127 4. Berl et al. Mechanism of allergic contact dermatitis from Piroxin; Fr. : Brexin; Cycladol; Feldene; Geldene; Inflacedt; 3-(4-[2-(1-p-Chlorobenzoyl-5-methoxy,2-methylindol-3-yia­ V, Proxalyoc; Zofora; Ger.: Brexidolt; Flexaset; Pirobeta; Piroflam; propacetamol: sensitization to activated N,N-diethylglycine. Contad cetoxy)eth)'i}piperazln-1-yl)propyt '4cbenzamldo-N,N,dipro­ 38: Pirox; Gr. : Bleduran; Brexin; Calmopyrol; Conzila; Feldene; Dermatitis I998; 185-8. pylglutaramate dimaieate. 5. Hersch M, et al. Effect of intravenous propacetamol on blood pressure in Fidinor; Flodeneu; Grecotens; Inflamase�N; Neo Axedil; Nilvo; febrile critically patients. Pharmacotherapy 2008; 28: I205-IO. Oximezin; Painrelipt�D; Pedifan; Propanol; Pyrcost; Reumaplus; 076.6 ill C�,HsaCIN50s,2C;H,04� 1 Ruvamed; Sinartrol; Valopon; Zerospasm; Zitumex; Hong Kong: Porphyria. The Drug Database for Acute Porphyria, com­ cinc� s ·-,57,�32�53�3 {,orogh:meracin); 59209-40-4 (.orogturn'eta­ CP-Pirox; Feldene; Mobilist; Piram-Dt; Piroxicat; Sefdene; piled by the Norwegian Porphyria Centre (NAPOS) and Synoxicamt; Vidapirocamt; Hung. : Brexin; Feldene; Flamexin; maleate). the Porphyria Centre Sweden, classifies propacetamol as Hotemin; Pirorheumt; India: Amida; Brexic; Camrox; Camsun; ATC - MOIA814. probably not porphyrinogenic; it may be used as a drug of Cycladol; Dolocare; Dolocip; Dolodil; Dolokam; Dololup; Dolo� ATC vet - 0MO/A8l4. first choice and no precautions are needed.1 nex; Dolopir; Doloswift; Dupox; Estcom; Felcam; Feldex; Flex� UN!/ - F2PUN24B8C ar; Kemonex; Lincitrax; Medicam; Meloxi; Micropec; Mobicam; I. The Drug Database for Acute Porphyria. Available at: http:l/www. drugs-porphyria.org (accessed II !10/11) Mobidin; Movon; Noxicam-MD; Pam; Panorox; Pirox; Suganril; ; Profile Indon.: Faxident; Felcam; Feldene; Infeld; Kifadene; Lanareu­ Proglumetacin maleate, an indoleacetic add derivative P epa at ons ma; Licofel; Maxicamt; Pirocam; Pirodenet; Pirofel; Rexicam; .........r r .......i ................ .......... ......... ....... related to indometacin (p. 71.2), is an NSAID (p. 102.3). It ... Rexil; Rosict; Roxidene; Scandene; Sofdent; Tropidene; Xica� Proprietary Preparations (details are given in Volume B) lorn; Irl.: Feldene; Pericamt; Israel: Brexin; Exipan; Feldene; has been used in musculoskeletal and joint disorders in oral !tal. : Antiflog; Artroxicam; Brexidol; Brexin; Brexivel; Bruxi� doses of up to 600 mg daily, in divided doses. Proglumetacin Single�ingredient Preparations. Gr. : Pro-Dafalgant; Mex. : Tern� camt; Cicladol; Clevian; Dexicamt; Euroxi; Feldene; Flodol; maleate has also been given as rectal suppositories and pra. Ipsoflog; Kinski; Lampoflex; Lenotac; Pirobec; Piroftal; Reuma­ topically as a 5% cream. gil; Roxenet; Roxenilt; Roxiden; Sinartrol; Zelist; Jp n: Baxo; Malaysia: Brexin; Feldene; Rhumagel; Uphaxicam; Mex. : References. l. Appelboom T, Franchimont P. Proglumetacin versus indometacin in Androxicamt; Arlexicam; Artyflam; Asabont; Axtrim; Bapix� rheumatoid arthritis: a double-blind multicenter study. Adv Therapy ied; Bioximil; Brexicam; Brexodin; Brucam; Campirex; Citoken 1994; II: 228-34. T; Dixonal; Dolzycam; Edecamt; Facicam; Feldene; Glandicin; 2. Martens M. Double-blind randomized comparison of proglumetadn and Laspiro; Osteral; Oxi�Reul; Oxicanolt; Pirodaxt; Pirox; Pirox­ naproxen sodium in the treatment of patients with ankle sprains. Curr ant; R�Tyflamt; Reucam; Reutricam; Ripox; Serpicam; Tripirol; Ther Res 1995; 56: 639--48. Vatrem; Neth.: Brexinet; Norw. : Brexidol; NZ: Candyl; Piram- Dt; Pirohexal�Dt; Philipp.: Feldene; Flamastat; Flaxine; Macro� P epa a ons i .....r . r.. ti... .... xam; Neperlant; Palpasin; Parixamt; Pirostadt; Pixacor; Proxi� . ... .. ... ProprietaryPreparations (details are given in Volume B) max; Raxicam; Pol. : Feldene; Flamexin; Hotemint; Port.: Brex­ Propyl nicotinate is used in topical preparations as a in; Feldene; Flexar; Flogocant; Remisil; Reumoxican; Roxazin; Single-ingredient Preparations. Arg.: Bruxel; Belg.: Tolindol; rubefacient. Rus.: Erazon (3pa3oH); Finalgel (<I>rrnarrreni>); S.Afr. : Brexecam; Ger.: Protaxon; Hong Kong: Afloxan; Ital. : Proxil; Jpn: Mirida� Pixicam; Pyrocaps; Rheugesic; Roxifen; Xycam; Singapore: cin; Philipp.: Afloxan; Port. : Protaxil; Thai.: Afloxan. Feldene; Rhumagel; Rosiden; Roxifen; Sefdene; Vitaxicamt; Preparations . ..... .. ..... ....... ....... Spain: Brexinilt; Cycladolt; Feldegel; Feldene; Improntal; Sal­ ProprietaryPreparations (details are given in Volume B) vacam; Sasulen; Vitaxicamt; Swed. : Brexidol; Switz. : Felden; Ger.: Pirocamt; Pirosol; Thai.: Ammidene; Brexin; Butacinon; Cyclo­ Propacetamol Hydrochloride (BANM, r/NNM) Single-ingredient Preparations. Elacur. dex; Dexalin; Fasden; Felcam; Feldene; Felgesic; Felicam; Fel­ Hidrodoruro ropacetamo!; Propac€:tamol, Chiorhydrate nox; Felpac; Felrox; Felxicam; Flamic; Heropedd; Ifemed; de p de; Propacetamof, hidrociOiuro de; Propacetamol-hidroklor• Kobixam; Manoxicam; Maswin; Moxicamt; Neogelt; Neotica; Propyphenazone (BAN, r/NN} id; · Nutarzol; PC�20t; Pherazone; Pi�rock; Pidoxam; Piram; Pirax; . Propacetamolhydroch!orid; Propacetamoi-hydrochforid; lsopropylantipyrine; lsopropylantipyrinum; lsopropylphella­ Piraxil; Pircam; Pirox�Man; Pirox; Piroxal; Piroxam; Piroxcin; Propacetamolhydroklorid; Propacetamoli f1Ydrochlorrdum; · Piroxent; Piroxidon; Piroxone; Piroxsil; Polyxicam; Posedenet; Propacetamolio hldrochloridas; Propasetamolihydrokloridi; zo ne; Propifetiazon; Propifenazoria; Propifenazonas; Propy' Rocki; Roxicam; Roxifen; Roxium; Roxycam; Roxycan; Ruma� nponalieTa Moria V!ApoXJJopt�LI- fenatsoni; Propyfenazoni Propypiienazon; Propyphenazo ne; dene; Rumaxicam; Setarox; Sotilen; Spamic; Verox; Xicam; The hydrochlorider of N/11-diethyiQIYc'ine ester .with Propypnenazonum: flponrir¢er;il30fl Turk.: Cycladol; Felden; Inflamext; Oksikam; UK: Brexidol; cetai11ol; 4-AcetamJdopheriyl diethylaminoacetate hydro­para­ 4-fsopropyi-2,3.Jimethyl-1-phef1}·1-3-pyrazolin-5-one. Feldene; Ukr.: Finalgel (cDimarrreni>); USA: Feldene; Venez. : C:.H,8Nl(}.,230.3 Feldene; Feldenedi; Flamalit; Maxipiro; Pixorid. chloride. Arg.: C45 - 479-91-5. Multi-ingredient Preparations. Buta Rut Bl2; Flexicamin A; Ct,H-,oNz03.HCJ=300.866532-85-2 Flexicamin Bl2; Flexicamin Bl2; Flexicamin; Flogiatrin Bl2; AT(- N028804. CA S -· (p ropacetamoO. Flogiatrin Bl2; Flogiatrin; Peganix; Rumisedan Fuerte; Rumise� AIC Vet--'- -- A TC Ve t N02BE05.- dan; Solocalm Plus; Solocalm Plus; Solocalm�B; Solocalm�Flex; ATC ONO:!BE05 UN/1 nFilRFlt7<;>'Y Braz. : Rheumafim; India: Capsidal; Indon.: Counterpain�PXM; Pharmacopoeias. In Bur. (see p. vii) and Jpn. (}Nil - Sl-t4TQYH8E5. Thai. : Counterpain Plus. Pharmacopoeias. In Bur. (see p. vii). Ph. Eur. 8: (Propyphenazone). A white or slightly yellowish crystalline powder. Slightly soluble in water; freely soluble Ph. Eur. 8: (Propacetamol Hydrochloride). A white or PharmacopoeialPreparafions in alcohol and in dichloromethane. Protect from light. BP 2014: Piroxicam Capsules; Piroxicam Gel; almost white crystalline powder. Freely soluble in water; USP 36: Piroxicam Capsules; Piroxicam Cream. slightly soluble in dehydrated alcohol; practically insoluble in acetone. Protect from moisture. Profile Propyphenazone, a pyrazolone derivative related to Pranoprofen (r!NN) Profile phenazone (p. 124.1), has analgesic and antipyretic properties. It has been given orally and as a rectal Pranoprofe f1<;; ranoprofeno; Pranoprofenum; flpaHonpo­ Propacetamol hydrochloride, a para-aminophenol deriva­ P suppository in the treatment of pain and fever. The usual tive. is hydrolysed to paracetamol (p. 115.1) in the plasma; oral dose is 0.5 to I g up to four times daily. There have been I g of propacetamol hydrochloride is hydrolysed to release ¢eH.a-Meth yt-5H-[1l-benzopyrano[2,3-b]pyridii1,.7-acetic acid. some reports of severe hypersensitivity reactions in patients about 500 mg of paracetamol. It has been given receiving propyphenazone. intramuscularly or intravenously for the treatment of pain C,5H,,-N03S255.3 C4S 5254!/-17-4. and fever. P ep r �r�ti?n.�................ ATC-SOI- BC09. References. Allegaert K, et al. Phannacokinetics of single dose intravenous (details are given in Volume B) ATC Vet QS01 BC09. l. ProprietaryPreparations propacetamol in neonates: effect ot gestational age. Arch Dis Child Fetal UN!! �.2Eil07ET613. 89: Single·ingredient Preparations. Ger.: Demex. Pharmacopoeias. In Jp n. Neonatal Ed 2004; F25-F28. 2. Walson PD, et al. efficacy and tolerability of a single MultHngredient Preparations. Arg.: Algio�Bladuril; Espasmo intravenous dose of acetaminophen prodrug propacetamol in Cibalena; Saridon; Austria: Adolorin; Avamigran; Gewadal; children: a randomized, double-blind, placebo-controlled trial. Clin Ther Melabon; Migradon; Montamed; Nervan; Rapidol; Saridon; Profile 2006; 28: 762-9. Pranoprofen, a propionic acid derivative, is an NSAID 3. Prins SA, et al. Pharmacokinetico;; and analgesic effects of intravenous Spasmoplus; Tonopan; Vivimed; Braz.: Saridon; Tonopan; Chile: Abalgin; Droxelt; Espasmo Cibalgina Compuestat; (p. 102.3). It is used as eye drops in a concentration of 0. 1% propacetamol vs rectal paracetamol in children after major craniofacial surgery. Paediatr Anaesth 2008; 18: 582-92. Espasmo Cibalgina; Gripasan Compuesto DN; Gripasan Com� for ocular inflammation. Pranoprofen has also been given 4. McNicol ED, et a!. Single-dose intravenous paracetamol or propacetamol puesto; SAE; China: Saridon Cz. : Saridon; Valetol; orally for the treatment of pain, inflammation,