Fever: Systemic Response to

Availa®Zn Impacts Inflammation-Related Rectal Temperature Response

LAYERS SALMONELLA IMMUNITY – CHINA is part of the body’s natural response to Figure 1. Effect of Availa-Zn on -1β Response to inflammatory stimuli when occurs. SalmonellaSerum Typhimurium Interleukin LPS Injection-1β in LayersConcentration Upon recognition, sentinel cells, such as , secrete IL-1, IL-6 and TNF-a d 5 that trigger changes in body temperature. Controla Sulfateb Availa®Znc 85 85 z Fever enhances some components of the 81.1z 81.6 72.6y 75 75 : 70.2y μL μL 64.0y • migration and chemotaxis 65 65 /100 • /100 pg Dendritic cell maturation pg 55 55 x 1β, • 1β, 50.8 - Lymphocyte circulation - IL IL • 43.3yz 43.8z Promotion of IL-2 secretion 45 y 41.9 40.8 45 • Survival of T-cells by inhibition of apoptosis 40.3 39.4 (programmed cell death) 35 35 3 h 12 h 3 h 12 h LPSd In a recent study, Salmonella Typhimurium LPS Saline a Control,a noControl, added no addedZn; Basal Zn; Basal Zn Zn levels: levels: 3 to 8 8 wk wk(35 (35 ppm), ppm), 9 to 18 9 wkto (3118 ppm),wk (31 19 toppm), 45 wk (29 ppm) and 19 to 45 wk46 to (29 65 wkppm)(31 ppm)and 46 to 65 wk (31 ppm) inoculum or saline was administered to layers. b b Supplemented with 60 ppm Zn from ZnSO4 Supplementedc with 60 ppm Zn from ZnSO4 c Supplemented with 60 ppm Zn from Availa-Zn zinc amino acid complex Supplementedd : with 60 ppm Sigma Zn Chemical, from Availa-Zn St. Louis, zincMissouri; amino 1.0 μg/mL acid reconstitutedcomplex in saline water concentration, IL-1b, was greatest at d Lipopolysaccharide:xyz Within a challenge Sigma and timeChemical, period, means St. Louis, lacking Missouri;a common superscript 1.0 μg/mL letter reconstituted differ, P < 0.05 in saline water PL - 188 xyz Within a challengeCheng and Guo and. 2004. time Asian period,-Aust. means J. Anim. lackingSci. 17:1717 a common superscript letter differ, P < 0.05 3 h and lowest at 12 h for birds fed zinc from Cheng and Guo. 2004. Asian-Aust. J. Anim. Sci. 17:1717 Availa-Zn. Subsequently, rectal temperature ZINPRO AND MANPRO FOR PERFORMANCE AND IMMUNITY peaked earlier and returned to an inflammatory Figure 2. Effect of ZINPRO® and MANPRO® ® on Immune Response® to neutral state more rapidly (Figure 1). Effect Of ZINPRO And MANPRO IBRVOn Challenge Immune Response To IBRV Challenge In another study, beef calves were challenged with infectious bovine rhinotracheitis . In 10 z response to infection, calves receiving ZINPRO® z Oxidesa 8 z z ZINPRO + zinc methionine and MANPRO® manganese z b 6 y MANPRO methionine exhibited a more efficient immune z y y 4 y response. Changes in fever response returned y to baseline more rapidly (Figure 2), DMI 2 y intake change was minimized and subsequent 0 body weights remained higher during the Change, % Rectal Temperature -2 inflammatory process. 1 4 7 10 13 16 19 22 25 28 Days Following IBRV Challenge

a Zinc oxide (50a ppm) and manganese oxide (40 ppm) b Zinc oxide (50 mg Zn/kg) and manganese oxide (40 mg Mn/kg) ZINPRO zincb methionineZINPRO zinc methionine (50 ppm)(50 and mg Zn/kg) MANPRO and MANPRO manganese manganese methionine methionine (40 (40 mg Mnppm)/kg) yz Points within yza Pointssingle within time a single period time lackingperiod lacking a common a common superscript letter letter differ, Pdiffer, < 0.05 P < 0.05 BR Chirase- 72 and Greene.Chirase and2001. Greene. Anim 2001. Feed Anim FeedSci. Sci.and and Tech. Tech. 93:217-22893:217-228 CONCLUSIONS By providing zinc from Availa-Zn, the fever response process is initiated more rapidly and fever subsides sooner. This illustrates a more efficient immune response that minimizes the energy expenditure associated with systemic infection.

Performance Trace Minerals Can Help You Manage Inflammation

Inflammation-P7