Treating Prostate Cancer If You've Been Diagnosed with Prostate Cancer, Your Cancer Care Team Will Discuss Your Treatment Options with You
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Is There Anything New in Prostate Cancer Screening?
IS THERE ANYTHING NEW IN PROSTATE CANCER SCREENING? ANDREW M.D. WOLF, MD, FACP ASSOCIATE PROFESSOR OF MEDICINE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE No financial disclosures Case Presentation 62 yo white man without significant past medical history presents for annual preventive visit. He has no family history of prostate cancer. He has mild urinary hesitancy and his prostate is mildly enlarged without induration or nodules. His PSA has been gradually rising: - 2011: 2.35 - 2013: 2.17 - 2017: 3.75 - 2019: 4.51 Where do we go from here? What’s New in Prostate Cancer Screening? Key Questions • Do we have any new evidence for or against screening? • Do we have anything better than the PSA? • What about the good old digital rectal exam? • Are we doing any better identifying who needs to be treated? • What do the experts recommend? Prostate Cancer Incidence & Mortality Over the Decades Source: Seer 9 areas & US Mortality Files (National Center for Health Statistics, CDC, Feb 2018 CA Cancer J Clin 2019;69:7-34. Do we have any new evidence for or against prostate cancer screening? Is Prostate Screening Still Controversial? ERSPC Results • Prostate cancer death rate 27% lower in screened group (p = 0.0001) at 13 yrs • Number needed to screen to save 1 life: 781 • NNS to prevent 1 case of metastatic cancer: ~350 • Number needed to diagnose to save 1 life: 27 • Major issue of over-diagnosis & over-treatment Schroder FH, et al. Lancet 2014;384: 2027–2035 • Controlled for differences in study design • Adjusted for lead-time • Both studies led to a ~ 25-32% reduction in prostate cancer mortality with screening compared with no screening Ann Intern Med 2017;167:449-455 • 415,000 British men 50-69 randomized to a single offer to screen vs usual care (info sheet on request) • One-time screen & then followed for 10 yrs • Men dx’d with prostate cancer randomized to treatment vs active surveillance JAMA 2018;319(9):883-895. -
Institute for Clinical and Economic Review
INSTITUTE FOR CLINICAL AND ECONOMIC REVIEW FINAL APPRAISAL DOCUMENT BRACHYTHERAPY & PROTON BEAM THERAPY FOR TREATMENT OF CLINICALLY-LOCALIZED, LOW-RISK PROSTATE CANCER December 22, 2008 Senior Staff Daniel A. Ollendorf, MPH, ARM Chief Review Officer Julia Hayes, MD Lead Decision Scientist Pamela McMahon, PhD Sr. Decision Scientist Steven D. Pearson, MD, MSc President, ICER Associate Staff Michelle Kuba, MPH Sr. Technology Analyst Angela Tramontano, MPH Research Assistant © ICER, 2008 1 CONTENTS About ICER .................................................................................................................................. 3 Acknowledgments ...................................................................................................................... 4 Executive Summary .................................................................................................................... 5 Evidence Review Group Deliberation.................................................................................. 15 ICER Integrated Evidence Rating.......................................................................................... 21 Evidence Review Group Members........................................................................................ 24 Appraisal Overview.................................................................................................................. 28 Background ............................................................................................................................... -
Prostate Cancer Causes, Risk Factors, and Prevention Risk Factors
cancer.org | 1.800.227.2345 Prostate Cancer Causes, Risk Factors, and Prevention Risk Factors A risk factor is anything that increases your chances of getting a disease such as cancer. Learn more about the risk factors for prostate cancer. ● Prostate Cancer Risk Factors ● What Causes Prostate Cancer? Prevention There is no sure way to prevent prostate cancer. But there are things you can do that might lower your risk. Learn more. ● Can Prostate Cancer Be Prevented? Prostate Cancer Risk Factors A risk factor is anything that raises your risk of getting a disease such as cancer. Different cancers have different risk factors. Some risk factors, like smoking, can be changed. Others, like a person’s age or family history, can’t be changed. But having a risk factor, or even several, does not mean that you will get the disease. 1 ____________________________________________________________________________________American Cancer Society cancer.org | 1.800.227.2345 Many people with one or more risk factors never get cancer, while others who get cancer may have had few or no known risk factors. Researchers have found several factors that might affect a man’s risk of getting prostate cancer. Age Prostate cancer is rare in men younger than 40, but the chance of having prostate cancer rises rapidly after age 50. About 6 in 10 cases of prostate cancer are found in men older than 65. Race/ethnicity Prostate cancer develops more often in African-American men and in Caribbean men of African ancestry than in men of other races. And when it does develop in these men, they tend to be younger. -
Profiling Prostate Cancer Therapeutic Resistance
International Journal of Molecular Sciences Review Profiling Prostate Cancer Therapeutic Resistance Cameron A. Wade 1 and Natasha Kyprianou 1,2,3,* 1 Departments of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, KY 40536, USA; [email protected] 2 Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky, KY 40536, USA 3 Department of Toxicology & Cancer Biology, University of Kentucky College of Medicine, Lexington, Kentucky, KY 40536, USA * Correspondence: [email protected]; Tel.: +1-859-323-9812; Fax: +1-859-323-1944 Received: 1 March 2018; Accepted: 16 March 2018; Published: 19 March 2018 Abstract: The major challenge in the treatment of patients with advanced lethal prostate cancer is therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy. Overriding this resistance requires understanding of the driving mechanisms of the tumor microenvironment, not just the androgen receptor (AR)-signaling cascade, that facilitate therapeutic resistance in order to identify new drug targets. The tumor microenvironment enables key signaling pathways promoting cancer cell survival and invasion via resistance to anoikis. In particular, the process of epithelial-mesenchymal-transition (EMT), directed by transforming growth factor-β (TGF-β), confers stem cell properties and acquisition of a migratory and invasive phenotype via resistance to anoikis. Our lead agent DZ-50 may have a potentially high efficacy in advanced metastatic castration resistant prostate cancer (mCRPC) by eliciting an anoikis-driven therapeutic response. The plasticity of differentiated prostate tumor gland epithelium allows cells to de-differentiate into mesenchymal cells via EMT and re-differentiate via reversal to mesenchymal epithelial transition (MET) during tumor progression. -
CASODEX (Bicalutamide)
HIGHLIGHTS OF PRESCRIBING INFORMATION • Gynecomastia and breast pain have been reported during treatment with These highlights do not include all the information needed to use CASODEX 150 mg when used as a single agent. (5.3) CASODEX® safely and effectively. See full prescribing information for • CASODEX is used in combination with an LHRH agonist. LHRH CASODEX. agonists have been shown to cause a reduction in glucose tolerance in CASODEX® (bicalutamide) tablet, for oral use males. Consideration should be given to monitoring blood glucose in Initial U.S. Approval: 1995 patients receiving CASODEX in combination with LHRH agonists. (5.4) -------------------------- RECENT MAJOR CHANGES -------------------------- • Monitoring Prostate Specific Antigen (PSA) is recommended. Evaluate Warnings and Precautions (5.2) 10/2017 for clinical progression if PSA increases. (5.5) --------------------------- INDICATIONS AND USAGE -------------------------- ------------------------------ ADVERSE REACTIONS ----------------------------- • CASODEX 50 mg is an androgen receptor inhibitor indicated for use in Adverse reactions that occurred in more than 10% of patients receiving combination therapy with a luteinizing hormone-releasing hormone CASODEX plus an LHRH-A were: hot flashes, pain (including general, back, (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of pelvic and abdominal), asthenia, constipation, infection, nausea, peripheral the prostate. (1) edema, dyspnea, diarrhea, hematuria, nocturia, and anemia. (6.1) • CASODEX 150 mg daily is not approved for use alone or with other treatments. (1) To report SUSPECTED ADVERSE REACTIONS, contact AstraZeneca Pharmaceuticals LP at 1-800-236-9933 or FDA at 1-800-FDA-1088 or ---------------------- DOSAGE AND ADMINISTRATION ---------------------- www.fda.gov/medwatch The recommended dose for CASODEX therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening). -
Neuroendocrine Differentiation of Prostatic Adenocarcinoma
J Lab Med 2019; 43(2): 123–126 Laboratory Case Report Cátia Iracema Morais*, João Lobo, João P. Barreto, Cláudia Lobo and Nuno D. Gonçalves Neuroendocrine differentiation of prostatic adenocarcinoma – an important cause for castration-resistant disease recurrence https://doi.org/10.1515/labmed-2018-0190 awareness of this entity is crucial due to its underdiagno- Received December 3, 2018; accepted December 12, 2018; previously sis and adverse prognosis. published online February 15, 2019 Keywords: carcinoma; castration-resistant (D064129); cell Abstract transformation; neoplastic (D002471); neuroendocrine (D018278); prostate (D011467); prostatic neoplasms. Background: Neuroendocrine differentiation of prostatic carcinoma is a rare entity associated with metastatic castration-resistant disease. Among useful biomarkers of neuroendocrine differentiation, chromogranin A, sero- Introduction tonin, synaptophysin and neuron-specific enolase stand out, while total prostate-specific antigen (PSA) levels are Neuroendocrine prostatic carcinoma is a rare and often low or undetectable. underdiagnosed histologic subtype. Despite the low Case presentation: We report a case of prostatic adenocar- incidence rate of primary neuroendocrine prostatic cinoma recurrence after a 6-year disease-free follow-up, in carcinoma (which represents under 1% of all prostate which increased serum chromogranin A levels and unde- cancers at diagnosis), 30–40% of patients who develop tectable total PSA provided a prompt indication of neu- metastasized castration-resistant -
U.S. Cancer Statistics: Male Urologic Cancers During 2013–2017, One of Three Cancers Diagnosed in Men Was a Urologic Cancer
Please visit the accessible version of this content at https://www.cdc.gov/cancer/uscs/about/data-briefs/no21-male-urologic-cancers.htm December 2020| No. 21 U.S. Cancer Statistics: Male Urologic Cancers During 2013–2017, one of three cancers diagnosed in men was a urologic cancer. Of 302,304 urologic cancers diagnosed each year, 67% were found in the prostate, 19% in the urinary bladder, 13% in the kidney or renal pelvis, and 3% in the testis. Incidence Male urologic cancer is any cancer that starts in men’s reproductive or urinary tract organs. The four most common sites where cancer is found are the prostate, urinary bladder, kidney or renal pelvis, and testis. Other sites include the penis, ureter, and urethra. Figure 1. Age-Adjusted Incidence Rates for 4 Common Urologic Cancers Among Males, by Racial/Ethnic Group, United States, 2013–2017 5.0 Racial/Ethnic Group Prostate cancer is the most common 2.1 Hispanic Non-Hispanic Asian or Pacific Islander urologic cancer among men in all 6.3 Testis Non-Hispanic American Indian/Alaska Native racial/ethnic groups. 1.5 Non-Hispanic Black 7.0 Non-Hispanic White 5.7 All Males Among non-Hispanic White and Asian/Pacific Islander men, bladder 21.8 11.4 cancer is the second most common and 29.4 kidney cancer is the third most Kidney and Renal Pelvis 26.1 common, but this order is switched 23.1 22.8 among other racial/ethnic groups. 18.6 • The incidence rate for prostate 14.9 cancer is highest among non- 21.1 Urinary Bladder 19.7 Hispanic Black men. -
Review Committee News—Urology
Review Committee News—Urology • Definitions of Board Pass Rates This is a reminder that programs will be cited for poor performance on the American Board of Urology examination if they average more than two standard deviations above the mean in failure rates over a five-year period. The RRC will only look at first-time test takers on Part One of the Board’s Qualifying Examination. The application of this standard began with programs reviewed after July 1, 2010. • Logging Ultrasound Procedures To define the current resident experience in performing urologic ultrasound procedures and to track this experience over time, the Urology Review Committee would like residents to log these cases starting July 1, 2012. Ultrasound cases include commonly performed procedures such as transrectal ultrasound (TRUS) with prostate biopsy, and non-TRUS biopsy procedures such as renal, pelvic, scrotal and penile ultrasound cases. The Review Committee is particularly interested in tracking resident involvement in non-TRUS biopsy ultrasound procedures. While TRUS-prostate biopsy will remain an index case with a minimum number required (25), there will be no minimum number of cases required for non- prostate ultrasound procedures. We ask that residents use one of the following CPT codes when logging these procedures: Category CPT code Scrotal 76870 Renal Retroperitoneal, limited (kidney only) 76775 Retroperitoneal, complete (both kidney and bladder) 76770 Transplant kidney ultrasound 76776 US guidance, intraoperative (e.g. during partial nephrectomy) 76998 US -
Trends in Targeted Prostate Brachytherapy: from Multiparametric MRI to Nanomolecular Radiosensitizers
Nicolae et al. Cancer Nano (2016) 7:6 DOI 10.1186/s12645-016-0018-5 REVIEW Open Access Trends in targeted prostate brachytherapy: from multiparametric MRI to nanomolecular radiosensitizers Alexandru Mihai Nicolae1, Niranjan Venugopal2 and Ananth Ravi1* *Correspondence: [email protected] Abstract 1 Odette Cancer Centre, The treatment of localized prostate cancer is expected to become a significant Sunnybrook Health Sciences Centre, 2075 Bayview Ave, problem in the next decade as an increasingly aging population becomes prone to Toronto, ON M4N3M5, developing the disease. Recent research into the biological nature of prostate cancer Canada has shown that large localized doses of radiation to the cancer offer excellent long- Full list of author information is available at the end of the term disease control. Brachytherapy, a form of localized radiation therapy, has been article shown to be one of the most effective methods for delivering high radiation doses to the cancer; however, recent evidence suggests that increasing the localized radiation dose without bound may cause unacceptable increases in long-term side effects. This review focuses on methods that have been proposed, or are already in clinical use, to safely escalate the dose of radiation within the prostate. The advent of multiparametric magnetic resonance imaging (mpMRI) to better identify and localize intraprostatic tumors, and nanomolecular radiosensitizers such as gold nanoparticles (GNPs), may be used synergistically to increase doses to cancerous tissue without the -
High Dose-Rate Brachytherapy of Localized Prostate Cancer Converts
Open access Original research J Immunother Cancer: first published as 10.1136/jitc-2020-000792 on 24 June 2020. Downloaded from High dose- rate brachytherapy of localized prostate cancer converts tumors from cold to hot 1,2,3 1 1 1 Simon P Keam , Heloise Halse, Thu Nguyen, Minyu Wang , Nicolas Van Kooten Losio,1 Catherine Mitchell,4 Franco Caramia,3 David J Byrne,4 Sue Haupt,2,3 Georgina Ryland,4 Phillip K Darcy,1,2 Shahneen Sandhu,5 2,4 2,3 6 1,2 Piers Blombery, Ygal Haupt, Scott G Williams, Paul J Neeson To cite: Keam SP, Halse H, ABSTRACT organized immune infiltrates and signaling changes. Nguyen T, et al. High dose- rate Background Prostate cancer (PCa) has a profoundly Understanding and potentially harnessing these changes brachytherapy of localized immunosuppressive microenvironment and is commonly will have widespread implications for the future treatment prostate cancer converts tumors immune excluded with few infiltrative lymphocytes and of localized PCa, including rational use of combination from cold to hot. Journal for low levels of immune activation. High- dose radiation radio- immunotherapy. ImmunoTherapy of Cancer 2020;8:e000792. doi:10.1136/ has been demonstrated to stimulate the immune system jitc-2020-000792 in various human solid tumors. We hypothesized that localized radiation therapy, in the form of high dose- INTRODUCTION ► Additional material is rate brachytherapy (HDRBT), would overcome immune Standard curative- intent treatment options published online only. To view suppression in PCa. for localized prostate cancer (PCa) include please visit the journal online Methods To investigate whether HDRBT altered prostate radical prostatectomy or radiotherapy.1 (http:// dx. -
Cancer Treatment and Survivorship Facts & Figures 2019-2021
Cancer Treatment & Survivorship Facts & Figures 2019-2021 Estimated Numbers of Cancer Survivors by State as of January 1, 2019 WA 386,540 NH MT VT 84,080 ME ND 95,540 59,970 38,430 34,360 OR MN 213,620 300,980 MA ID 434,230 77,860 SD WI NY 42,810 313,370 1,105,550 WY MI 33,310 RI 570,760 67,900 IA PA NE CT 243,410 NV 185,720 771,120 108,500 OH 132,950 NJ 543,190 UT IL IN 581,350 115,840 651,810 296,940 DE 55,460 CA CO WV 225,470 1,888,480 KS 117,070 VA MO MD 275,420 151,950 408,060 300,200 KY 254,780 DC 18,750 NC TN 470,120 AZ OK 326,530 NM 207,260 AR 392,530 111,620 SC 143,320 280,890 GA AL MS 446,900 135,260 244,320 TX 1,140,170 LA 232,100 AK 36,550 FL 1,482,090 US 16,920,370 HI 84,960 States estimates do not sum to US total due to rounding. Source: Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute. Contents Introduction 1 Long-term Survivorship 24 Who Are Cancer Survivors? 1 Quality of Life 24 How Many People Have a History of Cancer? 2 Financial Hardship among Cancer Survivors 26 Cancer Treatment and Common Side Effects 4 Regaining and Improving Health through Healthy Behaviors 26 Cancer Survival and Access to Care 5 Concerns of Caregivers and Families 28 Selected Cancers 6 The Future of Cancer Survivorship in Breast (Female) 6 the United States 28 Cancers in Children and Adolescents 9 The American Cancer Society 30 Colon and Rectum 10 How the American Cancer Society Saves Lives 30 Leukemia and Lymphoma 12 Research 34 Lung and Bronchus 15 Advocacy 34 Melanoma of the Skin 16 Prostate 16 Sources of Statistics 36 Testis 17 References 37 Thyroid 19 Acknowledgments 45 Urinary Bladder 19 Uterine Corpus 21 Navigating the Cancer Experience: Treatment and Supportive Care 22 Making Decisions about Cancer Care 22 Cancer Rehabilitation 22 Psychosocial Care 23 Palliative Care 23 Transitioning to Long-term Survivorship 23 This publication attempts to summarize current scientific information about Global Headquarters: American Cancer Society Inc. -
PROSTATE and TESTIS PATHOLOGY “A Coin Has Two Sides”, the Duality of Male Pathology
7/12/2017 PROSTATE AND TESTIS PATHOLOGY “A Coin Has Two Sides”, The Duality Of Male Pathology • Jaime Furman, M.D. • Pathology Reference Laboratory San Antonio. • Clinical Assistant Professor Departments of Pathology and Urology, UT Health San Antonio. Source: http://themoderngoddess.com/blog/spring‐equinox‐balance‐in‐motion/ I am Colombian and speak English with a Spanish accent! o Shannon Alporta o Lindsey Sinn o Joe Nosito o Megan Bindseil o Kandace Michael o Savannah McDonald Source: http://www.taringa.net/posts/humor/7967911/Sindrome‐de‐la‐ Tiza.html 1 7/12/2017 The Prostate Axial view Base Apex Middle Apex Sagittal view Reference: Vikas Kundra, M.D., Ph.D. , Surena F. Matin, M.D. , Deborah A. Kuban, M.Dhttps://clinicalgate.com/prostate‐cancer‐4/ Ultrasound‐guided biopsy following a specified grid pattern of biopsies remains the standard of care. This approach misses 21% to 28% of prostate cancers. JAMA. 2017;317(24):2532‐2542. http://www.nature.com/nrurol/journal/v10/n12/abs/nrurol.2013.195.html Prostate Pathology Inflammation / granulomas Categories Adenosis, radiation, atrophy seminal vesicle Biopsy Benign TURP HGPIN Unsuspected carcinoma is seen in 12% of Atypical IHC TURP cases. glands Prostatectomy Subtype, Gleason, Malignant fat invasion, vascular invasion Other malignancies: sarcomas, lymphomas Benign Prostate Remember Malignant Glands Lack Basal Glands Cells Basal cells Secretory cells Stroma 2 7/12/2017 Benign Prostatic Lesions Atrophy Corpora amylacea (secretions) Seminal Vesicle Acute inflammation GMS Basal cell hyperplasia Basal cell hyperplasia Granulomas (BPH) (BPH) coccidiomycosis Mimics of Prostate Carcinoma Atrophy. Benign Carcinoma with atrophic features Prostate Carcinoma 1. Prostate cancer is the most common, noncutaneous cancer in men in the United States.