Adult Cardiogenic Shock
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When the Heart Kills the Liver: Acute Liver Failure in Congestive Heart Failure
December 14, 2009 Eu Ro PE an JouR nal oF MED I cal RE sEaRcH 541 Eur J Med Res (2009) 14: 541-546 © I. Holzapfel Publishers 2009 WHEn tHE HEaRt KIlls tHE lIvER: acutE lIvER FaIluRE In congEstIvE HEaRt FaIluRE F. H. saner1, M. Heuer1, M. Meyer1, a. canbay2, g. c. sotiropoulos1, a. Radtke1, J. treckmann1, s. Beckebaum1, c. Dohna-schwake2, s. W. oldedamink3, 4, a. Paul1 1Department of general-, visceral- and transplant surgery, university Hospital Essen, germany, 2Department of Pediatric Medicine, university Hospital Essen, germany, 3Department of surgery, university of Maastricht, netherlands, 4Department of surgery, university college london Hospital, ucl, uK Abstract gestive heart failure may be absent [5, 18]. Both, congestive heart failure as a cause of acute liver fail- chronic and acute congestive heart failure can lead to ure is rarely documented with only a few cases. hepatic dysfunction [10, 17]. although there is no although the pathophysiology is poorly under- classic pattern of abnormalities, a cholestatic bio- stood, there is rising evidence, that low cardiac output chemical profile is common, with a mild elevation in with consecutive reduction in hepatic blood flow is a total bilirubin (usually 3 g/dl), a mild elevation in al- main causing factor, rather than hypotension. In the kaline phosphatase and only occasional elevations in setting of acute liver failure due to congestive heart transaminases. another common observation is an in- failure, clinical signs of the latter can be absent, which crease in InR. the presumed causes of hepatic dys- requires an appropriate diagnostic approach. function in congestive heart failure are hepatic con- as a reference center for acute liver failure and liver gestion from venous outflow obstruction and result- transplantation we recorded from May 2003 to De- ing hypertension and decreased oxygen delivery from cember 2007 202 admissions with the primary diag- an impaired cardiac output [10]. -
Shock and Hemodynamic Monitoring
Shock and Hemodynamic Monitoring Matthew Bank, MD, FACS Assistant Professor Hofstra North Shore‐LIJ School of Medicine Director, Surgical Intensive Care Unit North Shore University Hospital I do not have any financial conflicts of interest to disclose for this presentation Shock • Multiple different strategies for classifying shock, but all forms of shock result in impaired oxygen delivery secondary to either one or both: – reduced cardiac output (cardiogenic, septic) OR – loss of effective intravascular volume (hypovolemic, neurogenic, anaphylactic, septic). Septic Shock –Gram Negative • Gram negative septic shock: —Very studied well studied in animal models —Lipopolysaccharide (LPS) in bacterial cell wall binds to LPS binding protein. —LPS‐LBP complex then binds to cell surface CD14 receptors on monocytes and macrophages. —The LPS‐LBP‐CD14 complex then activates cells via Toll‐like receptor‐4 (TLR4). —TLR4 then “activates” cells which produce a cytokine “cascade” of proinflamatory mediators. Septic Shock –Gram Negative • Tumor Necrosis Factor (TNF) – First cytokine produced in response to gram negative sepsis – Principal mediator for acute response to gram negative bacteria – Major source of TNF is from activated macrophages – High levels of TNF predict mortality and can cause apoptosis. Septic Shock –Gram Negative • Interleukin‐1 (IL‐1) – Levels of IL‐1 increase soon after TNF production in gram negative sepsis (second cytokine to be elevated) – IL‐1 produced by macrophages, neutrophils and endothelial cells – IL‐1 increases levels of next proinflammatory cytokines in cascade, IL‐2 and IL‐12. – IL‐1 does NOT cause apoptosis Septic Shock –Gram Negative • Interleukin‐10 – Anti‐inflammatory cytokine – Inhibits production of IL‐12 – Inhibits T‐cell activation Septic Shock –Gram Positive • Gram positive sepsis – Gram positive cell wall components are also known to be involved in septic response – Peptidoglycans – Teichoic Acid – Likely act in a similar manner as LPS, but less potent on a weight bases. -
Chest Pain/Angina Humanresearchwiki Chest Pain/Angina
6/14/2016 Chest Pain/Angina HumanResearchWiki Chest Pain/Angina From HumanResearchWiki Contents 1 Introduction 2 Clinical Priority and Clinical Priority Rationale by Design Reference Mission 3 Initial Treatment Steps During Space Flight 4 Capabilities Needed for Diagnosis 5 Capabilities Needed for Treatment 6 Associated Gap Reports 7 Other Pertinent Documents 8 List of Acronyms 9 References 10 Last Update Introduction Cardiac chest pain, also known as angina, usually occurs secondary to deprivation of oxygen from an area of the heart, often resulting from an inability of the coronary arteries to supply adequate amounts of oxygen during a time of increased demand. The most common cause is atheromatous plaque which obstructs the coronary arteries.[1] NASA crewmembers are extensively screened to rule out coronary artery disease, but progression of previously subclinical and undetectable coronary artery disease may occur during a long duration mission. The initial care of cardiac chest pain is available on the International Space Station (ISS) and the crew is trained to evaluate and treat as needed (ISS Medical Checklist).[2] Clinical Priority and Clinical Priority Rationale by Design Reference Mission One of the inherent properties of space flight is a limitation in available mass, power, and volume within the space craft. These limitations mandate prioritization of what medical equipment and consumables are manifested for the flight, and which medical conditions would be addressed. Therefore, clinical priorities have been assigned to describe which medical conditions will be allocated resources for diagnosis and treatment. “Shall” conditions are those for which diagnostic and treatment capability must be provided, due to a high likelihood of their occurrence and severe consequence if the condition were to occur and no treatment was available. -
Acute Kidney Injury in Cardiogenic Shock: an Updated Narrative Review
Journal of Cardiovascular Development and Disease Review Acute Kidney Injury in Cardiogenic Shock: An Updated Narrative Review Sohrab Singh 1 , Ardaas Kanwar 2, Pranathi R. Sundaragiri 3, Wisit Cheungpasitporn 4 , Alexander G. Truesdell 5, Syed Tanveer Rab 6, Mandeep Singh 7 and Saraschandra Vallabhajosyula 8,* 1 Department of Medicine, The Brooklyn Hospital, Brooklyn, NY 11201, USA; [email protected] 2 Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA; [email protected] 3 Section of Primary Care Internal Medicine, Wake Forest Baptist Health, High Point, NC 27262, USA; [email protected] 4 Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA; [email protected] 5 Virginia Heart/Inova Heart and Vascular Institute, Falls Church, VA 22042, USA; [email protected] 6 Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA; [email protected] 7 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA; [email protected] 8 Section of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27262, USA * Correspondence: [email protected] Abstract: Acute myocardial infarction with cardiogenic shock (AMI-CS) is associated with high mortality and morbidity despite advancements in cardiovascular care. AMI-CS is associated with multiorgan failure of non-cardiac organ systems. Acute kidney injury (AKI) is frequently seen in patients with AMI-CS and is associated with worse mortality and outcomes compared to those without. The pathogenesis of AMI-CS associated with AKI may involve more factors than previously Citation: Singh, S.; Kanwar, A.; understood. -
Approach to Shock.” These Podcasts Are Designed to Give Medical Students an Overview of Key Topics in Pediatrics
PedsCases Podcast Scripts This is a text version of a podcast from Pedscases.com on “Approach to Shock.” These podcasts are designed to give medical students an overview of key topics in pediatrics. The audio versions are accessible on iTunes or at www.pedcases.com/podcasts. Approach to Shock Developed by Dr. Dustin Jacobson and Dr Suzanne Beno for PedsCases.com. December 20, 2016 My name is Dustin Jacobson, a 3rd year pediatrics resident from the University of Toronto. This podcast was supervised by Dr. Suzanne Beno, a staff physician in the division of Pediatric Emergency Medicine at the University of Toronto. Today, we’ll discuss an approach to shock in children. First, we’ll define shock and understand it’s pathophysiology. Next, we’ll examine the subclassifications of shock. Last, we’ll review some basic and more advanced treatment for shock But first, let’s start with a case. Jonny is a 6-year-old male who presents with lethargy that is preceded by 2 days of a diarrheal illness. He has not urinated over the previous 24 hours. On assessment, he is tachycardic and hypotensive. He is febrile at 40 degrees Celsius, and is moaning on assessment, but spontaneously breathing. We’ll revisit this case including evaluation and management near the end of this podcast. The term “shock” is essentially a ‘catch-all’ phrase that refers to a state of inadequate oxygen or nutrient delivery for tissue metabolic demand. This broad definition incorporates many causes that eventually lead to this end-stage state. Basic oxygen delivery is determined by cardiac output and content of oxygen in the blood. -
Septic, Hypovolemic, Obstructive and Cardiogenic Killers
S.H.O.C.K Septic, Hypovolemic, Obstructive and Cardiogenic Killers Jason Ferguson, BPA, NRP Public Safety Programs Head, CVCC Amherst County DPS, Paramedic Centra One, Flight Paramedic Objectives • Define Shock • Review patho and basic components of life • Identify the types of shock • Identify treatments Shock Defined • “Rude unhinging of the machinery of life”- Samuel Gross, U.S. Trauma Surgeon, 1962 • “A momentary pause in the act of death”- John Warren, U.S. Surgeon, 1895 • Inadequate tissue perfusion Components of Life Blood Flow Right Lungs Heart Left Body Heart Patho Review • Preload • Afterload • Baroreceptors Perfusion Preservation Basic rules of shock management: • Maintain airway • Maintain oxygenation and ventilation • Control bleeding where possible • Maintain circulation • Adequate heart rate and intravascular volume ITLS Cases Case 1 • 11 month old female “not acting right” • Found in crib this am lethargic • Airway patent • Breathing is increased; LS clr • Circulation- weak distal pulses; pale and cool Case 1 • VS: RR 48, HR 140, O2 98%, Cap refill >2 secs • Foul smelling diapers x 1 day • “I must have changed her two dozen times yesterday” • Not eating or drinking much Case 1 • IV established after 4 attempts • Fluid bolus initiated • Transported to ED • Received 2 liters of fluid over next 24 hours Hypovolemic Shock Hemorrhage Diarrhea/Vomiting Hypovolemia Burns Peritonitis Shock Progression Compensated to decompensated • Initial rise in blood pressure due to shunting • Initial narrowing of pulse pressure • Diastolic raised -
Shortness of Breath. History of the Present Illness
10/20/2006 Write-Up to be Graded Sarah Broom Chief Complaint: Shortness of breath. History of the Present Illness: Mr.--- is a previously healthy 56-year-old gentleman who presents with a four day history of shortness of breath, hemoptysis, and right-sided chest pain. He works as a truck driver, and the symptoms began four days prior to admission, while he was in Jackson, MS. He drove from Jackson to Abilene, TX, the day after the symptoms began, where worsening of his dyspnea and pain prompted him to go to the emergency room. There, he was diagnosed with pneumonia and placed on Levaquin 500 mg daily and Benzonatate 200 mg TID, which he has been taking for two days with only slight improvement. He then drove from Abilene back to Greensboro, where he resides, and continued to experience shortness of breath, right sided chest pain, and hemoptysis. He presented to an urgent care office in town today, and was subsequently transferred to the Moses Cone ER due to the provider’s suspicion of PE. The right-sided pain is located midway down his ribcage, below the axilla. This pain is sharp, about 7/10 in severity, and worsens with movement and cough. Pressing on the chest does not recreate the pain. He feels that the pain has improved somewhat over the past two days. The hemoptysis has been unchanged since it began; there is not frank blood, but his sputum has been consistently blood-tinged. The blood seems redder at night. The dyspnea has been severe, and it is difficult for him to walk more than across a room. -
KNOW the FACTS ABOUT Heart Disease
KNOW THE FACTS ABOUT Heart Disease What is heart disease? Having high cholesterol, high blood pressure, or diabetes also can increase Heart disease is the leading cause of your risk for heart disease. Ask your death in the United States. More than doctor about preventing or treating these 600,000 Americans die of heart disease medical conditions. each year. That’s one in every four deaths in this country.1 What are the signs and symptoms? The term “heart disease” refers to several The symptoms vary depending on the types of heart conditions. The most type of heart disease. For many people, common type is coronary artery disease, chest discomfort or a heart attack is the which can cause heart attack. Other first sign. kinds of heart disease may involve the Someone having a heart attack may valves in the heart, or the heart may not experience several symptoms, including: pump well and cause heart failure. Some people are born with heart disease. l Chest pain or discomfort that doesn’t go away after a few minutes. l Pain or discomfort in the jaw, neck, Are you at risk? or back. Anyone, including children, can l Weakness, light-headedness, nausea develop heart disease. It occurs when (feeling sick to your stomach), or a substance called plaque builds up in a cold sweat. your arteries. When this happens, your arteries can narrow over time, reducing l Pain or discomfort in the arms blood flow to the heart. or shoulder. Smoking, eating an unhealthy diet, and l Shortness of breath. not getting enough exercise all increase If you think that you or someone you your risk for having heart disease. -
Chest Pain .Pdf
Oklahoma State Department of Health 01-2018Revised CHEST PAIN/PRESSURE Cardiac and non-cardiac conditions cause chest pain including angina, myocardial infarction, hyperventilation, anxiety, muscle strain, pulmonary embolism or dissecting aortic aneurysm. History: Risk factors for heart disease Past history of heart attack Past history of angina; treatment Determine time of onset Quality of pain, sharp, dull, aching, stabbing, burning etc. Location of pain Severity of pain (0-10 scale) Additional symptoms; shortness of breath, unexplained sweating, nausea, radiating to arms, neck or back, rapid heart rate with shortness of breath, cough that may produce blood-streaked sputum, fainting, Anxiety or panic attacks Medications (Nitroglycerin) Medication Allergies (aspirin) Assessment: Obtain vital signs o Listen to heart-rate, rhythm, lungs (for breath sounds) o Check pulse in all extremities and compare Assess for: o Shortness of breath o Skin condition (cold, clammy, sweaty) o Pain with cough or deep breathing o Sudden difficulty speaking, loss of vision, weakness, or paralysis of one side of the body Treatment: If the person is standing, assist them to a sitting or lying position Loosen tight clothing Assist individual with prescribed nitroglycerin tablet. They should not bite or chew nitroglycerin. It should be placed under the tongue to dissolve. Prescribed nitroglycerin may be taken as 1 tablet or spray under the tongue every 5 minutes up to 3 tablets in 15 minutes Encourage individual to chew a 325mg uncoated aspirin Call EMS: Unexplained chest pain lasting more than a few minutes New cases of chest pain Unresolved pain after their normal treatment Pain associated with fever and shortness of breath Reference WebMD. -
Education Heart Palpitations
Education Heart Palpitations What are palpitations? Palpitations are an uncomfortable awareness of your heartbeat. You may feel that your heart is beating harder or faster than usual or that it is skipping a beat or two. Palpitations are common and often normal. They are a symptom, not a disease. However, it is important to determine their cause. How do they occur? Palpitations may be brought on by: exercise stress, anxiety, or fear smoking alcohol too much caffeine from coffee, colas, or tea anemia heart problems, such as mitral valve prolapse a thyroid problem medicines, such as diet pills and decongestants, or overdoses of such medicines as theophylline and antidepressants premenstrual syndrome (PMS) a lack of certain vitamins or minerals low blood sugar, or an insulin reaction in diabetics. What are the symptoms? Symptoms may include: thumping, pounding, or racing sensation in your chest fluttering sensation in your chest feeling of irregular beating or skipped beats. How are they diagnosed? Your health care provider will review your symptoms and examine you. You may have an electrocardiogram (ECG) or other tests to help find the cause. You may be given a heart monitor to wear at home. You may have an ultrasound test of the heart called an echocardiogram or an exercise stress test to see if heart problems are causing the palpitations. How are they treated? Treatment of palpitations depends on the cause. Most often, no treatment is needed because the heart is otherwise normal. Drinking less coffee or alcohol, or none at all, may be all you need to do. -
Cardiogenic Shock in Right Ventricular Thermodilution and Pacing
Arch Emerg Med: first published as 10.1136/emj.4.2.107 on 1 June 1987. Downloaded from Archives of Emergency Medicine, 1987, 4, 107-110 CASE REPORT Cardiogenic shock in right ventricular infarction managed with a combined thermodilution and pacing pulmonary artery flotation catheter J. D. EDWARDS, R. WILKINS & H. GIBSON Intensive Care Unit, University Hospital of South Manchester, Manchester, England SUMMARY When cardiogenic shock complicates right venticular infarction it is widely appreciated that rational therapy can only be achieved by use of plasma volume expansion and inotropic agents guided by invasive monitoring (Cohn et al., 1974). In these cases, there by copyright. is a high incidence of symptomatic heart block and serious atrial and ventricular dysrhythmias (Cohn, 1979). Thus, venous access may be required for monitoring, pacing, infusion of fluid, and vasoactive or antiarrhythmic drugs. A case of right ventricular infarction complicated by cardiogenic shock, heart block, multiple arrhyth- mias and severe hypoxaemic respiratory failure is described. Technical problems in venous access were encountered and overcome by the use of a single multi-purpose catheter for haemodynamic monitoring, infusion of drugs and fluids and passage of a http://emj.bmj.com/ pacing wire. We believe that this is the first description of the use of such a catheter in the United Kingdom, although the use of a multi-purpose pulmonary artery flotation catheter with fixed pacing electrodes has been described before (Zaidan & Freniere, 1983). on September 29, 2021 by guest. Protected CASE REPORT The patient was a 74-year-old female managed on the Coronary Care and Intensive Care Units of the University Hospital of South Manchester, England. -
Chest Pain (Angina) What You Can Expect at the Hospital
PATIENT EDUCATION Chest Pain (Angina) What You Can Expect at the Hospital Chest Pain When To Call Your Nurse Your doctor wants you to have some tests to Call your nurse right away if you have any find out the cause of your recent heart event. of the following: These tests can tell your doctor what caused chest pain or pressure your pain. pain moving to arm, neck or jaw Angina (chest pain) happens when not enough blood flows to your heart muscle. This is a unexplained nausea (upset stomach), pressure or tightness in the chest. It is usually heartburn or both brought on by stress and goes away when the shortness of breath. stressful activity stops. Activity At the Hospital You will stay in bed until the EKG and blood You will be taken to a unit where your heart test results are known. You may be able to use rhythm will be checked with a the bathroom if you are able to be out of bed. heart monitor. A nurse will ask you for your health history You will slowly increase your activity from and do a physical exam. resting to walking. Your doctor may request cardiac rehabilitation. You will have an electrocardiogram (EKG). This test records the electrical activity of Food and Drink your heart. Your doctor will order heart-healthy food low — You will have small electrodes (discs) in saturated fat, salt and cholesterol. placed on your chest. You will not be able to have caffeine. — The electrical “waves” are shown on a This includes regular and decaffeinated coffee, monitor and printed on paper.