A Small Dose of Toxicology 3rd Edition Free e-book PDF and Power- point slides for each of 29 Chapters or Download whole book in one file See: www.asmalldoseoftoxicology.org A Small Dose of Toxicology Small Dose of Toxicology FREE www.asmalldoseoftoxicology.org English, Spanish, Arabic, German, Chinese A Small Dose of Toxicology A Small Dose of Toxicology 3rd Edition Chapter 1 - Toxicology and You Chapter 16 - Metals Chapter 2 - Principles of Toxicology Chapter 17 – Solvents and Vapors Chapter 3 – Risk Assessment and Risk Chapter 18 – Radiation Management Chapter 19 – Persistent Environmental Chapter 4 – Ethical, Legal and Social Contaminants Implications Chapter 20 – Endocrine Disruptions Chapter 5 – A Small History of Toxicology Chapter 21 – Nanoparticles Chapter 6 – Connecting the Dots of Chapter 22 – Animal and Plant Toxins Science, History, and Ethics Chapter 23 – The Nervous System Chapter 7 - Alcohol Chapter 24 – Cancer and Genetic Chapter 8 - Caffeine Toxicology Chapter 9 - Nicotine Chapter 25 – Pregnancy and Chapter 10 – Marijuana (THC, CBD) Developmental Toxicology Chapter 11 - Pesticides Chapter 26 – Air Pollution Chapter 12 – Lead Chapter 27 – Water Pollution Chapter 13 - Mercury Chapter 28 – Soil Pollution Chapter 14 – Arsenic Chapter 29 – Toxics in the Home Chapter 15 – Fluoride A Small Dose of Toxicology www.asmalldoseoftoxicology.org Why A Small Dose of Toxicology A Small Dose of Toxicology The Health Effects of Common Chemicals (3rd edition) • Down load PDF files of individual chapters or entire book • Explore principles of toxicology – dose / response • Learn why children are more susceptible to toxic exposures than adults • Learn why coffee & cola companies make so much money from caffeine • Explore the health effects of common & environmental chemicals • Learn about the effects of nicotine, alcohol, lead, mercury, pesticides …. • Learn about toxic chemicals around the home & workplace • Learn about risk assessment & the precautionary principle A Small Dose of Toxicology www.asmalldoseoftoxicology.org A Small Dose of Toxicology 3rd Edition Released as a FREE E-book November 14, 2020 Seattle, WA -- A Small Dose of Toxicology: The Health Effects of Common Chemicals, 3rd Edition, by Steven G. Gilbert, PhD, DABT, was released as a free e-book November 14, 2020. This new Edition added several new chapters and updated all chapters. The good news is that you can download each chapter as a PDF file and PowerPoint files can be used for teaching of that particular chapter material. It’s free, try it out at www.asmalldoseoftoxicology.org. A Small Dose of Toxicology is an introductory toxicology textbook that examines the health effects of common chemical agents and places toxicology within the framework of everyday life. Agents covered include not only obvious candidates such as lead, mercury, and solvents, but familiar compounds such as caffeine, alcohol, nicotine, cannabis, and fluoride. Additional chapters cover basic toxicology, targets of toxic agents, risk assessment, history, and ethics. This revised and expanded Third edition is available only as a free e-book and contains numerous hyperlinks to articles and PowerPoint presentations on the “A Small Dose of Toxicology” web site at (www.asmalldoseoftoxicology.org). Links to references and other informational websites are also included. Free copies can be downloaded as individual chapters or as a full book in PDF format. A Small Dose of Toxicology is designed for students of all ages who are interested in learning about how common everyday chemicals affect their health. Teachers and students can freely access PowerPoint slides and links to current references for each chapter from the web site. The book strives to engage students and readers by placing scientific information in the context of history, society, and culture. In keeping with desire to share its efforts to foster a more peaceful, healthy, and sustainable world, A Small Dose of Toxicology is offered for free as an ebook. Donations are encouraged to support the work of INND (The Institute of Neurotoxicology and Neurological Disorders). INND is a 501(c)(3) corporation so all donations are tax deductible. Contact: Steven G. Gilbert, 206-605-6536, [email protected]. Toxicology and You - Revised: ED3 – 10/20/19 Toxicology and You Or An Introduction to A Small Dose of Toxicology Chapter 1 of Third Edition of A Small Dose of Toxicology - The Health Effects of Common Chemicals By Steven G. Gilbert, PhD, DABT Institute of Neurotoxicology & Neurological Disorders (INND) Seattle, WA 98105 E-mail: [email protected] Supporting web site web: www.asmalldoseoftoxicology.org FREE www.asmalldoseoftoxicology.org English, Spanish, Arabic, German, Chinese File: Chapter 1 Tox and You.ED3.10.20.20.docx – Date: 10/31/2020 – Page 1 of 18 Toxicology and You Toxicology is about the chemicals that adversely affect the health and well-being of life on the earth we inhabit. Chemicals are not all bad, after all we are made up of chemicals, indeed life is made up of a vast array of chemicals working together in an intricate synchrony. Chemicals are life and we depend on them to live. Unfortunately, some naturally occurring or human created chemicals can upset the balance that we depend on to lead a healthy life. This is toxicology, the understanding of how a small distortion in the chemical balance can adversely affect health of even result in death. Toxicology originally developed as the study of poisons and is now more formally described as the study of the adverse effects of chemical or physical agents on living organisms. During our lives, most of us begin to develop an intuitive sense of toxicology that guides many of our personal day-to-day decisions. This process can start first thing in the morning over a cup of coffee or tea or a can of cola. These common beverages contain caffeine, the most widely consumed stimulant in the world. Most consumers of caffeine are well aware of the benefits of this drug as well as the consequences of consuming too much. Through trial and error we have learned how to moderate our consumption of caffeine to avoid any undesirable effects. In regulating our consumption of caffeine we are applying the most basic principle of toxicology: dose / response. We apply this principle as we judge how much and what to eat or drink, or how much suntan lotion we should use before going to the beach. As we shall see in a future chapter, caffeine provides an excellent example of how we apply knowingly or unknowingly the principles of toxicology. Understanding how caffeine interacts with the body can even explain why the coffee and soda companies make so much money from this amazing drug. Looking at the world through the lens of toxicology provides a very interesting perspective on current, historical, and personal events. The purpose of A Small Dose of Toxicology is to build upon our intuitive understanding of toxicology into knowledgeable and comfortable application of the principles of toxicology. Placing some form and structure around what we already intuitively know about toxicology will allow more critical analysis of not only our immediate environment but many of the current events that shape our local and global society. Toxicological considerations shape directly or indirectly many decisions about our home, play, school, or work environments. As citizens in a democratic society, we must be able to meaningfully engage decision makers in industry, government, and the news media to influence the development of our local environment as well as society. This book is not about the thousands of commercial chemicals that are in use, but rather about the File: Chapter 1 Tox and You.ED3.10.20.20.docx – Date: 10/31/2020 – Page 2 of 18 principles that guide decisions about their use and distribution. A little knowledge about toxicology will allow us to better judge the potential effect on our lives, ask insightful questions, and ultimately influence the decision makers. Historically, toxicology was most often concerned with how much of a substance it took to kill you. Literature has some splendid examples of the awareness of naturally occurring poisons. The ancient Greeks were very knowledgeable about the properties of the plant, Hemlock, part of the parsley family, even though they did not know what specific chemical in it caused death. In 399 BC Socrates was condemned to die by Hemlock after being charged with religious heresy and corrupting the morals of local youth. We now know that the active chemical is the alkaloid coniine, which when ingested causes paralysis, convulsions, and potentially death. More modern examples of the knowledge of poisons can be seen in the following from a well-known playwright, Shakespeare: From Romeo and Juliet - act 5 Come bitter pilot, now at once run on The dashing rocks thy seasick weary bark! Here’s to my love! O true apothecary! Thy drugs are quick. Thus with a kiss I die. Shakespeare ? Historical events can also be interpreted from the perspective of toxicology. For example, Great Britain acquired Hong Kong during the Opium War of 1839-42, which was really about the toxic and additive properties of opium. Medical uses of opium included the treatment of diseases such as dysentery and cholera. Users soon found that smoking a mixture of tobacco and opium increased the absorption of opium, resulting in a more rapid onset of its effects. The Chinese government was trying to curb the smoking of opium because of its debilitating effects, which was at odds with the British desire to increase the opium trade to make money. Opium was not made illegal in the United States until 1924. The popularity of drug use continues and governments are engaged in a variety of efforts to curb their use including “drug wars” with neighboring countries. Knowledge about the physiological and toxicological properties of drugs (legal or illegal) is important in developing sound public policy.