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Downloaded from Use of Intravenous Magnesium Sulfate among Patients with Acute Myocardial Infarction in China from 2001 to 2015: China PEACE-Retrospective AMI Study ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2019-033269 Article Type: Original research Date Submitted by the 29-Jul-2019 Author: Complete List of Authors: Wang, Xianqiang; National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Du, Xue; National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Yang, Hao; National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical http://bmjopen.bmj.com/ Sciences and Peking Union Medical College, Beijing, People's Republic of China Bucholz, Emily ; Center for Outcomes Research and Evaluation, Yale- New Haven Hospital Downing, Nicholas ; Center for Outcomes Research and Evaluation, Yale- New Haven Hospital Spertus, John; St. Luke's Mid America Heart Institute, Cardiovascular Outcomes Research Masoudi, Fredrick; University of Colorado Anschutz Medical Campus, on September 25, 2021 by guest. 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Medicine Li, Jing; National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Guan, Wenchi; National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Gao, Yan; National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China Hu, Shuang; National Clinical Research Center of Cardiovascular For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 75 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2019-033269 on 26 March 2020. Downloaded from 1 2 3 Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai 4 Hospital, National Center for Cardiovascular Diseases, Chinese Academy 5 of Medical Sciences and Peking Union Medical College, Beijing, People's 6 Republic of China 7 Bai, Xueke; National Clinical Research Center of Cardiovascular Diseases, 8 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National 9 Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of 10 China 11 Krumholz, Harlan; Yale-New Haven Hospital Center for Outcomes 12 Research and Evaluation, 13 Li, Xi; National Clinical Research Center of Cardiovascular Diseases, 14 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National 15 Center for Cardiovascular Diseases, Chinese Academy of Medical 16 Sciences and Peking Union Medical College, Beijing, People's Republic of For peerChina review only 17 18 Keywords: acute myocardial infarction, Magnesium Sulfate, quality of health care 19 20 21 22 23 24 25 26 27 28 29 30 31 32 http://bmjopen.bmj.com/ 33 34 35 36 37 38 39 40 on September 25, 2021 by guest. 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Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 75 BMJ Open 1 2 3 Use of Intravenous Magnesium Sulfate among Patients with Acute Myocardial 1 BMJ Open: first published as 10.1136/bmjopen-2019-033269 on 26 March 2020. Downloaded from 4 5 2 Infarction in China from 2001 to 2015: China PEACE-Retrospective AMI Study 6 7 3 8 9 10 4 Running head: Magnesium Sulfate for AMI in China 11 12 5 13 14 6 Xianqiang Wang*, MD; Xue Du*, MD; Hao Yang; Emily Bucholz, MD PhD; Nicholas 15 16 7 Downing, MD; John A. Spertus, MD, MPH; Frederick A Masoudi, MD, MSPH; Jing Li, 17 18 8 MD, PhD; WenchiFor Guan, peer MD; Yan Gao; review Shuang Hu, PhD;only Xueke Bai, MS; Harlan M. 19 20 9 Krumholz#, MD SM; Xi Li#, PhD; for the China PEACE Collaborative Group (see 21 22 10 Appendix A) 23 24 11 25 26 12 * Contribute equally 27 28 # Co-senior authors 29 13 30 31 14 32 33 15 National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory 34 35 16 of Cardiovascular Disease (XW, XD, HY, JL, WG, YG, SH, XB, XL), Fuwai Hospital, 36 37 17 National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences http://bmjopen.bmj.com/ 38 39 18 and Peking Union Medical College, Beijing, People's Republic of China; 40 41 19 Saint Luke’s Mid America Heart Institute and the University of Missouri-Kansas City 42 43 20 (JAS), Kansas City, Missouri, United States; 44 on September 25, 2021 by guest. Protected copyright. 45 21 Division of Cardiology (FAM), University of Colorado Anschutz Medical Campus, 46 47 22 Aurora, Colorado, United States; 48 49 50 23 Center for Outcomes Research and Evaluation (HMK, EB, ND), Yale-New Haven 51 52 24 Hospital, New Haven, Connecticut, United States; Section of Cardiovascular 53 54 25 Medicine (HMK), Robert Wood Johnson Clinical Scholars Program (HMK), 55 56 26 Department of Internal Medicine, Yale University School of Medicine, New Haven, 57 58 27 Connecticut, United States; Department of Health Policy and Management (HMK), 59 60 28 Yale School of Public Health, New Haven, Connecticut, United States. 1 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 75 1 2 3 Correspondence: Dr Xi Li, National Clinical Research Center of Cardiovascular 1 BMJ Open: first published as 10.1136/bmjopen-2019-033269 on 26 March 2020.