6th Pan-African Malaria Conference ABSTRACT BOOK MOVING TOWARDS MALARIA ELIMINATION: INVESTING IN RESEARCH AND CONTROL The International Convention Centre Durban, South Africa 6 -11 October 2013 PARTNERS SPONSORS Table of CONTENT 1. Minister of Health, South Africa ................................ 1 2. MIM Secretariat Chair ............................................... 2 3. MIM Scientific Co-chairs ........................................... 3 4. MIM Local Organising Committee ............................. 4 5. Committees ............................................................... 5 6. Plenary speakers - Biographies .......................................................... 7 - Schedule for Plenary speakers ............................ 15 - Plenary speakers abstracts .................................. 16 7. Symposia - Schedule .............................................................. 25 - Abstracts ............................................................. 28 8. Orals - Agenda ................................................................ 127 - Abstracts ............................................................. 141 9. Poster - Agenda ................................................................ 203 - Abstracts ............................................................. 238 6th MIM Conference 2013 6th MIM Conference MESSage FROM MINISTER OF HealTH It gives me great pleasure to welcome each one of you to the 6th MIM Pan-African Malaria Conference. Both Durban and the ICC have previously played host to an extremely successful MIM conference. In the 14 years that have passed since that conference, the face of malaria and malaria research have altered considerably on the African continent. Today malaria elimination rather than malaria control is spoken of as a real possibility in regions of the developing world once ravaged by malaria. South Africa is fortunate to be one of the countries where the burden of malaria has declined so significantly that elimination is now achievable. Regional collaboration in malaria control has been central to these successes, and underscores the importance of the coming together of the malaria community in our efforts to control and eventually eliminate the disease. MIM Meetings are the largest global gathering of malaria experts and present the ideal opportunity for pioneers and leaders in the field to meet, engage, exchange ideas and inspire each other as well as the future generation of malaria specialists. The conference also provides a platform for networking and the establishment of collaborations aimed at increasing the body of malaria knowledge and building capacity. During this conference you will have the privilege of hearing malaria experts from a variety of fields including vaccine development, drug development, parasite genomics, vector biology and malaria control deliver plenary lectures, scientific and symposium talks. I encourage you to use these occasions and the poster sessions to obtain as much information as possible to ensure a truly enriching conference experience. It is my hope that when you return to your countries and work-stations you use the knowledge gained at this conference to further malaria control and elimination efforts. In closing I would like to thank each of you for attending this conference and bringing your expertise and in-depth knowledge to the meeting. I encourage you to stay engaged and proactive throughout this conference to help ensure malaria elimination becomes a reality in our life time. Yours Sincerely, Dr Pakishe Aaron Motsoaledi Honourable Minister for Health South Africa 1 6th MIM Conference 2013 MESSage FROM MIM SECRETARIAT CHAIR Moving towards malaria elimination is a concept that demands careful execution. To achieve this undoubtedly would require investing in research and control and these two must walk hand in glove. The MIM conference is the largest gathering of the malaria community that provides one of the best opportunities to show case novel and ground breaking research, and foster interaction between research scientists and the control community. The second MIM Pan African Conference was held in Duban in 1999. We return to Durban thirteen years later to examine how the global face of malaria has changed considerably, with malaria elimination now a viable option in many African countries. The 6th MIM conference, returns to Durban to review successes, new problems and novel approaches. There has been some reduction in malaria burden. We have the artemisinins and now the possibility of the emergence of resistance, while the efficacy of IPTp with SP is being questioned. There is also the delineation of new dispersal routes of resistance of P. falciparum and anopheline vectors. We await the vaccine, and hope to hear more about its progress at this conference. Increasingly, we have detailed demographic surveillance that reports on habits and demographic changes. Close to 1500 young and eager minds will make it to the conference despite the economic downturn that affected sponsorship. Participants will be opportune to sample innovations from the Gates Foundation on the next new frontier in malaria programming, and on the Science of Eradication from the MalERA group, and the TDR with her new implementation research tool. A mix of control program managers will discuss new options from emerging data from academia and industry. Educational, networking and social events throughout the six days will bring participants to exchange ideas and addresses, make new contacts and forge new directions. This forum provides and fosters learning with unique opportunities for meeting with professionals in both the research and control communities The junior scientists/researchers will have the opportunity to meet with world class experts in the varied fields of malaria research and control. We hope that this will be another setting for new initiatives. While we debate, learn and teach others, we must not forget that there are dying women and children as we hold our conference. With the changing patterns of disease epidemiology, new vulnerable middle class groups are emerging; those with co-morbid infections suffer unduly. And the emergence of non-communicable diseases is another factor that will confound the clinical management of the disease. We need to stay practical and not loose hope, we need to focus on the actionable reasons why research on malaria and other infections need to be pursued. Probably, no knew drugs will come to the market soon enough and therefore we need to rely on what we have and what we know to innovate and improve on intervention uptake. Social Sciences alone will directly contribute seven out of ten of the actionable reasons by suggesting ways to break the vicious cycle between poverty and infectious diseases; forging an escape route for the poor and vulnerable; providing solution for tackling multiple problems at the same time; finding ways to mitigate life-long chronic illnesses and stigma; reaching out to the hardest to reach population through health systems improvements; preventing loss in translation; acting on what we know now. So let the band for the fight against malaria play on, with a better and improved tune, for a malaria free world. Enjoy the meeting Professor Rose Gana Fomban Leke Chair, MIM Secretariat 2 6th MIM Conference MESSage FROM SCIENTIFIC COMMITTEE co-ChAIrS It is a pleasure to welcome you to South Africa for the 6th Multilateral Initiative for Malaria Conference. Our theme “Moving towards malaria elimination: Investing in research and control” reflects the substantial advances that have been made in the past decade, reducing the burden of malaria globally and making elimination in tens of countries a realistic goal, albeit highly ambitious, expensive and slow. Achieving malaria elimination will clearly require major changes to current thinking – broadening our focus to include targetting of asymptomatic carriers of sub-microscopic parasite densities, and malaria surveillance must be greatly strengthened. However, this shift will result in failure if it happens at the cost of sustaining malaria control. There will always be a limit to the resources available for reducing the burden of malaria, so we need to learn how to work together more efficently and effectively. This is already happening, as reflected in there being more consortia and networks participating in this MIM conference than ever before. We will see how to make better use of limited resources, by sharing available data and tools, and using epidemiological and mathematical models to help focus further research and public health strategies. By facilitating prompt sharing and critical debate of new evidence with the malaria control programmes and ministries of health, solutions can start being implemented, and scientists can be made aware of the research gaps identified by those who deal with burden of malaria on a daily basis. International health agencies, and foundations will share their strategies and visions, and hear feedback from the malaria community, fostering partnerships. We will learn from reflecting on past successes (and failures), ensure the optimal use of available tools in the present, and look to the future for the new drugs, vaccines, diagnostics, integrated vector control strategies, and health systems strengthening that are all essential for tackling the many challenges posed by ongoing malaria transmission. In this way, the 6th MIM conference provides a powerful platform to achieve the synergy needed