Testing Catalog
A COMPLETE GUIDE TO ZRT LABORATORY
www.zrtlab.com Table of Contents
About ZRT Laboratory...... 1
A Note from our Founder...... 2
The ZRT Difference ...... 3
Overview of Kits ...... 5
Multiple Testing Options – Your Choice...... 7
Our Comprehensive Range of Test Specialties ...... 11
Reproductive Hormone Testing...... 13
Hormone Metabolites ...... 18
Adrenal/Stress Testing ...... 19 The only way to know if hormones Thyroid Testing ...... 20 are in balance is to test them. Heavy Metals & Essential Elements Testing ...... 22 Neurotransmitter Testing ...... 24
Wellness Testing ...... 29
Methylation & Memory Testing ...... 30
Understanding ZRT’s Test Report ...... 31
Directory of Tests & CPT codes ...... 33
Billing Practices...... 35
Clinical Research & Study Testing...... 37
General Information ...... 40 A NOTE FROM OUR FOUNDER ABOUT ZRT LABORATORY A Note from our Founder
We are the science behind testing.
Hormones produced by endocrine glands (ovaries, testes, thyroid, pituitary, pancreas, etc.) are About ZRT Laboratory released into the bloodstream where they bind to carrier proteins and are slowly released into tissues throughout the body.
Various body fluids have been successfully used to monitor the levels of hormones which include blood from venipuncture (serum or plasma), capillary whole blood (blood spot), saliva, and urine. The only way to know if hormones Blood is traditionally collected by venipuncture and separated into serum or plasma. Capillary blood are in balance is to test them. can also be collected from the fingertip or heel (in infants) and drops deposited onto filter paper Est. 1998 - Portland, OR and dried, which is referred to as dried blood spot (DBS). Blood provides a convenient means to Therefore, it’s vital to partner with a lab that understands ZRT Laboratory is a CLIA-certified measure levels of steroid and peptide hormones; however, it measures total circulating hormone subtle differences between testing methods, and has both commercial and research laboratory including hormone bound to carrier proteins and requires a separate calculation to determine how the experience and technology to deliver the most accurate founded by breast cancer researcher much of the hormone is bioavailable to target cells. Also, diurnal patterns of hormone production results. David Zava, Ph.D. ZRT Laboratory has cannot be measured conveniently in blood. pioneered innovative testing methods With numerous peer-reviewed studies validating that hormone for hormones, neurotransmitters, Saliva is a convenient matrix for measuring steroid hormone levels because the sample collection test results support symptomatology, science now recognizes heavy metals and more, offering is simple and non-invasive (just spit into a tube) and the amount of steroid is representative of the that hormones are a fundamental part of treating the whole health care professionals convenient bioavailable fraction available to tissues – about 1-5% of the total circulating in blood. Because of body. Evidence shows that hormonal imbalances are the root testing options in different body the lower concentration it challenges methods of detection and requires 10- to 100-fold greater cause of many chronic health issues. fluids including saliva, dried blood sensitivity in detection methods. Saliva cannot be used to test peptide hormones. spot, dried urine, and serum. Since it With 20 years of experience and results from over 11 million began, ZRT has maintained a singular Urine is also a convenient method for measuring total hormone production; it contains a high tests, ZRT Laboratory is a recognized leader in innovative focus: providing comprehensive concentration of steroid metabolites and is simple to collect. Dried urine is even easier to collect at and meaningful hormone and wellness testing, being the first and meaningful test results that only 4 time points during the day and permits evaluation of diurnal patterns of hormone production. to commercialize many tests now considered mainstream. assist health care providers, and Disadvantages are that it only looks at metabolites scheduled for disposal by the body. It is not Health care providers in all 50 states and 96 countries, and their patients, in making informed possible to determine how much active hormone is present in circulation. Also, it must be processed research teams worldwide, use our tests, including the CDC, treatment decisions. by enzyme digestion and is time consuming. Topical hormones cannot be monitored in urine as the NIH and many renowned universities. they are mostly excreted in bile and very little is detected in urine.
ZRT has developed convenient, at-home collection methods for all these options – giving maximum DR. DAVID ZAVA flexibility and optimal results for health care providers. FOUNDER
Breast cancer researcher and biochemist David Zava, PhD founded ZRT in 1998. His desire to innovate the science of hormone testing provides the guiding force David Zava behind development of all ZRT’s technology.
1 2 THE ZRT DIFFERENCE THE ZRT DIFFERENCE
The ZRT Difference When choosing a laboratory, it’s crucial to partner with a group that has unmatched expertise and state-of-the-art technology to deliver the most accurate results and make it easy for you to get on board.
Advancing the Science of Testing Comprehensive Test Reports
✔ Ongoing clinical research, published in peer-reviewed journals ✔ Test results correlate hormone levels with reported symptoms and presented at scientific meetings, in collaboration with investigators and hormone supplementation. around the world including the CDC, NIH, the military and academic research centers. ✔ All reports are physician-reviewed with individualized comments, and include previous test results to compare current and past hormone levels to monitor patient progress. Accuracy ✔ Secure, online access to test reports. ✔ We ensure accurate test results for low-concentration hormones such as estradiol by using an extraction process for saliva testing. Provider Support & Education ✔ Precision and accuracy are maintained with rigorous proficiency testing both internally and externally. ✔ On-call clinical consultants available without appointment to consult with medical practitioners regarding hormone testing and bioidentical treatment approaches. Flexibility & Convenience ✔ Complimentary educational webinars for medical professionals presented by ✔ We offer all four test mediums (saliva, blood spot, dried urine, and serum) physician experts in the areas of physiology and endocrinology; complimentary and a varied menu of tests, allowing maximum flexibility and optimal patient education webinars. timing of sampling. ✔ Patient education brochures and point-of-sale displays. ✔ First-morning saliva sampling measures peak hormone levels and ensures correspondence with supplementation ranges that depend on time since ✔ Online access to resource materials, webinars, and reference documents. last hormone use. No need to collect four daily samples except when testing diurnal cortisol. ✔ Discounted yearly testing for provider employees.
✔ We determine reference ranges for individual patient ages, menstrual status, and hormone supplementation, so patients don’t need to stop taking hormones to use our testing.
✔ Turn-around time 3-5 business days.
3 4 OVERVIEW OF KITS | SPECIALTY KITS OVERVIEW OF KITS | STANDARD KITS Overview of Kits | Standard Kits Overview of Kits | Specialty Kits
SALIVA NEUROTRANSMITTERS HEAVY METALS & Female / Male Saliva Profile I: E2, Pg, T, DS, C Hormone Trio - Saliva: E2, Pg, T NeuroAdvanced Profile: ESSENTIAL ELEMENTS Female / Male Saliva Profile II: E2, Pg, T, DS, Cx2 Adrenal Stress: DS, Cx4 Dried Urine: GABA, Glu, Gly, DA, Iodine Panel Female / Male Saliva Profile III: E2, Pg, T, DS, Cx4 Diurnal Cortisol: Cx4 Epi, NE, HIST, 5-HT, PEA, DOPAC, I, Crtn HVA, 5-HIAA, NMN, VMA Trp, Kyn, LCMS Saliva Steroid Profile:E2, E3, E1, EE, PregS, 3-OHkyn, Tau, Gln, His, N-MeHist, Toxic & Essential Elements - Urine Pg, AlloP, 17OHPg, Adione, T, DHT, D, DS, 7keto, Tyra, KynAc, Xanth, Tyr & Crtn I, Br, Se, Li, As, Cd, Hg, Crtn 11DC, C, Cn, Ccn, Ald, Mel, ANZ, FIN, LTZ Toxic & Essential Elements - Blood URINE METABOLITES Zn, Cu, Mg, Se, Cd, Pb, Hg Adrenal Profile DRIED BLOOD SPOT Comprehensive Toxic & Essential Elements Estrogen Essential Profile Blood Spot: Zn, Cu, Mg, Se, Cd, Pb, Hg Female Blood Profile I: Vitamin D: 25-OH D2, 25-OH D3, total Estrogen Elite Profile Urine: I, Br, Se, Li, As, Cd, Hg, Crtn E2, Pg, T, SHBG, DS, C CardioMetabolic Profile: Basic Metabolites Profile Elite Thyroid Profile In, hsCRP, HbA1c, TG, CH, HDL, LDL, VLDL Female Blood Profile II: Advanced Metabolites Profile T4, Tgbn, TSH, fT3, fT4, TP0ab E2, Pg, T, SHBG, DS, C, TSH, fT3, fT4, TPOab Toxic & Essential Elements - Blood: Zn, Cu, Mg, Se, Cd, Pb, Hg Male Blood Profile I: SLEEP BALANCE Essential Thyroid Profile: E2, T, PSA, SHBG, DS, C Dried Urine: Melatonin WEIGHT MANAGEMENT TSH, fT3, fT4, TPOab (MT6s) x4,Free Cortisol x4, Male Blood Profile II: Saliva: E2, Pg, T, DS, Cx4 Elite Thyroid Profile: E2, T, PSA, SHBG, DS, C, TSH, fT3, fT4, TPOab Free Cortisone x4, Crtn Blood Spot: TSH, 25-OH D2, 25-OH D3, T4, Tgbn, TSH, fT3, fT4, TP0ab Hormone Trio - Blood: E2, Pg, T HbA1c, In
ADRENAL STRESS SALIVA + BLOOD Saliva: DS, Cx4 Comprehensive Female Profile I: Comprehensive Male Profile I: The Wellness Suite Saliva: E2, Pg, T, DS, Cx4 Saliva: E2, T, DS, Cx4 Blood Spot: TSH, fT3, fT4, TPOab Blood Spot: PSA, TSH, fT3, fT4, TPOab Comprehensive Female Profile II: Comprehensive Male Profile II: Saliva: Cx4 Saliva: Cx4 CORTISOL AWAKENING WELLNESS METRICS Blood Spot: E2, Pg, T, SHBG, DS, Blood Spot: E2, T, SHBG, PSA, DS, TSH, RESPONSE Saliva: E2, Pg, T, DS, Cx4 TSH, fT3, fT4, TPOab fT3, fT4, TPOab Saliva: DS, Cx6 Blood Spot: TSH, D2/D3, In, HbA1c
BLOOD + URINE Comprehensive Thyroid Profile: Comprehensive Toxic & Essential Elements Dried Urine: I, Se, Br, Li, As, Cd, Hg, Crtn Blood Spot: Zn, Cu, Mg, Se, Cd, Pb, Hg MENSTRUAL CYCLE FITNESS METRICS Blood Spot: T4, Tgbn, TSH, fT3, fT4, TPOab Urine: I, Br, Se, Li, As, Cd, Hg, Crtn MAPPING Blood Spot: E2, Pg, T, DS, C, SHBG, Dried Urine: E1G, PDG, LH, TSH, D2/D3, TG, CH, HDL, LDL, VLDL Crtn
BLOOD DRAW Female Serum Hormones Basic Profile: Methylation Profile: FERTILITY ELITE ATHLETE METRICS E2, Pg, T, SHBG, DS, C, TSH FER, FOL, HCY, B12 Saliva: Cx4 Saliva: E2, Pg, T, DS, Cx4 Female Serum Hormones Advanced Profile: Methylation & Memory Basic Profile: Blood Spot: E2, Pg, T, SHBG, Blood Spot: TSH, fT3, fT4, TPOab, D2/D3 E2, Pg, T, SHBG, DS, C, TSH, fT3, fT4, E2, Pg, T, TSH, FOL, HCY, B12, BDNF DS, TSH, fT3, fT4, TPOab, TPOab, FSH, LH, FER Methylation & Memory Advanced Profile: FSH, LH Male Serum Hormones Basic Profile: E2, Pg, T, SHBG, DS, C, TSH, fT3, fT4, E2, T, PSA, SHBG, DS, C, TSH TPOab, FER, FOL, B12, HCY, BDNF Male Serum Hormones Advanced Profile: About ZRT Laboratory Test Kits E2, T, PSA, SHBG, DS, C, TSH, fT3, fT4, TPOab, LH, PRL, FER Our all-inclusive test kits are simple and convenient for both patients and providers. All kits (except serum) are designed for private sample collection at home, at the optimal time. 5 6 TESTING OPTIONS 8
Endogenous sex hormone levels are identical in serum and blood spot. Endogenous sex hormone levels are therapy is used, blood spot has But when topical or vaginal hormone an advantage in that it reflects tissue uptake of the administered hormone. Saliva testing can be used to monitor all types of hormone supplementation the except troche/sublingual hormones because of direct contamination of sample with the administered hormone. Dried urine is generally not suitable for monitoring sex hormone replacement to because it does not reflect tissue uptake of topical steroids, is subject contamination with vaginally delivered hormones, and hormone metabolites interfere with testing levels of oral and pellet dosage forms. Measuring steroid hormone metabolites, e.g., for breast cancer risk Measuring steroid hormone metabolites, and iodine/selenium sufficiency Determining toxic element exposure for thyroid health at 4 time points for stress assessment Determining diurnal cortisol production production Assessing nocturnal and diurnal melatonin replacement therapy Monitoring topical or intravaginal hormone • • • DRIED URINE TESTING DRIED URINE Suitable for: • assessment • • • Not suitable for: • Media Following Sex Steroid Hormones in Different Test Testing Different Routes of Hormone Administration Testing for Steroid Hormone Levels Testing patients cope with hormone health care practitioners face the challenge of helping Today’s is optimal. imbalance. Accurate testing is the best way to make sure hormone dosing learn more, visit www.zrtlab.com/sample-types/hormone-testing-for-different-supplementation-types/ To
best
Toxic and nutritional elements requiring a whole blood sample Toxic of sample at home at a time convenient to the patient Self-collection and avoiding a trip to the phlebotomist Patients with dry mouth and/or children who may have difficulty collecting with dry mouth and/or children who may Patients Monitoring hormone replacement therapy (oral, sublingual, pellet) Assessing thyroid health, fertility parameters, and cardiometabolic risk Assessing interstitial tissue/capillary hormone levels reflecting topical or vaginal hormone supplementation Monitoring sublingual/troche hormone replacement Monitoring sublingual/troche hormone dry mouth, e.g., due to Sjogren’s Syndrome with Patients Assessing total circulating hormone levels (free plus protein-bound) Assessing “free” (unbound to carrier proteins) hormone levels Assessing “free” (unbound to carrier vaginally topically, orally, Monitoring hormone replacement given or via pellets e.g., determining diurnal a day, Collecting multiple samples during cortisol levels for adrenal stress assessment • • • saliva • • factors Dried Blood Spot better for: • • • TESTING BLOOD SPOT OR SERUM DRIED BLOOD Suitable for: • SALIVA TESTING SALIVA TESTING Suitable for: • • • Not suitable for: for your and your patient’s needs. Here is a guide to the merits patient’s needs. Here is for your and your option of each test medium. Multiple Testing Options Options Testing Multiple Choice – Your can choose the 4 different test media so you offers testing in ZRT
TESTING OPTIONS 7 TEST SPECIALTIES TEST SPECIALTIES Our Comprehensive Heavy Metals & Essential Elements Testing ������������������������������ Pages 22-24 Range of Test Specialties Exposure to dangerous heavy metals or insufficiency of nutritional elements affects health profoundly. Testing elements in the most appropriate sample type is important for proper assessment.
Iodine Panel in Dried Urine Reproductive Hormone Testing ���������������������������������������������� Pages 11-18 Toxic & Essential Elements – Urine Toxic & Essential Elements – Blood Keeping hormones in balance means testing to ensure levels are within physiological, age- Comprehensive Toxic & Essential Elements Profile appropriate ranges. Our range of testing options covers your assessment needs for menopause, andropause, menstrual health, fertility, and breast cancer risk.
Female/Male Saliva Profiles I, II & III Neurotransmitter Testing ����������������������������������������������������� Pages 25-27 Female Blood Profiles I & II Testing neurotransmitters can help pinpoint imbalances leading to many mood disorders. Male Blood Profiles I & II Choose our NeuroAdvanced profile alone or add on any of the available options – sex Hormone Trio – Saliva hormones, diurnal cortisol, elements, or melatonin – to get a more complete picture, giving Hormone Trio – Blood Spot practitioners a diagnostic edge to help identify treatment options. Comprehensive Female Profiles I & II Comprehensive Male Profiles I & II NeuroAdvanced Profile Female Serum Hormones – Basic & Advanced Profiles Male Serum Hormones – Basic & Advanced Profiles Fertility Profile Wellness Testing ��������������������������������������������������������������� Pages 28-29 Menstrual Cycle Mapping Optimal wellness means getting to grips with modifiable lifestyle factors that can have a big LCMS Saliva Steroid Profile impact on health. Whether assessing vitamin D deficiency, risk factors for cardiovascular Urine Metabolites disease and diabetes, barriers to healthy sleep, or hormone imbalances hindering your path to fitness, our profiles offer multiple testing options.
Adrenal/Stress Testing �������������������������������������������������������� Page 19 Weight Management Profile Sleep Balance Profile Assessment of diurnal cortisol levels is key to detecting adrenal dysfunction that leads to many CardioMetabolic Profile stress-related health problems. Wellness Metrics Profile Diurnal Cortisol Profile Fitness Metrics Profile Adrenal Stress Profile Elite Athlete Metrics Profile Cortisol Awakening Response Profile
Methylation & Memory Testing ���������������������������������������������� Pages 30-31 Thyroid Testing ����������������������������������������������������������������� Page 20-21 Nutritional factors involved in methylation pathways are vital to the health of the Proper thyroid function is essential to maintaining the body’s metabolic activity and regulating cardiovascular and nervous systems and to safe steroid hormone metabolism. Our profiles energy. Our profiles identify overt and subclinical thyroid disease and monitor thyroid replacement. assess these factors as well as multiple hormones and BDNF. If these are not at optimal Get a more complete picture with profiles that combine thyroid tests with our other hormone testing levels, risks for cardiovascular disease and dementia can increase. or with heavy metals and essential elements tests that affect thyroid health. Methylation Profile Essential & Elite Thyroid Profiles Methylation & Memory – Basic & Advanced Profiles Comprehensive Thyroid Profile Comprehensive Female Profiles I & II Comprehensive Male Profiles I & II 9 10 TEST SPECIALTIES | SEX HORMONE PROFILES TEST SPECIALTIES | SEX HORMONE PROFILES Hormone Trio - Saliva Consider for Women: Female / Male Saliva Profiles I, II & III Consider for Women: Baseline levels before hormone replacement Baseline levels before hormone replacement Combines three of our most popular saliva hormone therapy, amenorrhea, PMS, DUB (dysfunctional Three convenient saliva profiles are offered to assesssex therapy, amenorrhea, PMS, dysfunctional uterine tests at a lower price than individual tests. uterine bleeding), estrogen dominance symptoms, and adrenal hormone levels. These profiles test waking bleeding (DUB), estrogen dominance symptoms, hypogonadism, sexual dysfunction, osteoporosis, levels of estradiol, progesterone, testosterone, DHEA-S, hypogonadism, sexual dysfunction, osteoporosis, ✔ Hormone Trio includes: E2, Pg, T fibrocystic breast disease, PCOS screening, and cortisol, while Profile II includes a bed-time cortisol fibrocystic breast disease, infertility screening, anovulation, menopausal symptoms. Ideal for test and Profile III a full diurnal cortisol profile at four time polycystic ovarian syndrome (PCOS) screening, monitoring HRT dosing. points during the day (morning, noon, evening, night). anovulation, menopausal symptoms, screening for adrenal fatigue. Ideal for monitoring HRT dosing. Consider for Men: ✔ Saliva Profile I includes: E2, Pg, T, DS, C Monitor for estrogen dominance, hypogonadism, ✔ Saliva Profile II includes: E2, Pg, T, DS, Cx2 Consider for Men: andropause, fatigue, low libido, erectile dysfunction, ✔ Saliva Profile III includes: E2, Pg, T, DS, Cx4 Monitor for estrogen dominance, hypogonadism, osteoporosis screening. andropause, fatigue, low libido, erectile dysfunction, infertility, osteoporosis screening, and adrenal dysfunction.
Hormone Trio - Blood Spot Consider for Women: Baseline levels before hormone replacement Female Blood Profile I tests the primary female sex Female Blood Profiles I & II Combines three of our most popular hormone tests therapy, amenorrhea, PMS, DUB (dysfunctional hormones and their major binding globulin, and at a lower price than individual tests. uterine bleeding), estrogen dominance symptoms, Two dried blood spot profiles are offered for women: screens for adrenal health through morning cortisol. Profile I tests sex and adrenal hormone levels in blood, hypogonadism, sexual dysfunction, osteoporosis, ✔ Hormone Trio includes: E2, Pg, T as an alternative to Saliva Profile I for those women who Consider for assessment of total baseline levels fibrocystic breast disease, PCOS screening, have difficulty producing enough saliva for testing, or who before hormone replacement therapy, adrenal anovulation, menopausal symptoms. Ideal for are using sublingual hormones that might interfere with fatigue, amenorrhea, anovulation, DUB (dysfunctional monitoring HRT dosing. uterine bleeding), estrogen dominance symptoms, the saliva test. SHBG is included in the profile so that free Consider for Men: fibrocystic breast disease, hypogonadism, infertility (unbound) testosterone can be calculated, since most Monitor for estrogen dominance, hypogonadism, screening, menopausal symptoms, osteoporosis, of the testosterone circulating in the blood is bound to andropause, fatigue, low libido, erectile PCOS screening, PMS, sexual dysfunction. SHBG. Profile II includes the same tests as Profile I with dysfunction (ED), osteoporosis screening. the addition of the Essential Thyroid Profile tests. Female Blood Profile II is a more comprehensive ✔ Female Blood Spot Profile I includes: assessment of hormonal and thyroid imbalances. E2, total; Pg, total; T, total; SHBG; DS; C The Female Serum Profile includes the same tests. ✔ Female Blood Spot Profile II adds: Comprehensive Female Profile I combines ZRT’s TSH, fT3, fT4, TPOab Comprehensive Female Profiles popular Salivary Hormone Profile III with our ✔ Female Serum Profile includes: These profiles include both saliva and dried blood spot Essential Thyroid Profile tests in dried blood spot. E2, Pg, T, SHBG, DS, C,TSH, fT3, fT4, TPOab tests, and provide a broad assessment of possible hormonal imbalances because they assess sex, Comprehensive Female Profile II tests only the adrenal, and thyroid hormone levels. These three diurnal cortisol in saliva, while the sex and thyroid hormone systems work in harmony, and an imbalance hormones are all tested in dried blood spot. in one system affects the balance of the others as well. Allows physicians to assess baseline levels before Male Blood Profile I tests the primary male sex Male Blood Profiles I & II Comprehensive testing allows the health care provider hormone replacement therapy; ideal for monitoring hormones and their major binding globulin, and to determine appropriate treatment to restore balance HRT dosing. Full assessment of thyroid health, Two dried blood spot profiles are offered for men: screens for adrenal health through morning cortisol. and achieve overall wellness. including screening for hypo or hyperthyroidism, Profile I tests sex and adrenal hormone levels in blood, Consider for monitoring for estrogen dominance, determining Free T4 levels as well as Free T3 and includes a PSA test to help assess prostate health. hypogonadism, andropause, fatigue, low ✔ Comprehensive Female Profile I includes: levels, testing for autoimmune thyroid disease, and Profile II includes the same tests as Profile I with the libido, erectile dysfunction (ED), infertility, Saliva: E2, Pg, T, DS, Cx4 monitoring thyroid replacement dosage. addition of the Essential Thyroid Profile tests. osteoporosis screening, adrenal dysfunction. Blood Spot: TSH, fT3, fT4, TPOab Consider for: ✔ Comprehensive Female Profile II includes: ✔ Male Blood Spot Profile I includes: Amenorrhea, PMS, DUB (dysfunctional uterine Male Blood Profile II is a more comprehensive Saliva: Cx4 E2, total; T, total; PSA; SHBG; DS; C bleeding), estrogen dominance symptoms, assessment of hormonal and thyroid imbalances. Blood Spot: E2, total; Pg; T, total; SHBG; hypogonadism, sexual dysfunction, osteoporosis, ✔ Male Blood Spot Profile II adds: The Male Serum Profile includes the same tests. DS; TSH; fT3; fT4; TPOab fibrocystic breast disease, infertility screening, TSH, fT3, fT4, TPOab Don’t need PSA? Select one of the female PCOS screening, anovulation, menopausal ✔ Male Serum Profile includes: profiles instead. symptoms, screening for adrenal dysfunction, E2, T, PSA, SHBG, DS, C, TSH, fT3, fT4, TPOab and thyroid dysfunction. 11 12 TEST SPECIALTIES | SEX HORMONE PROFILES TEST SPECIALTIES | SEX HORMONE PROFILES Comprehensive Male Profiles Comprehensive Male Profile I combines a male version Male Serum Hormones Consider for: of ZRT’s popular Salivary Hormone Profile III with our Fatigue, sleep disturbance, These profiles include both saliva and dried blood spot Essential Thyroid Profile in dried blood spot. For men, – Basic & Advanced Profiles decreased cognition, depression, low tests, and provide a broad assessment of possible PSA is included instead of the less relevant (for men) libido, erectile dysfunction, infertility, hormonal imbalances because they assess sex, adrenal, salivary progesterone. Serum testing of sex hormones can be used to determine loss of bone & muscle mass, weight and thyroid hormone levels. These three hormone systems circulating endogenous hormone levels in men who are gain, adrenal and thyroid dysfunction. work in harmony, and an imbalance in one system affects Comprehensive Male Profile II tests only the diurnal not using topical hormone supplementation (see our dried the balance of the others as well. Comprehensive testing cortisol in saliva, while the sex and thyroid hormones blood spot or saliva testing options for men using hormone allows the health care provider to determine appropriate are all tested in dried blood spot. Allows physicians therapy). Basic profiles are a good start for testing proper treatment to restore balance and achieve overall wellness. to monitor for estrogen dominance, hypogonadism, balance of sex hormones, adrenal hormones, and TSH. andropause; full assessment of thyroid health, including The advanced profile provides a broader overview of the ✔ Comprehensive Male Profile I includes: screening for hypo or hyperthyroidism, determining health and balance of sex and thyroid hormones, and Saliva: E2, T, DS, Cx4 Free T4 levels as well as Free T3 levels, testing for include LH which, if low, can indicate excessive testosterone Blood Spot: PSA, TSH, fT3, fT4, TPOab autoimmune thyroid disease, and monitoring thyroid supplementation. Iron status, important for thyroid health, is replacement dosages. assessed with ferritin measurement. PSA and prolactin are ✔ Comprehensive Male Profile II includes: included as a prescreen for testosterone therapy to exclude Saliva: Cx4 Consider for: prostate issues and pituitary prolactinoma. Blood Spot: E2, total; T, total; SHBG; DS; PSA; TSH; fT3; fT4; Fatigue, sleep disturbance, decreased cognition, TPOab depression, low libido, erectile dysfunction (ED), ✔ Male Serum Hormones Basic Profile includes: infertility, loss of bone and muscle mass, weight E2, T, PSA, SHBG, DS, C, TSH gain, adrenal and thyroid dysfunction. ✔ Male Serum Hormones Advanced Profile includes: E2, T, PSA, SHBG, DS, C, TSH, fT3, fT4, TPOab, LH, PRL, FER Don’t need PSA? Select one of the female profiles instead.
Fertility Profile Fertility Profile meets the requirement for initial screening for fertility assessment The profile provides a thorough evaluation that can by reproductive endocrinologists. identify many problems related to hormone imbalances Assessment of ovarian reserve as well as Female Serum Hormones Consider for: that are associated with infertility. Dried blood spot screening for multiple common reasons samples are collected on days 3 and 21 of the menstrual – Basic & Advanced Profiles Amenorrhea, PMS, dysfunctional uterine bleeding, for infertility including: anovulation, PCOS, estrogen dominance symptoms, hypogonadism, cycle, and saliva samples are collected only on day hypothyroidism, premature ovarian failure 21. LH and FSH are tested on day 3, while on day 21 Serum testing of sex hormones can be used to determine sexual dysfunction, osteoporosis, fibrocystic or ovarian insufficiency. estradiol, progesterone, testosterone, DHEA-S, SHBG, circulating endogenous hormone levels in women who breast disease, infertility screening, PCOS and the thyroid hormones are tested in dried blood spot are not using topical or vaginal hormone supplementation screening, anovulation, menopausal symptoms, Consider for: adrenal and thyroid dysfunction. and diurnal cortisol is tested in saliva. (see our dried blood spot or saliva testing options for Women who have been trying to get women using hormone therapy). Basic profiles are a ✔ Fertility Profile includes: pregnant without success, or who would good start for testing proper balance of sex hormones, Saliva: Cx4 like to be proactive in their preconception adrenal hormones, and TSH. Advanced profiles provide Blood Spot: E2, total; Pg; T, total; SHBG; DS; TSH; fT3; fT4; planning by getting a baseline screening. a broader overview of the health and balance of sex and TPOab; FSH; LH thyroid hormones, and they include pituitary hormones that control ovarian production of the sex hormones and help define menopausal status. Iron status, important for thyroid health, is assessed with ferritin measurement. Consider for: ✔ Female Serum Hormones Basic Profile includes: Menstrual Cycle Mapping Consider for women with irregular cycles, E2, Pg, T, SHBG, DS, C, TSH This profile offers an assessment of sex hormone cyclic hormone-related symptoms such and LH patterns throughout a menstrual cycle to help ✔ Female Serum Hormones Advanced Profile includes: as pre-menstrual syndrome (PMS) or health care practitioners get to the root of hormone- headaches, infertility, or luteal phase defects E2, Pg, T, SHBG, DS, C, TSH, fT3, fT4, TPOab, FSH, LH, FER related menstrual symptoms, irregular cycles, to determine the source of their problems. amenorrhea, or infertility. Dried urine testing provides a simple and convenient way to assess fluctuations in daily hormone levels over an entire month, known as menstrual cycle mapping.
✔ Menstrual Cycle Mapping includes: Dried Urine: E1G, PDG, LH 13 14 TEST SPECIALTIES | HORMONE METABOLITES TEST SPECIALTIES | SEX HORMONE PROFILES LCMS Saliva Steroid Profile Consider for Women: Urine Hormone Metabolites Profiles Hair loss, acne, PCOS, topical DHEA or 7-keto The profile includes 23 tests all reported together DHEA supplementation, hormonal birth control from one convenient morning saliva collection. Tests users, adrenal dysfunction, or those treated with Five profiles give a broad range of choices for an assessment of how patients are metabolizing a variety include a broad range of bioavailable estrogens, hormone blockers for breast cancer. of hormones. androgens, progestogens and corticosteroids and ourtesy of They include: their metabolites; plus melatonin, ethinyl estradiol and Consider for Men: theSaliva hormone Steroid blockers anastrozole, Cascade finasteride and Hypogonadism, andropause, BPH, A wide array of estrogen, progesterone, and androgen metabolites useful for assessment of breast cancer risk letrozole. This provides a comprehensive picture of adrenal dysfunction, monitoring hormone Glucocorticoid metabolites, diurnal free cortisol, and diurnal free cortisone for adrenal assessment hormonal status and how hormonal birth control and supplementation. Diurnal 6-sulfatoxymelatonin (MT6s) to assess sleep / wake cycle dysfunction hormone blockers are affecting endogenous hormone availability. regnenolone ulfate A- - eto A The xenoestrogen Bisphenol A (BPA)
Sex steroid hormone metabolites results are useful for monitoring hormone therapy patients using patches, pellets ✔ LCMS Saliva Steroid Profile Includes: U U β or injectables. E2, E3, E1, EE, PregS, Pg, AlloP, 17OHPg, Adione, T, DHT, yase D, olesterolDS, 7keto, 11DC, C, Cn, re nenolone Ccn, Ald, Mel, ANZ, FIN, LTZ re nenolone A An rostene iol