SUPPLEMENT 1 Book of abstracts of Gynecological Endocrinology the 19th World Congress WWW.GREMJOURNAL.COM VOLUME 1 • SUPPLEMENT 1 • 2020 Fertility nspired by nature IBSA Institut Biochimique SA Via del Piano 29, 6915 Lugano, Switzerland www.ibsagroup.com ADV20_FertilityLine_Final.indd 1 02.03.20 15:35 VOLUME 1 • SUPPLEMENT 1 • 2020 Editor In Chief Andrea R. Genazzani (IT) Editorial Board Leila Adamyan Efthimios Deligeoroglou Pauline Maki Joseph Schenker Farook Al-Azawi Gian Carlo Di Renzo Paolo Mannella Adolf Schindler Stefano Angioni Marie-Madeleine Dolmans Takeshi Maruo Michael Schumacher David Archer Jacques Donnez Tamaki Matsumoto John J. Sciarra Jean-Francois Arnal Rene Druckman Blazej Meczekalski David Serfaty Paolo Artini Fabio Facchinetti Jose Mendez Ribas Duru Shah Edmund Baracat Dov Feldberg Maria Cristina Meriggiola Carlos Simon Eytan Barnea Xiaodong Fu Joannis Messinis Tommaso Simoncini Pedro Barri Tomoyuki Fujii Andrzej Milewicz Christian Singer Patricio Barriga Luis Miguel Garcia Segura Edgar Mocanu Nestor Siseles Chiara Benedetto Kristina Gemzell Danielsson Patrizia Monteleone Regine Sitruk-Ware Sarah Berga Alessandro Genazzani Philippe Morice Sven Skouby Nicoletta Biglia Sandro Gerli Alfred Mueck Antonina Smetnik Martin Birkhaeuser Andrea Giannini Frederick Naftolin John Stevenson Johannes Bitzer Dimitrios Goulis Rossella Nappi Jerome Strauss J.F Edoardo Borges Da Fonseca Alessandra Grazziottin Jose Luis Neyro Charles Sultan Mark Brincat Angelica Hirshberg Linden Michelle Nisolle Basil Tarlatzis Roberta Brinton Diaz Moshe Hod Santiago Palacios Hugh Taylor Pavel Calda Ludwig Kiesel Nick Panay Robert Taylor Antonio Cano Sanja Kupesic Antonio Pellicer Ekaterine Tskitishvili Howard Carp Antonio La Marca Faustino Perez Lopez Filippo Ubaldi Salvatore Caruso Michele Lachowsky Felice Petraglia Richard Van Lunsen Cuauhtemoc Celis Irene Lambrinoudaki Nicola Pluchino Michael Van Trotsenburg Frederique Chantraine Stefano Lello Jean-Yves Reginster Anna Veiga Peter Chedraui Rogerio Lobo Alberto Revelli Gary Ventolini George Creatsas Patrice Lopes Walter Rocca Svetlana Vujovic Emile Darai Stefano Luisi Xiangyan Ruan Antoine Watrelot Nilson Roberto De Melo Mario Maggi Camilo Rueda Tevfik Yoldemir Publication management Feto-Maternal Medicine, Basic Science, Instructions for Authors BTpress Pharmacology, Epidemiology, Metabo- You can find instructions for submitting www.btcongress.com lism, Oncology, Neuro-Endocrinology manuscripts at: Editorial Manager Psycho-Somatic Medicine,Sexology, Fe- www.gremjournal.com/instructions/ Manuscripts should be submitted using Anna Kamola male Aging, Ethics, Quality of Life and any the on-line submission and manuscript other aspects of Gynecological and Repro- Production Office tracking system at: ductive Endocrinology and Metabolism. MediMay Communication Srl www.gremjournal.com/submit-an-article/ In particular articles related to Endocrine Via Giovanni Antonelli, 47 Warning to readers Therapies in women, Puberty, Adolescent 00139 Rome, Italy The Publisher declines all responsibility Gynecology, Contraception, Fertility, Po- [email protected] deriving from errors or omissions regard- The Journal lycystic Ovary, Endometriosis, Assist- ing the dosage and use of products possibly Gynecological and Reproductive Endo- ed Reproduction, Abortion, Eclampsia, mentioned in the articles, and invites the crinology and Metabolism, an Open-Ac- Gestational Diabetes Mellitus, Premature reader to personally check the accuracy, cess Journal of the ISGE, will publish Labor, Breast Feeding, Premature Ova- referring to the relative bibliography. Editorials, Statements, Position Papers, rian Insufficiency, Menopause, Female Address for correspondence Systematic Reviews, Meta-analysis, Short- Sexual Dysfunction, Osteoporosis, GSM/ Andrea R. Genazzani: Reviews, Ori ginal Articles and Case Re- VVA and any other topics related to Gy- [email protected] ports on the research area of the fields necological and Reproductive Endocri- Anna Kamola: [email protected] of Gynecology, Obstetrics, Reproduction, nology and Metabolism will be welcome. BTpress: [email protected] Copyright © - 2020 - International Society of Gynecological Endocrinology (ISGE) GREM is published quarterly in March, June, September and December by International Society of Gynecological Endocrinology INDEX 5 Editorial 6 Key Lectures 14 Symposia 62 Meet the Experts 73 Scholarship Courses 83 Scientific Societies Symposia 117 Oral Presentations 340 Poster Session 648 Sponsored Key Lectures 651 Sponsored Meet the Experts 654 Sponsored Symposia 660 Author index 4 Gynecological and Reproductive Endocrinology and Metabolism 2020; Supplement 1 – Book of asbtracts EDITORIAL Dear Friends For all Executive Committee of the International Society of GREM, includes all received abstracts of Key Lectures, Sympo- Gynecological Endocrinology is a pleasure to introduce the sia, Meet the Experts, Scientific Societies Symposia, 249 Oral Abstract Book of the 19th World Congress of Gynecological presentations, 350 Posters and the abstracts of the sessions or- Endocrinology (On Line Congress 2-5 December 2020, avail- ganized by our Sponsors. able until 15 April 2012) as Supplementum n. 1 of our New This volume contains also the abstracts of the Lectures of the Open-Access Journal: GREM – Gynecological and Reproduc- ISGE Scholarship Special Course for trainees and Post-Doc tive Endocrinology and Metabolism. who participated in our Scholarship Program. This represents a further effort of ISGE to promote investiga- We invite all of you to go to the third cover page of this book tions and education in Gynecological Endocrinology. GREM is and to accept our invitation: GREM is looking for your Manu- the demonstration of the vitality and worldwide engagement of script! ISGE to stimulate the upgrading of Gynecologists and Obste- I would like to express our gratitude to Peter Chedraui as Editor tricians in Gynecological and Reproductive Endocrinology and in Chief since January 2020 of our first journal: Gynecological Metabolism. Endocrinology, who started in March 1987, edited by Taylor The New Open-access GREM, edited by ISGE in collaboration and Francis, successfully growing as quality and number of pa- with BTpress and Medimay will publish all kind of papers: Ed- pers received and published. itorials, Statements, Position Papers, Reviews, Meta-analyses, With this in mind, I wish for all of you to enjoy the on-line par- Original Articles and Case Reports covering all areas of Gy- ticipation to the19th World Congress of Gynecological Endocri- necological, Obstetrical and Reproductive Endocrinology, and nology to enrich your culture and your knowledge in this fantas- Metabolism. tic discipline who covers areas of fundamental importance for The 19th World Congress Abstract Book, as Supplement n. 1 of women health and quality of life. Andrea R. Genazzani President of ISGE 5 Gynecological and Reproductive Endocrinology and Metabolism 2020; Supplement 1 – Book of asbtracts Key Lectures Key Lectures (KL02) The human yolk sac, perhaps the most important transient organ The human yolk sac, perhaps the most important transient organ Frederick Naftolin (US) Department of Obstetrics and Gynecology, New York University Grossman School of Medicine, New York, USA The human embryo-fetus develops several transient organs. These include the placenta, the fetal adrenal reticular zone and the yolk sac. While the first two are well-documented and studied, the yolk sac is generally only thought of as the source of endodermal mesenchymal precursor cells. Its early origins in the blastula are unstudied except for anatomic specimens that are characterized in a comparative biology context. Yet, the direct inclusion by the pincer-like action of the developing amniotic sac in the body of the embryo of the dorsal part of the (primary) yolk sac includes much of the precursors of the gut, blood and vessels and other systems in the corpus of the developing embryo-fetus. More such stem elements enter via the vitelline vessels before the (secondary) yolk sac is eclipsed and shunted off to the edges of the developing chorion-amnion interface. With the availability of high-resolution ultrasound, there has been a resurgence of studies on the morphology of the secondary yolk sac, primarily as a harbinger of the health of the developing embryo-fetus. Animal studies have shown the importance of the yolk sac in development. For example, comparatively small changes in glucose levels result in the increase in fetal anomalies that plagued the offspring of uncontrolled diabetics. Tight glucose control has reduced the rate of anomalies of diabetic pregnancies to less than that of normal pregnancies. With the availability of cells removed from embryos in vitro and dated products of conception from failed in vitro fertilization cases, the opportunity to properly study the yolk sac has arisen. Scientific study of this important transient organ should be a high priority in the coming decade. 7 Gynecological and Reproductive Endocrinology and Metabolism 2020; Supplement 1 – Book of asbtracts Key Lectures (KL06) Translational research with thyroid hormone in the placenta Translational research with thyroid hormone in the placenta Takeshi Maruo (JP) Kobe Children’s Hospital Clinically it is known that hypothyroidism is one of the endocrine factors for early pregnancy loss. Corpus luteum is the prime source of P4 production in very early pregnancy, and placenta takes over the corpus luteum function at 6- week of pregnancy.