#28.2 The worldwide journal for the companion animal veterinarian 2018 - $10 / 10€ GENETICS AND HEALTH Maintaining genetic diversity: why it matters - Casey A. Knox and Katherine M. Lytle - P02 Clinical applications of genetic testing - Jamie L. Freyer and Angela Hughes - P08 The ABCB1 gene in dogs - Cynthia Cole - P14 Copper-associated hepatitis in dogs - Hille Fieten - P16 How I approach… Perianal fistula disease in dogs - Lindsay W. McKay - P21 The Tom and Jerry Syndrome - Mark Lowrie and Laurent Garosi - P27 Hereditary erythrocyte disorders - Urs Giger - P32 Liquid biopsy – the future for cancer diagnostics? - Matthew Breen and Claire Wiley - P39 Breed predispositions for urolithiasis - Doreen M. Houston and Anne-Marie Germain - P46 FIND YOUR MAGAZINE ONLINE #27.3e 2017 – $10/10 TAKE A COMPLETE The worldwide journal for the companion animal veterinarian NUTRITIONAL APPROACH #28.1 2018 - $10 / 10€ TO ALLERGIC DERMATITIS The worldwide journal for the companion animal veterinarian CANINE#28.2 AND FELINE DERMATOLOGY2018 - $10 / 10€ - Catherine D. Milley - P02 The worldwide journal for the companion animal veterinarianFeline miliary dermatitis - P08 How I approach…- Rosanna Canine Marsella ® pododermatitis Only the ROYAL CANIN Dermatological Pemphigus foliaceus in feline patients DISEASE AND- Christoph J. Klinger and Ralf S. Mueller - P15 Anti-inflammatory and anti-pruritic - SmallGENETICS dogstherapy in– canine big atopy problems range offers the choice of extensively- The small dog trend: impact of size- Debbie on petGow healthand Tim Nuttall• Legg-Calvé-Perthes - P20 Disease in dogs • Brachycephaly- - related diseases • Canine hydrocephalusDermatological • Chiari-like features malformation of canine and leishmaniasis syringomyelia • Paroxysmal gluten- sensitiveMaintaining dyskinesia genetic in Border diversity: Terriers why • Texture it matters analysis of wet petfood • Dental disease in small-breed dogs - Laura Ordeix and Xavier Roura - P22 Casey A. Knox and Katherine M. Lytle - P02 - P08 - Patricia D. White - P30 Clinical applications ofCutaneous genetic- testing manifestations of hydrolysed and partially-hydrolysed protein- Jamie L. Freyer and Angela Hughessystemic disease - The ABCB1 gene in Eliminationdogs - Vandre diet Clear trials: - P38 setting up for Cynthia Cole - P14 success - Copper-associated Qualityhepatitis control in dogs for hydrolyzed diets based diets for cats and dogs, allowing you Hille Fieten - P16 - Isabelle Lesponne and Jerôme Naar - P40- Elizabeth Goodale - P42 - How I approach… PerianalVascular fistula disease skin in diseasedogs Lindsay W. Mckay - P21 - The Tom and Jerry Syndrome to choose the level of hypoallergenicity. Mark Lowrie and Laurent Garosi - P27 Hereditary erythrocyte disorders Urs Giger - P32 - - Liquid biopsy – the -future P39 for cancer diagnostics? From diagnosis to long-term management, Matthew Breen and Claire Wiley Breed predispositions for urolithiasis Doreen M. Houston and Anne-Marie Germain - P46 now there is a diet for every stage of your clinical approach. Our ANALLERGENIC product is your first http://vetfocus.royalcanin.com/ choice for elimination diet trials for Adverse Food Reaction (AFR) or diagnosing Atopy by exclusion. NEW The worldwide journal for the companion animal veterinarian #28.3 COMING UP... In our next issue of Veterinary Focus, we will look at different aspects of nutrition: ■■ Feline feeding behavior ■■ Drinking behavior in cats Jon Bowen, UK Stefanie Handl, Austria ■■ Dog breeds and their ■■ Grain-free diets – good or influence on food-related bad? diseases Maryanne Murphy, USA Shutterstock Shutterstock Giacomo Biagi, Italy ■■ The benefits of feeding ■■ The Lewisburg Pet Health wet diets and Nutrition Center (PHNC) Megan Shepherd and Jessica Sally Perea, USA Benson, USA ■■ The role of Vitamin D in canine disease Valerie Parker, USA ■■ Dietary considerations for dogs with chronic enteropathies Shutterstock Shutterstock Adam Rudinsky, USA SAS 2018. All rights reserved. rights All 2018. SAS ® We welcome offers to write ideas for papers and suggestions for topics and authors, which should be directed to the editor. Veterinary Focus is fully covered by copyright. No part of this publication may be reproduced, copied or transmitted in any form or by any means (including graphic, electronic or mechanical), without the written consent of the publishers © Royal Canin SAS 2018. Proprietary names (trademarks) have not been specially identified. It cannot, however, be conducted from the omission of such information that they are non-proprietary names and as such can be used by everyone. The publishers cannot take any responsibility for information provided on dosages and methods of application. Details of this kind must be checked for correctness by the individual user in the appropriate literature. While every CANIN ROYAL © effort has been made by the translators to ensure the accuracy of their translations, no responsibility for the correctness of the original articles and thus no resulting claims against professional negligence can be accepted in this connection. Views expressed by authors or contributors do not necessarily reflect the views of the publishers, editors or editorial advisors. RC-INT-AP DERMATO-MAF-210x275-1.indd 1 13/02/2018 11:17 Editorial VARIETY IS THE SPICE OF LIFE “When a man is tired of London, he is tired of life” So said Samuel Johnson, the renowned 18th century essayist, moralist and critic, a man who appreciated diversity and believed that the city offered almost unlimited opportunities for novel entertainment, stimulating dialogue and motivating challenges. He was essentially expressing the idea that everyone likes variety, and he was surely right. We would all concur with the sentiment that variety is the spice of life, and things would be very boring if we were all the same. And so it is with our pets – some people like the long ears of a Bassett, others are drawn to the prick ears of a Corgi; some admire the sleek coat of a Siamese, whilst others prefer the long hair of a Norwegian or the distinctive markings of an Egyptian Mau. And as every veterinarian knows, when breeding for certain features – whether that is ear shape, coat color or facial contours – it is possible to inadvertently introduce unwanted characteristics at the same time. But keeping up with the diversity of breed problems can be a challenge in itself. Dr. Johnson also said “Knowledge is of two kinds. We know a subject ourselves, or we know where we can find information upon it” and Veterinary Focus offers clinicians the latter, addressing as it does some of the breed-related issues that are to be found in our patients today. Ewan McNEILL Editor-in-chief Focus on Veterinary Focus A mutation in the canine ABCB1 p32 gene results in affected animals Perianal fistula disease has being unusually sensitive to many a suggested multifactorial Several hereditary different drugs commonly etiology, including immune erythrocyte defects have used within veterinary been reported in dogs and practice, and clinical signs dysfunction, food allergy and a cats, but such disorders of toxicity can occur when genetic predisposition for German are often only considered normally therapeutic doses are administered to Shepherd dogs. after speculative treatments dogs with one or two for immune and infectious copies of the mutation. p21 causes of anemia have p14 failed. Editorial committee Translation control Veterinary Focus is published in not been specially identified. It cannot, veterinary • Craig Datz, DVM, Dipl. ACVN, • Elisabeth Landes, DVM (German) Brazilian Portuguese, Chinese, however, be conducted from the omission Senior Scientific Affairs Manager, • Noemí Del Castillo, PhD (Spanish) English, French, German, Italian, of such information that they are non- Royal Canin, USA • Matthias Ma, DVM (Chinese) Japanese, Polish, Russian & Spanish. proprietary names and as such can be #28.2 • Pauline Devlin, BSc, PhD, • Minoru Fukuyama, DVM (Japanese) used by everyone. The publishers cannot Scientific Communications and • Boris Shulyak, PhD (Russian) Find the most recent issues on: http:// take any responsibility for information External Affairs, Royal Canin, UK vetfocus.royalcanin.com and www.ivis.org. provided on dosages and methods of • María Elena Fernández, DVM, Chile Deputy publisher: Buena Media Plus application. Details of this kind must be • Philippe Marniquet, DVM, Dipl. ESSEC, Bernardo Gallitelli and Didier Olivreau The licensing arrangements for therapeutic checked for correctness by the individual Veterinarian Prescribers Marketing 90, rue de Paris 92100 Boulogne- agents intended for use in small animal user in the appropriate literature. While Manager, Royal Canin, France Billancourt, France species vary greatly worldwide. In the every effort has been made by the • Brunella Marra, DVM, Scientific Phone: +33 (0) 1 72 44 62 00 absence of a specific license, consideration translators to ensure the accuracy of Origine du papier : VIRTON (Belgique) Communication and Scientific Affairs should be given to issuing an appropriate their translations, no responsibility for Taux de fibres recyclés : 0% Manager, Royal Canin, Italy Editor-in-chief: Ewan McNeill, BVMS, cautionary warning prior to administration the correctness of the original articles Certification : 100% PEFC • Sally Perea, DVM, Dipl. ACVN, Cert VR, MRCVS of any such drug. and thus no resulting claims against Impact sur l’eau : 0.012 P tot kg/tonne Nutritionist, Royal Canin, USA Editorial secretary professional negligence