Douglas ® Product Data Laboratories P DMG-125 Pure Dimethylglycine in Sublingual Form DESCRIPTION SUGGESTED USE Dimethylglycine tablets, provided by Douglas Laboratories, One tablet, one to three times daily, or as directed by contain pure N,N-dimethylglycine (DMG). Each tablet is healthcare professional. Tablets may be placed under the foil-wrapped individually to preserve freshness. Tablets are tongue for sublingual administration or swallowed whole. formulated to dissolve rapidly, and are free of any excipients or other additives. SIDE EFFECTS No adverse side effects have been reported. FUNCTIONS DMG is a natural, methylated derivative of the amino acid STORAGE glycine. It occurs in low levels in both plants and animals, Store in a cool, dry place, away from direct light. Keep out primarily as an intermediary metabolite. of reach of children. DMG is indirectly involved in a wide array of metabolic pathways. As a significant donor of one carbon methyl REFERENCES groups, it enhances transmethylation processes which are Bishop PA, Smith JF, Young B. Effects of N,N-dimethylglycine on essential for proper functioning of vitamins, hormones, physiological response and performance in trained runners. J Sports Med Phys Fitness 1987;27:53-56. neurotransmitters, enzymes, nucleic acids, and antibodies. DMG further enhances trasmethylation by promoting the Gascon G, Patterson B, Yearwood K, Slotnick H. N,N dimethylglycine and epilepsy. Epilepsia 1989;30:90-93. synthesis of methionine from homocysteine. Methionine is Graber CD, Goust JM, Glassman AD, Kendall R, Loadholt CB. then converted to S-Adenosylmethionine (SAM), the active Immunomodulating properties of dimethylglycine in humans. J Infect Dis transmethylating agent in the body. 1981;143:101-105. DMG also generates glycine, which may be converted to Reap EA, Lawson JW. Stimulation of the immune response by creatine, a high energy phosphate molecule used by muscle dimethylglycine, a nontoxic metabolite. J Lab Clin Med 1990;115:481-486. tissue and the central nervous system. The antioxidant Rose RJ, Schlierf HA, Knight PK, Plummer C, Davis M, Ray SP. Effects of properties of DMG mean it can complex free radical N,N-dimethylglycine on cardiorespiratory function and lactate production molecules which may cause cell damage if left unchecked. in thoroughbred horses performing incremental treadmill exercise. Vet Rec 1989;125:268-271. INDICATIONS Tonda ME, Hart LL. N,N dimethylglycine and L-carnitine as performance Dimethylglycine tablets may be a useful nutritional adjunct enhancers in athletes. Ann Pharmacother 1992;26:935-937. for individuals who wish to supplement their diets with Weiss RC. Immunologic responses in healthy random-source cats fed N,N- dimethylglycine-supplemented diets. Am J Vet Res 1992;53:829-833. significant amounts of DMG. FORMULA (#7412) Each foil-wrapped tablet contains: N,N-Dimethylglycine (DMG) ............................. 125 mg These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Douglas Laboratories 600 Boyce Road Pittsburgh, PA 15205 800-245-4440 © 2007 Douglas Laboratories. All Rights Reserved .