US 20150.038552A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0038552 A1 Rothenberg et al. (43) Pub. Date: Feb. 5, 2015 (54) ESOPHAGEAL MICRORNA EXPRESSION (52) U.S. Cl. PROFILES INEOSINOPHILIC ESOPHAGITIS CPC ........ CI2O I/6883 (2013.01); C12O 2600/178 (2013.01) (71) Applicant: CHILDRENS HOSPITAL USPC ............ 514/44A: 514/44 R: 514/169; 506/9: MEDICAL CENTER, Cincinnati, OH 506/16: 435/6.12 (US) (72) Inventors: Marc E. Rothenberg, Cincinnati, OH (57) ABSTRACT (US); Thomas Xuefeng Lu, Cincinnati, OH (US) Methods and compositions disclosed herein generally relate to methods of treating eosinophilic esophagitis (EE) and eosi (21) Appl. No.: 14/380,672 nophilic disorders by providing or enhancing a diagnosis of EE and eosinophilic disorders. In particular, the invention (22) PCT Filed: Feb. 22, 2013 relates to obtaining a sample from a patient, then quantifying from the sample an amount of one or more microRNAs (miR (86). PCT No.: PCT/US2013/027503 NAs) associated with EE, wherein an altered level of the S371 (c)(1) miRNA correlates with a positive diagnosis of EE. An EE (2) Date: s Aug. 22, 2014 diagnosis can then be provided or enhanced, based upon the 9 quantifying step, and an appropriate treatment can be admin Related U.S. Application Data istered to the patient. The invention further relates to diag (60) Provisional application No. 61/602,897, filed on Feb. nostic kits, tests, and/or arrays that can be used to quantify the 24, 2012. one or more miRNAs associated with EE, as well as treat s ments developed to up-regulate or down-regulate one or more Publication Classification miRNAs and/or their downstream pathways relevant to EE or asthma. The invention further relates to the use of IGF1 and (51) Int. Cl. IGF1R inhibitors for the treatment of EE and eosinophilic CI2O I/68 (2006.01) disorders. 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