Supplementary file 2: Gene expression changes in the brain mononuclear cells of CD47 KO mice This table contains a list of all gene expression changes in the brain mononuclear cells of CD47 KO mice ( > 2-fold: Log2 ratio > 1 or < -1) Expression of total 16,544 genes was detected in both or either of the genotypes. Genes (with different probe set ID#) found in both of the increased and decreased gene groups were excluded from the table. 1,323 and 2,286 genes were markedly (> 2-fold) increased and decreased, respectively, in CD47 KO compared with WT mice. column name description probe set ID# Affymetrix probe set ID number for Mouse 430 2.0 Genome Arrays gene gene description symbol gene symbol accession NCBI accession number Log2 ratio Gene expression fold change expressed as Log2 (KO/WT) probe set ID# gene symbol accession Log2 ratio 1423527_at coiled coil glutamate rich protein 1 Ccer1 AK006212 7.05 1445945_at expressed sequence AU021880 AU021880 BG068075 6.88 1457245_at disrupted in renal carcinoma 2 (human) Dirc2 AW988060 6.49 1429495_at transmembrane protein 107 Tmem107 AV007348 6.40 1458849_at N-acylsphingosine amidohydrolase 2 Asah2 BB234186 6.07 1425994_a_at N-acylsphingosine amidohydrolase 2 Asah2 AB037111 1.45 Rpl31 /// Rpl31- 1436144_at ribosomal protein L31 /// ribosomal protein L31, pseudogene 1 2 BG802091 5.94 ps12 1444594_at T-box 3 Tbx3 AA024086 5.88 1441354_at expressed sequence AU018740 AU018740 BG069312 5.79 1434425_at trichohyalin Tchh AI597080 5.66 1427447_a_at TRIO and F-actin binding protein Triobp BC003984 5.56 1447139_at B cell CLL/lymphoma 7C Bcl7c BM234097 5.20 1446516_at B cell CLL/lymphoma 7C Bcl7c BB176719 2.22 1423476_at solute carrier family 46, member 2 Slc46a2 BB329435 5.19 1441845_at calcyphosphine 2 Caps2 BB388044 5.15 1454442_at BCL2/adenovirus E1B interacting protein 2 Bnip2 AK017785 5.12 1440158_x_at coiled-coil-helix-coiled-coil-helix domain containing 7 Chchd7 BB209663 5.09 1437092_at CAP-GLY domain containing linker protein family, member 4 Clip4 AV042829 5.04 1458014_at AF4/FMR2 family, member 2 Aff2 BB245809 5.02 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated 1447829_x_at Taf9b BB431174 5.00 factor 1435471_at zinc finger protein 708 Zfp708 BE994129 4.98 1454213_at armadillo repeat containing 9 Armc9 AK019512 4.93 1428399_a_at armadillo repeat containing 9 Armc9 AK017564 2.11 1417207_at dishevelled 2, dsh homolog (Drosophila) Dvl2 BF466091 4.90 1454160_at glutamate receptor interacting protein 1, opposite strand 1 Grip1os1 AK019561 4.90 1446974_at phosphoinositide kinase, FYVE finger containing Pikfyve BM220925 4.85 1447444_at UBX domain protein 11 Ubxn11 AW495835 4.71 1457323_at single-pass membrane protein with coiled-coil domains 3 Smco3 AI846508 4.65 1424630_a_at breast cancer 1 Brca1 U31625 4.54 1451417_at breast cancer 1 Brca1 U31625 4.33 1439981_at thymocyte expressed, positive selection associated 1 Tespa1 BB198298 4.51 1438747_at RIKEN cDNA A930006K02 gene A930006K02Rik BF020563 4.44 1442196_at RIKEN cDNA A930006K02 gene A930006K02Rik BB174109 1.19 1444686_at family with sequence similarity 173, member B Fam173b BB279561 4.40 1435572_at RIKEN cDNA 2310014L17 gene 2310014L17Rik AV232798 4.40 1442292_at Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 Arhgef6 BB474042 4.35 1425102_a_at angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 Ace2 AB053181 4.33 1447368_at maestro heat-like repeat family member 2A Mroh2a BF019000 4.21 1453458_at RIKEN cDNA 9430019C24 gene 9430019C24Rik BM121183 4.19 1441118_at family with sequence similarity 222, member B Fam222b BB389461 4.13 1419220_at xin actin-binding repeat containing 1 Xirp1 NM_011724 4.07 a disintegrin-like and metallopeptidase (reprolysin type) with 1444253_at Adamts18 BM117857 4.06 thrombospondin type 1 motif, 18 a disintegrin-like and metallopeptidase (reprolysin type) with 1446247_at Adamts18 BB125422 2.87 thrombospondin type 1 motif, 18 1460030_at HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Hecw1 BB355811 4.05 1440656_at HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Hecw1 BB458541 1.06 1425985_s_at mannan-binding lectin serine peptidase 1 Masp1 AB049755 4.05 1419677_at mannan-binding lectin serine peptidase 1 Masp1 NM_008555 1.10 1453584_at serine/threonine kinase 36 Stk36 AK007188 4.04 1456777_at maltase-glucoamylase Mgam BB072761 4.03 1416693_at forkhead box C2 Foxc2 NM_013519 3.97 probe set ID# gene symbol accession Log2 ratio 1442579_at RIKEN cDNA 9330111N05 gene 9330111N05Rik BB306259 3.94 1433361_at RIKEN cDNA 4930527F18 gene 4930527F18Rik AK015915 3.94 Gm3417 /// predicted gene 3417 /// predicted gene 3448 /// t-complex-associated 1421682_a_at Gm3448 /// NM_011560 3.92 testis expressed 3 Tcte3 1440888_at oxytocin receptor Oxtr BB551848 3.88 1455980_a_at growth arrest-specific 2 like 3 Gas2l3 BB770972 3.87 1437244_at growth arrest-specific 2 like 3 Gas2l3 BB770972 1.73 1433652_at immunoglobulin superfamily, member 1 Igsf1 AV245981 3.78 1438589_at immunoglobulin superfamily, member 1 Igsf1 BB023061 2.43 Mus musculus adult male testis cDNA, RIKEN full-length enriched library, AK076909 /// 1459129_at clone:4930548A09 product:unclassifiable, full insert sequence. /// --- /// Gm20616 /// AV270194 3.78 predicted gene 20616 Gm20616 1444197_at Ras and Rab interactor-like Rinl BB163345 3.77 A630072M18Ri 1427081_at RIKEN cDNA A630072M18 gene BB246700 3.76 k 1455382_at ZW10 interactor Zwint AV130073 3.76 1456862_at sine oculis-related homeobox 4 Six4 AI893638 3.75 1415935_at SPARC related modular calcium binding 2 Smoc2 NM_022315 3.74 1430484_at RIKEN cDNA 8430428J23 gene 8430428J23Rik AK018447 3.72 1422922_at RecQ protein-like 4 Recql4 NM_058214 3.72 1420735_at gamma-aminobutyric acid (GABA) C receptor, subunit rho 2 Gabrr2 AF024621 3.70 1432275_at inhibitor of kappaB kinase beta Ikbkb AK011359 3.69 1454184_a_at inhibitor of kappaB kinase beta Ikbkb AK011359 1.55 1430895_at RIKEN cDNA 2010109A12 gene 2010109A12Rik BF018972 3.67 1441950_s_at RIKEN cDNA 2010109A12 gene 2010109A12Rik AV064063 3.57 1441951_x_at RIKEN cDNA 2010109A12 gene 2010109A12Rik AV064063 2.74 1459544_at lipoyltransferase 1 Lipt1 BB180990 3.65 1417281_a_at matrix metallopeptidase 23 Mmp23 NM_011985 3.61 1430589_at phosphatidylinositol glycan anchor biosynthesis, class H Pigh AK020902 3.61 1450215_at recoverin Rcvrn NM_009038 3.57 1449502_at deleted in azoospermia-like Dazl NM_010021 3.54 1446425_at EF-hand calcium binding domain 14 Efcab14 BB075807 3.54 1459211_at GLI-Kruppel family member GLI2 Gli2 AW546128 3.53 1457626_at DNA segment, Chr 3, Wayne State University 106, expressed D3Wsu106e AA407555 3.49 1429932_at RIKEN cDNA 4930566F21 gene 4930566F21Rik AV215452 3.49 1430879_at RIKEN cDNA C030008P14 gene C030008P14Rik BB283753 3.47 1442079_at sphingomyelin synthase 1 Sgms1 BM238389 3.47 1450190_at zinc finger protein 106 Zfp106 NM_009165 3.46 1439279_at RIKEN cDNA 3110007F17 gene 3110007F17Rik AV339304 3.42 1430312_at tryptophan rich basic protein Wrb AK021091 3.41 Gm20515 /// 1440714_at predicted gene 20515 /// --- BB083283 3.40 Gm20515 1439712_at integrator complex subunit 10 Ints10 BB668046 3.40 1450094_at RAN binding protein 17 Ranbp17 NM_023146 3.39 1427238_at F-box protein 15 Fbxo15 AF176530 3.35 1422396_s_at achaete-scute complex homolog 2 (Drosophila) Ascl2 NM_008554 3.33 1456714_at WW domain containing E3 ubiquitin protein ligase 2 Wwp2 BB217820 3.32 1428800_a_at pseudouridylate synthase 7 homolog (S. cerevisiae)-like Pus7l AK019372 3.32 Gm13235 /// predicted gene 13235 /// predicted gene 13242 /// predicted gene 13247 Gm13242 /// 1445924_at BG065840 3.30 /// predicted gene, 21082 Gm13247 /// Gm21082 1419519_at insulin-like growth factor 1 Igf1 NM_010512 3.29 1452014_a_at insulin-like growth factor 1 Igf1 AF440694 1.97 1420471_at hypocretin Hcrt NM_010410 3.29 1445445_s_at prostaglandin E receptor 1 (subtype EP1) Ptger1 BB283614 3.27 1445653_at cDNA sequence BC031361 BC031361 BB825492 3.27 1431547_at RIKEN cDNA 4930435F18 gene 4930435F18Rik AK015323 3.25 1449153_at matrix metallopeptidase 12 Mmp12 BC019135 3.20 1419141_at crystallin, gamma D Crygd NM_007776 3.19 1444744_at death inducer-obliterator 1 Dido1 BF461970 3.19 1448719_at transcriptional adaptor 3 Tada3 AK003405 3.19 1458246_at uncharacterized LOC102632313 LOC102632313 BM934733 3.17 1457824_at phospholipid scramblase 1 Plscr1 AI504076 3.15 1440000_at RIKEN cDNA E330013P04 gene E330013P04Rik BG069958 3.14 1419751_x_at solute carrier family 22, member 27 Slc22a27 NM_134256 3.14 1457582_at ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome Uty BB528233 3.14 probe set ID# gene symbol accession Log2 ratio 1426598_at ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome Uty BB742957 1.76 1422247_a_at ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome Uty NM_009484 1.05 1427227_at gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Gabrg1 AF156490 3.13 1427026_at myosin, heavy polypeptide 4, skeletal muscle Myh4 AJ278733 3.11 1444771_at ankyrin repeat and BTB (POZ) domain containing 2 Abtb2 BB228490 3.11 1444386_at phosphodiesterase 1C Pde1c BB388392 3.10 1422330_at glucagon-like peptide 1 receptor Glp1r NM_021332 3.05 1444163_at NIMA (never in mitosis gene a)-related expressed kinase 5 Nek5 BB049667 3.04 1448426_at sarcosine dehydrogenase Sardh BI217574 3.04 Gm19569 /// 1456990_at predicted gene, 19569 /// --- BB199484 3.02 RP24-364K9.3 1460103_at predicted gene, 26598 Gm26598 BG071165 3.01 1457273_at teneurin transmembrane protein 2 Tenm2 BM899576 3.01 1429990_at