JOURNAL OF OPIOID MANAGEMENT OPIOID OF JOURNAL Journal of Opioid ManagementTM A medical journal for proper and adequate use Volume 3, Number 1 JANUARY/FEBRUARY 2007 ISSN 1551-7489 Official Journal of Opioid Management Society CONTENTS n GUEST EDITORIAL Patterns of illicit drug use and retention in a Can we continue to do business as usual? . 5 methadone program: A longitudinal study. 27 B. Eliot Cole, MD, MPA Ingrid Davstad, MA Marlene Stenbacka, PhD n OPIOID NEWS AND EVENTS Anders Leifman, MSE Calendar . 8 Olof Beck, PhD News briefs . 9 Seher Korkmaz, MD, PhD Anders Romelsjö, MD, PhD n PHARMACY PERSPECTIVE A randomized, open-label, multicenter trial Opioid administration for acute abdominal comparing once-a-day AVINZA® (morphine JANUARY/FEBRUARY 2007 pain in the pediatric emergency department . 11 sulfate extended-release capsules) versus twice- Adi Klein-Kremer, MD a-day OxyContin® (oxycodone hydrochloride Ran D. Goldman, MD controlled-release tablets) for the treatment of chronic, moderate to severe low back pain: n LEGAL PERSPECTIVE Improved physical functioning in the ACTION trial . 35 Medicolegal rounds: Medicolegal issues and alleged breaches of standards of medical care Richard L. Rauck, MD in a patient motor vehicle accident allegedly Stephen A. Bookbinder, MD related to chronic opioid analgesic therapy . 16 Timothy R. Bunker, MD Christopher D. Alftine, MD David A. Fishbain, MD, FAPA Steven Gershon, MD John E. Lewis, PhD Egbert de Jong, MD Brandly Cole, PsyD Andres Negro-Vilar, MD, PhD Renné Steele Rosomoff, BSN, MBA Richard Ghalie, MD Hubert L. Rosomoff, MD, DMedSc, FAAPM n LITERATURE REVIEWS n ORIGINAL ARTICLES Buprenorphine: A unique opioid with broad Morphine prescription in end-of-life care and clinical applications . 49 euthanasia: French home nurses’ opinions . 21 Nalini Vadivelu, MD; Roberta L. Hines, MD Marc Karim Bendiane, PhDc Anne-Deborah Bouhnik, PhDc Developmental pharmacokinetics of opioids Roger Favre, PhD in neonates. 59 VOL. 3, NO. 1: 1-64 1: NO. 3, VOL. Anne Galinier, MD Karel Allegaert, MD, PhD Yolande Obadia, MD Sinno H. Simons, MD, PhD Jean-Paul Moatti, PhD Christine Vanhole, MD, PhD Patrick Peretti-Watel, PhD Dick Tibboel, MD, PhD Journal of Opioid Management TM A medical journal for proper and adequate use 470 Boston Post Road • Weston, MA 02493 781-899-2702 • Fax: 781-899-4900 E-mail: [email protected] Journal of Opioid ManagementTM A medical journal for proper and adequate use Published bimonthly by Prime National Publishing Corporation 470 Boston Post Rd., Weston, MA 02493 • 781-899-2702, Fax: 781-899-4900 www.opioidmanagement.com E-mail: [email protected] President, Executive Publisher, Vice President Editor-in-Chief Acquisitions Editor Managing Editor Advertising Manager Robert E. Enck, MD Christopher V. Rowland, Jr., MD Eileen F. DeVito Richard A. 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However, the publisher and editors accept no liability whatsoever for the consequences of any inaccurate or misleading data, opinion, or statement. Copyright 2007. Quotation is not permitted except as above. Duplicating an entire issue for sharing with others, by any means, is illegal. Photocopying of individual items for internal use is permitted for registrants with the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923. For details, call 978-750-8400 or visit www.copyright.com. Since 2005, this journal has been printed on acid-free paper that meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper). 12576 1/22/07 Rev. h Journal of Opioid ManagementTM A medical journal for proper and adequate use Editor-in-Chief, Robert E. Enck, MD Professor of Medicine, Assistant Division Chief for Clinical Activities, Division of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania. Editorial Review Board Linda Gibbs Alley, PhD, RN Michael Camilleri, MD Frederick J. Goldstein, PhD, FCP Epidemiologist, Cancer Surveillance Branch, Professor of Physiology and Medicine, Professor of Clinical Pharmacology, Division of Cancer Prevention and Control, Mayo Clinic College of Medicine, Coordinator of Pharmacology, Philadelphia Centers for Disease Control and Prevention, Rochester, Minnesota. College of Osteopathic Medicine, Atlanta, Georgia. Philadelphia, Pennsylvania. Michael E. Clark, PhD Lainie Andrew, PhD, MA Clinical Director, Chronic Pain Rehabilitation Jose Antonio Saraiva Ferraz Goncalves, Pain Psychologist, Craniofacial Pain Center, Program, James A. Haley Veterans Hospital, MD, Medical Director, Palliative Care Unit, and Clinical Assistant Professor, Tufts Dental Tampa, Florida. Portuguese Institute of Oncology, Porto, Portugal. School, Boston, Massachusetts. Mellar P. Davis, MD, FCCP Gregory Paul Gramelspacher, MD Antonios Andronikou, PhD Medical Director, The Harry R. Horvitz Center Associate Professor of Medicine, Indiana Executive Director, The Cyprus Anti-Cancer for Palliative Medicine, Cleveland Clinic University School of Medicine, Society, Strovolos, Cyprus. Taussig Cancer Center, Cleveland, Ohio. Bloomington, Indiana. Robert L. Barkin, MBA, PharmD, FCP, Franco De Conno, MD, FRCP Carmen Renee Green, MD DAAPM, Associate Professor, Departments Director, National Cancer Institute of Milan Associate Professor, Department of of Anesthesiology, Family Medicine, Pharm- Division of Rehabilitation, Milan, Italy. Anesthesiology, University of Michigan acology, and Psychology, Rush University Health System, Ann Arbor, Michigan. Medical Center, Chicago, Illinois. Erin A. Egan, MD, JD Clinical Instructor, Neiswanger Institute for Daniel L. Handel, MD Steven J. Baumrucker, MD, FAAFP, Bioethics and Health Policy, Loyola University Staff Clinician, Pain and Palliative Care FAAHPM, Medical Director, Holston Medical Center, Maywood, Illinois. Service, National Institutes of Health, Valley Palliative Care, Wellmont Health Bethesda, Maryland. System; Medical Director, Palliative Robert E. Enck, MD Medicine Associates; Medical Director, Professor of Medicine, Assistant Division Chief Craig T. Hartrick, MD, DABPM, FIPP Adventa Hospice; Assistant Clinical for Clinical Activities, Division of Medical Anesthesiology Research, William Beaumont Professor, ETSU College of Medicine, Oncology, Thomas Jefferson University, Hospital, Royal Oak, Michigan. Kingsport, Tennessee. Philadelphia, Pennsylvania. Christopher M. Herndon, PharmD, David M. Benjamin, PhD, MS Gilbert J. Fanciullo, MD BCPS, Senior Scientific Liaison, Division Clinical Pharmacologist and Toxicologist, Associate Professor of Anesthesiology, Pain of Clinical Affairs, Ortho-McNeil Pharma- Chestnut Hill, Massachusetts. Management Center, Dartmouth-Hitchcock ceutical, O’Fallon, Illinois. Medical Center, Lebanon, New Hampshire. Ramsin M. Benyamin, MD, DABPM, Bruce P. Himelstein, MD FIPP, President, Millennium Pain Center, Kathleen W.