Diagnosis, staging and treatment of patients with rectal cancer National Clinical Guideline - Draft guideline for consultation February 2020 1 This National Clinical Guideline has been developed by the National Cancer Control Programme Guideline Development Group, within the Health Service Executive (HSE). Using this National Clinical Guideline This National Clinical Guideline applies to adults (18 years or older) with newly diagnosed rectal cancer, or, those that have a suspected diagnosis of rectal cancer in a hospital setting. This guideline is intended for all health professionals involved in the diagnosis, staging and treatment of patients with rectal cancer. While the CEO, General Manager and the Clinical Director of the hospital have corporate responsibility for the implementation of the recommendations in this Clinical Guideline, each member of the multidisciplinary team is responsible for the implementation of the individual guideline recommendations relevant to their discipline. This guideline is also relevant to those involved in clinical governance, in both primary and secondary care, to help ensure that arrangements are in place to deliver appropriate care for the population covered by this guideline. Whilst the guideline is focused on clinical care, it is expected to be of interest to patients with rectal cancer and their significant others. Effort has been made to make this document more user friendly. A list of medical abbreviations used throughout the guideline can be found in Appendix 9: Glossary of terms and abbreviations. Disclaimer The Guideline Development Group’s expectation is that health professionals will use clinical knowledge and judgment in applying the principles and recommendations contained in this guideline. These recommendations may not be appropriate in all circumstances and it may be necessary to deviate from this guideline. Clinical judgment in such a decision must be clearly documented. Care options should be discussed with the patient, his/her significant other(s), and the multidisciplinary team on a case-by-case basis as necessary. 2 Membership of the Guideline Development Group The Guideline Development Group was chaired by Professor Deborah McNamara, Consultant Colorectal Surgeon, Beaumont Hospital. This National Clinical Guideline is supported by the National Cancer Control Programme (NCCP). Membership nominations were sought from a variety of clinical and non-clinical backgrounds so as to be representative of all key stakeholders within the Health Service Executive. Guideline Development Group members included those involved in clinical practice, research and librarian services, and health economics. The NCCP recognise the importance of patient input and their role as key stakeholders in informing quality improvements in our healthcare system. Patients were engaged via patients support & advocacy groups and charities and invited to contribute to the development of the guideline from a patient’s perspective. This approach assisted in capturing the patient experience which encompassed important quality of life issues and patients values. Name Title/Position Role on guideline group Professor Deborah Consultant Colorectal Surgeon, BH Chair and writing member McNamara Radiology Professor Martina Morrin Consultant Radiologist, BH Writing member Dr Marie Staunton Consultant Radiologist, MUH Writing member Dr Aoife McErlean Consultant Radiologist, BH Writing member (until October 2014) Dr Caitriona Logan Radiology Specialist Registrar, BH Writing member (until August 2019) Dr Stephen Power Radiology Specialist Registrar, CUH Writing member (until August 2019) Dr Nicola Hughes Radiology Specialist Registrar, CUH Writing member (until August 2019) Dr David Ryan Radiology Specialist Registrar, CUH Writing member (until August 2019) Dr David Woodlock Radiology Specialist Registrar, GUH Writing member (until August 2019) Dr Aileen O’Shea Radiology Specialist Registrar, BH Writing member (until August 2019) Dr Damien O’Neill Radiology Specialist Registrar, BH Writing member (until August 2019) Pathology Dr Michael Bennett Consultant Histopathologist, CUH Writing member Professor Elaine Kay Consultant Histopathologist, BH Writing member (until Oct 2019) Dr Cian Muldoon Consultant Histopathologist, SJH Writing member Professor Kieran Sheahan Consultant Histopathologist, SVUH Writing member 3 Name Title/Position Role on guideline group Gastroenterology Professor Padraic Consultant Gastroenterologist, MMUH Writing member MacMathuna Dr Martin Buckley Consultant Gastroenterologist, MUH Writing member Dr Subhasish Sengupta Consultant Gastroenterologist, OLOLH Writing member Dr Barbara Ryan Consultant Gastroenterologist, TUH Writing member Surgery Ms Eleanor Faul Consultant Colorectal Surgeon, OLOLH Writing member Ms Ann Hanly Consultant Colorectal Surgeon, SVUH Writing member Mr Eddie Myers Consultant Colorectal Surgeon, PH Writing member Mr Jurgen Mulsow Consultant Colorectal Surgeon, MMH Writing member (from October 2019) Mr John Burke Consultant Colorectal Surgeon, BH Writing member (from October 2019) Mr Emmet Andrews Consultant Colorectal Surgeon, BH Writing member (from October 2019) Mr Paul McCormick Consultant Colorectal Surgeon, SJH Writing member (from October 2019) Professor Fiachra Cooke Consultant Colorectal Surgeon, UHW Writing member (from October 2019) Professor Calvin Coffey Consultant Colorectal Surgeon, UL Writing member (from October 2019) Mr Myles Joyce Consultant Colorectal Surgeon, GUH Writing member (from October 2019) Professor Ronan O’ Connell Consultant Colorectal Surgeon, SVUH Writing member (from October 2019) Dr Gemma Solon Colorectal Specialist Registrar, MMUH Writing member (until October 2019) Dr Ailin Rogers General Surgery Specialist Registrar, BH Writing member (until October 2019) Dr Cillian Clancy General Surgery Specialist Registrar, MMUH Writing member (until October 2019) Dr Babak Meshkat General Surgery Specialist Registrar, BH Writing member (until October 2019) Radiation Oncology Dr Brian O’Neill Consultant Radiation Oncologist, SLRON Writing member Dr Cormac Small Consultant Radiation Oncologist, GUH Writing member Dr Charles Gillham Consultant Radiation Oncologist, SLRON Writing member Dr Martin Higgins Radiation Oncology SpR, SLRON Writing member (from October 2019) Dr Julianne O’ Shea Radiation Oncology SpR, SLRON Writing member (from November 2019) Dr Emma Connelly Radiation Oncology SpR, CUH Writing member (from November 2019) Dr Geraldine Murphy Radiation Oncology SpR, SLRON Writing member (from November 2019) 4 5 Name Title/Position Role on guideline group Palliative Care Dr Karen Ryan Consultant in Palliative Medicine & Clinical Writing member Lead Clinical Programme for Palliative Care, SFH Patient representative Groups Irish Cancer Society Patient representative Contributor Colorectal Cancer Group Mayo Stoma Support Group Patient representative Contributor Waterford Stoma Support Patient representative Contributor Group Southeast Ostomates Patient representative Contributor Project Management Ms Keira Doherty- Project Manager, NCCP Project manager & writing McCullough member (January 2017 - current) Ms Deirdre Love Project Manager, NCCP Project manager & writing member (from July 2014 – December 2016) Ms Angela Clayton-Lea Project Manager, NCCP Project manager & writing member (from December 2012 – May 2014) Research Dr Eve O’Toole Guideline Methodologist, NCCP Writing member/Methodology Chair Ms Louise Murphy Research Officer, NCCP Writing member/research Dr Helena Gibbons Senior Research Officer, NCCP Writing member/research (from September 2017) Dr Niamh Kilgallen Senior Research Officer, NCCP Contributor (from December 2017) Library Ms Margaret Morgan HSE Librarian, HSE East Information services Ms Maura Flynn HSE Librarian, HSE Midlands Information services Ms Nicola Fay HSE Librarian, HSE Midlands Information services Mr Gethin White HSE Librarian, HSE East Information services Mr Brendan Leen HSE Librarian, HSE South Information services Ms Marie Carrigan HSE Librarian, SLRON Information services Ms Helen Clarke HSE Librarian, SUH Information services Ms Anne Madden HSE Librarian, SVUH Information services Health Economist Ms Rebecca Moore Health Economist, TCD Health Economist & writing member 6 Key: BH Beaumont Hospital CUH Cork University Hospital MMUH The Mater Misericordiae University Hospital MUH Mayo University Hospital NCCP National Cancer Control Programme OLOLH Our Lady of Lourdes Hospital, Drogheda PH Portiuncula Hospital Ballinasloe SFH St. Francis Hospice SJH St. James’s Hospital SLRON St. Lukes Radiation Oncology Network SUH Sligo University Hospital SVUH St Vincents University Hospital TCD Trinity College Dublin TUH Tallaght University Hospital GUH Galway University Hospital UHW University Hospital Waterford UL University Hospital Limerick 7 Acknowledgments The following credits and acknowledgements are made by the Chair of the Guideline Development Group. The Chair, Professor Deborah McNamara wishes to acknowledge all members of the Guideline Development Group as full contributors credited with having given substantial intellectual leadership to the National Clinical Guideline. The Guideline Development Group clinical members, methodology chair, research members and project manager agreed the scope and developed the clinical questions. The Guideline Development Group librarians and research members carried out the systematic searches for evidence. The Guideline Development Group research members reviewed the evidence,