PSYCHOACTIVE SUBSTANCES a Guide to Ethnobotanical Plants and Herbs, Synthetic Chemicals, Compounds and Products
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Hallucinogens - LSD, Peyote, Psilocybin, and PCP
Hallucinogens - LSD, Peyote, Psilocybin, and PCP Hallucinogenic compounds found in some • Psilocybin (4-phosphoryloxy-N,N- plants and mushrooms (or their extracts) dimethyltryptamine) is obtained from have been used—mostly during religious certain types of mushrooms that are rituals—for centuries. Almost all indigenous to tropical and subtropical hallucinogens contain nitrogen and are regions of South America, Mexico, and classified as alkaloids. Many hallucinogens the United States. These mushrooms have chemical structures similar to those of typically contain less than 0.5 percent natural neurotransmitters (e.g., psilocybin plus trace amounts of acetylcholine-, serotonin-, or catecholamine- psilocin, another hallucinogenic like). While the exact mechanisms by which substance. hallucinogens exert their effects remain • PCP (phencyclidine) was developed in unclear, research suggests that these drugs the 1950s as an intravenous anesthetic. work, at least partially, by temporarily Its use has since been discontinued due interfering with neurotransmitter action or to serious adverse effects. by binding to their receptor sites. This DrugFacts will discuss four common types of How Are Hallucinogens Abused? hallucinogens: The very same characteristics that led to • LSD (d-lysergic acid diethylamide) is the incorporation of hallucinogens into one of the most potent mood-changing ritualistic or spiritual traditions have also chemicals. It was discovered in 1938 led to their propagation as drugs of abuse. and is manufactured from lysergic acid, Importantly, and unlike most other drugs, which is found in ergot, a fungus that the effects of hallucinogens are highly grows on rye and other grains. variable and unreliable, producing different • Peyote is a small, spineless cactus in effects in different people at different times. -
Integrating Complementary Medicine Into Cardiovascular Medicine
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Journal of the American College of Cardiology Vol. 46, No. 1, 2005 © 2005 by the American College of Cardiology Foundation ISSN 0735-1097/05/$30.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2005.05.031 ACCF COMPLEMENTARY MEDICINE EXPERT CONSENSUS DOCUMENT Integrating Complementary Medicine Into Cardiovascular Medicine A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine) WRITING COMMITTEE MEMBERS JOHN H. K. VOGEL, MD, MACC, Chair STEVEN F. BOLLING, MD, FACC BRIAN OLSHANSKY, MD, FACC REBECCA B. COSTELLO, PHD KENNETH R. PELLETIER, MD(HC), PHD ERMINIA M. GUARNERI, MD, FACC CYNTHIA M. TRACY, MD, FACC MITCHELL W. KRUCOFF, MD, FACC, FCCP ROBERT A. VOGEL, MD, FACC JOHN C. LONGHURST, MD, PHD, FACC TASK FORCE MEMBERS ROBERT A. VOGEL, MD, FACC, Chair JONATHAN ABRAMS, MD, FACC SANJIV KAUL, MBBS, FACC JEFFREY L. ANDERSON, MD, FACC ROBERT C. LICHTENBERG, MD, FACC ERIC R. BATES, MD, FACC JONATHAN R. LINDNER, MD, FACC BRUCE R. BRODIE, MD, FACC* ROBERT A. O’ROURKE, MD, FACC† CINDY L. GRINES, MD, FACC GERALD M. POHOST, MD, FACC PETER G. DANIAS, MD, PHD, FACC* RICHARD S. SCHOFIELD, MD, FACC GABRIEL GREGORATOS, MD, FACC* SAMUEL J. SHUBROOKS, MD, FACC MARK A. HLATKY, MD, FACC CYNTHIA M. TRACY, MD, FACC* JUDITH S. HOCHMAN, MD, FACC* WILLIAM L. WINTERS, JR, MD, MACC* *Former members of Task Force; †Former chair of Task Force The recommendations set forth in this report are those of the Writing Committee and do not necessarily reflect the official position of the American College of Cardiology Foundation. -
Pharmacognostical Identification of Alchemilla Japonica Nakai Et Hara
© 2015 Journal of Pharmacy & Pharmacognosy Research, 3 (3), 59-68 ISSN 0719-4250 http://jppres.com/jppres Original Article | Artículo Original Pharmacognostical identification of Alchemilla japonica Nakai et Hara [Identificación farmacognóstica de Alchemilla japonica Nakai et Hara] Yun Zhu, Ningjing Zhang, Peng Li* School of Pharmacy, Shihezi University/Key Laboratory of Phytomedicine Resources & Modernization of TCM, Shihezi Xinjiang 832002, PR China. * E-mail: [email protected] Abstract Resumen Context: Alchemilla japonica is a therapeutically important medicinal Contexto: Alchemilla japonica es una planta medicinal, terapéutica- plant, which is widely used in traditional medicine external application mente importante, que se utiliza ampliamente en la medicina tradicional for injuries as well as orally for acute diarrhea, dysmenorrhea, and por aplicación externa en lesiones, así como por vía oral para la diarrea menorrhagia, among others. However, there is not a correct identification aguda, dismenorrea y menorragia, entre otras. Sin embargo, no hay una of this species and is of prime importance differentiate it from commonly correcta identificación de la especie y es de primordial importancia available adulterants or substitutes, in fresh, dried or powdered state. diferenciar esta de adulterantes comúnmente disponibles o sustitutos, en There is only a small number of data of pharmacological standards for estado fresco, seco o en polvo. Sólo hay un pequeño número de datos de identification and authentication of A. japonica. patrones farmacológicos para la identificación y autenticación de A. Aims: To characterize morpho-anatomically the roots, leaves and stems japonica. of Alchemilla japonica Nakai et Hara (Rosaceae), explore and establish the Objetivos: Caracterizar desde el punto de vista morfo-anatómico las micromorphology and quality control method for this plant. -
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Iranian Journal of Pharmaceutical Research (2014),13 (supplement): 195-198 Copyright © 2014 by School of Pharmacy Received: December 2013 Shaheed Beheshti University of Medical Sciences and Health Services Accepted: December 2013 Original Article Screening of 20 Commonly Used Iranian Traditional Medicinal Plants Against Urease Mahmood Biglara, Hessameddin Sufia, Kowsar Bagherzadeha, Massoud Amanloua and Faraz Mojabb* aDepartment of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Science Research Center, Tehran University of Medical Sciences, Tehran, Iran. bDepartment of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Abstract Infection with Helicobacter pyloriis the most common cause of stomach and duodenal ulcers. About more than 80 % of people are infected with H. pylori in developing countries. H. pylori uses urease enzyme product “ammonia” in order to neutralize and protect itself from the stomach acidic condition and urease enzyme activity has been shown to be essential to the colonization of H. pylori. Inhibitory activity of 20 traditional medicinal plants were examined and evaluated against Jack bean urease activity by Berthelot reaction to obtains natural sources of urease inhibitors. Each herb was extracted using 80% aqueous methanol, then tested its IC50 value was determined. Eight of the whole 20 studied plants crude extracts were found the most effective with IC50 values of less than 100 µg/mL including Laurus nobilis, Zingiber officinale, Nigella sativa, Angelica archangelica, Acorus calamus, Allium sativum,Curcuma longa, and Citrus aurantium extracts, from which most potent urease inhibitory was observed for Zingiber officinale, Laurus nobilis, and Nigella sativa with IC50 values of 48.54, 48.69 and 59.10 µg/mL, respectively. -
(12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao Et Al
USOO9498481 B2 (12) United States Patent (10) Patent No.: US 9,498,481 B2 Rao et al. (45) Date of Patent: *Nov. 22, 2016 (54) CYCLOPROPYL MODULATORS OF P2Y12 WO WO95/26325 10, 1995 RECEPTOR WO WO99/O5142 2, 1999 WO WOOO/34283 6, 2000 WO WO O1/92262 12/2001 (71) Applicant: Apharaceuticals. Inc., La WO WO O1/922.63 12/2001 olla, CA (US) WO WO 2011/O17108 2, 2011 (72) Inventors: Tadimeti Rao, San Diego, CA (US); Chengzhi Zhang, San Diego, CA (US) OTHER PUBLICATIONS Drugs of the Future 32(10), 845-853 (2007).* (73) Assignee: Auspex Pharmaceuticals, Inc., LaJolla, Tantry et al. in Expert Opin. Invest. Drugs (2007) 16(2):225-229.* CA (US) Wallentin et al. in the New England Journal of Medicine, 361 (11), 1045-1057 (2009).* (*) Notice: Subject to any disclaimer, the term of this Husted et al. in The European Heart Journal 27, 1038-1047 (2006).* patent is extended or adjusted under 35 Auspex in www.businesswire.com/news/home/20081023005201/ U.S.C. 154(b) by Od en/Auspex-Pharmaceuticals-Announces-Positive-Results-Clinical M YW- (b) by ayS. Study (published: Oct. 23, 2008).* This patent is Subject to a terminal dis- Concert In www.concertpharma. com/news/ claimer ConcertPresentsPreclinicalResultsNAMS.htm (published: Sep. 25. 2008).* Concert2 in Expert Rev. Anti Infect. Ther. 6(6), 782 (2008).* (21) Appl. No.: 14/977,056 Springthorpe et al. in Bioorganic & Medicinal Chemistry Letters 17. 6013-6018 (2007).* (22) Filed: Dec. 21, 2015 Leis et al. in Current Organic Chemistry 2, 131-144 (1998).* Angiolillo et al., Pharmacology of emerging novel platelet inhibi (65) Prior Publication Data tors, American Heart Journal, 2008, 156(2) Supp. -
Erowid Extracts — Number 13 / November 2007 Erowid Extracts Table of Contents Number 13, November 2007
Erowid® Extracts D OCUMENTING THE C OMPLEX R ELATIONSHIP B ETWEEN H UMANS AN D P SYCHOACTIVES November 2007 Number 13 “The problem to be faced is: how to combine loyalty to one’s own tradition with reverence for different traditions.” — Abraham J. Heschel The Absinthe Enigma • Wormwood and Thujone • P. viridis vs. M. tenuiflora Varieties of Nicotine Experience • Khat Legal Challenges LETTERS & FEEDBACK Hi there Erowid staff, First of all, thank you for such Awesome website! A more thoughtfully a wonderful site. I’m not a serious compiled compendium of information I’m just writing to say how much I recreational user, but having some on the topic of psychoactives does appreciate your website. My father chronic pain issues, I tend to experiment not exist—at least not for the public showed it to me several years ago a little to find ways to alleviate the at large. Bravo. and it’s been fun to watch it grow pain (aside from standard Rx’s from in quality and content over the — ANOnymOus doctors). […] years. My dad adjunctly teaches a Letter to Erowid psychopharmacology class in town and Keep up the good work. Although always lists Erowid on his syllabus of some might look at Erowid negatively, recommended readings. I’m a college I look at it positively, in the sense that After looking up information on the student and am surprised, once I I’m smart enough to research things antitussive properties of DXM, how start talking to other kids, how many before I try them, and hopefully keep shocked I was to find your website, of them know about the information myself from an early demise. -
Analysis of Paralogs in Target Enrichment Data Pinpoints Multiple Ancient Polyploidy Events
bioRxiv preprint doi: https://doi.org/10.1101/2020.08.21.261925; this version posted August 23, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 1 Analysis of paralogs in target enrichment data pinpoints multiple ancient polyploidy events 2 in Alchemilla s.l. (Rosaceae). 3 4 Diego F. Morales-Briones1.2,*, Berit Gehrke3, Chien-Hsun Huang4, Aaron Liston5, Hong Ma6, 5 Hannah E. Marx7, David C. Tank2, Ya Yang1 6 7 1Department of Plant and Microbial Biology, University of Minnesota-Twin Cities, 1445 Gortner 8 Avenue, St. Paul, MN 55108, USA 9 2Department of Biological Sciences and Institute for Bioinformatics and Evolutionary Studies, 10 University of Idaho, 875 Perimeter Drive MS 3051, Moscow, ID 83844, USA 11 3University Gardens, University Museum, University of Bergen, Mildeveien 240, 5259 12 Hjellestad, Norway 13 4State Key Laboratory of Genetic Engineering and Collaborative Innovation Center of Genetics 14 and Development, Ministry of Education Key Laboratory of Biodiversity and Ecological 15 Engineering, Institute of Plant Biology, Center of Evolutionary Biology, School of Life Sciences, 16 Fudan University, Shanghai 200433, China 17 5Department of Botany and Plant Pathology, Oregon State University, 2082 Cordley Hall, 18 Corvallis, OR 97331, USA 19 6Department of Biology, the Huck Institute of the Life Sciences, the Pennsylvania State 20 University, 510D Mueller Laboratory, University Park, PA 16802 USA 21 7Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 22 48109-1048, USA 23 bioRxiv preprint doi: https://doi.org/10.1101/2020.08.21.261925; this version posted August 23, 2020. -
Molecular Modeling of Major Tobacco Alkaloids in Mainstream Cigarette Smoke Caren Kurgat, Joshua Kibet* and Peter Cheplogoi
Kurgat et al. Chemistry Central Journal (2016) 10:43 DOI 10.1186/s13065-016-0189-5 RESEARCH ARTICLE Open Access Molecular modeling of major tobacco alkaloids in mainstream cigarette smoke Caren Kurgat, Joshua Kibet* and Peter Cheplogoi Abstract Background: Consensus of opinion in literature regarding tobacco research has shown that cigarette smoke can cause irreparable damage to the genetic material, cell injury, and general respiratory landscape. The alkaloid family of tobacco has been implicated is a series of ailments including addiction, mental illnesses, psychological disorders, and cancer. Accordingly, this contribution describes the mechanistic degradation of major tobacco alkaloids including the widely studied nicotine and two other alkaloids which have received little attention in literature. The principal focus is to understand their energetics, their environmental fate, and the formation of intermediates considered harmful to tobacco consumers. Method: The intermediate components believed to originate from tobacco alkaloids in mainstream cigarette smoke were determined using as gas-chromatography hyphenated to a mass spectrometer fitted with a mass selective detector (MSD) while the energetics of intermediates were conducted using the density functional theory framework (DFT/B3LYP) using the 6-31G basis set. Results: The density functional theory calculations conducted using B3LYP correlation function established that the scission of the phenyl C–C bond in nicotine and β-nicotyrine, and C–N phenyl bond in 3,5-dimethyl-1-phenylpyrazole were respectively 87.40, 118.24 and 121.38 kcal/mol. The major by-products from the thermal degradation of nicotine, β-nicotyrine and 3,5-dimethyl-1-phenylpyrazole during cigarette smoking are predicted theoretically to be pyridine, 3-methylpyridine, toluene, and benzene. -
Anticancer Effects of NSC‑631570 (Ukrain) in Head and Neck Cancer Cells: in Vitro Analysis of Growth, Invasion, Angiogenesis and Gene Expression
282 ONCOLOGY REPORTS 43: 282-295, 2020 Anticancer effects of NSC‑631570 (Ukrain) in head and neck cancer cells: In vitro analysis of growth, invasion, angiogenesis and gene expression RUTH HERRMANN1, JOSEPH SKAF2, JEANETTE ROLLER1, CHRISTINE POLEDNIK1, ULRIKE HOLZGRABE2 and MARIANNE SCHMIDT1 1Department of Otorhinolaryngology, University of Würzburg, D-97080 Würzburg; 2Institute of Pharmacy and Food Chemistry, University of Würzburg, D-97074 Würzburg, Germany Received September 17, 2018; Accepted September 30, 2019 DOI: 10.3892/or.2019.7416 Abstract. NSC-631570 (Ukrain) is an aqueous extract of laminin). Microarray analysis revealed the downregulation of Chelidonium majus, a herbaceous perennial plant, one of two genes encoding key regulators, including EGFR, AKT2, JAK1, species in the genus Chelidonium, which has been demonstrated STAT3 and ß-catenin (CTNNB1), all of which are involved in to selectively kill tumor cells without affecting non-malignant cell proliferation, migration, angiogenesis, apoptosis as well as cells. In the present study, the components of NSC-631570 the radiation- and chemo-resistance of HNSCC. The strongest were examined by combined liquid chromatography/mass upregulation occurred for cytochrome P450 1A1 (CYP1A1) spectroscopy (LC-MS) and the effects of NSC-631570 on and 1B1 (CYP1B1), involved in the metabolism of xenobiotics. HNSCC cell lines, as well as primary cells, were analyzed Upregulation of CYP1A1 was at least partially caused by chel- with respect to growth, apoptosis, invasion, angiogenesis erythrine and allocryptopine, as shown by RT-qPCR in two and gene expression. LC-MS identified chelerythrine and HNSCC cell lines. In addition, NSC-631570 showed a high allocryptopine as the major alkaloids of the extract. -
Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
www.sciencemag.org/cgi/content/full/327/5963/348/DC1 Supporting Online Material for Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation Jason Rihel,* David A. Prober, Anthony Arvanites, Kelvin Lam, Steven Zimmerman, Sumin Jang, Stephen J. Haggarty, David Kokel, Lee L. Rubin, Randall T. Peterson, Alexander F. Schier* *To whom correspondence should be addressed. E-mail: [email protected] (A.F.S.); [email protected] (J.R.) Published 15 January 2010, Science 327, 348 (2010) DOI: 10.1126/science.1183090 This PDF file includes: Materials and Methods SOM Text Figs. S1 to S18 Table S1 References Supporting Online Material Table of Contents Materials and Methods, pages 2-4 Supplemental Text 1-7, pages 5-10 Text 1. Psychotropic Drug Discovery, page 5 Text 2. Dose, pages 5-6 Text 3. Therapeutic Classes of Drugs Induce Correlated Behaviors, page 6 Text 4. Polypharmacology, pages 6-7 Text 5. Pharmacological Conservation, pages 7-9 Text 6. Non-overlapping Regulation of Rest/Wake States, page 9 Text 7. High Throughput Behavioral Screening in Practice, page 10 Supplemental Figure Legends, pages 11-14 Figure S1. Expanded hierarchical clustering analysis, pages 15-18 Figure S2. Hierarchical and k-means clustering yield similar cluster architectures, page 19 Figure S3. Expanded k-means clustergram, pages 20-23 Figure S4. Behavioral fingerprints are stable across a range of doses, page 24 Figure S5. Compounds that share biological targets have highly correlated behavioral fingerprints, page 25 Figure S6. Examples of compounds that share biological targets and/or structural similarity that give similar behavioral profiles, page 26 Figure S7. -
Shichangpu the Perfume Industry and As a Flavoring for Pipe Tobacco
Medicinal Quality The Acorus plant family represents the source of one of the world’s most widely used medicinals. In Egypt, the Chester Beatty Papyrus VI mentioned Acorus as an ingredient for a digestive plaster around 1,300 BC. In ancient Europe, Acorus was a symbol of love, lust and affection. The calamus variety, often referred to as Sweet Flag, was added to absinthe and digestive bitters, used in Shichangpu the perfume industry and as a flavoring for pipe tobacco. In Ayurvedic medicine, Acorus calamus is called Vacha, Acorus gramineus and revered for its ability to transmute Kundalini energy, rejuvenate the brain and stimulate self-expression. In Sanskrit, the term Vacha literally means “speaking,” mirroring a quality that is also expressed in the herb’s Chinese name: the ancient word chang in Shichangpu Heiner Fruehauf originally signifies “splendid expression.” In North America, moreover, Dakota warriors used to apply the root paste to their faces in order to calm the senses and conquer fear when facing an enemy. In ancient China, the herbal classic Shen Nong bencao jing lists Shichangpu as a top grade medicinal, a classification generally reserved for materials that promote spiritual enlightenment and longevity, and are considered safe to consume on a daily basis. The Daozang, China’s collection of esoteric Daoist texts, contains a piece of writing entitled “Changpu zhuan” (A Biography of Acorus), which classicalchinesemedicine.org © 2014 heiner fruehauf classicalpearls.org page 1 shichangpu: acorus gramineus points out that the plant synthesizes the powers of all five Traditional Terroir Considerations elements—exhibiting green leaves, red flowers, white (didao yaocai) joints, yellow core, and black root—and thus represents “a magic elixir for practitioners of immortality rituals.” In India and Europe, it is the calamus variety that is used almost exclusively in herbal remedies and food flavorings. -
HIGHLIGHTS of PRESCRIBING INFORMATION These Highlights Do
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use MEMANTINE and DONEPEZIL ---------------------CONTRAINDICATIONS -------------------- HYDROCHLORIDES EXTENDED-RELEASE Memantine and donepezil hydrochlorides extended-release CAPSULES safely and effectively. See full prescribing capsules are contraindicated in patients with known information for MEMANTINE and DONEPEZIL hypersensitivity to memantine hydrochloride, donepezil HYDROCHLORIDES EXTENDED-RELEASE hydrochloride, piperidine derivatives, or to any excipients CAPSULES. used in the formulation. (4) MEMANTINE and DONEPEZIL HYDROCHLORIDES ------------------WARNINGS AND PRECAUTIONS ---------- extended-release capsules, for oral use • Memantine and donepezil hydrochlorides extended- Initial U.S. Approval: 2014 release is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia. (5.1) ------------------RECENT MAJOR CHANGES ----------------- • Memantine and donepezil hydrochlorides extended- Indications and Usage (1) 07/2016 release may have vagotonic effects on the sinoatrial and Dosage and Administration (2.1, 2.3) 07/2016 atrioventricular nodes manifesting as bradycardia or heart block. (5.2) ------------------INDICATIONS AND USAGE------------------ • Monitor patients for symptoms of active or occult Memantine and donepezil hydrochlorides extended-release gastrointestinal bleeding, especially those at increased capsules are a combination of memantine hydrochloride, an risk for developing ulcers. (5.3) NMDA receptor