18/02/2019 Suggested additions: 1 Anatomical Tests General IVDs for care facilities with laboratories and trained anatomical pathologists

Diagnostic test Test purpose Assay format Specimen type

Anatomical Pathology Macroscopic assessment Macroscopic assessment of diseased and Macroscopic assessment of Surgical resection selection of areas for microscopic examination surgically removed tissue

Histopathology Microscopic assessment of tissue for , of tissue sections Surgical resection neoplasia, inflammatory and degenerative mounted on slides and stained most disorders commonly with and Biopsy eosin in the first instance, then treated with a variety of special stains, selected case-by-case, to Core biopsy identify and other abnormal features Cell block

Cytology () Microscopic assessment of cells for infection, Microscopy of stained cells on slides Cervical specimen for Pap smear neoplasia, inflammatory and degenerative disorders Body fluids: CSF, urine, pleural and peritoneal fluids etc. Fine needle aspirate (FNA) of , , other tissues Bone marrow aspirate

Sputum, bronchial brushings, samples

Immunohistochemistry Microscopic assessment of cells for specific Microscopy of tissue sections Surgical resection markers to assess infection, neoplasia, mounted on slides and stained with inflammatory and degenerative disorders to specific markers. Biopsy Refer to -Specific Tests for Core biopsy individual assays. Cell block

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