th J Cancer Allied Spec 2017;4(Supplement): 16 SK Cancer Symposium Poster Abstracts 001 P MORPHOLOGICAL TYPES OF PERI-AMPULLARY TUMOUR AT DIFFERENT DIAGNOSTIC MODALITIES AND ITS OUTCOME M.ATTAULLAH KHAN, IRFAN-UL-ISLAM NASIR, M. SHADAB KHAN, M. ASIF NOOR, ABDUL WAHID ANWAR, FAISAL HANIF SHAUKAT KHANUM MEMORIAL CANCER HOSPITAL & RC, LAHORE, PAKISTAN Background: Peri-ampullary tumour is a collective term used for different tumours at and around the ampulla of Vator. Sometime it is pretty confusing with pancreatic head tumour and a clear diagnosis is difficult at different imaging modalities. Objective: The aim of this study is to describe the morphology of different peri-ampullary tumours on different imaging modalities and to know its survival. Methodology: Record of 48 patients was retrieved who underwent pancreatico-duedenectomy in Shaukat Khanum hospital for different tumours of the ampullary region, from Jan 2012 till March 2017. Data was collected regarding patient and tumour characteristics on different imaging modalities and their survival. All the data was analysed in SPSS 20. Results: There were 43.5% male and 26.1% females, with mean age of 53. On Tri-phasic CT with liver protocols the most common findings were no mass (29%), followed by pancreatic head mass (18.8%) while on endoscopic ultrasound the most common findings were pancreatic head tumour (34.8%) and peri-ampullary (8.7%). On histopathology the most common tumour site was peri-ampullary (30.4%) and ampullary region tumours (18.8%). Most common tumour stage at EUS was T2N0 (21.7%) while on histopathology the most common tumour stage was T3N1 (31.9%). Most favourable survival was for ampullary cancer with average 637 days and the worst for pancreatic cancer with average survival of 249 days. Recurrence was most common in pancreatic (51%) followed periampullary cancer patients (39%). Conclusion: CT scan and EUS has limited sensitivity in terms of exact localization of different tumours at ampullary region which has prognostic implications as morphologically different tumours around the ampullary region has a significant difference in terms of survival and recurrence. JOURNAL OF CANCER & ALLIED SPECIALTIES 1 th J Cancer Allied Spec 2017;4(Supplement): 16 SK Cancer Symposium Poster Abstracts 002 P A REVIEW OF MANAGEMENT OF SUPERIOR MESENTERIC ARTERY SYNDROME AT TERTIARY CARE HOSPITAL AMYNA SHOUKAT ALI JIWANI DEPARTMENT OF SURGERY, AGA KHAN UNIVERSITY HOSPITAL, KARACHI, PAKISTAN Objective: Till date many researchers have doubted the existence of superior mesenteric artery syndrome as a real entity; it is believed that SMA syndrome is over diagnosed because it is confused with other causes of mega duodenum. Nonetheless, the entity is a well-known complication of scoliosis surgery, anorexia, and trauma. It often poses a diagnostic dilemma; its diagnosis is frequently one of exclusion. Therefore, this study is being done to explore different options for the management of SMA syndrome and to evaluate its effectiveness. Material and methods: This is case series of 9 cases conducted at AKUH from January 2007 to December 2015, study was analysed in SPSS version 21; these were then grouped in surgical and non-surgically managed patients. Categorical variables were calculated as percentages, continuous variables were calculated as mean and SD, p value of <0.005 was considered significant. Results: Overall 9 patients presented to our hospital with the mean age of 27.5 years and a mean BMI of 17.3. 7 patients were males while 2 were females. 4 of them were managed conservatively while 5 underwent surgery. Presenting symptoms remained largely the same with abdominal pain and vomiting being the primary complains. Mean CT aortomesenteric angle was 13.53 and mean aortomesenteric distance was 9.75m. Mean Length of stay was 9 days. Mean weight gain after conservative management was 8.6kgs while in the surgical patients was 11.6kgs. There were 2 mortalities, one from each group. Overall there were no statistically significant different outcomes between the two groups. Conclusion: The diagnosis of duodenal obstruction is made with CT scan with oral contrast and may demonstrate dilatation of the proximal duodenum with failure of contrast passage beyond the third part of the duodenum with a cut off. Fluid resuscitation, bowel rest, TPN, and enteric feeding with a nasojejunal tube inserted past the obstruction is the conservative way to go about it. While surgical options include gastrojejunostomy, duodenojejunostomy and strongs procedure. In children and in adults with a short history, conservative approach may have a reasonable prospect of success, but in the chronic adult patient, it is often a prolonged in-hospital therapy with a low success rate. JOURNAL OF CANCER & ALLIED SPECIALTIES 2 th J Cancer Allied Spec 2017;4(Supplement): 16 SK Cancer Symposium Poster Abstracts 003 P RISK OF SURGICAL SITE INFECTION IN PATIENTS HAVING POST-OPERATIVE HYPERGLYCEMIA AS COMPARED TO POST-OPERATIVE NORMOGLYCEMIC PATIENTS UNDERGOING ABDOMINAL SURGERY AMYNA SHOUKAT ALI JIWANI DEPARTMENT OF SURGERY, AGA KHAN UNIVERSITY HOSPITAL, KARACHI, PAKISTAN Surgical site infection is one of the common complications after major surgery. Several risk factors have been studied in detail and among them; post-operative hyperglycaemia is one of the independent risk factor. As there is no local data available, so we decided to do the study with following objective: Objectives: To estimate risk of surgical site infection in patients who had post-operative hyperglycaemia as compared to those who had optimum post-operative glycaemic control after abdominal surgery. Materials and methods: This is the prospective cohort study conducted at Aga Khan University Hospital. This included patients who underwent Exploratory Laparotomy (Complying the inclusion criteria) from Feb 1, 2016 till August 31, 2016 and those who underwent Emergency Laparotomy were excluded. A designed performa was made to collect the data. Sample size was calculated via WHO software and it turned out to be 66 in each group. Both the groups (with post-operative normoglycemia and hyperglycemia) were compared. SPSS v 20 was used for data entry and analysis. Results: Multiple variables were studied in this study but only ASA level has statistically significant association with post-operative SSI. Conclusion: ASA level is an independent risk factor for SSI in post-operative period and no statistically significant association is established between deranged reflos and SSI. JOURNAL OF CANCER & ALLIED SPECIALTIES 3 th J Cancer Allied Spec 2017;4(Supplement): 16 SK Cancer Symposium Poster Abstracts 004 P CHONDROSARCOMA: A REVIEW ON DIFFERENT MANAGEMENT OPTIONS, THE OUTCOMES AND THE FREQUENCY OF RECURRENCES KIRAN ABBAS, AMBER TAHIR SIDDQUI 1 JINNAH SINDH MEDICAL UNIVERSITY, 2 DOW UNIVERSITY OF HEALTH SCIENCES, KARACHI, PAKISTAN Chondrosarcoma is a rare malignant tumour of the cartilage that comprises of about 30% of all bone tumours. It usually affects older adults of age 35-40. It is a slow-growing tumour which gives the doctors ample amount of time to come up with an effective course of treatment. Prognosis of chondrosarcoma depends on the grading, size and the location of the tumour. According to WHO, survival rate for patients with Grade 1 chondrosarcoma is 89%. The combined group of patients with grade 2 and 3 has a five-year survival of 53%. The review aims to analyse the different management options adopted by the surgeons globally and the different outcomes/prognosis they yielded. It also aims to assess the frequency of local recurrence and treatment measures adapted by surgeons to reduce recurrence in their patients. JOURNAL OF CANCER & ALLIED SPECIALTIES 4 th J Cancer Allied Spec 2017;4(Supplement): 16 SK Cancer Symposium Poster Abstracts 005 P LASER INTERSTIAL THERAML THEAPY FOR BRAIN TUMOURS ASIM MAHMOOD HENRY FORD HOSPITAL, DETROIT, USA JOURNAL OF CANCER & ALLIED SPECIALTIES 5 th J Cancer Allied Spec 2017;4(Supplement): 16 SK Cancer Symposium Poster Abstracts 006 P COMPARISION OF TOUCH PREPARATION CYTOLOGY AND FROZEN SECTION FOR INTRAOPERATIVE DIAGNOSIS OF SENTINAL LYMPH NODE METASTASES IN BREAST CANCER: SAMREEN NAZ, 2ANWAR KAMAL, 3HUMAIRA ERUM, 4ATIF ALI HASHMI, 5NAVEEN FARIDI DEPARTMENT OF HISTOPATHOLOGY AND CYTOLOGY, LIAQUAT NATIONAL HOSPITAL AND MEDICAL COLLEGE, KARACHI. Introduction: Accurate analysis of Touch Preparation (TP) Cytology for intraoperative diagnosis of sentinel lymph node (SLN) Metastases can avoid unnecessary axillary lymph node dissection. Frozen Section is the most popular method for intraoperative SLN diagnosis. Touch preparation Cytology has also been suggested as less expensive and rapid diagnostic tool. Moreover it provides clear cytologic details and allows examination of multiple cut surfaces at one time and preserving the tissue for permanent paraffin sectioning. Objective: The aim of this study is to compare the accuracy of Touch Preparation Cytology and Frozen Section for the intraoperative diagnosis of Sentinel Lymph node Metastases in breast cancer. Material & methods: A prospective study is performed during September 2016 - May 2017 in Department of Histopathology and Cytology, Liaquat National Hospital and Medical College Karachi. 114 patients were included who underwent Sentinel LN dissection. All SLNs were sectioned at 2mm intervals. TP were made from all cut surfaces after which all sections were examined for frozen sections. Results of both Touch Preparation Cytology and Frozen Section were compared with final paraffin diagnosis. Results: In a total of 114 patients, the mean age was 53 years, age range (25-83) and the mean size of SLN was 0.4 cm, size range (0-4) cm. The sensitivity, specificity and accuracy were 83.7%, 98.5% and 92.1%, respectively, for TP and 93.9%, 100% and 97.3% for FS. Conclusion: Intraoperative Touch Preparation Cytology is a useful method for evaluating axillary lymph node metastases in patients with breast cancer. Touch preparation cytology is marginally less sensitive but it is more cost effective and rapid diagnostic method than Frozen Section diagnosis. Hence, Touch Preparation Cytology can be used as alternative where frozen section facility is not available.