ISSN: 2531-0151 IBJ PlusVolume 1, Special Issue 2, May 2018 1st PhD Research Symposium in Health Sciences and Bio- medicine. School of Medicine. Doctoral Programs in Health Sciences and Biomedicine. Madrid, May 18th 2018 1st PhD Research Symposium in Health Sciences and Biomedicine Abstract Book School of Medicine Universidad Autónoma de Madrid 18 May 2018 www.ibjournals.com Welcome and presentation www.ibjournals.com On behalf of the organizing committee, we welcome you to the first 1st PhD Research Symposium in Health Sciences and Biomedicine organized by the Faculty of Medicine of Universidad Autónoma de Madrid (UAM), Madrid. The Symposium will take place at the Medicine Campus UAM on May 18th, 2018. Doctoral Programs in Health Sciences and Biomedicine (Medicine and Surgery, Epidemiology and Public Health, Molecular Biosciences, Microbiology, Neuroscience, Pharmacology and Physiology, Clinical and Health Psychology) with merging common interests in this area will celebrate a one-day Symposium to strengthen their commitment to broaden collaborative strategies in education and research. The meeting will be a stimulating gathering of advanced graduate students, where those at least in their second academic tutelage, are invited to present a scientific communication including the main hypothesis, objectives and results of their Doctoral Theses. PhD students in their first year are welcome for registration and meeting attendance. This innovative event will be an optimal forum to showcase their research and foster communication and potential collaborations between PhD students from different laboratories. The Symposium will consist of both moderated poster sessions and oral communication sessions by PhD students, providing ample time for discussion both within and outside the scientific sessions. In addition to the regular presentations, we have scheduled an invited keynote lecture on professional scientific skills and career guidance that will be inspirational for young researchers. The meeting will be held in English. The Symposium has the major aim of preparing our future PhDs for an excellent performance in critical exposition and data discussion both for their thesis defense and future scientific meetings. We expect original research and lively discussions on a broad range of topics within Health Sciences and Biomedicine between clinical and basic researchers from our faculty, hospitals and associated centers of research. We hope you enjoy the Symposium, Juan Antonio Vargas Núñez Dean of the Faculty of Medicine (UAM) Honorary President of the Symposium www.ibjournals.com Committees www.ibjournals.com Organizing Committee Francisco García Río. Coordinator of the PhD Programme in Medicine and Surgery. School of Medicine, UAM. Miguel Garzón. Professor of the PhD Programme in Neuroscience. School of Medicine, UAM. Susana Guerra. Vicedean for Research. School of Medicine, UAM. Oscar Lorenzo. Vicedean for Postgraduate Studies. School of Medicine, UAM. María Márquez. Coordinator of the PhD Programme in Clinical Psychology. Faculty of Psychology, UAM. Concha Peiró. Coordinator of the PhD Programme in Pharmacology and Physiology. School of Medicine, UAM. Fernando Rodríguez Artalejo. Coordinator of the PhD Programme in Epidemiology and Public Health. School of Medicine, UAM. Isabel Sánchez Pérez. Coordinator of the PhD Programme in Molecular Biosciences. School of Medicine, UAM. www.ibjournals.com Scientific Committee Julián Aragonés. Department of Medicine, School of Medicine, UAM. José Luis Ayuso. Department of Psychiatry, School of Medicine, UAM. Martina Bécares Palacios. Department of Preventive Medicine, Public Heath and Microbiology, School of Medicine, UAM. Luís M. Blanco Donoso. Department of Biological and Health Psychology, Faculty of Psychology, UAM. Alberto Borobia. Clinical Pharmacology, Hospital Universitario La Paz. Ana Briones. Department of Pharmacology, School of Medicine, UAM. Rafael Cabrera. Department of Medicine, School of Medicine, UAM. Guillermo de Cárcer. Spanish National Cancer Research Center (CNIO). Javier de Castro. Department of Medicine, School of Medicine, UAM. Javier Egea. IIS-La Princesa. Ana Frank. Department of Medicine, School of Medicine, UAM. Juan Ángel Fresno. INGEMM, Hospital Universitario La Paz. María García-Amado. Department of Anatomy, Histology and Neuroscience, School of Medicine, UAM. Eva García Perea. Departmental Section of Nursing, School of Medicine, UAM. Rubén García Sánchez. Department of Psychology, School of Health Sciences, La Salle, UAM. Miriam Granado. Department of Physiology, School of Medicine, UAM. Gabriel Herrero Beaumont. Department of Medicine, School of Medicine, UAM. Miguel A. Iñiguez. Department of Molecular Biology, Faculty of Sciences, UAM. José Antonio López. Department of Molecular Biology, Faculty of Sciences, UAM. José Luis López Sendón. Department of Medicine, School of Medicine, UAM María Monsalve. IIBm, UAM-CSIC. Gema Moreno. Department of Biochemistry, School of Medicine, UAM. Juan Antonio Moreno. IIS-Fundación Jiménez Díaz. Antonio Pérez Martínez. Department of Pediatrics, School of Medicine, UAM. Luis del Peso. Department of Biochemistry, School of Medicine, UAM. César Porrero. Department of Anatomy, Histology and Neuroscience, School of Medicine, UAM. José María Portolés. Department of Medicine, School of Medicine, UAM Ricardo Sánchez Prieto. IIBm, UAM-CSIC. Leandro Soriano. Department of Pediatrics, School of Medicine, UAM. Miguel Ángel Rodríguez Gabriel. Department of Molecular Biology, Faculty of Sciences, UAM. Tania Romacho. Department of Pharmacology, School of Medicine, UAM. Ana I. Rojo. Department of Biochemistry, School of Medicine, UAM Carlos F. Sánchez Ferrer. Department of Pharmacology, School of Medicine, UAM. Rafael Selgas. Department of Medicine, School of Medicine, UAM. www.ibjournals.com Technical Committee Technical Secretariat Sandra García Information Technologies Francisco Vara Susana Molina Audiovisual Support Juan Carlos Palomino PhD Students Manuel Albert Sola. PhD Programme in Microbiology. Ar Arij. PhD Programme in Microbiology. Beatriz Fernández Varas. PhD Programme in Molecular Biosciences. Irene Francisco Recuero. PhD Programme in Molecular Biosciences. Tamara Giménez Fernández. PhD Programme in Clinical and Health Psychology. José Antonio Noriega Prieto. PhD Programme in Neuroscience. Isabel Pérez Santos. PhD Programme in Neuroscience. Sara Pulido Sánchez. PhD Programme in Molecular Biosciences. Laura Rodríguez Mondragón. PhD Programme in Clinical and Health Psychology. Alejandra Romero Martínez. PhD Programme in Pharmacology and Physiology. Inés Valencia Fernández. PhD Programme in Pharmacology and Physiology. Cristina Vázquez Carballo. PhD Programme in Pharmacology and Physiology-IIS-FJD. www.ibjournals.com www.ibjournals.com Sponsors www.ibjournals.com www.ibjournals.com Programme www.ibjournals.com Registration 8:30-9:00 Main Hall Welcome & Opening 9:00-9:15 Aula Magna Oral Session 1 Neuroscience Aula Magna Chairpersons: 9:15-10:45 María García-Amado (Dpto. AHyN, UAM) Ana. I Rojo (Dpto. Bioquímica, UAM) 1.1. NEURO01 Noradrenaline innervation in the primate thalamus: similarities and differences in macaques and human. I. Pérez Santos 1.2. BIO12 The role of p27kip1 in the development, differentiation and maturation of mesencephalic dopaminergic neurons. C. Palmer 1.3. BIO27 The role of PKD1 in brain injury: ROS detoxification and neuroprotection. J. Pose 1.4. MED19 The response to a high fat diet in a mouse model of Alzheimer’s disease is sexually dimorphic. A. Freire-Regatillo 1.5. MED23 Exosomes as predictive biomarkers in acute ischemic stroke patients: a traslational research approach. E. Alonso López 1.6. PHAR08 Effect of antidepressants of clinical use on neuronal nicotinic acetylcholine receptors. I. Gameiro-Ros Oral Session 2 Endocrinology, Metabolism and Immunoinflammation Seminario 1 9:15-10:45 Chairpersons: Juan Antonio Moreno (IIS-Fundación Jiménez Díaz) Julián Aragonés (Dpto. Medicina, UAM) 2.1. MED06 Study of genetic basis of idiopathic central precocious puberty. N.V.Ortiz- Cabrera 2.2. BIO07 A novel role for the Hippo pathway mediator TAZ in thyroid differentiation. C. Fernández-Méndez 2.3. BIO19 The Role of Liver X Receptors in the homeostasis of Splenic Red Pulp Macrophages and Iron Metabolism. M. C. Orizaola 2.4. BIO26 Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid athritis. S. Pérez-Baos 2.5. PHAR04 Anakinra prevents interleukin-1β-dependent endothelial damage and vascular smooth muscle inflammation in diabetic vasculopathy.A. San Hipólito Luengo Coffee & Poster Viewing 10:45-11:15 Main Hall Oral Session 3 Cardiovascular and Renal Aula Magna 11:15-12:45 Chairpersons: José Luis López Sendón (Dpto. de Medicina, UAM) Rafael Selgas (Dpto. de Medicina, UAM) 3.1. PHAR10 Oxidative stress is linked to lifetime cardiovascular risk stratification in young/middle age individuals. E. Rodríguez-Sánchez 3.2. MED17 Adequacy of antithrombotic treatment, characteristics and in-hospital mortality of elderly patients with non-valvular atrial fibrillation: results of the NONAVASC registry. A. Gullón 3.3. PHAR02 The noncanonical Notch ligand DLK1 regulates renal inflammation. L. Márquez Expósito 3.4. PHAR05 Pharmacogenetic algorithm for acenocumarol dosing improve anticoagulation control: a multicenter randomized clinical trial. H.Y. Tong 3.5. MED07 Comparison of pharmacological treament alone versus treatment