Programme Book Welcome to #ECTS2021 08-11 May 2021 Brussels, Belgium 07 May Pre-congress day www.ects2021.org ECTS 2020 Final Programme Table of Contents Welcome Scientific Programme Information Acknowledgement �� � � � � � � � � � � � � � � � � 3 Welcome Message� � � � � � � � � � � � � � � � � � 4 Committees �� � � � � � � � � � � � � � � � � � � � � � 94 Abstract Reviewers / Abstract Book � � � 95 On Demand � � � � � � � � � � � � � � � � � � � � � � 95 Awards CME Accreditation �� � � � � � � � � � � � � � � � 95 ECTS Grants and Awards� � � � � � � � � � � � � 7 Industry Scientific Programme List of Exhibitors �� � � � � � � � � � � � � � � � � � 97 Sponsors / Supporters � � � � � � � � � � � � � � 98 ECTS@Home – Overview �� � � � � � � � � � � 15 Exhibitor and Supporter Company Programme Overview� � � � � � � � � � � � � � 16 Profiles � � � � � � � � � � � � � � � � � � � � � � � � � 101 Corporate Industry Symposia � � � � � � � 107 ECTS Congress 2020 Mini Corporate Symposia � � � � � � � � � � 111 Thursday, 22 October – Saturday, 24 October 2020 Speaker and Authors Thursday, 22.10.2020 Programme Overview �� � � � � � � � � � � � � 20 Invited Faculty Index��������������113 Scientific Programme � � � � � � � � � � � � � � 21 Authors Index �������������������116 Friday, 23.10.2020 Imprint & Data Protection ���������125 Programme Overview �� � � � � � � � � � � � � 26 Policies & Disclosures��������������126 Scientific Programme � � � � � � � � � � � � � � 27 Saturday, 24.10.2020 Programme Overview �� � � � � � � � � � � � � 36 Welcome to Scientific Programme � � � � � � � � � � � � � � 37 #ECTS2021 ePosters �� � � � � � � � � � � � � � � � � � � � � � � � � 46 08-11 May 2021 Brussels, Belgium 07 May Pre-congress day www.ects2021.org 1 Welcome ECTS 2020 Final Programme Acknowledgements ECTS thanks the following organisations for their continued support of the society. Welcome ECTS thanks the following organisations for their support of the 47th Calcified Tissue Society Congress 2020. Platinum Supporter Gold Supporter Silver Supporter Additional Supporters and Educational Grants 3 ECTS 2020 Final Programme Welcome Message Dear Colleagues, Welcome It is a great pleasure to welcome you to the ECTS 2020 Digital Congress� The 47th annual meeting of the European Calcified Tissue Society this year will take place virtually due to the COVID-19 pandemic that prevents traveling� However, we will still offer our delegates 3 months of education, split in the ECTS 2020 Live Prime Time that will be held on 22-24 October 2020, and the ECTS@Home series that will run from October to December 2020� ECTS serves as a forum for researchers and clinicians working in the musculoskeletal field to discover and discuss the latest advances and controversies in research and in the daily care of patients� ECTS 2020 Live Prime Time will include relevant hot clinical sessions to help managing patients going along the newest knowledge in the field� ECTS 2020 will also focus on the best and latest basic and translational science with renowned leaders in our field� We have implemented more opportunities for discussions and beside our traditional symposia and workshops, there will also be debates, educational and industry symposia� The ECTS Congress is recognised as a successful scientific meeting thanks to the large number of contributions coming via abstract submissions� We are committed to offer large visibility to promising abstracts by including them in the Live Prime Time plenary, concurrent oral and oral poster sessions� Whether you are a young investigator, clinician, basic scientist, allied health professional or industry representative, you will be exposed to the latest topics in our field� You can also enhance your scientific knowledge by attending eposter presentations� ECTS 2020 will include a New Investigator programme fully organised by our young leaders, the ECTS Academy� This programme will give the opportunity to new investigators to network virtually, share common interests and present their science in the Poster Forum and in the New Investigator Seminar� We will offer extensive interactivity throughout ECTS 2020 Digital� You can interact with speakers, moderators, sponsors and other delegates� You can also join or create your own chat room and discuss live hot topics in your daily practice� There will be experts’ live broadcast and you can ask questions in real time� Collaborations will also be highlighted in several joint sessions with international bone societies: ASBMR, our partners from China, Japan and Korea and new partners from Europe and beyond, including CABS, TERMIS, BMAS and ISEV� 4 ECTS 2020 Final Programme The educational programme will be expanded beyond the Live Prime Time, through the ECTS@Home weekly series, which will include a basic science National Day offered by the French society SFBTM, working group meetings, the ECTS/IFMRS expert forum, workshops, meet the experts sessions, clinical and basic updates, the East meets West symposium and the Mellanby training course� New this year we will have dedicated sessions for Allied Health Professionals, which will also include Welcome a Meet the Expert event, and the ECTS/ERA-EDTA workshop on Mineral and Bone Disorders in Chronic Kidney Diseases� I hope you will enjoy our virtual congress and ECTS@Home series� Warm regards, Anna Teti SPC Chair 5 Awards ECTS 2020 Final Programme Awardee Wall 2020 ECTS Grants & Awards ECTS Names Awards Awards STEVEN BOONEN CLINICAL RESEARCH Award In memory of Professor Steven Boonen, who sadly passed away during the ECTS 50th Anniversary Congress in Lisbon on 20 May 2013� ECTS would like to remember and honour Steven during its annual congress by introducing an annual Steven Boonen Clinical Research Award� Outi Mäkitie, MD, PhD Children’s Hospital, University of Helsinki Helsinki, Finland The Steven Boonen Clinical Research Award was supported by Amgen Europe. ECTS PHILIPPE BORDIER CLINICAL Award Doctor Philippe Bordier (1927-1977) contributed significantly to the bone field by developing bone histomorphometry, which he applied to the analysis of several bone diseases� His work and dynamism in science has been recognized in Europe and United States� Rajesh V Thakker, Prof University of Oxford Oxford, United Kingdom ECTS IAIN T BOYLE Award In memory of Professor Iain T Boyle (1935–2001) who contributed greatly to the field of mineral metabolism and his work on osteoporosis was known and acclaimed nationally and internationally� The award is open to young scientists who have made significant progress and contribution to the field of bone and calcified tissue� Andrea Palermo, MD, PhD Campus Bio-Medico University Rome Rome, Italy 7 ECTS 2020 Final Programme ECTS MIKE HORTON BASIC/TRANSLATIONAL Award Professor Mike Horton (1948-2010) was a hematologist-turned-basic scientist who made significant contributions in the bone field and beyond� He performed pioneering work in osteoclast biology which resulted, among other things, in the Awards recognition of the alpha v beta 3 integrin as a therapeutic target for inhibiting bone resorption� His warm personality and wide-ranging interests inspired many young researchers� Jane Lian, PhD, Prof University of Vermont, Larner College of Medicine Burlington, United States ECTS Fellowship Award Basic Fellowship Antonio Maurizi, PhD University of L’Aquila Department of Biotechnological and Applied Clinical Sciences L‘Aquilla, Italy Role of ER stress associated molecular network in the adaptation of dormant breast cancer cells in the bone micro-environment. Project Summary: The concept of natural selection, or adaptation, could be extended to tumour cells to describe their ability to spread and survive into a hostile environment� Tumor dormancy is one of the main adaptation mechanisms used by tumour cells to survive in a quiescent status for a long time due to temporary growth arrest� It could be considered a mechanism of adaptation to stress conditions, prompted for instance by chemotherapy or by the immune response, that gives a selective advantage to the metastatic cells� One of the cell stress mechanism described as a potential cell dormancy inducer is the Endoplasmic Reticulum stress (ER stress)� Our preliminary data suggest the presence of an ER stress associated molecular network in the dormant breast cancer cells lodging in the bone microenvironment� In this project, we hypothesized that the ER associated molecular network could induce dormant breast cancer cells to adapt and survive for a long time in the bone microenvironment� Moreover, it could be a potential targetable mechanism to prevent dormancy and eradicate breast cancer cells by chemotherapy, thus reducing the likelihood of their long-term reactivation and mobilisation� 8 ECTS 2020 Final Programme We expect this project could advance our understanding of the mechanisms that regulate the dormancy of breast cancer cells, allowing to identify innovative means to combat cancer relapse� Clinical Fellowship Awards Andreas Fontalis, MD MSc MRCS Academic Unit of Bone Metabolism, University of Sheffield Sheffield, United Kingdom Osteoclast precursors in patients treated with denosumab. Project Summary: Denosumab cessation is followed by a rapid decrease in BMD, raising concerns about a rebound phenomenon in bone turnover� It has been previously speculated that the long term sustained reduction in bone resorption beyond the end of treatment with bisphosphonates may be due to effects on the circulating osteoclast precursor cells� If in contrast, denosumab