US009504742B2 a2) United States Patent (10) Patent No.: US 9,504,742 B2 Dickeyetal. (45) Date of Patent: Nov. 29, 2016 (54) COMPOSITIONS FOR STIMULATION OF 5,238,944 A 8/1993 Wick et al. veces 514/293 MAMMALIAN INNATE IMMUNE 5,266,575 A 11/1993 Gerster et al. .. .. 514/293 5,268,376 A 12/1993. Gester ......... .. 514/293 RESISTANCE TO PATHOGENS 5,346,905 A 9/1994. Gerster vce .. 514/293 (71) Applicant: The Board of Regents, The University 5,352,784 A 10/1994 Nikolaides etal. .. 544/126 of Texas System.ystem, Austin, , TX (US)(US 5,389,640 A 2/1995 Gerster et al. we 514/293 TX 5,395,937 A 3/1995 Nikolaides et al. ........... 546/82 (72) Inventors: Burton Dickey, Houston, TX (US); oaee13s A wyee Metzgeretal. eee eno ta Michael‘.Tuvim, Houston, TX (US);. 5,494,916’ 5 A 2/1996 Lindstromatton et al.et al........sss.... 514/303. 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