Outputs, outcomes and impact of MRC research 2014/15 report European Union (EU) Scale: 1 Collaboration ISBN 978-0-903730-22-8 © Medical Research Council copyright 2016 You may re-use this information (excluding logos, images and icons) free of charge in any format or medium, under the terms of the Open Government Licence. To view this licence, visit http://www.nationalarchives.gov.uk/doc/open-government-licence/ or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or e-mail: [email protected] When providing a citation for this document we recommend the following: Medical Research Council (2016) MRC Outputs, outcomes and impact of MRC research 2014/15 report. Publisher: Medical Research Council, London, UK. ISBN: 978-0-903730-22-8 Any enquiries related to this publication should be sent to us at: Medical Research Council, 14th Floor, One Kemble Street, London WC2B 4AN or [email protected] This publication is available at https://www.mrc.ac.uk/successes/outputs-report/ Table of Contents List of case studies by primary output type 3 SECTION 1.0: Introduction 7 Overview 9 Key 11 researchfish® 12 SECTION 2.0: Case studies 15 2.1: Published research 17 2.2: Policy and engagement 37 2.3: Development of products and intellectual property 65 2.4: Research materials 107 2.5: Industry interactions and other collaborations 135 2.6: Awards and recognition 165 SECTION 3: Quantitative analysis 179 3.1 Publications 181 3.2: Collaborations 186 3.3 Further funding 191 3.4 Next destination 198 3.5 Engagement activities 201 3.6 Influence on policy 205 3.7 Research materials – tools and methods, databases and models 210 3.8 Intellectual property 215 3.9 Products and interventions 219 3.10 Awards and recognition 225 Front cover image credits Mosquito on human skin at sunset. Image credit: Shutterstock | Ebola workers in Liberia. Image credit: Flickr/European Commission DG ECHO CC BY 3.0 | An image from the BoneFinder software. Image credit: Claudia Lindner, University of Manchester | Back of the eye showing intermediate age-related macular degeneration. Image credit: National Eye Institute, National Institutes of Health | Bacteriophage. Image credit: BlueSci. Cambridge University science magazine | Niall Kent. Image credit: Niall Kent, UCL Outputs, outcomes and impact of MRC research: 2014/15 report 1 2 Outputs, outcomes and impact of MRC research: 2014/15 report List of case studies by primary output type Publications » Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. page 24 » MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial ....................................page 25 » An integrated map of genetic variation from 1,092 human genomes ..................................page 25 » Clinical and biomarker changes in dominantly inherited Alzheimer’s disease ............................page 26 » Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. .page 27 » A molecular marker of artemisinin-resistant Plasmodium falciparum malaria ...........................page 27 » Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis ..............................................................page 28 » Schizophrenia Working Group of the Psychiatric Genomics Consortium Biological insights from 108 schizophrenia-associated genetic loci ......................................................page 29 Collaborations » NeuroStemCell ...................................................................................page 141 » Uncovering how fever stimulates HIV replication ....................................................page 150 » Drug safety .......................................................................................page 151 » Smartphone app to monitor musculoskeletal disease ................................................page 153 » Developing drugs to treat liver fibrosis ..............................................................page 154 » Mechanisms in fatty liver disease ..................................................................page 155 » Thrombolytic treatment soon after stroke reduces risk of disability. .page 156 » Medicines for Malaria Venture .....................................................................page 158 » The Clinical Trials Transformation Initiative (CTTI) ...................................................page 159 Further funding » Bacteria-eating viruses ............................................................................page 143 » Developing treatments for and harnessing the potential of Clostridia .................................page 143 » Epigenetics in Alzheimer’s disease ..................................................................page 147 » Understanding the immune response in Crohn’s disease .............................................page 149 » Economic evaluation of healthcare technologies ....................................................page 153 Outputs, outcomes and impact of MRC research: 2014/15 report 3 Engagement activities » Functional genome ................................................................................page 43 » Antimicrobial resistance media coverage ............................................................page 47 » Edinburgh Fringe Festival. page 49 » Muscular Dystrophy Campaign (MDC) Duchenne and Becker impact day ..............................page 50 » The secret life of four-year olds .....................................................................page 51 » Role of the habenula in negativity ...................................................................page 52 » Expert commentary on healthy diet. page 54 » Alcohol consumption in pregnancy .................................................................page 55 Influence on policy » Reports on Ebola to the World Health Organization and other international stakeholders ...............page 40 » International rabies strategies ......................................................................page 41 » Setting WHO post-2015 global tuberculosis targets ...................................................page 42 » NICE guidelines on Hypertension: Clinical management of primary hypertension in adults ..............page 44 » American Heart Association guidelines for arteriovenous malformations of the brain ...................page 45 » NICE guidelines on Eculizumab for treating atypical haemolytic uraemic syndrome (aHUS). .page 46 » Participation in Acting on Campylobacter Together (ACT) campaign ..................................page 48 » Co-author of 2014 Chief Medical Officer (CMO) annual report on public mental health .................page 51 » NICE guidelines on Managing overweight and obesity in adults – lifestyle weight management services. .page 52 » Citations in public health guidelines on physical activity ..............................................page 53 » Smoking reduction .................................................................................page 56 » Expert witness to Commission on Hearing Loss ......................................................page 57 Research tools and methods » Screening device to predict how patients will respond to leukaemia chemotherapy ...................page 111 » Genetically-modified cell line to repair damaged nerve ..............................................page 112 » Device to monitor antibiotic effectiveness .........................................................page 114 » Mice with deleted immune cells ...................................................................page 114 » Cell line to help investigate the regulation of an immune system process .............................page 115 » Eye tissue repository ..............................................................................page 116 » Mouse model with gene mutation affecting metabolism ............................................page 119 » MRI protocol to investigate brain health ............................................................page 120 » Brain and spinal cord tissue ........................................................................page 121 » Drosophila model of neurodegeneration ...........................................................page 122 » Detecting asymptomatic malaria infections .........................................................page 124 » Rabbit model of cryptococcal meningitis ...........................................................page 125 » Tools to detect genome-wide DNA damage and repair ..............................................page 126 » Simulation model for prostate cancer ..............................................................page 128 » Platform to predict effective drug combinations ....................................................page 129 4 Outputs, outcomes and impact of MRC research: 2014/15 report Research databases and models » Mathematical model of anti-virulence drugs to treat bacterial infections .............................page 113 » UK Primary Sjögren’s Syndrome Registry (UKPSSR) ..................................................page 115 » Database of HIV patients ..........................................................................page 118 » The Twins Early Development Study (TEDS) dataset .................................................page 123 » International Mouse Phenotyping