D- a uridylylated [+ 6 isozymes] inhA a guanine in DNA UDP an N- methyl-L-cysteine glucosyl phosphate PII protein (4,5-dihydro-5- (S)-3-hydroxy-(9Z) acetoxyarylamine a carboxylate a cutin monomer trans-delta2- oxofuran-2-yl)-acetate -hexadecenoyl-CoA cis,cis- a cis,cis-delta13,31- Rv2536 Rv2634c delta19,31-C50:3- C50:2-[acp] Rv1674c [acp]:NADH+ a 2,3,4-saturated 1,2-diacyl- UDP-N-acetyl- (2E,6Z,9Z,12Z,15Z,18Z,21Z) 3-amino-4- α,α-trehalose (2E,11Z)- oxidoreductase: CTP benzyl alcohol coniferyl alcohol cis,cis-delta13,31- α a dolichyl phosphate -tetracosaheptaenoyl-CoA hydroxybenzoate octadecenoyl-CoA inhA sn-glycerol 3-phosphate -D-glucosamine C50:2-[acyl-carrier Probable integral enoyl-CoA palmitoyl-CoA- Probable NADP- possible steroid protein]:malonyl- dolichyl- Rv3236c Arylamine N- -trehalose dependent alcohol peroxidase: Rv1113 membrane phosphatidate phosphate sugar hydratase: echA2 enoyl-CoA AprC a cis,cis-delta19,31- [acyl-carrier protein] palmitoyltransferase: bpoB cytidylyltransferase: cdsA synthase: Rv0539 acetyltransferase: nat dehydrogenase hydratase: C50:2-[acp] malonyltransferase: [+ 18 isozymes] α papA3 AdhC: adhC echA9 kasB a dolichyl N-acetyl- -D- [+ 3 isozymes] a CDP-2,3,4-saturated-diacylglycerol UDP (3S,6Z,9Z,12Z,15Z,18Z,21Z)-3- 3-acetylamino-4- 2-palmitoyl- cyclopropane glucosaminyl phosphate coniferyl (S)-3-hydroxy-(11Z) hydroxytetracosahexaenoyl-CoA hydroxybenzoate trehalose benzaldehyde -octadecenoyl-CoA Rv1002c synthase: pcaA [+ 2 isozymes] alcohol radical Rv3099c Rv1067c C52-α-meroacyl- a cis,cis-delta15,33- [acp] synthase: 3-oxo-C52:2-[acp] trans-zeatin riboside α,α-trehalose mmaA2 3,4-dihydroxymandelate HMP-P MeOH hispidin oxalyl-CoA monophosphate a D-aminoacyl-[tRNA] Rv1706c cis,cis- cytokinin riboside stearoyl-CoA- Probable NADP- possible Probable HflX a C52-α-meroacyl-[acp] delta15,33-3- Probable catechol-O- Probable EsxW D-aminoacyl-tRNA -trehalose peroxidase: oxo-C52:2-[acp] 5’-monophosphate methyltransferase: phosphomethylpyrimidine dependent alcohol oxalyl-CoA deacylase: dtd stearoyltransferase: bpoB reductase: fabG1 phosphoribohydrolase: log Rv1703c kinase: thiD dehydrogenase decarboxylase α papA3 AdhC: adhC OxcA: oxcA C52- - D-ribofuranose an uncharged tRNA a D-amino acid [+ 3 isozymes] Rv2054 trans-zeatin 2-stearoyl- meroacyl-AMP [+ 3 isozymes] 5-phosphate vanillyl mandelate HMP-PP ligase: fadD32 trehalose formaldehyde 3,14’-bihispidinyl formyl-CoA Rv3426 a cis,cis-delta15,33-3- EsxT hydroxy C52:2-[acp] a C52-α-meroacyl-adenylate

Rv3850 3-amino-4- C31- 5-chloro-5- 3-cis,cis- (11Z)-3-oxo-hexadecenoyl-CoA 3-oxo-(9Z)-hexadecenoyl-CoA O-succinyl-L- a phenolphthiotriol a cis-2-enoyl-CoA α-meroacyl-AMP:2- hydroxybenzaldehyde methanethiol phthiodiolenone A deoxy-D-ribonate Rv3739c delta15,33-3- homoserine carboxyl-cerotoyl-CoA Probable beta-ketoacyl probable beta-ketoacyl Rv0477 hydroxyC52:2- cystathionine C31- Probable steroid 4’-phosphopentetheinyl CoA thiolase FadA3: fadA3 CoA thiolase: fadA3 phenolphthiotriol [acyl-carrier Arylamine N- phthiodiolenone dihydroxy-acid enoyl-CoA transferase gamma- methyltransferase: protein] [+ 2 isozymes] acetyltransferase: nat A reductase: dehydratase: hydratase: Rv0907 [+ 2 isozymes] synthase: metB Rv2952 dehydratase: Rv2953 ilvD echA9 (9Z)-tetradecenoyl-CoA Rv2629 a 3-oxo-C78-α- acetyl-CoA (7Z)-tetradecenoyl-CoA acetyl-CoA 3-acetylamino-4- succinate met hadB hadC a phenolphthiocerol C31- 5-chloro-4-hydroxy- a (3R)-3- mycolate-[pks13] hydroxybenzaldehyde phthiodiolone A 2-oxopentanoate hydroxyacyl-CoA EsxS

3-oxo-C78-α- a trans-delta2-cis,cis- Rv2366c mycolate-[pks13] delta15,33-C52:3-[acp] Rv3660c reductase: 4-methyl-5-(2- (2R,3S)-3- 3-oxo-(7Z)-hexadecenoyl-CoA cis-vaccenyl acetate (R)-noradrenaline (R)-adrenaline a steryl-ester pyruvate Rv2509 phosphooxyethyl) HMP-PP isopropylmalate trans-delta2- Rv3725 carboxylesterase: lipN thiazole cis,cis- probable beta-ketoacyl Thiamine-phosphate Probable catechol-O- Probable catechol-O- PE-PGRS probable 3- Probable Rv2709 delta15,33-C52:3- CoA thiolase: fadA3 carboxylesterase: lipL family protein, isopropylmalate pyruvate a C78-α-mycolate-[pks13] pyrophosphorylase: methyltransferase: methyltransferase: [acp]:NADH+ dehydratase: [+ 2 isozymes] [+ 4 isozymes] thiE Rv1703c Rv1703c triacylglycerol carboxylase: RplD oxidoreductase: lipase: lipY leuD leuC pca thiamine α inhA acetyl-CoA (5Z)-tetradecenoyl-CoA acetate cis-vaccenyl alcohol C78- -mycolate- phosphate normetanephrine metanephrine (2S)-2- a sterol a fatty acid oxaloacetate RtcB [pks13-c-ppb] isopropylmalate HbhA mycolyltransferase: a cis,cis-delta15,33- Rv3802c C52:2-[acp] GlbO 6-O-mycolyl-β-D- S-(4-hydroxy- an α-D-mannoside 2-methyl-1,4- mannopyranosyl-1- 3-oxo-(9Z)-octadecenoyl-CoA PAPS a digalactosylceramide an arylamine an alcohol veratryl alcohol cis,cis-delta15,33- nonenal-3-yl)-L- benzoquinone Rv1818c phosphoheptaprenol cysteinylglycine Rv0446c C52:2-[acyl-carrier probable beta-ketoacyl Alpha- glycolipid Probable Probable NADP- Probable Probable protein]:malonyl- CoA thiolase: fadA3 mannosidase: sulfotransferase: Arylamine N- 6-O-mycolyl-β-D-mannopyranosyl- aminopeptidase dependent alcohol NADPH quinone lignin MbtM [acyl-carrier protein] Rv0648 Rv1373 acetyltransferase: nat 1-phosphoheptaprenol:trehalose [+ 2 isozymes] dehydrogenase oxidoreductase: peroxidase malonyltransferase: N: pepN 6-phosphate a non glycosylated α-D- a digalactosylceramide S-(4-hydroxy- AdhC: adhC fadB4 LipJ: lipJ kasB acetyl-CoA (7Z)-hexadecenoyl-CoA 3’,5’-ADP sugar acceptor mannopyranose an N- gly nonenal-3- Rv2229c mycolyltransferase: lpqX sulfate methyl-1,4- veratryl Rv0627 acetylarylamine yl)-L-cysteine an aldehyde [+ 2 isozymes] benzoquinol alcohol radical 6-O-α-mycolyl- RpsO trehalose 6-phosphate a cis,cis-delta17,35- 3-oxo-C54:2-[acp] + (5Z,8Z,11Z,14Z,17Z) a DNA containing a double (2R,3S)-3- Rv3631 Trehalose 6- palmitoleoyl-CoA (S)-methylmalonyl-CoA NADPH H coenzyme A O-phospho- 3-ethylmalate an oxidized flavin Rv3897c -icosapentaenoate an apurinic/ stranded DNA cys isopropylmalate phosphate L-homoserine cis,cis- acyl-CoA apyrimidinic site Rv0205 phosphatase: 2-methyl-octadec-2,9- Probable 3- Probable 3- flavin delta17,35-3- synthetase: fadD32 Probable probable cystathionine dienoate synthase: isopropylmalate isopropylmalate reductase otsB2 oxo-C54:2-[acp] endonuclease exonuclease: gamma- pks17 pks8 dehydrogenase: dehydrogenase: (NADH) reductase: fabG1 [+ 21 isozymes] III: nth recD recB recC synthase: metB Rv0284 [+ 2 isozymes] (5Z,8Z,11Z,14Z,17Z) leuB leuB : hsaB 2-methyl-octadec-2,9-dienoate a 3’-terminal a 5’-phospho- EspB [+ 3 isozymes] -icosapentaenoyl-CoA unsaturated sugar [DNA] a 5’-phosphooligonucleotide L-cystathionine 4-methyl-2- α α α 2-oxovalerate a reduced flavin Rv1624c , ’-trehalose 6- -mycolate oxopentanoate a cis,cis-delta17,35- 3-hydroxyC54:2-[acp] trehalose- Rv0625c mono-mycolate β a -D-galactosyl-N a single D-sedoheptulose phosphoenol Rv2004c transporter: methylmalonate semialdehyde GSSH sulfite PAPS orcinol (S)-malate 3-cis,cis- -acylsphingosine stranded DNA 1-phosphate pyruvate LpqY Rv1273c delta17,35-3- probable thiosulfate glycolipid Probable methylmalonate- Probable catechol-O- probable Probable Probable hydroxyC54:2- sulfurtransferase: cysA2 Probable semialdehyde sulfotransferase: fructose- malate:quinone pyruvate EspK α α α [acyl-carrier methyltransferase: endonuclease , ’-trehalose 6- -mycolate dehydrogenase: mmsA Rv1373 protein] [+ 3 isozymes] Rv1703c IV: end bisphosphate oxidoreductase: kinase + dehydratase: a galactosylceramide aldolase: fba mqo PykA: pykA LppC Rv1269c H NADH hydrogencarbonate propanoyl-CoA thiosulfate glutathione 3’,5’-ADP 3-methoxy-5- hadB hadC sulfate a 5’-phosphooligonucleotide DHAP oxaloacetate pyruvate α,α-trehalose- arabinogalactan: hydroxytoluene D-erythrose α α Rv2769c 6-mycolate: , - trehalose- trehalose-6-mycolate mono-mycolate a trans-delta2-cis,cis- delta17,35-C54:3-[acp] 6-mycolyltransferase: mycolyltransferase: Rv3705A Rv3425 fbpB fbpB 5,10-methylene- 3-methyl-2- cholest-4- pregn-5-ene- a carboxylic ester [DNA] F6P 2-hydroxyisobutyramide β tetrahydromethanopterin oxobutanoate -alanine en-3-one 3,20-dione trans-delta2- carboxylesterase: lipL EmbR 3-methyl-2-oxobutanoate Putative pre-16S cholest-4- α,α-trehalose- arabinogalactan: cis,cis- probable preg-5-en- hydroxymethyltransferase carboxylesterase: lipN rRNA nuclease: 6-phosphofructokinase: 4-aminobutyrate en-3-one 1- 6-mycolate:α,α- trehalose- delta17,35-C54:3- amidase: amiB2 3,20-dione PanB: panB Rv2554c pfkB aminotransferase: dehydrogenase: trehalose-6-mycolate mono-mycolate [acp]:NADH+ [+ 3 isozymes] isomerase: Rv2226 [+ 4 isozymes] gabT kstD Rv1157c 6-mycolyltransferase: mycolyltransferase: oxidoreductase: a 2’-deoxyribonucleoside Rv1106c THMPT 2-dehydropantoate a carboxylate an alcohol [DNA] β-D-fructose 1,6- 2-hydroxy-2- fbpA fbpA inhA 5’-monophosphate cholest- Rv0517 bisphosphate methylpropanoate 3-oxopropanoate progesterone dien-3-one a cis,cis-delta17,35- α,α-trehalose- arabinogalactan: Rv1453 C54:2-[acp] 6-mycolate:α,α- trehalose- trehalose-6-mycolate mono-mycolate a 10- a [protein]- RNase G dTDP-viosamine benzylbenzoate α-D- a D-tryptophanyl- Rv2305 glutathione glycyl-glycine Trp L-tyrosine degradation (R)-NADPHX 6-mycolyltransferase: mycolyltransferase: cis,cis-delta17,35- formyltetrahydrofolate glucopyranose ATP [tRNA ] phosphate substrate mRNA fbpC fbpC C54:2-[acyl-carrier dTDP-viosamine N probable gamma- carboxylesterase: lipN 1-phosphate D-aminoacyl- NAD(P)H- protein]:malonyl- -formyltransferase: glutamyltranspeptidase carboxylesterase: lipL Phosphotyrosine Possible MtrA glucose-1-phosphate tRNA hydrate [acyl-carrier protein] Rv3404c precursor: ggtB protein ribonuclease [+ 3 isozymes] adenylyltransferase: deacylase: dtd epimerase: α α malonyltransferase: phosphatase: ptpA E Rne: rne , ’-trehalose α,α-trehalose a mycolyl-arabinogalactan- dTDP-4-formamido-4,6- γ Trp nnr Rv0795 -L-glutamyl- glgC 6,6’-bismycolate peptidoglycan complex kasB a tetrahydrofolate α L-cysteinylglycine benzyl alcohol benzoate a tRNA dideoxy- -D-glucose glycylglycine ADP-α-D-glucose D-tryptophan a [protein]- an mRNA fragment (S)-NADPHX L-tyrosine [+ 2 isozymes] ClpC

a cis,cis-delta19,37- BlaR 3-oxo-C56:2-[acp] 13-sophorosyloxydocosanoate UDP-N-acetyl- RNase E a supercoiled 4-guanidinobutyramide Ins(2)P 6’,6’’-diacetate α-D-glucosamine a dolichyl phosphate a tRNA precursor H 2 O diphosphate degradation duplex DNA cis,cis-delta19,37- putative acetyl substrate mRNA PlsC dolichyl- Inorganic probable DNA 3-oxo-C56:2-[acyl- hydrolase MbtJ: mbtJ tRNase probable inositol- Possible pyrophosphatase: amidase: amiB2 helicase carrier protein] phosphate sugar Z: rnz monophosphatase: Rv3278c 13-[O(2’)-β-D-glucopyranosyl-β-D- ribonuclease Ercc3: synthase: Rv0539 ppa impA reductase: fabG1 acetate glucopyranosyloxy]docosanoate a single-stranded [+ 4 isozymes] E Rne: rne N-acetyl-α-D-glucosaminyl- mature tRNA + ercc3 O(6’’)-acetate UMP oligoribonucleotide phosphate H [+ 3 isozymes] diphosphodolichol 4-guanidinobutanoate a single myo-inositol an mRNA fragment Rv1358 stranded DNA a cis,cis-delta19,37-3- Rv0699 hydroxy-C56:2-[acp]

an aryl dialkyl an (L-cysteinylglycine) a [protein]- a 1,4-α-D-glucan maltose 3-cis,cis- amino-parathion succinyl-CoA acetoacetate an acetyl ester phosphate -S-conjugate L-histidine EspI delta19,37-3- Probable probable succinyl-CoA:3- carboxylesterase: lipN Probable 1,4-alpha- Probable hydroxyC56:2- Probable histidine Rv1763 phosphotriesterase: php ketoacid-coenzyme A carboxylesterase: lipL aminopeptidase glucan alpha- [acyl-carrier phosphotriesterase: methyltransferase: transferase: scoB scoA N: pepN branching glucosidase: protein] [+ 4 isozymes] php egtD 4-aminophenol diethylthiophosphate τ enzyme: glgB aglA dehydratase: a dialkyl an L-cysteine- acetoacetyl-CoA succinate acetate an alcohol a phenol gly a [protein] N - α Rv0577 hadB hadC phosphate S-conjugate a (1,6)- -D-glucosyl- methyl-histidine α D-glucopyranose Rv2113 (1,4)- -glucan

a trans-delta2-cis,cis- delta19,37-C56:3-[acp] a deaminated an all-trans a [protein]- an organic Ala Rv0901 methyl parathion cadaverine a peptide with a a catechol an aryl sulfate amino group donor -retinyl ester L-cysteine hydroperoxide a glycyl-[tRNA ] Rv0996 leader sequence trans-delta2- Probable Probable L- Carboxylesterase Probable Probable signal Probable catechol-O- D-aminoacyl- arylsulfatase: cis,cis- phosphotriesterase: php lysine-epsilon LipT: lipT peroxiredoxin peptidase I: lepB methyltransferase: tRNA atsB delta19,37-C56:3- aminotransferase: lat AhpE: ahpE [+ 2 isozymes] Rv1703c deacylase: dtd [acp]:NADH+ dimethylthiophosphate 4-nitrophenol a [protein] [+ 3 isozymes] SigA an aminated amino a peptide Ala oxidoreductase: 1-piperideine a fatty acid all-trans-retinol a leader sequence group donor an alcohol carrying a a tRNA gly Rv2437 inhA disulfide bond a guaiacol a phenol

a cis,cis-delta19- Rv1200 37-C56:2-[acp] + γ-glutamyl-p- 7,8- α a monocarboxylic a damaged heptanoyl-CoA malonyl-CoA (S)-methylmalonyl-CoA NADPH H glycyl-glycine an -limit dextrin a mycothiol S-conjugate testosterone Rv2405 nitroanilide dihydromonapterin acid amide DNA pyrimidine C32-mycoketide- probable gamma- Probable mycothiol S Probable 4-alpha- 3 β-hydroxysteroid amidase: Possible DNA cis-delta19-37- CoA synthase: pks12 glutamyltranspeptidase dihydroneopterin -conjugate cis,cis-delta19-37- glucanotransferase: dehydrogenase: amiC glycosylase: hydroxy-38- C56:2-[acyl-carrier precursor: ggtB aldolase: folB malQ amidase: mca Rv0074 C32-mycoketide-CoA Rv1106c [+ 4 isozymes] Rv2464c methyl-C57:1- protein]:malonyl- γ-L-glutamyl- 6-(hydroxymethyl) Rv0187 4-nitroaniline a α-limit dextrin [acp] synthase: glycolaldehyde a mercapturate GlcN-Ins androst-4-ene- an apyrimidinic [acyl-carrier protein] glycylglycine -7,8-dihydropterin with short branches a monocarboxylate mmaA4 malonyltransferase: 3,17-dione site in DNA kasB Rv1877

Rv0514 a cis-delta19-37-hydroxy- [+ 2 isozymes] a generic a 1-acyl-sn-glycero- + a peptide with D-gluconate ammonium NAD(P) H 2 O testosterone (S)-NADPHX citrate 38-methyl-C57:1-[acp] polynucleotide substrate 3-phosphocholine an N-terminal 6-phosphate nuclease: Possible probable nitrite L-proline a cis,cis-delta21,39- probable 6- 3 β-hydroxysteroid ADP-dependent spmT lysophospholipase: reductase [NAD(P) Probable proline aconitase: 3-oxo-C58:2-[acp] phosphogluconate dehydrogenase: NAD(P)H-hydrate Rv2219A cis-methoxy-C59- Rv0183 H]: nirB nirD iminopeptidase: pip acn Rv3031 trans-delta18- a 5’-phosphooligonucleotide a 5’-phosphomononucleotide dehydrogenase: gnd1 Rv1106c dehydratase: nnr 37-hydroxy-38- meroacyl-[acp] sn-glycero-3- cis,cis-delta21,39- a carboxylate nitrite a peptide pro synthase: mmaA3 phosphocholine D-ribulose androst-4-ene- methyl-C58:1- 3-oxoC58:2-[acp] NADPH D-threo-isocitrate 5-phosphate 3,17-dione [acp] synthase: reductase: fabG1 mmaA1 Rv2204c LprI a cis-delta19-37-methoxy- [+ 3 isozymes] 38-methyl-C57:1-[acp] 1-(oleoyl)-sn-glycero-3- a [protein] carrying methyl (indol- D-gluconate a double a cis,cis-delta21,39- quercetin glutathione asp a 3-oxosteroid a trans-delta18-37-hydroxy- phosphoethanolamine a disulfide bond 3-yl)acetate 6-phosphate a D-aspartyl-[tRNA ] stranded DNA cis-methoxy-C59- 3-hydroxyC58:2-[acp] 20,38-dimethyl-C58:1-[acp] quercetin 2,3- Possible possible Carboxylesterase meroacyl-[acp] probable 6- D-aminoacyl- 3-oxosteroid 1- DNA RplS dioxygenase: Rv0181c lysophospholipase: glutaredoxin LipT: lipT Rv2623 synthase: mmaA2 3-cis-delta21,39- phosphogluconate tRNA dehydrogenase: gyrase: trans-methoxy- Rv0183 protein: Rv3198A [+ 2 isozymes] dehydrogenase: gnd1 3-hydroxyC58:2- CO 2-protocatechuoylphloroglucinolcarboxylate deacylase: dtd kstD gyrB gyrA C60-meroacyl- [+ 2 isozymes] sn-glycero-3- a [protein] with reduced [acyl-carrier oleate GSSG MeOH (indol-3-yl)acetate asp [acp] synthase: phosphoethanolamine L-cysteine residues D-ribulose tRNA D-aspartate a 3-oxo- a negatively protein] 1 a cis-methoxy- 5-phosphate D mmaA3 -steroid supercoiled DNA LprH C59-meroacyl-[acp] dehydratase: Rv3685c hadB hadC a trans-delta18-37-methoxy- cis-methoxy-C59- 20,38-dimethyl-C58:1-[acp] a long-linear + + 5-amino-4- α Tyr meroacyl-AMP a trans-delta2-cis,cis- PRPP α -D-glucopyranose palmitoyl-CoA NADH H hydrogencarbonate H C31-phthiotriol phytanate cholesterol imidazolecarboxyamide -D-glucan a D-tyrosyl-[tRNA ] ligase: fadD32 delta21,39-C58:3-[acp] trans-methoxy- Rv2480c Adenine Probable 4-alpha- Possible fatty Beta-carbonic C31-phthiotriol Rv1842c D-aminoacyl- phytanate ω- cholesterol C60-meroacyl- a cis-methoxy-C59- phosphoribosyltransferase: apt glucanotransferase: acyl-CoA anhydrase: canA methyltransferase: tRNA hydroxylase: oxidase: [acp] synthetase: trans-delta2- malQ meroacyl-adenylate reductase: Rv1543 [+ 2 isozymes] Rv2952 cmaA2 cis,cis- AICAR deacylase: dtd cyp124 choD Tyr delta21,39-C58:3- a short glucan palmitaldehyde H 2 O CO 2 a tRNA D-tyrosine cholest-4- [acp]:NADH+ C32-phthiocerol A 16-hydroxyphytanate Rv0278c a trans-methoxy- en-3-one Rv1072 C60-meroacyl-[acp] oxidoreductase: inhA

+ a plant soluble (-)-methyl S-(3-methylbutan- a negatively acetyl-CoA malonyl-CoA NADPH H D-glucopyranose a monoamine a cerebroside PAPS 2’-deoxyribose trans-methoxy- a cis,cis-delta21,39- heteroglycan jasmonate 3-yl)-L- supercoiled DNA Rv1339 Rv3243c C60-meroacyl- C58:2-[acp] fatty acid Probable 4-alpha- flavin-containing Carboxylesterase Glycolipid cysteinylglycine AMP ligase: Probable DNA synthase: fas glucanotransferase: monoamine LipT: lipT sulfotransferase: Ribokinase fadD32 2-carboxy-cerotoyl-CoA aminopeptidase topoisomerase cis-delta21-39- malQ oxidase: aofH Rv1373 RbsK: rbsK [+ 2 isozymes] N: pepN I: topA hydroxy-40- a long-chain fatty acid a plant soluble maltose methyl-C59:1- a primary amine an aldehyde MeOH (-)-jasmonate a sulfatide 2-deoxy-D-ribose Rv0590 heteroglycan 3’,5’-ADP gly felinine PrcA a trans-methoxy-C60- [acp] synthase: a relaxed DNA 5-phosphate cis-methoxy-meroacyl- meroacyl-adenylate mmaA4 AMP:2-carboxyl- cerotoyl-CoA 4’- phosphopentetheinyl a cis-delta21-39-hydroxy- β β trans-methoxy- + 13-[O(2’)- -D-glucopyranosyl- -D- transferase 40-methyl-C59:1-[acp] acetyl-CoA malonyl-CoA NADPH H palmitoyl-CoA H 2 O stearoyl-CoA H 2 O a phthiotriol pregnenolone D-ribofuranose RpfD Rv2091c meroacyl-AMP:2- glucopyranosyloxy]docosanoate MEP CTP O(6’’)-acetate carboxyl-cerotoyl-CoA fatty acid fatty acyl CoA fatty acyl CoA putative acetyl 4-diphosphocytidyl- phthiotriol pregnenolone 4’-phosphopentetheinyl synthase: Rv3720 thioesterase: fcoT thioesterase: fcoT Ribokinase hydrolase MbtJ: mbtJ 2C-methyl-D-erythritol methyltransferase: dehydrogenase: transferase a 3-oxo-C85-cis- trans-delta20- cis-delta21- RbsK: rbsK [+ 2 isozymes] [+ 2 isozymes] methoxy-mycolate-[pks13] 39-hydroxy-40- a long-chain acyl-CoA synthase: ispD Rv2952 Rv1106c 39-hydroxy- acetate sophorosyloxydocosanoate 4-(cytidine 5’-diphospho) CcdA Rv2449c methyl-C60:1- palmitate stearate D-ribofuranose 40-methyl- -2-C-methyl-D-erythritol pregn-5-ene- [acp] synthase: a phthiocerol 5-phosphate a 3-oxo-C86-trans- 3-oxo-C85- C59:1-[acp] 3,20-dione mmaA1 methoxy-mycolate-[pks13] cis-methoxy- oxidoreductase: mycolate-[pks13] Rv0161 reductase: Rv2326c Rv3873 3-oxo-C86- 1-(3,4-dimethoxyphenyl)-2-(2- β-D-fructofuranose all-trans- Rv2509 a glucan maltotriose a folate (S)-NADHX hyaluronan trans-methoxy- a trans-delta20-39-hydroxy- methoxyphenoxy)propane-1,3-diol asp fumarate 1-phosphate retinyl palmitate 40-methyl-C60:1-[acp] mycolate-[pks13] a cis-delta21-39-oxo- Probable lignin Probable 4-alpha- Probable fructose- Carboxylesterase Probable L-aspartate ADP-dependent reductase: a C85-cis-methoxy- 40-methyl-C59:1-[acp] peroxidase LipJ: lipJ glucanotransferase: bisphosphate LipT: lipT dihydrofolate hyaluronidase: oxidase NadB: nadB NAD(P)H-hydrate Rv2509 mycolate-[pks13] malQ aldolase Fba: fba Rv0394c trans-delta20- [+ 2 isozymes] reductase: dfrA HtpG Rv0199 glycolaldehyde guaiacol veratraldehyde dehydratase: nnr 39-hydroxy- cis-keto-C60- succinate 2-iminosuccinate D-glucopyranose a glucan D-glyceraldehyde DHAP a C86-trans-methoxy- C85-cis-methoxy- 40-methyl- meroacyl-[acp] palmitate a retinol hyaluronate a 7,8-dihydrofolate NADH mycolate-[pks13] mycolate- C60:1-[acp] synthase: mmaA2 [pks13-c-ppb] oxidoreductase: [+ 2 isozymes] mycolyltransferase: Rv0161 C86-trans- Rv2620c Rv0169 Rv3802c methoxy-mycolate- a cis-keto-C60-meroacyl-[acp] + + 7,8-dihydrofolate + a primary alkyl (indol-3- a plastoquinone NAD(P)H H palmitoyl-CoA NADPH H NADPH H 2-oxoglutarate oleoyl-CoA H 2 O a phthiotriol a chitodextrin [pks13-c-ppb] 6-O-cis-methoxy-mycolyl- a trans-delta20-39-oxo- monoglutamate sulfate ester yl)pyruvate mycolyltransferase: β -D-mannopyranosyl- 40-methyl-C60:1-[acp] Probable NADPH quinone Possible fatty acyl-CoA dihydrofolate alkyl fatty acyl CoA Rv3802c cis-keto-C60- indole-3-pyruvate phthiodiolone possible 1-phosphoheptaprenol oxidoreductase: fadB4 reductase: Rv1543 reductase: dfrA sulfatase: thioesterase: fcoT Rv3776 meroacyl-AMP decarboxylase: ketoreductase: chitinase: LipB trans-keto-C61- + + Rv3406 6-O-trans-methoxy-mycolyl- 5,6,7,8- [+ 2 isozymes] pdc Rv2951c Rv1987 6-O-cis-methoxy-mycolyl- meroacyl-[acp] ligase: fadD32 NAD(P) a plastoquinol palmitaldehyde NADP β-D-mannopyranosyl- tetrahydrofolate β-D-mannopyranosyl-1- succinate an aldehyde oleate N,N’- 1-phosphoheptaprenol synthetase: (indol-3-yl) a cis-keto-C60- a phthiodiolone diacetylchitobiose phosphoheptaprenol:trehalose cmaA2 acetaldehyde 6-phosphate meroacyl-adenylate 6-O-trans-methoxy-mycolyl- Rv3026c mycolyltransferase: lpqX Rv1463 β-D-mannopyranosyl-1- a trans-keto-C61- meroacyl-[acp] cis-keto-meroacyl- phosphoheptaprenol:trehalose CTP AMP:2-carboxyl- D-glucopyranose 6-phosphate 6-O-cis-methoxy-mycolyl- maltopentaose 2-oxoglutarate a sphingomyelin a 9S rRNA methylsalicylate a phthiodiolenone propionamide cerotoyl-CoA 4’- mycolyltransferase: lpqX trehalose 6-phosphate trans-keto-C61- Probable phosphopentetheinyl Probable 4-alpha- dihydrolipoamide sphingomyelinase: Possible Carboxylesterase RplI meroacyl-AMP phthiodiolenon probable deoxycytidine Rv2169c transferase glucanotransferase: malQ dehydrogenase: lpdC spmT LipT: lipT ligase: fadD32 ribonuclease amidase: amiB2 6-O-trans-methoxy-mycolyl- Trehalose 6- reductase: triphosphate maltose maltotetraose E Rne: rne [+ 2 isozymes] trehalose 6-phosphate phosphate NADH CO 2 succinyl-CoA phosphocholine a ceramide Rv2953 [+ 4 isozymes] deaminase: dcd a trans-keto-C61- phosphatase: a 3-oxo-C86-cis- an rRNA fragment a 5S rRNA MeOH salicylate otsB2 meroacyl-adenylate keto-mycolate-[pks13] a phthiodiolone propanoate UTP Trehalose 6- Rv2235 FtsW phosphate [+ 2 isozymes] trans-keto-meroacyl- phosphatase: 3-oxo-C86-cis- AMP:2-carboxyl- otsB2 trehalose-cis-methoxy- keto-mycolate- cerotoyl-CoA 4’- α α α mono-mycolate [pks13] maltohexaose maltose (4-hydroxyphenyl) 4 ,14 -dimethyl-5 - a sophorosyloxyfatty 24,25- a 1,2-diacyl- hydrogen phosphopentetheinyl β SAICAR A(H2) [+ 2 isozymes] reductase: acetate cholesta-8,24-dien-3 -ol acid 6’,6’’-diacetate dihydrolanosterol sn-glycerol peroxide UsfY transferase Probable 4-alpha- Rv0291 trehalose-trans- trehalose- Rv2509 4-hydroxyphenylacetate Cytochrome putative acetyl Probable Cytochrome triacylglycerol catalase- glucanotransferase: malQ methoxy-mono-mycolate cis-methoxy- hydrolase: lipN P450 51: cyp51 hydrolase adenylosuccinate P450 51: synthase: tgs1 peroxidase: mono-mycolate a 3-oxo-C87-trans- a C86-cis-keto- D-glucopyranose maltoheptaose 4α-methyl-5α-cholesta- MbtJ: mbtJ lyase: purB cyp51 katG transporter: acetate hydroquinone formate β 4,4-dimethyl- [+ 14 isozymes] trehalose- keto-mycolate-[pks13] mycolate-[pks13] 8,14,24-trien-3 -ol a sophorosyloxyfatty acetate AICAR fumarate α H 2 O A Rv1273c acid O(6’’)-acetate formate 5- -cholesta- a triacyl-sn Rv3635 trans-methoxy- Rv2823c 8,14-dien-3-β-ol -glycerol mono-mycolate 3-oxo-C87-trans- C86-cis-keto-mycolate- trehalose-cis-methoxy- transporter: keto-mycolate- [pks13-c-ppb] mono-mycolate Rv1273c [pks13] mycolyltransferase: reductase: Rv3802c β sec maltohexaose D-glucopyranose a -D glucoside maltohexaose citrate a 14α-methylsteroid lanosterol Rv1790 trehalose-trans- Rv2509 a tRNA ser β salicylate ATP Rv1678 arabinogalactan: 6-O-cis-keto-mycolyl- - methoxy-mono-mycolate Probable 4-alpha- beta- Probable alpha- Cytochrome D-mannopyranosyl-1- Probable citrate Cytochrome SERYL-tRNA trehalose-cis- glucosidase: bglS glucosidase: aglA a C87-trans-keto- glucanotransferase: malQ (pro-3S)-lyase P450 51: cyp51 P450 51: methoxy-mycolate phosphoheptaprenol synthetase: salicyl-AMP mycolate-[pks13] maltose maltopentaose a non glucosylated D-glucopyranose maltopentaose (beta subunit): citE 14 cyp51 serS ligase: mbtA arabinogalactan:trehalose- mycolyltransferase: D-glucopyranose formate a Δ steroid trehalose-trans- 6-O-cis-keto-mycolyl-β- D-glucose acceptor 4,4-dimethyl- Rv0662c trans-methoxy- fbpB oxaloacetate acetate an L-seryl-sec (salicyl)adenylate methoxy-mono- D-mannopyranosyl-1- formate cholesta- Rv0943c mono-mycolate C87-trans- [tRNA ] mycolate:trehalose- phosphoheptaprenol:trehalose 8,14,24-trienol mycolyltransferase: fbpB keto-mycolate- trans-methoxy- arabinogalactan: [pks13-c-ppb] 6-phosphate mono-mycolate 6- trehalose-cis- mycolyltransferase: mycolyltransferase: lpqX methoxy-mycolate mycolyltransferase: arabinogalactan:trehalose- Rv3802c Tig maltotetraose D-glucopyranose a 1,3-β-D-glucan maltopentaose 1-oleoyl- C31- fbpB trans-methoxy- mycolyltransferase: obtusifoliol formate InfA 6-O-cis-keto-mycolyl- sn-glycerol phthiodiolone A mono-mycolate fbpA 6-O-trans-keto-mycolyl- trehalose 6-phosphate Probable 4-alpha- beta-1,3- Probable alpha- trehalose-cis-methoxy-mycolyltransferase: fbpA β Cytochrome monoacylglycerol Possible formate -D-mannopyranosyl- glucanase: Rv0315 glucosidase: aglA phthiodiolone glucanotransferase: malQ P450 51: cyp51 dehydrogenase mycolate:trehalose- 1-phosphoheptaprenol lipase: Rv0183 ketoreductase: trehalose-trans- arabinogalactan: Trehalose 6- H: fdhF cis-methoxy-mycolate maltose maltotriose D-glucopyranose a 1,3-β-D-glucan D-glucopyranose maltotetraose 4α-methyl-5α-ergosta- Rv2951c TcrA methoxy-mono- arabinogalactan:trehalose- oleate glycerol 6-mycolyltransferase: trehalose-cis- phosphate formate β Rv0879c trans-methoxy- 6-O-trans-keto-mycolyl- 8,14,24(28)-trien-3 -ol mycolate:trehalose- methoxy-mycolate phosphatase: A(H2) CO 2 fbpB β-D-mannopyranosyl-1- C31-phthiotriol trans-methoxy- mono-mycolate mycolyltransferase: otsB2 mono-mycolate 6- mycolyltransferase: fbpC fbpC phosphoheptaprenol:trehalose mycolyltransferase: trehalose-cis-methoxy- 6-phosphate [+ 2 isozymes] Rv0587 fbpA mycolate:trehalose- mycolyltransferase: lpqX trehalose-cis-keto- a maltodextrin D-glucopyranose a 1,4-α-D-glucan maltotriose a dipetide with an N- Rv3773c arabinogalactan-trans- cis-methoxy-mycolate maltoheptaose 2-oleoylglycerol cellulose trehalose-cis- arabinogalactan-cis- mono-mycolate terminal L-aspartate methoxy-mycolate 6-mycolyltransferase: 6-O-trans-keto-mycolyl- methoxy-di-mycolate methoxy-mycolate Probable 4-alpha- Probable alpha- Probable alpha- Probable alpha- fbpA trehalose 6-phosphate monoacylglycerol dipeptidase: Possible trehalose-trans- glucanotransferase: malQ glucosidase: aglA glucosidase: aglA glucosidase: aglA trehalose-cis- lipase: Rv0183 pepE cellulase: celA1 methoxy-mono- LprB keto-mono- maltose α mycolate:trehalose- Trehalose 6- a maltodextrin D-glucopyranose a 1,4- -D-glucan D-glucopyranose maltohexaose D-glucopyranose maltose glycerol a proteinogenic [+ 2 isozymes] trehalose-cis-methoxy- mycolate oleate asp Rv0479c trans-methoxy- phosphate amino acid mycolate:trehalose- transporter: a cellodextrin mono-mycolate 6- phosphatase: cis-methoxy-mycolate Rv1273c mycolyltransferase: otsB2 6-mycolyltransferase: fbpC fbpC Rv2354 [+ 2 isozymes] trehalose-cis-keto- mono-mycolate Rv0464c trehalose-trans- trehalose-trans- keto-mono-mycolate methoxy-di-mycolate trehalose-cis-keto- arabinogalactan:trehalose- trehalose- Rv1226c mycolate:trehalose- cis-keto-mycolate trans-keto- Rv2265 cis-keto-mycolate 6- mycolyltransferase: fbpB mono-mycolate mycolyltransferase: transporter: arabinogalactan:trehalose- fbpB Rv1273c cis-keto-mycolate a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acid ProX mycolyltransferase: fbpA Rv3506 cis-vaccenoyl-CoA cis-vaccenate trehalose-trans- trehalose-cis-keto- keto-mono-mycolate mycolate:trehalose- arabinogalactan:trehalose- cis-keto-mycolate 6- a 2,3,4-saturated fatty acyl CoA cis-keto-mycolate Rv0035 a 2,3,4-saturated fatty acid mycolyltransferase: mycolyltransferase: fbpC cis-vaccenoyl-CoA cis-vaccenate Rv1918c fbpA trehalose-trans-keto- arabinogalactan:trehalose- mycolate:trehalose- trans-keto-mycolate a 2,3,4-saturated fatty acyl CoA Rv3089 a 2,3,4-saturated fatty acid arabinogalactan- trans-keto-mycolate mycolyltransferase: fbpB cis-vaccenoyl-CoA cis-vaccenate trehalose-cis- cis-keto-mycolate 6-mycolyltransferase: arabinogalactan:trehalose- keto-mono- a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acid fbpB Rv0166 RpsF trans-keto-mycolate mycolate:trehalose- cis-vaccenoyl-CoA cis-vaccenate mycolyltransferase: fbpA cis-keto-mono- trehalose-trans-keto- mycolate 6- a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acid mycolate:trehalose- arabinogalactan:trehalose- mycolyltransferase: Rv1750c cis-vaccenoyl-CoA cis-vaccenate trans-keto-mycolate trans-keto-mycolate fbpC Rv1871c 6-mycolyltransferase: mycolyltransferase: fbpC fbpA

arabinogalactan- trehalose-cis-keto-di-mycolate trehalose-trans-keto- trans-keto-mycolate Rv0955 mycolate:trehalose- Rv3301c trans-keto-mycolate 6-mycolyltransferase: fbpC

Rv3269 Rv2426c trehalose-trans- keto-di-mycolate

Frr trehalose-cis-methoxy-mono-mycolate a lipopolysaccharide an O-antigen trehalose-trans-methoxy-mono-mycolate a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA a 2,3,4-saturated fatty acyl CoA trehalose-cis-keto-mono-mycolate cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA cis-vaccenoyl-CoA trehalose-trans-keto-mono-mycolate

predicted ABC predicted ABC transporter of transporter of Rv1769 SufR EphD Rv0037c Rv3727 Rv1551 Rv3040c Rv1964 GlnB Rv1290c Rv0228 Rv2807 Rv3197 Rv1757c Rv3256c Rv1085c Rv3304 Rv0453 Rv1967 Rv3481c MoeY Rv1744c FtsY Rv1861 Rv1924c Rv2360c Rv3860 Rv0281 FusA Rv1829 Rv1528c Rv0175 Rv3863 SigM Pra FbiC RpsI Rv2005c LprJ Rv2119 RpsE Rv1111c Rv0814c Rv1273c Rv1566c Rv2616 Rv2567 FtsZ Rv0986 Rv2772c RpsD Rv3395c Rv1487 Rv0332 DinG Rv3831 Rv0128 RuvA FbiB Rv3217c Rv1342c OppA Rv2329c Rv1892 Rv0008c Rv0696 Rv1370c Rv2434c Rv1261c Rv1937 Rv0024 FtsQ FadD32 Rv0270 Rv1549 Rv0119 Rv2590 Rv0099 Rv1206 Rv0551c Rv2505c Rv1427c Rv0852 Rv2187 Rv3513c Rv0214 Rv1550 Rv2120c Rv3208 Rv1738 RsmI Rv2459 Rv0987 Rv1706A Rv0256c Rv1333 an O-antigen/a an O-antigen/a lipopolysaccharide lipopolysaccharide

a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid a 2,3,4-saturated fatty acid trehalose-cis-methoxy-mono-mycolate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate cis-vaccenate trehalose-trans-methoxy-mono-mycolate trehalose-cis-keto-mono-mycolate a lipopolysaccharide an O-antigen trehalose-trans-keto-mono-mycolate Copyright 2019, SRI International. All Rights Reserved. This diagram was automatically generated by SRI International Pathway Tools version 23.5, authors S. Paley and P.D. Karp.