SAFETY DATA SHEET Pentobarbital Sodium / Phenytoin Formulation Version Revision Date: SDS Number: Date of last issue: 2020/10/02 5.0 2021/04/09 671669-00015 Date of first issue: 2016/05/12 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Pentobarbital Sodium / Phenytoin Formulation Manufacturer or supplier's details Company : MSD Address : JL Raya Pandaan KM. 48 Pandaan, Jawa Timur - Indonesia Telephone : 908-740-4000 Emergency telephone number : 1-908-423-6000 E-mail address : [email protected] Recommended use of the chemical and restrictions on use Recommended use : Veterinary product 2. HAZARDS IDENTIFICATION GHS Classification Flammable liquids : Category 3 Acute toxicity (Oral) : Category 3 Skin sensitisation : Category 1 Carcinogenicity (Oral) : Category 2 Reproductive toxicity : Category 2 Specific target organ toxicity - : Category 1 (Central nervous system) single exposure Specific target organ toxicity - : Category 2 (Central nervous system) repeated exposure Long-term (chronic) aquatic : Category 3 hazard GHS label elements Hazard pictograms : Signal word : Danger Hazard statements : H226 Flammable liquid and vapour. H301 Toxic if swallowed. 1 / 18 SAFETY DATA SHEET Pentobarbital Sodium / Phenytoin Formulation Version Revision Date: SDS Number: Date of last issue: 2020/10/02 5.0 2021/04/09 671669-00015 Date of first issue: 2016/05/12 H317 May cause an allergic skin reaction. H351 Suspected of causing cancer if swallowed. H361 Suspected of damaging fertility or the unborn child. H370 Causes damage to organs (Central nervous system). H373 May cause damage to organs (Central nervous system) through prolonged or repeated exposure. H412 Harmful to aquatic life with long lasting effects. Precautionary statements : Prevention: P201 Obtain special instructions before use. P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No smoking. P233 Keep container tightly closed. P241 Use explosion-proof electrical/ ventilating/ lighting equip- ment. P242 Use only non-sparking tools. P243 Take precautionary measures against static discharge. P260 Do not breathe mist or vapours. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protec- tion/ face protection. Response: P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Rinse mouth. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediate- ly all contaminated clothing. Rinse skin with water/ shower. P308 + P311 IF exposed or concerned: Call a POISON CENTER/ doctor. P333 + P313 If skin irritation or rash occurs: Get medical ad- vice/ attention. P362 + P364 Take off contaminated clothing and wash it before reuse. Storage: P403 + P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. Disposal: P501 Dispose of contents/ container to an approved waste disposal plant. Other hazards which do not result in classification Vapours may form explosive mixture with air. 3. COMPOSITION/INFORMATION ON INGREDIENTS Substance / Mixture : Mixture 2 / 18 SAFETY DATA SHEET Pentobarbital Sodium / Phenytoin Formulation Version Revision Date: SDS Number: Date of last issue: 2020/10/02 5.0 2021/04/09 671669-00015 Date of first issue: 2016/05/12 Components Chemical name CAS-No. Concentration (% w/w) Pentobarbital sodium 57-33-0 >= 30 - < 60 Ethanol# 64-17-5 >= 10 - < 30 Phenytoin sodium 630-93-3 >= 3 - < 10 Benzyl alcohol 100-51-6 < 10 # Voluntarily-disclosed non-hazardous substance 4. FIRST AID MEASURES General advice : In the case of accident or if you feel unwell, seek medical ad- vice immediately. When symptoms persist or in all cases of doubt seek medical advice. If inhaled : If inhaled, remove to fresh air. Get medical attention. In case of skin contact : In case of contact, immediately flush skin with soap and plenty of water. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. In case of eye contact : Flush eyes with water as a precaution. Get medical attention if irritation develops and persists. If swallowed : If swallowed, DO NOT induce vomiting. Call a physician or poison control centre immediately. Rinse mouth thoroughly with water. Never give anything by mouth to an unconscious person. Most important symptoms : Toxic if swallowed. and effects, both acute and May cause an allergic skin reaction. delayed Suspected of causing cancer if swallowed. Suspected of damaging fertility or the unborn child. Causes damage to organs. May cause damage to organs through prolonged or repeated exposure. Protection of first-aiders : First Aid responders should pay attention to self-protection, and use the recommended personal protective equipment when the potential for exposure exists (see section 8). Notes to physician : Treat symptomatically and supportively. 5. FIREFIGHTING MEASURES Suitable extinguishing media : Water spray Alcohol-resistant foam Carbon dioxide (CO2) Dry chemical Unsuitable extinguishing : High volume water jet media Specific hazards during fire- : Do not use a solid water stream as it may scatter and spread fighting fire. Flash back possible over considerable distance. Vapours may form explosive mixtures with air. Exposure to combustion products may be a hazard to health. 3 / 18 SAFETY DATA SHEET Pentobarbital Sodium / Phenytoin Formulation Version Revision Date: SDS Number: Date of last issue: 2020/10/02 5.0 2021/04/09 671669-00015 Date of first issue: 2016/05/12 Hazardous combustion prod- : Carbon oxides ucts Nitrogen oxides (NOx) Metal oxides Specific extinguishing meth- : Use extinguishing measures that are appropriate to local cir- ods cumstances and the surrounding environment. Use water spray to cool unopened containers. Remove undamaged containers from fire area if it is safe to do so. Evacuate area. Special protective equipment : In the event of fire, wear self-contained breathing apparatus. for firefighters Use personal protective equipment. 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protec- : Remove all sources of ignition. tive equipment and emer- Use personal protective equipment. gency procedures Follow safe handling advice (see section 7) and personal pro- tective equipment recommendations (see section 8). Environmental precautions : Avoid release to the environment. Prevent further leakage or spillage if safe to do so. Prevent spreading over a wide area (e.g. by containment or oil barriers). Retain and dispose of contaminated wash water. Local authorities should be advised if significant spillages cannot be contained. Methods and materials for : Non-sparking tools should be used. containment and cleaning up Soak up with inert absorbent material. Suppress (knock down) gases/vapours/mists with a water spray jet. For large spills, provide dyking or other appropriate contain- ment to keep material from spreading. If dyked material can be pumped, store recovered material in appropriate container. Clean up remaining materials from spill with suitable absor- bent. Local or national regulations may apply to releases and dis- posal of this material, as well as those materials and items employed in the cleanup of releases. You will need to deter- mine which regulations are applicable. Sections 13 and 15 of this SDS provide information regarding certain local or national requirements. 7. HANDLING AND STORAGE Technical measures : See Engineering measures under EXPOSURE CONTROLS/PERSONAL PROTECTION section. Local/Total ventilation : If sufficient ventilation is unavailable, use with local exhaust ventilation. Use explosion-proof electrical, ventilating and lighting equip- ment. Advice on safe handling : Do not get on skin or clothing. 4 / 18 SAFETY DATA SHEET Pentobarbital Sodium / Phenytoin Formulation Version Revision Date: SDS Number: Date of last issue: 2020/10/02 5.0 2021/04/09 671669-00015 Date of first issue: 2016/05/12 Do not breathe mist or vapours. Do not swallow. Avoid contact with eyes. Wash skin thoroughly after handling. Handle in accordance with good industrial hygiene and safety practice, based on the results of the workplace exposure as- sessment Non-sparking tools should be used. Keep container tightly closed. Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Take precautionary measures against static discharges. Do not eat, drink or smoke when using this product. Take care to prevent spills, waste and minimize release to the environment. Conditions for safe storage : Keep in properly labelled containers. Store locked up. Keep tightly closed. Keep in a cool, well-ventilated place. Store in accordance with the particular national regulations. Keep away from heat and sources of ignition. Materials to avoid : Do not store with the following product types: Self-reactive substances and mixtures Organic peroxides Oxidizing agents Flammable gases Pyrophoric liquids Pyrophoric solids Self-heating substances and mixtures Poisonous gases Explosives 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Components with workplace control parameters Components CAS-No. Value type Control parame- Basis (Form of ters / Permissible exposure) concentration Pentobarbital sodium 57-33-0 TWA 40µg/m3 (OEB3) Internal Wipe limit 400µg/100cm2 Internal Ethanol 64-17-5 PSD 1,000 ppm ID OEL Further information: Confirmed animal