University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Mechanical & Materials Engineering Faculty Mechanical & Materials Engineering, Publications Department of 11-13-2018 SYSTEM AND METHODS FOR VENTILATION THROUGH A BODY CAVITY Mark A. Borden Benjamin S. Terry Follow this and additional works at: https://digitalcommons.unl.edu/mechengfacpub Part of the Mechanics of Materials Commons, Nanoscience and Nanotechnology Commons, Other Engineering Science and Materials Commons, and the Other Mechanical Engineering Commons This Article is brought to you for free and open access by the Mechanical & Materials Engineering, Department of at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Mechanical & Materials Engineering Faculty Publications by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. US010124126B2 (12 ) United States Patent ( 10 ) Patent No. : US 10 , 124 , 126 B2 Borden et al . ( 45 ) Date of Patent: Nov . 13 , 2018 ( 54 ) SYSTEM AND METHODS FOR ( 58) Field of Classification Search VENTILATION THROUGH A BODY CAVITY CPC . A61M 13 /003 ; A61M 13 / 006 ; A61M 16 /00 ; (71 ) Applicants : The Regents of the University of A61M 16 /04 ; A61M 16 / 10 ; Colorado , a Body Corporate , Denver, (Continued ) CO (US ) ; Board of Regents of the University of Nebraska , Lincoln , NE (56 ) References Cited (US ) U . S . PATENT DOCUMENTS (72 ) Inventors : Mark A . Borden , Boulder , CO (US ) ; Benjamin S . Terry , Lincoln , NE (US ) 2004/ 0013662 A1 * 1/ 2004 Porter .. .. A61K 41/ 0028 424 /94 .61 ( 73 ) Assignees : THE REGENTS OF THE 2004/ 0097867 A1 * 5 / 2004 Fraser .. .. .. C12N 5 /0667 UNIVERSITY OF COLORADO , A 604 / 27 BODY CORPORATE , Denver, CO ( Continued ) (US ) ; BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , FOREIGN PATENT DOCUMENTS Lincoln , NE (US ) WO W NOO 2011025893 AlA1 * 3 / 2011 .. .. .. A61K 49 / 223 ( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 OTHER PUBLICATIONS U . S . C . 154 ( b ) by 143 days . Klein , J ., et al. , Transperitoneal oxygenation with fluorocarbons. (21 ) Appl . No. : 14 /256 ,488 Anesthesia & Analgesia , 1986 . 65 ( 7 ) : p . 734 - 738 . ( 22 ) Filed : Apr. 18 , 2014 (Continued ) (65 ) Prior Publication Data Primary Examiner - Kevin C Sirmons US 2014 / 0316331 A1 Oct . 23 , 2014 Assistant Examiner — Tiffany Legette - Thompson Related U .S . Application Data (74 ) Attorney , Agent, or Firm - Brainspark Associates , (60 ) Provisional application No . 61/ 813 ,626 , filed on Apr. LLC 18 , 2013 ABSTRACT (51 ) Int. Cl. (57 ) A61M 37 / 00 ( 2006 .01 ) A system and methods for the delivery of oxygen through a A61M 13 / 00 ( 2006 . 01 ) body cavity of a subject using oxygen microbubbles . A61M 1 /32 ( 2006 .01 ) Through circulation of oxygen microbubbles through the A61M 1 / 28 ( 2006 . 01 ) body cavity , oxygen and carbon dioxide exchange may A61M 16 / 04 ( 2006 .01 ) occur. Overall improvement in extending survival rate time ( 52 ) U . S . CI. during emergency situations caused by pulmonary or similar CPC . .. .. .. .. .. A61M 13 / 003 ( 2013 .01 ) ; A61M 1 /28 oxygen - intake restricting injury and / or failure may be ( 2013 . 01 ) ; A61M 1/ 32 ( 2013 .01 ) ; A61M 16 /04 achieved through use of the invented system and methods . ( 2013 .01 ) ; ( Continued ) 8 Claims, 8 Drawing Sheets Purge 214 202 Vent 216 Oxygen 206 204 Lipid Solution Gas 208 Cooling Cooling 210 Microbubbles and Foam Foam 218 207 212 219 222 Collection 220 ? Syringe 200 US 10 , 124 , 126 B2 Page 2 (52 ) U . S . CI. 2005/ 0260189 A1 * 11/ 2005 Klibanov .. .. .. A61K 9 / 127 CPC . .. A61M 2202 /0208 ( 2013 .01 ) ; A61M 424 / 130 . 1 2205 / 3344 (2013 .01 ) ; A61M 2205 / 3653 2009 /0191244 A1 * 7 / 2009 Kheir . .. A61K 47/ 48869 ( 2013 .01 ) ; A61M 2205/ 502 ( 2013 .01 ) ; A61M 424 /400 2230 / 202 ( 2013 .01 ) ; A61M 2230 / 205 2010 /0083968 A1 * 4 /2010 Wondka . .. .. A61M 16 / 12 128 /204 .23 ( 2013 .01 ) ; A61M 2230 / 50 ( 2013 .01 ) 2010 /0204765 A1* 8 /2010 Hall .. A61F 7 / 12 ( 58 ) Field of Classification Search 607 / 105 CPC . .. .. .. .. A61M 16 /0012 ; A61M 16 / 0402 ; A61M 2012/ 0175305 Al * 7 / 2012 Borden .. .. A61K 49/ 223 16 / 005 ; A61M 1 /32 , A61M 2230 / 205 ; 210 /644 A61M 2230 / 202 ; A61M 2205 /3344 ; 2014 /0328767 A1* 11/ 2014 Wang .. A61K 41/ 0028 A61M 2205 /502 ; A61M 16 / 1005 ; A61M 424 / 9 . 52 16 / 14 ; A61M 16 / 0054 ; A61M 13 / 00 ; A61M 1 /003 ; A61K 47 /6925 USPC .. 604 / 26 , 27 ; 128 / 204 . 18 , 204 . 14 , 204 , 15 , OTHER PUBLICATIONS 128 /204 . 16 Matsutani, N ., et al. , The Peritoneum as a Novel Oxygenation See application file for complete search history . Organ : Revitalization of Intraperitoneal Oxygenation . Shock , 2008 . 30 ( 3 ) : p . 250 -253 . ( 56 ) References Cited Zhang, J ., et al ., Effect of oxygenation of transperitoneal ventilation on the death time after asphyxiation in rabbits . Minerva anestesiologica , U . S . PATENT DOCUMENTS 2010 . 76 ( 11 ) : p . 913 . 2005/ 0008806 A1* 1 / 2005 Schewe .. .. A61M 25 /0009 428 /36 . 9 * cited by examiner atent Nov . 13 , 2018 Sheet 1 of 8 US 10 , 124 ,126 B2 wwwwwwwwwww . .. Atosww Monitoring Device 114 116 wwwww Computer Device . ! Subject 102 Cavity 104 S Sensors 112 FIG.1 . Pump 108 Supply Device 106 Device Waste Receptacle 110 100 U . S . Patent Nov. 13, 2018 Sheet 2 of 8 US 10 , 124 ,126 B2 222 214 216Vent 218Foam 219 Syringe Purge Collection ? Oxygen206 210Cooling 220220 MicrobubblesandFoam FIG.2 Gas NY 212 noorte dan 202 201207 Lipid —Cooling 2 200 204 208 U . S . Patent Nov. 13, 2018 Sheet 3 of 8 US 10 , 124 ,126 B2 304 312 322 OMB Supply 320 ??? ???? WithWastevalve Control pulseox, 306 HD pump lished Are 314 controller com. Art 77 316 perwowww ? Pulseox . FIG.3 Whis WAVOVAMOS * .walay mit van * Scavengetube Tailveincatheter 318 302" 310 .2 300 atent Nov . 13 , 2018 Sheet 4 of 8 US 10 , 124 ,126 B2 4301 428 LabVIEW|432 www sensor Surgivet he wwwwwwwwwwwww Pressure HealthSensors426 |426 *** . EndotrachealTube3 wagens 402 SA ASTRO 414 406 404 FIG.4 40°C C Fluidwarmer 2 both D . 410 408OMB 422 supplyline 412Pump Solenoid . inletOz418 424 www Waste 420Ovent VivWww tank 416 400 atent Nov . 13 , 2018 Sheet 5 of 8 US 10 , 124 ,126 B2 . Communication Interface 516 TADA Display(1/0) Memory510 HardDisk Unit512 StorageUnit514 Secondary FIG.5 Interface 502 Communication Infrastructure 504 Removable Main Memory 508 WMO 500 Processor 506 U .S . Patentatent Nov . 13 , 2018 Sheet 6 of 8 US 10 , 124 ,126 B2 Enter mass of rabbit Solenoid engaged Start measuring (AP and fluid • Closes scavenge line infusion for 4 minutes at 80 . Abdomen fills mL /min Monitor IAP Infuse at 12 .56 mL/ ( min *kg ) Wait one minute Disengage . IAP < 2 mmHg . Solenoid manually IAP < 4 mmHg Check for scavenging of fluid Solenoid disengaged Opens scavenge line • Abdomen empties No Yes Seal rabbit 's ET tube FIG . 6 atent Nov . 13 , 2018 Sheet 7 of 8 US 10 , 124 ,126 B2 120 1 " Saline -OMBS 90 + 60 Minutes FIG.7 30 www in . 2 . survival Percent.. U . S . Patent Nov. 13, 2018 Sheet 8 of 8 | US 10, 124, 126 B2 = ???????? … … … … … … … … … … … … … … … … … … … … … … … … … … … … … 18 16 .86?????5??F12333PAPE81 ? -SalineBolus mensenmeOMBBolus rrentraventerman 14 -SalinePerfusion .OMBPerfusion Hu in-1EYESta184PageAFABEBE4E41 ??·???????? ??????? 12 1?????????????? ?? Time(min) … 810 FIG.8 : ????? ? :?????????? , ??????????? … 246 ) % ( Survival US 10 , 124 , 126 B2 SYSTEM AND METHODS FOR associated with significant complications, sometimes addi VENTILATION THROUGH A BODY CAVITY tional therapies are required such as the use of anticoagu lants ( heparin is standard ) . However , anticoagulants are CROSS REFERENCE TO RELATED often administered to the patient leading to additional APPLICATIONS 5 adverse side effects . Additionally , ECMO is expensive and complex to operate , limiting its accessibility for emergency This application claims the benefit of U . S . provisional care . applications 61 /813 ,626 filed Apr . 18 , 2013 , which is incor Because of the high mortality rate , methods of bypassing porated by reference herein in its entirety . the lungs and delivering oxygen directly to the body have been explored for many years . Research has focused on FEDERAL FUNDING peritoneal oxygenation as a method of extrapulmonary res piration . The exchange of oxygen and carbon dioxide occurs This invention was made with government support under through the large surface area of the membrane that lines the grant number CBET1059726 awarded by the National Sci abdominal cavity , the peritoneum . ence Foundation . The government has certain rights in the 15 Previous methods include in situ extrapulmonary venti invention . lation (EV ) . Success in oxygenating blood in situ has been achieved by circulating fluorocarbons, blood , and liposome FIELD OF THE INVENTION encapsulated hemoglobin ( a synthetic oxygen carrier ) The invention relates generally to the delivery of oxygen 20 through the intraperitoneal ( IP ) space , or cavity . Additional to a subject. More particularly, the invention relates to the previous methods include the study of carriers for the delivery of oxygen through a body cavity of a subject using delivery of oxygen . Carriers have included blood , perfluo oxygen microbubbles . rocarbon (PFC ) , and synthetic hemoglobin carriers , for example TRM -645 , which are effective . In contrast , pure BACKGROUND OF THE INVENTION 25 oxygen gas has been shown not to be an effective carrier. None of the effective carriers , however , are both safe