SCIENCE CITATIONINDEXINDEXED MEDICUS INDEX BY (MEDLINE) EXPANDED (ISI) OFFICIAL JOURNAL OF THE SOCIETÀ ITALIANA DI DERMATOLOGIA MEDICA, CHIRURGICA, ESTETICA E DELLE MALATTIE SESSUALMENTE TRASMESSE (SIDeMaST) VOLUME 149 - No. 1 - FEBRUARY 2014 Anno: 2014 Lavoro: 4731-MD Mese: Febraury titolo breve: Hair loss in infancy Volume: 149 primo autore: MORENO-ROMERO No: 1 pagine: 55-78 Rivista: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA Cod Rivista: G ITAL DERMATOL VENEREOL G ITAL DERMATOL VENEREOL 2014;149:55-78 Hair loss in infancy J. A. MORENO-ROMERO 1, R. GRIMALT 2 Hair diseases represent a signifcant portion of cases seen 1Department of Dermatology by pediatric dermatologists although hair has always been Hospital General de Catalunya, Barcelona, Spain a secondary aspect in pediatricians and dermatologists 2Universitat de Barcelona training, on the erroneous basis that there is not much in- Universitat Internacional de Catalunya, Barcelona, Spain formation extractable from it. Dermatologists are in the enviable situation of being able to study many disorders with simple diagnostic techniques. The hair is easily ac- cessible to examination but, paradoxically, this approach is often disregarded by non-dermatologist. This paper has Embryology and normal hair development been written on the purpose of trying to serve in the diag- nostic process of daily practice, and trying to help, for ex- ample, to distinguish between certain acquired and some The full complement of hair follicles is present genetically determined hair diseases. We will focus on all at birth and no new hair follicles develop thereafter. the data that can be obtained from our patients’ hair and Each follicle is capable of producing three different try to help on using the messages given by hair for each types of hair: lanugo, vellus and terminal. Lanugo patient. Quite often it is extremely hard to distinguish between abnormality and normality in neonatal hair as- hairs are the neonatal non-pigmented, soft, fne hairs pects. We will specially focus in the most common physi- with no central medulla; vellus hairs are short, fne, ological changes that may mislead to an incorrect diagno- lightly pigmented and they are the hairs found over sis. Specifc treatment for those hair diseases that do have much of the adult body; terminal hairs are the long, one, and basic general approach to improve the cosmetic thick, strongly pigmented hairs found in the scalp appearance of hair, will be also be discussed for those hair disturbances that do not have a specifc treatment. and eyebrows of adults and children, as well as the Key words: Child - Alopecia - Hair diseases. axillary and pubic areas of adults and the chest and facial areas of adult males.1 Hair development begins in utero at 9th week, with air loss in children encompasses a wide range of the follicular units composed of epidermally derived Hconditions that can be congenital or acquired. A follicles and mesodermally derived papillae. Primary congenital hair abnormality may be an isolated fnd- hair follicles frst develop on the eyebrows, upper lip ing in an otherwise healthy child or may exist as a and chin. Later, hair follicles develop over the scalp feature of a clinical syndrome. The clinical presenta- in a frontal to occipital direction and over the body in tion of pediatric hair disorders ranges from subtle to a cephalocaudal direction. Secondary follicles then disfguring. A basic working knowledge of normal form at each side of the primary follicles, producing hair growth is necessary, including the embryology typical groups of three hairs on follicular units (Mei- and development of the hair. jeres trios). At 16 weeks of gestation, hair production begins in the follicles. All follicles produce lanugo 2 Corresponding author: J. A. Moreno-Romero, Department of Derma- hair that grows 2-3 cm in length. Fine lanugo hair tology, Hospital General de Catalunya, Barcelona, Spain. covers the scalp and proceeds to appear elsewhere Vol. 149 - No. 1 GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA 55 MORENO-ROMERO HAIR LOSS IN INFANCY Figure 2.—Alopecia areata may involve hair and nails. months until the age of 2 years. This hair is coarser than lanugo hairs, but still are sparsely pigmented.6 At full term, there are two consecutive waves of hair on the scalp, each running from forehead to oc- ciput. Toward the end of the frst year of live, follow- ing the frst two synchronized waves of telogen, there Figure 1.—Transient neonatal hair loss (TNHL). In many cases this physiological condition is confused with a frictional alopecia. is a transition to a random mosaic pattern where each hair has its own intrinsic rhythm. This asynchrony continues throughout life unless modifed by preg- in a cephalocaudal direction, eventually covering nancy or illness. the entire fetus. This constitutes the frst anagen At puberty, the level of circulating adrenal andro- (growth) wave. At 26-28 weeks of gestation, the gens increases and elicits a site-specifc response body and most of the scalp hair follicles enter cata- from the hair follicles. On the scalp, hairs miniatur- gen and subsequently telogen in a programmed wave ize in response to androgens; however, the hairs of in a cephalocaudal direction in the body and a fron- the body enlarge, with the hairs of the axillary, pubic, tal to parietal direction on the scalp. Most of these chest and beard regions being more responsive. The telogen hairs are shed in utero,3 although this can be hair of these regions change from vellus to terminal delayed until after birth. A band-like area of occipi- hair, contributing to the development of the second- tal hair does not enter telogen until 8-12 weeks after ary sex characteristics.1 birth. These occipital hairs fall out, producing a well Hair leaves the scalp at precisely formed angles. Dis- defned area of alopecia, known as occipital alopecia placement of the scalp line occurs in a number of syn- of the newborn, seen at around 4-8 months of age.4 It dromes. A congenitally high anterior hairline is seen in has been recently renamed as transient neonatal hair myotonic dystrophy. A congenitally low posterior hair- loss (TNHL) (Figure 1).5 The duration of growth of line can occur in Turner and Noonan syndromes. A con- the scalp hairs extends, while that of the body hairs genitally low anterior hairline is found in Cornelia de shortens to produce hairs of 1 cm in length. These Lange syndrome, lipoatrophic diabetes, fetal hidantoin second body hairs grow for 4-8 weeks, then enter syndrome and Rubinstein-Taybi syndrome.6 telogen, and are shed during the frst 3-4 months of life to be replaced by a third coat of hair. Body hair progressively shorten into vellus hair, most of which Alopecia areata do not protrude from the follicle. Scalp hair enlarg- es progressively with each hair cycle into terminal Alopecia areata (AA) is a non-scarring, autoim- hair. Some infants display intermediate hair from 3 mune, infammatory, hair loss on the scalp and/or 56 GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA Febraury 2014 HAIR LOSS IN INFANCY MORENO-ROMERO body. Recognized subgroups of this disease include those patients with the complete absence of terminal scalp hair (alopecia totalis) and those patients with total loss of terminal scalp and body hair (alopecia universalis) (Figures 2, 3).7 AA is common, the lifetime risk of AA in the gen- eral population is estimated to be 1.7%. The disease occurs in both genders and in all age groups, includ- ing children. AA presents before 16 years in approx- imately 20% of patients. In young infants, however, AA has been considered to be quite rare. Recent ar- ticles have suggested that this disorder may be more common in neonates and young infants than previ- ously supposed (Figure 4).8 Thus, AA can be clas- sifed as both an acquired and a congenital disorder. Earlier onset of AA may predispose the patient Figure 3.—When eyebrows and eyelashes are affected, the psy- to progression to more widespread disease. Walker chological involvement is enormous. and Rothman 9 reported that onset before puberty is correlated with severity, with 50% of his prepuber- except eyelashes, which are generally spared, usu- tal cases developing alopecia totalis compared with ally during the frst 3 months of life. Between the 23% who had an onset in the postpubertal period. Al- ages of 2 and 26 years, patients develop numerous though the trend toward disease severity in younger keratinous, papular cysts resembling milia on the patients is well established, it should be emphasized head, torso and extremities, distinguishing them that this cannot predict disease severity in an individ- from patients with alopecia totalis/alopecia uni- ual case and does not rule out future hair regrowth. versalis.8 The second rare condition to consider is Before the diagnosis of AA is made in infants with rickets resistant to 1.25-dihydroxyvitamin D. These patchy or initially patchy progressive hair loss, sev- patients present with loss of some or all scalp, body, eral other conditions must be considered. The cause and facial hair (with or without loss of eyelashes), of neonatal occipital alopecia may be synchronized typically within the frst 15 months of life. Affect- loss of telogen hairs on the occipital scalp at ap- ed children have clinical and radiological signs of proximately 8-12 weeks of age. Friction or pressure over the bony occipital prominence may contribute rickets, such as bowed limbs, extremity fractures, to this circumscribed hair loss.6 Alternatively, peri- and diffuse osteopenia, and laboratory abnormali- natal trauma associated with caput succedaneum ties. In the frst months of life, however, it may be can cause a pressure-induced alopecia, which often diffcult to distinguish vitamin D-resistant rickets presents as a “halo ring” of hair loss along the oc- from AA, because clinical signs of rickets may not cipital ridge.
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