Supporting Information

© Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2007

Supporting Information

Supplementary Table 1 Table 1 Structure Similarity Scitegic Biospectra* Protein COSTART MedDRA Descriptor Measure Keys* Co-invest* Co-citation* Co-citation* ISIS keys Ward NA 4.68e-070 0.05605 2.443e-005 0.0006525 ISIS keys Cosine NA NA 9.095e-219 NA 7.568e-137 ISIS keys Euclidean NA NA NA 1.799e-086 1.27e-115

Table 2 Structure Similarity ISIS Biospectra* Protein COSTART MedDRA Descriptor Measure Keys* Co-invest* Co-citation* Co-citation* Scitegic keys Ward NA 0.04715 NA NA NA Scitegic keys Cosine NA NA NA NA NA Scitegic keys Euclidean NA NA NA NA NA

Table 3 Structure Similarity ISIS Scitegic Protein COSTART MedDRA Descriptor Measure Keys* Keys* Co-invest* Co-citation* Co-citation* Biospectra Ward 4.68e-070 0.04715 4.272e-108 3.68e-118 0.0002087 Biospectra Cosine NA NA 5.34e-015 3.125e-069 9.523e-006 Biospectra Euclidean NA NA 9.533e-122 0+ 2.695e-165

Table 4 Biospectra pair- Cosine ISIS Scitegic Protein COSTART MedDRA wise distances CCS± Keys Keys Co-invest Co-citation Co-citation 565,516 (100%) CCS > 0 NA NA 5.34e-015 3.125e-069 9.523e-006 452,388 (80.0%) CCS > 0.1 NA NA 0.1186 1.77e-053 4.50e-039 60,098 (10.8%) CCS > 0.3 NA NA 1.752e-070 0.03791 7.701e-016 25,862 (4.6%) CCS > 0.5 2.999e-038 1.174e-118 1.194e-066 1.702e-091 3.277e-062 5,076 (0.90%) CCS > 0.7 2.716e-012 3.855e-011 3.465e-005 5.936e-018 2.563e-007

Table 5 ISIS key pair- Cosine Biospectra Scitegic Protein COSTART MedDRA wise distances CCS± Keys Co-invest Co-citation Co-citation 565,516 (100%) CCS > 0 NA NA 9.095e-219 NA 7.568e-137 214,537 (37.9%) CCS > 0.5 NA NA NA 9.938-192 NA 41,792 (7.4%) CCS > 0.65 0.1876 NA NA 2.034e-142 6.262e-244 18,471 (3.3%) CCS > 0.70 3.093e-046 NA NA 1.812e-168 1.457e-163 1512 (0.27%) CCS > 0.85 3.771e-008 6.723e-085 7.661e-007 3.516e-015 1.819e-013

Table 6 Scitegic pair- Cosine Biospectra ISIS Protein COSTART MedDRA wise distances CCS± Keys Co-invest Co-citation Co-citation 565,516 (100%) CCS > 0 NA NA NA NA NA 375,629 (66.4%) CCS > 0.2 NA NA NA NA NA 27,631 (4.9%) CCS > 0.3 7.963e-025 NA NA 6.169e-300 NA 8187 (1.5%) CCS > 0.35 2.048e-031 NA 3.006e-163 2.951e-163 2.709e-177 3834 (0.68%) CCS > 0.4 2.395e-010 5.446e-215 1.077e-045 1.851e-059 9.671e-080

* Statistical significance (p-values) of 565,516 pair wise distance comparisons of 1064 using three molecular structure descriptors (biospectra, ISIS and Scitegic keys) and three system-wide -effect descriptors (protein co-investigation frequency, COSTART and MedDRA co-citation). + Statistical significance (p = 9.436e- 291) was obtained for 563,392 (99.6%) of the comparisons. ± Confidence in cluster similarity [0 (least similar) to 1(most similar)].

Supplementary Figure 1

Supplementary Figure 1a. 1064 medicines/1205 medicines

1064 Medicines monohydrate Flumethasone Pivalate Acetate Beclomethasone Dipropionate Propionate Pivalate Propionate Furoate etabonate Flurandrenolide Acetonide 4-Hydroxyestrone 2-Hydroxyestradiol 4-Hydroxyestradiol 1,3,5(10)-Estratrien-2,3-Diol-17-One 2-Methyl Ether 2-Methoxyestradiol 17Beta- 17-Hemisuccinate Podocarpic Acid Dehydrocholic Acid Ursodiol Alprostadil Dinoprostone Allethrin Triacetin Loxoprofene Quinic Acid Succinic Anhydride Mupirocin Mycophenolate Mofetil HCl Pravastatin Artemether Piperonyl Butoxide SC-41930 SC-53228 11-Beta,17-Alpha-Dihydroxypregn-4-Ene-3,20-Dione 17Alpha-Hydroxypregnenolone 4-Androsten-4-Ol-3,17-Dione 17Alpha-Hydroxyprogesterone Medroxyprogesterone Oleanolic Acid Norgestrel 5-Cholesten-3Beta-Ol-7-One Calcifediol 19-Hydroxyandrost-4-Ene-3,17-Dione Uvaol 17 Alpha-Dihydroequilin Norethindrone Norethynodrel Dydrogesterone Ethynodiol Diacetate Acetate Melengestrol Acetate Medroxyprogesterone Acetate Desoxycorticosterone Pivalate Hydroxyprogesterone Caproate Testosterone Decanoate All-Trans-Retinol Ubidecarenone Clofibrate Ciprofibrate Bromopropylate Fenofibrate Deltamethrin Cyfluthrin Lambda-Cyhalothrin Fenpropathrin Fenvalerate Chloroxylenol Bis(2-Hydroxy-5-Chlorophenyl) Diflunisal HCl Dicofol Lindane Indomethacin Cerivastatin Sodium 1,5-Isoquinolinediol 5,7-Dichlorokynurenic Acid FPL 64176 Bisacodyl HCl RG-13022 Ethacrynic Acid Butylparaben Ethylparaben Gemfibrozil Octyl Salicylate Dienestrol Diacetate Phenothrin Monobenzone Citrinin Dehydroacetic Acid Dithianon 1,4-Benzoquinone Menadione Mandelic Acid Pyromellitic Acid 2-Tert-Butyl-4-Hydroxyanisole 3-tert-Butyl-4-hydroxyanisole Guaiacol Propofol Probucol Oxybenzone Erbstatin Analog Sodium Methylparaben Diacerein Aloe-Emodin Emodin Butein Resorcinol Aurintricarboxylic Acid Trisalicylic Acid Amygdalin Trihydrate Arbutin Guaifenesin Aloin Mangiferin Rutin Aflatoxin B1 Aflatoxin G1 Etoposide Teniposide Podophyllotoxin Cromolyn Sodium Methoxsalen Gallocatechin Gallate, (-)- Gossypetin Hematein PCO 400 O-Cresolphthalein Bromadiolon Amifostine CGP 35348 Alendronate Sodium Pamidronate Ibandronate sodium Carmustine Deferoxamine Mesylate Ifosfamide Busulphan Acamprosate Calcium Mesna Sodium 0155098-0000 Omethoate Coumaphos Chlorpyriphos-Methyl Fenchlorphos Leptophos Profenofos Bromfenvinphos Tetrachlorvinphos Fensulfothion Isomalathion Tetraethyl Pyrophosphate Phorate Trichlorfon Fosfomycin Tromethamine Risedronate Sodium Clodronic acid disodium salt Tiludronate Disodium DL-Thiorphan Actarit Aminohippuric Acid o-Iodohippuric Acid Aspartame Related Compound A H-Tyr-Tyr-OH Epibestatin HCl Acetaminophen Methyl Anthranilate HCl 4-(N-[3-Chlorophenyl]-Carbamoyloxy)-2-Butynyltrimethylammonium Chloride Barban PF-02543547-00 Fenoxycarb Metaxalone Racecadotril Maleate Gabexate Mesylate Isethionate Cetraxate HCl Trans-4-(Aminomethyl)-Cyclohexanecarboxylic Acid Aminocaproic Acid Aminolevulinic Acid HCl Vigabatrin Azelaic Acid Undecylenic Acid Chlorobutanol Hexylene Glycol Penicillamine AM-580 Bezafibrate Diatrizoic Acid Diatrizoic Acid Related compound A Iothalamic Acid Iodipamide Ipodate Sodium Chloramphenicol Chloramphenicol Palmitate Iopamidol L-701,252 Flumequine Pazufloxacin L-689,560 Rebamipide PD-0167868-0000 Statil Balsalazide Olsalazine Disodium AG 957 Tranilast PD 098,059 ST638 Colchicine Trimethylcolchicinic Acid HCl Oxytetracycline Novobiocin Levodopa Metyrosine Liothyronine Aminosalicylic Acid Mesalamine m-Aminophenol Levonordefrin HCl Tyrphostin 51 Tyrphostin A9 Tyrphostin AG 879 Capsazepine A-77636 HCl HCl Norapomorphine HBr, R(-)- , hydrochloride 2-Methyl-5-Hydroxytryptamine Maleate BW 723C86 HCl Oxitriptan 6-Chloromelatonin CP-099994-01 Primaquine Phosphate Maleate HCl HCl HCl TetraHCl HCl HCl Fumarate DiH2O UK-538348-40 HCl HCl SC-39566A Capsaicin Dihydrocapsaicin Acetate Rolipram Troxipide Anisomycin Hemifumarate Malonate HCl HCl Fumarate HCl Sulfate CP-114271 BRL 37344 Sodium UK-519218-02 Epinephrine L-Bitartrate HCl Isoproterenol HCl L-Bitartrate HCl Suloctidil Amphotericin B Nystatin Mepartricin A Azithromycin Josamycin Dirithromycin Rapamycin 7,8-Dihydroneopterin Zanamivir Hydrate Amikacin Tobramycin Netilmicin Sulfate Sisomicin Sulfate Streptomycin Sulfate Miglitol Glucosamine HCl Voglibose 1,1-Dimethyl Biguanide HCl Altretamine Auramine O HCl Diphenylthiocarbazone M-Iodobenzylguanidine Hemisulfate Salt 5-(N-Ethyl-N-Isopropyl)- Amiloride HCl Phenamil Methanesulfonate Anilazine Irsogladine Maleate WY-14643 10, 11-Epoxy Carbamazepine 3,4,4'-Trichlorocarbanilide Diflubenzuron Hydroxyurea Ciclopirox Olamine Pirfenidone Fluridon Amrinone Milrinone N-Methyl-Beta-Carboline-3-Carboxamide TJU103 Amlexanox Alloxazine Pteroic Acid Parbendazole Leflunomide NVP-ABE-171 0119307-0015 Siguazodan Zardaverine CP-057915 Carmofur Uracil Mustard Amobarbital Secobarbital 5-Nitro-6,7-Dichloro-1,4-Dihydro-2,3- Flutamide 5,5'-Dithiobis(2-Nitrobenzoic Acid) Ro 41-0960 Nifuroxazide 1,1'-Trimethylenebis[4-(Hydroxyiminomethyl)Pyridinium Pralidoxime Chloride 0151832-0042 NO-711 HCl Furaltadone Etanidazole Secnidazole , 6-Nitro-, Maleate Maleate Salt Diethyl 1,4-Dihydro-2,6-Dimethyl-3,5-Pyridinedicarboxylate Methyl 2-(Phenylthio)Ethyl 1,4-Dihydro-2,4,6-Trimethylpyridine-3,5-Dicarboxylate Desalkylflurazepam 1-(2-Chlorophenyl)-N-Methyl-N-(1-Methylpropyl)-3-Isoquinolinecarboxamide Lormetazepam Temazepam Clofazimine Quazepam Pyridaben 3-Methyl-6-(3-[Trifluoromethyl]Phenyl)-1,2,4-Triazolo-(4,3-B)Pyridazine CGS-15943 ODQ Triazolam Midazolam Fluconazole Flutriafol Voriconazole Dacarbazine Antipyrine Ibudilast Zaleplon Sulfinpyrazone Bitertanol Triadimefon Triadimenol Ebselen Ezetimibe NS-1619 UK-471858 LY 225910 PD-0216948-0000 PD-0185718-0002 Etomidate HCl Clopidogrel Bisulfate Ticlopidine HCl MK-886 Clomethiazole HCl UK-387284-04 Ro 41-1049 HCl Imazalil Sertaconazole Nitrate Cefaclor Cephradine Cefoxitin Cephalothin Sodium Cefdinir Cefixime Cefotaxime Sodium Cefpodoxime Proxetil Ceftriaxone Sodium E-Isomer Ceftazidime Pentahydrate Cefazolin Cefoperazone Dihydrate Cefmetazole Moxalactam Disodium Sodium Amoxicillin Carbenicillin Monosodium Monohydrate Aztreonam E-isomer Mezlocillin Sodium Piperacillin Sodium Sulbactam Methidathion 8-Bromoguanosine 3',5'-Cyclicmonophosphate 8-Chloroadenosine 3',5'-Cyclic-Monophosphate UK-080067 (4-Nitrobenzyl)-6-Thioguanosine, S- 6-Methylmercaptopurine Riboside 6-Mercaptoguanosine 2-Chloro- N6-Cyclopentyladenosine Cladribine N6-Cyclopentyladenosine 5'-N-Ethylcarboxamidoadenosine 2-Phenylaminoadenosine 3-Deazaadenosine Vidarabine N6-Benzyladenosine Puromycin Aminonucleoside Xanthosine Mizoribine Ribavirin Sodium Capecitabine Enocitabine 5-Fluorocytidine 5-Fluorouridine Gemcitabine HCl 5-Bromo-2'-Deoxycytidine Floxuridine 4-Thiouridine Azacytidine Lamivudine Zalcitabine 2',3',5'-Tri-O-Acetyluridine Doxifluridine Tegafur 5-Ethyl-2'-Deoxyuridine Stavudine Zidovudine Related Compound B Zidovudine Abacavir Sulfate Olomoucine Acyclovir Adefovir Dipivoxil Famciclovir CE-308034 Tenofovir Amprolium HCl Pyrithiamine HBr Hydroxychloroquine Sulfate Thiamine Monophosphate Chloride DiH20 Thiochrome CJ-023487-01 PD 123,319 Ditrifluoroacetate Benomyl Ro 15-4513 Apazone 3-Isobutyl-1-Methylxanthine Temozolomide Doxofylline Pentoxifylline Xanthinol Nicotinate Cilostazol Maleate Olmesartan Irbesartan Valsartan HCl PD-0132301-0002 Phosphate Iodide SC-40230 Imatinib Mesylate Citrate PF-03281206-01 Hydrogen Maleate HCl HCl HCl Ergonovine Maleate Methylergonovine Maleate Maleate HBr Eburnamonine, (-)- Vinpocetine LY-53,857 Maleate PF-00224440-00 5-Methoxy-N,N-Dimethyltryptamine HCl Erythro-9-(2-Hydroxy-3-Nonyl)Adenine HCl N6-Cyclopentyl-9-Methyladenine Methanesulfonate DiHCl Mesylate Camptothecin Irinotecan HCl Diaziquone Mitomycin Fropenem Epalrestat EBPC Tetramethrin Thalidomide Enalaprilat Lisinopril Enalapril Maleate Ramipril Protirelin Cycloheximide Finasteride m- Ciglitizone PD-0128042-0000 UK-073967 UK-079300 Stanozolol WIN-51708 Cilazapril Benazepril Quinapril Atorvastatin Calcium Itriglumide Vincristine Sulfate Nelfinavir Saquinavir PD-0134308-0533 PD-0154075-0000 Methotrexate Raltitrexed Octreotide Acetate Thiostrepton Pioglitazone Rosiglitazone Maleate Hydrate HCl Clindamycin Phosphate Cyclosporine IBZM, S(-)- L-Tartrate, S(-)- HCl Mesylate Ergotaminine Dihydroergocristine Methanesulfonate Mesylate Rifabutin Rifampin Rifapentine AG-036170 5-Methyl- Urapidil Ciprofloxacin HCl Gatifloxacin Lomefloxacin HCl Sparfloxacin Fleroxacin Rufloxacin HCl Enoxacin Piromidic Acid L-Tartrate UK-419376-51 HCl HCl HCl CP-093393-01 Praziquantel Related Compound A Praziquantel Related Compound B Praziquantel Related Compound C DiHCl DiHCl Fipexide HCl ICI 204,448 HCl GR 89696 Fumarate Zopiclone Moricizine HCl ICI-199,441 HCl PF-00318418-00 PD-0129290-0002 U-62066 Itraconazole HCl ARC 239 DiHCl BMY 7378 DiHCl SNC 121 WAY 100635 Maleate Dilazep DiHCl DiHCl PF-02314494-00 Metocurine Iodide Tubocurarine Chloride Hydrate HCl RS 23597-190 HCl RS 67333 HCl HCl Mesylate HCl HCl Gefitinib UK-052046-27 Tyrphostin AG 1517 Vesamicol HCl DiHCl Fumarate Hycanthone Mitoxantrone diHCl diHCl HCl Quin 2 PD-0196860-0000 PF-01272315-00 Y-25130 HCl SC-51089 SC-51322 HCl Dihydrocodeine L-Bitartrate Hydrocodone L-Bitartrate Galantamine HBr Codeine Sulfate Morphine Sulfate Pentahydrate Butorphanol L-Tartrate BNTX Maleate Nalmefene Nalbuphine HCl Naltrexone Alcuronium Chloride L-741,626 HCl 3-Tropanyl--3-Carboxylate HCl Benztropine Mesylate 3-Tropanyl-3,5-Dichlorobenzoate Tropine 2-(4-Chlorophenoxy)Butanoate, Maleate HCl HCl Methylbromide Methscopolamine Bromide HBr GYKI 52466 HCl methbromide, 1(S), 9(R), (-)- Chloride Sanguinarine Chloride HCl SKF-96365 HCl BP 554 Maleate UK-076654-42 Mycophenolate Mofetil HCl Cinchonine Sulfate Sulfate Quininone Mesylate Tromethamine HCl Bromide 3-Quinuclidinyl Benzilate Hemicholinium-3 HBr Amiprilose HCl Gallamine Triethiodide Pancuronium Bromide Meperidine HCl PRE-084 HCl HCl Tiamulin Fumarate HBr Levallorphan L-Tartrate Cephaeline HBr Benproperine Phosphate Tartrate HCl L-Tartrate HCl HCl YS 035 HCl Amorolfine HCl Levopropoxyphene Napsylate Succinate HCl HCl hydrochloride Dyclonine HCl Pramoxine HCl Centrophenoxine HCl HCl Halofantrine HCl Hexahydro-Sila-Difenidol HCl, P-Fluoro Analog HCl HCl HCl HCl hydrochloride Clomiphene Citrate Clomiphene Related Compound A CP-166221 Citrate Citrate Mechlorethamine HCl Bromhexine HCl HCl Tosylate Edrophonium Chloride HCl HCl Terbinafine HCl Thiobencarb HCl Levocarnitine Chloride Succinylcholine Chloride HCl HCl Camostat Mesylate PD-0154117-0137 Demecarium Bromide Chlorambucil Pentetic Acid Mebrofenin Sodium Proglumide Eusolex 6007 HCl HCl Proparacaine HCl SDZ-205, 557 HCl Denatonium Benzoate QX-314 HCl N-Acetylprocainamide Succinate CGS-12066A Maleate CP-709877 PAPP Quipazine Dimaleate L-745,870 TriHCl GBR 12783 DiHCl GBR 12909 DiHCl GBR 13069 DiHCl Cis(Z)- DiHCl Propericyazine 1,1-Dimethyl-4-Phenyl-Piperazinium Iodide Diphemanil Methylsulfate Decamethonium Bromide Pentolinium Bi-L-Tartrate Methiodide Maleate Malate Methanesulfonate HCl Bi-l-Tartrate DiH20 PD-0143188-6614 Chlorpheniramine Maleate DiHCl Fumarate Pyrilamine Maleate Imiquimod Maleate Pamoate Quinaldine Red Maleate Trimeprazine Hemi-L-Tartrate Methiothepin Mesylate Maleate Anpirtoline HCl Threo Isomer CP-869342-00 DiHCl DiHCl Fomepizole Sulfate HCl HCl Ethionamide Sulfate Salt Mecamylamine HCl HCl HCl Iminodibenzyl HCl Chloroethylclonidine DiHCl Clobenpropit 2HBr HCl HCl Phosphate Mesylate BU224 HCl HCl HCl N,N'-Bis[3-(4,5-Dihydro-1H-Imidazol-2-Yl)Phenyl]Urea Dipropanoate PF-03253804-00 HCl Trimethaphan Camsylate UK-456872 Thioguanine 1-Butyl-3-Sulfanilylurea Glyburide Amprenavir HCl H-7 diHCl HA-1077 DiHCl ML-9 HCl H-9 DiHCl malate CP-122288-42 Brinzolamide Dorzolamide SB-269970 HCl Delavirdine Mesylate CP-820218 PNU-0101387G RS 67506 HCl SB-271046 hydrochloride Althiazide Benzthiazide Bendroflumethiazide Hydroflumethiazide Methyclothiazide Polythiazide Clopamide Indapamide Folpet Saccharin 2-Hydroxysaclofen Bensulide PD-0166793-0000 4,4'-Diaminostilbene-2,2'-Disulfonic Acid Dapsone Mafenide Acetate Sulfanilamide Sulfabenzamide 2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid Phenolsulfonphthalein Ethoxzolamide Sodium Sulfaphenazole Sulfathiazole Sulfamoxol Sulfisoxazole Torsemide Sulfadiazine Sulfamerazine Sulfamethazine Sulfisomidine Sulfaquinoxaline Sulfadoxine Sulfadimethoxine Sulfamonomethoxine Sulfamethoxypyridazine PD-0180988-0016 Rosuvastatin Ca Lansoprazole Pantoprazole Sodium Rabeprazole

1205 medicines Desoximetasone Betamethasone Fludrocortisone Halometasone monohydrate Fludrocortisone Acetate Flumethasone Pivalate Hydrocortisone Prednisolone Prednisone Meprednisone Beclomethasone Dipropionate Mometasone Furoate Loteprednol etabonate Fluocinonide Halcinonide Acetonide Flurandrenolide 4-Hydroxyestrone 2-Hydroxyestradiol 4-Hydroxyestradiol Estriol 1,3,5(10)-Estratrien-2,3-Diol-17-One 2-Methyl Ether 2-Methoxyestradiol Mestranol 17Beta-Estradiol 17-Hemisuccinate Estradiol Cypionate Equilenin Podocarpic Acid Allopregnanolone Dehydrocholic Acid Ursodiol Terpin Hydrate Alprostadil Dinoprostone Misoprostol Allethrin Triacetin Latanoprost Loxoprofene Quinic Acid Succinic Anhydride Budesonide Digitoxin Mupirocin Mycophenolate Mofetil HCl Simvastatin Pravastatin Artemether Piperonyl Butoxide SC-41930 SC-53228 11-Beta,17-Alpha-Dihydroxypregn-4-Ene-3,20-Dione 17Alpha-Hydroxypregnenolone 4-Androsten-4-Ol-3,17-Dione 17Alpha-Hydroxyprogesterone Medroxyprogesterone Enoxolone Oleanolic Acid Desogestrel Gestrinone Gestodene Norgestrel 5-Cholesten-3Beta-Ol-7-One Calcifediol 19-Hydroxyandrost-4-Ene-3,17-Dione Uvaol 17 Alpha-Dihydroequilin Equilin Norethindrone Norethynodrel Testosterone Tibolone Exemestane Dydrogesterone Progesterone Canrenone Spironolactone Chlormadinone Acetate Ethynodiol Diacetate Melengestrol Acetate Medroxyprogesterone Acetate Megestrol Acetate Desoxycorticosterone Pivalate Hydroxyprogesterone Caproate Testosterone Decanoate All-Trans-Retinol Phytonadione Ubidecarenone Clofibrate Ciprofibrate Bromopropylate Fenofibrate Deltamethrin Cyfluthrin Lambda-Cyhalothrin Fenpropathrin Fenvalerate Chloroxylenol Bis(2-Hydroxy-5-Chlorophenyl) Bithionol Dichlorophen Hexachlorophene Diflunisal Flurbiprofen Bupropion HCl Dicofol Lindane Mitotane Acemetacin Indomethacin Cerivastatin Fluvastatin Montelukast Sodium 1,5-Isoquinolinediol 5,7-Dichlorokynurenic Acid Fenarimol Metyrapone FPL 64176 Bisacodyl Papaverine HCl RG-13022 Ethacrynic Acid Butylparaben Ethylparaben Gemfibrozil Octyl Salicylate Dienestrol Dienestrol Diacetate Phenothrin Enterodiol Monobenzone Nabumetone Citrinin Dehydroacetic Acid Dithianon 1,4-Benzoquinone Menadione Phenindione Benzoyl Peroxide Ketoprofen Mandelic Acid Pyromellitic Acid Ibuprofen Niacin 2-Tert-Butyl-4-Hydroxyanisole 3-tert-Butyl-4-hydroxyanisole Guaiacol Propofol Probucol Oxybenzone Erbstatin Analog Fenoprofen Sodium Methylparaben Naproxen Aspirin Diacerein Triflusal Aloe-Emodin Emodin Butein Isoliquiritigenin Phloretin Resorcinol Salicylic Acid Aurintricarboxylic Acid Salsalate Trisalicylic Acid Amygdalin Trihydrate Arbutin Guaifenesin Aloin Mangiferin Diosmin Rutin Aflatoxin B1 Aflatoxin G1 Etoposide Teniposide Podophyllotoxin Cromolyn Sodium Dicumarol Coumestrol Methoxsalen Gallocatechin Gallate, (-)- Gossypetin Kaempferol Hematein PCO 400 O-Cresolphthalein Phenolphthalein Bromadiolon Warfarin Phenprocoumon Amifostine CGP 35348 Alendronate Sodium Pamidronate Ibandronate sodium Carmustine Deferoxamine Mesylate Ifosfamide Busulphan Acamprosate Calcium Mesna Sodium 0155098-0000 Modafinil Omethoate Coumaphos Chlorpyriphos-Methyl Fenchlorphos Leptophos Profenofos Bromfenvinphos Tetrachlorvinphos Fensulfothion Isomalathion Tetraethyl Pyrophosphate Phorate Arsenic Trioxide Trichlorfon Fosfomycin Tromethamine Risedronate Sodium Clodronic acid disodium salt Tiludronate Disodium DL-Thiorphan Actarit Aminohippuric Acid o-Iodohippuric Acid Aspartame Related Compound A H-Tyr-Tyr-OH Aspartame Epibestatin HCl Nateglinide Acetaminophen Acetanilide Phenacetin Benzocaine Butamben Methyl Anthranilate Mexiletine HCl 4-(N-[3-Chlorophenyl]-Carbamoyloxy)-2-Butynyltrimethylammonium Chloride Barban PF-02543547-00 Felbamate Fenoxycarb Metaxalone Racecadotril Fluvoxamine Maleate Gabexate Mesylate Pentamidine Isethionate Cetraxate HCl Gabapentin Trans-4-(Aminomethyl)-Cyclohexanecarboxylic Acid Aminocaproic Acid Aminolevulinic Acid HCl Vigabatrin Azelaic Acid Undecylenic Acid Chlorobutanol Hexylene Glycol Penicillamine Sorbitol AM-580 Bezafibrate Diatrizoic Acid Diatrizoic Acid Related compound A Iothalamic Acid Aceclofenac Sodium Iodipamide Ipodate Sodium Chloramphenicol Chloramphenicol Palmitate Iohexol Iopamidol Metrizamide Efavirenz L-701,252 Flumequine Pazufloxacin Ochratoxin A L-689,560 Rebamipide PD-0167868-0000 Statil Balsalazide Olsalazine Disodium AG 957 Tranilast PD 098,059 ST638 Colchicine Trimethylcolchicinic Acid Minocycline HCl Oxytetracycline Novobiocin Carbidopa Levodopa Metyrosine Liothyronine Aminosalicylic Acid Mesalamine m-Aminophenol Salicylamide Levonordefrin Pseudoephedrine HCl Tyrphostin 51 Tyrphostin A9 Tyrphostin AG 879 Capsazepine A-77636 HCl Fenoldopam Dihydrexidine HCl Norapomorphine HBr, R(-)- Nebivolol, hydrochloride Paroxetine 2-Methyl-5-Hydroxytryptamine Maleate BW 723C86 HCl Oxitriptan 6-Chloromelatonin Melatonin CP-099994-01 Primaquine Phosphate Tegaserod Maleate Atomoxetine HCl Nisoxetine HCl Fluoxetine HCl Bifemelane Methoctramine TetraHCl Nortriptyline HCl Atenolol Carteolol HCl Formoterol Fumarate DiH2O UK-538348-40 Benserazide HCl Midodrine HCl SC-39566A Capsaicin Dihydrocapsaicin Flecainide Acetate Rolipram Troxipide Anisomycin Carvedilol Isamoltane Hemifumarate Bopindolol Malonate Propranolol HCl Betaxolol HCl Metoprolol Fumarate Levobunolol HCl Nadolol Penbutolol Sulfate CP-114271 BRL 37344 Sodium UK-519218-02 Sulfate Epinephrine L-Bitartrate Phenylephrine HCl Isoproterenol HCl Norepinephrine L-Bitartrate HCl Tulobuterol HCl Suloctidil Deflazacort Docetaxel Paclitaxel Amphotericin B Nystatin Mepartricin A Aclarubicin HCl Azithromycin Clarithromycin Erythromycin Josamycin Dirithromycin Roxithromycin Rapamycin 7,8-Dihydroneopterin Zanamivir Hydrate Amikacin Tobramycin Netilmicin Sulfate Sisomicin Sulfate Streptomycin Sulfate Miglitol Glucosamine HCl Voglibose 1,1-Dimethyl Biguanide HCl Altretamine Auramine O HCl Pinacidil Diphenylthiocarbazone Acetate M-Iodobenzylguanidine Hemisulfate Salt Phenformin HCl 5-(N-Ethyl-N-Isopropyl)-Amiloride Amiloride HCl Phenamil Methanesulfonate Anilazine Irsogladine Maleate Lamotrigine WY-14643 10, 11-Epoxy Carbamazepine Carbamazepine Oxcarbazepine 3,4,4'-Trichlorocarbanilide Diflubenzuron Phenacemide Hydroxyurea Zileuton Ciclopirox Olamine Pirfenidone Fluridon Amrinone Milrinone Niacinamide Pyrazinamide N-Methyl-Beta-Carboline-3-Carboxamide TJU103 Amlexanox Alloxazine Pteroic Acid Albendazole Parbendazole Mebendazole Leflunomide Isradipine NVP-ABE-171 Phenytoin 0119307-0015 Siguazodan Zardaverine CP-057915 Carmofur Uracil Mustard Amobarbital Secobarbital Mephobarbital Primidone 5-Nitro-6,7-Dichloro-1,4-Dihydro-2,3-Quinoxalinedione Flutamide Acenocoumarol 5,5'-Dithiobis(2-Nitrobenzoic Acid) Ro 41-0960 Nifuroxazide Nitrofurazone 1,1'-Trimethylenebis[4-(Hydroxyiminomethyl)Pyridinium Bromide Pralidoxime Chloride 0151832-0042 NO-711 HCl Furaltadone Furazolidone Nitrofurantoin Molsidomine Etanidazole N-Benzyl-2-Nitro-1 H-Imidazole-1-Acetamide Ornidazole Secnidazole Quipazine, 6-Nitro-, Maleate Amlodipine Maleate Salt Diethyl 1,4-Dihydro-2,6-Dimethyl-3,5-Pyridinedicarboxylate Felodipine Lacidipine Methyl 2-(Phenylthio)Ethyl 1,4-Dihydro-2,4,6-Trimethylpyridine-3,5-Dicarboxylate Nifedipine Nitrendipine Flunitrazepam Clonazepam Nitrazepam Desalkylflurazepam Nordazepam 1-(2-Chlorophenyl)-N-Methyl-N-(1-Methylpropyl)-3-Isoquinolinecarboxamide Diazepam Lormetazepam Temazepam Clofazimine Quazepam Pyridaben 3-Methyl-6-(3-[Trifluoromethyl]Phenyl)-1,2,4-Triazolo-(4,3-B)Pyridazine CGS-15943 ODQ Alprazolam Triazolam Midazolam Fluconazole Flutriafol Voriconazole Lonidamine Oxiconazole Nitrate Dacarbazine Antipyrine Ibudilast Anastrozole Zaleplon Oxyphenbutazone Sulfinpyrazone Bitertanol Triadimefon Triadimenol Ebselen Linopirdine Ezetimibe NS-1619 UK-471858 LY 225910 PD-0216948-0000 Nevirapine PD-0185718-0002 Bifonazole Clotrimazole Etomidate Ozagrel HCl Pilocarpine Ondansetron Telmisartan Clopidogrel Bisulfate Ticlopidine HCl MK-886 Clomethiazole HCl UK-387284-04 Ro 41-1049 HCl Imazalil Miconazole Sertaconazole Nitrate Tioconazole Cefaclor Cefprozil Z-Isomer Cephradine Cefoxitin Cephalothin Sodium Cefdinir Cefixime Cefotaxime Sodium Cefpodoxime Proxetil Ceftriaxone Sodium E-Isomer Ceftazidime Pentahydrate Cefazolin Cefoperazone Dihydrate Cefmetazole Moxalactam Disodium Dicloxacillin Sodium Amoxicillin Ampicillin Sodium Carbenicillin Monosodium Monohydrate Hetacillin Cyclacillin Methicillin Sodium Sodium Aztreonam E-isomer Mezlocillin Sodium Piperacillin Sodium Chlormezanone Sulbactam Methidathion 8-Bromoguanosine 3',5'-Cyclicmonophosphate 8-Chloroadenosine 3',5'-Cyclic-Monophosphate UK-080067 (4-Nitrobenzyl)-6-Thioguanosine, S- 6-Methylmercaptopurine Riboside 6-Mercaptoguanosine 2-Chloro- N6-Cyclopentyladenosine Cladribine N6-Cyclopentyladenosine 5'-N-Ethylcarboxamidoadenosine 2-Phenylaminoadenosine 3-Deazaadenosine Vidarabine N6-Benzyladenosine Puromycin Aminonucleoside Xanthosine Mizoribine Ribavirin Citicoline Sodium Capecitabine Enocitabine 5-Fluorocytidine 5-Fluorouridine Gemcitabine HCl 5-Bromo-2'-Deoxycytidine Floxuridine 4-Thiouridine Azacytidine Lamivudine Zalcitabine 2',3',5'-Tri-O-Acetyluridine Doxifluridine Tegafur 5-Ethyl-2'-Deoxyuridine Stavudine Zidovudine Related Compound B Zidovudine Abacavir Sulfate Olomoucine Acyclovir Penciclovir Adefovir Dipivoxil Famciclovir CE-308034 Tenofovir Amprolium HCl Pyrithiamine HBr Hydroxychloroquine Sulfate Thiamine Monophosphate Chloride DiH20 Thiochrome CJ-023487-01 PD 123,319 Ditrifluoroacetate Benomyl Flumazenil Ro 15-4513 Apazone 3-Isobutyl-1-Methylxanthine Temozolomide Doxofylline Dyphylline Pentoxifylline Xanthinol Nicotinate Cilostazol Timolol Maleate Olmesartan Irbesartan Valsartan Cinanserin HCl PD-0132301-0002 Disopyramide Phosphate Isopropamide Iodide SC-40230 Imatinib Mesylate Fentanyl Citrate PF-03281206-01 Citrate Terguride Hydrogen Maleate Bupivacaine HCl Ropivacaine Mepivacaine HCl Ropinirole HCl Ergonovine Maleate Methylergonovine Maleate Methysergide Maleate Citalopram HBr Eburnamonine, (-)- Vinpocetine LY-53,857 Maleate Metergoline PF-00224440-00 5-Methoxy-N,N-Dimethyltryptamine Benzoate Zolmitriptan Granisetron HCl Erythro-9-(2-Hydroxy-3-Nonyl)Adenine HCl N6-Cyclopentyl-9-Methyladenine Pergolide Methanesulfonate Rimcazole DiHCl Tetrindole Mesylate Cyanocobalamin Camptothecin Irinotecan HCl Diaziquone Mitomycin Fropenem Epalrestat EBPC Tetramethrin Thalidomide Methsuximide Paramethadione Captopril Enalaprilat Lisinopril Enalapril Maleate Ramipril Levetiracetam Piracetam Protirelin Oxiracetam Cycloheximide Ethosuximide Finasteride Glutethimide m-Aminoglutethimide Ciglitizone PD-0128042-0000 Orlistat UK-073967 UK-079300 Etodolac Paxilline Stanozolol Mifepristone WIN-51708 Cilazapril Benazepril Quinapril Atorvastatin Calcium Itriglumide Repaglinide Vincristine Sulfate Nelfinavir Saquinavir PD-0134308-0533 PD-0154075-0000 Methotrexate Raltitrexed Octreotide Acetate Thiostrepton Pioglitazone Rosiglitazone Maleate Picotamide Hydrate Tropicamide Clindamycin HCl Clindamycin Phosphate Cyclosporine IBZM, S(-)- Raclopride L-Tartrate, S(-)- Remoxipride HCl Bromocriptine Mesylate Ergotaminine Dihydroergocristine Methanesulfonate Dihydroergotamine Mesylate Dactinomycin Rifabutin Rifampin Rifapentine AG-036170 5-Methyl-Urapidil Urapidil Nifekalant Ciprofloxacin HCl Gatifloxacin Lomefloxacin HCl Sparfloxacin Fleroxacin Rufloxacin HCl Enoxacin Piromidic Acid Droperidol Domperidone Pimozide Oxatomide Ketanserin L-Tartrate UK-419376-51 Azelastine HCl Trazodone HCl Pirenperone Risperidone Ritanserin Buspirone HCl CP-093393-01 Palonosetron Praziquantel Praziquantel Related Compound A Praziquantel Related Compound B Praziquantel Related Compound C Pirenzepine DiHCl Telenzepine DiHCl Fipexide HCl ICI 204,448 HCl Linezolid GR 89696 Fumarate Zopiclone Loratadine Moricizine HCl ICI-199,441 HCl PF-00318418-00 PD-0129290-0002 U-62066 Itraconazole Nefazodone Prochloraz Ketoconazole Terconazole Diltiazem HCl ARC 239 DiHCl BMY 7378 DiHCl SNC 121 WAY 100635 Maleate Dilazep DiHCl lomerizine DiHCl PF-02314494-00 Metocurine Iodide Tubocurarine Chloride Cisapride Hydrate Nemonapride Metoclopramide HCl RS 23597-190 HCl RS 67333 HCl Alfuzosin HCl Doxazosin Mesylate Prazosin HCl Terazosin HCl Gefitinib UK-052046-27 Tyrphostin AG 1517 Vesamicol HCl Minaprine DiHCl Dipyridamole Levodropropizine Quetiapine Fumarate Hycanthone Mitoxantrone diHCl Naftopidil diHCl Ranolazine HCl Quin 2 Lafutidine PD-0196860-0000 PF-01272315-00 Moclobemide Y-25130 HCl SC-51089 SC-51322 Buprenorphine HCl Dihydrocodeine L-Bitartrate Hydrocodone L-Bitartrate Galantamine HBr Codeine Sulfate Morphine Sulfate Pentahydrate Butorphanol L-Tartrate BNTX Maleate Nalmefene Nalbuphine HCl Naltrexone Alcuronium Chloride L-741,626 Roxindole HCl 3-Tropanyl-Indole-3-Carboxylate HCl Benztropine Mesylate 3-Tropanyl-3,5-Dichlorobenzoate Tropine 2-(4-Chlorophenoxy)Butanoate, Maleate Lobeline HCl Ipratropium Bromide Cocaine HCl Homatropine Methylbromide Methscopolamine Bromide Scopolamine HBr Amfonelic Acid Cinoxacin GYKI 52466 HCl Bicuculline methbromide, 1(S), 9(R), (-)- Noscapine Berberine Chloride Sanguinarine Chloride Aniracetam Buflomedil HCl SKF-96365 HCl BP 554 Maleate UK-076654-42 Piperine Raloxifene Mycophenolate Mofetil Tiagabine HCl Cinchonine Sulfate Quinine Sulfate Quininone Dolasetron Mesylate Ketorolac Tromethamine Yohimbine HCl Clidinium Bromide Mepenzolate Bromide 3-Quinuclidinyl Benzilate Trospium chloride Hemicholinium-3 HBr Amiprilose HCl HCl Gallamine Triethiodide Propantheline Bromide Pancuronium Bromide Carbetapentane Citrate Meperidine HCl PRE-084 HCl Oxybutynin HCl Oxyphenonium Bromide Tiamulin Fumarate Dextromethorphan HBr L-Tartrate Levallorphan L-Tartrate Cephaeline HBr Benproperine Phosphate Ifenprodil Tartrate Apomorphine HCl Tolterodine L-Tartrate Donepezil HCl Verapamil HCl YS 035 HCl Amorolfine HCl Levopropoxyphene Napsylate Doxylamine Succinate Citrate Diphenylpyraline HCl Ebastine Eperisone HCl Tolperisone hydrochloride Dyclonine HCl Pramoxine HCl Centrophenoxine Clorgyline HCl Tramadol HCl Venlafaxine HCl Halofantrine HCl Hexahydro-Sila-Difenidol HCl, P-Fluoro Analog Haloperidol Loperamide HCl Fexofenadine HCl Terfenadine Amitriptyline HCl Doxepin HCl Olopatadine hydrochloride Clomiphene Citrate Clomiphene Related Compound A CP-166221 Tamoxifen Citrate Toremifene Citrate Mechlorethamine HCl Bromhexine HCl Sibutramine HCl Bretylium Tosylate Edrophonium Chloride Naftifine Pargyline HCl Selegiline HCl Terbinafine HCl Disulfiram Thiobencarb Chloride Chloride Acetylcarnitine HCl Levocarnitine Methacholine Chloride Succinylcholine Chloride Bambuterol HCl Celiprolol HCl Camostat Mesylate Itopride PD-0154117-0137 Trimebutine Demecarium Bromide Physostigmine Salicylate Pyridostigmine Bromide Chlorambucil Pentetic Acid Mebrofenin Lorglumide Sodium Proglumide Eusolex 6007 Chloroprocaine HCl Procaine HCl Proparacaine HCl SDZ-205, 557 HCl Lidocaine Denatonium Benzoate QX-314 Crotamiton Prilocaine HCl N-Acetylprocainamide Amoxapine Loxapine Succinate CGS-12066A Maleate Clozapine Olanzapine Astemizole CP-709877 Azaperone PAPP Quipazine Dimaleate L-745,870 TriHCl Cinnarizine Cetirizine GBR 12783 DiHCl GBR 12909 DiHCl GBR 13069 DiHCl Cis(Z)-Flupentixol DiHCl Perphenazine Propericyazine 1,1-Dimethyl-4-Phenyl-Piperazinium Iodide Diphemanil Methylsulfate Decamethonium Bromide Pentolinium Bi-L-Tartrate Oxotremorine Methiodide Azatadine Maleate Pizotifen Malate Cyclizine Mirtazapine Metaphit Methanesulfonate Phencyclidine HCl Nicotine Bi-l-Tartrate DiH20 PD-0143188-6614 HCl Chlorprothixene Chlorpheniramine Maleate Maleate Zimelidine DiHCl Methapyrilene Fumarate Pyrilamine Maleate HCl Imiquimod Nomifensine Maleate Pyrvinium Pamoate Quinaldine Red Maleate Acepromazine Maleate Trimeprazine Hemi-L-Tartrate Methiothepin Mesylate Methdilazine Thioridazine Prochlorperazine Maleate Anpirtoline Desloratadine Methylphenidate HCl Threo Isomer Maleate Salt CP-869342-00 Betahistine DiHCl Histamine DiHCl Fomepizole Nialamide Phenelzine Sulfate Procarbazine HCl HCl Iofetamine HCl Ethionamide Amphetamine Sulfate Salt HCl Mecamylamine HCl Memantine HCl Rimantadine HCl Iminodibenzyl Tacrine Ketamine HCl Sertraline Chloroethylclonidine DiHCl Clobenpropit 2HBr Tizanidine HCl Epinastine HCl Antazoline Phosphate Phentolamine Mesylate BU224 HCl HCl HCl Idazoxan HCl Lofexidine HCl N,N'-Bis[3-(4,5-Dihydro-1H-Imidazol-2-Yl)Phenyl]Urea Dipropanoate Cimetidine PF-03253804-00 HCl Nizatidine Levamisole HCl Trimethaphan Camsylate Talipexole UK-456872 Xylazine Riluzole Thiabendazole Thioguanine 1-Butyl-3-Sulfanilylurea Chlorpropamide Glipizide Glimepiride Gliquidone Glyburide Amprenavir Tamsulosin HCl Amisulpride Sulpiride H-7 diHCl HA-1077 DiHCl ML-9 HCl H-9 DiHCl Almotriptan malate CP-122288-42 Sumatriptan Brinzolamide Dorzolamide Probenecid SB-269970 HCl Thiothixene Delavirdine Mesylate Ipsapirone Perospirone Argatroban Vardenafil Citrate CP-820218 PNU-0101387G Zafirlukast RS 67506 HCl SB-271046 hydrochloride Cyclothiazide Althiazide Benzthiazide Bendroflumethiazide Quinethazone Hydrochlorothiazide Hydroflumethiazide Chlorothiazide Trichlormethiazide Metolazone Methyclothiazide Polythiazide Clopamide Indapamide Furosemide Xipamide Folpet Chlorthalidone Saccharin 2-Hydroxysaclofen Bicalutamide Bensulide HCl PD-0166793-0000 4,4'-Diaminostilbene-2,2'-Disulfonic Acid Dapsone Suramine Sodium Salt Mafenide Acetate Sulfanilamide Sulfabenzamide Sulfacetamide 2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid Phenolsulfonphthalein Rofecoxib Ethoxzolamide Parecoxib Sodium Valdecoxib Zonisamide Topiramate Celecoxib Sulfaphenazole Acetazolamide Sulfamethizole Sulfathiazole Sulfamoxol Sulfisoxazole Torsemide Sulfadiazine Sulfamerazine Sulfamethazine Sulfisomidine Sulfapyridine Sulfaquinoxaline Sulfadoxine Sulfadimethoxine Sulfamonomethoxine Sulfamethoxypyridazine Ampiroxicam Meloxicam Piroxicam Tenoxicam PD-0180988-0016 Rosuvastatin Ca Lansoprazole Omeprazole Pantoprazole Sodium Rabeprazole

Supplementary Figure 1b: 88 BioPrint (with accession numbers) Assays

BioPrint Assay Match in 1179 protein dataset(seq. stats, 2nd number is pval, lower is better) Accession # _5HT1A Beta-2 86 2e-16 NM_000524 _5HT2A 5-hydroxytryptamine 2A receptor (5HT2A) 5424 0.0 X57830 _5HT3 endothelial protein C receptor precursor 38 0.076 D49394 _5HT4E 5-hydroxytryptamine 4 receptor (5HT4) 856 0.0 Z48150 _5HT6 5-hydroxytryptamine 6 receptor (5HT6) 3249 0.0 L41147 _5HT7 5-hydroxytryptamine 7 receptor (5HT7) 2968 0.0 U68488 _5HTtrans Sodium-dependent transporter(5HTT) 4119 0.0 X70697 A1 3511 0.0 X68485 A2A 5251 0.0 X68486 A2B 3435 0.0 X68487 A3 3511 0.0 X76981 ACHase Acetylcholinesterase (ACHE) 4397 0.0 M55040 Alpha1 Alpha-1D 733 0.0 L31771 Alpha2A Alpha-2A adrenergic receptor 3015 0.0 M18415 Androgen receptor 2662 0.0 L29496 AT1 Type-1 angiotensin II receptor (AT1) 3770 0.0 Z11162 AT2 Type-2 angiotensin II receptor (AT2) 5467 0.0 U20860 ATPase H,K-ATPase beta subunit 2722 0.0 M75110 B2 B2 (BK2) 2440 0.0 X86164 BB3 3 (BRS-3) 2801 0.0 L08893 Beta1 Beta-1 adrenergic receptor 1707 0.0 J03019 Ca_chan_NTYPE Factor Protein C 40 0.010 AY196208 Ca_channel_DHP , voltage-dependent, L type, alpha 1B subunit (CA... 64 5e-10 AF422930 Ca_channel_dilt calcium channel, voltage-dependent, L type, alpha 1B subunit (CA... 64 5e-10 AF422930 Ca_channel_VERA calcium channel, voltage-dependent, L type, alpha 1B subunit (CA... 64 5e-10 AF422930 CAMKII Calcium/calmodulin-dependent proteinkinase II beta subunit (CAMK... 559 e-158 AB023185 Carb_anhydr carbonic anhydrase II 2018 0.0 X03251 CB1 1 (CB1) 3372 0.0 X54937 CB2 Cannabinoid receptor 2 (CB2) 3519 0.0 X74328 CCKA Cholecystokinin type A receptor (CCKA) 2644 0.0 L19315 CCKB Cholecystokinin type B receptor (CCKB) 3965 0.0 D13305 Cl_channel Casein kinase II alpha chain (CK II) 38 0.11 AY112737 CXCR4 CXCR4 3653 0.0 Y14739 CYP2B6 Cytochrome P450 2B6 3346 0.0 M29874 CYP2C19 Cytochrome P450 2C19 (S-mephenytoin4-hydroxylase) 3461 0.0 M61854 D1 D(1A) receptor 4207 0.0 X55760 D2 D(2) 4859 0.0 S69899 D4_4 D(4) dopamine receptor 1150 0.0 L12398 DA_trans Sodium-dependent (DAT) 7692 0.0 S46955 Delta Delta-type receptor (DOR-1) 1102 0.0 AL009181 ETA Endothelin-1 receptor (ETA) 2258 0.0 S81542 ETB (ETB) 3156 0.0 L06623 GABA_A Gamma-aminobutyric-acid receptor alpha-5subunit (GABA(A)-A5) 107 8e-23 X14766 GABA_A_BZD Gamma-aminobutyric-acid receptor alpha-5subunit (GABA(A)-A5) 107 8e-23 X14766 GABA_trans 4-aminobutyrate aminotransferase (GABAT) 1485 0.0 U29701 Ghrelin Growth secretagogue receptor type1 (GHS-R) 2183 0.0 U60179 (GR) 2444 0.0 S68378 Glycine receptor alpha-1 chain 50 1e-05 AJ310839 Guan_cyc 1, soluble, beta 3 4825 0.0 P16068 HIV solute carrier organic anion transporterfamily, member 1B1 (SLCO... 42 0.020 AF004885 iNOS Neuronal synthase (NOS1) 119 1e-26 AF534821 IR_1 Imidazoline (I-1) receptor candidate 1469 0.0 XM_592945 K_channel_Ca Intermediate conductancecalcium-activated (IK1) 58 9e-08 AF292389 Kainate Kappa Kappa-type (KOR-1) 856 0.0 L36130 LTD4 Cysteinyl receptor (CYSLT1) 1289 0.0 AF119711 M1 Muscarinic receptor M1 4163 0.0 M35128 M2 Muscarinic M2 2589 0.0 AB041391 MAO_a B (MAOB) 170 9e-42 D00688 MC1 Melanocortin-1 receptor (Melanocytestimulating hormone receptor ... 385 e-106 AB177607 MC3 Melanocortin-3 receptor (MC3-R) 2147 0.0 L06155 MC4 Melanocortin-4 receptor (MC4-R) 1980 0.0 L08603 MCH1 Orphan GPCR GPR7 46 3e-04 Z86090 ML1 type 1A (MEL-1A-R) 163 9e-40 NM_205362 Motilin (GPR38) 2775 0.0 AF034632 MT3 MMP-16 (MT-MMP 3) 3699 0.0 D85511 Mu Mu-type opioid receptor (MOR-1) 2920 0.0 U12569 Na_channel Voltage-gated (SCN10A, PN3, Nav1.8) 595 e-169 M27902 nACHR_M Acetylcholine receptor protein, alpha-6chain 46 2e-04 Y00762 nACHR_N Acetylcholine receptor protein, alpha-6chain 46 2e-04 Y00762 NE_trans Sodium-dependent noradrenalinetransporter (NAT) 902 0.0 X91117 NK1 Substance-P receptor (SPR / NK-1 receptor) 2906 0.0 M81797 NMDA Lysosomal carboxypeptidase C (CathepsinA) 38 0.12 AF416558 ORL1 2482 0.0 L40949 PCP Glutamate [NMDA] receptor subunit 2B 5773 0.0 M91562 PDE11A (cGMP/cAMP-specificphosphodiesterase 11A / HSPDE11A) 3537 PDE11 0.0 AJ251509 PDE2A (cGMP-stimulated cGMP/cAMP-specificphosphodiesterase 2A / ... 7525 PDE2 0.0 U67733 PDE5A (cGMP-binding, cGMP-specificphosphodiesterase 5A / HSPDE5A) 5035 PDE5 0.0 AB015656 Rolipram phosphodiesterase 4A, cAMP-specific(phosphodiesterase E2 dunce h... 1106 0.0 BC044786 Sigma Sigma opioid receptor 359 1e-98 AF004218 Sst4 type 4 (SS4R) 2238 0.0 D16826 Sst5 Somatostatin receptor type 5 (SS5R) 1.036e+04 0.0 AL031713 Thy_R Thyroid hormone receptor alpha-1(C-ERBA-alpha-1 / EAR7) 3655 0.0 M24748 Tryptase morphogenetic protein 7 precursor 38 0.034 U35237 V1a Vasopressin V1A receptor 6298 0.0 U19906 V2 Vasopressin V2 receptor 2591 0.0 AF101728 VIP1 Vasoactive intestinal polypeptide receptor1 (VIP-R-1) 4181 0.0 U11087 Y1 receptor type 1 (NPY1-R) 3140 0.0 M88461

Supplementary Figure 1c: 1179 Proteins (Accession Numbers) used for generating the co-investigation frequency spectra.

Target Name Accession 14-3-3gamma protein AB024334 15-hydroxy dehydrogenase J05594 2,3-oxidosqualene-lanosterol cyclase S81221 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase AF273765 3-oxo-5 alpha- 4-dehydrogenase 2 M74047 4-aminobutyrate aminotransferase (GABAT) U80226 4-hydroxyphenylpyruvate dioxygenase X72389 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase BC008879 5-hydroxytryptamine 1A receptor (5HT1A) AB037529 5-hydroxytryptamine 1B receptor (5HT1B) AL049595 5-hydroxytryptamine 1D receptor (5HT1D) M89955 5-hydroxytryptamine 1E receptor (5HT1E) M92826 5-hydroxytryptamine 1F receptor (5HT1F) AB037533 5-hydroxytryptamine 2A receptor (5HT2A) X57830 5-hydroxytryptamine 2B receptor (5HT2B) X77307 5-hydroxytryptamine receptor (5HT2C) M81778 5-hydroxytryptamine 4 receptor (5HT4) Z48150 5-hydroxytryptamine 5A receptor (5HT5A) X81411 5-hydroxytryptamine 6 receptor (5HT6) L41147 5-hydroxytryptamine 7 receptor (5HT7) U68488 5-hydroxytryptamine receptor 3 subunit C(5HT3C) AF459285 5-methyltetrahydrofolate-homocysteinemethyltransferase U75743 5'-methylthioadenosine phosphorylase U22233 5-oxo-ETE receptor (TG1019) BC063549 6-O-methylguanine-DNA methyltransferase(MGMT) X54228 6PF-2-K/FRU-26-P2ase liver-type isozyme(includes 6- phosphofructo-2-kinase) AL049732 6-Phosphofructokinase C ( type) D25328 7-dehydrocholesterol reductase AF110060 a disintegrin and metalloproteinasedomain 17 (tumor necrosis factor, alpha, converting ) U92649 ABL kinase AJ131467 Acetylcholine receptor protein, alpha-6chain U62435 Acetylcholinesterase (ACHE) M55040 Acetyl-CoA carboxylase U19822 acid alpha-glucosidase preproprotein S76893 Acrosin Y00970 activin A receptor, type IB (ACVR1B) L31848 Activin receptor type I (ACTR-I / ALK-2) L02911 Activin receptor type II (ACTR-II) X62381 Activin receptor type IIB (ACTR-IIB) X77533 Activin receptor-like kinase 1 (ALK-1) U77713 Acyl-CoA A: acyltransferase 1(ACAT1) L21934 acyl-CoA synthetase long-chain family member 1 L09229 acyl-CoA synthetase short-chain family member 2 AF263614 ADAM-12 (meltrin alpha) AF023477 ADAMTS-4 (aggrecanase 1) AF148213 adaptor-associated kinase 1 (AAK1) AB028971 Adenine nucleotide translocator 3 (ANT3) J03592 Adenosine A1 receptor X68485 Adenosine A2A receptor X68486 Adenosine A2B receptor X68487 Adenosine A3 receptor X76981 Adenosine deaminase (adenosineaminohydrolase) M13792 Adenosine kinase U50196 adenylate cyclase 5 U65473 Adenylate kinase 1 (AK1) J04809 adiponectin precursor D45371 ADME: Adenylyl cyclase 1 L05500 ADP-ribosylation-like factor 6 interacting protein 5 BC005143 adrenomedullin D43639 Adrenomedullin receptor (Y13583) Y13583 advanced glycosylation end product-specific receptor precursor agouti related protein homolog U89485 aminotransferase U70732 dehydrogenase beta-1-subunit(ADH1-2) L38290 Alcohol dehydrogenase class I gammasubunit (ADH3) X04299 aldo-keto reductase family 1, member A1 J04794 aldo-keto reductase family 1, member C1 M86609 Aldose reductase M59783 alpha 1,4-galactosyltransferase AB041418 Alpha mannosidase II D63998 Alpha platelet-derived growth factorreceptor (PDGF-R- alpha) M22734 Alpha-1A adrenergic receptor D32201 Alpha-1-antitrypsin AF119873 Alpha-1B adrenergic receptor L31773 Alpha-1D adrenergic receptor S70782 alpha-1-fetoprotein transcription factor(LRH1) (NR5A2) AF124247 Alpha-2A adrenergic receptor M18415 Alpha-2B adrenergic receptor M34041 Alpha-2C-1 adrenergic receptor D13538 Alpha2Delta Calcium Channel AF042793 Alpha-2-plasmin inhibitor J02654 Alpha-amylase X07057 Alpha-L-fucosidase X01390 alpha-synuclein L36675 Alpha-tryptase (Tryptase 1) AF098328 Alpha- X06956 amine oxidase, containing 3 precursor AF054985 Aminopeptidase A (Glutamylaminopeptidase) L14721 Aminopeptidase B AL390139 Aminopeptidase N (Microsomalaminopeptidase) AJ421875 AMPKa2 U06454 X13466 Androgen receptor L29496 Angiopoietin 1 receptor (TIE-2) (TEK) L06139 Angiotensin converting enzyme 2 (ACE2) AF241254 Angiotensin-converting enzyme 1 (ACE1) M26658 angiotensinogen preproprotein K02215 Aortic carboxypeptidase-like protein ACLP D86479 Apolipoprotein A AF158663 apolipoprotein B precursor X03325 Apolipoprotein E Z70760 Aquaporin 4 (AQP4) U34845 Arachidonate 12-lipoxygenase S68588 Arachidonate 15-lipoxygenase M23892 Arachidonate 5-lipoxygenase J04520 A-RAF Proto-oncogene /threonineprotein kinase U01337 vasopressin-neurophysin II preproprotein AF031475 Aromatic amino acid decarboxylase (ddc) L05075 ASIC2a Sodium channel(hBNaC2) U78180 Aspartate carbamoyltransferase (CAD) M38561 Aspartylglucosaminidase M64075 ATP citrate lyase X64330 ATP-binding cassette transporter 1(ABCA1) AF165281 ATP-binding cassette, sub-family B(MDR/TAP), member 1 (ABCB1) (Multidrug resistance P-glycoprotein(MDR1) AF016535 ATP-binding cassette, sub-family G(WHITE), member 2 (ABCG2) (Breast cancer resistance protein) AF098951 ATP-sensitive inward rectifier potassiumchannel 1 (KIR 1.1) U12541 Aurora-related kinase 1 (ARK1) AF008551 Aurora-related kinase 2 (ARK2) AF015254 autocrine motility factor receptor M63175 AXL tyrosine protein kinase (UFO, GAS6receptor) X57019 B lymphocyte tyrosine kinase (BLK) S76617 B1 bradykinin receptor (BK1) U12512 B2 bradykinin receptor (BK2) X86164 BACE (beta-secretase) (BACE1) AF200193 baculoviral IAP repeat-containing protein 4 U45880 basigin X64364 BCL1 (Cyclin D1) M64349 BCL2 M14745 BCL2-associated X protein AF008196 BCL2-interacting killer BC001599 BDNF/NT-3 growth factors receptor (TRK-B) S76473 Beta platelet-derived growth factorreceptor (PDGF-R-beta) J03278 Beta-1 adrenergic receptor J03019 Beta-2 adrenergic receptor AF202305 Beta-3 adrenergic receptor X72861 Beta-adrenergic receptor kinase 1 (ARK-1)(GRK2) X61157 Beta-adrenergic receptor kinase 2 (ARK-2)(GRK3) X69117 beta-transducin repeat containing protein AF101784 Beta-tubulin X00734 Bombesin receptor 3 (BRS-3) L08893 bone morphogenetic protein 1 (BMP1) M22488 bone morphogenetic protein 2 preproprotein AL035668 bone morphogenetic protein 7 precursor AL157414 Bone morphogenetic protein-4 type IIreceptor U25110 B-RAF Proto-oncogene (p94 kinase) M21001 branched chain aminotransferase 1, cytosolic U21551 Branched-chain alpha-keto aciddehydrogenase kinase AF026548 breast cancer 2, early onset X95152 Brutons tyrosine kinase (BTK) X58957 Butyrylcholinesterase M16541 C3A anaphylatoxin chemotactic receptor(C3AR) U28488 C5A anaphylatoxin chemotactic receptor(C5AR) X57250 cadherin 16 precursor AF016272 cadherin 3, type 1 preproprotein X63629 Calcineurin B subunit isoform 1 (Proteinphosphatase 2B regulatory subunit) M30773 calcitonin preproprotein Calcitonin gene-related peptide type 1receptor U17473 (CT-R) L00587 calcitonin-related polypeptide, beta X04855 calcium channel, voltage-dependent, alpha 1I subunit (CACNA1I) (Cav3.3) AF211189 calcium channel, voltage-dependent, L type, alpha 1B subunit (CACNA1B) (Cav2.2) M94173 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A) (Cav2.1) U79663 Calcium/calmodulin-dependent proteinkinase II beta subunit (CAMK-II beta subunit) AF140350 Calcium-activated potassium channel Slo(MaxiK subunit) U11058 Calmodulin M19311 Calpain 1 X04366 Calpain 2 M23254 Cannabinoid receptor 1 (CB1) X54937 Cannabinoid receptor 2 (CB2) X74328 Carbonic anhydrase I M33987 carbonic anhydrase II X03251 carbonic anhydrase IV precursor L10955 carbonic anhydrase IX precursor X66839 carbonic anhydrase XII precursor carbonyl reductase 1 BC002511 carbonyl reductase 3 BC002812 Carboxypeptidase B2 (TAFI) AL137141 Carcinoembryonic antigen CEA X16454 carcinoembryonic antigen-related cell adhesion molecule 5 M17303 Carnitine O-acetyltransferase (fragment) X78706 Carnitine palmitoyltransferase II M58581 Carnitine/acylcarnitine translocase(CACT) Y10319 Casein kinase I delta (CKI-delta) U29171 Casein kinase I epsilon (CKI-epsilon) AL020993 Casein kinase II alpha chain (CK II) AL049761 Casein kinase II alpha prime chain (CKII) M55268 Caspase 1 (interleukin-1 beta convertase) U13697 Caspase 3 (apopain) U13737 Caspase 7 (ICE-like apoptotic protease 3) U67206 Caspase 8 AF102146 Caspase 9 (ICE-like apoptotic protease 6) AB019205 catalase AY028632 Catechol O-methyltransferase (COMT) Z26491 Cathepsin B (APP secretase) Y18460 Cathepsin D M11233 Cathepsin E AJ250716 Cathepsin G M16117 Cathepsin K U13665 Cathepsin L Y18462 Cathepsin S U07374 caveolin 1 Z18951 caveolin 2 and b caveolin 3 AF036365 CCR1 chemokine receptor L10918 CCR10 chemokine receptor U13667 CCR11 chemokine receptor AF110640 CCR2 chemokine receptor U80924 CCR3 chemokine receptor AF026535 CCR4 chemokine receptor X85740 CCR5 chemokine receptor AF011537 CCR6 chemokine receptor U68030 CCR7 chemokine receptor L31581 CCR8 chemokine receptor Y08456 CD14 antigen precursor X13334 CD164 antigen, sialomucin D14043 CD19 antigen M28170 CD1D antigen, d polypeptide M14664 CD2 antigen (p50), sheep receptor M16336 CD22 antigen AB013007 CD25 Interleukin-2 Alpha (IL2) receptor M14098 CD28 antigen AF222341 CD33 antigen (gp67) M23197 CD34 antigen BC039146 CD36 antigen L06850 CD37 antigen X14046 CD38 antigen D84276 CD4 antigen (p55) S79267 CD40 antigen precursor CD40 D31797 CD44 antigen precursor CD52 antigen X67699 CD59 antigen p18-20 X16447 CD6 antigen X60992 CD72 antigen M54992 CD74 antigen K01144 CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) BC042665 CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) AL022396 CD86 antigen U04343 CDC7-related kinase AB003698 CDK2-associated dual specificity proteinphosphatase L25876 cell division cycle 2-like 2 (CDC2L2) AF067515 C-FOS AF111167 chaperonin M34664 Checkpoint kinase (CHK2) AF086904 Checkpoint kinase CHK1 AF016582 Chemokine CCL2 (MCP1/MCAF) S71513 Chemokine CCL26 (Eotaxin3/IMAC) AF096296 Chemokine CX3C (fractalkine/neurotactin) AC004382 Chemokine CXCL1 (GROa/MGSAa) Chemokine CXCL12 (SDF-1) U16752 Chemokine CXCL8 (IL8) Z11686 , calcium activated,family member 1 AF039400 cholecystokinin preproprotein L00354 Cholecystokinin type A receptor (CCKA) L19315 Cholecystokinin type B receptor (CCKB) D13305 Cholesterol esterase M54994 Cholesteryl ester transfer protein M83573 O-acetyltransferase S56138 Choline/ethanolaminephosphotransferase(CEPT1) AF138862 Chymase (Mast cell protease I) S61334 ciliary neurotrophic factor S72921 Class I alcohol dehydrogenase (ADH1)alpha subunit M12271 class II alcohol dehydrogenase 4 pi subunit M15943 class IV alcohol dehydrogenase 7 mu or sigma subunit X76342 C-MAF (short form) AF055376 Coagulation factor II (Prothrombin) M33031 coagulation factor III precursor M16553 Coagulation factor IX (Christmas factor) K02053 Coagulation Factor Protein C AB083690 Coagulation factor VII (Eptacog alfa) M13232 coagulation factor VIII isoform bprecursor K01740 Coagulation factor X (Stuart factor) M57285 Coagulation factor XI (Plasmathromboplastin antecedent) AB004057 Coagulation factor XII (Hageman factor) L43615 Cold and Receptor (CMR1) BC001135 colony stimulating factor 1 precursor colony stimulating factor 2 precursor M11220 colony stimulating factor 2 receptor,alpha, low-affinity (granulocyte-macrophage) L29349 colony stimulating factor 3 precursor Complement C1R component X04701 Complement C2 (C3/C5 convertase) X04481 complement component 3 precursor K02765 complement component 5 S79279 Complement factor I (C3B/C4B inactivator) J02770 connective tissue growth factor X78947 Corticotropin releasing factor receptor 1(CRF1) U16273 Corticotropin releasing factor receptor 2(CRF2) AC004976 corticotropin releasing hormone binding protein X58022 cRAF kinase X03484 C-reactive protein, pentraxin-related X56692 Creatine kinase M chain M14780 CRTH2 (GPR44) AF144308 CSK tyrosine kinase X60114 Cu/Zn superoxide dismutase (SOD,cytoplasmic) L46374 cubilin AF243082 CX3CR1 receptor U28934 CXCR1 chemokine receptor L19592 CXCR2 chemokine receptor M73969 CXCR3 chemokine receptor U32674 CXCR4 chemokine receptor Y14739 CXCR5 [ receptor for CXCL13 (BLCC/BCA-1)] X68149 Cyclin-dependent kinase 1 (CDK1) X05360 Cyclin-dependent kinase 2 (CDK2) X62071 Cyclin-dependent kinase 3 (CDK3) X66357 Cyclin-dependent kinase 4 (CDK4) U79269 Cyclin-dependent kinase 5 (CDK5) X66364 Cyclin-dependent kinase 8 (CDK8) X85753 cyclin-dependent kinase inhibitor 1B AF213700 Cyclooxygenase 1 (prostaglandinendoperoxide synthase 1) S36219 Cyclooxygenase 2 (prostaglandinendoperoxide synthase 2) M90100 Cysteinyl (CYSLT1) AF119711 Cysteinyl Leukotriene receptor (CysLT2) AB038269 Cystic fibrosis transmembrane conductanceregulator (CFTR) AC000061 deaminase AF095644 Cytochrome P450 11B1 (CYPXIB1) (steroid11-beta- hydroxylase) M24667 Cytochrome P450 11B2 (CYPXIB2) (steroid18-hydroxylase/ synthase) S77409 Cytochrome P450 19 (CYPXIX / aromatase /oestrogen synthetase) Y07508 Cytochrome P450 1A2 (P-3-450) Cytochrome P450 21 (steroid21-hydroxylase) X58899 Cytochrome P450 27B (25-hydroxyvitaminD-1-alpha- AB005038 hydroxylase) Cytochrome P450 2B6 M29874 Cytochrome P450 2C19 (S-mephenytoin4-hydroxylase) M61854 Cytochrome P450 2C9 (CYP2C9) M21939 Cytochrome P450 2D6 (debrisoquine4-hydroxylase) M24499 Cytochrome P450 2E1 (-inducible) J02843 Cytochrome P450 2F1 J02906 Cytochrome P450 3A4 J04449 Cytochrome P450 3A5 (niphedipine oxidase) J04813 Cytochrome P450 51 (lanosterol14-alpha-demethylase) U51692 Cytochrome P450 5A1 (thromboxanesynthase) BC041157 Cytochrome P450 8A1 (prostacyclinsynthase) D84124 cytochrome P450, family 2, subfamily J,polypeptide 2 AF144566 Cytosolic phospholipase A2 AL049797 D(1A) dopamine receptor X55760 D(1B) dopamine receptor M67439 D(2) dopamine receptor S69899 D(3) dopamine receptor U32499 D(4) dopamine receptor L12398 decay accelerating factor for complement (CD55, Cromer blood group system) S72858 Delta-type opioid receptor (DOR-1) AL009181 Deoxycytidine kinase (DCK) M60527 deoxyhypusine synthase U26266 diablo precursor Diacylglycerol kinase alpha (DAG kinasealpha) AF064771 Diacylglycerol O-acyltransferase (DGAT) AF059202 Dihydrofolic acid reductase (DHFR) V00507 Dihydroorotate dehydrogenase M94065 Dihydropyridine-sensitive L-type calciumchannel alpha- 2/delta subunits AF083854 Dihydropyrimidine dehydrogenase AB003063 Dipeptidyl peptidase IV (DPP IV, CD26) X60708 dipeptidylpeptidase 7 AF154502 Dipeptidyl-peptidase I U79415 diphosphomevalonate decarboxylase U49260 disrupted in 1 AJ506177 DNAse I (DRNI) AC005203 Dopamine beta hydroxylase Y00096 Dual specificity protein phosphatase (MAPkinase phosphatase-5 / MKP-5) AF179212 Dual specificity protein phosphatase 3(VHR) L05147 Dual specificity protein phosphatase 8(HVH-5) U27193 Dual specificity protein phosphatase 9(MAP kinase phosphatase-4/ MKP-4) U87167 Dual-specificitytyrosine-(Y)-phosphotylation regulated kinase (DYRK) AB015282 Dual-specificitytyrosine-(Y)-phosphotylation regulated kinase 2 (DYRK2) Y13493 dystrophin Dp140bc isoform M63072 E Selectin (Endothelial leukocyteadhesion molecule 1 / ELAM-1) M24736 E2F-1 (pRB-binding protein) X79444 ectonucleoside triphosphate diphosphohydrolase 1 U87967 ectonucleotide pyrophosphatase/phosphodiesterase 1 AJ242020 egl nine homolog 1 AF229245 empty spiracles homolog 1 X68879 endoglin precursor X72012 Endothelial lipase AF118767 Endothelial nitric oxide synthase (eNOS) D26607 endothelial protein C receptor precursor AL356652 endothelin 1 Z98050 Endothelin B receptor (ETB) L06623 Endothelin-1 receptor (ETA) S81542 Endothelin-converting enzyme 1 (ECE-1) X91923 eomesodermin AJ010280 Ephrin type-A receptor 2 (ECK) M59371 Ephrin type-B receptor 4 (HTK) U07695 epidermal growth factor (beta-urogastrone) X04571 Epidermal growth factor receptor X00663 Epithelial discoidin domain receptor 1(CAK) U48705 epoxide hydrolase 1, microsomal (xenobiotic) BC003567 epoxide hydrolase 2, cytoplasmic AF233336 ERBB-2 receptor protein tyrosine kinase(Tyrosine kinase- type HER2) M11767 ERBB-3 receptor protein tyrosine kinase(Tyrosine kinase- type cell surface receptor HER3) S61953 ERBB-4 receptor protein tyrosine kinase(Tyrosine kinase- type cell surface receptor HER4) L07868 ERK1 Z11696 erythropoietin precursor AF202311 Erythropoietin receptor M34986 receptor alpha (ER-alpha) AL049821 beta (ER-beta) AF074599 eukaryotic translation initiation factor2-alpha kinase 2 (EIF2AK2) M85294 Extracellular calcium-sensing receptor(CASR) S83176 Farnesol receptor HRR-1 U68233 Farnesyl pyrophosphate FPP synthetase J05262 Farnesyl-protein transferase beta-subunit L10414 Fas-activated serine/threonine kinase(FAST) X86779 fatty acid amide hydrolase AF098019 fatty acid binding protein 4, adipocyte BC003672 fatty acid desaturase 2 AF108658 fatty acid synthase U26644 F-box and WD-40 domain protein 1B AB014596 Fc fragment of IgE, low affinity II, receptor for (CD23A) X04772 Fc fragment of IgG, high affinity Ia, receptor (CD64) S45709 Fc fragment of IgG, low affinity IIIa, receptor for (CD16) AB025256 FGFR1 FGF receptor 1 X52833 fibrinogen-like 2 AF104015 Fibroblast activation protein (Seprase) U76833 fibroblast growth factor 10 precursor AB002097 fibroblast growth factor 16 AB009391 fibroblast growth factor 18 precursor AF211188 fibroblast growth factor 2 M17599 fibroblast growth factor 20 AB044277 fibroblast growth factor 21 precursor AB021975 fibroblast growth factor 3 precursor X14445 fibroblast growth factor 4 precursor J02986 fibroblast growth factor 5 precursor fibroblast growth factor 8 precursor fibroblast growth factor 9 precursor AL139378 Fibroblast growth factor receptor 2(FGFR-2) (Keratinocyte growth factor receptor) M97193 fibroblast growth factor receptor 3 precursor fibronectin 1 preproprotein Five-lipoxygenase activating protein(FLAP) X52195 FKBP (12 FK-506) X55741 FKBP-rapamycin associated protein (FRAP,mTOR) L35478 FL cytokine receptor (FLT3) L36162 FMLP-related receptor I (FMLP-RI) D10922 FMLP-related receptor II (FMLP-R-II). M76673 Focal adhesion kinase 1 (FADK 1) L13616 Focal adhesion kinase 2 (FADK 2) S80542 Foetal liver kinase 1 (FLK-1)(geneseqp) Follicle stimulating hormone receptor(FSH-R) S59900 folylpolyglutamate synthase precursor fragile X mental retardation 1 BC038998 FRAP-related protein (FRP1) U49844 frequenin homolog X84048 10 transmembrane receptor AB027464 Frizzled-like receptor homolog(SMO) AF130867 fructosamine 3 kinase AJ404615 Fructose 1,6-bisphosphatase U21931 fumarylacetoacetate hydrolase (fumarylacetoacetase) X51728 G protein-coupled receptor GPR6. U18549 G protein-coupled receptor HM74 (putativeniacin receptor) D10923 G protein-coupled receptor kinase 4(GRK4) L03718 G protein-coupled receptor kinase 5(GRK5) L15388 GABA-B1A receptor AL031983 GABA-B2 receptor AF074483 galactosidase, alpha BC002689 galactosidase, beta 1 M22590 Galanin precursor L11144 type 1 (GAL1) L34339 Galanin receptor type 2 (GAL2) AF042782 galectin-3 S59012 Gamma-aminobutyric-acid receptor alpha-4subunit (GABA(A)-A4) U30461 Gamma-aminobutyric-acid receptor alpha-5subunit (GABA(A)-A5) L08485 Gamma-aminobutyric-acid receptor alpha-6subunit (GABA(A)-A6) S81944 Gamma-aminobutyric-acid receptor gamma-2subunit (GABA(A)-C2) X15376 Gamma-glutamyl carboxylase (hGC) AF253530 Gamma-glutamyl hydrolase AF147083 gastrin preproprotein X00183 Gastrin-releasing peptide receptor(GRP-preferring bombesin receptor) M73481 GATA binding protein 3 X55122 GATA binding protein 4 L34357 glucagon preproprotein J04040 (GL-R) L20316 Glucagon-like peptide 1 receptor (GLP-1R) L23503 Glucagon-like peptide-2 receptor (GLP2R) AF105367 glucocerebrosidase precursor BC003356 Glucocorticoid receptor (GR) S68378 glucose phosphate isomerase BC004982 Glucose transporter type 1(erythrocyte/brain) AF070544 Glucose transporter type 4 (skeletalmuscle - insulin- responsive) M91463 Glucose transporter type 5 (smallintestine) (Fructose transporter) M55531 Glucose-6-phosphatase U01120 glucuronidase, beta M10618 Glutamate [NMDA] receptor subunit 2A U90277 Glutamate [NMDA] receptor subunit 2B U90278 Glutamate [NMDA] receptor subunit 2D U77783 Glutamate [NMDA] receptor subunit epsilon3 L76224 Glutamate [NMDA] receptor subunit zeta 1 L13267 1 (brain, 67kDa)(GAD1) M70434 1 X67491 1 (GLUR-1) M81886 Glutamate receptor 2 (GLUR-2) L20814 Glutamate receptor 5 (GLUR-5 / ionotropickainate 1) L19058 :fructose-6-phosphateamidotransferase (GFAT) M90516 reductase AF228704 Glutathione S-transferase pi (GSTP1) X08094 glycerol-3-phosphate dehydrogenase 1 (soluble) L34041 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) U40367 Glycinamide ribonucleotide transformylase(GARS-AIRS- GART) AF008655 Glycine receptor alpha-1 chain X52009 Glycogen synthase kinase-3 alpha (GSK-3alpha) L40027 Glycogen synthase kinase-3 beta (GSK-3beta) L33801 Glycogenin 1 (GYG) AF065481 Glycogenin 2 (GYG2) U94362 glyoxalase I BC001741 -releasing hormone 1 M12578 Gonadotropin-releasing hormone receptor(GNRH-R) Z99995 G-protein coupled receptor 41 (GPR41) AF024688 G-protein-coupled receptor BONZO (STRL33,CXCR6). U73529 Granzyme B (T-cell serine protease 1-3E) M17016 Group IID secretory phospholipase A2(PLA2) AF188625 growth arrest-specific 6 BC038984 growth differentiation factor 8 AF104922 growth factor receptor-bound protein 2 X62852 growth hormone 1 J03071 Growth hormone receptor M28466 growth hormone releasing hormone preproprotein X00094 Growth hormone secretagogue receptor type1 (GHS-R) U60179 Growth hormone-releasing hormone receptor(GHRH receptor) L01406 GTP cyclohydrolase 1 U66095 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) M63904 guanylate cyclase 1, soluble, alpha 2 X63282 guanylate cyclase 1, soluble, beta 2 AF038499 guanylate cyclase 1, soluble, beta 3 X66533 H,K-ATPase beta subunit M75110 Haematopoietic prostaglandin D synthase AB008830 Heart inducible nitric oxide synthase(NOS2D) AF051164 heme oxygenase (decyclizing) 2 BC002396 heparanase AF084467 Hepatic nuclear factor 4 alpha (HNF4A) AF509467 Hepatic triglyceride lipase J03540 Hepatocyte growth factor receptor (METProto-oncogene tyrosine kinase) U19348 Hepatocyte nuclear factor 4-alpha(HNF-4-alpha) AL132772 HERG Potassium Channel AB009071 Hexokinase 4 (HK4 / Glucokinase) M69051 Hexokinase 5 (HK5) AK026414 hexose-6-phosphate dehydrogenase precursor Z98044 High affinity nerve growth factorreceptor (TRK-A) X03541 High-affinity choline transporter CHT1(SLC5A7) AJ401466 AF026261 D49783 (JAR4) AF140538 (JAR3) (PFI-13) AB044934 Histamine N-methyltransferase (HNMT) AB041388 decarboxylase X54297 histone deacetylase 5 AK027734 HMG-CoA-synthase U29895 Homo sapiens partial CD95 gene for CD95 antigen, exon 8, cell line RF DI1 (2704). AJ509178 hormone-sensitive lipase U40002 Human urate transporter, URAT1 AC044790 hyaluronan synthase 1 U59269 hyaluronan-mediated motility receptor U29343 hydroxyacyl glutathione hydrolase BC000840 hydroxyacyl-Coenzyme A dehydrogenase, type II BC000372 hydroxysteroid (11-beta) dehydrogenase 2 U26726 Hyperpolarization-activated cationchannel HCN4 AJ132429 hypoxia-inducible factor 1, alpha subunit AF207601 Ig superfamily CTLA-4 U90273 IgE Heavy chain Constant region L00022 IkB kinase alpha subunit (IKK alpha) U22512 IkB kinase beta subunit (IKK BETA) AF029684 Ileal sodium-dependent bile acidtransporter Z54350 Imidazoline (I-1) receptor candidate AB023192 IMP (inosine monphosphate) dehydrogenasetype 1 J05272 IMP (pyrophosphatephosphoribosyltransferase) M31642 indoleamine-pyrrole 2,3 dioxygenase X17668 Inducible IkappaB kinase IKK-i D63485 Inducible nitric oxide synthase (NOS2A) S75615 Insulin receptor M10051 insulin receptor substrate 4 AF007567 Insulin-degrading enzyme(Insulysin/Insulinase) M21188 insulin-like growth factor 1 (somatomedin C) M37484 insulin-like growth factor 2 X06161 Insulin-like growth factor bindingprotein 5 protease (HTRA) AF157623 Insulin-like growth factor I receptor X04434 Integrin alpha-1 (laminin and collagenreceptor / VLA-1 / CD49A) Integrin alpha-4 (VLA-4 / CD49D) X16983 Integrin alpha-5 (Fibronectin receptoralpha subunit / VLA-5 / CD49E) X06256 Integrin alpha-7 X74295 Integrin alpha-L (Leukocyte adhesionglycoprotein LFA-1) (CD11A) Y00796 Integrin alpha-M (Leukocyte adhesionreceptor MO1/MAC- 1/CR3) S52227 Integrin alpha-V (Vitronectin receptoralpha subunit / CD51) AF251841 Integrin beta-1 (Fibronectin receptorbeta subunit) (CD29) (VLA-4 beta) X07979 Integrin beta-2 (Cell surface adhesionglycoproteins LFA- 1/CR3/P150,95 beta subunit) (CD18) X64072 Integrin beta-3 (Platelet membraneglycoprotein IIIA / CD61) J02703 Integrin beta-4 (GP150 / CD104) X53587 Integrin-linked kinase (ILK) AJ277481 intercellular adhesion molecule 1 precursor X06990 interferon gamma receptor 1 U19247 interferon, alpha 2 S64994 interferon, beta 1, fibroblast M28622 interferon, omega 1 X58822 interferon-gamma receptor beta chain precursor U05875 interleukin 1 receptor accessory protein AF016261 interleukin 1 AF043143 interleukin 1 receptor, type I precursor X16896 interleukin 1, alpha proprotein CR457414 interleukin 11 precursor AY207429 interleukin 15 precursor interleukin 17 receptor precursor U58917 interleukin 18 receptor 1 precursor U43672 interleukin 2 precursor U25676 Interleukin 2 receptor beta chain (p70-75) AL022314 interleukin 20 precursor AF224266 interleukin 21 AF254069 interleukin 3 receptor, alpha precursor D49410 interleukin 5 receptor, alpha precursor interleukin 6 (interferon, beta 2) Y00081 interleukin 6 receptor precursor interleukin 7 precursor M29053 Interleukin-1 receptor-associated kinase(IRAK) L76191 Interleukin-1 receptor-associated kinase4 (IRAK-4) AF155118 Interleukin-4 (IL-4-R) receptor X52425 Intermediate conductancecalcium-activated potassium channel (IK1) AF022150 intestinal fatty acid binding protein 2 M18079 islet amyloid polypeptide precursor X14905 Isoleucyl-tRNA synthetase U04953 ITK/TSK tyrosine kinase S65186 JAR1A (Orphan GPCR - Putativeneurotransmitter receptor) AF021818 JAR5B (Orphan GPCR GPR52) AL022171 JAR6 (Orphan GPCR PFI-7) AY288416 Kappa-type opioid receptor (KOR-1) L36130 Kell blood group glycoprotein S80081 Kinase deficient protein KDP (WNK1) AL049793 kinesin family member 11 X85137 kininogen 1 M11437 KiSS Receptor AY253982 KIT ligand precursor k-Ras L00048 3-hydroxylase AF056032 lactase- hydrolase preproprotein X07994 lactate dehydrogenase A BC000749 lactate dehydrogenase B BC002362 lactate dehydrogenase C M24515 lactoperoxidase U39573 laminin alpha 3 subunit L34155 leptin receptor U43168 Leucine aminopeptidase AF061738 leukemia inhibitory factor receptor precursor X61615 Leukocyte common antigen related protein(LAR) Y00815 Leukocyte elastase (Neutrophil elastase) M34379 Leukotriene A4 hydrolase J02959 receptor (P2Y purinoceptor7, P2Y7) U33448 2 (BLT2) AB029892 synthase U09353 L-iditol-2 dehydrogenase U67243 LIM domain kinase 1 (LIMK-1) D26309 Lipoprotein Lipase (LPL, Lipase ClearingFactor) M76722 Lipoprotein-associated coagulationinhibitor AF021834 -sensitive myo-inositolmonophosphatase A1 (IMPA1) Y11360 Liver glycogen phosphorylase Y15233 L-kynurenine/alpha-aminoadipateaminotransferase AF097994 Low density lipoprotein receptor AF217403 low density lipoprotein receptor-related protein 5 AF064548 low density lipoprotein-related protein 1 Y18524 L-selectin X16070 luteinizing hormone beta subunit precursor X00264 lymphotoxin alpha precursor AB088112 acyltransferasebeta (LPAAT-B) AF011374 Lysosomal carboxypeptidase C (CathepsinA) AL008726 Lysosphingolipid receptor EDG-1 AF022137 Lysosphingolipid receptor EDG-3 X83864 lysyl oxidase preproprotein S78694 Macrophage colony stimulating factor Ireceptor (CSF-1R) U63963 Macrophage migration inhibitory factor(MIF) L19686 MAD, mothers against decapentaplegic homolog 3 U76622 major histocompatibility complex, class II, DR beta 1 precursor X99896 Maltase glucoamylase AF016833 Mannose-6-phosphate isomerase AF227218 mannosidase, alpha, class 1A, member 1 X74837 MAP kinase activated protein kinase 2(MAPKAPK-2) U12779 MAP kinase activated protein kinase 3(MAPKAPK-3) U09578 MAP kinase activated protein kinase 5(MAPKAPK-5) AF032437 Mast/stem cell growth factor receptor(C-KIT) X06182 matrix, extracellular phosphoglycoprotein with ASARM motif (bone) AJ276396 MaxiK channel beta 2 subunit AF099137 MaxiK channel beta subunit U42601 MEK1 L05624 MEK2 BC000471 Melanin-concentrating hormone receptor 2(MCH2) AB060151 Melanocortin-1 receptor (Melanocytestimulating hormone X65634 receptor MSH-R) Melanocortin-2 receptor(Adrenocorticotropic hormone receptor ACTH-R) X65633 Melanocortin-3 receptor (MC3-R) L06155 Melanocortin-4 receptor (MC4-R) L08603 Melanocortin-5 receptor (MC5-R) L27080 melanoma cell adhesion molecule AF089868 Melatonin receptor type 1A (MEL-1A-R) U14108 Melatonin receptor type 1B (MEL-1B-R) U25341 Membrane-associated kinase (MYT1) AF014118 membrane-spanning 4-domains, subfamily A, member 1 X07203 meningioma expressed antigen 5 (hyaluronidase) BC039583 Metabotropic glutamate receptor 1 U31216 Metabotropic glutamate receptor 2 L35318 Metabotropic glutamate receptor 3 AC002081 Metabotropic glutamate receptor 4 U92457 Metabotropic glutamate receptor 5 D28538 Metabotropic glutamate receptor 6 U82083 Metabotropic glutamate receptor 7 U92458 Metabotropic glutamate receptor 8 AJ236922 Methionine aminopeptidase 2 U13261 Microsomal glutathione S-transferase 3(MGST3) AF026977 Microsomal triglyceride transfer protein X59657 microtubule-associated protein 1A U14577 microtubule-associated protein tau M25298 Mineralocorticoid receptor (MR) M16801 Misshapen/NIK-related kinase MINK AB035698 Mitochondrial 3-ketoacyl-CoA thiolasebeta-subunit of trifunctional protein (LC 3-KAT) D16481 mitochondrial aldehyde dehydrogenase 2 precursor X05409 Mitochondrial uncoupling protein 3 (UCP3) U82818 Mitochondrial uncoupling protein 4 (UCP4) AF110532 Mitochondrial uncoupling protein 5 (UCP5)(Brain mitochondrial carrier protein-1 BMCP1) AF155811 Mitogen and stress-activated proteinkinase-1 (MSK1) AF080000 Mitogen-activated protein kinase 1 (MAPK1/ ERK2) Z11695 Mitogen-activated protein kinase 10(MAPK10 / JNK3) U34820 Mitogen-activated protein kinase 11(MAPK11 / P38 beta) Y14440 Mitogen-activated protein kinase 12(MAPK12 / ERK6 / P38 gamma) U66243 Mitogen-activated protein kinase 13(MAPK13 / P38 delta) AF100546 Mitogen-activated protein kinase 14(MAPK14 / P38-alpha) L35264 Mitogen-activated protein kinase 8 (MAPK8/ JNK1) U35005 Mitogen-activated protein kinase 9 (MAPK9/ JNK2) U34821 Mitogen-activated protein kinase kinase 3(MAP2K3) U66839 Mitogen-activated protein kinase kinase 4(MAP2K4) L36870 Mitogen-activated protein kinase kinase 6(MAP2K6) U39657 Mitogen-activated protein kinase kinase 7(MAP2K7) AF013589 Mitogen-activated protein kinase kinasekinase 1 (MAP3K1 / MEKK1) AF042838 Mitogen-activated protein kinase kinasekinase 11 (MAP3K11 / Mixed lineage kinase 3) U07747 Mitogen-activated protein kinase kinasekinase 3 (MAP3K3 / MEKK3) U78876 Mitogen-activated protein kinase kinasekinase 7 (MAP3K7) (TAK1) AL121964 Mitogen-activated protein kinase kinasekinase 8 (MAP3K8 / COT) D14497 Mitogen-activated protein kinase kinasekinase kinase 4 (MAP4K4 / HGK) AL137755 MMP-1 (collagenase 1) X54925 MMP-10 (stromelysin 2) X07820 MMP-11 (stromelysin 3) X57766 MMP-12 (metalloelastase) U78045 MMP-13 (collagenase 3) X81640 MMP-14 (MT-MMP 1) X90925 MMP-15 (MT-MMP 2) D86331 MMP-16 (MT-MMP 3) D85511 MMP-2 (gelatinase A) M55593 MMP-26 (endometase) AF230354 MMP-3 (stromelysin 1) X05232 MMP-7 (matrilysin) Z11887 MMP-8 (collagenase 2) J05556 MMP-9 (gelatinase B) J05070 (MAOA) S72704 (MAOB) M69177 Monocarboxylate transporter 4 MCT4 U59185 monoglyceride lipase U67963 Motilin Receptor (GPR38) AF034632 M-phase inducer phosphatase 1 (cdc25a) M81933 M-phase inducer phosphatase 2 (cdc25b) Z68092 M-phase inducer phosphatase 3 (cdc25c) M34065 MUC1 mucin precursor Mucosal addressin cell adhesionmolecule-1 (MAdCam) AC005775 Multidrug resistance P-glycoprotein 2/3(MDR2/3) M23234 Multidrug resistance protein 2 (MRP2)(MOAT) (ABCC2) AJ132244 Multidrug resistance-associated protein 1(MRP1) (ABCC1) AF022853 Muscarinic acetylcholine receptor M1 M35128 Muscarinic acetylcholine receptor M2 AB041391 Muscarinic acetylcholine receptor M3 AB041395 Muscarinic acetylcholine receptor M4 X15265 Muscarinic acetylcholine receptor M5 AF026263 Muscle glycogen phosphorylase M32598 muscle specific ring finger protein 1 AJ291713 Mu-type opioid receptor (MOR-1) U12569 Myeloperoxidase X15377 Myosin light chain kinase AF096773 Na,K-ATPase subunit alpha 1 (Cardiacglycoside target) J03007 Na/K-ATPase beta subunit M25160 Na+/glucose cotransporter 1 (SGLT1) Z74021 NAALADase II protein AJ012370 NADPH Cytochrome P450 reductase AF258341 natriuretic peptide precursor A K02043 natriuretic peptide precursor B AB037521 NDR protein kinase Z35102 Nerve growth factor receptor M14764 neural cell adhesion molecule 1 U63041 neuregulin 1 -alpha U02330 neurogranin BC002835 Neuromedin K receptor (NKR / NK-3receptor) M89473 NMU1R (aka FM3) AF044601 Neuromedin-B receptor (NMB-R) M73482 Neuronal nitric oxide synthase (NOS1) L02881 neuropeptide Y AC004485 type 1 (NPY1-R) M88461 Neuropeptide Y receptor type 2 (NPY2-R) U50146 Neuropeptide Y receptor type 5 (NPY5-R) U94320 type 1 (NTR1) X70070 Neurotensin receptor type 2 (NTR2) Y10148 neurotensin/neuromedin N preproprotein U91618 Neutral A(alanine/serine/cysteine/threonine transporter ASCT1) L19444 Neutral endopeptidase (NEP / Neprilysin) Y00811 Neutral sphingomyelinase AF069740 Nicotinic acetylcholine receptor proteinalpha-7 U62436 Nicotinic acetylcholine receptor proteinbeta-2 U62437 N-myristoyltransferase 1 (NMT1) AF020500 Nociceptin receptor L40949 noggin precursor U31202 Non-receptor tyrosine-protein kinase TYK2 X54637 NPC1 (Niemann-Pick disease, type C1, gene)-like 1 AF192523 NPFF2 receptor (NPGPR) AF119815 NT-3 growth factor receptor (TRKC) S76475 Nuclear hormone receptor NOR-1(-derived 1) D85242 Nuclear receptor LXR-alpha U22662 Nuclear receptor NURR1 (Immediate-earlyresponse protein NOT) X75918 Nuclear receptor ROR-alpha-1 U04899 Nuclear receptor ROR-gamma (nuclearreceptor RZR- gamma) U16997 Nucleoside diphosphate kinase A (NDK A)(NM23-H1) X73066 odc1 - ornithine decarboxylase M16650 Oestrogen sulfotransferase (EST-1) Y11195 O-linked GlcNAc transferase AL050366 oncostatin M precursor AC004264 type 1 (OX1R / Hypocretinreceptor type 1) AF041243 Orexin receptor type 2 (OX2R / Hypocretinreceptor type 2) AF041245 Orphan GPCR GPR35 AF027957 Orphan GPCR GPR55 AF096786 Orphan GPCR GPR7 U22491 Orphan nuclear receptor HMR (Earlyresponse protein NAK1) D85245 Orphan transporter XT3 AF075260 OX40 receptor S76792 Oxidative-stress responsive 1 AB029024 oxidised low density lipoprotein (lectin-like) receptor 1 AB010710 Oxysterols receptor LXR-beta U07132 (OT-R) X64878 Oxytocinase U62768 P Selectin (GMP140/granule membraneprotein-140) M60234 p160ROCK protein kinase (ROCK1) U43195 P2X purinoceptor 1 (P2X1) AF020498 P2X purinoceptor 3 (P2X3) Y07683 P2X purinoceptor 7 (P2X7) Y12851 P2Y purinoceptor 1 (P2Y1) AF018284 P2Y purinoceptor 11 (P2Y11) AF030335 P2Y purinoceptor 6 (P2Y6) U52464 platelet ADP receptor AF313449 p53 cellular tumor antigen AF209148 p53-associated gene (MDM2ubiquitin-protein ligase E3) AJ517838 PAK-alpha kinase (PAK-1) PAK-gamma kinase (PAK-2) U25975 Pancreatic chymotrypsin (caldecrin) Y13697 Pancreatic triacylglycerol lipase L24529 parathyroid hormone preproprotein J00301 Parathyroid hormone receptor (PTH2receptor) U47129 Parathyroid hormone-related peptidereceptor (PTHR receptor) U17418 PCP-2 Protein tyrosine phosphatase U71075 PDE10A (cAMP-specific phosphodiesterase10A / HSPDE10A) AL117345 PDE11A (cGMP/cAMP-specificphosphodiesterase 11A / HSPDE11A) AJ251509 PDE2A (cGMP-stimulated cGMP/cAMP- specificphosphodiesterase 2A / HSPDE2A) U67733 PDE3A (cGMP-inhibited cAMPphosphodiesterase 3A / HSPDE3A) M91667 PDE3B (cGMP-inhibited cAMPphosphodiesterase 3B / HSPDE3B) X95520 PDE4B (cAMP-specific phosphodiesterase 4B/ HSPDE4B) M97515 PDE4D (cAMP-specific phosphodiesterase 4D/ HSPDE4D) U50157 PDE5A (cGMP-binding, cGMP-specificphosphodiesterase 5A / HSPDE5A) AB015656 PDE6A (cGMP-specific phosphodiesteraserod alpha subunit 6A / HSPDE6A) AF022380 PDE6B (cGMP-specific phosphodiesteraserod beta subunit 6B / HSPDE6B) X62692 PDE6C (cGMP-specific phosphodiesterasecone 6C / HSPDE6C) X94354 PDE7A (cAMP-specific phosphodiesterase7A / HSPDE7A) L12052 PDE7B (cAMP-specific phosphodiesterase 7B/ HSPDE7B) AJ251860 PDE8A (cAMP-specific phosphodiesterase8A / HSPDE8A) AL109778 PDE8B (cAMP-specific phosphodiesterase 8B/ HSPDE8B) AF079529 PDE9A (cGMP-specific phosphodiesterase 9A/ HSPDE9A) AP001747 PDK1 (3-phosphoinositide-dependentprotein kinase-1) AC005591 Pepsin (pepsinogen A) M26032 peptidyl arginine deiminase, type IV AB017919 peptidylprolyl isomerase D D63861 Peripheral receptor (HPBS) L21954 Peroxisome proliferator activatedreceptor alpha (PPAR- alpha) L02932 Peroxisome proliferator activatedreceptor beta (PPAR- beta/delta) AL022721 Peroxisome proliferator activatedreceptor gamma (PPAR- gamma) U79012 hydroxylase U49897 N-methylase (PNMT) J03280 :ceramide cholinephosphotransferase 1 AB154421 Phosphatidylcholine-hydrolyzingphospholipase D2 AF038441 Phosphatidylinositol 3-kinase catalyticsubunit alpha (PI3 kinase alpha) Z29090 Phosphatidylinositol 3-kinase catalyticsubunit gamma (PI3 kinase gamma) X83368 Phosphatidylinositol 3-kinase homolog(-telangiectasia mutated gene / ATM) Y08455 Phosphatidylinositol-glycan-specificphospholipase D2 AL031230 phosphodiesterase 1A, calmodulin-dependent isoform 2 U40370 phosphodiesterase 1B, calmodulin-dependent U86078 phosphodiesterase 1C, calmodulin-dependent 70kDa U40372 phosphodiesterase 4A, cAMP-specific(phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A) U68532 phosphodiesterase 4C, cAMP-specific(phosphodiesterase E1 dunce homolog, Drosophila) (PDE4C) AC068499 Phosphoenolpyruvate carboxykinase -Cytosolic (PEPCK) L05144 Phosphoenolpyruvate carboxykinase -Mitochondrial (PEPCK) Y11484 Phosphoglycerate kinase 1 V00572 Phosphoinositide-3-kinase, class 2, betapolypeptide (PIK3C2B) Y11312 phospholamban M60411 Phospholipase A2 AC003982 phospholipid transfer protein precursor Phosphorylase B kinase beta regulatorychain X84908 Phosphoserine aminotransferase (PSA) AF113132 Pituitary adenylate cyclase activatingpolypeptide type i receptor (PACAP-R-1) D17516 Plasma kallikrein M13143 Plasminogen M74220 Plasminogen activator inhibitor-1 (PAI-1) X04729 plasminogen activator, urokinase receptor precursor Platelet activating factor receptor(PAF-R) D10202 platelet factor 4 variant 1 M26167 platelet/endothelial cell adhesion molecule (CD31 antigen) AF281290 platelet-derived growth factor beta , preproprotein X02744 pleiotrophin S60110 PLK1 kinase U78073 Poly(ADP-ribose) polymerase (PARP) X56140 polyamine oxidase AK025938 polymerase (DNA directed), beta D29013 potassium channel, subfamily K, member 3 (KCNK3) (TASK-1) AF110524 potassium channel, subfamily K, member 4 (KCNK4) (TRAAK) AF247042 potassium channel, subfamily K, member 5 (KCNK5) (TASK-2) AF084830 potassium channel, subfamily K, member 9 (KCNK9) (TASK-3) AF279809 PP1-alpha Serine/threonine proteinphosphatase M63960 PP1-beta Serine/threonine proteinphosphatase AF092905 PP1-gamma Serine/threonine proteinphosphatase AB030255 Prenylcysteine carboxyl methyltransferase(PCCMT) AF064084 Presenilin 1 (PS-1) AF109907 Presenilin 2 (PS-2) U50871 Presynaptic protein SAP97 U13896 prion protein preproprotein AF085477 proenkephalin V00509 Progastricsin (Pepsinogen C) M18667 Progesterone receptor (PR) AF016381 proliferating cell nuclear antigen J04718 Prolyl endopeptidase AB020018 pro-melanin-concentrating hormone M57703 proopiomelanocortin preproprotein M38297 receptor ( IPreceptor) D38128 receptor (prostanoid DPreceptor) U31332 Prostaglandin E synthase AF010316 receptor EP1 subtype(Prostanoid EP1 receptor) L22647 Prostaglandin E2 receptor EP2 subtype(Prostanoid EP2 receptor) AF134202 Prostaglandin E2 receptor EP3 subtype(Prostanoid EP3 receptor) D86097 Prostaglandin E2 receptor EP4 subtype(Prostanoid EP4 receptor) X97873 Prostaglandin F2-alpha receptor(Prostanoid FP receptor) AB041713 prostaglandin H2 D-isomerase M98538 Prostate specific antigen (PSA) M26663 Prostate-specific membrane antigen (PSM) AF254357 protease, serine, 23 AF193611 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 BC002899 Protein kinase A alpha X07767 Protein kinase C alpha type (PKC-alpha) Protein kinase C beta-I type(PKC-beta-1) X07109 Protein kinase C delta type (NPKC-delta) Protein kinase C epsilon type(NPKC-epsilon) X65293 Protein kinase C eta type (NPKC-eta)(PKC-L) Protein kinase C gamma type (PKC-gamma) Protein kinase C theta type (NPKC-theta) Protein kinase C zeta type (NPKC-zeta) Protein kinase C-like 1 D26181 Protein tyrosine phosphatase 1B M31724 Protein tyrosine phosphatase alpha X54890 Protein tyrosine phosphatase delta S78086 Protein tyrosine phosphatase epsilon X54134 Protein tyrosine phosphatase eta (DEP-1)(CD148) U10886 Protein tyrosine phosphatase zeta U88967 Proteinase activated receptor 2 (PAR-2) Z49993 prothymosin, alpha (gene sequence 28) AF348514 Proton-gated cation channel subunit(ASIC3) AF057711 Proto-oncogene FES tyrosine kinase X06292 Proto-oncogene FYN tyrosine kinase S74774 Proto-oncogene kinase PIM-1 M24779 Proto-oncogene LCK tyrosine kinase U07236 Proto-oncogene tyrosine-protein kinasereceptor RET AJ243297 Proto-oncogene tyrosine-protein kinaseYES M15990 Purine nucleoside phosphorylase (PNP) M13953 Puromycin-sensitive aminopeptidase (PSA) Y07701 Putative chemokine receptor FKSG80 (GPR81) BC066883 pyruvate carboxylase precursor U30891 Pyruvate dehydrogenase kinase 1 (PDK1) L42450 Pyruvate dehydrogenase kinase 2 (PDK2) L42451 Pyruvate dehydrogenase kinase 3 (PDK3) L42452 Pyruvate dehydrogenase kinase 4 (PDK4) AC002451 RAC-alpha serine/threonine kinase(Protein kinase B) X61037 RAC-beta serine/threonine kinase (AKT2kinase) M95936 RAR gamma AJ250835 ras homolog gene family, member A M83094 Receptor protein-tyrosine kinase TKT(TYRO 10) X74764 reelin U79716 regulator of G-protein signaling 4 BC000737 regulator of G-protein signalling 2, 24kDa L13463 relaxin 1 preproprotein X00949 Renin (Angiotensinogenase) X00063 Retinoic acid receptor alpha (RAR-alpha) M73779 Retinoic acid receptor beta-2(RAR-beta-2) M57445 Retinoic acid receptor RXR-alpha X52773 Retinoic acid receptor RXR-beta X63522 Retinoic acid receptor RXR-gamma AL160058 Ribonuclease A (RNase A) S79281 Ribosomal protein S6 kinase M60724 Ribosomal protein S6 kinase II alpha 1 L07597 Ribosomal protein S6 kinase II alpha 3 U08316 RIP2 kinase (RICK) AF078530 runt-related transcription factor 2 AF001450 Ryanodine receptor 1 M91455 Ryanodine receptor 3 AJ001515 S-adenosylhomocysteine hydrolase (AHCY) M61832 S-adenosylmethionine decarboxylase M21154 SAK protein kinase Y13115 sapiens solute carrier family 7 (cationicamino acid transporter, y+ system), member 5 (SLC7A5) AB018542 scavenger receptor class B, member 1 Z22555 sclerostin precursor AF326736 secretin preproprotein AF244355 (SCT-R) U28281 selectin P ligand U02297 selenoprotein S AF328864 serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 X00237 serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 U57450 Serine protease OMI AF141307 Serine/threonine kinase Akt-3 (Proteinkinase B gamma) AJ245709 Serine/threonine protein kinase MARK AF154845 Serine/threonine protein kinase P78 U64205 Serine/threonine protein kinase PAK4 AJ011855 Serine/threonine protein kinase PIM-2 D84454 Serine/threonine protein kinase PRK U56998 Serine/threonine protein phosphatase 2Balpha (Calcineurin A alpha) L14778 serpin peptidase inhibitor, clade A, member 3 precursor M18906 Serum glucocorticoid-regulated kinase 1(SGK) (SGK1) AJ000512 Serum-inducible kinase (SNK) U85755 -binding globulin X16349 SH2-containing inositol polyphosphate5-phosphatase 2 (SHIP-2) L24444 sialophorin J04536 Sigma opioid receptor AF226604 signal transducer and activator of transcription 3 AF029311 signal transducer and activator of transcription 6 U66574 signaling lymphocytic activation molecule family member 1 AL121985 similar to Apolipoprotein A-I precursor (Apo-AI) M11791 single-minded homolog 2 long isoform U80457 Site 1 Protease (S1P) AL133583 Sodium and chloride-dependent GABAtransporter 1 (GAT1) X54673 Sodium and chloride-dependent GABAtransporter 2 (GAT2) U76343 Sodium and chloride-dependent GABAtransporter 3 (GAT3) S75989 Sodium and chloride-dependent glycinetransporter 1 (GLYT1) S70612 Sodium and chloride-dependentbetaine/GABA transporter (BGT1) L42300 Sodium channel protein I alpha subunit (NaV1.1) X65362 Sodium/glucose co-transporter 2 (SGLT2) M95549 Sodium/hydrogen exchanger isoform 1(NHE1) AF141357 Sodium/hydrogen exchanger isoform 2(NHE2) S83549 Sodium-dependent dopamine transporter(DAT) S46955 Sodium-dependent glutamate/aspartatetransporter 1 (EAAT1) D26443 Sodium-dependent noradrenalinetransporter (NAT) X91117 Sodium-dependent transporter S80071 Sodium-dependent (5HTT) X70697 Soluble guanylate cyclase alpha 1 (sGCalpha 1) U58855 solute carrier family 2 (facilitatedglucose transporter), member 10; sugar transporter GLUT10 AL031055 solute carrier family 22 (organic cationtransporter), member 2 (SLC22A2) X98333 solute carrier family 22 (organic cationtransporter), member 4 (SLC22A4) AB007448 solute carrier family 22 (organic cationtransporter), member 5 (SLC22A5) AF057164 solute carrier organic anion transporterfamily, member 1B1 (SLCO1B1) AJ132573 solute carrier organic anion transporterfamily, member 1B3 (SLCO1B3) AJ400763 somatostatin preproprotein J00306 Somatostatin receptor type 1 (SS1R) M81829 Somatostatin receptor type 2 (SS2R) AF184174 Somatostatin receptor type 3 (SS3R) Z82188 Somatostatin receptor type 4 (SS4R) D16826 Somatostatin receptor type 5 (SS5R) AL031713 synthase (SRM) (Putrescineaminopropyltransferase) M34338 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) AJ222801 Sphingosine kinase SPHK1 AF266756 Squalene epoxidase (ERG1) AF098865 Squalene synthetase (ERG9) S76822 SRC Kinase X02647 SREBP cleavage-activating protein D83782 stearoyl-CoA desaturase AB032261 Steroid 17-alpha-hydroxylase M63871 Steroid 5-alpha-reductase AF113128 Steroid hormone receptor ERR1(Estrogen-related receptor alpha) X51416 Steroid hormone receptor ERR2(Estrogen-related receptor beta) X51417 Steroid sulfatase (STS) J04964 Steroidogenic factor 1 (STF-1) D88155 sterol carrier protein 2 precursor sterol regulatory element binding transcription factor 1 U00968 sterol regulatory element-binding transcription factor 2 AL021453 Substance-K receptor (SKR / NK-2 receptor) M57414 Substance-P receptor (SPR / NK-1 receptor) M81797 Subtilisin-like protease PACE4 D28514 Succinate receptor AF348078 sucrase-isomaltase (alpha-glucosidase) M22616 Sulfotransferase 1C2 (SULT1C2) AF186263 SYK tyrosine kinase L28824 Synaptic vesicle protein 2A (SV2A)(KIAA0736) AB018279 syndecan 1 precursor BC008765 tachykinin 1 precursor T-cell cyclophilin (cyclophilin A) X52851 T-cell protein tyrosine phosphatase M25393 Telomerase reverse transcriptase (hTRT) AB016767 Testisin (TEST1) AB031331 TGF-beta receptor type I (TGFR-1 /Activin receptor-like kinase 5 / ALK-5) AF035670 TGF-beta receptor type II (TGFR-2) D28131 -sensitive Na-Cl cotransporter U44128 S76625 thrombomodulin precursor AL049651 thrombopoietin precursor Thrombopoietin receptor M90102 A2 receptor (TXA2-R)(prostanoid TP receptor) D38081 Thy-1 cell surface antigen AF261093 Thymidine phosphorylase (platelet-derivedendothelial cell growth factor) U62317 Thymidylate synthase D00596 Thyroid hormone receptor alpha-1(C-ERBA-alpha-1 / EAR7) M24748 thyroid peroxidase M55702 Thyroid receptor beta M26747 (TSH-R) AC007262 thyrotropin-releasing hormone M63582 Thyrotropin-releasing hormone degradingectoenzyme (TRHDE) AF126372 Thyrotropin-releasing hormone receptor(TRH-R) X75071 tissue inhibitor of metalloproteinase 4 precursor U76456 Tissue plasminogen activator (TPA) L00153 Tissue Transglutaminase (Transglutaminase2/TGM2) M98478 TNF receptor-associated factor 2 U12597 TNF-R (tumor necrosis factor receptortype 1) M60275 toll-like receptor 2 U88878 toll-like receptor 4 U88880 toll-like receptor 7 AF240467 toll-like receptor 9 precursor Tolloid-like protein (TLL) AF282732 Topoisomerase I AL035652 Topoisomerase II AF285158 transcription factor SOX9 Z46629 transferrin AF118063 transforming growth factor, alpha AF123243 transforming growth factor, beta 1 X02812 transforming growth factor, beta 2 M87843 transforming growth factor, beta 3 AY208161 transient receptor potential cationchannel, subfamily V, member 1 (TRPV1) AJ277028 transient receptor potential cationchannel, subfamily V, member 2 (TRPV2) AF129112 transient receptor potential cationchannel, subfamily V, member 4 AX026851 tripartite motif protein TRIM5 AF220025 Tripeptidyl peptidase II (TPP II) M73047 troponin C, slow X07897 troponin T type 2, cardiac L40162 TRP-like channel MTR1 (MTR5) AJ270996 2,3-dioxygenase U32989 1 AF057280 tumor necrosis factor (ligand) superfamily, member 10 U57059 tumor necrosis factor ligand superfamily, member 11 AF019047 tumor necrosis factor receptor superfamily, member 8 precursor tumor-associated calcium signal transducer 1 precursor M32306 Tumour necrosis factor (TNF-alpha) AB088112 TXK tyrosine kinase L27071 Type I 5-prime iodothyronine deiodinase AL031427 Type-1 angiotensin II receptor (AT1) Z11162 Type-2 angiotensin II receptor (AT2) U20860 Tyrosinase J03581 Tyrosine aminotransferase (TAT) X55675 M23597 Tyrosine-protein kinase ACK L13738 Tyrosine-protein kinase HCK (Haemopoieticcell kinase) AL049539 Tyrosine-protein kinase JAK1 (JANUSKINASE 1) M64174 Tyrosine-protein kinase JAK2 (JANUSKINASE 2) AF058925 Tyrosine-protein kinase JAK3 (JANUSKINASE 3) U09607 Tyrosine-protein kinase LYN M79321 Tyrosine-protein kinase receptor TYRO3(RSE) (SKY) X72886 Tyrosine-protein kinase RYK X96588 UDP-Gal:betaGlcNAc beta1,4-galactosyltransferase 2 (B4GALT2) AB024434 UDP-glucose ceramide glucosyltransferase(UGCG) D50840 UDP-glucuronosyltransferase 2 B28(UGT2B28) AF177272 uridine monophosphate synthase BC000364 Uridine nucleotide receptor (UNR) U40223 uridine phosphorylase 1 BC001405 Urokinase-type plasminogen activator(UPA) K02286 Urotensin II receptor (GPR14) AF140631 Vascular cell adhesion protein 1 (VCAM1) M30257 vascular endothelial growth factor precursor vascular endothelial growth factor C preproprotein X94216 Vascular endothelial growth factorreceptor 1 (VEGFR-1 / FLT1) X51602 Vascular endothelial growth factorreceptor 2 (VEGFR-2 / FLK1) L04947 Vascular endothelial growth factorreceptor 3 (VEGFR-3 / FLT4) X68203 vasoactive intestinal peptide preproprotein Vasoactive intestinal polypeptide receptor1 (VIP-R-1) U11087 Vasoactive intestinal polypeptide receptor2 (VIP-R-2) X95097 Vasopressin V1A receptor U19906 Vasopressin V1b receptor L37112 Vasopressin V2 receptor AF101728 vav 1 oncogene X83931 Vesicular acetylcholine transporter U10554 Vesicular VMAT2 L23205 Vitamin D3 receptor (VDR /1,25-dihydroxyvitamin D3 receptor) M65208 v-jun avian sarcoma virus 17 oncogene homolog J04111 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 X13294 Voltage-gated potassium channel KV1.1 L02750 Voltage-gated potassium channel KV1.5 M60451 Voltage-gated sodium channel (SCN10A, PN3, Nav1.8) AF117907 Voltage-gated sodium channel subtype II (NaV1.2) M94055 von Willebrand factor precursor M25865 WEE1-like protein kinase U10564 White homolog (ABCG1) AP001746 dehydrogenase/oxidase U06117 X-prolyl aminopeptidase (aminopeptidaseP) 2, membrane- bound AL023653 ZAP-70 tyrosine kinase AB083211

Supplementary Figure 1d: 1082 COSTART Terms

ABDOMINAL PAIN ABNORMAL DREAMS ABNORMAL EJACULATION ABNORMAL ELECTROENCEPHALOGRAM ABNORMAL GAIT ABNORMAL LABOR ABNORMAL ABNORMAL STOOLS ABNORMAL VISION ABSCESS ACCIDENTAL FALL ACCIDENTAL INJURY ACCIDENTAL OVERDOSE ACHLORHYDRIA ACID PHOSPHATASE INCREASED ACIDOSIS ACNE ACRODYNIA ACUTE BRAIN SYNDROME ACUTE ACUTE LEUKEMIA ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MONOBLASTIC LEUKEMIA ACUTE MYELOBLASTIC LEUKEMIA ADAMS STOKES SYNDROME ADDICTION ADDISONIAN CRISIS ADENOMA ADRENAL CORTEX ATROPHY ADRENAL CORTEX HYPERPLASIA ADRENAL CORTEX NECROSIS ADRENAL DISORDER ADRENAL HEMORRHAGE AGITATION AGRANULOCYTOSIS AIDS AKATHISIA AKINESIA ALBUMINURIA ALCOHOL INTOLERANCE ALDOSTERONE INCREASED ALKALINE PHOSPHATASE INCREASED ALKALOSIS ALLERGIC MYOCARDITIS ALLERGIC REACTION ALOPECIA AMBLYOPIA AMENORRHEA AMYLASE INCREASED AMYLOIDOSIS ANAPHYLACTOID REACTION ANEMIA ANGINA PECTORIS ANGIOEDEMA ANISOCORIA ANOREXIA NERVOSA ANORGASMIA SYNDROME ANTISOCIAL REACTION ANURIA AORTIC STENOSIS APATHY APHASIA APHTHOUS STOMATITIS APLASTIC ANEMIA APNEA APPLICATION SITE REACTION ARACHNOIDITIS ARTERIAL ANOMALY ARTERIAL ARTERIOSCLEROSIS ARTERIOSPASM ARTERITIS ARTHRALGIA ARTHRITIS ARTHROSIS ASCITES ASPHYXIA ASPIRATION ASTHENIA ASTHMA ATAXIA ATELECTASIS ATRIAL ARRHYTHMIA ATRIAL FIBRILLATION ATRIAL FLUTTER ATRIAL SEPTAL DEFECT ATROPHIC RHINITIS AV BLOCK AV BLOCK COMPLETE AV BLOCK SECOND DEGREE AVITAMINOSIS B12 DEFICIENCY ANEMIA BACK PAIN BACTERIAL RESISTANCE BALANITIS INTOXICATION BASOPHILIA BEING QUERIED BEZOAR BIGEMINY BILIARY ATRESIA BILIARY PAIN BILIRUBINEMIA BILIRUBINURIA BIPOLAR AFFECTIVE DISORDER - DEPRESSIVE BIPOLAR AFFECTIVE DISORDER - MANIC BLADDER CALCULUS BLADDER CARCINOMA BLADDER NEOPLASM BLADDER PAIN BLEEDING TIME DECREASED BLEEDING TIME INCREASED BLEPHARITIS BLINDNESS BLOOD DYSCRASIA BLOODY BODY ODOR BONE DISORDER BONE NECROSIS BONE NEOPLASM BONE PAIN BONE SARCOMA BRADYCARDIA BRAIN ABSCESS BRAIN BRAIN STEM DISORDER BREAST ABSCESS BREAST ATROPHY BREAST CARCINOMA BREAST ENGORGEMENT BREAST ENLARGEMENT BREAST NEOPLASM BREAST PAIN BRONCHIECTASIS BRONCHIOLITIS BRONCHITIS BRONCHOSTENOSIS BRUISE BUN INCREASED BUNDLE BRANCH BLOCK BURSITIS CACHEXIA CALCIUM DISORDER CARCINOMA CARCINOMA OF LARYNX CARCINOMA OF LUNG CARCINOMA OF MOUTH CARDIOMEGALY CARDIOMYOPATHY CARDIOSPASM CARDIOVASCULAR DISORDER CAROTID OCCLUSION CAROTID THROMBOSIS CARPAL TUNNEL SYNDROME CATATONIC REACTION CELLULITIS CEREBELLAR ATAXIA CEREBELLAR SYNDROME CEREBRAL ARTERIAL THROMBOSIS CEREBRAL EMBOLISM CEREBRAL HEMORRHAGE CEREBRAL INFARCT CEREBRAL CEREBRAL THROMBOSIS CEREBRAL VENOUS THROMBOSIS CEREBROVASCULAR ACCIDENT CEREBROVASCULAR DISORDER CERVICAL POLYP CERVICITIS CERVIX CARCINOMA CHEILITIS CHEST PAIN CHILLS CHILLS AND CHLOASMA CHOLANGITIS CHOLECYSTITIS CHOLELITHIASIS CHOLESTATIC JAUNDICE SYNDROME DECREASED CHOLINESTERASE INCREASED CHONDRODYSTROPHY CHOREOATHETOSIS CHORIORETINITIS CHOROIDITIS CHROMATOPSIA CHROMOSOME ABNORMALITY CHRONIC BRAIN SYNDROME CHRONIC LEUKEMIA CHRONIC LYMPHOCYTIC LEUKEMIA CHRONIC MONOCYTIC LEUKEMIA CHRONIC MYELOCYTIC LEUKEMIA CIRCULATION DISORDER CIRCUMORAL CIRRHOSIS OF LIVER CLEFT LIP CLEFT PALATE CLUBFOOT CNS DEPRESSION CNS NEOPLASIA CNS STIMULATION COAGULATION DISORDER COAGULATION TIME DECREASED COAGULATION TIME INCREASED COGWHEEL RIGIDITY COLITIS COLLAGEN DISORDER COLOR BLINDNESS CONGENITAL ANOMALY CONGESTIVE CONJUNCTIVAL EDEMA CONJUNCTIVAL ULCER CONJUNCTIVITIS CONTACT DERMATITIS COR PULMONALE CORNEAL LESION CORNEAL OPACITY CORNEAL PERFORATION CORNEAL ULCER CORONARY EMBOLISM CORONARY OCCLUSION CORONARY THROMBOSIS COUGH DECREASED COUGH INCREASED CREATINE PHOSPHOKINASE INCREASED CREATININE CLEARANCE DECREASED CREATININE INCREASED CRETINISM CRYPTOCOCCOSIS CRYSTALLURIA CUSHING'S SYNDROME CUTANEOUS MONILIASIS CYANOSIS CYST CYSTITIS DEAFNESS DEATH DEATH BY SUICIDE DEATH FETAL DECREASED ANTICOAGULANT EFFECT DECREASED URINE FLOW DEEP PHLEBITIS DEEP THROMBOPHLEBITIS DEHYDRATION DELUSIONS DEMENTIA DEPERSONALIZATION DEPRESSION DERMATITIS DERMATOMYOSITIS DIABETES INSIPIDUS DIABETES MELLITUS DIABETIC ACIDOSIS DIABETIC COMA DIARRHEA DIC DIGITALIS INTOXICATION DIPLOPIA DISCOID LUPUS ERYTHEMATOSIS DIVERTICULITIS DIVERTICULOSIS DRUG DEPENDENCE DRUG INTERACTION DRUG LEVEL DECREASED DRUG LEVEL INCREASED DRUG DRY EYES DRY MOUTH DRY SKIN DUODENAL ULCER DUODENAL ULCER HEMORRHAGE DUODENAL ULCER PERFORATION DUODENAL ULCER WITH HEMORRHAGE AND PERFORATION DUODENITIS DWARFISM DYSARTHRIA DYSAUTONOMIA DYSKINESIA DYSMENORRHEA DYSPAREUNIA DYSPEPSIA DYSPHAGIA DYSPNEA DYSTONIA DYSURIA EAR DISORDER ECCHYMOSIS ECTOPIA CORDIS ECTROMELIA ECZEMA EDEMA EJACULATION RETROGRADE ELECTROCARDIOGRAM ABNORMAL ELECTROLYTE ABNORMALITY ELECTROLYTE DEPLETION EMBOLUS EMOTIONAL LABILITY EMPHYSEMA ENANTHEMA ENCEPHALITIS ENCEPHALOCELE ENCEPHALOPATHY ENDOCARDITIS ENDOCRINE DISORDER ENDOMETRIAL CARCINOMA ENDOMETRIAL DISORDER ENDOMETRIAL HYPERPLASIA ENDOMETRIAL NEOPLASIA ENDOMETRIAL POLYP ENDOMETRIAL THICKENING ENLARGED CLITORIS ENTERITIS ENTEROCOLITIS ENZYMATIC ABNORMALITY EOSINOPHILIA EOSINOPHILIC PNEUMONIA EPENDYMITIS EPIDERMAL NECROLYSIS EPIDIDYMITIS EPISTAXIS ERUCTATION ERYTHEMA MULTIFORME ERYTHEMA NODOSUM ERYTHROID MATURATION ARREST ESOPHAGEAL HEMORRHAGE ESOPHAGEAL STENOSIS ESOPHAGEAL ULCER ESOPHAGITIS EUPHORIA EXFOLIATIVE DERMATITIS EXOPHTHALMOS EXPOSURE TO DISEASE EXTRAPYRAMIDAL SYNDROME EXTRASYSTOLES EYE DISORDER EYE HEMORRHAGE EYE PAIN FACE EDEMA FACIAL PARALYSIS FALSE POSITIVE PREGNANCY TEST FANCONI-LIKE SYNDROME FEBRILE NEUTROPENIA FECAL IMPACTION FECAL INCONTINENCE FEELING OF RELAXATION FEMINIZATION FETAL DISORDER FEVER FIBRIN DECREASED FIBRIN INCREASED FIBRINOGEN DECREASED FIBRINOGEN INCREASED FIBRINOLYSIS DECREASED FIBRINOLYSIS INCREASED FIBROCYSTIC BREAST FIXED ERUPTION FLACCID PARALYSIS FLANK PAIN FLATULENCE FLU SYNDROME FLUOROSIS FOLATE DEFICIENCY ANEMIA FOLLICULITIS FOOT DROP FUNGAL DERMATITIS FURUNCULOSIS GAMMA GLOBULINS INCREASED GAMMA GLUTAMYL TRANSPEPTIDASE INCREASED GASTRITIS GASTROENTERITIS GASTROINTESTINAL ANOMALY GASTROINTESTINAL CARCINOMA GASTROINTESTINAL DISORDER GASTROINTESTINAL HEMORRHAGE GENERALIZED EDEMA GENERALIZED GENITAL EDEMA GENITAL MONILIASIS GI NEOPLASM GI PERFORATION GIGANTISM GINGIVITIS GLAUCOMA GLOBULIN DECREASED GLOBULIN INCREASED GLOMERULITIS GLOSSITIS INCREASED GLUCOSE TOLERANCE DECREASED GLYCOSURIA GOITER DECREASED GONADOTROPINS INCREASED GOUT GRAFT VS. HOST REACTION GRAND MAL CONVULSION GRANULOCYTOSIS GRANULOMA GROWTH ACCELERATED GROWTH RETARDED GUILLAIN BARRE SYNDROME GUM HYPERPLASIA GYNECOMASTIA HAIR DISCOLORATION HAIR DISORDER HALITOSIS HANGOVER EFFECT HEALING ABNORMAL HEART ARREST HEART BLOCK HEART FAILURE HEART MALFORMATION HEAT HEINZ BODIES HEMATEMESIS HEMATURIA HEMIPLEGIA HEMOCHROMATOSIS HEMOLYTIC ANEMIA HEMOPERICARDIUM HEMOPERITONEUM HEMOPTYSIS HEMORRHAGE HEMORRHAGIC COLITIS HEMORRHAGIC CYSTITIS HEMORRHAGIC ENTEROCOLITIS HEMORRHAGIC GASTRITIS HEMORRHAGIC PANCREATITIS HEMORRHAGIC PROCTITIS HEMOTHORAX HEPATIC COMA HEPATIC INCREASED HEPATIC FAILURE HEPATIC NEOPLASIA HEPATITIS HEPATOMA HEPATOMEGALY HEPATORENAL SYNDROME HEPATOSPLENOMEGALY HERMAPHRODITISM HERNIA HERPES SIMPLEX HERPES ZOSTER HICCUP HIGH DENSITY LIPOPROTEIN DECREASED HIGH DENSITY LIPOPROTEIN INCREASED HIRSUTISM HIV INFECTION/DISEASE HIV TEST POSITIVE HOSTILITY HOT FLUSHES HYDROCEPHALUS HYDRONEPHROSIS HYDROURETER HYPALGESIA HYPERACUSIS HYPERALGESIA HYPERAMMONEMIA HYPERCALCEMIA HYPERCHLOREMIC ACIDOSIS HYPERCHLORHYDRIA HYPERCHOLESTEREMIA HYPERESTHESIA HYPERGLYCEMIA HYPERKINESIA HYPERLIPEMIA HYPERTENSIVE ENCEPHALOPATHY HYPERTHYROIDISM HYPERTROPHY HYPERURICEMIA HYPERVENTILATION HYPERVOLEMIA HYPESTHESIA HYPOACUSIS HYPOCALCEMIC TETANY HYPOCHLOREMIC ALKALOSIS HYPOCHOLESTEREMIA HYPOCHROMIC ANEMIA HYPOGLYCEMIC REACTION HYPOGONADISM FEMALE HYPOGONADISM MALE HYPOKALEMIC ALKALOSIS HYPOKINESIA HYPOLIPEMIA HYPOMAGNESEMIA HYPOMENORRHEA HYPOPHOSPHATEMIA HYPOPLASTIC ANEMIA HYPOPROTEINEMIA HYPOTHERMIA HYPOVOLEMIA HYPOXIA HYSTERIA ICHTHYOSIS ILEITIS ILEUS IMMUNE SYSTEM DISORDER IMMUNOGLOBULINS DECREASED IMMUNOGLOBULINS INCREASED IMPERFORATE ANUS IMPOTENCE INCOORDINATION INCREASED ANTICOAGULANT EFFECT INCREASED APPETITE INCREASED CAPILLARY FRAGILITY INCREASED DRUG EFFECT INCREASED SALIVATION INDIRECT COOMBS TEST POSITIVE INFECTION INFECTION BACTERIAL INFECTION FUNGAL INFECTION MASKED INFECTION PARASITIC INFECTION SUPERIMPOSED INJECTION SITE HEMORRHAGE INSOMNIA INTENTIONAL OVERDOSE INTERSTITIAL PNEUMONIA INTESTINAL GANGRENE INTESTINAL NECROSIS INTESTINAL OBSTRUCTION INTESTINAL PERFORATION INTESTINAL STENOSIS INTESTINAL ULCER INTRACRANIAL ANEURYSM INTRACRANIAL HEMORRHAGE INTRACRANIAL HYPERTENSION IODISM IRITIS ANEMIA ISCHEMIC COLITIS JAUNDICE JOINT DISORDER KERATITIS KERATOCONJUNCTIVITIS KETOSIS KIDNEY ABSCESS KIDNEY CALCULUS KIDNEY CORTEX NECROSIS KIDNEY FAILURE KIDNEY FIBROSIS KIDNEY PAIN KIDNEY TUBULAR NECROSIS KIDNEY VASCULITIS LABIAL EDEMA LABILE LACK OF DRUG EFFECT LACTATION DECREASED LACTIC ACIDOSIS LACTIC DEHYDROGENASE INCREASED LARYNGISMUS LARYNGITIS LARYNX EDEMA LE SYNDROME LEFT HEART FAILURE LEG LESION LEUKEMIA LEUKEMOID REACTION LEUKOCYTOSIS LEUKODERMA LEUKOPENIA LEUKORRHEA LIBIDO DECREASED LIBIDO INCREASED LICHENOID DERMATITIS LIPASE INCREASED LIPID PNEUMONIA LIPODYSTROPHY LIPOMA LIVER DAMAGE LIVER FUNCTION TESTS ABNORMAL LIVER NECROSIS LIVER TENDERNESS LUNG DISORDER LUNG EDEMA LUNG FIBROSIS LUNG FUNCTION DECREASED LUNG HEMORRHAGE LYMPHADENOPATHY LYMPHANGITIS LYMPHEDEMA LYMPHOCYTOSIS LYMPHOMA MALIGNANT MACROCYTIC ANEMIA MACULOPAPULAR RASH MALABSORPTION SYNDROME MALAISE MALIGNANT HYPERTHERMIA MANIC REACTION MARROW DEPRESSION MARROW HYPERPLASIA MASKED FACIES MEDIASTINAL FIBROSIS MEDICATION ERROR MEGACOLON MEGAKARYOCYTES INCREASED MEGALOBLASTIC ANEMIA MELANOSIS MELENA MENINGISM MENINGITIS MENINGOMYELOCELE MENOPAUSE MENORRHAGIA MENSTRUAL DISORDER MENTAL DETERIORATION MENTAL RETARDATION MESENTERIC ARTERIAL OCCLUSION MESENTERIC FIBROSIS MESENTERIC OCCLUSION MESENTERIC VENOUS OCCLUSION METHEMOGLOBINEMIA METHEMOGLOBINURIA METRORRHAGIA MICROCYTIC ANEMIA MIGRAINE MILIARIA MIOSIS MISCARRIAGE MONILIASIS MONOCYTOSIS MONOPLEGIA MOTOR VEHICLE ACCIDENT MOUTH ULCERATION MOVEMENT DISORDER MULTIFOCAL EXTRASYSTOLES MULTI-ORGAN FAILURE MULTIPLE CONGENITAL ANOMALIES MULTIPLE PREGNANCY MULTIPLE SCLEROSIS MUSCLE ATROPHY MUSCULAR HYPERTONIA MUSCULAR HYPOTONIA MYALGIA MYASTHENIA MYDRIASIS MYELITIS MYELOFIBROSIS MYELOID MATURATION ARREST MYELOID METAPLASIA MYELOMA MYELOPROLIFERATIVE DISORDER MYOCARDIAL FIBROSIS MYOCARDIAL INFARCT MYOCARDIAL ISCHEMIA MYOCARDITIS MYOCLONUS MYOPATHY MYOSITIS NAIL DISORDER NASAL POLYP NAUSEA AND NAUSEA VOMITING AND DIARRHEA NECK PAIN NECK RIGIDITY NECROSIS NECROTIZING PANCREATITIS NEONATAL JAUNDICE NEOPLASM NEPHRITIS NEPHROCALCINOSIS NEPHROSCLEROSIS NEPHROSIS NERVOUSNESS NEURALGIA NEURITIS NEUROLEPTIC MALIGNANT SYNDROME NEUROMA NEUROPATHY NEUROSIS NIGHT BLINDNESS NOCTURIA NODAL ARRHYTHMIA NODAL TACHYCARDIA NORMOCYTIC ANEMIA NYSTAGMUS OBESITY OCCLUSION OCULOGYRIC CRISIS OLIGURIA OPHTHALMITIS OPHTHALMOPLEGIA OPISTHOTONOS OPTIC ATROPHY OPTIC NEURITIS ORAL MONILIASIS ORCHITIS OSTEOMALACIA OSTEOMYELITIS OSTEOPOROSIS OSTEOPOROSIS FRACTURE OSTEOSCLEROSIS OTHER MUSCULOSKELETAL DISORDERS OTHER SEXUAL DYSFUNCTION FEMALE OTHER SEXUAL DYSFUNCTION MALE OVARIAN CARCINOMA OVARIAN CYST OVARIAN DISORDER OVERDOSE OVULATION FAILURE PAIN PAINFUL SWELLING PALLOR PALPITATION PANCARDITIS PANCREATITIS PANCYTOPENIA PAPILLEDEMA PARALYSIS PARANOID REACTION PARAPLEGIA PARATHYROID DISORDER PARESTHESIA PAROSMIA PAROTID GLAND ENLARGEMENT PATENT DUCTUS ARTERIOSUS PATHOLOGICAL FRACTURE PELVIC PAIN PENILE ERECTION PENIS DISORDER PEPTIC ULCER PEPTIC ULCER HEMORRHAGE PERFORATED CORNEAL ULCER PERFORATED PEPTIC ULCER PERFORATED ULCER PERICARDIAL EFFUSION PERICARDITIS PERIODONTAL ABSCESS PERIODONTITIS PERIPHERAL EDEMA PERIPHERAL GANGRENE PERIPHERAL NEURITIS PERIPHERAL VASCULAR DISORDER PERITONITIS PERMANENT DEAFNESS PERSONALITY DISORDER PETECHIA PETECHIAL RASH PHARYNGITIS PHENYLKETONURIA PHLEBITIS PHOTOPHOBIA PHOTOSENSITIVITY REACTION PILONIDAL CYST PLASMACYTOSIS PLATELET ADHESIVENESS DECREASED PLATELET ADHESIVENESS INCREASED PLEOCYTOSIS PLEURAL EFFUSION PNEUMONIA PNEUMOTHORAX POLYARTERITIS NODOSA POLYCYSTIC KIDNEY POLYCYTHEMIA POLYNEURITIS POLYSEROSITIS POLYURIA PORENCEPHALY PORPHYRIA PORPHYRINURIA POSTMATURE BIRTH POSTPARTUM HEMORRHAGE POSTURAL HYPOTENSION PR INTERVAL PROLONGED PR INTERVAL SHORTENED PREGNANCY DISORDER PREMATURE BIRTH PREMATURE EPIPHYSEAL CLOSURE PRIAPISM PROCTITIS INCREASED PROSTATE NEOPLASIA PROSTATIC CARCINOMA PROSTATIC DISORDER PROSTATIC SPECIFIC ANTIGEN DECREASED PROSTATIC SPECIFIC ANTIGEN INCREASED PROTHROMBIN DECREASED PROTHROMBIN INCREASED PRURITUS PSEUDOMEMBRANOUS COLITIS PSEUDOMEMBRANOUS ENTEROCOLITIS PSORIASIS PSYCHOTIC DEPRESSION PTOSIS PULMONARY ARTERY THROMBOSIS PULMONARY EMBOLUS PULMONARY HYPERTENSION PULMONARY INFARCT PULMONARY INFILTRATE PULMONARY MYCOSIS PULMONARY THROMBOSIS PULMONIC STENOSIS PUPILLARY DISORDER PURPURA PURPURA FULMINANS PURPURIC RASH PUSTULAR RASH PUSTULES SKIN PYELONEPHRITIS PYLORIC STENOSIS PYOGENIC ARTHRITIS PYURIA QT INTERVAL PROLONGED QT INTERVAL SHORTENED QUADRIPLEGIA RADIATION INJURY RASH REACTIVATED DUODENAL ULCER RECTAL HEMORRHAGE RED MAN'S SYNDROME REFLEXES DECREASED REFLEXES INCREASED REFRACTORY ANEMIA RENAL CARCINOMA RENAL HYPERTENSION RESPIRATORY ACIDOSIS RESPIRATORY ALKALOSIS RESPIRATORY DISORDER RESPIRATORY DISTRESS SYNDROME RESPIRATORY MONILIASIS RESPIRATORY TRACT INFECTION RETICULOENDOTHELIAL BLOCKADE RETICULOENDOTHELIAL HYPERPLASIA RETINAL ARTERY OCCLUSION RETINAL DEGENERATION RETINAL DETACHMENT RETINAL DISORDER RETINAL EDEMA RETINAL HEMORRHAGE RETINAL PIGMENTATION RETINAL VASCULAR DISORDER RETINAL VEIN THROMBOSIS RETINITIS RETROBULBAR NEURITIS RETROPERITONEAL FIBROSIS RETROPERITONEAL HEMORRHAGE RHINITIS RUPTURE OF SPLEEN RUPTURED UTERUS SALICYLISM SALIVARY GLAND ENLARGEMENT SALPINGITIS SARCOIDOSIS SARCOMA SCHIZOPHRENIC REACTION SCLERITIS SCLERODERMA SCLEROSING CHOLANGITIS SCROTAL EDEMA SEBORRHEA SEDIMENTATION RATE DECREASED SEDIMENTATION RATE INCREASED SENSORY DISTURBANCE SERUM IRON INCREASED SERUM SICKNESS SGOT INCREASED SGPT INCREASED SIALADENITIS SIALOLITHIASIS SINUS BRADYCARDIA SINUSITIS SKIN ATROPHY SKIN CARCINOMA SKIN DISCOLORATION SKIN DISORDER SKIN GRANULOMA SKIN HYPERTROPHY SKIN MELANOMA SKIN NECROSIS SKIN NODULE SKIN STRIAE SKIN ULCER SLEEP DISORDER SMALL INTESTINE PERFORATION SPASTIC PARALYSIS SPEECH DISORDER SPERMATOGENESIS ARREST SPHEROCYTOSIS SPIDER ANGIOMA SPINA BIFIDA SPLENOMEGALY SPUTUM INCREASED ST DEPRESSED ST ELEVATED STENOSIS OF COLON STENOSIS OF JEJUNUM STEVENS JOHNSON SYNDROME STILLBIRTH STOMACH ATONY STOMACH ULCER STOMATITIS STOOLS LOOSE STRABISMUS STRIDOR SUBARACHNOID HEMORRHAGE SUBCUTANEOUS EMPHYSEMA SUBCUTANEOUS NODULE SUBDURAL HEMATOMA SUDDEN DEATH SUDDEN INFANT DEATH SUICIDAL IDEATION SUICIDE ATTEMPT SUICIDE GESTURE SULFHEMOGLOBINEMIA SULFONAMIDE CRYSTALLURIA SUPRAVENTRICULAR EXTRASYSTOLES SUPRAVENTRICULAR TACHYCARDIA SWEATING SWEATING DECREASED SYNCOPE SYNDACTYLY SYNOVITIS T INVERTED TACHYCARDIA TARDIVE DYSKINESIA TASTE LOSS TASTE PERVERSION TEETH GRINDING TENDON DISORDER TENDON RUPTURE TENESMUS TENOSYNOVITIS TESTICULAR ATROPHY TETANY TETRALOGY OF FALLOT THINKING ABNORMAL THIRST THROMBIN DECREASED THROMBIN INCREASED THROMBOCYTHEMIA THROMBOCYTOPENIA THROMBOCYTOPENIC PURPURA THROMBOPHLEBITIS THROMBOSIS THROMBOTIC THROMBOCYTOPENIC PURPURA THYROID ADENOMA THYROID ATROPHY THYROID CARCINOMA THYROID DISORDER THYROID NEOPLASIA THYROIDITIS TOLERANCE DECREASED TOLERANCE INCREASED TONGUE DISCOLORATION TONGUE DISORDER TONGUE EDEMA TOOTH CARIES TOOTH DISCOLORATION TOOTH DISORDER TORSADES DE POINTES TORTICOLLIS TOXEMIA OF PREGNANCY TOXIC NEPHROPATHY TRANSPOSITION OF GREAT VESSELS TREMOR TRISMUS TUBERCULOSIS AGGRAVATED TWITCHING ULCERATIVE COLITIS ULCERATIVE ENTEROCOLITIS ULCERATIVE PROCTITIS ULCERATIVE STOMATITIS UNEXPECTED BENEFIT UNINTENDED PREGNANCY UREA CLEARANCE DECREASED UREMIC COMA URETHRAL PAIN URETHRITIS URICACIDURIA URINARY CASTS URINARY FREQUENCY URINARY HESITANCY URINARY INCONTINENCE URINARY RETENTION URINARY TRACT DISORDER URINARY TRACT INFECTION URINARY URGENCY URINE ABNORMALITY UROGENITAL NEOPLASIA UROLITHIASIS URTICARIA UTERINE ATONY UTERINE DISORDER UTERINE ENLARGEMENT UTERINE HEMORRHAGE UTERINE NEOPLASM UTERINE POLYP UTERINE SPASM UTERINE SUBINVOLUTION UVEITIS VAGINAL HEMORRHAGE VAGINAL MONILIASIS VAGINITIS VARICOSE VEIN VASCULAR ANOMALY VASCULAR DISORDER VASCULAR HEADACHE VASCULAR PURPURA VASCULITIS VASOCONSTRICTION VASODILATATION VASOSPASM VASOVAGAL EVENT VENOOCCLUSIVE LIVER DISEASE VENOSPASM VENOUS PRESSURE INCREASED VENTRICULAR ARRHYTHMIA VENTRICULAR EXTRASYSTOLES VENTRICULAR FIBRILLATION VENTRICULAR SEPTAL DEFECT VENTRICULAR TACHYCARDIA VESICULOBULLOUS RASH VESTIBULAR DISORDER VIREMIA VIRILISM VISUAL FIELD DEFECT VITAMIN TOXICITY VOCAL CORD PARALYSIS VOICE ALTERATION VOMITING VULVOVAGINAL DISORDER VULVOVAGINITIS WEIGHT GAIN WEIGHT LOSS WITHDRAWAL BLEEDING WITHDRAWAL SYNDROME WORSENING HEART FAILURE WRIST DROP XANTHOMATOSIS YAWN

Supplementary Figure 1e: 4841 MedDRA Terms

Abdominal and gastrointestinal infections Abdominal aortic aneurysm Abdominal bloating Abdominal colic Abdominal Abdominal cramps Abdominal discomfort Abdominal distension Abdominal distress Abdominal fullness Abdominal pain Abdominal pain localized Abdominal pain lower Abdominal pain upper Abdominal symptom Abducent nerve paralysis Abnormal behaviour Abnormal dreams Abnormal ejaculation Abnormal faeces Abnormal gait Abnormal glucose tolerance Abnormal hair growth Abnormal involuntary movements Abnormal labour Abnormal pigmentation Abnormal platelets Abnormal reflexes Abnormal sensation in eye Abnormal stools Abnormal thinking Abnormal vision Abortion Abortion spontaneous Abortions and stillbirth Abortions spontaneous Abrasions Abscess Abscess oral Abscess sterile Absence Absence Acalculous cholecystitis Acanthosis Acanthosis nigricans Accelerated and malignant hypertension Accelerated hypertension Accident Accident at home Accidental injury Accommodation disorder Accommodation disturbance Accommodation paralysis Accommodation spasm Acetonaemia Acetonemia Acetonuria Achalasia Achalasia cardiae Achalasia esophageal Ache Ache breast Achilles tendinitis Achilles tendon rupture Aching joints Achlorhydria Acid indigestion Acid reflux (oesophageal) Acid-base disorders Acidosis Acne Acne cystic Acne follicular Acne fulminans Acne pustular Acneiform dermatitis Acneiform eruption Acnes Acquired immunodeficiency syndromes Acrodynia Acromegaly Acute abdomen Acute allergic reaction Acute Acute and chronic pancreatitis Acute appendicitis Acute brain syndrome Acute bronchitis Acute coronary syndrome Acute generalised exanthematous pustulosis Acute generalized exanthematous pustulosis Acute intermittent porphyria Acute interstitial nephritis Acute kidney failure Acute leukaemia Acute leukemia Acute lymphoblastic leukemia Acute lymphocytic leukaemia Acute monocytic leukaemia Acute myeloblastic leukemia Acute myelocytic leukemia Acute myeloid leukaemia Acute myelomonocytic leukaemia Acute nephritic syndrome Acute pancreatitis Acute polyneuropathies Acute pulmonary edema Acute pulmonary oedema Acute renal failure Acute respiratory distress syndrome Acute Acute tonsillitis Acute tubular necrosis Adams Stokes attack Adams-Stokes syndrome Adenitis Administration site reactions Adnexa uteri mass Adnexal mass Adrenal carcinoma Adrenal cortex insufficiency Adrenal cortical insufficiency Adrenal disorder Adrenal haemorrhage Adrenal hemorrhage Adrenal hypercorticism Adrenal neoplasm Adrenal neoplasms Adrenal suppression Adrenergic syndrome Adrenocortical insufficiency acute Adult respiratory distress syndrome Adynamia Adynamic ileus Affect altered Affect lability Affect loss Affective disorder After images After taste Ageusia Aggression Aggressive behavior Aggressive reaction Aggressiveness Agitated Agitation Agitation mental Agoraphobia Agranulocytosis Air hunger Airway of anaesthesia Akathisia Akinesia Albuminuria Alcohol abuse Alcohol intolerance Alcohol Alcohol problem Alcohol withdrawal syndrome Alcoholism Alertness decreased Aleukaemic leukaemia Alkalosis Alkalosis hypochloraemic Alkalosis hypokalaemic Alkalosis respiratory Alkaptonuria Allergic conditions Allergic conjunctivitis Allergic contact dermatitis Allergic dermatitis Allergic edema Allergic granulomatous angiitis Allergic myocarditis Allergic oedema Allergic rash Allergic reaction Allergic rhinitis Allergic skin reaction Allergic vasculitis Allergy Alopecia Alopecia effluvium Alopecia reversible Alopecias Altered mood Alveolitis Alveolitis allergic Alveolitis fibrosing Amaurosis Amblyopia Amblyopia strabismic Amenorrhea Amenorrhoea Amino acid disorder Amnesia Amnesia transient Amnestic disorder Amnestic disorders Amnestic symptoms Amyloidoses Amyloidosis Amyotrophy Anaemia Anaemia aplastic Anaemia folate deficiency Anaemia haemolytic autoimmune Anaemia Heinz body Anaemia hypoplastic Anaemia macrocytic Anaemia megaloblastic Anaemia neonatal Anaemia vitamin B12 deficiency Anaesthetic complication neurological Anaesthetic complications Anal discomfort Anal fissure Anal pain Anal ulcer Anaphylactic reaction Anaphylactic responses Anaphylactic shock Anaphylactic type reaction Anaphylactoid purpura Anaphylactoid reaction Anaphylactoid shock Anaphylaxis Anasarca Anemia Anemia aplastic Anemia cobalamin deficiency Anemia folate deficiency Anemia folic acid deficiency Anemia Heinz body Anemia hemolytic Anemia hypoplastic Anemia iron deficiency Anemia megaloblastic Anemia neonatal Anemia normocytic Anemia refractory Anemia sideroblastic Aneurysm Anger Angiitis Angina at rest Angina attack Angina of effort Angina pectoris Angina pectoris aggravated Angina unstable Anginal pain Anginal syndrome Angioedema Angio-edema Angioedema and urticaria Angioedemas Angioimmunoblastic T-cell lymphoma Angioimmunoblastic T-cell lymphomas Angioneurotic edema Angioneurotic oedema Angiopathy Angle closure glaucoma Anguish Angular stomatitis Anhedonia Anhidrosis Anisocoria Anisocytosis Ankle edema Ankle sprain Ankle swelling Ankyloglossia congenital Anorectal disorder Anorexia Anorexia nervosa Anorexia nervosa and bulimia Anorgasmia Anosmia Anovulatory cycle Anoxia Anoxia cerebral Antepartum haemorrhage Antepartum hemorrhage Anterior pituitary hyperfunction Anterior pituitary hypofunction Anterior uveitis -associated diarrhea Anticholinergic syndrome Antidiuresis Antisocial behaviour Antisocial personality disorder Antisocial reaction Anuria Anxiety Anxiety attack Anxiety disorder Anxiety disorders and symptoms Anxiety neurosis Anxiety reaction Anxiety state Anxiety symptoms Anxiety-ridden Anxious mood Aortic aneurysm Aortic embolus Aortic regurgitation Aortic stenosis Aortic valve disease Aortic valve incompetence Aortic valve stenosis Apathy Aphasia Aphasia motor Aphonia Aphthous stomatitis Aplasia Aplasia bone marrow Aplasia pure red cell Aplastic anaemia Aplastic anemia Aplastic marrow Apnea Apnoea Appendicitis Appetite disorder Appetite disorders Appetite lost Appetite stimulated Application site burning Application site erythema Application site irritation Application site itching Application site pain Application site pruritus Application site reaction Apprehension Apraxia Aptyalism ARDS Areflexia Arm discomfort Arrest atrial Arrest pulmonary Arrest respiratory Arrest sinus Arrested labor Arrested labour Arrhythmia Arrhythmia atrial Arrhythmia sinus Arrhythmia supraventricular Arrhythmia ventricular Arterial aneurysm Arterial spasm Arterial thrombosis Arterial thrombosis limb Arteriosclerosis Arteriosclerosis coronary artery Arteriosclerosis Moenckeberg-type Arteriosclerosis renal Arteriosclerotic retinopathy Arteriospasm Arteriospasm coronary Arteritis Arteritis coronary Arthralgia Arthritic pains Arthritis Arthritis aggravated Arthritis bacterial Arthritis infective Arthritis rheumatoid Arthritis septic Arthropathy bite Arthrosis Arthus phenomenon Ascites Aseptic meningitis Aseptic necrosis bone Aseptic necrosis of bone Asocial behaviour Aspermia Asphyxia Aspiration Aspiration pneumonia Astasia Asterixis Asthenia Asthenic conditions Asthenopia Asthma Asthma aggravated Asthma bronchial Asthma cardiac Asthmatic attack Asthmatic crisis Astigmatism Asynergia Ataxia Ataxia cerebellar Atelectasis Atherosclerosis Athetoid Athetosis Athlete's foot Atonic urinary bladder Atopic dermatitis Atopic disorders Atrial arrhythmia Atrial fibrillation Atrial fibrillation paroxysmal Atrial flutter Atrial septal defect Atrial tachycardia Atrichia Atrioventricular block complete Atrioventricular block first degree Atrioventricular block second degree Atrophic vaginitis Atrophic vulvovaginitis Atrophy Atrophy liver Atrophy of testis Atrophy skin Attack coronary Attempted suicide Attention deficit/hyperactivity disorder Attention impaired Atypical mycobacterial infection Atypical mycobacterial infections Auditory disorder Auditory hallucinations Aura Auricular fibrillation Autism Autoimmune disorders Autoimmune hemolytic anemia Automatic bladder Autonomic dysfunction Autonomic disorders Autonomic nervous system imbalance Autonomic neuropathy Autonomic seizure AV block AV block complete AV block second degree AV dissociation Avitaminosis Awakening early Azoospermia Azotaemia Azotemia Back ache Back discomfort Back disorder Back injury Back pain Back strain Backache Bacterial infection Bacterial lower respiratory tract infections Bacterial upper respiratory tract infections Bad breath Bad dreams Bad taste Balance difficulty Balanitis Balanoposthitis Baldness Basal cell carcinoma Basophilia Basosquamous carcinoma Behavior abnormal Behavior disorder Behaviour abnormal Belching Belligerence Bell's palsy Benign and malignant breast neoplasms Benign hepatic neoplasm Benign intracranial hypertension Benign neoplasm of thyroid gland Benign ovarian tumour Benign prostatic hyperplasia Bewilderment Bigeminy Bile duct disorders Bile duct obstruction Bile duct stenosis Bile duct stone Bile duct stricture Biliary atresia Biliary cirrhosis Biliary colic Biliary pain Biliary sludge Biliary spasm Biliary stasis Biliary stones Bilirubinaemia Bilirubinemia Binocular eye movement disorder Bipolar disorder Bipolar disorders Bizarre dreams Black stools Blackheads Bladder atony Bladder calculus Bladder cancer Bladder carcinoma Bladder constriction Bladder disorder Bladder incontinence Bladder infection Bladder inflammation Bladder irritability Bladder irritation Bladder neck obstruction Bladder neoplasm Bladder neoplasms Bladder neurogenic Bladder obstruction Bladder pain Bladder papilloma Bladder paralysis Bladder retention Bladder spasm Bladder stenosis Blastomyces infections Blastomycosis Bleeding Bleeding gastric ulcer Bleeding intermenstrual Bleeding nose Bleeding tendencies Bleeding tendency Bleeding vaginal Blepharitis Blepharoconjunctivitis Blepharospasm Blindness congenital Blindness cortical Blindness day Blindness night Blindness transient Blister Blistering Blisters Bloating Block bundle branch Block heart Block neuromuscular Blood disorder Blood dyscrasia Blood in stool Blood pressure fluctuation Blood stool Bloody diarrhea Bloody stool Blotchy Blue toe syndrome Blurred vision Blurring of vision Blurry vision Body dysmorphic disorder Body image disorder Body odor Body temperature altered Body temperature conditions Bone and joint infections Bone disorder Bone infection Bone marrow aplastic Bone marrow depression Bone marrow disorder Bone marrow dysplasia Bone metabolism disorder Bone metabolism disorders Bone necrosis Bone neoplasm Bone pain Bone sarcoma Bone sarcomas Bone spur Borborygmi Borborygmus Borrelia infection Borrelial infections Bowel cramps Bowel dysfunction Bowel incontinence Bowel ischemia Bowel obstruction Bowel perforation Bowel sounds abnormal Bowen's disease Brachial artery thrombosis Bradycardia Bradycardia sinus Bradyphrenia Bradypnea Bradypnoea Brain edema Brain oedema Breast abscess Breast atrophy Breast cancer Breast cancer female Breast cancer male Breast carcinoma Breast discharge Breast discomfort Breast disorder Breast disorders Breast dysplasia Breast engorgement Breast enlargement Breast fibroadenosis Breast hyperplasia Breast infection Breast infections Breast inflammation Breast lump Breast mass Breast neoplasm Breast pain Breast size increased Breast tenderness Breast tension Breath holding Breath odor Breath odour Breathing abnormalities Breathlessness Brittle nails Bromoderma Bronchial obstruction Bronchial spasm Bronchiolitis Bronchiolitis obliterans Bronchitis Bronchitis acute Bronchitis asthmatic Bronchitis chronic Bronchoconstriction Bronchopneumonia Bronchorrhea Bronchospasm Bronchospasm on induction Bronchospasm paradoxical Bronchostenosis Bruise Bruising Bruxism Bucking Budd-Chiari syndrome Buffalo hump Bulbar palsy Bulimia Bulimia nervosa Bullous conditions Bullous dermatitis Bullous eruption Bullous keratopathy Bullous pemphigoid Bullous rash Bundle branch block Burn oesophageal Burning in throat Burning lips Burning mouth Burning sensation Burning tongue Burping Bursitis Cachexia Calcium metabolism disorder Calculus bladder Calculus ureteric Calculus urethral Calculus urinary Cancer pain Candida albicans infection Candida infections Candida vaginal Candidiasis Candiduria Capillary fragility Carcinoma Carcinoma cervix Carcinoma liver Carcinoma of lung Cardiac arrest Cardiac arrhythmia Cardiac Cardiac asthma Cardiac conduction disorders Cardiac disorder Cardiac disorders Cardiac dysrhythmias Cardiac failure Cardiac failure congestive Cardiac failure left Cardiac failure right Cardiac fibrillation Cardiac flutter Cardiac function failure Cardiac infections Cardiac insufficiency Cardiac neurosis Cardiac pain Cardiac tamponade Cardiac valve disease Cardiac valve disorders Cardiomegaly Cardiomyopathies Cardiomyopathy Cardiopulmonary arrest Cardio-respiratory arrest Cardiospasm Cardiothoracic ratio increased Cardiovascular collapse Cardiovascular disorder Carditis Caries dental Carotid artery thrombosis Carotid sinus syndrome Carpal tunnel syndrome Carpo-pedal spasm Cartilage disorders Cartilage injury Catabolic state Catabolism increased Catalepsy Cataplexy Cataract Cataract congenital Cataract cortical Cataract lenticular Cataract subcapsular Cataracts Catatonia Catatonic reaction Catatonic state Cauda equina syndrome Causalgia Cellulitis Cellulitis gangrenous disorder Central nervous system neoplasm Central retinal vein occlusion Cephalgia Cerebellar ataxia Cerebellar syndrome Cerebral artery embolism Cerebral artery thrombosis Cerebral edema Cerebral embolism Cerebral haemorrhage Cerebral hemorrhage Cerebral infarct Cerebral infarction Cerebral ischaemia Cerebral ischemia Cerebral palsy Cerebral thrombosis Cerebral vascular disturbance Cerebral vascular lesion Cerebral venous thrombosis Cerebrovascular accident Cerebrovascular disorder Cerebrovascular insufficiency Cerebrovascular spasm Cerumen impaction Cervical discharge Cervical dysplasia Cervical hypersecretion Cervical pain Cervical spasm Cervicitis Cervix carcinoma Cervix carcinoma stage 0 Cervix disorder Cervix neoplasms Chalazion Change in blood pressure Change in bowel habits Change of bowel habit Changes in physical activity Character change Character change in Charcot arthropathy Cheilitis Chemical injuries Chemical injury Chemosis Chest ache Chest discomfort Chest pain Chest pressure Chest tightness Chest wall pain Cheyne-Stokes respiration Chilliness Chills Chloasma Choking Choking sensation Cholangiolitis Cholangitis Cholangitis sclerosing Cholecystitis Cholecystitis and cholelithiasis Cholelithiasis Cholestasis Cholestasis and jaundice Cholestasis extrahepatic Cholestatic hepatic disorder Cholestatic hepatitis Cholestatic jaundice Cholestatic liver disease Cholinergic syndrome Choluria Chondrodystrophy Chondropathy Chorea Choreiform movements Choreoathetoid movements Choreoathetosis Choriocarcinoma Chorioretinitis Choroidal detachment Choroiditis Chromatopsia Chromaturia Chronic active hepatitis Chronic lymphocytic leukaemia Chronic myeloid leukaemia Chronic myelomonocytic leukaemia Chronic obstructive pulmonary disease Chronic polyneuropathies Chronic renal failure Chronic renal insufficiency Churg Strauss syndrome Ciliary muscle spasm Ciliary spasm Cinchonism Circulatory collapse Circulatory failure Circumoral paresthesia Cirrhosis biliary Cirrhosis liver Clamminess Clammy Claudication Claudication intermittent Clinical flare reaction Clonic convulsion Clonic seizures Clonic-tonic Clostridia infections Clostridial infection Clostridium colitis Clostridium difficile infection Clot blood Cloudy urine Clubbing Clubfoot Clumsiness Cluster headache CMV CNS depression CNS neoplasm Coagulation disorder Coagulation factor deficiencies Coated tongue Cognitive disorder Cognitive disturbance Cognitive function abnormal Cognitive impairment Cogwheel rigidity Cold extremities Cold feet Cold hands Cold intolerance Cold sores Cold sweat Cold symptoms Cold urticaria Coldness Colic Colic abdominal Colic biliary Colic renal Colicky Colitis Colitis aggravated Colitis hemorrhagic Colitis ischaemic Colitis pseudomembranous Colitis ulcerative Collapse of lung Collapse transient Colon cancer Colon carcinoma Colon neoplasm Colon obstruction Colon perforation Colon ulcer Colonic atony Colonic dysfunction Colonic obstruction Color blindness Colour blindness Colpitis Coma Coma hepatic Coma states Comedone Common cold Communication disorder Completed suicide Complex partial seizures Complex regional pain syndrome Concentration impaired Concentration impairment Concentration loss Condition aggravated Conduct disorder Conduction disorder Conduction disorders Conductive deafness Confabulation Confusion Confusion and disorientation Confusion state Confusional state Congenital absence of bile ducts Congenital aplastic anaemia Congenital arterial malformation Congenital cardiac disorders Congenital cystic kidney disease Congenital eye disorder Congenital genitourinary abnormality Congenital glaucomas Congenital hypertrichosis Congestion nasal Congestion pulmonary Congestive cardiomyopathy Congestive heart failure Conjunctival congestion Conjunctival disorder Conjunctival edema Conjunctival haemorrhage Conjunctival hemorrhage Conjunctival hyperaemia Conjunctival hyperemia Conjunctival injection Conjunctival oedema Conjunctival pigmentation Conjunctival redness Conjunctival ulcer Conjunctivitis Conjunctivitis allergic Conjunctivitis bacterial Conjunctivitis infective Connective tissue disorder Connective tissue disorders Consciousness abnormal Consciousness decreased Consciousness loss of Constipation Contact dermatitis Contact lens intolerance Contracture Contusion Conversion disorder Conversion reaction Convulsion Convulsion Jacksonian Convulsion neonatal Convulsions Coombs negative haemolytic anaemia Coombs positive haemolytic anaemia Coombs positive hemolytic anemia Coordination abnormal Coordination disturbance Coordination impaired Cor pulmonale Corneal clouding Corneal degeneration Corneal deposits Corneal disorder Corneal edema Corneal erosion Corneal infection Corneal injuries Corneal irritation Corneal lesion Corneal oedema Corneal opacity Corneal sensitivity decreased Corneal stromal edema Corneal ulcer Corneal ulceration Coronary artery atherosclerosis Coronary artery disease Coronary artery disorders Coronary artery insufficiency Coronary artery sclerosis Coronary artery spasm Coronary artery thrombosis Coronary insufficiency Coronary spasm Coronary thrombosis Cortical blindness Costochondritis Cough Cough decreased Cough increased Coughing Cramp Cramp abdominal Cramps Cramps in the calves Cramps leg Cramps menstrual Cranial nerve disorder Cranial nerve injuries Cranial nerve injury Cranial nerve lesion Cranial nerve paralysis Cranial neuropathy Crawling sensation Crepitations Crescendo angina Crisis hypertensive Crohn's disease Croup Croup infectious Crying Cryptogenic organizing pneumonia Crystalluria Cushingoid Cushing's syndrome Cutaneous hypersensitivity Cutaneous Cutaneous vasculitis Cyanosis Cycloplegia Cyclothymic disorder Cylindruria Cyst Cystitis Cystitis haemorrhagic Cystitis noninfective Cystoid macular edema Cytolytic hepatitis Cytomegaloviral infections Cytomegalovirus chorioretinitis Cytomegalovirus infection Cytomegalovirus retinitis Dacryostenosis acquired Damage liver Daytime sleepiness Deafness Deafness bilateral Deafness neurosensory Deafness permanent Deafness unilateral Debility Decompensation cardiac Decompensation myocardial Decreased activity Decreased appetite Decreased interest Decreased night vision Decreased physical activity levels Deep phlebitis Deep thrombophlebitis Deep vein thrombosis Defecation frequency increased Defective color vision Deficiency anaemia Deficiency mental Degeneration macular Degeneration muscle Degeneration myocardial Degeneration retinal Dehydration Deja vu Deja-vu Delayed effects of radiation Delayed recovery from anaesthesia Delayed recovery from anesthesia Delayed type hypersensitivity Deliria Delirium Delirium on emergence Delirium tremens Delusion Delusional disorder, persecutory type Delusional disorders Delusional symptoms Delusions Dementia Dementia acquired Demyelinating disorders Demyelination Dental abscess Dental caries Dependence psychological Dependent edema Depersonalisation Depersonalization Depigmentation spot Depressed level of consciousness Depressed mood Depressed reaction Depressed state Depression Depression aggravated Depression agitated Depression endogenous Depression functional Depression mental Depression neurotic Depression psychotic Depression reactive Depression respiratory Depression suicidal Depression worsened Depressive disorders Depressive reaction Depressive state Derealisation Derealization Dermal cyst Dermatitis Dermatitis acneiform Dermatitis allergic Dermatitis and eczema Dermatitis atopic Dermatitis bullous Dermatitis contact Dermatitis exfoliative Dermatitis exfoliative generalised Dermatitis fungal Dermatitis herpetiformis Dermatitis infected Dermatitis lichenoid Dermatitis medicamentosa Dermatitis pyogenic Dermatitis seborrheic Dermatographia Dermatomyositis Dermatophytosis Dermatosis Dermographia Dermographism Dermoid cyst Dermoid cyst of ovary Detached Detachment Developmental glaucoma Diabetes Diabetes insipidus Diabetes mellitus Diabetic acidosis Diabetic complications Diabetic complications renal Diaphoresis Diaphragmatic hernia Diaphragmatic hernias Diaphragmatic paralysis Diarrhea Diarrhea bloody Diarrhea hemorrhagic Diarrhoea Diarrhoea haemorrhagic Diarrhoea infectious Diarrhoea, Clostridium difficile Diastolic hypertension DIC Difficulty breathing Difficulty in micturition Difficulty in walking Difficulty sleeping Difficulty thinking Diffuse vasculitis Dilatation pupillary Dilated pupils Diplegia Diplopia Discharge conjunctivitis Discharge eye Discoid lupus erythematosis Discoloration skin Discomfort Discomfort abdominal Discomfort epigastric Disease hepatocellular Disease obstructive lung Disease Parkinson's Disinhibition Dislocation Disorder behavior Disorder eye Disorder liver Disorder lung Disorder muscle Disorder personality Disorder pulmonary Disorder sleep Disorientation Disseminated intravascular coagulation Disseminated lupus erythematosus Dissociation Dissociative disorder Dissociative disorders Dissociative fugue Dissociative reaction Dissociative states Distention Distress abdominal Distress gastrointestinal Distress respiratory Disturbance in attention Disturbances in initiating and maintaining sleep Disulfiram like reaction Diuresis Diverticula Diverticulitis Diverticulosis Diverticulum Diverticulum intestinal Dizziness Dizziness on standing up Dizziness postural Dizziness upon standing Dopiness Dorsal pain Double vision Dreamy state Drooling Drowsiness Drug administration error Drug allergy Drug eruption Drug hypersensitivity Drug interaction Drug intolerance Drug rash Drug tolerance Drug toxicity Drug withdrawal convulsions Drug withdrawal headache Drug withdrawal syndrome Drunkenness Dry cough Dry eye Dry eye syndrome Dry eyes Dry hair Dry lips Dry mouth Dry nose Dry skin Dry throat Dryness oral Dryness vaginal Duodenal obstruction Duodenal perforation Duodenal ulcer Duodenal ulcer haemorrhage Duodenal ulcer perforated Duodenal ulcer perforation Duodenitis Dysaesthesia Dysarthria Dysautonomia Dysbasia Dyschezia Dyschromatopsia Dysdiadochokinesis Dysentery Dysequilibrium Dysesthesia Dysfunction kidney Dysfunctional uterine bleeding Dysgeusia Dysgraphia Dyshidrosis Dyshidrotic eczema Dyskinesia Dyskinesia syndrome Dyskinesia tardive Dyskinetic syndrome Dyslexia Dysmenorrhea Dysmenorrhoea Dysmetria Dysmorphophobia Dysosmia Dyspareunia Dyspepsia Dysphagia Dysphasia Dysphemia Dysphonia Dysphoria Dyspnea Dyspnea exertional Dyspnoea Dyspnoea exacerbated Dyspnoea exertional Dyspnoea paroxysmal nocturnal Dyspraxia Dysrhythmias Dyssomnia Dyssomnias Dysthymic disorder Dystonia Dystonias Dystonic reaction Dysuria Ear ache Ear buzzing Ear discomfort Ear disorder Ear drum perforation Ear infection Ear infections Ear noises Ear pain Ear ringing Earache Early morning awakening Ecchymoses Ecchymosis Echolalia Ectopic beats Ectropion Eczema Eczema aggravated Eczema infected Eczematous dermatitis Eczematous rash Edema Edema brain Edema cerebral Edema conjunctival Edema dependent Edema eyelid Edema generalized Edema lip Edema lung Edema of extremities Edema of lower extremities Edema of penis Edema palpebral Edema periorbital Edema peripheral Edema pulmonary Edema retinal Edema tongue Effort angina Effort syndrome Ejaculation abnormal Ejaculation decreased Ejaculation delayed Ejaculation disorder Ejaculation failure Ejaculation premature Elastosis perforans Electrolyte abnormality Electrolyte depletion Elevated cholesterol Elevated mood Elevated triglycerides Elliptocytosis Elliptocytosis hereditary Emaciation Embolism Embolism and thrombosis Embolism venous Embolus Emesis Emotional disorder Emotional distress Emotional instability Emotional lability Emotional poverty Emotional problems Emotional reaction Emotional withdrawal Emphysema Emphysema pulmonary Emprosthotonus Enamel hypoplasia Enanthema Encephalopathies Encephalopathy Encephalopathy aluminum Endocardial fibrosis Endocarditis Endocarditis bacterial Endocrine disorder Endocrine disorders Endometrial disorder Endometriosis Endometritis Endophthalmitis Energy decreased Enlarged clitoris Enteritis Enteritis ulcerative Enterocolitis Enterocolitis haemorrhagic Enuresis Enzyme abnormality Eosinophilia Eosinophilic disorders Eosinophilic granuloma Eosinophilic leukaemia Eosinophilic myocarditis Eosinophilic pneumonia Ephelides Epidermal cyst Epidermal naevus Epidermal necrolysis Epididymitis Epigastric burning Epigastric discomfort Epigastric distress Epigastric fullness Epigastric pain Epiglottitis Epilepsy Epilepsy aggravated Epilepsy grand mal Epilepsy petit mal Epilepsy temporal lobe Epileptic seizure Epiphora Epiphyses premature fusion Episcleritis Epistaxis Epstein-Barr viral infections Epstein-Barr virus infection Erectile disturbance Erectile dysfunction Erection decreased Erection increased Erection nocturnal Erethism poisoning Erosive oesophagitis Eructation Eruption Eruptive xanthoma Erythema Erythema annulare Erythema bullosum Erythema exudativum Erythema eyelid Erythema facial Erythema induratum Erythema marginatum Erythema migrans Erythema multiforme Erythema multiforme exudativum Erythema nodosum Erythema of eyelid Erythemas Erythematous rash Erythematous skin rash Erythremic myelosis Erythrocytes agglutination Erythrocytopenia Erythrocytosis Erythroderma Erythroid maturation arrest Erythroleukaemia Erythroleukemia Erythromelalgia Erythropenia Esophageal candidiasis Esophageal carcinoma Esophageal disorder Esophageal erosions Esophageal hemorrhage Esophageal pain Esophageal perforation Esophageal spasm Esophageal stenosis Esophageal stricture Esophageal ulcer Esophageal ulceration Esophageal varices Esophagitis Esophagospasm Essential hypertension Euphoria Euphoric mood Eustachian tube disorder Eustachian tube dysfunction Exacerbation of asthma Exanthem Exanthema Excess sweating Excessive thirst Excitability Excitement Exfoliation Exfoliative conditions Exfoliative dermatitis Exfoliative rash Exhaustion Exophthalmos Exostosis Extensor plantar response Extradural haematoma Extraocular muscle disorder Extrapyramidal disorder Extrapyramidal symptoms Extrapyramidal syndrome Extrasystoles Extrasystoles atrial Extrasystoles nodal Extrasystoles supraventricular Extrasystoles ventricular Extravasation Exudative inflammation Eye abnormality Eye ache Eye burns Eye discharge Eye disorder Eye disorders Eye dryness Eye edema Eye haemorrhage Eye hemorrhage Eye infection Eye inflamed Eye inflammation Eye injury Eye irritation Eye itching Eye movement disorder Eye movement disorders Eye muscle paralysis Eye oedema Eye pain Eye pruritus Eye redness Eye strain Eye swelling Eyelid disorder Eyelid edema Eyelid oedema Eyelid ptosis Eyelid retraction Eyes dry Eyes tearing Face edema Face oedema Facial droop Facial dysmorphism Facial Facial nerve disorder Facial neuralgia Facial pain Facial palsy Facial paraesthesia Facial paralysis Facial paresis Facial paresthesia Facial rash Facial swelling Factor II deficiency Faecal incontinence Faecaloma Faeces discoloured Failed lactation Failure circulatory Failure heart Failure hepatorenal Failure kidney Failure liver Failure respiratory Failure right heart Faint Fainting Fall Falling Falling down Familial hypertriglyceridaemia Familial periodic paralysis Fanconi syndrome Fasciculation Fasciitis necrotizing Fat atrophy Fat embolism Fat tissue increased Fatigability Fatty liver Fatty stools Fear Fear symptoms Febrile convulsion Febrile disorders Febrile neutropenia Febrile reaction Fecal impaction Fecal incontinence Feeding disorder Feeling abnormal Feeling cold Feeling cool Feeling dazed Feeling down Feeling drunk Feeling high Feeling hot Feeling jittery Feeling of foreign body Feeling of relaxation Feeling of residual urine Feeling of warmth Feeling strange Feeling unreal Feeling unwell Felt faint Female orgasmic disorder Female pattern baldness Female sexual arousal disorder Femoral artery thrombosis Fertility decreased Festinating gait Fever Fever blister Fever chills Fever convulsions Fever sore Fibrillation Fibrillation atrial Fibrillation cardiac Fibrillation paroxysmal atrial Fibrillation ventricular Fibroadenoma of breast Fibrocystic breast Fibrocystic breast disease Fibromyalgia Fibromyalgia syndrome Fibromyositis Fibrosing alveolitis Fibrosis liver Finger spasticity Fixed drug eruption Fixed eruption Flaccid paralysis Flaking skin Flank pain Flashing lights Flat affect Flatulence Flatus Floaters Flu Flu symptoms Flu syndrome Fluid intake increased Fluid overload Fluid retention Flu-like symptoms Fluoride increased Fluorosis dental Flushed face Flushed skin Flushing Flutter atrial Focal seizures Foetor hepaticus Folate deficiency anemia Follicular conjunctivitis Folliculitis Foot cramps Foot drop Foot edema Foot pain Footdrop Forgetfulness Fracture Fracture bone Fracture due to osteoporosis Fractures Freckles Frequency urinary Frequent bowel movements Frigidity Fullness abdominal Fulminant hepatic failure Fumbling Fundic gland polyp Fungal dermatitis Fungal infection Fungal skin infection Furuncle Furunculosis Fuzzy Gagging Gait deviation Gait disorder Gait disturbance Gait disturbances Gait stumbling Galactorrhea Galactorrhoea Gallbladder disease Gallbladder disorder Gallbladder disorders Gallbladder inflammation Gallbladder sludge Gallbladder stone Gallbladder stones Gallstones Gangrene Gardnerella infections Gas Gas in stomach Gas pain Gasping Gastric atony Gastric bleeding Gastric cancer Gastric carcinoma Gastric haemorrhage Gastric hemorrhage Gastric inflammation Gastric irritation Gastric mucosal hypertrophy Gastric outlet obstruction Gastric pain Gastric perforation Gastric polyps Gastric ulcer Gastric ulcer haemorrhage Gastric ulcer perforation Gastrinoma Gastritis Gastritis atrophic Gastritis erosive Gastritis haemorrhagic Gastroduodenal ulcer Gastroduodenitis Gastroenteritis Gastroenteritis viral Gastroesophageal reflux Gastroesophagitis Gastrointestinal anomaly Gastrointestinal bleeding Gastrointestinal candidiasis Gastrointestinal carcinoma Gastrointestinal cramps Gastrointestinal discomfort Gastrointestinal disorder Gastrointestinal disorders Gastrointestinal disturbance Gastrointestinal fullness Gastrointestinal haemorrhage Gastrointestinal haemorrhages Gastrointestinal hemorrhage Gastrointestinal hypermotility Gastrointestinal infections Gastrointestinal injury Gastrointestinal irritation Gastrointestinal ischaemia Gastrointestinal ischemia Gastrointestinal malformation Gastrointestinal motility disorder Gastrointestinal necrosis Gastrointestinal obstruction Gastrointestinal pain Gastrointestinal perforation Gastrointestinal Gastrointestinal ulcer Gastrointestinal ulcer perforation Gastrointestinal upset Gastrooesophageal reflux disease Gastrooesophagitis Gastroparesis Gastroschisis Gaze palsy Gender disorders Gender identity disorder Generalised oedema Generalised tonic-clonic seizures Generalized aching Generalized edema Generalized itching Generalized rash Generalized spasm Genital candidiasis Genital discharge Genital edema Genital haemorrhage Genital itching Genital pruritus female Genital ulceration GI bleed GI haemorrhage GI hemorrhage GI irritation GI pain GI perforation GI upset Giant hives Giant urticaria Giddiness Gilles de la Tourette Gilles de la Tourette syndrome Gingival atrophy Gingival bleeding Gingival disorder Gingival hyperplasia Gingival hypertrophy Gingival infection Gingival pain Gingival reaction Gingival recession Gingival swelling Gingival ulceration Gingivitis Glaucoma Glaucoma aggravated Glaucoma and ocular hypertension Glomerulitis Glomerulonephritis Glomerulonephritis and nephrotic syndrome Glomerulonephritis focal Glomerulonephritis proliferative Glossal edema Glossitis Glossodynia Glottic edema Glottic spasm Glucose tolerance abnormal Glucose tolerance impaired Glucose-6-phosphate dehydrogenase deficiency Glycogen storage disease type I Glycosuria Goiter Goitre Goodpasture's syndrome Gout Gout acute Gouty arthritis Grand mal convulsion Grand mal seizure Granulocytopenia Granulocytosis Granuloma Granuloma skin Granulomatous liver disease Gravitational oedema Groggy Groin pain Growth retardation Growth retarded Growth suppression Guillain Barre syndrome Guillain-Barre syndrome Gum bleeding Gum hyperplasia Gum hypertrophy Gum pain Gynaecomastia Gynecomastia Habituation Haemangioma Haemarthrosis Haematemesis Haematochezia Haematological disorders Haematoma Haematospermia Haematuria Haemobilia Haemochromatosis Haemoconcentration Haemoglobinaemia Haemoglobinopathies Haemoglobinuria Haemolysis Haemolytic anaemia Haemolytic uraemic syndrome Haemoptysis Haemorrhage Haemorrhage subcutaneous Haemorrhage urinary tract Haemorrhagic diarrhoea Haemorrhagic diathesis Haemorrhagic disorder Haemorrhagic ovarian cyst Haemorrhagic stroke Haemorrhagic urticaria Haemorrhoidal haemorrhage Haemorrhoids Haemothorax Hair color changes Hair colour changes Hair discoloration Hair disorder Hair growth abnormal Hair growth increased Hair loss Hair texture abnormal Hair thinning Hairiness Halitosis Hallucination, auditory Hallucination, visual Hallucinations Hand and foot syndrome Hand swelling Hand-and-foot syndrome Hangover Hay fever Head discomfort Head pain Head pressure Head spinning Headache Headache aggravated Headache dull Headache histamine Headache tension Headache vascular Healing abnormal Hearing disorders Hearing impaired Hearing losses Hearing reduced Heart arrest Heart attack Heart block Heart block atrioventricular Heart disease congenital Heart disease pulmonary Heart disorder Heart failure Heart failure signs and symptoms Heart failures Heart fluttering Heart malformation Heart pounding Heart valve disorders Heartburn Heat exhaustion Heat intolerance Heat rash Heat sensitivity Heat stroke Heaviness in limbs Hebephrenia Heinz bodies Hemarthrosis Hematemesis Hematochezia Hematoma Hematopoiesis depressed Hematopoiesis increased Hematospermia Hematuria Hemeralopia Hemianopia Hemicephalgia Hemicrania Hemiparesis Hemiplegia Hemochromatosis Hemoconcentration Hemoglobinemia Hemolysis Hemolytic anemia Hemolytic reaction Hemolytic uremic syndrome Hemopericardium Hemoptysis Hemorrhage Hemorrhage aggravated Hemorrhage brain Hemorrhage esophageal Hemorrhage gastric Hemorrhage gastrointestinal Hemorrhage intracranial Hemorrhage kidney Hemorrhage lung Hemorrhage subcutaneous Hemorrhagic colitis Hemorrhagic cystitis Hemorrhagic diathesis Hemorrhagic enterocolitis Hemorrhagic gastritis Hemorrhagic ovarian cyst Hemorrhagic pancreatitis Hemorrhagic stroke Hemorrhagic urticaria Hemorrhoidal bleeding Hemorrhoids Hemospermia Hemothorax Henoch-Schonlein purpura Hepatic atrophy Hepatic cirrhosis Hepatic coma Hepatic damage Hepatic disease Hepatic failure Hepatic fibrosis Hepatic fibrosis and cirrhosis Hepatic function abnormal Hepatic function disorder Hepatic haemorrhage Hepatic infarction Hepatic insufficiency Hepatic metabolic disorders Hepatic necrosis Hepatic neoplasm Hepatic neoplasm malignant Hepatic steatosis Hepatic trauma Hepatic vein occlusion Hepatic vein thrombosis Hepatis peliosis Hepatitis Hepatitis A Hepatitis B Hepatitis cholestatic Hepatitis chronic active Hepatitis granulomatous Hepatitis infectious Hepatitis nonspecific Hepatitis toxic Hepatitis viral Hepatobiliary disease Hepatobiliary disorders Hepatobiliary neoplasms Hepatocellular damage Hepatocellular injury Hepatoma Hepatomegaly Hepatorenal failure Hepatorenal syndrome Hepatosplenomegaly Hepatotoxic effect Hepatotoxicity Hereditary spherocytosis Hermaphroditism Hernia Herpes simplex Herpes viral infections Herpes virus infection Herpes zoster Herxheimer's reaction Hesitancy Hiatal hernia Hiatus hernia Hiccough Hiccup Hiccups High feeling High frequency deafness Hirsutism Histiocytoses Hives Hoarseness Hodgkin's disease lymphocyte depletion type stage unspecified Holmes-Adie pupil Homocystinuria Hordeolum Hostility Hot flashes Hot flush Hot flushes Hydraemia Hydrarthrosis Hydronephrosis Hypalgesia Hyperacidity Hyperactive Hyperactivity Hyperacusia Hyperacusis Hyperadrenalism Hyperadrenocorticism Hyperaemia Hyperaesthesia Hyperalertness Hyperalgesia Hyperammonaemia Hyperammonemia Hyperamylasaemia Hyperamylasemia Hyperbilirubinaemia Hyperbilirubinemia Hypercalcemia Hypercalcinuria Hypercalciuria Hypercapnia Hypercarbia Hypercatabolism Hyperchloraemia Hyperchloremia Hyperchlorhydria Hypercholesteremia Hypercholesterolaemia Hypercholesterolemia Hyperchromic anaemia Hypercoagulation Hypercorticoidism Hyperemesis Hyperemia Hyperemia cerebral Hyperesthesia Hyperexcitability Hyperexcitation Hypergastrinaemia Hypergastrinemia Hyperglobulinaemia Hyperglobulinemia Hyperglycaemia Hyperglycaemic hyperosmolar nonketotic syndrome Hyperglycemia Hyperglycemic hyperosmolar nonketotic syndrome Hyperhemoglobinemia Hyperhidrosis Hyperinsulinaemia Hyperinsulinism Hyperkalaemia Hyperkalemia Hyperkeratoses Hyperkeratosis Hyperkinesia Hyperkinesis Hyperkinetic reaction Hyperkinetic syndrome Hyperlactacidaemia Hyperlipaemia Hyperlipemia Hyperlipidaemia Hyperlipidemia Hyperlipoproteinemia Hypermagnesaemia Hypermagnesemia Hypermenorrhea Hypermetabolism Hypernatraemia Hypernatremia Hyperorexia Hyperostosis Hyperparathyroid disorders Hyperphagia Hyperphosphataemia Hyperphosphatemia Hyperpigmentation disorders Hyperpigmentation skin Hyperpituitarism Hyperplasia breast Hyperpnea Hyperpotassemia Hyperprolactinaemia Hyperprolactinemia Hyperproteinaemia Hyperproteinemia Hyperpyrexia Hyperreflexia Hypersalivation Hypersecretion gastric Hypersensitivity Hypersensitivity reaction Hypersensitivity syndrome Hypersensitivity vasculitis Hypersomnia Hypertension Hypertension aggravated Hypertension complications Hypertension diastolic Hypertension exacerbated Hypertension intracranial Hypertension malignant Hypertension ocular Hypertension portal Hypertension pulmonary Hypertension rebound Hypertension renal Hypertensive crisis Hypertensive encephalopathy Hypertensive episode Hypertensive nephropathy Hyperthermia Hyperthermia malignant Hyperthyroidism Hypertonia Hypertonic bladder Hypertonicity Hypertonus Hypertrichoses Hypertrichosis Hypertriglyceridaemia Hypertriglyceridemia Hypertrophic cardiomyopathy Hypertrophic obstructive cardiomyopathy Hypertrophy breast Hyperuricaemia Hyperuricemia Hyperuricosuria Hyperventilation Hypervigilance Hypervolaemia Hypervolemia Hypesthesia Hypoactivity Hypoacusis Hypoadrenalism Hypoaesthesia Hypoaesthesia oral Hypoalbuminaemia Hypoalbuminemia Hypocalcaemia Hypocalcemia Hypochloraemia Hypochloremia Hypochlorhydria Hypocholesteremia Hypocholesterolaemia Hypocholesterolemia Hypochondriacal personality Hypochondriasis Hypochromic anaemia Hypochromic anemia Hypocoagulable state Hypoesthesia Hypofibrinogenemia Hypogeusia Hypoglobulinaemia Hypoglobulinemia Hypoglycaemia Hypoglycaemic coma Hypoglycaemic reaction Hypoglycemia Hypoglycemic coma Hypoglycemic reaction Hypohidrosis Hypokalaemia Hypokalaemic alkalosis Hypokalaemic syndrome Hypokalemia Hypokalemic alkalosis Hypokalemic syndrome Hypokinesia Hypolipemia Hypolipidaemia Hypolipoproteinemia Hypomagnesaemia Hypomagnesemia Hypomenorrhea Hypomenorrhoea Hyponatraemia Hyponatraemic syndrome Hyponatremia Hypoparathyroid disorders Hypophosphataemia Hypophosphatemia Hypopituitarism Hypoplastic anaemia Hypoplastic anemia Hypopnea Hypopnoea Hypopotassemia Hypoproteinaemia Hypoproteinemia Hypoprothrombinaemia Hypoprothrombinemia Hyporeflexia Hypotension Hypotension aggravated Hypotension asymptomatic Hypotension orthostatic Hypotension postural Hypotensive episode Hypothermia Hypothyroidism Hypotonia Hypotonic urinary bladder Hypotrichosis Hypotriglyceridaemia Hypotriglyceridemia Hypoventilation Hypovitaminosis Hypovolaemia Hypovolaemic shock Hypovolemia Hypovolemic shock Hypoxaemia Hypoxemia Hypoxia Hysteria Ichthyoses Ichthyosis Ichthyosis acquired Icterus Idiocy Idiopathic pulmonary fibrosis Idiopathic thrombocytopenic purpura Idiopathic urticaria IIIrd nerve paralysis IIIrd nerve paresis Ileal ulcer Ileitis Ileus Ileus paralytic Iliac artery thrombosis Ill-defined disorder Illusion Immediate hypersensitivity reaction Immune system disorder Immune system disorders Immunodeficiency Immunodeficiency syndromes Impaction fecal Impaired gastric emptying Impaired healing Impaired liver function Impaired renal function Impetigo Impotence Impotent Impotentia erigendi Impulse control disorders Impulse-control disorder Impulsive behavior Impulsive behaviour Inanition Inappetence Inappropriate ADH secretion Inappropriate affect Inappropriate antidiuretic hormone secretion Inappropriate laughter Inborn errors of amino acid metabolism Inborn errors of lipid metabolism Inborn errors of metabolism Incoherent Incontinence Incontinence fecal Incontinence urinary Incoordination Increased appetite Increased bronchial secretion Increased intracranial pressure Increased intracranial pressure and hydrocephalus Increased libido Increased reflexes Increased salivation Increased thirst Increased upper airway secretion Increased urinary frequency Indifference Indigestion Infarct cerebral Infarct myocardial Infarction Infected eczema Infection Infection bacterial Infection fungal Infection mycotic Infection parasitic Infection staphylococcal Infection viral Infections and infestations Infectious arthritis Infectious diarrhea Infectious mononucleosis Infertility Infertility male Infiltration fatty liver Inflammation Inflammation localized Inflammations Inflammatory bowel disease Inflammatory edema reaction Inflammatory swelling Inflicted injury Influenza Influenza like illness Influenza viral infections Influenza-like symptoms Infusion site burning Infusion site erythema Infusion site pain Ingrowing nail Ingrown toe nail Injection site bleeding Injection site bruising Injection site burning Injection site ecchymosis Injection site erythema Injection site haemorrhage Injection site hematoma Injection site hemorrhage Injection site infection Injection site inflammation Injection site irritation Injection site mass Injection site oedema Injection site pain Injection site phlebitis Injection site pruritus Injection site rash Injection site reaction Injection site redness Injection site swelling Injection site tenderness Injury Injury asphyxiation Injury corneal Injury NOS Injury to kidney Injury to liver Inner ear disorder Inner ear infection Insomnia Instability cardiovascular Instability gait Insufficiency cardiac Insufficiency pituitary Insufficiency renal Insulin autoimmune syndrome Insulin shock Intention tremor Intentional overdose Intentional self-injury Interactions Intermenstrual bleeding Intermittent claudication Interstitial fluid increased Interstitial lung disease Interstitial nephritis acute Interstitial pneumonia Interstitial pneumonitis Interstitial pulmonary fibrosis Intestinal functional disorder Intestinal gangrene Intestinal haemorrhage Intestinal haemorrhages Intestinal hemorrhage Intestinal hypermotility Intestinal infarction Intestinal infections Intestinal ischaemia Intestinal ischemia Intestinal mass Intestinal necrosis Intestinal obstruction Intestinal perforation Intestinal stenosis Intestinal stricture Intestinal ulcer Intestinal ulceration Intoxication Intra-abdominal haemorrhage Intracranial hemorrhage Intracranial hypertension Intracranial pressure increased Intracranial venous sinus thrombosis Intravascular haemolysis Intravascular hemolysis Intraventricular block Involuntary muscle movement Iridocyclitis Iris atrophy Iritis Iron deficiencies Iron deficiency Iron deficiency anaemia Iron deficiency anemia Iron excess Irrational Irresponsibility Irritability Irritable Irritable bowel syndrome Irritable colon Irritation eye Irritation gastric Irritation skin Ischaemia Ischaemic optic neuropathy Ischemia Ischemia bowel Ischemia cerebral Ischemia cerebrovascular Ischemia myocardial Ischemia peripheral Ischemia retinal Ischemic colitis Ischemic heart disease Isosthenuria Itch Itching Itching eyes Itchy Itchy eyes Jacksonian epilepsy Jacksonian seizures Jarisch-Herxheimer reaction Jaundice Jaundice acholuric Jaundice cholestatic Jaundice hemolytic Jaundice neonatal Jaw pain Jaw stiffness Jejunal ulcer Jejunal ulcer perforation Jitteriness Joint ache Joint dislocations Joint disorder Joint disorders Joint effusion Joint inflammation Joint pain Joint related signs and symptoms Joint sprain Joint stiffness Joint swelling Joint tightness Jumpiness Junctional tachycardia Kawasaki's disease Keloid Keloid scar Keratitis Keratitis sclerosing Keratitis sicca Keratoconjunctivitis Keratoconjunctivitis sicca Keratopathy Keratosis Ketoacidosis Ketonuria Ketosis Kidney abscess Kidney calculus Kidney dysfunction Kidney failure Kidney failure acute Kidney failure chronic Kidney pain Kidney polycystic Kidney small Kidney stone Kidney tubular necrosis Klebsiella infection Klebsiella infections Klebsiella sepsis Knee pain Kussmaul respiration Labile hypertension Labor abnormal Labor prolonged Laboured breathing Labyrinthine disorder Labyrinthitis Lack of coordination Lack of feeling Lacrimal disorder Lacrimal duct obstruction Lacrimation Lacrimation decreased Lacrimation increased Lactation decreased Lactation disorder Lactation disorders Lactation induced Lactation male Lactation suppressed Lactic acidosis Lactose intolerance Langerhans' cell granulomatosis Large intestinal ulcer Large intestine carcinoma Large intestine perforation Laryngeal cancer Laryngeal edema Laryngeal neoplasm Laryngeal oedema Laryngeal spasm Laryngismus Laryngitis Laryngospasm Laryngotracheal edema Laryngotracheal oedema Larynx edema Larynx oedema Lassitude Latent diabetes LE syndrome Learning disorder Learning disorders Left ventricular failure Left ventricular failures Leg cramps Leg edema Leg pain Leg spasticity Leiomyoma Lens abnormality, congenital Lens disorder Lens opacity Lenticular opacities Leriche syndrome Lesion corneal Lethargy Leucocoria Leucopenia Leukaemia Leukaemia acute Leukaemia cutis Leukaemia granulocytic Leukaemia monocytic Leukaemia neonatal Leukaemia plasmacytic Leukaemias Leukaemias chronic myeloid Leukaemoid reaction Leukemia Leukemia acute Leukemia cutis Leukemia eosinophilic Leukemia granulocytic Leukemia lymphatic Leukemia lymphoid Leukemia myeloid Leukemia stem cell Leukemoid reaction Leukocoria Leukocytoclastic vasculitis Leukocytosis Leukocyturia Leukoderma Leukoerythroblastic anaemia Leukoerythroblastosis Leukonychia Leukopenia Leukoplakia Leukorrhea Libido decreased Libido disorder Libido increased -like eruption Lichen simplex Lichenoid dermatitis Lichenoid keratosis Ligament Ligament disorders Light headedness Light-headed Light-headed feeling Lightheadedness Limb discomfort Lip dry Lip edema Lip ulceration Lipid metabolism disorder Lipid metabolism disorders Lipodystrophies Lipohypertrophy Lipoma Lipoprotein deficiency Listless Listlessness Livedo reticularis Liver and spleen enlargement Liver carcinoma Liver cell damage Liver cirrhosis Liver damage Liver disorder Liver enlargement Liver failure Liver fatty Liver fatty change Liver fatty degeneration Liver fatty infiltration Liver fatty metamorphosis Liver necrosis Liver tenderness Liver tumor Lobar pneumonia Localised oedema Localised skin reaction Localized edema Lockjaw Loeffler's syndrome Logorrhoea Loin pain Loose bowels Loose stools Loss of consciousness Loss of interest Loss of libido Loss of memory Loss of skin elasticity Loss of smell Loss of taste Loss of vision Loss of voice Low blood pressure Lower abdominal pain Lower nephron nephrosis Lower respiratory tract infection Lower urinary tract infection Lumbago Lumbar puncture headache Lung cancer Lung disease Lung disease obstructive Lung disorder Lung edema Lung fibrosis Lung fibrosis interstitial Lung infiltration Lung neoplasm Lung neoplasm malignant Lung nodule Lupus erythematosus Lupus erythematosus systemic Lupus miliaris disseminatus faciei Lupus syndrome Lupus-like syndrome Lyell's syndrome Lymph node disorder Lymph nodes enlarged Lymphadenitis Lymphadenitis, cervical Lymphadenopathy Lymphangiopathies Lymphangitis Lymphedema Lymphocytic leukaemia Lymphocytopenia Lymphocytosis Lymphoedema Lymphoma Lymphomas Hodgkin's disease Lymphopenia Macrocytic anemia Macrocytosis Macular degeneration Macular edema Macular oedema Macular rash Macule Maculo-papular exanthema Maculopapular rash Maculo-papular rash Maculopathy metabolism disorder Major depression Malabsorption Malabsorption conditions Malabsorption syndromes Malaise Male pattern baldness Malignant breast neoplasm Malignant hypertension Malignant liver tumor Malignant melanoma Malignant ovarian cyst Malignant soft tissue neoplasm Mania acute Manic episode Manic excitement Manic psychosis Manic reaction Marrow depression Marrow depression of Marrow hypercellular Marrow hyperplasia Marrow hypoplasia Masculinization Mask like facies Masked facies Mastalgia Mastitis Mastodynia Meconium ileus Meconium plug syndrome Medication error Medication errors Megacolon Megaloblastic anemia Melaena Melancholia Melanocytic naevus Melanocytic nevus Melanoderma Melanodermia Melanoma Melanosis Melanosis coli Melasma Melena Memory disturbance Memory impaired Memory impairment Memory loss Memory loss of Mendelson's syndrome Meniere's disease Meniere's syndrome Meningism Meningismus Meningitis Meningitis aseptic Menometrorrhagia Menopausal disorder Menopausal symptoms Menopausal syndrome Menopause premature Menorrhagia Menses delayed Menses irregular Menses lack of Menstrual cramp Menstrual cycle abnormal Menstrual disorder Menstrual irregularity Menstruation delayed Menstruation increased Menstruation irregular Mental confusion Mental deficiency Mental deterioration Mental disorder Mental distress Mental dullness Mental impairment Mental retardation Mental retardation severity unspecified Mental retardations Mesenteric arterial occlusion Mesenteric artery embolism Mesenteric artery thrombosis Mesenteric occlusion Mesenteric vascular insufficiency Mesenteric vein thrombosis Mesenteric venous occlusion Mesotheliomas Metabolic acidosis Metabolic alkalosis Metabolic bone disorders Metabolic disorder Metastases Metastasis Metastatic neoplasm Meteorism Methaemoglobinaemia Methemoglobinemia Metrorrhagia Microangiopathic haemolytic anaemia Microangiopathic hemolytic anemia Microcytic anaemia Microcytic anemia Microhemorrhage Microscopic hematuria Micturition disorder Micturition frequency Micturition frequency decreased Micturition urgency Middle ear effusion Migraine Migraine aggravated Migraine headaches Migraine without aura Miliaria Miosis Miscarriage Mitral insufficiency Mitral regurgitation Mitral valve disease Mitral valve incompetence Mitral valve sclerosis Mitral valve stenosis Molluscum contagiosum Monarthritis Moniliasis Monocytosis Mononeuropathies Mononeuropathy Monoplegia Mood altered Mood change Mood depression Mood disorder NOS Mood swings Moon face Morbilliform eruption Morbilliform rash Morose Moroseness Motion sickness Motor activity retarded Motor dysfunction Motor neuron disease Motor neurone disease Motor neurone diseases Motor restlessness Mottled pigmentation Mottled skin Mouth dry Mouth haemorrhage Mouth irritation Mouth pain Mouth paresthesia Mouth ulcer Mouth ulceration Movement disorder Movements abnormal Movements involuntary Movements reduced Mucha-Habermann disease Muco-cutaneo-ocular syndrome Mucosal discoloration Mucosal discolouration Mucosal haemorrhage Mucosal hemorrhage Mucosal inflammation Mucosal ulceration Mucositis Mucositis oral Multiple myeloma Multiple myelomas Multiple sclerosis Muscle ache Muscle atrophy Muscle contractions involuntary Muscle contracture Muscle cramp Muscle cramps Muscle damage Muscle degeneration Muscle discomfort Muscle disorder Muscle disorders Muscle fasciculation Muscle fibrillation Muscle haemorrhage Muscle injuries Muscle injury Muscle necrosis Muscle pain Muscle pains Muscle relaxation Muscle rigidity Muscle soreness Muscle spasm Muscle Muscle spasticity Muscle stiffness Muscle strain Muscle twitch Muscle twitching Muscle Muscular hyperactivity Muscular incoordination Muscular pain Muscular spasm Muscular unrest Muscular weakness Musculoskeletal discomfort Musculoskeletal disorder Musculoskeletal pain Musculoskeletal stiffness Mutism Myalgia Myasthenia Myasthenia gravis Myasthenia gravis aggravated Myasthenia gravis-like syndrome Myasthenias Myasthenic syndrome Mycobacterial infection Mydriasis Myelodysplastic syndrome Myelodysplastic syndromes Myelofibrosis Myeloid leukaemia Myeloid maturation arrest Myelopathy Myeloproliferative disorder Myelosuppression Myocardial contraction decreased Myocardial decompensation Myocardial disorder Myocardial disorders Myocardial infarct Myocardial infarction Myocardial ischaemia Myocardial ischemia Myocardial rupture Myocarditis Myoclonic jerks Myoclonus Myoglobinuria Myopathies Myopathy Myopathy steroid Myopathy toxic Myopia Myositis Myxedema Nail avulsion Nail bed infection Nail changes Nail discoloration Nail discolouration Nail disorder Nail growth abnormal Nail tinea Narcolepsy Narcolepsy and hypersomnia Nasal burning Nasal congestion Nasal discharge Nasal discomfort Nasal disorder Nasal dryness Nasal inflammation Nasal irritation Nasal itching Nasal mucosal swelling Nasal mucus increased Nasal oedema Nasal polyp Nasal polyps Nasal septum perforation Nasal sinus congestion Nasal stuffiness Nasopharyngitis Nausea Nausea and vomiting symptoms Nauseous Neck discomfort Neck edema Neck injury Neck pain Neck rigidity Neck stiffness Necrosis Necrosis bone Necrosis bowel Necrosis ischaemic Necrosis ischemic Necrosis liver Necrosis skin Necrotising colitis Necrotising fasciitis Necrotizing enterocolitis Necrotizing vasculitis Neonatal and perinatal conditions Neonatal jaundice Neonatal leukaemia Neonatal respiratory disorders Neonatal respiratory distress syndrome Neoplasm Neoplasm malignant Neoplasm prostate Neoplasm skin Nephritis Nephritis haemorrhagic Nephritis interstitial Nephrocalcinosis Nephrogenic diabetes insipidus Nephrolithiasis Nephropathies Nephropathy Nephropathy toxic Nephrosclerosis Nephrosis Nephrotic syndrome Nerve compression Nerve damage Nerve deafness Nerve injury Nerve pain Nerve paralysis Nerve root lesion Nervous Nervous system disorder Nervous system disorders Nervous tension Nervousness Neuralgia Neuralgia facial Neuralgia trigeminal Neurasthenia Neuritis Neuritis optic Neurodermatitis Neurogenic bladder Neuroleptic malignant syndrome Neurologic changes Neurologic reaction Neurologic symptoms Neurological symptom Neuromuscular block Neuromuscular blockade Neuromuscular disorders Neuromuscular junction dysfunction Neuromyopathy Neuronitis Neuropathic arthropathy Neuropathy Neuropathy peripheral Neuroretinitis Neurosis Neurotic reaction Neurotoxicity Neurotoxicity NOS Neutropenia Neutropenias Neutropenic colitis Neutropenic enterocolitis Neutropenic fever Neutropenic infection Nevus Nicotinic acid deficiency Night blindness Night sweat Night sweats Night terrors Nightmare Nightmares Nipple discharge Nipple pain Nocturia Nocturnal confusion Nodal arrhythmia Nodal rhythm Nodular vasculitis Non-cardiac chest pain Non-cardiogenic pulmonary oedema Nonspecific chest pain Normochromic normocytic anaemia Normocytic anemia Nose bleed Nose bleeds Nose congestion Nose edema Nosebleed Nuchal rigidity Numbness Numbness in toes Numbness of extremities Numbness of fingers Numbness of limbs Numbness of tongue Nyctalopia Nystagmus Obesity Obliterative bronchiolitis Obsession Obsessive rumination Obsessive thoughts Obsessive-compulsive disorder Obsessive-compulsive reaction Obstipation Obstruction bowel Obstruction bronchial Obstruction colon Obstruction duodenal Obstruction gastric Obstruction intestinal Obstructive airways disorder Obstructive uropathy Occlusion mesenteric Occlusion retinal vein Ocular discomfort Ocular hemorrhage Ocular hyperaemia Ocular hypertension Ocular injuries Ocular stinging Oculogyration Oculogyric crisis Oculomotor nerve paralysis Oculomucocutaneous syndrome Oddi's sphincter spasm Odynophagia Oedema Oedema cerebral Oedema genital Oedema mouth Oedema peripheral Oesophageal achalasia Oesophageal candidiasis Oesophageal carcinoma Oesophageal disorder Oesophageal haemorrhage Oesophageal infection Oesophageal obstruction Oesophageal pain Oesophageal perforation Oesophageal spasm Oesophageal stenosis Oesophageal ulcer Oesophageal varices Oesophagitis Oily skin Olecranon bursitis Oligomenorrhea Oligomenorrhoea Oligospermia Oliguria Onychia Onycholysis Onychomycosis Onychorrhexis Ophthalmitis Ophthalmoplegia Opisthotonos Opisthotonus Oppression Optic atrophy Optic ischaemic neuropathy Optic nerve injury Optic neuritis Optic neuritis retrobulbar Optic neuropathy Oral candidiasis Oral discomfort Oral dryness Oral hemorrhage Oral lesion Oral moniliasis Oral mucosa pain Oral pain Oral soft tissue disorder Oral thrush Oral ulceration Orbital edema Orbital oedema Orchitis Orchitis noninfective Orofacial dyskinesia Oropharyngeal candidiasis Oropharyngitis Orthopnea Orthopnoea Orthostatic dizziness Orthostatic hypotension Osteoarthropathies Osteoarthropathy Osteolysis Osteomalacia Osteomyelitis Osteonecrosis Osteoporosis Osteoporosis fracture Osteoporosis with fracture Osteoporotic fracture Osteosclerosis Otalgia Otitis Otitis externa Otitis media Otosalpingitis Otosclerosis Ototoxicity Ovalocytosis Ovarian cancer Ovarian carcinoma Ovarian cyst Ovarian disorder Ovarian enlargement Overdose Overdose effect Overdoses Oversedation Ovulation delayed Ovulation failure Ozena Pain Pain abdominal Pain after application Pain aggravated Pain back Pain biliary Pain bone Pain breast Pain chest Pain during injection Pain gum Pain in arm Pain in extremity Pain in face Pain in foot Pain in hand Pain in hip Pain in jaw Pain in joint Pain in limb Pain in thoracic spine Pain injection site Pain jaw Pain joint Pain kidney Pain knee Pain muscle Pain of lower extremities Pain of skin Pain pelvic Pain throat Pain urethral Painful defaecation Painful defecation Painful intercourse Painful joints Painful red eyes Painful urination Pale skin Palilalia Pallor Palmar-plantar erythrodysaesthesia syndrome Palmar-plantar erythrodysesthesia syndrome Palpitation Palsy Palsy cerebral Pancarditis Pancreatitis Pancreatitis acute Pancreatitis haemorrhagic Pancytopenia Panic attack Panic disorder Panic disorders Panic reaction Panic symptoms Panmyelosis Panniculitides Panniculitis Panophthalmitis Papillary necrosis renal Papilledema Papillitis Papilloedema Papular rash Papular skin eruption Papule Papulosquamous rash Papulovesicular rash Paradoxical bronchospasm Paradoxical pressor response Paraesthesia Paraesthesia oral Paraesthesias and dysaesthesias Parageusia Paralysis Paralysis agitans Paralysis bulbar Paralysis facial Paralysis flaccid Paralysis vocal cord Paralytic ileus Paranoia Paranoid personality disorder Paranoid reaction Paranoid traits Paraplegia Parasomnia Parasomnias Parathyroid disorder Parathyroid gland disorders Paresis Paresthesia Paresthesia of limbs Paresthesia skin Parkinsonian gait Parkinsonian-like tremor Parkinsonism Parkinson's disease Parkinson's disease and parkinsonism Parkinson's syndrome Paroniria Paronychia Parosmia Parotid enlargement Parotid gland enlargement Parotid pain Parotid swelling Parotitis Paroxysmal atrial tachycardia Paroxysmal nocturnal dyspnea Paroxysmal nocturnal haemoglobinuria Paroxysmal nocturnal hemoglobinuria Paroxysmal ventricular tachycardia Partial complex seizures Partial seizures Passed out Pathological fracture Pedal edema Peeling Peliosis hepatis Peliosis hepatitis Pellagra Pelvic inflammation Pelvic inflammatory disease Pelvic pain Pemphigoid Penis disorder Peptic ulcer Peptic ulcer haemorrhage Peptic ulcer hemorrhage Peptic ulcer pain Peptic ulcer perforation Peptic ulceration Perception disturbances Perforated gastric ulcer Perforated peptic ulcer Perforation gastrointestinal Perforation of uterus Perianal abscess Perianal irritation Periarteritis nodosa Pericardial disorders Pericardial effusion Pericardial haemorrhage Pericarditis Perineal pain Periodontal abscess Periodontal disease Periodontitis Perioral dermatitis Perioral numbness Periorbital edema Periorbital oedema Periorbital swelling Periostitis Peripheral circulatory failure Peripheral coldness Peripheral edema Peripheral embolism Peripheral gangrene Peripheral ischaemia Peripheral ischemia Peripheral motor neuropathy Peripheral nerve palsy Peripheral neuritis Peripheral neuropathies Peripheral occlusive disease Peripheral sensory neuropathy Peripheral swelling Peripheral vascular disease Peripheral vascular disorder Peripheral vasodilatation Peristalsis visible Peritonitis Peritonsillar abscess Perleche Pernicious anaemia Peroneal nerve palsy Persecutory delusion Persistent generalised lymphadenopathy Personality change Personality disorder Petechia Petechiae Petechial rash Petit mal Petit mal epilepsy Peyronie's disease Pharyngeal edema Pharyngeal oedema Pharyngitis Pharyngitis streptococcal Pharyngolaryngeal pain Phenylketonuria Phimosis Phlebitis Phlebitis deep Phlebitis superficial Phlebothrombosis Phlegm Phobia metabolism disorders Photodermatosis Photophobia Photopsia Photosensitive dermatitis Photosensitive rash Photosensitive reaction Photosensitivity Photosensitivity reaction Photosensitized Phototoxicity Phyma Physical deconditioning Pica PIE syndrome Pigmentation disorder Pigmentation disorders Pigmentation skin Pigmented naevus Pigmented nevus Piloerection Pin-point pupils Pins and needles Pitting edema Pitting oedema Pituitary apoplexy Pituitary haemorrhage Pituitary insufficiency Pituitary-dependent Cushing's syndrome Pityriasis lichenoides et varioliformis acuta Pityriasis rosea Plantar fasciitis Plasma cell neoplasms Plasmacytoma Platelet changes Platelet disorder Platelet disorders Platelets abnormal Pleural disorders Pleural effusion Pleural fibrosis Pleural haemorrhage Pleural mesothelioma Pleural neoplasm Pleural neoplasms Pleural pain Pleurisy Pleuritic pain Pleuritis Pleurodynia Pleurothotonus Pneumatosis cystoides intestinalis Pneumatosis intestinalis Pneumoconiosis Pneumocystis carinii pneumonia Pneumocystis infections Pneumocystis jiroveci pneumonia Pneumonia Pneumonia aspiration Pneumonia interstitial Pneumonia klebsiella Pneumonia pneumococcal Pneumonitis Pneumonitis allergic Pneumothorax Podagra Poisoning Poisoning and toxicity Poliomyelitis Pollakiuria Polyarteritis nodosa Polyarthralgia Polyarthritis Polycythaemia Polycythemia Polydipsia Polydypsia Polymenorrhagia Polymenorrhoea Polymorphonuclear leucocytosis Polymorphonuclear leukocytosis Polymyalgia rheumatica Polymyositis Polyneuritis Polyneuropathy Polyomavirus infections Polyphagia Polyuria Porphyria Porphyria acute Porphyria cutanea tarda Porphyria hepatic Porphyria non-acute Porphyrin metabolism disorder Portal hypertension Portal vein thrombosis Post procedural complication Post procedural haemorrhage Post procedural pain Post spinal headache Posterior nasal drip Posterior pituitary disorders Posterior subcapsular cataract Postmenopausal bleeding Postmenopausal haemorrhage Postnasal drip Postoperative complication Postoperative pain Postpartum haemorrhage Postpartum hemorrhage Postpartum venous thrombosis Postural hypotension Potassium deficiency Potassium imbalance Precocious puberty Precordial pain Premature atrial contraction Premature beats Premature ejaculation Premature epiphyseal closure Premature menopause Premature ventricular contractions Premenstrual syndrome Premenstrual tension Preretinal fibrosis Pressure chest Presyncope Priapism Primary hypothyroidism Primary pulmonary hypertension Prinzmetal angina Proarrhythmia Procedural pain Proctalgia Proctitis Proctitis ulcerative Proctocolitis Productive cough Profound mental retardation Progressive bulbar palsy Progressive multifocal leukoencephalopathy Prolonged labour Proptosis Prostate cancer Prostate carcinoma Prostatic disorder Prostatic hypertrophy Prostatitis Prostration Proteinuria Prurigo Pruritis Pruritus Pruritus ani Pruritus generalised Pruritus genital Pruritus vulvae Pseudo lymphoma Pseudocroup Pseudolymphoma Pseudomembranous colitis Pseudomembranous enterocolitis Pseudoparkinsonism Pseudotumor cerebri Psoriasis Psoriasis flare-up Psychiatric disorders Psychiatric symptom Psychic disturbance Psychomotor epilepsy Psychomotor excitability Psychomotor hyperactivity Psychomotor restlessness Psychomotor seizures Psychoneurosis Psychopathic personality Psychophysiologic reaction Psychosexual disorder Psychosis Psychosis depressive Psychosis manic Psychosomatic disease Psychotic behaviour Psychotic depression Psychotic disorder Psychotic episode Psychotic state Ptosis Ptyalism Pulmonary arrest Pulmonary artery thrombosis Pulmonary carcinoma Pulmonary collapse Pulmonary congestion Pulmonary disorder Pulmonary edema Pulmonary embolism Pulmonary embolism and thrombosis Pulmonary embolus Pulmonary eosinophilia Pulmonary fibrosis Pulmonary haemorrhage Pulmonary hemorrhage Pulmonary hypertension Pulmonary hypertensions Pulmonary infarct Pulmonary infarction Pulmonary infiltration Pulmonary irritation Pulmonary oedema Pulmonary oedemas Pulmonary thrombosis Pulmonary toxicity Pulmonary vascular disorder Pulmonary vascular disorders Pulsus bigeminus Punctate keratitis Pupil disorders Pupillary disorder Pupillary reflex impaired Pupillary signs Pupillotonia Pupils constricted Pupils dilated Pupils unequal Purine and metabolism disorders Purple toes syndrome Purpura Purpura allergic Purpura fulminans Purpuric rash Pustular rash Pustule Pyelonephritis Pyelonephritis acute Pyloric stenosis Pylorospasm Pyoderma Pyoderma gangrenosum Pyogenic granuloma Pyramidal tract syndrome Pyrexia Pyridoxine deficiency Pyrosis Pyuria Quadriplegia Queasy Quincke's edema Radial nerve palsy Radiation injuries Radiation injury Radicular syndrome Radiculopathy Rage Rales Rash Rash erythematous Rash generalised Rash hemorrhagic Rash injection site Rash macular Rash maculo-papular Rash morbilliform Rash papular Rash papulosquamous Rash photosensitivity Rash pruritic Rash pustular Rash scarlatiniform Rash urticarial Rash vesicular Raynaud-like phenomena Raynaud's phenomenon Raynaud's syndrome Reaction anxiety Reactive depression Rebound hypertension Recall phenomenon Rectal bleeding Rectal cancer Rectal carcinoma Rectal discharge Rectal haemorrhage Rectal hemorrhage Rectal mass Rectal pain Rectal tenesmus Rectal ulcer Red blood cell abnormality Red blood cell agglutination Red blood cell disorders Red cell aplasia Red face Reflex loss Reflex tachycardia Reflexes abnormal Reflexes absent Reflexes decreased Reflexes increased Refraction disorder Refractory anaemia Relaxed Renal abscess Renal agenesis Renal and urinary disorders Renal aplasia Renal arteriosclerosis Renal atrophy Renal calculi Renal calculus Renal carcinoma Renal cell cancer Renal cell carcinoma stage unspecified Renal cell carcinomas Renal colic Renal cortical necrosis Renal cyst Renal disease Renal disorder Renal dysgenesis Renal failure Renal failure acute Renal failure aggravated Renal failure and impairment Renal failure chronic Renal failure complications Renal function abnormal Renal function disorder Renal glycosuria Renal haemorrhage Renal hypertension Renal hypertensions Renal impairment Renal injury Renal insufficiency Renal interstitial fibrosis Renal lithiasis Renal neoplasia Renal neoplasm Renal neoplasms Renal pain Renal papillary necrosis Renal papillitis necrotising Renal rickets Renal stone Renal tubular acidosis Renal tubular atrophy Renal tubular disorder Renal tubular dysfunction Renal tubular necrosis Renal vasculitis Repetitive speech Respiration abnormal Respiration depressed Respiration failure Respiratory acidoses Respiratory acidosis Respiratory alkalosis Respiratory arrest Respiratory depression Respiratory disorder Respiratory distress Respiratory distress syndrome adult Respiratory failure Respiratory infection Respiratory insufficiency Respiratory moniliasis Respiratory paralysis Respiratory syncytial viral infections Respiratory tract congestion Respiratory tract infection Respiratory tract infections Respiratory tract irritation Respiratory, thoracic and mediastinal disorders Restless legs Restless legs syndrome Restlessness Retching Retention gastric Retention of urine Retention urinary Retention water Reticulocytosis Reticuloendothelial dysfunction Reticuloendothelial hyperplasia Reticuloendothelial system stimulated Reticuloendotheliosis Retinal artery embolism Retinal artery occlusion Retinal artery spasm Retinal artery thrombosis Retinal damage Retinal degeneration Retinal depigmentation Retinal deposits Retinal detachment Retinal disorder Retinal edema Retinal haemorrhage Retinal hemorrhage Retinal ischaemia Retinal oedema Retinal pigmentation Retinal vascular disorder Retinal vascular thrombosis Retinal vasculitis Retinal vein occlusion Retinal vein thrombosis Retinitis Retinitis pigmentosa Retinopathy Retinopathy of prematurity Retrobulbar neuritis Retrocollis Retroperitoneal bleed Retroperitoneal fibrosis Retroperitoneal haemorrhage Retroperitoneal hemorrhage Retrosternal discomfort Retrosternal pain Retroviral infections Reye's syndrome Rheumatism Rheumatoid arthritis Rheumatoid arthritis aggravated Rheumatoid arthropathies Rhinitis Rhinitis allergic Rhinitis atrophic Rhinitis medicamentous Rhinitis seasonal Rhinorrhea Rhinorrhoea Rhonchi Right heart failure Right upper quadrant pain Right ventricular failure Rigidity Rigidity muscle Rigidity neck Rigidity of limbs Rigors Ringing in ears Risus sardonicus Road traffic accident Rosacea Rouleaux formation Runny nose Ruptured uterus RUQ pain Salicylism Saliva decreased Saliva increased Salivary gland disorder Salivary gland enlargement Salivary gland hypertrophy Salivary gland pain Salivary gland swelling Salivary hypersecretion Salivation Salpingitis Salpingo-oophoritis Salt retention Sarcoidosis Sarcoma Scab Scabbing Scales Scar Scarring Schizoaffective and schizophreniform disorders Schizophrenia Schizophrenia and other psychotic disorders Schizophrenia, disorganised type Schizophrenic reaction Schizophreniform disorder Sciatica Scintillating scotoma Scleral discoloration Scleral discolouration Scleritis Scleroderma Scleroderma-like reaction Scotoma Scrotal edema Scrotal oedema Seasonal allergy Sebaceous cyst Seborrhea Seborrheic dermatitis Seborrhoea Seborrhoeic dermatitis Secondary adrenocortical insufficiency Secondary amenorrhoea Sedation Seizure Seizure cerebral Seizures Sensation of cold Sensation of foreign body Sensation of heat Sensation of heaviness Sensation of pressure Sensation of warmth Sense of oppression Sensorimotor disorder Sensorineural hearing loss Sensory aberrations Sensory deficit Sensory disturbance Sensory hallucinations Sensory loss Sensory neuropathy Sepsis Septicemia Serositis Serum sickness Serum sickness-like reaction Sexual arousal disorders Sexual desire disorders Sexual disorder NOS Sexual dysfunction Sexual problem Shakiness Shaking Shallow breathing Shivering Shivers Shock Shock cardiogenic Shock circulatory Shock hypoglycaemic Shock vascular Shortness of breath Short-term memory loss Shoulder pain SIADH Sialadenitis Sialoadenitis Sialorrhea Sicca syndrome Sick sinus syndrome Sideroblastic anaemia Sideroblastic anemia Simple partial seizures Singultus Sinoatrial block Sinus arrest Sinus arrhythmia Sinus bradycardia Sinus congestion Sinus headache Sinus infection Sinus pain Sinus tachycardia Sinusitis Skeletal muscle paralysis Skeletal pain Skin and subcutaneous tissue disorders Skin atrophy Skin bleeding Skin breakdown Skin burning sensation Skin cancer Skin candida Skin carcinoma Skin coloring Skin depigmentation Skin discoloration Skin discolouration Skin disorder Skin dry Skin dystrophies Skin dystrophy Skin eruption Skin erythema Skin exfoliation Skin fissure Skin fissures Skin fragility Skin granuloma Skin haemorrhage Skin haemorrhages Skin hyperemia Skin hyperpigmentation Skin hypertrophy Skin hypopigmentation Skin infection Skin inflammation Skin irritation Skin lesion Skin melanoma Skin necrosis Skin nodule Skin odour abnormal Skin papilloma Skin peeling Skin pigmentation Skin rash Skin reaction Skin red Skin striae Skin swelling Skin thickening Skin thinning of Skin ulcer Skin ulceration Skin wrinkling Sleep apnea Sleep apnoea syndrome Sleep apnoeas Sleep decreased Sleep difficult Sleep disorder Sleep disorders and disturbances Sleep disturbance Sleep disturbed Sleep excessive Sleep problem Sleep restless Sleep terror Sleep walking Sleepiness Sleeplessness SLE-like symptoms Slight fever Sloughing Sloughing of skin Slowed thinking Sluggishness Slurred speech Small intestinal haemorrhage Small intestinal obstruction Small intestine obstruction Smell alteration Smell loss Sneezing Snoring Sociopathy Sodium depletion Sodium imbalance Sodium retention Soft stools Soft tissue disorder Soft tissue infection Soft tissue sarcomas Solar dermatitis Solar elastosis Somatic delusion Somatoform disorder Somatoform disorder cardiovascular Somatoform disorders Somnambulism Somnolence Sopor Sore mouth Sore throat Sore tongue Spaced out Spasm bronchial Spasm coronary artery Spasm muscle Spasms Spastic bladder Spasticity muscle Speech disorder Speech loss Spermatogenesis arrested Spherocytic anaemia Spinal cord compression Spinal cord paralysis Spinal disorder Spinal epidural haemorrhage Spinal epidural hematoma Spinning sensation Spleen disorder Spleen enlarged Splenic infarction Splenomegaly Spontaneous abortion Spontaneous fracture Spontaneous penile erection Sprain Sputum Sputum increased Squamous cell carcinoma Squamous cell carcinoma of skin Squint Staggering Staggering gait Stammering Staphylococcal bacteraemia Staphylococcal bacteremia Staphylococcal infection Staphylococcal infections Starvation Status asthmaticus Status epilepticus Steatorrhea Steatorrhoea Steatosis hepatic Steroid myopathy Stevens-Johnson syndrome Sticky skin Stiff neck Stiffness Stinging Stinging sensation in eyes Stomach ache Stomach atony Stomach cramps Stomach discomfort Stomach hemorrhage Stomach inflammation Stomach pain Stomach perforation Stomach ulcer Stomach upset Stomachache Stomatitis Stomatitis and ulceration Stomatitis aphthous Stomatitis necrotising Stones common duct Stools abnormal Stools loose Stools watery Strabismus Strain Strangury Strength loss of Streptococcal infection Streptococcal infections Striae Stridor Stridor inspiratory Stroke Stumbling Stupor Stuttering Subarachnoid haemorrhage Subarachnoid hemorrhage Subcutaneous haematoma Subcutaneous hematoma Subcutaneous nodule Subdural haematoma Subdural haemorrhage Subdural hematoma Subdural hemorrhage Subglottic edema Subjective visual disturbances Substance-related disorders Substernal chest pain Substernal pain Suicidal depression Suicidal ideation Suicidal tendency Suicide Suicide attempt Suicide gesture Sulfhemoglobinemia Sulphaemoglobinaemia Sun sensitivity Sunburn Superficial punctate keratitis Superficial punctate keratopathy Superinfection Suppressed lactation Suprapubic pain Supraventricular arrhythmias Supraventricular extrasystoles Supraventricular tachycardia Suspiciousness Sustained ventricular tachycardia Swallowing difficult Swallowing disorder Swallowing impaired Sweat discolouration Sweating Sweating decreased Sweating increased Swelling Swelling face Swelling of face Swelling of fingers Swelling of knees Swelling of lips Swollen ankles Swollen eyes Swollen glands Swollen joints Swollen lips Swollen tongue Syncope Syncope vasovagal Syndrome adult respiratory distress Syndrome anticholinergic Syndrome cholinergic Syndrome extrapyramidal Syndrome Gilles de la Tourette Syndrome hyperkinetic Syndrome nephrotic Syndrome peptic ulcer Syndrome restless legs Syndrome Stevens-Johnson Synovial cyst Synovial disorders Synovitis Systemic anaphylaxis Systemic lupus erythematosus Systemic mycosis Tachyarrhythmia Tachycardia Tachycardia atrial Tachycardia nodal Tachycardia paroxysmal Tachycardia paroxysmal atrial Tachycardia sinus Tachycardia supraventricular Tachycardia ventricular Tachypnea Tachypnoea Talipes Talkativeness Tamponade cardiac Tardive dyskinesia Tarry stools Taste abnormality Taste alteration Taste bitter Taste disorders Taste disturbance Taste loss Taste perversion Taste sweet T-cell lymphoma Tear disorder Tearfulness Tearing eyes Telangiectasia Telogen effluvium Temperature intolerance Temporal headache Temporal lobe epilepsy Tenderness Tenderness breast Tendinitis Tendon calcification Tendon disorder Tendon disorders Tendon rupture Tendonitis Tenosynovitis Tenosynovitis stenosans Tenseness Tension Tension headache Testicular atrophy Testicular disorder Testicular dysfunction Testicular pain Tetany Thermal burn Thermal burns Thinking abnormal Thinking disturbances Thinking reduced Third degree AV block Thirst Thought blocking Throat constriction Throat dry Throat infection Throat irritation Throat pain Throat sore Throat tightness Thromboangiitis obliterans Thrombocythaemia Thrombocythemia Thrombocytopenia Thrombocytopenias Thrombocytosis Thromboembolic event Thromboembolism Thrombopenia Thrombophlebitis Thrombophlebitis deep Thrombophlebitis superficial Thrombosis Thrombosis arterial Thrombosis carotid Thrombosis cerebral Thrombosis coronary Thrombosis mesenteric artery Thrombosis mesenteric vessel Thrombosis pulmonary Thrombosis venous Thrombotic microangiopathy Thrombotic thrombocytopenic purpura Thyroid adenoma Thyroid disorder Thyroid enlarged Thyroid gland disorders Thyroid neoplasia Thyroid neoplasm Thyroid neoplasms Thyroid nodule Thyroid storm Thyroiditis Thyrotoxic crisis TIA Tibial artery thrombosis Tic Tic disorders Tics Tight chest Tightness in chest Tinea Tinea cruris Tinea infection Tinea infections Tinea pedis Tingling Tingling skin Tinnitus Tiredness Tongue black hairy Tongue coated Tongue conditions Tongue discoloration Tongue discolouration Tongue disorder Tongue edema Tongue geographic Tongue oedema Tongue pain Tongue paralysis Tongue sore Tongue tie Tongue ulceration Tongue white Tonic clonic movements Tonic/ clonic convulsions Tonsillitis Tooth abscess Tooth caries Tooth discoloration Tooth discolouration Tooth disorder Tooth hypoplasia Tooth pain Toothache Torpor Torsade de pointes Torsades de pointes Torticollis Total fluid volume increased Touch sensitivity increased Tourette's disorder Tourette's syndrome Toxic confusional state Toxic epidermal necrolysis Toxic erythema Toxic induced encephalopathy Toxic myopathy Toxic nephropathy Toxic skin eruption Toxicity renal Toxoplasma infections Toxoplasmosis Tracheitis Tracheobronchitis Transient blindness Transient ischaemic attack Transient ischemic attacks Trauma Traumatic arthritis Traumatic arthropathy Trembling Tremor Tremor muscle Tremor of hands Tremor perioral Tremulousness Trigeminal disorders Trigeminal neuralgia Trigeminy Trismus Trophic disorders True precocious puberty Tuberculosis Tuberculous infections Tubular vision Tumor flare Tumor lysis syndrome Tumor pain Tumour flare Tumour lysis syndrome Tunnel vision Twitch skeletal muscle Twitches Twitching Tympanic membrane perforation Tympanites Type I hypersensitivity Type III immune complex mediated reaction Type IV hyperlipidaemia Type IV hypersensitivity reaction Ulcer Ulcer bleeding duodenal Ulcer colon Ulcer corneal Ulcer duodenal Ulcer esophageal Ulcer gastric Ulcer gastroduodenal Ulcer gastrointestinal Ulcer peptic Ulcer skin Ulcer stomach Ulcer stress Ulceration of mouth Ulceration tongue Ulcerative colitis Ulcerative enterocolitis Ulcerative keratitis Ulcerative stomatitis Ulcus ventriculi Unconsciousness Unstable angina Unsteadiness Unsteady gait Upper abdominal pain Upper gastrointestinal haemorrhage Upper gastrointestinal hemorrhage Upper gastrointestinal symptoms Upper limb fracture Upper limb fractures Upper limb fractures and dislocations Upper motor neurone lesion Upper respiratory infection Upper respiratory tract infection Upper respiratory tract infections Upset stomach Uraemia Urate nephropathy Uremia Ureter obstruction Ureteral calculus Ureteral pain Ureteric injury Ureteric obstruction Urethral calculus Urethral disorder Urethral pain Urethral spasm Urethritis Uric acid nephropathy Uricaciduria Urinary abnormalities Urinary bladder carcinoma Urinary bladder obstruction Urinary frequency Urinary hesitancy Urinary hesitation Urinary incontinence Urinary infection Urinary retention Urinary tract bleeding Urinary tract disorder Urinary tract infection Urinary tract infection neonatal Urinary tract infections Urinary tract malformation Urinary tract obstruction Urinary tract pain Urinary tract stone Urinary urgency Urination difficulty Urination pain Urine abnormality Urine discoloration Urine incontinence Urogenital malformation Urolithiases Urolithiasis Uropathy Urticaria Urticaria acute Urticaria physical Urticaria thermal Urticarial rash Urticarias Uterine atony Uterine bleeding Uterine disorder Uterine fibroid Uterine fibromyoma Uterine haemorrhage Uterine hemorrhage Uterine hypertonus Uterine hypotonus Uterine infection Uterine leiomyoma Uterine neoplasm Uterine neoplasms Uterine perforation Uterine rupture Uterine spasm Uterovaginal prolapse UTI Uveitis Vagal reaction Vaginal bleeding Vaginal candidiasis Vaginal discharge Vaginal dryness Vaginal haemorrhage Vaginal hemorrhage Vaginal infection Vaginal inflammation Vaginal irritation Vaginal itching Vaginal moniliasis Vaginal ulceration Vaginitis Vaginitis bacterial Vaginitis gardnerella Varices oesophageal Varicose ulceration Varicose vein Varicose veins Varicosity Vascular collapse Vascular disorder Vascular disorders Vascular headache Vascular neoplasm Vascular neoplasms Vascular pain Vascular purpura Vasculitides Vasculitis Vasculitis allergic Vasculitis diffuse Vasculitis necrotising Vasculitis necrotizing Vasculitis retinal Vasoconstriction Vasoconstriction peripheral Vasodilatation Vasomotor collapse Vasospasm Vasospasm cerebral Vasovagal attack Vasovagal reaction Vasovagal symptoms Vein distended Vena cava thrombosis Venoocclusive disease Venoocclusive liver disease Venospasm Venous insufficiency Venous thrombophlebitis Venous thrombosis Ventricular arrhythmia Ventricular arrhythmias and cardiac arrest Ventricular asystole Ventricular asystolia Ventricular bigeminy Ventricular ectopic beats Ventricular ectopics Ventricular extrasystoles Ventricular fibrillation Ventricular septal defect Ventricular tachycardia Verbosity Verruca Vertebral fracture Vertigo Vertigo CNS origin Vesicular eruption Vesicular rash Vesiculo-bullous eruption Vesiculobullous rash Vesiculopustular rash Vestibular abnormalities Vestibular disorder Vestibular nerve damage Vestibular neuronitis Violent Violent behavior Viral diarrhoea Viral gastroenteritis Viral infection Viral syndrome Viral upper respiratory tract infection Viral upper respiratory tract infections Viral warts Virilisation Virilism Virilization Virus hepatitis Vision abnormal Vision blurred Vision decreased Vision dim Vision disorders Vision double Vision loss Visual acuity decreased Visual acuity reduced Visual discomfort Visual disturbance Visual disturbances Visual field constriction Visual field defect Visual field disorders Visual hallucinations Visual impairment Visual phenomena Vitamin B complex deficiency Vitamin B12 deficiency Vitamin B6 deficiency Vitamin K deficiency VIth nerve paralysis Vitiligo Vitreous detachment Vitreous disorder Vitreous floaters Vitreous haemorrhage Vitreous hemorrhage Vitreous opacities Vitreous opacity Vivid dreams Vocal cord edema Vocal cord paralysis Vocal cord thickening Voice alteration Voice disturbance Vomiting Vomiting blood Vomiting neonatal Vulval itching Vulval pruritus Vulvovaginal discomfort Vulvovaginal disorder Vulvovaginal dryness Vulvovaginal mycotic infection Vulvovaginal signs and symptoms Vulvovaginitis Wakefulness Walking difficulty Wandering Wasting Wasting generalized Water intoxication Water retention Watery diarrhea Watery diarrhoea Waxy flexibility Weakness Weakness generalized Weakness muscle Weakness of limbs Weakness postural Weariness Wegener's granulomatosis Welts Wenckebach phenomenon Wernicke-Korsakoff syndrome Wheals Wheeze Wheezing Wheezing inspiratory White blood cell disorders Withdrawal bleed Withdrawal bleeding Withdrawal convulsions Withdrawal headache Withdrawal reaction Withdrawal seizures Withdrawal syndrome Wooziness Worry Wound Wound haemorrhage Wound healing delayed Wound hemorrhage Wrist drop Wrist fracture Wryneck Xanthelasma Xanthoma Xanthopsia Xeroderma Xerophthalmia Xerosis Xerostomia Yawn Yawning Yeast infection Yellow skin deficiency Zinc disorders Zollinger-Ellison syndrome